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1. Associations of circulating vitamins with 10-year retinal neurodegeneration: the Alienor Study

Author

Bénédicte MJ Merle, Cédric Schweitzer, Marie-Bénédicte Rougier, Audrey Cougnard-Grégoire, Laure Gayraud, Marie-Noëlle Delyfer, Jean-François Korobelnik, and Cécile Delcourt

Subjects
Vitamins, Nutrition, Neurodegeneration, Retina, Retinal nerve fiber layer (RNFL), Cohort, Internal medicine, RC31-1245
Abstract

Objective: To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness. Methods: The Alienor study, a prospective population-based cohort (Bordeaux, France), includes 963 individuals aged 73 years or older at baseline. The present study included 646 participants with complete RNFL measurement and vitamins. Study period is from 2009 to 2020. Peripapillary RNFL thickness was measured using spectral domain optical coherence tomography (SD-OCT). Plasma vitamins A, D and E and, serum vitamins B6, B9 and B12 were measured from blood sample. We performed linear mixed models, adjusted for age, gender, axial length, family history of glaucoma, and alcohol consumption to evaluated associations between vitamins and RNFL thickness changes over time. Results: Individuals having higher concentrations of vitamin E, D and B9 had a slower RNFL thinning during the 10-years of follow-up. Indeed, a 1-standard deviation (SD) increase of vitamin E (10.8 μmol/L), D (17.6 nmol/L) and B9 (11 μmol/L) were associated with slower RNFL thinning by 0.14 μm/year (95% confidence interval (CI), 0.03−0.25, p = 0.01), 0.14 μm/year (95% CI, 0.02−0.27, p = 0.02) and 0.11 μm/year (95% CI: 0.007−0.21, p = 0.04), respectively. No significant associations were observed for vitamins A, B6 and B12 with RNFL thinning. Conclusions: Higher levels of vitamins E, D and B9 were associated with a slower RNFL thickness on SD-OCT over time, suggesting that those vitamins may contribute to the neuroprotection of the retina.

Published
2024
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3. Association of Systemic Medication Use with Glaucoma and Intraocular Pressure: The European Eye Epidemiology Consortium

Author

Vergroesen, Joëlle E., Schuster, Alexander K., Stuart, Kelsey V., Asefa, Nigus G., Cougnard-Grégoire, Audrey, Delcourt, Cécile, Schweitzer, Cédric, Barreto, Patrícia, Coimbra, Rita, Foster, Paul J., Luben, Robert N., Pfeiffer, Norbert, Stingl, Julia V., Kirsten, Toralf, Rauscher, Franziska G., Wirkner, Kerstin, Jansonius, Nomdo M., Arnould, Louis, Creuzot-Garcher, Catherine P., Stricker, Bruno H., Keskini, Christina, Topouzis, Fotis, Bertelsen, Geir, Eggen, Anne E., Bikbov, Mukharram M., Jonas, Jost B., Klaver, Caroline C.W., Ramdas, Wishal D., and Khawaja, Anthony P.

Published
2023
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9. Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study

Author

Mauschitz, Matthias M., Schmitz, Marie-Therese, Verzijden, Timo, Schmid, Matthias, Thee, Eric F., Colijn, Johanna M., Delcourt, Cécile, Cougnard-Grégoire, Audrey, Merle, Bénédicte M.J., Korobelnik, Jean-François, Gopinath, Bamini, Mitchell, Paul, Elbaz, Hisham, Schuster, Alexander K., Wild, Philipp S., Brandl, Caroline, Stark, Klaus J., Heid, Iris M., Günther, Felix, Peters, Annette, Klaver, Caroline C.W., and Finger, Robert P.

Published
2022
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10. Development of a Genotype Assay for Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Ajana, Soufiane, Cougnard-Grégoire, Audrey, Delcourt, Cécile, Merle, Bénédicte M.J., Arango-Gonzalez, Blanca, Dammeier, Sascha, Diether, Sigrid, Honisch, Sabina, Kilger, Ellen, Ueffing, Marius, Endermann, Tanja, Zumbansen, Markus, Badura, Franz, De la Cerda, Berta, Biarnés, Marc, Borrell, Anna, Ferraro, Lucia L., Garcia, Míriam, Monés, Jordi, Rodríguez, Eduardo, Colijn, Johanna M., Ikram, A., Klaver, Caroline C.W., Meester-Smoor, Magda, Verzijden, Timo, Vingerling, Johannes, den Hollander, Anneke I., Heesterbeek, Thomas J., Kersten, Eveline, de Jong, Eiko K., Acar, I. Erkin, de Breuk, Anita, Emri, Eszter, Lengyel, Imre, Langen, Hanno, Nogoceke, Everson, Peto, Tunde, Luthert, Phil, Pool, Frances M., Acar, Ilhan E., Schijvenaars, Mascha M.V.A.P., Haer-Wigman, Lonneke, Bakker, Bjorn, de Jong, Sarah, Meester-Smoor, Magda A., Missotten, Tom O.A.R., Pauleikhoff, Daniel, Hense, Hans W., Silva, Rufino, Nunes, Sandrina, Melo, Joana B., Fauser, Sascha, Hoyng, Carel B., and Coenen, Marieke J.H.

