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5. Acceptance, efficacy, and safety of COVID-19 vaccination in older patients with cancer

Author

Couderc, Anne-Laure, Ninove, Laetitia, Nouguerède, Emilie, Rey, Dominique, Rebroin, Marina, Daumas, Aurélie, Tomasini, Pascale, Greillier, Laurent, Salas, Sebastien, Duffaud, Florence, Dahan, Laetitia, Duluc, Muriel, Garcia, Marie-Eve, Pluvy, Johan, Chaléat, Solène, Farnault, Laure, Venton, Geoffroy, Fourié, Toscane, Nurtop, Elif, de Lamballerie, Xavier, Villani, Patrick, Charrel, Remi, and Correard, Florian

Published
2022
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7. Functional status in older patients with cancer

Author

Couderc, Anne-Laure, Suchon, Pierre, Saliba-Serre, Bérengère, Rey, Dominique, Nouguerede, Emilie, Arcani, Robin, Farnault, Laure, Daumas, Aurélie, Courcier, Anais, Duffaud, Florence, Salas, Sébastien, Barlesi, Fabrice, Greillier, Laurent, Costello, Régis, Venton, Geoffroy, and Villani, Patrick

Published
2022
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21. Tagravpa: Help table and grid for identifying the risk of aggravation and early rehospitalization of elderly persons 75 years and older referred to emergency departments and/or hospitalized in care units

Author

Bourriquen, Maryline, additional, Delalande, Géraldine, additional, Couderc, Anne-Laure, additional, Persico, Nicolas, additional, Berbis, Julie, additional, Paganelli, Franck, additional, Boyer, Laurent, additional, Roch, Antoine, additional, Daumas, Aurélie, additional, Lalys, Loïc, additional, and Villani, Patrick, additional

Published
2023
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22. Tocilizumab versus anakinra in COVID-19: results from propensity score matching

Author

Arcani, Robin, primary, Correard, Florian, additional, Suchon, Pierre, additional, Kaplanski, Gilles, additional, Jean, Rodolphe, additional, Cauchois, Raphael, additional, Leprince, Marine, additional, Arcani, Vincent, additional, Seguier, Julie, additional, De Sainte Marie, Benjamin, additional, Andre, Baptiste, additional, Koubi, Marie, additional, Rossi, Pascal, additional, Gayet, Stéphane, additional, Gobin, Nirvina, additional, Garrido, Victoria, additional, Weiland, Joris, additional, Jouve, Elisabeth, additional, Couderc, Anne-Laure, additional, Villani, Patrick, additional, and Daumas, Aurélie, additional

Published
2023
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23. Therapy-related myeloid neoplasms after 177Lu-DOTATATE therapy for metastatic neuroendocrine neoplasia: CPX-351 consolidated by allogeneic stem cells transplantation as applicable therapeutic strategy

Author

Berton, Guillaume, primary, Arcani, Robin, additional, Tichadou, Antoine, additional, Farnault, Laure, additional, Roche, Pauline, additional, Colle, Julien, additional, Ivanov, Vadim, additional, Mercier, Cédric, additional, Couderc, Anne-Laure, additional, Costello, Regis, additional, Taïeb, David, additional, and Venton, Geoffroy, additional

Published
2023
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24. PREDOMOS study, impact of a social intervention program for socially isolated elderly cancer patients: update to the study protocol for a randomized controlled trial

Author

Couderc, Anne-Laure, Nouguerède, Emilie, Baumstarck, Karine, Loubière, Sandrine, Le Caer, Hervé, Guillem, Olivier, Rousseau, Frédérique, Greillier, Laurent, Norguet-Monnereau, Emmanuelle, Cecile, Maud, Boulahssass, Rabia, Le Caer, Françoise, Tournier, Sandrine, Butaud, Chantal, Guillet, Pierre, Nahon, Sophie, Kirscher, Sylvie, Diaz, Nadine, Morando, Claire, Villani, Patrick, Auquier, Pascal, and Daumas, Aurélie

Published
2019
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25. Pre-Therapeutic Sarcopenia among Cancer Patients: An Up-to-Date Meta-Analysis of Prevalence and Predictive Value during Cancer Treatment

Author

Couderc, Anne-Laure, primary, Liuu, Evelyne, additional, Boudou-Rouquette, Pascaline, additional, Poisson, Johanne, additional, Frelaut, Maxime, additional, Montégut, Coline, additional, Mebarki, Soraya, additional, Geiss, Romain, additional, ap Thomas, Zoé, additional, Noret, Aurélien, additional, Pierro, Monica, additional, Baldini, Capucine, additional, Paillaud, Elena, additional, and Pamoukdjian, Frédéric, additional

