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4. RWD98 Health Care Resource Use and Costs of Hemophilia A in France

Author

Cahoreau, V., primary, Giraud, N., additional, Delienne, S., additional, Fagnani, F., additional, Bouee, S., additional, Cottin, J., additional, Bureau, I., additional, Rudant, J., additional, Fahfouhi, Y., additional, Martin, L., additional, Lilliu, H., additional, Frenzel, L., additional, and Lebreton, A., additional

Published
2023
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5. EE565 Healthcare Consumption and Costs of Hemophilia B in France

Author

Lilliu, H., primary, Delienne, S., additional, Giraud, N., additional, Fagnani, F., additional, Bouee, S., additional, Cottin, J., additional, Bureau, I., additional, Rudant, J., additional, Fahfouhi, Y., additional, Kachaner, I., additional, Cahoreau, V., additional, Lebreton, A., additional, and Frenzel, L., additional

Published
2023
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16. Assessment of the automated multiplex-PCR Unyvero i60 ITI® cartridge system to diagnose prosthetic joint infection: a multicentre study

Author

Cottin, J., Ducellier, F., Abgueguen, P., Balan, V., Stindel, E., Ansart, S., Greves, A., Aubin, G., Touchais, S., Gouin, F., Boutoille, D., Asseray, N., Happi, L., Guinard, J., Razanabola, F., Mille, C., Cognée, A.S., Gayet, L.E., Le Moal, G., Thomas, C., Polard, J.L., Arvieux, C., Meheut, A., Bernard, L., Rosset, P., Gras, G., Druon, J., Fèvre, K., Malandain, D., Bémer, P., Leroy, A.G., Léger, J., Plouzeau, C., Valentin, A.S., Jolivet-Gougeon, A., Tandé, D., Héry-Arnaud, G., Lemarié, C., Kempf, M., Bret, L., Burucoa, C., and Corvec, S.

Published
2018
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25. PM1-022 Antitumor necrosis factor during the first trimester of pregnancy and congenital malformations : a meta-analysis of etiologic observational studies

Author

gouraud, aurore, Bérard, A., Cucherat, M, Cottin, J., Service Hospitalo-Universitaire de Pharmacologie et Toxicologie - Lyon (SHUPT Lyon), Hospices Civils de Lyon (HCL), Ecologie des Forêts Méditerranéennes (URFM), Institut National de la Recherche Agronomique (INRA), Pharmacie Hospitalière et Pharmacovigilance, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France, parent, Ecologie des Forêts Méditerranéennes [Avignon] (URFM 629), and gouraud, aurore

Subjects
[SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

International audience; Introduction: Over the last decade, antitumor necrosis factor (anti TNF) therapy became the cornerstone management for immune mediated diseases such as inflammatory bowel disease or rheumatoid arthritis. Such conditions predominantly affect women of childbearing age, and a growing number of studies have been published on the safety of anti-TNF therapy during pregnancy. Meta-analyses (MA) could help synthesize findings as well as increase statistical power for rare outcomes such as congenital malformations (CM). Thus, the aim of our work was to assess the risk of CM (major and minor) associated with first trimester exposure to anti TNF using a meta-analytic approach. Material and methods: We conducted a systematic review and MA. Published reports and meeting abstracts were searched for in MEDLINE up to December 2018. We used both MeSH and free text terms to identify relevant articles. Bibliographic reference lists of all identified studies, MA and reviews were hand searched in order to identify additional eligible articles. All comparative cohort and case-control studies reporting data on malformation, and use of anti-TNF during the first trimester were included. An experimented pharmacologist evaluated the eligibility of studies, and extracted data using a proprietary collaborative WEB-based meta-analysis platform (metaPreg.org). The risk of CM between anti-TNF exposed and non-exposed pregnancies, and its 95% confidence interval were estimated using a random effects model. Results: From 1,014 records initially found, 15 studies met eligibility criteria. In addition, the MA was restricted to studies that included diseased unexposed women as a comparator. Ten cohort studies (5 prospective and 5 retrospective), reporting 1,407 exposed, and 6,196 unexposed pregnancies, were included. We included 3 new studies (909 exposed pregnancies) compared to the last published MA on the risk of congenital malformations associated with first trimester exposure to anti-TNF in 2017 (1). First trimester exposure to anti-TNF was not statistically significantly associated with the risk of CM (odd ratio of 0.98 , 95% CI 0.75-1.28). No heterogeneity between studies was observed (I2=0%). Funnel plot and asymmetry test were not suggestive of publication bias. Discussion / Conclusion: We did not find an association between exposure to anti-TNF in pregnancy and an increased risk of CMs. However, a lack of power cannot be ruled out. The risk of CMs after exposure to anti-TNF would be increased at most by by 30%. Reference(s): 1. Komaki et al. J Autoimmun.2017