Published
2021
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12. Predicting Progression to Advanced Age-Related Macular Degeneration from Clinical, Genetic, and Lifestyle Factors Using Machine Learning

Author

Acar, Erkin I., Arango-Gonzalez, Blanca, Armento, Angela, Badura, Franz, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Calado, Sofia M., Dammeier, Sascha, de Breuk, Anita, De la Cerda, Berta, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kilger, Ellen, Kortvely, Elod, Lastrucci, Claire, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodriguez-Bocanegra, Eduardo, Serrano, Luis, Sousa, Jose, Thee, Eric, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., Zumbansen, Markus, Ajana, Soufiane, Cougnard-Grégoire, Audrey, Colijn, Johanna M., Merle, Bénédicte M.J., Verzijden, Timo, de Jong, Paulus T.V.M., Hofman, Albert, Vingerling, Johannes R., Hejblum, Boris P., Korobelnik, Jean-François, Meester-Smoor, Magda A., Jacqmin-Gadda, Hélène, Klaver, Caroline C.W., and Delcourt, Cécile

Published
2021
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13. Associations of drusen location with risk factors and incidence of late age‐related macular degeneration in the Alienor study.

Author

Sénéclauze, Arnaud, Le Goff, Mélanie, Cougnard‐Grégoire, Audrey, Korobelnik, Jean‐François, Rougier, Marie‐Bénédicte, Delyfer, Marie‐Noëlle, Delcourt, Cécile, and Gattoussi, Sarra

Subjects
MACULAR degeneration, CATARACT surgery, BLOOD lipids, MEDICAL prescriptions
Abstract

Purpose: To test the hypothesis that central drusen location is strongly linked with known Age‐related Macular Degeneration (AMD) risk factors and risk of incident late AMD. Methods: The Alienor study is a prospective population‐based cohort study of residents of Bordeaux, France, followed from 2009 to 2017. On retinal photographs, we defined central drusen as at least one soft drusen (>63 μm) within 500 μm from fovea and pericentral drusen as at least one drusen 500–3000 μm from fovea, in the absence of any central drusen. Late AMD (atrophic and/or neovascular) was diagnosed using multimodal imaging. In total, 481 eyes were included in the analysis: 160 central and 321 pericentral. We investigated associations with systemic (age, sex, smoking, medical prescriptions, plasma concentrations of lipids and nutrients, UV exposure, blood pressure), ocular (retinal thickness, cataract extraction) and genetic risk scores (GRS). Results: In multivariate logistic regression central drusen were associated with smoking (OR, 2.95 for smoking more than 20 pack‐years, p = 0.02), HDL‐cholesterol (OR, 1.57 for 1 standard deviation (SD) increase, p = 0.0048), pulse pressure (OR, 0.77 for 1 SD increase, p = 0.04), Age‐Related Maculopathy Susceptibility 2 (ARMS2) GRS (OR, 1.42; 95% CI, 1.11–1.83) and complement GRS (OR, 1.55; 95% CI, 1.15–2.10). In Cox modelling, the central location of drusen (at baseline or during the follow‐up) was associated with a 4.41‐fold increased risk (95% CI,1.98–9.81) for an incident late AMD. Conclusion: Central drusen were strongly associated with AMD risk factors and incident late AMD, suggesting that it represents a key marker for AMD progression. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Integrating Metabolomics, Genomics, and Disease Pathways in Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Arango-Gonzalez, Blanca, Armento, Angela, Badura, Franz, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Calado, Sofia M., Dammeier, Sascha, Cerda, Berta De la, Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Honisch, Sabina, Kilger, Ellen, Kortvely, Elod, Lastrucci, Claire, Langen, Hanno, Lengyel, Imre, Luthert, Phil, Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodriguez-Bocanegra, Eduardo, Serrano, Luis, Sousa, Jose, Thee, Eric, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., Zumbansen, Markus, Acar, İlhan E., Lores-Motta, Laura, Colijn, Johanna M., Meester-Smoor, Magda A., Verzijden, Timo, Cougnard-Gregoire, Audrey, Ajana, Soufiane, Merle, Benedicte M.J., de Breuk, Anita, Heesterbeek, Thomas J., van den Akker, Erik, Daha, Mohamed R., Claes, Birte, Pauleikhoff, Daniel, Hense, Hans-Werner, van Duijn, Cornelia M., Fauser, Sascha, Hoyng, Carel B., Delcourt, Cécile, Klaver, Caroline C.W., Galesloot, Tessel E., and den Hollander, Anneke I.

Published
2020
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16. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future

Author

Ajana, Soufiane, Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Creuzot-Garcher, Catherine, Cumberland, Philippa, Cunha-Vaz, José, Daien, Vincent, Deak, Gabor, Delyfer, Marie-Noëlle, den Hollander, Anneke, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Nunes, Sandrina, Oexle, Konrad, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, Verhoeven, Virginie, Von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella, Buitendijk, Gabriëlle H.S., Alves, Dalila, Cachulo, Maria L., Khawaja, Anthony P., Cougnard-Gregoire, Audrey, Korb, Christina, Erke, Maja G., Anastasopoulos, Eleftherios, Meester-Smoor, Magda A., de Jong, Paulus T.V.M., Vingerling, Johannes R., Pfeiffer, Norbert, Fletcher, Astrid E., and Foster, Paul J.