Published
2023
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26. Impact of Molecular Biology in Diagnosis, Prognosis, and Therapeutic Management of BCR::ABL1-Negative Myeloproliferative Neoplasm

Author

Abbou, Norman, primary, Piazzola, Pauline, additional, Gabert, Jean, additional, Ernest, Vincent, additional, Arcani, Robin, additional, Couderc, Anne-Laure, additional, Tichadou, Antoine, additional, Roche, Pauline, additional, Farnault, Laure, additional, Colle, Julien, additional, Ouafik, L’houcine, additional, Morange, Pierre, additional, Costello, Régis, additional, and Venton, Geoffroy, additional

Published
2022
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29. Tagravpa : Tableau d'aide et grille de repérage du risque d'aggravation et de réhospitalisation précoce des personnes âgées de 75 ans et plus adressées aux urgences et/ou hospitalisées dans les unités de soins

Author

Bourriquen, Maryline, Delalande, Géraldine, Couderc, Anne-Laure, Persico, Nicolas, Berbis, Julie, Paganelli, Franck, Boyer, Laurent, Roch, Antoine, Daumas, Aurélie, Lalys, Loïc, and Villani, Patrick

Subjects
FRAIL elderly, OLDER people, DISEASE risk factors, HOSPITAL emergency services, ELDER care, UNIVERSITY hospitals
Abstract

Copyright of Gériatrie et Psychologie Neuropsychiatrie du Vieillissement is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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30. Impact of Molecular Biology in Diagnosis, Prognosis, and Therapeutic Management of BCR::ABL1 -Negative Myeloproliferative Neoplasm.

Author

Abbou, Norman, Piazzola, Pauline, Gabert, Jean, Ernest, Vincent, Arcani, Robin, Couderc, Anne-Laure, Tichadou, Antoine, Roche, Pauline, Farnault, Laure, Colle, Julien, Ouafik, L'houcine, Morange, Pierre, Costello, Régis, and Venton, Geoffroy

Subjects
MOLECULAR biology, MYELOPROLIFERATIVE neoplasms, MOLECULAR diagnosis, POLYCYTHEMIA vera, RNA splicing
Abstract

BCR::ABL1-negative myeloproliferative neoplasms (MPNs) include three major subgroups—polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF)—which are characterized by aberrant hematopoietic proliferation with an increased risk of leukemic transformation. Besides the driver mutations, which are JAK2, CALR, and MPL, more than twenty additional mutations have been identified through the use of next-generation sequencing (NGS), which can be involved with pathways that regulate epigenetic modifications, RNA splicing, or DNA repair. The aim of this short review is to highlight the impact of molecular biology on the diagnosis, prognosis, and therapeutic management of patients with PV, ET, and PMF. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Targeted Therapy for Older Patients with Non-Small Cell Lung Cancer: Systematic Review and Guidelines from the French Society of Geriatric Oncology (SoFOG) and the French-Language Society of Pulmonology (SPLF)/French-Language Oncology Group (GOLF)

Author

Greillier, Laurent, primary, Gauvrit, Manon, additional, Paillaud, Elena, additional, Girard, Nicolas, additional, Montégut, Coline, additional, Boulahssass, Rabia, additional, Wislez, Marie, additional, Pamoukdjian, Frédéric, additional, Corre, Romain, additional, Cabart, Mathilde, additional, Caillet, Philippe, additional, Belaroussi, Yaniss, additional, Frasca, Matthieu, additional, Noize, Pernelle, additional, Wang, Pascal, additional, Mebarki, Soraya, additional, Mathoulin-Pelissier, Simone, additional, and Couderc, Anne-Laure, additional

Published
2022
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32. PREDOMOS study, impact of a social intervention program for socially isolated elderly cancer patients: study protocol for a randomized controlled trial

Author

Crétel-Durand, Elodie, Nouguerède, Emilie, Le Caer, Hervé, Rousseau, Frédérique, Retornaz, Frédérique, Guillem, Olivier, Couderc, Anne-Laure, Greillier, Laurent, Norguet, Emmanuelle, Cécile, Maud, Boulahssass, Rabia, Le Caer, Francoise, Tournier, Sandrine, Butaud, Chantal, Guillet, Pierre, Nahon, Sophie, Poudens, Laure, Kirscher, Sylvie, Loubière, Sandrine, Diaz, Nadine, Dhorne, Jean, Auquier, Pascal, and Baumstarck, Karine

