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2. Functional outcomes among young people with trajectories of persistent childhood psychopathology

Author

Dooley, N. (Niamh), Kennelly, B. (Brendan), Arseneault, L. (Louise), Zammit, S. (Stanley), Whelan, R. (Rob), Mosley, O. (Olivia), Cotter, D. (Delia), Clarke, M. (Mary), Cotter, D. R. (David R.), Kelleher, I. (Ian), McGorry, P. (Pat), Healy, C. (Colm), Cannon, M. (Mary), Dooley, N. (Niamh), Kennelly, B. (Brendan), Arseneault, L. (Louise), Zammit, S. (Stanley), Whelan, R. (Rob), Mosley, O. (Olivia), Cotter, D. (Delia), Clarke, M. (Mary), Cotter, D. R. (David R.), Kelleher, I. (Ian), McGorry, P. (Pat), Healy, C. (Colm), and Cannon, M. (Mary)

Abstract

Importance: Understanding which children in the general population are at greatest risk of poor functional outcomes could improve early screening and intervention strategies. Objective: To investigate the odds of poor outcomes in emerging adulthood (ages 17 to 20 years) for children with different mental health trajectories at ages 9 to 13 years. Design, Setting, and Participants: Growing Up in Ireland is a longitudinal, nationally representative population-based cohort study. Data collection began in August 2007 and was repeated most recently in September 2018. All results were weighted to account for sampling bias and attrition and were adjusted for socioeconomic factors. Data analysis took place from October 2022 to April 2023. Exposure: Four latent classes captured variation in mental health in children aged 9 and 13 years, based on the parent-completed Strengths and Difficulties Questionnaire. Classes included no psychopathology, internalizing, externalizing, and high (comorbid) psychopathology. Those who remained in the same class from ages 9 to 13 years were included. Main Outcomes and Measures: Poor functional outcomes in emerging adulthood were measured at approximate ages 17 years (range, 16 to 18 years) and 20 years (range, 19 to 21 years). Outcomes included poor mental health, poor physical health, social isolation, heavy substance use, frequent health service use, poor subjective well-being, and adverse educational/economic outcomes. Results: Of 5141 included participants, 2618 (50.9%) were male. A total of 3726 (72.5%) were classed as having no childhood psychopathology, 1025 (19.9%) as having persistent externalizing psychopathology, 243 (4.7%) as having persistent internalizing psychopathology, and 147 (2.9%) as having persistent high psychopathology. Having any childhood psychopathology was associated with poorer functional outcomes in emerging adulthood. The internalizing group had elevated odds of most outcomes except for heavy substance

Published
2023

11. Recent marine growth declines in wild and ranched Atlantic salmon Salmo salar from a western European catchment discovered using a 62-year time series.

Author

Long, A P, Vaughan, L, Tray, E, Thomas, K, Maoiléidigh, N Ó, Poole, R, Cotter, D, Doogan, A, and Brophy, D

Subjects
ATLANTIC salmon, SALMON farming, TIME series analysis, OCEAN temperature, TIME management
Abstract

To address population declines, many salmon populations are supplemented with hatchery-bred fish. Little is known about how growth performance of hatchery-bred and wild salmon compare during critical periods such as the first summer at sea. This study compares scale growth measurements between 1725 ranched and 1976 wild salmon from the Burrishoole catchment (western Ireland) over 62 years (1956–2017). Post-smolt growth (PSG) was greater in wild than ranched fish; this difference was consistent with compensatory growth rather than size-dependant growth. Temporal trends in marine growth of wild and ranched fish were similar, with a marked decline in PSG and return size after the early 2000s. The decline in PSG was significantly related to freshwater growth and autumn sea surface temperature in the Norwegian Sea. Temporal changes in the pattern of intercirculi spacings along the PSG growth trajectory were also identified; circuli deposited during the first summer at sea were narrower in the 2000s and 2010s compared to earlier decades, while circuli from the first winter were wider. The recent decline in growth affects both populations similarly, is associated with increasing temperature and is manifested as a change in growth pattern as well as overall growth. [ABSTRACT FROM AUTHOR]

Published
2023
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16. The association of plasma inflammatory markers with omega-3 fatty acids and their mediating role in psychotic symptoms and functioning: An analysis of the NEURAPRO clinical trial