Published
2017
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17. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration: Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Author

Acar, Niyazi, Altay, Lebriz, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Berendschot, Tos, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Bobak, Martin, Larsen, Morten Bøgelund, Boon, Camiel, Bourne, Rupert, Brétillon, Lionel, Broe, Rebecca, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carrière, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Cree, Angela, Creuzot-Garcher, Catherine, Cumberland, Phillippa, Cunha-Vaz, José, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Faria, Pedro, Farinha, Claudia, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Heesterbeek, Thomas, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, de Jong, Eiko, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Lehtimäki, Terho, Leung, Irene, Lotery, Andrew, Mauschitz, Matthias, Meester, Magda, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Rudnicka, Alicja, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schick, Tina, Schmitz-Valckenberg, Steffen, Schuster, Alexander, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Verzijden, Timo, Vingerling, Hans, Von Hanno, Therese, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Ajana, Soufiane, Arango-Gonzalez, Blanca, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle Inserm, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Zumbansen, Markus, Demirkan, Ayse, Meester-Smoor, Magda A., Merle, Benedicte M.J., Papageorgiou, Grigorios, Ahmad, Shahzad, Mulder, Monique T., Costa, Miguel Angelo, Benlian, Pascale, Bron, Alain M., Claes, Birte, Foster, Paul J., Hammond, Christopher J., Khawaja, Anthony P., Korobelnik, Jean-Francois, Souied, Eric H., Williams, Katie M., and van Duijn, Cornelia M.

Published
2019
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18. Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration: The EYE-RISK Consortium

Author

Ajana, Soufiane, Arango-Gonzalez, Blanca, Armento, Angela, Arndt, Verena, Bhatia, Vaibhav, Bhattacharya, Shomi S., Biarnés, Marc, Borrell, Anna, Bühren, Sebastian, Calado, Sofia M., Colijn, Johanna M., Cougnard-Grégoire, Audrey, Dammeier, Sascha, de Jong, Eiko K., De la Cerda, Berta, Delcourt, Cécile, den Hollander, Anneke I., Diaz-Corrales, Francisco J., Diether, Sigrid, Emri, Eszter, Endermann, Tanja, Ferraro, Lucia L., Garcia, Míriam, Heesterbeek, Thomas J., Honisch, Sabina, Hoyng, Carel B., Kersten, Eveline, Kilger, Ellen, Klaver, Caroline C.W., Langen, Hanno, Lengyel, Imre, Luthert, Phil, Maugeais, Cyrille, Meester-Smoor, Magda, Merle, Bénédicte M.J., Monés, Jordi, Nogoceke, Everson, Peto, Tunde, Pool, Frances M., Rodríguez, Eduardo, Ueffing, Marius, Ulrich Bartz-Schmidt, Karl U., van Leeuwen, Elisabeth M., Verzijden, Timo, Zumbansen, Markus, Vasiliev, Vassil, de Koning-Backus, Alexandra P.M., Delyfer, Marie-Noëlle, Kiefte-de Jong, Jessica C., Féart, Catherine, Samieri, Cécilia, Franco, Oscar H., and Korobelnik, Jean-François

Published
2019
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20. A new perspective on lipid research in age-related macular degeneration

Author

van Leeuwen, Elisabeth M., Emri, Eszter, Merle, Benedicte M.J., Colijn, Johanna M., Kersten, Eveline, Cougnard-Gregoire, Audrey, Dammeier, Sascha, Meester-Smoor, Magda, Pool, Frances M., de Jong, Eiko K., Delcourt, Cécile, Rodrigez-Bocanegra, Eduardo, Biarnés, Marc, Luthert, Philip J., Ueffing, Marius, Klaver, Caroline C.W., Nogoceke, Everson, den Hollander, Anneke I., and Lengyel, Imre

Published
2018
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21. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Author

Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Berendschot, Tos, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Bobak, Martin, Larsen, Morten Bøgelund, Boon, Camiel, Bourne, Rupert, Brétillon, Lionel, Broe, Rebecca, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carrière, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Cree, Angela, Creuzot-Garcher, Catherine, Cumberland, Phillippa, Cunha-Vaz, José, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Faria, Pedro, Farinha, Claudia, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Kersten, Eveline, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Lechanteur, Yara, Lehtimäki, Terho, Leung, Irene, Lotery, Andrew, Mauschitz, Matthias, Meester, Magda, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Rudnicka, Alicja, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schuster, Alexander, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Verzijden, Timo, Von Hanno, Therese, Wiedemann, Peter, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Mauschitz, Matthias M., Bonnemaijer, Pieter W.M., Diers, Kersten, Rauscher, Franziska G., Elze, Tobias, Engel, Christoph, Loeffler, Markus, Colijn, Johanna Maria, Ikram, M. Arfan, Vingerling, Johannes R., Williams, Katie M., Hammond, Christopher J., Bron, Alain M., Holz, Frank G., Klaver, Caroline C.W., Breteler, Monique M.B., and Finger, Robert P.

Published
2018
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22. The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans: A Meta-analysis of Published and Unpublished Data

Author

Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Berendschot, Tos, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Bobak, Martin, Boon, Camiel, Brétillon, Lionel, Broe, Rebecca, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Capuano, Vittorio, Carrière, Isabelle, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Johanna, Cougnard-Grégoire, Audrey, Cree, Angela, Creuzot-Garcher, Catherine, Cumberland, Phillippa, Cunha-Vaz, José, Daien, Vincent, De Jong, Eiko, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, den Hollander, Anneke, Dietzel, Martha, Erke, Maja Gran, Faria, Pedro, Farinha, Claudia, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Hansen, Morten, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Kersten, Eveline, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Lechanteur, Yara, Lehtimäki, Terho, Leung, Irene, Lotery, Andrew, Mauschitz, Matthias, Meester, Magda, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Mueller, Michael, Muldrew, Alyson, Murta, Joaquim, Nickels, Stefan, Nunes, Sandrina, Owen, Christopher, Peto, Tunde, Pfeiffer, Norbert, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Rauscher, Franziska, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Rudnicka, Alicja, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schouten, Johannes, Schuster, Alexander, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Speckauskas, Martynas, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, van Leeuwen, Elisa, Verhoeven, Virginie, Verzijden, Timo, Von Hanno, Therese, Vujosevic, Stela, Wiedemann, Peter, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, von Hanno, Therese, Khawaja, Anthony P., Verhoeven, Virginie J.M., Hogg, Ruth E., Höhn, René, Colijn, Johanna M., Buitendijk, Gabriëlle H.S., Evans, Jennifer, Nitsch, Dorothea, Yip, Jennifer L.Y., Foster, Paul J., and Klaver, Caroline C.W.