Published
2017
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33. Prognostic Value of the B12/CRP Index in Older Systemically Treatable Cancer Patients

Author

Montegut, Coline, primary, Correard, Florian, additional, Nouguerède, Emilie, additional, Rey, Dominique, additional, Chevalier, Thomas, additional, Meurer, Marie, additional, Deville, Jean-Laurent, additional, Baciuchka, Marjorie, additional, Pradel, Vincent, additional, Greillier, Laurent, additional, Villani, Patrick, additional, and Couderc, Anne-Laure, additional

Published
2021
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34. Prevalence and prognostic impact of cachexia among older patients with cancer: a nationwide cross‐sectional survey (NutriAgeCancer)

Author

Poisson, Johanne, primary, Martinez‐Tapia, Claudia, additional, Heitz, Damien, additional, Geiss, Romain, additional, Albrand, Gilles, additional, Falandry, Claire, additional, Gisselbrecht, Mathilde, additional, Couderc, Anne‐Laure, additional, Boulahssass, Rabia, additional, Liuu, Evelyne, additional, Boudou‐Rouquette, Pascaline, additional, Chah Wakilian, Anne, additional, Gaxatte, Cedric, additional, Pamoukdjian, Fréderic, additional, de Decker, Laure, additional, Antoine, Valery, additional, Cattenoz, Catherine, additional, Solem‐Laviec, Heidi, additional, Guillem, Olivier, additional, Medjenah, Hayat, additional, Natella, Pierre André, additional, Canouï‐Poitrine, Florence, additional, Laurent, Marie, additional, and Paillaud, Elena, additional

Published
2021
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35. Centenarians in nursing homes during the COVID-19 pandemic

Author

Couderc, Anne-Laure, Correard, Florian, Nouguerède, Emilie, Berbis, Julie, Rey, Dominique, Daumas, Aurélie, Villani, Patrick, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), and Assistance Publique - Hôpitaux de Marseille (APHM)

Subjects
Aged, 80 and over, Male, Depression, SARS-CoV-2, [SDV]Life Sciences [q-bio], Age Factors, COVID-19, Comorbidity, Prognosis, mortality, Nursing Homes, [SHS]Humanities and Social Sciences, nursing home, symptoms, Humans, Female, centenarians, France, Pandemics, ComputingMilieux_MISCELLANEOUS, Research Paper, Aged, Retrospective Studies
Abstract

Background: Centenarians are known to be successful agers compared to other older adults.Objective: The objective of the present study was to compare coronavirus disease (COVID-19) symptoms and outcomes in centenarians and other residents living in nursing homes. Design-Setting-Subjects-Methods: A retrospective multicenter cohort study was conducted using data from 15 nursing homes in the Marseille area. Older residents with confirmed COVID-19 between March and June 2020 were enrolled. The clinical and biological characteristics, the treatment measures, and the outcomes in residents living in these nursing homes were collected from the medical records. Results: A total of 321 residents were diagnosed with COVID-19 including 12 centenarians. The median age was 101 years in centenarians and 89 years in other residents. The most common symptoms were asthenia and fever. Three centenarians (25%) experienced a worsening of pre-existing depression (vs. 5.5% of younger residents; p = 0.032). Mortality was significantly higher in centenarians than in younger residents (50% vs. 21.3%, respectively; p = 0.031). A quarter of the younger residents and only one centenarian were hospitalized. However, 33.3% of the centenarians received treatment within the context of home hospitalization. Conclusion: Worsening of pre-existing depression seems to be more frequent in centenarians with COVID-19 in nursing homes. This population had a higher mortality rate but a lower hospitalization rate than younger residents.

Published
2021

36. Stereotactic Body Radiotherapy for Frail Patients with Primary Renal Cell Carcinoma: Preliminary Results after 4 Years of Experience

Author

Grelier, Laure, primary, Baboudjian, Michael, additional, Gondran-Tellier, Bastien, additional, Couderc, Anne-Laure, additional, McManus, Robin, additional, Deville, Jean-Laurent, additional, Carballeira, Ana, additional, Delonca, Raphaelle, additional, Delaporte, Veronique, additional, Padovani, Laetitia, additional, Boissier, Romain, additional, Lechevallier, Eric, additional, and Muracciole, Xavier, additional

Published
2021
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37. Severe and Irreversible Pancytopenia Associated With SARS-CoV-2 Bone Marrow Infection in a Patient With Waldenstrom Macroglobulinemia

