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263 results on '"Coto‐Segura, Pablo"'

1. Efficacy and safety of delgocitinib cream in adults with moderate to severe chronic hand eczema (DELTA 1 and DELTA 2): results from multicentre, randomised, controlled, double-blind, phase 3 trials

Author

Lynde, Charles, Guenther, Lyn, Sauder, Maxwell, Bissonnette, Robert, Rao, Jaggi, Day, Isaiah, Devani, Alim, Metelitsa, Andrei, Grewal, Parbeer, Molin, Sonja, Ruer-Mulard, Mireille, Giordano-Labadie, Françoise, Maillard, Hervé, Reguiai, Ziad, Bernier, Claire, Leleu, Camille, Seneschal, Julien, Staumont-Sallé, Delphine, Hubiche, Thomas, Jacobzone, Caroline, Khemis, Abdallah, Crépy, Marie-Noëlle, Worm, Margitta, Bauer, Andrea, Sell, Sabine, Ekanayake-Bohlig, Swarna, Pauser, Sylvia, Buhl, Timo, Schwinn, Andreas, Eberlein, Bernadette, Quist, Sven, Bauer, Boris, Peris, Ketty, Rossi, Maria Teresa, Fargnoli, Maria, Naldi, Luigi, Stingeni, Luca, Ferrucci, Silvia, Walecka-Herniczek, Irena, Krasowska, Dorota, Lesiak, Aleksandra, Okuniewska, Aleksandra, Pulka, Grażyna, Dyczek, Malgorzata, Kwiek, Bartlomiej, Czajkowski, Rafal, Myśliwiec, Hanna, Mohandas, Padma, Cliff, Sandeep, Warren, Richard, Cousen, Pippa, Johnston, Graham, Woolf, Richard, Papp, Kim, Adam, David, Toth, Darryl, Hong, Chih-ho, Turchin, Irina, Niakosari, Firouzeh, Poulos, Elena, Rivers, Jason, Ohayon, Jason, Gooderham, Melinda, Tjioe, Milan, Rustemeyer, Thomas, de Bruin-Weller, Marjolein S., Schuttelaar, Marie L.A., Molhoek, Judith, Oosting, Bert, Pinter, Andreas, Kaspari, Markus, Magnolo, Nina, Sebastian, Michael, Thaci, Diamant, Schliemann, Sibylle, Radny, Peter, Leitz, Nicolas, Tsianakas, Athanasios, Yazdi, Amir, Kamstrup, Maria, Sommerlund, Mette, Zachariae, Claus, Owczarek, Witold, Dudra-Jastrzebska, Monika, Reich, Adam, Kowalska-Oledzka, Elzbieta, Szepietowski, Jacek, Poznanska, Maria, Weglowska, Jolanta, Aerts, Olivier, Roquet-Gravy, Pierre-Paul, Lanssens, Sven, Castelijns, Francisca, Scheers, Christelle, Suys, Erwin, Kint, Bernard, Serra-Baldrich, Esther, Carrascosa, José Manuel, de la Cueva Dobao, Pablo, Izu, Rosa, Silvestre, Juan Francisco, Coto-Segura, Pablo, Fernández-Orland, Almudena, Warren, Richard B, Agner, Tove, Schuttelaar, Marie L A, Baranowski, Keith, Korn, Sofie, Kurvits, Merle, Plohberger, Ursula, and Strange Vest, Natacha

Published
2024
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2. Multicenter Retrospective Study of Secukinumab Drug Survival in Psoriasis Patients in a Daily Practice Setting: A Long-Term Experience in Spain

Author

Daudén, Esteban, de Lima, Glauber Pacelli Gomes, Armesto, Susana, Herrera-Acosta, Enrique, Vidal, David, Villarasa, Eva, Rivera, Raquel, de la Cueva, Pablo, Martorell, Antonio, Ballesca, Ferran, Belinchón, Isabel, Carretero, Gregorio, Rodríguez, Lourdes, Romero-Maté, Alberto, Pujol-Montcusí, Josep, Salgado, Laura, Sahuquillo-Torralba, Antonio, Coto-Segura, Pablo, Baniandrés, Ofelia, Feltes, Rosa, Alsina, Mercé, and Llamas-Velasco, Mar