Published
2019

28. Neuromuscular blocking agents induced anaphylaxis: Results and trends of a French pharmacovigilance survey from 2000 to 2012

Author

Petitpain, N., Argoullon, L., Masmoudi, K., Fedrizzi, S., Cottin, J., Latarche, C., Mertes, P., Pierre GILLET, French Network of Regional Pharmacovigilance Centres Network, Centre Régional de PharmacoVigilance de Lorraine (CRPV Lorraine), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Amiens-Picardie, Centre régional de pharmacovigilance de Caen Basse-Normandie (CRPV), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Pharmacie Hospitalière et Pharmacovigilance, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France, parent, Service d'Epidémiologie et Evaluations Cliniques [CHRU Nancy] (Pôle S2R), CHU Strasbourg, Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)

Subjects
ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2018

29. Neuromuscular Blocking Agents induced anaphylaxis: the French pharmacovigilance experience from 2000 to 2012

Author

Petitpain, Nadine, Mertes, P., Masmoudi, K., Fedrizzi, S, Cottin, J, Yéléhé-Okouma, M., Gillet, Pierre, Centre Régional de PharmacoVigilance de Lorraine (CRPV Lorraine), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and HELLE, Déborah

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2018

35. Assessment of the automated multiplex-PCR Unyvero i60 ITI® cartridge system to diagnose prosthetic joint infection: a multicentre study

Author

Malandain, D., primary, Bémer, P., additional, Leroy, A.G., additional, Léger, J., additional, Plouzeau, C., additional, Valentin, A.S., additional, Jolivet-Gougeon, A., additional, Tandé, D., additional, Héry-Arnaud, G., additional, Lemarié, C., additional, Kempf, M., additional, Bret, L., additional, Burucoa, C., additional, Corvec, S., additional, Cottin, J., additional, Ducellier, F., additional, Abgueguen, P., additional, Balan, V., additional, Stindel, E., additional, Ansart, S., additional, Greves, A., additional, Aubin, G., additional, Touchais, S., additional, Gouin, F., additional, Boutoille, D., additional, Asseray, N., additional, Happi, L., additional, Guinard, J., additional, Razanabola, F., additional, Mille, C., additional, Cognée, A.S., additional, Gayet, L.E., additional, Le Moal, G., additional, Thomas, C., additional, Polard, J.L., additional, Arvieux, C., additional, Meheut, A., additional, Bernard, L., additional, Rosset, P., additional, Gras, G., additional, Druon, J., additional, and Fèvre, K., additional

Published
2018
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37. Ultra-refractory mantle within oceanic plateau: Petrology of the spinel harzburgites from Lac Michèle, Kerguelen Archipelago

Author

Wasilewski, B., Doucet, Luc-Serge, Moine, B., Beunon, H., Delpech, G., Mattielli, N., Debaille, V., Delacour, A., Grï goire, M., Guillaume, D., Cottin, J., Wasilewski, B., Doucet, Luc-Serge, Moine, B., Beunon, H., Delpech, G., Mattielli, N., Debaille, V., Delacour, A., Grï goire, M., Guillaume, D., and Cottin, J.