Author

Velier, Mélanie, primary, Priet, Stéphane, additional, Appay, Romain, additional, Atieh, Thérèse, additional, Lepidi, Hubert, additional, Kaplanski, Gilles, additional, Jarrot, Pierre André, additional, Koubi, Marie, additional, Costello, Régis, additional, Dignat-George, Françoise, additional, de Lamballerie, Xavier, additional, Tichadou, Antoine, additional, Arcani, Robin, additional, Couderc, Anne Laure, additional, Touati, Julian, additional, Varoquaux, Arthur, additional, Berda-Haddad, Yaël, additional, and Venton, Geoffroy, additional

Published
2021
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39. Medication Reconciliation Associated with Comprehensive Geriatric Assessment in Older Patients with Cancer: ChimioAge Study

Author

Couderc, Anne-Laure, Boisseranc, Celia, Rey, Dominique, Nouguerede, Emilie, Greillier, Laurent, Barlesi, Fabrice, Duffaud, Florence, Deville, Laurent, Honoré, Stéphane, Villani, Patrick, Correard, Florian, Assistance Publique - Hôpitaux de Marseille (APHM), Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU), Service d’Oncologie Médicale [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre régional de pharmacovigilance de Marseille Provence Corse [CHU de Marseille] (CRPV-Marseille), Assistance Publique - Hôpitaux de Marseille (APHM)-CHU Marseille, and CHU Marseille-Assistance Publique-Hôpitaux de Marseille (AP-HM)

Subjects
Aged, 80 and over, Male, geriatric assessment, [SDV]Life Sciences [q-bio], [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Clinical Decision-Making, antineoplastic protocols, [SDV.CAN]Life Sciences [q-bio]/Cancer, Medical Oncology, Patient Care Planning, [SHS]Humanities and Social Sciences, [SDV.ETH]Life Sciences [q-bio]/Ethics, aged, Neoplasms, Clinical Interventions in Aging, Polypharmacy, medication reconciliation, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Humans, Female, Prospective Studies, ComputingMilieux_MISCELLANEOUS, Original Research, treatment failure
Abstract

Anne-Laure Couderc,1,2 Celia Boisseranc,3 Dominique Rey,1 Emilie Nouguerede,1 Laurent Greillier,4,5 Fabrice Barlesi,4,5 Florence Duffaud,4,6 Jean-Laurent Deville,6 Stéphane Honoré,3,4 Patrick Villani,1,2 Florian Correard3,4 1Internal Medicine, Geriatry and Therapeutic Unit, AP-HM, Marseille, France;Coordination Unit for Geriatric Oncology (UCOG), PACA West, Marseille, France; 2Aix-Marseille Université, CNRS, EFS, ADES, Marseille, France; 3Pharmacology Department, AP-HM, Marseille, France; 4Aix-Marseille University, Marseille, France; 5Multidisciplinary Oncology and Therapeutic Innovations Unit, AP-HM, Marseille, France; 6Oncology Unit, AP-HM, Marseille, FranceCorrespondence: Anne-Laure CoudercCoordination Unit for Geriatric Oncology (UCOG), PACA West, University Hospital of Marseille (AP-HM), 270 Boulevard De Sainte Marguerite, Marseille 13009, FranceTel +33 491744530Fax +33 491744833Email anne-laure.couderc@ap-hm.frBackground: Polymorbidity induces polypharmacy in older patients may lead to potential drug–drug interactions (DDI) which can modify the tolerance and safety of oncological treatments and alter the intended therapeutic effect. The objective of our study was to describe the decision-making process for oncological treatment and related outcomes, in a population of older adults undergoing a comprehensive geriatric assessment (CGA) associated to a comprehensive medication reconciliation (CMR) prior to initiating oncological treatment.Methods: ChimioAge is a prospective observational study conducted between 01/2017 and 07/2018 at Marseille University Hospital and approved by the French National Ethics Committee. It comprised all consecutive patients aged 70 years and over who were referred for a CGA as part of CMR, before initiating systemic treatment.Results: One hundred and seventy-one cancer patients were included. Mean age was 79.2 years, over half had metastatic cancers, 75% had an ECOG performance status zero or one, and two-thirds were independent in daily activities. Two-thirds of the patients had polypharmacy and the CMR identified potential DDI with systemic treatment in 43.3% of patients. Following the CGA, the CMR and the hospital oncologists decision, 30% of the patients received adapted systemic treatment with reduced doses at initiation. They presented fewer toxicities – irrespective of grade and type – than patients who received standard treatment (p< 0.001) and had comparable overall survival (Log rank p=0.21).Conclusion: This is one of the first studies to highlight the value in conducting CMR and a CGA simultaneously before initiating systemic treatment in older patients with cancer. These two evaluations could give oncologists decisive information to personalize cancer treatment of older patients and optimize treatment dose to offer the best efficacy and minimize toxicity.Keywords: aged, antineoplastic protocols, geriatric assessment, medication reconciliation, treatment failure