Published
2018
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27. Associations with intraocular pressure across Europe: The European Eye Epidemiology (E3) Consortium

Author

Khawaja, Anthony P., Springelkamp, Henriët, Creuzot-Garcher, Catherine, Delcourt, Cécile, Hofman, Albert, Höhn, René, Iglesias, Adriana I., Wolfs, Roger C. W., Korobelnik, Jean-François, Silva, Rufino, Topouzis, Fotis, Williams, Katie M., Bron, Alain M., Buitendijk, Gabriëlle H. S., Cachulo, Maria da Luz, Cougnard-Grégoire, Audrey, Dartigues, Jean-François, Hammond, Christopher J., Pfeiffer, Norbert, Salonikiou, Angeliki, van Duijn, Cornelia M., Vingerling, Johannes R., Luben, Robert N., Mirshahi, Alireza, Lamparter, Julia, Klaver, Caroline C. W., Jansonius, Nomdo M., Foster, Paul J., Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Annemarie, Cougnard-Grégoire, Audrey, Creuzot-Garcher, Catherine, Cumberland, Philippa, Cunha-Vaz, José, Daien, Vincent, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Muldrew, Alyson, Mueller, Michael, Nunes, Sandrina, Oexle, Konrad, Peto, Tunde, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, Verhoeven, Virginie, Von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella, and On behalf of the European Eye Epidemiology (E³) Consortium

Published
2016
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28. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration:A meta-analysis in Europeans

Author

Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, Giannoulis, Dimitrios A., Brandl, Caroline, Heid, Iris M., Creuzot-Garcher, Catherine P., Gabrielle, Pierre Henry, Hense, Hans Werner, Pauleikhoff, Daniel, Barreto, Patricia, Coimbra, Rita, Piermarocchi, Stefano, Daien, Vincent, Holz, Frank G., Delcourt, Cecile, Finger, Robert P., Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, Giannoulis, Dimitrios A., Brandl, Caroline, Heid, Iris M., Creuzot-Garcher, Catherine P., Gabrielle, Pierre Henry, Hense, Hans Werner, Pauleikhoff, Daniel, Barreto, Patricia, Coimbra, Rita, Piermarocchi, Stefano, Daien, Vincent, Holz, Frank G., Delcourt, Cecile, and Finger, Robert P.

Abstract

Background/aims: To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods: We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. Results: Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. Conclusion: Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.

Published
2023

29. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans.

Author

Mauschitz, Matthias M., Verzijden, Timo, Schuster, Alexander K., Elbaz, Hisham, Pfeiffer, Norbert, Khawaja, Anthony, Luben, Robert N., Foster, Paul J., Rauscher, Franziska G., Wirkner, Kerstin, Kirsten, Toralf, Jonas, Jost B., Bikbov, Mukharram M., Hogg, Ruth, Peto, Tunde, Cougnard-Grégoire, Audrey, Bertelsen, Geir, Erke, Maja Gran, Topouzis, Fotis, and Giannoulis, Dimitrios A.

Abstract

Background/aims To investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population. Methods We included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis. Results Between studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication. Conclusion Our study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD. [ABSTRACT FROM AUTHOR]

Published
2023
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32. Increasing Prevalence of Myopia in Europe and the Impact of Education

Author

Williams, Katie M., Bertelsen, Geir, Cumberland, Phillippa, Wolfram, Christian, Verhoeven, Virginie J.M., Anastasopoulos, Eleftherios, Buitendijk, Gabriëlle H.S., Cougnard-Grégoire, Audrey, Creuzot-Garcher, Catherine, Erke, Maja Gran, Hogg, Ruth, Höhn, René, Hysi, Pirro, Khawaja, Anthony P., Korobelnik, Jean-François, Ried, Janina, Vingerling, Johannes R., Bron, Alain, Dartigues, Jean-François, Fletcher, Astrid, Hofman, Albert, Kuijpers, Robert W.A.M., Luben, Robert N., Oxele, Konrad, Topouzis, Fotis, von Hanno, Therese, Mirshahi, Alireza, Foster, Paul J., van Duijn, Cornelia M., Pfeiffer, Norbert, Delcourt, Cécile, Klaver, Caroline C.W., Rahi, Jugnoo, and Hammond, Christopher J.

Published
2015
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34. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Author

Mauschitz, Matthias M, primary, Verzijden, Timo, additional, Schuster, Alexander K, additional, Elbaz, Hisham, additional, Pfeiffer, Norbert, additional, Khawaja, Anthony, additional, Luben, Robert N, additional, Foster, Paul J, additional, Rauscher, Franziska G, additional, Wirkner, Kerstin, additional, Kirsten, Toralf, additional, Jonas, Jost B, additional, Bikbov, Mukharram M, additional, Hogg, Ruth, additional, Peto, Tunde, additional, Cougnard-Grégoire, Audrey, additional, Bertelsen, Geir, additional, Erke, Maja Gran, additional, Topouzis, Fotis, additional, Giannoulis, Dimitrios A, additional, Brandl, Caroline, additional, Heid, Iris M, additional, Creuzot-Garcher, Catherine P, additional, Gabrielle, Pierre-Henry, additional, Hense, Hans-Werner, additional, Pauleikhoff, Daniel, additional, Barreto, Patricia, additional, Coimbra, Rita, additional, Piermarocchi, Stefano, additional, Daien, Vincent, additional, Holz, Frank G, additional, Delcourt, Cecile, additional, and Finger, Robert P, additional

