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6 results on '"Coulibaly, Koudedja"'

3. Improvement of Peptidyl Copper Complexes Mimicking Catalase: A Subtle Balance between Thermodynamic Stability and Resistance towards H 2 O 2 Degradation.

Author

Ben Hadj Hammouda, Yaqine, Coulibaly, Koudedja, Bathily, Alimatou, Teoh Sook Han, Magdalene, Policar, Clotilde, and Delsuc, Nicolas

Subjects
*COPPER compounds, *CATALASE, *MOLECULAR weights, *METALLOPROTEINS, *ORGANIC conductors, *COPPER, *OXIDATIVE stress, *REACTIVE oxygen species
Abstract

Catalase mimics are low molecular weight metal complexes that reproduce the activity of catalase, an antioxidant metalloprotein that participates in the cellular regulation of H2O2 concentration by catalyzing its dismutation. H2O2 is a reactive oxygen species that is vital for the normal functioning of cells. However, its overproduction contributes to oxidative stress, which damages cells. Owing to their biocompatibility, peptidyl complexes are an attractive option for clinical applications to regulate H2O2 by enzyme mimics. We report here the synthesis and characterization of four new peptidyl di-copper complexes bearing two coordinating sequences. Characterization of the complexes showed that, depending on the linker used between the two coordinating sequences, their catalytic activity for H2O2 dismutation, their thermodynamic stability and their resistance to H2O2 degradation are very different, with (CATm2)Cu2 being the most promising catalyst. [ABSTRACT FROM AUTHOR]

Published
2022
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6. An easy-to-implement combinatorial approach involving an activity-based assay for the discovery of a peptidyl copper complex mimicking superoxide dismutase

Author

Vincent, Amandine, primary, Fores, Jennifer Rodon, additional, Tauziet, Elodie, additional, Quévrain, Elodie, additional, Dancs, Ágnes, additional, Conte-Daban, Amandine, additional, Bernard, Anne-Sophie, additional, Pelupessy, Philippe, additional, Coulibaly, Koudedja, additional, Seksik, Philippe, additional, Hureau, Christelle, additional, Selmeczi, Katalin, additional, Policar, Clotilde, additional, and Delsuc, Nicolas, additional

Published
2020
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