Author

Susai, SR, Mongan, D, Healy, C, Cannon, M, Nelson, B, Markulev, C, Schäfer, MR, Berger, M, Mossaheb, N, Schlögelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rössler, A, Verma, S, Thompson, A, Yung, Alison, McGorry, PD, Föcking, M, Cotter, D, Amminger, GP, Susai, SR, Mongan, D, Healy, C, Cannon, M, Nelson, B, Markulev, C, Schäfer, MR, Berger, M, Mossaheb, N, Schlögelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rössler, A, Verma, S, Thompson, A, Yung, Alison, McGorry, PD, Föcking, M, Cotter, D, and Amminger, GP

Published
2022

17. A pharmacogenomic assessment of psychiatric adverse drug reactions to levetiracetam

Author

Campbell, C, McCormack, M, Patel, S, Stapleton, C, Bobbili, D, Krause, R, Depondt, C, Sills, GJ, Koeleman, BP, Striano, P, Zara, F, Sander, JW, Lerche, H, Kunz, WS, Stefansson, K, Stefansson, H, Doherty, CP, Heinzen, EL, Scheffer, IE, Goldstein, DB, O'Brien, T, Cotter, D, Berkovic, SF, Sisodiya, SM, Delanty, N, Cavalleri, GL, Campbell, C, McCormack, M, Patel, S, Stapleton, C, Bobbili, D, Krause, R, Depondt, C, Sills, GJ, Koeleman, BP, Striano, P, Zara, F, Sander, JW, Lerche, H, Kunz, WS, Stefansson, K, Stefansson, H, Doherty, CP, Heinzen, EL, Scheffer, IE, Goldstein, DB, O'Brien, T, Cotter, D, Berkovic, SF, Sisodiya, SM, Delanty, N, and Cavalleri, GL

Abstract

OBJECTIVE: Levetiracetam (LEV) is an effective antiseizure medicine, but 10%-20% of people treated with LEV report psychiatric side-effects, and up to 1% may have psychotic episodes. Pharmacogenomic predictors of these adverse drug reactions (ADRs) have yet to be identified. We sought to determine the contribution of both common and rare genetic variation to psychiatric and behavioral ADRs associated with LEV. METHODS: This case-control study compared cases of LEV-associated behavioral disorder (n = 149) or psychotic reaction (n = 37) to LEV-exposed people with no history of psychiatric ADRs (n = 920). All samples were of European ancestry. We performed genome-wide association study (GWAS) analysis comparing those with LEV ADRs to controls. We estimated the polygenic risk scores (PRS) for schizophrenia and compared cases with LEV-associated psychotic reaction to controls. Rare variant burden analysis was performed using exome sequence data of cases with psychotic reactions (n = 18) and controls (n = 122). RESULTS: Univariate GWAS found no significant associations with either LEV-associated behavioural disorder or LEV-psychotic reaction. PRS analysis showed that cases of LEV-associated psychotic reaction had an increased PRS for schizophrenia relative to contr ols (p = .0097, estimate = .4886). The rare-variant analysis found no evidence of an increased burden of rare genetic variants in people who had experienced LEV-associated psychotic reaction relative to controls. SIGNIFICANCE: The polygenic burden for schizophrenia is a risk factor for LEV-associated psychotic reaction. To assess the clinical utility of PRS as a predictor, it should be tested in an independent and ideally prospective cohort. Larger sample sizes are required for the identification of significant univariate common genetic signals or rare genetic signals associated with psychiatric LEV ADRs.

Published
2022

18. Machine learning based prediction and the influence of complement - Coagulation pathway proteins on clinical outcome: Results from the NEURAPRO trial

Author

Susai, SR, Mongan, D, Healy, C, Cannon, M, Cagney, G, Wynne, K, Byrne, JF, Markulev, C, Schafer, MR, Berger, M, Mossaheb, N, Schlogelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rossler, A, Verma, S, Street, R, Thompson, A, Yung, AR, Nelson, B, McGorry, PD, Focking, M, Amminger, GP, Cotter, D, Susai, SR, Mongan, D, Healy, C, Cannon, M, Cagney, G, Wynne, K, Byrne, JF, Markulev, C, Schafer, MR, Berger, M, Mossaheb, N, Schlogelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rossler, A, Verma, S, Street, R, Thompson, A, Yung, AR, Nelson, B, McGorry, PD, Focking, M, Amminger, GP, and Cotter, D