Published
2022
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35. Prevalence of refractive error in Europe: the European Eye Epidemiology (E³) Consortium

Author

Williams, Katie M., Verhoeven, Virginie J. M., Cumberland, Phillippa, Bertelsen, Geir, Wolfram, Christian, Buitendijk, Gabriëlle H. S., Hofman, Albert, van Duijn, Cornelia M., Vingerling, Johannes R., Kuijpers, Robert W. A. M., Höhn, René, Mirshahi, Alireza, Khawaja, Anthony P., Luben, Robert N., Erke, Maja Gran, von Hanno, Therese, Mahroo, Omar, Hogg, Ruth, Gieger, Christian, Cougnard-Grégoire, Audrey, Anastasopoulos, Eleftherios, Bron, Alain, Dartigues, Jean-François, Korobelnik, Jean-François, Creuzot-Garcher, Catherine, Topouzis, Fotis, Delcourt, Cécile, Rahi, Jugnoo, Meitinger, Thomas, Fletcher, Astrid, Foster, Paul J., Pfeiffer, Norbert, Klaver, Caroline C. W., and Hammond, Christopher J.

Published
2015

36. Association of long-term exposure to ambient air pollution with retinal neurodegeneration on optical coherence tomography: the prospective Alienor study

Author

Laure Gayraud, Marion Mortamais, Cédric Schweitzer, Kees De Hoog, Audrey Cougnard-Grégoire, Jean-François Korobelnik, Marie-Noelle Delyfer, Marie-Bénédicte Rougier, Karen Leffondré, Catherine Helmer, Danielle Vienneau, Claudine Berr, and Cécile Delcourt

Subjects
General Earth and Planetary Sciences, General Environmental Science
Published
2022
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38. Association of long-term exposure to ambient air pollution with retinal neurodegeneration on optical coherence tomography: the prospective Alienor study

Author

Gayraud, Laure, primary, Mortamais, Marion, additional, Schweitzer, Cédric, additional, De Hoog, Kees, additional, Cougnard-Grégoire, Audrey, additional, Korobelnik, Jean-François, additional, Delyfer, Marie-Noelle, additional, Rougier, Marie-Bénédicte, additional, Leffondré, Karen, additional, Helmer, Catherine, additional, Vienneau, Danielle, additional, Berr, Claudine, additional, and Delcourt, Cécile, additional

Published
2022
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40. Association of lipid-lowering drugs and antidiabetic drugs with age-related macular degeneration: a meta-analysis in Europeans

Author

Matthias M Mauschitz, Timo Verzijden, Alexander K Schuster, Hisham Elbaz, Norbert Pfeiffer, Anthony Khawaja, Robert N Luben, Paul J Foster, Franziska G Rauscher, Kerstin Wirkner, Toralf Kirsten, Jost B Jonas, Mukharram M Bikbov, Ruth Hogg, Tunde Peto, Audrey Cougnard-Grégoire, Geir Bertelsen, Maja Gran Erke, Fotis Topouzis, Dimitrios A Giannoulis, Caroline Brandl, Iris M Heid, Catherine P Creuzot-Garcher, Pierre-Henry Gabrielle, Hans-Werner Hense, Daniel Pauleikhoff, Patricia Barreto, Rita Coimbra, Stefano Piermarocchi, Vincent Daien, Frank G Holz, Cecile Delcourt, Robert P Finger, Ophthalmology, and Epidemiology

Subjects
Cellular and Molecular Neuroscience, Ophthalmology, Sensory Systems
Abstract

Background/aimsTo investigate the association of commonly used systemic medications with prevalent age-related macular degeneration (AMD) in the general population.MethodsWe included 38 694 adults from 14 population-based and hospital-based studies from the European Eye Epidemiology consortium. We examined associations between the use of systemic medications and any prevalent AMD as well as any late AMD using multivariable logistic regression modelling per study and pooled results using random effects meta-analysis.ResultsBetween studies, mean age ranged from 61.5±7.1 to 82.6±3.8 years and prevalence ranged from 12.1% to 64.5% and from 0.5% to 35.5% for any and late AMD, respectively. In the meta-analysis of fully adjusted multivariable models, lipid-lowering drugs (LLD) and antidiabetic drugs were associated with lower prevalent any AMD (OR 0.85, 95% CI=0.79 to 0.91 and OR 0.78, 95% CI=0.66 to 0.91). We found no association with late AMD or with any other medication.ConclusionOur study indicates a potential beneficial effect of LLD and antidiabetic drug use on prevalence of AMD across multiple European cohorts. Our findings support the importance of metabolic processes in the multifactorial aetiology of AMD.

