Search

Your search keyword '"Coulon, Christine"' showing total 151 results
Start Over Author "Coulon, Christine"
151 results on '"Coulon, Christine"'

15. Synthesis of a [2- Pyridinyl- 18F]-labelled fluoro derivative of (−)-Cytisine as a candidate radioligand for brain nicotinic α4β2 receptor imaging with PET

Author

Roger, Gaëlle, Lagnel, Béatrice, Rouden, Jacques, Besret, Laurent, Valette, Héric, Demphel, Stéphane, Gopisetti, JaganMohan, Coulon, Christine, Ottaviani, Michele, Wrenn, Lori A, Letchworth, Sharon R, Bohme, Georg A, Benavides, Jesus, Lasne, Marie-Claire, Bottlaender, Michel, and Dollé, Frédéric

Published
2003
Full Text
View/download PDF

17. Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using [$^{18}$F]DPA-714

Author

Saba, Wadad, Goutal, Sébastien, Auvity, Sylvain, Kuhnast, Bertrand, Coulon, Christine, Kouyoumdjian, Virginie, Buvat, Irène, Leroy, Claire, Tournier, Nicolas, Imagerie Moléculaire in Vivo (IMIV - U1023 - ERL9218), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), ANR-11-INBS-0006,FLI,France Life Imaging(2011), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Tournier, Nicolas, and Infrastructures - France Life Imaging - - FLI2011 - ANR-11-INBS-0006 - INBS - VALID

Subjects
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Abstract

International audience; The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using Translocator Protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcoholnaive adolescent baboons (3-4 years old, 9 to 14 kg) underwent $^{18}$F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0.7-1.0 g/L). The brain distribution of $^{18}$F-DPA-714 (V$_T$; in mL.cm$^{-3}$) was estimated in several brain regions using the Logan Plot analysis and the metabolite-corrected arterial input function. Compared to alcohol-naive animals (V$_{T\ brain}$ = 3.7 ± 0.7 mL.cm$^{-3}$), The regional V$_T$s of $^{18}$F-DPA-714 were significantly increased during alcohol exposure (V$_{T\ brain}$ = 7.2 ± 0.4 mL.cm$^{-3}$ ; p

Published
2018
Full Text
View/download PDF

20. Nalmefene alleviates the neuroimmune response to repeated binge‐like ethanol exposure: A TSPO PET imaging study in adolescent rats.

Author

Tournier, Nicolas, Pottier, Géraldine, Caillé, Fabien, Coulon, Christine, Goislard, Maud, Jégo, Benoit, Negroni, Julia, Leroy, Claire, and Saba, Wadad

Subjects
POSITRON emission tomography, TRANSLOCATOR proteins, DIAGNOSTIC imaging, TEENAGE boys, BINGE drinking
Abstract

A large body of preclinical research has shown that neuroimmunity plays a key role in the deleterious effects of alcohol (ethanol) to the brain. Translational imaging techniques are needed to monitor the efficacy of strategies to prevent or mitigate neuroinflammation and alleviate ethanol‐induced neurotoxicity. Opioid receptor antagonists such as nalmefene are antagonists of the toll‐like receptor 4, which may block the proinflammatory signaling cascade induced by ethanol at this specific target. Male adolescent rats received a validated protocol of ethanol injection (i.p, 3 g/kg daily for two consecutive days followed by two resting days) during 14 days. Positron emission tomography (PET) imaging with the translocator protein 18 kDa (TSPO) radioligand [18F]DPA‐714 was performed at day‐15. Toxicity induced by repeated binge‐like ethanol exposure (71% mortality) was drastically reduced by nalmefene pretreatment (0.4 mg/kg, 14% mortality). No mortality was observed in animals that received vehicle (control) or nalmefene alone. Compared with control animals (n = 10), a significant 2.8‐fold to 4.6‐fold increase in the volume of distribution (VT) of [18F]DPA‐714 was observed among brain regions in animals exposed to ethanol only (n = 9). Pretreatment with nalmefene significantly alleviated the neuroimmune response to ethanol exposure in all brain regions (1.2‐fold to 2.5‐fold increase in VT; n = 5). Nalmefene alone (n = 6) did not impact [18F]DPA‐714 VT compared with the control group. Nalmefene may protect against the neuroinflammatory response and overall toxicity associated with binge drinking. [18F]DPA‐714 PET imaging can be used to noninvasively address the neuroimmune impact of ethanol exposure and its modulation by pharmacological strategies in vivo, with translational perspectives. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

25. Imaging the neuroimmune response to alcohol exposure in adolescent baboons: a TSPO PET study using 18 F-DPA-714.

Author

Saba, Wadad, Goutal, Sébastien, Auvity, Sylvain, Kuhnast, Bertrand, Coulon, Christine, Kouyoumdjian, Virginie, Buvat, Irène, Leroy, Claire, and Tournier, Nicolas