Abstract

BACKGROUND: Functional outcomes are important measures in the overall clinical course of psychosis and individuals at clinical high-risk (CHR), however, prediction of functional outcome remains difficult based on clinical information alone. In the first part of this study, we evaluated whether a combination of biological and clinical variables could predict future functional outcome in CHR individuals. The complement and coagulation pathways have previously been identified as being of relevance to the pathophysiology of psychosis and have been found to contribute to the prediction of clinical outcome in CHR participants. Hence, in the second part we extended the analysis to evaluate specifically the relationship of complement and coagulation proteins with psychotic symptoms and functional outcome in CHR. MATERIALS AND METHODS: We carried out plasma proteomics and measured plasma cytokine levels, and erythrocyte membrane fatty acid levels in a sub-sample (n = 158) from the NEURAPRO clinical trial at baseline and 6 months follow up. Functional outcome was measured using Social and Occupational Functional assessment Score (SOFAS) scale. Firstly, we used support vector machine learning techniques to develop predictive models for functional outcome at 12 months. Secondly, we developed linear regression models to understand the association between 6-month follow-up levels of complement and coagulation proteins with 6-month follow-up measures of positive symptoms summary (PSS) scores and functional outcome. RESULTS AND CONCLUSION: A prediction model based on clinical and biological data including the plasma proteome, erythrocyte fatty acids and cytokines, poorly predicted functional outcome at 12 months follow-up in CHR participants. In linear regression models, four complement and coagulation proteins (coagulation protein X, Complement C1r subcomponent like protein, Complement C4A & Complement C5) indicated a significant association with functional outcome; and two protei

Published
2022

19. Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis

Author

Susai, SR, Healy, C, Mongan, D, Heurich, M, Byrne, JF, Cannon, M, Cagney, G, Wynne, K, Markulev, C, Schafer, MR, Berger, M, Mossaheb, N, Schlogelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rossler, A, Verma, S, Street, R, Thompson, A, Yung, AR, Nelson, B, McGorry, PD, Focking, M, Amminger, GP, Cotter, D, Susai, SR, Healy, C, Mongan, D, Heurich, M, Byrne, JF, Cannon, M, Cagney, G, Wynne, K, Markulev, C, Schafer, MR, Berger, M, Mossaheb, N, Schlogelhofer, M, Smesny, S, Hickie, IB, Berger, GE, Chen, EYH, de Haan, L, Nieman, DH, Nordentoft, M, Riecher-Rossler, A, Verma, S, Street, R, Thompson, A, Yung, AR, Nelson, B, McGorry, PD, Focking, M, Amminger, GP, and Cotter, D

Abstract

Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates the molecular mechanism of omega-3 PUFA-associated therapeutic effects in clinical high-risk (CHR) participants. Plasma samples of 126 CHR psychosis participants at baseline and 6-months follow-up were included. Plasma protein levels were quantified using mass spectrometry and erythrocyte omega-3 PUFA levels were quantified using gas chromatography. We examined the relationship between change in polyunsaturated PUFAs (between baseline and 6-month follow-up) and follow-up plasma proteins. Using mediation analysis, we investigated whether plasma proteins mediated the relationship between change in omega-3 PUFAs and clinical outcomes. A 6-months change in omega-3 PUFAs was associated with 24 plasma proteins at follow-up. Pathway analysis revealed the complement and coagulation pathway as the main biological pathway to be associated with change in omega-3 PUFAs. Moreover, complement and coagulation pathway proteins significantly mediated the relationship between change in omega-3 PUFAs and clinical outcome at follow-up. The inflammatory protein complement C5 and protein S100A9 negatively mediated the relationship between change in omega-3 PUFAs and positive symptom severity, while C5 positively mediated the relationship between change in omega-3 and functional outcome. The relationship between change in omega-3 PUFAs and cognition was positively mediated through coagulation factor V and complement protein C1QB. Our findings provide evidence for a longitudinal association of omega-3 PUFAs with complement and coagulation protein changes in the blood. Further, the results suggest that an increase in omega-3 PUFAs decreases symptom severity and improves cognition in the CHR state through modulating effects of complement and coagulation proteins.

Published
2022

29. A short report of satisfaction levels amongst Irish trainees in psychiatry with out of hours and emergency assessments

Author

O’Donovan, D., McGrane, J., Barry, H., Cannon, M., and Cotter, D.

Abstract

Objectives:On-call and crisis psychiatry is a very challenging aspect of psychiatric training. This study aimed to describe the experiences of psychiatric trainees on-call in hospitals, emergency departments and psychiatric units in Ireland.Methods:In total, 193 psychiatric trainees in Ireland were emailed a survey in 2017. The survey included questions regarding the duties expected of the trainee, frequency of on-call obligations, un-rostered hours worked, level of senior support, assessment facilities available and doctors’ satisfaction with the on-call experience.Results:Overall, 68 trainees responded to the survey. In total, 35% of respondents reported dissatisfaction with their experience of on-call and crisis psychiatry, 46% reported that they were not provided with training in risk assessment and 21% of respondents stated that there was not a suitable room available to perform their assessments.Conclusions:This survey has raised important issues facing those on the frontline of psychiatric services in Ireland. Of particular concern are resource issues faced by trainees and the need for further training and support related to risk assessment when on-call. Remedying these issues may lead to a decreased rate of dropout as well as a safer and better environment for patients and doctors alike.