Published
2022
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41. Patterns of polyphenol intake and risk of depressive symptomatology in a population-based cohort of older adults

Author

Jeanne Bardinet, Camille Pouchieu, Hermine Pellay, Sophie Lefèvre-Arbogast, Virginie Chuy, Cédric Galéra, Catherine Helmer, David Gaudout, Cécilia Samieri, Cécile Delcourt, Audrey Cougnard-Grégoire, and Catherine Féart

Subjects
Cohort Studies, Young Adult, Nutrition and Dietetics, Phenols, Endocrinology, Diabetes and Metabolism, Humans, Polyphenols, Prospective Studies, Critical Care and Intensive Care Medicine, Antidepressive Agents, Antioxidants, Aged, Diet
Abstract

Current evidence suggests that some isolated polyphenols (PP) may exert promising effects for the risk of depression in young adults, however studies among older adults remain limited. The aim of the current study was to examine the prospective association between patterns of PP intake and the risk of depressive symptomatology (DS) in older adults.The study sample was based on the Three-City (3C) Bordeaux cohort of adults aged 65 years and over and without DS at the time of recruitment. The intakes of PP, summarised into 21 PP classes, were determined using a 24-h recall combined with the Phenol-Explorer database. In addition, the patterns of PP intake were identified by a Principal Component Analysis (PCA). DS was evaluated using the Center for Epidemiologic Studies Depression Scale (CES-D) over a period of 15 years with a reassessment every 2-3 years. The incident DS was reported for CES-D score ≥16 and/or the use of antidepressant treatment. The association between the patterns of PP intake at baseline and the risk of DS was computed using multivariate random-effect logistic regression models.Among the 1074 participants (mean age 75.7 y, SD 4.8 y), 423 (39.4%) developed a DS during the follow-up. Distinct patterns of PP intake were identified, explaining up to 50% of the variance. The two first patterns, mainly driven by stilbenes and dihydroflavonols and by hydroxyicnnamic acid and alkylmethoxyphenols respectively, were not associated with the odds of DS. Furthermore, a higher score on the third pattern, mainly driven by monomeric flavanols and theaflavins, was associated with a significant 27% lower risk of DS over time (Odd Ratio = 0.73, 95% Confidence Interval [0.55; 0.97]).This prospective study suggested that a pattern high in monomeric flavanols and theaflavins intakes, mainly provided by tea, was associated with a reduced risk of DS in older adults. These results provide promising evidence on combined PP intakes that would require further confirmation in other samples.

Published
2022

44. Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study.

Author

Mauschitz, M.M., Schmitz, M.T., Verzijden, T., Schmid, M., Thee, E.F., Colijn, J.M., Delcourt, C, Cougnard-Grégoire, A., Merle, B.M.J., Korobelnik, J.F., Gopinath, B., Mitchell, P., Elbaz, H., Schuster, A.K., Wild, P.S., Brandl, C., Stark, K.J., Heid, I.M., Günther, Felix, Peters, A., Klaver, C.C.W., Finger, R.P., Mauschitz, M.M., Schmitz, M.T., Verzijden, T., Schmid, M., Thee, E.F., Colijn, J.M., Delcourt, C, Cougnard-Grégoire, A., Merle, B.M.J., Korobelnik, J.F., Gopinath, B., Mitchell, P., Elbaz, H., Schuster, A.K., Wild, P.S., Brandl, C., Stark, K.J., Heid, I.M., Günther, Felix, Peters, A., Klaver, C.C.W., and Finger, R.P.

Abstract

01 april 2022, Item does not contain fulltext, PURPOSE: To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population. DESIGN: Meta-analysis of longitudinal cohort studies. METHODS: We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD. RESULTS: At baseline, mean age was 60.7 ± 6.9 to 76.4 ± 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD. CONCLUSIONS: Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact.

Published
2022

45. Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study.

Author

Audrey Cougnard-Grégoire, Bénédicte M J Merle, Jean-François Korobelnik, Marie-Bénédicte Rougier, Marie-Noëlle Delyfer, Mélanie Le Goff, Cécilia Samieri, Jean-François Dartigues, and Cécile Delcourt

Subjects
Medicine, Science
Abstract

Olive oil provides a mixture of lipids and antioxidant nutrients which may help preventing age-related diseases such as age-related macular degeneration (AMD). However, little is known about the associations between olive oil consumption and the risk of AMD.To examine associations between olive oil use and AMD prevalence in elderly subjects.Alienor (Antioxydants, Lipides Essentiels, Nutrition et maladies OculaiRes) is a population-based study on eye diseases performed in elderly residents of Bordeaux (France). In 1999-2000, frequencies of consumption of main categories of dietary fats used were collected. In 2006-2088, AMD was graded from non mydriatic retinal photographs into three exclusive stages: no AMD, early AMD, and late AMD. Two categories of preferred dietary fat used (olive oil, n-3 rich oils, n-6 rich oils, mixed oils, butter and margarine) were defined: "no use" and "regular use" (using fat for spreading and/or cooking and/or dressing). Associations of AMD with each fat use were estimated using Generalized Estimating Equation logistic regressions models.Our study included 654 subjects (1269 eyes) with complete data (n = 268 eyes with early AMD and n = 56 with late AMD). After adjustment for potential confounders, regular use of olive oil was significantly associated with a decreased risk of late AMD (odds ratio [OR] = 0.44, 95% confidence interval [CI]: 0.21;0.91). In contrast, regular use of olive oil was not significantly associated with early AMD (OR = 0.84, 95%CI: 0.59;1.21). No associations were found between regular consumption of n-3 rich oils, n-6 rich oils, mixed oils, butter and margarine and AMD, whatever the stage.This study suggests a protective effect of olive oil consumption for late AMD in this elderly community-dwelling population. Characterization of the mediating nutrients deserves further research.