Published
2020

40. Impact of Androgen Deprivation Therapy Associated to Conformal Radiotherapy in the Treatment of D’Amico Intermediate-/High-Risk Prostate Cancer in Older Patients

Author

Couderc, Anne-Laure, primary, Nicolas, Emanuel, additional, Boissier, Romain, additional, Boucekine, Mohammed, additional, Bastide, Cyrille, additional, Badinand, Delphine, additional, Rossi, Dominique, additional, Mugnier, Benedicte, additional, Villani, Patrick, additional, Karsenty, Gilles, additional, Cowen, Didier, additional, Lechevallier, Eric, additional, and Muracciole, Xavier, additional

Published
2020
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41. High Serum Vitamin B12 Levels Associated with C-Reactive Protein in Older Patients with Cancer

Author

Couderc, Anne-Laure, primary, Puchades, Eddy, additional, Villani, Patrick, additional, Arcani, Robin, additional, Farnault, Laure, additional, Daumas, Aurélie, additional, Courcier, Anais, additional, Greillier, Laurent, additional, Barlesi, Fabrice, additional, Duffaud, Florence, additional, Salas, Sébastien, additional, Costello, Régis, additional, Gentile, Gaëtan, additional, Pradel, Vincent, additional, Suchon, Pierre, additional, and Venton, Geoffroy, additional

Published
2020
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43. Transfusion practices in geriatric short stay unit before and after the French national health authority guidelines of 2014

Author

Pellerey, Magali, additional, Couderc, Anne Laure, additional, Pauly, Vanessa, additional, Gayet, Stephane, additional, Leveque, Pierre, additional, Mizzi, Barbara, additional, Gobin, Nirvina, additional, Caunes, Pierre, additional, Clapasson, Christine, additional, Chiaroni, Jacques, additional, Daumas, Aurelie, additional, and Villani, Patrick, additional

Published
2018
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45. Effect of frailty on unplanned readmission in older adults: A systematic review

Author

Bourriquen, Maryline, Couderc, Anne-Laure, Bretelle, Fannie, and Villani, Patrick

Abstract

Frailty and hospital readmissions are two major problems for older people because of their impact on health, quality of life and healthcare systems. The aims of this study were to investigate the relationship between frailty and unplanned readmissions at 30, 90, 180 days and 1 year in hospitalised older people, and to identify the most relevant tools for assessing readmission risk in different clinical settings to facilitate systematic identification of this high-risk population by healthcare professionals.

Published
2024
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46. Clinical effectiveness of osteoporosis treatment in older patients: A fracture liaison service-based prospective study.

Author

Mugnier, Bénédicte, Daumas, Aurélie, Couderc, Anne-Laure, Mizzi, Barbara, González, Thomas, Amrani, Anne, Lévêque, Pierre, Aymes, Brice, Argenson, Jean-Nöel, and Villani, Patrick

Subjects
BONE fracture prevention, OSTEOPOROSIS prevention, DISEASE relapse prevention, DISEASE relapse, BONE fractures, LONGITUDINAL method, OSTEOPOROSIS, PREVENTIVE health services, TREATMENT effectiveness, DISEASE incidence, DISEASE risk factors, OLD age
Abstract

The clinical efficacy of anti-osteoporotic treatments in old patients is discussed. The aim of this study was to assess if the use of anti-osteoporotic treatments for the secondary prevention of osteoporotic fractures could reduce the risk of refractures in patients over 75 years old in a Fracture Liaison Service. In this population of frail, elderly patients presenting with a recent osteoporotic fracture, we observed that the refracture incidence was similar in the treated group and the untreated group during the first year. However, 30 months after the index fracture, the osteoporosis medication for a year or more reduced the incidence of refractures by 70%. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Pratiques transfusionnelles en court séjour gériatrique avant et après les recommandations de 2014 de la Haute autorité de santé.

Author

Pellerey, Magali, Couderc, Anne Laure, Pauly, Vanessa, Gayet, Stephane, Leveque, Pierre, Mizzi, Barbara, Gobin, Nirvina, Caunes, Pierre, Clapasson, Christine, Chiaroni, Jacques, Daumas, Aurelie, and Villani, Patrick

Abstract

Copyright of Gériatrie et Psychologie Neuropsychiatrie du Vieillissement is the property of John Libbey Eurotext Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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