Subjects
BINGE drinking, BRAIN imaging, POSITRON emission tomography, NEUROGLIA, TRANSLOCATOR proteins, ANIMAL experimentation, BIOLOGICAL models, BRAIN, CELL receptors, COMPARATIVE studies, DEOXY sugars, ETHANOL, HETEROCYCLIC compounds, IMMUNITY, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, PRIMATES, RADIOPHARMACEUTICALS, RESEARCH, TIME, EVALUATION research
Abstract

The effects of acute alcohol exposure to the central nervous system are hypothesized to involve the innate immune system. The neuroimmune response to an initial and acute alcohol exposure was investigated using translocator protein 18 kDa (TSPO) PET imaging, a non-invasive marker of glial activation, in adolescent baboons. Three different alcohol-naive adolescent baboons (3-4 years old, 9 to 14 kg) underwent 18 F-DPA-714 PET experiments before, during and 7-12 months after this initial alcohol exposure (0.7-1.0 g/l). The brain distribution of 18 F-DPA-714 (VT ; in ml/cm3 ) was estimated in several brain regions using the Logan plot analysis and the metabolite-corrected arterial input function. Compared with alcohol-naive animals (VTbrain  = 3.7 ± 0.7 ml/cm3 ), the regional VT s of 18 F-DPA-714 were significantly increased during alcohol exposure (VTbrain  = 7.2 ± 0.4 ml/cm3 ; p < 0.001). Regional VT s estimated several months after alcohol exposure (VTbrain  = 5.7 ± 1.4 ml/cm3 ) were lower (p < 0.001) than those measured during alcohol exposure, but remained significantly higher (p < 0.001) than in alcohol-naive animals. The acute and long-term effects of ethanol exposure were observed globally across all brain regions. Acute alcohol exposure increased the binding of 18 F-DPA-714 to the brain in a non-human primate model of alcohol exposure that reflects the 'binge drinking' situation in adolescent individuals. The effect persisted for several months, suggesting a 'priming' of glial cell function after initial alcohol exposure. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

26. [18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106—Selective radioligands for imaging TSPO 18kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls

Author

Kuhnast, Bertrand, primary, Damont, Annelaure, additional, Hinnen, Françoise, additional, Catarina, Tony, additional, Demphel, Stéphane, additional, Le Helleix, Stéphane, additional, Coulon, Christine, additional, Goutal, Sébastien, additional, Gervais, Philippe, additional, and Dollé, Frédéric, additional

Published
2012
Full Text
View/download PDF

29. Quantification of Cerebral Nicotinic Acetylcholine Receptors by PET Using 2-[18F]Fluoro-A-85380 and the Multiinjection Approach

Author

Gallezot, Jean-Dominique, primary, Bottlaender, Michel A, additional, Delforge, Jacques, additional, Valette, Héric, additional, Saba, Wadad, additional, Dollé, Frédéric, additional, Coulon, Christine M, additional, Ottaviani, Michèle P, additional, Hinnen, Françoise, additional, Syrota, André, additional, and Grégoire, Marie-Claude, additional

Published
2007
Full Text
View/download PDF

30. Synthesis and radiolabeling of N-[4-[4-(2-[11C]methoxyphenyl)piperazin-1-yl]butyl]benzo[b]thiophene-2-carboxamide — a potential radiotracer for D3 receptor imaging with PET

Author

Kuhnast, Bertrand, primary, Valette, Héric, additional, Besret, Laurent, additional, Demphel, Stéphane, additional, Coulon, Christine, additional, Ottaviani, Michèle, additional, Guillermier, Martine, additional, Bottlaender, Michel, additional, and Dollé, Frédéric, additional

Published
2006
Full Text
View/download PDF

32. [11C]LBT-999: A suitable radioligand for investigation of extra-striatal dopamine transporter with PET

Author

Saba, Wadad, primary, Valette, Héric, additional, Schöllhorn-Peyronneau, Marie-Anne, additional, Coulon, Christine, additional, Ottaviani, Michele, additional, Chalon, Sylvie, additional, Dolle, Frédéric, additional, Emond, Patrick, additional, Halldin, Christer, additional, Helfenbein, Julie, additional, Madelmont, Jean-Claude, additional, Deloye, Jean-Bernard, additional, Guilloteau, Denis, additional, and Bottlaender, Michel, additional

Published
2006
Full Text
View/download PDF

33. Quantification in vivo of nicotinic acetylcholine receptors density and affinity in the baboon brain using 2-[18F]fluoro-A-85380 and a multi-injection approach

Author

Gallezot, Jean-Dominique, primary, Grégoire, Marie-Claude, additional, Bottlaender, Michel, additional, Frédéric, Dollé, additional, Wadad, Saba, additional, Coulon, Christine, additional, Ottaviani, Michèle, additional, Delforge, Jacques, additional, Syrota, André, additional, and Valette, Héric, additional

Published
2005
Full Text
View/download PDF

37. Synthesis, radiosynthesis and In vivo evaluation of 5-[3-(4-Benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[11C]one, as a potent NR1A/2B subtype selective NMDA PET radiotracer