Published
2016
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46. Development of a Genotype Assay for Age-Related Macular Degeneration

Author

de Breuk, Anita, primary, Acar, Ilhan E., additional, Kersten, Eveline, additional, Schijvenaars, Mascha M.V.A.P., additional, Colijn, Johanna M., additional, Haer-Wigman, Lonneke, additional, Bakker, Bjorn, additional, de Jong, Sarah, additional, Meester-Smoor, Magda A., additional, Verzijden, Timo, additional, Missotten, Tom O.A.R., additional, Monés, Jordi, additional, Biarnés, Marc, additional, Pauleikhoff, Daniel, additional, Hense, Hans W., additional, Silva, Rufino, additional, Nunes, Sandrina, additional, Melo, Joana B., additional, Fauser, Sascha, additional, Hoyng, Carel B., additional, Ueffing, Marius, additional, Coenen, Marieke J.H., additional, Klaver, Caroline C.W., additional, den Hollander, Anneke I., additional, Ajana, Soufiane, additional, Cougnard-Grégoire, Audrey, additional, Delcourt, Cécile, additional, Merle, Bénédicte M.J., additional, Arango-Gonzalez, Blanca, additional, Dammeier, Sascha, additional, Diether, Sigrid, additional, Honisch, Sabina, additional, Kilger, Ellen, additional, Endermann, Tanja, additional, Zumbansen, Markus, additional, Badura, Franz, additional, De la Cerda, Berta, additional, Borrell, Anna, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Rodríguez, Eduardo, additional, Ikram, A., additional, Meester-Smoor, Magda, additional, Vingerling, Johannes, additional, Heesterbeek, Thomas J., additional, de Jong, Eiko K., additional, Acar, I. Erkin, additional, de Breuk, Anita, additional, Emri, Eszter, additional, Lengyel, Imre, additional, Langen, Hanno, additional, Nogoceke, Everson, additional, Peto, Tunde, additional, Luthert, Phil, additional, and Pool, Frances M., additional

Published
2021
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47. Mediterranean Diet Adherence and Risk of Depressive Symptomatology in a French Population-Based Cohort of Older Adults

Author

Jeanne Bardinet, Virginie Chuy, Isabelle Carriere, Cédric Galéra, Camille Pouchieu, Cécilia Samieri, Catherine Helmer, Audrey Cougnard-Grégoire, and Catherine Féart

Subjects
Cohort Studies, Logistic Models, Nutrition and Dietetics, Mediterranean diet, depressive symptomatology, older adults, Three-City, cohort, Depression, Humans, Diet, Mediterranean, White People, Aged, Food Science
Abstract

Several foods from the Mediterranean Diet (MeDi) have already been characterized as beneficial for depression risk, while studies focusing on adherence to the overall MeDi are lacking among older adults at higher risk of depression. The aim of this study was to assess the association between MeDi adherence and the risk of depressive symptomatology (DS) in an older French cohort followed for 15 years. Participants from the Three-City Bordeaux cohort answered a food frequency questionnaire used to assess their MeDi adherence. The Center for Epidemiologic Studies Depression (CES-D) scale score of 16 or greater and/or use of antidepressant treatment ascertained at each visit defined incident DS. Random-effect logistic regression models were adjusted for potential confounders. Among 1018 participants, aged 75.6 years (SD 4.8 years) on average at baseline, 400 incident cases of DS were identified during the follow-up. Only when restricting the definition of DS to a CES-D score ≥ 16 was a borderline-significant trend towards a benefit of greater adherence to the MeDi with reduced odds of DS found (p-value = 0.053). In this large sample of older French adults, a potential benefit of greater adherence to the MeDi regarding the risk of DS would depend on the definition of DS.

Published
2022
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48. B Vitamins and Incidence of Advanced Age-Related Macular Degeneration: The Alienor Study

Author

Bénédicte M. J. Merle, Stéphanie Barthes, Catherine Féart, Audrey Cougnard-Grégoire, Jean-François Korobelnik, Marie-Bénédicte Rougier, Marie-Noëlle Delyfer, Cécile Delcourt, Admin, Oskar, PROGRAMME DE RECHERCHE EN SANTE PUBLIQUE - - VISA2010 - ANR-10-PRSP-0011 - PRSP - VALID, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Agence Nationale de la Recherche, Fondation Voir et Entendre, Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation, Caisse nationale de solidarité pour l'autonomie, and ANR-10-PRSP-0011,VISA(2010)

Subjects
Risk, Folate, Epidemiology, Population, age-related macular degeneration, vitamins B, folate, epidemiology, nutrition, cohort, risk, population, Cohort Studies, Macular Degeneration, Folic Acid, Risk Factors, Humans, Prospective Studies, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, Aged, Nutrition, Nutrition and Dietetics, Incidence, Age-related macular degeneration, Cohort, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Vitamins B, Vitamin B Complex, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Follow-Up Studies, Food Science
Abstract

B vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006–2008). Examinations were performed every two years over an eight-year period. The incidence of AMD is based on retinal fundus photographs and spectral-domain optical coherence tomography examinations. Among the 861 included participants, 93 developed incident AMD during a median follow-up time of 9.8 years. Participants with normal serum folate (≥10 nmol/L) significantly had a 51% reduced risk for AMD in the fully adjusted Cox model (HR, 0.49 [95% CI, 0.25–0.95], p = 0.036). Participants with a higher dietary intake of B5 and B6 vitamins had a lower risk for developing AMD of up to 28% (HR, 0.72 for 1-SD increase [0.53–0.99], p = 0.049; HR, 0.90 [0.81–0.99], p = 0.049, respectively). This cohort study of older adults suggests a strong association between a normal serum folate status, a high dietary intake of B5 and B6 and a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help to reduce vision loss due to AMD.

Published
2022
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49. Elevated high-density lipoprotein cholesterol and age-related macular degeneration: the Alienor study.