Abstract

The study presents major and trace element compositions of whole-rocks and minerals of 24 spinel harzburgite xenoliths from the Lac Michèle locality in the northern part of the Kerguelen Archipelago (South Indian Ocean). The samples are modally homogeneous and large enough to provide representative whole-rock samples. Their Mg# are high (0.91 to 0.93) and they have 16–29 wt.% orthopyroxene (opx) and low clinopyroxene contents (0.1–2.8 wt.%). They display a wide range of serpentinisation, which result in LOI contents ranging from 0 to 3.5 wt.%. The spinel-bearing harzburgites from Lac Michèle are the most refractory peridotites identified so far among peridotite xenoliths available on the Kerguelen Archipelago and within the oceanic lithosphere. By contrast with most of the peridotite xenoliths from Kerguelen, they have been more preserved from post-formation processes such as metasomatic processes. The major and trace element compositions of the least serpentinised spinel harzburgites indicate an origin by ~ 30% of polybaric decompression fractional melting between 5GPa and ≤ 1 GPa. Thus, the spinel harzburgites from Lac Michèle, situated at the top of the Kerguelen lithospheric mantle, are residues of melting that took place over a broad range of depth and mostly in the garnet stability field. Our results, in comparison with published data on mantle xenoliths worldwide, show that spinel harzburgites from Lac Michèle have major and modal compositions that fall in the range of cratonic peridotites rather than abyssal peridotites, oceanic island peridotites, subduction zones peridotites and off-cratonic peridotites. This indicates (i) they formed in similar condition as for the ancient continental lithospheric mantle or (ii) they are fragment of ancient continental lithospheric mantle incorporated in the Kerguelen plateau.

Published
2017

39. Multicentre external quality control evaluating universal 16S polymerase chain reaction in the diagnosis of bone and joint infections

Author

Plouzeau, Chloe, Valentin, Anne-Sophie, Héry-Arnaud, Geneviève, Bret, Laurent, Burucoa, Christophe, Cognee, Anne Sophie, Cottin, J, Gibaud, Sophie, Guignard, J, Jolivet-Gougeon, Anne, Kempf, M, Lemarie, C, Quentin, Roland, Tandé, P, Vincent, P, Corvec, Stephane, Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, and Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT)

Subjects
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Microbiology and Parasitology, Médecine humaine et pathologie, Human health and pathology, Microbiologie et Parasitologie, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2013

43. Antimicrobial resistance data on 16,756 Streptococcus pneumoniae isolates in 1999: A pan-regional multicenter surveillance study in France

Author

Demachy, M.C., Vernet-Garnier, V., Cottin, J., Chanal, C., Chardon, H., Chomarat, M., Dupont, Pierre, Fauchère, J.L., Fosse, T., Laaberki, M.F., Laurens, G., Lemozy, J., Maugein, J., Murbach, V., Roussel-Delvallez, M., Thoreux, P.H., Vaucel, J., Vergnaud, M., Weber, M., Ploy, Marie-Cécile, Biologie moléculaire et cellulaire des microorganismes (EA3175), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Limoges (UNILIM), and Bucek, Ingrid

Subjects
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2005

48. Observatoire régional du pneumocoque en région Pays de la Loire : résistance de Streptococcus pneumoniae aux antibiotiques en 2007

Author

Kempf, M., primary, Kowalczyk, F., additional, Gaultier du Perray, C., additional, Andorin, P., additional, Bichier, E., additional, Bonnaudet, G., additional, Chambreuil, G., additional, Cheviet, G., additional, Darreau, J.-Y., additional, De Gastines, G., additional, Jan, D., additional, Jaouen, E., additional, Jouble, F., additional, Juvin, M.-E., additional, Langeard, M.-M., additional, Le Brun, C., additional, Le Reste, J.-Y., additional, Lureau, B., additional, Mir, E., additional, Mozas, M., additional, Tharreau, T., additional, Varache, C., additional, Cottin, J., additional, and Joly-Guillou, M.-L., additional

Published
2010
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