Published
2021
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3. Dose reduction is a feasible strategy in patients with plaque psoriasis who achieve sustained response with secukinumab: a retrospective, multicenter cohort study in daily practice setting

Author

Daudén, Esteban, primary, Escario, Elena, additional, Martos‐Cabrera, Luisa, additional, Armesto, Susana, additional, Herrera‐Acosta, Enrique, additional, Vidal, David, additional, Vilarrasa, Eva, additional, Rivera, Raquel, additional, de la Cueva, Pablo, additional, Martorell, Antonio, additional, Ballesca, Ferran, additional, Belinchón, Isabel, additional, Carretero, Gregorio, additional, Rodríguez, Lourdes, additional, Romero‐Maté, Alberto, additional, Pujol‐Montcusí, J., additional, Salgado, Laura, additional, Sahuquillo‐Torralba, Antonio, additional, Coto‐Segura, Pablo, additional, Baniandrés, Ofelia, additional, Feltes, R., additional, Riera‐Monroig, Josep, additional, Garrido, Jesus, additional, and Llamas‐Velasco, Mar, additional

Published
2024
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4. Efficacy and safety of delgocitinib cream in adults with moderate to severe chronic hand eczema (DELTA 1 and DELTA 2): results from multicentre, randomised, controlled, double-blind, phase 3 trials

Author

Bissonnette, Robert, Warren, Richard B, Pinter, Andreas, Agner, Tove, Gooderham, Melinda, Schuttelaar, Marie L A, Crépy, Marie-Noëlle, Stingeni, Luca, Serra-Baldrich, Esther, Baranowski, Keith, Korn, Sofie, Kurvits, Merle, Plohberger, Ursula, Strange Vest, Natacha, Schliemann, Sibylle, Lynde, Charles, Guenther, Lyn, Sauder, Maxwell, Bissonnette, Robert, Rao, Jaggi, Day, Isaiah, Devani, Alim, Metelitsa, Andrei, Grewal, Parbeer, Molin, Sonja, Ruer-Mulard, Mireille, Giordano-Labadie, Françoise, Maillard, Hervé, Reguiai, Ziad, Bernier, Claire, Leleu, Camille, Seneschal, Julien, Staumont-Sallé, Delphine, Hubiche, Thomas, Jacobzone, Caroline, Khemis, Abdallah, Crépy, Marie-Noëlle, Worm, Margitta, Bauer, Andrea, Sell, Sabine, Ekanayake-Bohlig, Swarna, Pauser, Sylvia, Buhl, Timo, Schwinn, Andreas, Eberlein, Bernadette, Quist, Sven, Bauer, Boris, Peris, Ketty, Rossi, Maria Teresa, Fargnoli, Maria, Naldi, Luigi, Stingeni, Luca, Ferrucci, Silvia, Walecka-Herniczek, Irena, Krasowska, Dorota, Lesiak, Aleksandra, Okuniewska, Aleksandra, Pulka, Grażyna, Dyczek, Malgorzata, Kwiek, Bartlomiej, Czajkowski, Rafal, Myśliwiec, Hanna, Mohandas, Padma, Cliff, Sandeep, Warren, Richard, Cousen, Pippa, Johnston, Graham, Woolf, Richard, Papp, Kim, Adam, David, Toth, Darryl, Hong, Chih-ho, Turchin, Irina, Niakosari, Firouzeh, Poulos, Elena, Rivers, Jason, Ohayon, Jason, Gooderham, Melinda, Tjioe, Milan, Rustemeyer, Thomas, de Bruin-Weller, Marjolein S., Schuttelaar, Marie L.A., Molhoek, Judith, Oosting, Bert, Pinter, Andreas, Kaspari, Markus, Magnolo, Nina, Sebastian, Michael, Thaci, Diamant, Schliemann, Sibylle, Radny, Peter, Leitz, Nicolas, Tsianakas, Athanasios, Yazdi, Amir, Kamstrup, Maria, Sommerlund, Mette, Zachariae, Claus, Owczarek, Witold, Dudra-Jastrzebska, Monika, Reich, Adam, Kowalska-Oledzka, Elzbieta, Szepietowski, Jacek, Poznanska, Maria, Weglowska, Jolanta, Aerts, Olivier, Roquet-Gravy, Pierre-Paul, Lanssens, Sven, Castelijns, Francisca, Scheers, Christelle, Suys, Erwin, Kint, Bernard, Serra-Baldrich, Esther, Carrascosa, José Manuel, de la Cueva Dobao, Pablo, Izu, Rosa, Silvestre, Juan Francisco, Coto-Segura, Pablo, and Fernández-Orland, Almudena