Author

Roger, Gaëlle, primary, Lagnel, Béatrice, additional, Besret, Laurent, additional, Bramoullé, Yann, additional, Coulon, Christine, additional, Ottaviani, Michelle, additional, Kassiou, Michael, additional, Bottlaender, Michel, additional, Valette, Héric, additional, and Dollé, Frédéric, additional

Published
2003
Full Text
View/download PDF

38. Synthesis and in vivo imaging properties of [11C]befloxatone: A novel highly potent positron emission tomography ligand for mono-amine oxidase-A

Author

Dolle, Frédéric, primary, Valette, Héric, additional, Bramoulle, Yann, additional, Guenther, Ilonka, additional, Fuseau, Chantal, additional, Coulon, Christine, additional, Lartizien, Carole, additional, Jegham, Samir, additional, George, Pascal, additional, Curet, Olivier, additional, Pinquier, Jean-Louis, additional, and Bottlaender, Michel, additional

Published
2003
Full Text
View/download PDF

43. Highly efficient synthesis of [ 11 C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET

Author

Dolle, Frédéric, primary, Bottlaender, Michel, additional, Demphel, Stéphane, additional, Emond, Patrick, additional, Fuseau, Chantal, additional, Coulon, Christine, additional, Ottaviani, Michele, additional, Valette, Héric, additional, Loc'h, Christian, additional, Halldin, Christer, additional, Mauclaire, Laurent, additional, Guilloteau, Denis, additional, Maziere, Bernard, additional, and Crouzel, Christian, additional

Published
2000
Full Text
View/download PDF

44. Highly efficient synthesis of [11C]PE2I, a selective radioligand for the quantification of the dopamine transporter using PET

Author

Dolle, Fr�d�ric, primary, Bottlaender, Michel, additional, Demphel, St�phane, additional, Emond, Patrick, additional, Fuseau, Chantal, additional, Coulon, Christine, additional, Ottaviani, Michele, additional, Valette, H�ric, additional, Loc'h, Christian, additional, Halldin, Christer, additional, Mauclaire, Laurent, additional, Guilloteau, Denis, additional, Maziere, Bernard, additional, and Crouzel, Christian, additional

Published
2000
Full Text
View/download PDF

45. Synthesis and Nicotinic Acetylcholine Receptor in Vivo Binding Properties of 2-Fluoro-3-[2(S)-2-azetidinylmethoxy]pyridine: A New Positron Emission Tomography Ligand for Nicotinic Receptors

Author

Dollé, Frédéric, primary, Dolci, Lilian, additional, Valette, Héric, additional, Hinnen, Françoise, additional, Vaufrey, Françoise, additional, Guenther, Ilonka, additional, Fuseau, Chantal, additional, Coulon, Christine, additional, Bottlaender, Michel, additional, and Crouzel, Christian, additional

Published
1999
Full Text
View/download PDF

50. [11C]SL25.1188, a new reversible radioligand to study the monoamine oxidase type B with PET: Preclinical characterisation in nonhuman primate.

Author

Saba, Wadad, Valette, Héric, Peyronneau, Marie-Anne, Bramoullé, Yann, Coulon, Christine, Curet, Olivier, George, Pascal, Dollé, Frédéric, and Bottlaender, Michel

Abstract

[11C]SL-25.1188 [(S)-5-methoxymethyl-3-[6-(4,4,4-trifluorobutoxy)-benzo[ d]isoxazol-3-yl]-oxazolidin-2-one], an oxazolidinone derivative, was characterized in baboons as a radioligand for the in vivo visualization of MAO-B using positron emission tomography (PET). After i.v. injection, [11C]SL25.1188 presented a rapid phase of distribution in blood (about 5 min), followed by a T1/2 elimination of 85 ± 14 min. Plasma metabolism analysis showed that [11C]SL25.1188 is stable in vivo at least for 30 min. Brain uptake was rapid with the highest one observed in the striatum and thalamus, and the lowest in the pons. Calculated distribution volumes ( VT) were as follows: striatum = 10.3, thalamus = 10.9, hippocampus = 8.9, temporal cortex = 7.7, occipital cortex = 7.2, parietal cortex = 7.4, frontal cortex = 7.4, white matter = 7.4, and pons = 6.1. Pretreatment with deprenyl (2 mg/kg, i.v.) or lazabemide (0.5 mg/kg, i.v.) reduced VT values in all brain areas up to 50%. In displacement experiments, injection of SL25.1188 or deprenyl (1 and 2 mg/kg, i.v., respectively) strongly reduced the specific uptake of [11C]SL25.1188 in all brain areas (85-100%), while a lesser displacement was observed with lazabemide (0.5 mg/kg, i.v.) (55-70% of specific binding depending on the brain area). Therefore, [11C]SL25.1188 is characterized in vivo by reversible binding, high brain uptake and very slow plasma metabolism, strongly suggesting that this radioligand is a potent tool for the in vivo study of brain MAO-B. Synapse 64:61-69, 2010. © 2009 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results