Author

Audrey Cougnard-Grégoire, Marie-Noëlle Delyfer, Jean-François Korobelnik, Marie-Bénédicte Rougier, Mélanie Le Goff, Jean-François Dartigues, Pascale Barberger-Gateau, and Cécile Delcourt

Subjects
Medicine, Science
Abstract

BACKGROUND: Lipid metabolism and particularly high-density lipoprotein (HDL) may be involved in the pathogenic mechanism of age-related macular degeneration (AMD). However, conflicting results have been reported in the associations of AMD with plasma HDL and other lipids, which may be confounded by the recently reported associations of AMD with HDL-related genes. We explored the association of AMD with plasma lipid levels and lipid-lowering medication use, taking into account most of HDL-related genes associated with AMD. METHODS: The Alienor study is a population-based study on age-related eye diseases performed in 963 elderly residents of Bordeaux (France). AMD was graded from non mydriatic color retinal photographs in three exclusive stages: no AMD (n = 430 subjects, 938 eyes); large soft distinct drusen and/or large soft indistinct drusen and/or reticular drusen and/or pigmentary abnormalities (early AMD, n = 176, 247); late AMD (n = 40, 61). Associations of AMD with plasma lipids (HDL, total cholesterol (TC), Low-density lipoprotein (LDL), and triglycerides (TG)) were estimated using Generalized Estimating Equation logistic regressions. Statistical analyses included 646 subjects with complete data. RESULTS: After multivariate adjustment for age, sex, educational level, smoking, BMI, lipid-lowering medication use, cardiovascular disease and diabetes, and for all relevant genetic polymorphisms (ApoE2, ApoE4, CFH Y402H, ARMS2 A69S, LIPC rs10468017, LIPC rs493258, LPL rs12678919, ABCA1 rs1883025 and CETP rs3764261), higher HDL was significantly associated with an increased risk of early (OR = 2.45, 95%CI: 1.54-3.90; P = 0.0002) and any AMD (OR = 2.29, 95%CI: 1.46-3.59; P = 0.0003). Association with late AMD was far from statistical significance (OR = 1.58, 95%CI: 0.48-5.17; p = 0.45). No associations were found for any stage of AMD with TC, LDL and TG levels, statin or fibrate drug use. CONCLUSIONS: This study suggests that elderly patients with high HDL concentration may be at increased risk for AMD and, further, that HDL dysfunction might be implicated in AMD pathogenesis.

Published
2014
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50. Genetic risk, lifestyle, and AMD in Europe. The EYE-RISK consortium

Author

Colijn, Johanna Maria, Meester, Magda, Verzijden, T., de Breuk, A., SILVA, R., Merle, Bénédicte M. J., Cougnard-Grégoire, Audrey, Hoyng, Carel B., Fauser, Sascha, Coolen, T., Creuzot-Garcher, Catherine, Hense, H.W., UEFFING, M., Delcourt, Cécile, den Hollander, Anneke I., Klaver, Caroline C. W., EYE-RISK consortium, ., Erasmus University Medical Center [Rotterdam] (Erasmus MC), Radboud University Medical Center [Nijmegen], Coimbra Institute for Clinical and Biomedical Research [Coimbra, Portugal] (iCBR - Faculty of Medicine), University of Coimbra [Portugal] (UC), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), University Hospital of Cologne [Cologne], King‘s College London, Service d'Ophtalmologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Muenster, University of Tübingen, European Commission (grant number 634479) + Erasmus Medical Center + Rotterdam Eye Hospital through the CORR (Combined Ophthalmic Research Rotterdam) Foundation + Uitzicht (grant number 2015-36)., and Julien, Sabine

Subjects
Europe, age-related macular degeneration (AMD), [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, pathways, population, genetics, [SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs, eye diseases
Abstract

International audience; PURPOSE: Age-related macular degeneration(AMD) is a common multifactorial disease in elderly with a prominent genetic basis. Many risk variants have been identified, but the interpretation is still challenging. We investigated the genetic distribution of AMD-associated risk variants in a large European consortium, calculated attributable, and pathway-specific genetic risks, and assessed the influence of lifestyle on genetic outcomes. DESIGN: Pooled analysis of cross-sectional data from the E3 consortium. PARTICIPANTS: 17.174 individuals aged 45+ participating in 6 population-based cohort studies, 2 clinic based studies, 1 case-control study. METHODS: AMD was diagnosed and graded based on fundus photographs. Data on genetics, lifestyle, and diet were harmonized and completed where necessary. Minor allele frequencies and population attributable fraction (PAF) were calculated per single nucleotide polymorphism (SNP). A total genetic risk score (GRS) and pathway-specific risk scores (complement, lipid, extra-cellular matrix, other) were constructed based on the dosage of SNPs and conditional beta's; a lifestyle score was constructed based on smoking and dietary intake. RESULTS: The risk variants with the largest difference between late AMD cases and controls, and the highest PAFs were located in ARMS2 (rs3750846) and CHF (rs570618 and rs10922109). Both risk increasing and protective variants had the highest PAFs. Combining all genetic variants, the total genetic risk score ranged from -3.50 to 4.63, was normally distributed and increased with AMD severity. Of the late AMD cases, 1581/1777 (89%) had a positive total GRS. The complement pathway and ARMS2 were by far the most prominent genetic pathways contributing to late AMD (positive GRS 90% of late cases), but risk in three pathways was most frequent (35% of late cases). Lifestyle was a strong determinant of the outcome in each genetic risk category; unfavorable lifestyle increased the risk of late AMD at least twofold. CONCLUSIONS: Genetic risk variants contribute to late AMD in the majority of cases. However, lifestyle factors have a strong influence on the outcome of genetic risk, and should be a strong focus in patient management. Genetic risks in ARMS2 and the complement pathway are present in the majority of late AMD, but are mostly combined with risks in other pathways.

Published
2021
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