Abstract

Chronic hand eczema is a fluctuating, inflammatory, pruritic, often painful disease of hands and wrists that strongly impacts quality of life and occupational capabilities of patients. The aim of phase 3 DELTA 1 and DELTA 2 was to assess the efficacy and safety of twice-daily applications of the topical pan-Janus kinase inhibitor delgocitinib cream 20 mg/g versus cream vehicle in adults with moderate to severe chronic hand eczema.

Published
2024
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5. High rates of tuberculin skin test positivity due to methotrexate therapy: False positive results?

Author

Arias-Guillén, Miguel, Sánchez Menéndez, Marta M., Alperi, Mercedes, Riestra, Sabino, González Budiño, María Teresa, García-Clemente, Marta María, Martínez-González, Susana, Enríquez, Ana Isabel, Alonso-Arias, Rebeca, Palacios Gutiérrez, Juan José, Santibáñez, Miguel, Coto-Segura, Pablo, Camblor, Pablo Martínez, García-Alfonso, Lucía, Morante, Isla, and Escalante, Patricio

Published
2018
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9. A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

Author

Coto-Segura, Pablo, primary, Segú-Vergés, Cristina, additional, Martorell, Antonio, additional, Moreno-Ramírez, David, additional, Jorba, Guillem, additional, Junet, Valentin, additional, Guerri, Filippo, additional, Daura, Xavier, additional, Oliva, Baldomero, additional, Cara, Carlos, additional, Suárez-Magdalena, Olaya, additional, Abraham, Sonya, additional, and Mas, José Manuel, additional

Published
2023
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13. The IFIH1 / MDA5 rs1990760 Gene Variant (946Thr) Differentiates Early- vs. Late-Onset Skin Disease and Increases the Risk of Arthritis in a Spanish Cohort of Psoriasis.

Author

Coto-Segura, Pablo, Vázquez-Coto, Daniel, Velázquez-Cuervo, Lucinda, García-Lago, Claudia, Coto, Eliecer, and Queiro, Rubén

Subjects
*SKIN diseases, *GENETIC variation, *PSORIASIS, *PSORIATIC arthritis, *ARTHRITIS
Abstract

The melanoma differentiation-associated protein 5 (MDA5; encoded by the IFIH1 gene) mediates the activation of the interferon pathway in response to a viral infection. This protein is also upregulated in autoimmune diseases and psoriasis skin lesions. IFIH1 gene variants that increase MDA5 activity have been associated with an increased risk for immune-mediated diseases, including psoriasis. Our aim is to determine the association between three IFIH1 variants (rs35337543 G/C, intron8 + 1; rs35744605 C/A, Glu627Stop; and rs1990760 C/T, Ala946Thr) and the main clinical findings in a cohort of Spanish patients with psoriasis (N = 572; 77% early-onset). Early-onset psoriasis patients (EOPs) had a significantly higher frequency of severe disease and the Cw6*0602 allele. Carriers of rs1990760 T (946Thr) were more common in the EOPs (p < 0.001), and the effect was more pronounced among Cw6*0602-negatives. This variant was also associated with an increased risk of psoriatic arthritis (PsA) independent from other factors (OR = 1.62, 95%CI = 1.11–2.37). The rs3533754 and rs35744605 polymorphisms did not show significant differences between the two onset age or PsA groups. Compared to the controls, the 946Thr variant was more common in the EOPs (nonsignificant difference) and significantly less common in patients aged >40 years (p = 0.005). In conclusion, the common IFIH1 rs1990760 T allele was significantly more frequent in early-onset compared to late-onset patients. This variant was also an independent risk factor for PsA in our cohort. Our study reinforces the widely reported role of the IFIH1 gene variants on psoriatic disease. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Secukinumab is effective and safe in the long‐term treatment of plaque psoriasis in a daily practice setting: Multicenter study in 384 Spanish patients