Published
2023
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32. Cannabidiol for at risk for psychosis youth: A randomized controlled trial

Author

Amminger, GP, Lin, A, Kerr, M, Weller, A, Spark, J, Pugh, C, O'Callaghan, S, Berger, M, Clark, SR, Scott, JG, Baker, A, McGregor, I, Cotter, D, Sarnyai, Z, Thompson, A, Yung, AR, O'Donoghue, B, Killackey, E, Mihalopoulos, C, Yuen, HP, Nelson, B, McGorry, PD, Amminger, GP, Lin, A, Kerr, M, Weller, A, Spark, J, Pugh, C, O'Callaghan, S, Berger, M, Clark, SR, Scott, JG, Baker, A, McGregor, I, Cotter, D, Sarnyai, Z, Thompson, A, Yung, AR, O'Donoghue, B, Killackey, E, Mihalopoulos, C, Yuen, HP, Nelson, B, and McGorry, PD

Abstract

BACKGROUND: No biological treatment has been firmly established for the at-risk stage of psychotic disorder. In this study we aim to test if subthreshold psychotic symptoms can be effectively treated with cannabidiol (CBD), a non-psychoactive compound of the plant Cannabis sativa. The question has taken on increased importance in the wake of evidence questioning both the need and efficacy of specific pharmacological interventions in the ultra-high risk (UHR) for psychosis group. METHODS: Three-arm randomized controlled trial of 405 patients (135 per arm) aged 12-25 years who meet UHR for psychosis criteria. The study includes a 6-week lead-in phase during which 10% of UHR individuals are expected to experience symptom remission. Participants will receive CBD (per oral) at doses 600 or 1000 mg per day (fixed schedule) for 12 weeks. Participants in the third arm of the trial will receive matching placebo capsules. Primary outcome is severity of positive psychotic symptoms as measured by the Comprehensive Assessment of At-Risk Mental States at 12 weeks. We hypothesize that CBD will be significantly more effective than placebo in improving positive psychotic symptoms in UHR patients. All participants will also be followed up 6 months post baseline to evaluate if treatment effects are sustained. CONCLUSION: This paper reports on the rationale and protocol of the Cannabidiol for At Risk for psychosis Youth (CanARY) study. This study will test CBD for the first time in the UHR phase of psychotic disorder.

Published
2021

38. T21. DEVELOPMENT OF PROTEOMIC PREDICTION MODELS FOR OUTCOMES IN THE CLINICAL HIGH RISK STATE AND PSYCHOTIC EXPERIENCES IN ADOLESCENCE: MACHINE LEARNING ANALYSES IN TWO NESTED CASE-CONTROL STUDIES

Author

Mongan, D, Föcking, M, Healy, C, Raj Susai, S, Cagney, G, Cannon, M, Zammit, S, Nelson, B, McGorry, P, Nordentoft, M, Krebs, M-O, Riecher-Rössler, A, Bressan, R, Barrantes-Vidal, N, Borgwardt, S, Ruhrmann, S, Sachs, G, Van der Gaag, M, Rutten, B, Pantelis, C, De Haan, L, Valmaggia, L, Kempton, M, McGuire, P, Cotter, D, Mongan, D, Föcking, M, Healy, C, Raj Susai, S, Cagney, G, Cannon, M, Zammit, S, Nelson, B, McGorry, P, Nordentoft, M, Krebs, M-O, Riecher-Rössler, A, Bressan, R, Barrantes-Vidal, N, Borgwardt, S, Ruhrmann, S, Sachs, G, Van der Gaag, M, Rutten, B, Pantelis, C, De Haan, L, Valmaggia, L, Kempton, M, McGuire, P, and Cotter, D