Author

Chicharro, Pablo, primary, Llamas‐Velasco, Mar, additional, Armesto, Susana, additional, Herrera Acosta, Enrique, additional, Vidal, David, additional, Vilarrasa, Eva, additional, Rivera‐Diaz, Raquel, additional, De‐la‐Cueva, Pablo, additional, Martorell‐Calatayud, Antonio, additional, Ballescà, Ferran, additional, Belinchon, Isabel, additional, Carretero, Gregorio, additional, Rodriguez, Lourdes, additional, Romero‐Maté, Alberto, additional, Pujol‐Montcusí, Josep, additional, Salgado, Laura, additional, Sahuquillo‐Torralba, Antonio, additional, Coto‐Segura, Pablo, additional, Baniandrés Rodríguez, Ofelia, additional, Feltes, Rosa, additional, Riera‐Monroig, José, additional, and Dauden, Esteban, additional

Published
2022
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17. Secukinumab is effective in the treatment of recalcitrant palmoplantar psoriasis and palmoplantar pustular psoriasis in a daily practice setting

Author

Reolid, Alejandra, primary, Armesto, Susana, additional, Sahuquillo-Torralba, Antonio, additional, Torres, Tiago, additional, Feltes, Rosa, additional, Vilarrasa, Eva, additional, Belinchón, Isabel, additional, Cueva, Pablo de la, additional, Rodríguez, Lourdes, additional, Romero-Maté, Alberto, additional, Vidal, David, additional, Coto-Segura, Pablo, additional, Herrera-Acosta, Enrique, additional, Riera-Monroig, Josep, additional, Salgado, Laura, additional, Llamas-Velasco, Mar, additional, and Daudén, Esteban, additional

Published
2022
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18. High adherence to secukinumab in patients with moderate to severe psoriasis: a long‐term multicenter study in a daily practice setting

Author

Martos‐Cabrera, Luisa, primary, Llamas‐Velasco, Mar, additional, Armesto, Susana, additional, Herrera‐Acosta, Enrique, additional, Vidal, David, additional, Vilarrasa, Eva, additional, Rivera‐Diaz, Raquel, additional, de la Cueva, Pablo, additional, Martorell‐Calatayud, Antonio, additional, Ballescá, Ferran, additional, Belinchón, Isabel, additional, Carretero, Gregorio, additional, Rodríguez, Lourdes, additional, Romero‐Maté, Alberto, additional, Pujol‐Montcusí, J., additional, Salgado‐Boquete, Laura, additional, Sahuquillo‐Torralba, Antonio, additional, Coto‐Segura, Pablo, additional, Baniandrés, Ofelia, additional, Feltes, R., additional, Alsina, M., additional, and Daudén, Esteban, additional

Published
2022
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20. Fast and sustained improvement of patient‐reported outcomes in psoriatic patients treated with secukinumab in a daily practice setting

Author

Chicharro, Pablo, primary, Llamas‐Velasco, Mar, additional, Armesto, Susana, additional, Herrera‐Acosta, Enrique, additional, Vidal, David, additional, Vilarrasa, Eva, additional, Rivera, Raquel, additional, De la Cueva, Pablo, additional, Martorell‐Calatayud, Antonio, additional, Ballescà, Ferrán, additional, Belinchón, Isabel, additional, Carretero, Gregorio, additional, Rodríguez, Lourdes, additional, Romero‐Maté, Alberto, additional, Pujol‐Montcusí, Josep, additional, Salgado, Laura, additional, Sahuquillo‐Torralba, Antonio, additional, Coto‐Segura, Pablo, additional, Baniandrés‐Rodríguez, Ofelia, additional, Feltes, Rosa, additional, Alsina, Mercè, additional, and Daudén, Esteban, additional

Published
2022
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23. High adherence to secukinumab in patients with moderate to severe psoriasis: a long‐term multicenter study in a daily practice setting.