Published
2020

49. National Scientific Medical Meeting 1994 Abstracts

Author

Carson, K. D., Grimes, S. B., McGinley, J. M., Thornton, M. T., Mulhall, J., Bourke, A. M., McCrory, C., Marsh, B., Hone, R., Phelan, D., White, M., Fabry, J., Hughes, D., Carson, K., Donnelly, M., Shanahan, E., Fitzpatrick, G. J., Bourke, M., Warde, D., Buggy, D., Hughes, N., Taylor, A., Dowd, N., Markham, T., Blunnie, W., Nicholson, G., O’Leary, E., Cunningham, A. J., Dwyer, R., McMechan, S., Cullen, C., Dempsey, G., Wright, G., MacKenzie, G., Anderson, J., Adgey, J., Walsh, M., O’Callaghan, P., Graham, I., O’Hare, J. A., Geoghegan, M., Iman, N., Shah, P., Chander, R., Lavin, F., Daly, K., Johnston, P. W., Imam, Z., Adgey, A. A. J., Rusk, R. A., Richardson, S. G., Hale, A., Kinsella, B. M., FitzGerald, G. A., King, G., Crean, P., Gearty, G., Cawley, T., Docherty, J. R., Geraghty, J., Osborne, H., Upton, J., D’Arcy, G., Stinson, J., Cooke, T., Colgan, M. P., Hall, M., Tyrrell, J., Gaffney, K., Grouden, M., Moore, D. J., Shanik, G., Feely, J., Delanty, N., Reilly, M., Lawson, J. A., Fitzgerald, D. J., Reilly, M. P., McAdam, B. F., Bergin, C., Walshe, M. J., Herity, N. A., Allen, J. D., Silke, B., Singh, H. P., O’Neill, S., Hargrove, M., Coleman, E., Shorten, E., Aherne, T., Kelly, B. E., Hill, D. H., McIlrath, E., Morrow, B. C., Lavery, G. G., Blackwood, B., Fee, J. P. H., Kevin, L., Doran, M., Tansey, D., Boylan, I., McShane, A. J., O’Reilly, G., Tuohy, B., Grainger, P., Larkin, T., Mahady, J., Malone, J., Condon, C., Donoghue, T., O’Leary, J., Lyons, J. F., Tay, Y. K., Tham, S. N., Khoo Tan, H. S., Gibson, G., O’Grady, A., Leader, M., Walshe, J., Carmody, M., Donohoe, J., Murphy, G. M., O’Connor, W., Barnes, L., Watson, R., Darby, C., O’Moore, R., Mulcahy, F., O’Toole, E., O’Briain, D. S., Young, M. M., Buckley, D., Healy, E., Rogers, S., Ni Scannlain, N., McKenna, M. J., McBrinn, Y., Murray, B., Freaney, R., Barrett, E., Razza, Q., Abuaisha, F., Powell, D., Murray, T. M., Powell, A. M., O’Mongain, E., O’Neill, J., Kernan, R. P., O’Connor, P., Clarke, D., Fearon, U., Cunningham, S. K., McKenna, T. J., Hayes, F., Heffernan, A., Sheahan, K., Harper, R., Johnston, G. D., Atkinson, A. B., Sheridan, B., Bell, P. M., Heaney, A. P., Loughrey, G., McCance, D. R., Hadden, D. R., Kennedy, A. L., McNamara, P., O’Shaughnessy, C., Loughrey, H. C., Reid, I., Teahan, S., Caldwell, M., Walsh, T. N., McSweeney, J., Hennessy, T. P., Caldwell, M. T. P., Byrne, P. J., Hennessy, T. P. J., El-Magbri, A. A., Stevens, F. M., O’Sullivan, R., McCarthy, C. F., Laundon, J., Heneghan, M. A., Kearns, M., Goulding, J., Egan, E. L., McMahon, B. P., Hegarty, F., Malone, J. F., Merriman, R., MacMathuna, P., Crowe, J., Lennon, J., White, P., Clarke, E., Prabhakar, M. C., Ryan, E., Graham, D., Yeoh, P. L., Kelly, P., McKeogh, D., O’Keane, C., Kitching, A., Mulligan, E., Gorey, T. F., Mahmud, N., O’Connell, M., Goggins, M., Keeling, P. W. N., Weir, D. G., Kelleher, D., McDonald, G. S. A., Maguire, D., O’Sullivan, G., Harvey, B., Cherukuri, A., McGrath, J. P., Timon, C., Lawlor, P., O’Shea, J., Buckley, M., English, L., Walsh, T., O’Morain, C., Lavelle, S. M., Kanagaratnam, B., Harding, B., Murphy, B., Kavanagh, J., Kerr, D., Lavelle, E., O’Gorman, T., Liston, S., Fitzpatrick, C., Fitzpatrick, P., Turner, M., Murphy, A. W., Cafferty, D., Dowling, J., Bury, G., Kaf Al-Ghazal, S., Zimmermann, E., O’Donoghue, J., McCann, J., Sheehan, C., Boissel, L., Lynch, M., Cryan, B., Fanning, S., O’Meara, D., Fennell, J., Byrne, P. M., Lyons, D., Mulcahy, R., Pooransingh, A., Walsh, J. B., Coakley, D., O’Neill, D., Ryall, N., Connolly, P., Namushi, R., Lawler, M., Locasciulli, A., Bacigalupo, A., Humphries, P., McCann, S. R., Pamphilon, D., Reidy, M., Madden, M., Finch, T., Borton, M., Barnes, C. A., Lawlor, S. E., Gardiner, N., Egan, L. J., Orren, A., Doherty, J., Curran, C., O’Hanlon, D., Kent, P., Kerin, M., Maher, D., Given, H. F., Lynch, S., McManus, R., O’Farrelly, C., Madrigal, L., Feighery, C., O’Donoghue, D., Whelan, C. A., Rea, I. M., Stewart, M., Campbell, P., Alexander, H. D., Crockard, A. D., Morris, T. C. M., Maguire, H., Davidson, F., Kaminski, G. Z., Butler, K., Hillary, I. B., Parfrey, N. A., Crowley, B., McCreary, C., Keane, C., O’Reilly, M., Goh, J., Kennedy, M., Fitzgerald, M., Scott, T., Murphy, S., Hildebrand, J., Holliman, R., Smith, C., Kengasu, K., Riain, U. Ni, Cormican, M., Flynn, J., Glennon, M., Smith, T., Whyte, D., Keane, C. T., Barry, T., Noone, D., Maher, M., Dawson, M., Gilmartin, J. J., Gannon, F., Eljamel, M. S., Allcut, D., Pidgeon, C. N., Phillips, J., Rawluk, D., Young, S., Toland, J., Deveney, A. M., Waddington, J. L., O’Brien, D. P., Hickey, A., Maguire, E., Phillips, J. P., Al-Ansari, N., Cunney, R., Smyth, E., Sharif, S., Eljamel, M., Pidgeon, C., Maguire, E. A., Burke, E. T., Staunton, H., O’Riordan, J. I., Hutchinson, M., Norton, M., McGeeney, B., O’Connor, M., Redmond, J. M. T., Feely, S., Boyle, G., McAuliffe, F., Foley, M., Kelehan, P., Murphy, J., Greene, R. A., Higgins, J., Darling, M., Byrne, P., Kondaveeti, U., Gordon, A. C., Hennelly, B., Woods, T., Harrison, R. F., Geary, M., Sutherst, J. R., Turner, M. J., DeLancey, J. O. L, Donnelly, V. S., O’Connell, P. R., O’Herlihy, C., Barry-Kinsella, C., Sharma, S. C., Drury, L., Lewis, S., Stratton, J., Ni Scanaill, S., Stuart, B., Hickey, K., Coulter-Smith, S., Moloney, A., Robson, M. S., Murphy, M., Keane, D., Stronge, J., Boylan, P., Gonsalves, R., Blankson, S., McGuinness, E., Sheppard, B., Bonnar, J., MacDonagh-White, C. M., Kelleher, C. C., Newell, J., White, O., Young, Y., Hallahan, C., Carroll, K., Tipton, K., McDermott, E. W., Reynolds, J. V., Nolan, N., McCann, A., Rafferty, R., Sweeney, P., Carney, D., O’Higgins, N. J., Duffy, M. J., Grimes, H., Gallagher, S., O’Hanlon, D. M., Strattan, J., Lenehan, P., Robson, M., Cusack, Y. A., O’Riordain, D., Mercer, P. M., Smyth, P. P. A., Gallagher, H. J., Moule, B., Cooke, T. G., McArdle, C. S., Burke, C., Vance, A., Saidtéar, C., Early, A., Eustace, P., Maguire, L., Cullinane, A. B. P., Prosser, E. S., Coca-Prados, M., Harvey, B. J., Saidléar, C., Orwa, S., Fitzsimons, R. B., Bradley, O., Hogan, M., Zimmerman, L., Wang, J., Kuliszewski, M., Liu, J., Post, M., Premkumar, Conran, M. J., Nolan, G., Duff, D., Oslizlok, P., Denham, B., O’Connell, P. A, Birthistle, K., Hitchcock, R., Carrington, D., Calvert, S., Holmes, K., Smith, D. F., Hetherton, A. M., Mott, M. G., Oakhill, A., Foreman, N., Foot, A., Dixon, J., Walsh, S., Mortimer, G., O’Sullivan, C., Kilgallen, C. M., Sweeney, E. C., Brayden, D. J., Kelly, J. G., McCormack, P. M. E., Hayes, C., Johnson, Z., Dack, P., Hosseini, J., O’Connell, T., Hemeryck, L., Condren, L., McCormack, P., McAdam, B., Lawson, J., Keimowitz, R., O’Leary, A., Pilkington, R., Adebayo, G. I., Gaffney, P., McGettigan, P., McManus, J., O’Shea, B., Wen, Y., Killalea, S., Golden, J., Swanwick, G., Clare, A. W., Mulvany, F., Byrne, M., O’Callaghan, E., Byrne, H., Cannon, N., Kinsella, T., Cassidy, B., Shepard, N., Horgan, R., Larkin, C., Cotter, D., Coffey, V. P., Sham, P. C., Murray, L. H., Lane, A., Kinsella, A., Murphy, P., Colgan, K., Sloan, D., Gilligan, P., McEnri, J., Ennis, J. T., Stack, J., Corcoran, E., Walsh, D., Thornton, L., Temperley, I., Lawlor, E., Tobin, A., Hillary, I., Nelson, H. G., Martin, M., Ryan, F. M., Christie, M. A., Murray, D., Keane, E., Holmes, E., Hollyer, J., Strangeways, J., Foster, P., Stanwell-Smith, R., Griffin, E., Conlon, T., Hayes, E., Clarke, T., Fogarty, J., Moloney, A. C., Killeen, P., Farrell, S., Clancy, L., Hynes, M., Conlon, C., Foley-Nolan, C., Shelley, E., Collins, C., McNamara, E., Hayes, B., Creamer, E., LaFoy, M., Costigan, P., Al fnAnsari, N., Cunney, R. J., Smyth, E. G., Johnson, H., McQuoid, G., Gilmer, B., Browne, G., Keogh, J. A. B., Jefferson, A, Smith, M., Hennessy, S., Burke, C. M., Sreenan, S., Power, C. K., Pathmakanthan, S., Poulter, L. W., Chan, A., Sheehan, M., Maguire, M., O’Connor, C. M., FitzGerald, M. X., Southey, A., Costello, C. M., McQuaid, K., Urbach, V., Thomas, S., Horwitz, E. R., Mulherin, D., FitzGerald, O., Bresnihan, B., Kirk, G., Veale, D. J., Belch, J. J. F., Mofidi, A., Mofidi, R., Quigley, C., McLaren, M., Veale, D., D’Arrigo, C., Couto, J. Candal, Woof, J., Greer, M., Cree, I., Belch, J., Hone, S., Fenton, J., Hamilton, S., and McShane, D.

Published
1994
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50. Inaugural national scientific medical meeting

Author

Cooke, T. T., Sheahan, R., Foley, D., D’Arcy, G., Gibney, M., Jauch, W., Gearty, G., Crean, P., Walsh, M., Murchan, P. M., O’Donoghue, M. K., Marks, P., Leen, E. J., Shanik, G. D., Feely, T. M., O’Riordan, J., Kellett, J. G., Sheahan, N. F., MacMahon, M., Colgan, M., Walsh, J. B., .Shanik, G, Moore, R., Malone, J. F., Coakley, D., Subareddy, K., Hurley, J., McGovern, E., Sullivan, P. A., O’Mahony, S., Carroll, K., Chua, A., Keeling, R. W. N., O’Kane, A., Dinan, T., Collins, J. K., O’Sullivan, G., Hahnvajanawong, C., McCarthy, M., O’Brien, F., Collins, R. A., Beattie, S., Hamilton, H., O’Morain, C. A., Lynch, S., Murphy, A., Weir, D. G., Feighery, C., O’Farrelly, C., Kelleher, D., Murphy, D., O’Brien, M., Harte, P., Shahi, C. N., Fan, X. J., Huang, J., Smyth, C. J., McDevitt, J., Keeling, P. W. N., Cleary, M., Morrow, G., O’Loughlin, S., Murphy, G. M., Elder, G., Abouzakouk, M., Casey, E., Veale, D., Fitzgerald, O., Bradford, A., O’Regan, R. G., Nolan, P., McKeogh, D., Howell, F., O’Connor, C. M., Rook, G., FitzGerald, M. X., Power, C., Sreenan, S., Poulter, L. W., Burke, C. M., Shanahan, P., O’Donnell, N., Birthistle, K., O’Mahony, M., Shattock, A. G., Hillery, I. B., Bolger, C., Sheehan, N., Hutchinson, M., Phillips, J. P., Malone, J., Esmonde, T. F. G., Will, R. G., Faller, D., Ryan, M. P., Manning, B., Martin, F., McCormack, P. M. E., McGrath, A., Lawlor, R., Donegan, C., Boyce, C., O’Neill, D., Smith, S., Moloney, C., Feely, J., Stanton, A., Atkins, N., O’Brien, E., O’Malley, K., Gough, D. B., Jordan, A., Mannick, J. A., Rodrick, M. L., McCarthy, E., Cooney, C. M., Bourke, J., Phelan, D. M., Robertson, A. M., McShane, A. J., Buggy, D., Breathnach, A., Keogh, B., Coole†, T., Behan, P. O., Cavanagh, H. M. A., Gow, J. W., Simpson, K., Behan, W. M. H., Foley, M., Firth, R., Stronge, J., Bonnar, J., Sheppard, B. L., McClelland, R. J., Watson, D. R., Lawless, V., Houston, H. G., Adams, D., Fitzpatrick, C., Keary, K., Jennings, S., Matthews, T. G., Gormally, S., O’Regan, M., Ward, O. C., Kehoe, S., Luesley, D., Chan, K., Ward, K., Cox, M., Caird, J., Owens, D., Gilligan, S., McBrinn, S., Collins, P., Johnson, A., Tomkin, G., Fiad, T. M., Culliton, M., McKenna, T. J., Collins, P. B., Tomkin, G. H., Stinson, J. C., Clancy, L., Shannon, A., Lucey, M., Cooney, M., Stinson, J., Corcoran, P., Kelly, P., Hayes, C., Laffoy, M., McKnight, J. A., McCance, D. R., O’Hare, F., Wisdom, B., Hayes, J. R., Thornton, L., Fogarty, J., O’Flanagan, D., Corcoran, R., O’Mahony, D., Rowan, M., Clyne, M. G., Duffy, M. J., Davis, M., Kelly, D. G., Quinlan, D. M., Corbally, N., Keane, M. M., Grogan, L., Dervan, P. A., Carney, D. N., Duffy, K., Nugent, A., McDermott, E. W. M., O’Higgins, N. J., Fennelly, J. J., Atkinson, A. B., Ferrett, C. G., Leslie, H., Mcllrath, E. M., Ritchie, C. M., Russell, C. F. J., Sheridan, B., Bashyam, M., O’Sullivan, N., Baker, H., Duggan, P. F., Mitchell, T. H., Beatty, O., Browne, J., Clarke, K., Bell, P. M., Devlin, J. G., Laski, J., O’Neill, S., Redington, F., Dominique, A. V., Scanlan, P., Firth, R. G. R., Fiad, T., Freaney, R., Murray, B., McKenna, M. J., Murphy, J., Love, Wm. C., Cunningham, S. K., Crothers, J. G., McIlrath, E., Chiardha, F. Ni, Gebruers, E. M., Hall, W. J., Hegarty, D. A., O’Hare, J., Geoghegan, M., Abuaisha, F., Passmore, A. P., Whitehead, E. M., Crawford, V., Johnson, G. D., Gallagher, H. G., Stokes, M., Plank, L., Knight, G., Mitra, S., Hill, G., Buckley, P., O’Callaghan, E., Redmond, O., Stack, J. T., Ennis, J. T., Waddington, J. L., Larkin, C., Cannon, M., Byrne, M., Cotter, D., Sham, P., Colgan, K., Walsh, D., Gillian, A. M., Byrne, N., Breen, K. C., Lane, A., Mulvaney, F., Wadding-ton, J. L., Walsh, D., Lawlor, B. A., Colohan, H. A., Walshe, D., Gibson, T., Ronayne, E., Maguire, T. M., Staunton, H., Coughlin, A., Ming, P. Shu, Phillips, J., Youssef, H. A., Adebayo, G., Feely, G., Daly, S. A., Fennell, J. S., Coakley, F., Johnson, Z., Hall, M., McCormack, P. M., Martin, M., O’Connor, M., Curley, P., O’Connell, Y., Mulryan, G., Meenan, E., Kelly, J., Kilfeather, S., Cotter, T., McGlynn, H., Gharbháin, F. Ó, Chambers, P. L., Campbell, H., Stout, R. W., Hegarty, V., Scott, T., Keane, C. T., Healy, M., O’Moore, R. R., Coakley, D., Mulkerin, E., Brain, A., Hampton, D., Penney, M., Woodhouse, K., and Treacy, F.

Published
1993
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