Author

Martos‐Cabrera, Luisa, Llamas‐Velasco, Mar, Armesto, Susana, Herrera‐Acosta, Enrique, Vidal, David, Vilarrasa, Eva, Rivera‐Diaz, Raquel, de la Cueva, Pablo, Martorell‐Calatayud, Antonio, Ballescá, Ferran, Belinchón, Isabel, Carretero, Gregorio, Rodríguez, Lourdes, Romero‐Maté, Alberto, Pujol‐Montcusí, J., Salgado‐Boquete, Laura, Sahuquillo‐Torralba, Antonio, Coto‐Segura, Pablo, Baniandrés, Ofelia, and Feltes, R.

Subjects
PATIENT compliance, PSORIASIS, PSORIATIC arthritis, PHOTOCHEMOTHERAPY, CLINICAL drug trials
Abstract

A. Sahuquillo-Torralba, Dr. P. Coto-Segura, Dr. O. Baniandrés, Dr. R. Feltes, and Dr. M. Alsina contributed to data collection, discussed the results, and commented on the manuscript. Dr. S. Armesto, Dr. E. Herrera-Acosta, Dr. D. Vidal, Dr. E. Vilarrasa, Dr. R. Rivera, Dr. P. de la Cueva, Dr. I. Belinchón, Dr. G. Carretero, Dr. L. Rodríguez, Dr. [Extracted from the article]

Published
2023
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37. Genome‐wide association analysis of psoriasis patients treated with anti‐TNF drugs

Author

Ovejero‐Benito, María C., primary, Muñoz‐Aceituno, Ester, additional, Sabador, David, additional, Almoguera, Berta, additional, Prieto‐Pérez, Rocío, additional, Hakonarson, Hakon, additional, Coto‐Segura, Pablo, additional, Carretero, Gregorio, additional, Reolid, Alejandra, additional, Llamas‐Velasco, Mar, additional, Abad‐Santos, Francisco, additional, and Daudén, Esteban, additional

Published
2020
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40. Potential Differences in the Cardiometabolic Risk Profile of Patients with Psoriatic Disease according to Their HLA-C∗06 Status.

Author

Queiro, Rubén, Coto-Segura, Pablo, Braña, Ignacio, Pino, Marina, and Burger, Stefanie

Subjects
*CARDIOVASCULAR diseases risk factors, *PSORIASIS, *BIOMARKERS, *HLA-B27 antigen, *SCIENTIFIC observation, *ACADEMIC medical centers, *CONFIDENCE intervals, *CROSS-sectional method, *MULTIVARIATE analysis, *WAIST circumference, *ODDS ratio
Abstract

The human leukocyte antigen-C ∗ 06 (HLA-C ∗ 06, formerly HLA-Cw6) is the main genetic biomarker in psoriatic disease. It has been related to several phenotypic traits in psoriatic disease, but its role in relation to cardiometabolic comorbidities is unknown at present. Here, we analyze the potential connections between this biomarker and the cardiometabolic profile of these patients. We carried out a cross-sectional observational study including 400 patients recruited at a single university hospital. Clinical and classical cardiometabolic factors were compared between HLA-C ∗ 06-positive and HLA-C ∗ 06-negative individuals (OR with 95% CI). Multivariate regression analyses were carried out to check for disease traits associated with different cardiometabolic risk factors. The study population included 215 men (53.8%) and 185 women (46.2%), mean age of 46 ± 15 years , and an average disease evolution of 17 ± 12.6 years. Ninety-three (23.3%) patients met CASPAR criteria for psoriatic arthritis. HLA-C ∗ 06 carriers (n : 160, 40%) showed an earlier age at disease onset, psoriasis family history, and more severe skin disease (type I disease). After correcting for age, sex, and disease duration, they also showed less hypertension (13.8% vs. 24.2%, OR 0.7 (95% CI: 0.42-0.78), p = 0.025), lower waist circumference (94.4 ± 13.7 vs. 98.3 ± 13.8 cm), and lower BMI (27 ± 4.4 vs. 28.1 ± 4.8 , p < 0.05). We confirmed the well-known association between HLA-C ∗ 06 and type I psoriatic disease. As a novel finding, patients carrying HLA-C ∗ 06 showed a better cardiometabolic profile. In any case, these findings need further confirmation. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Dermoscopy of Port-Wine Stains

Author

Vázquez-López, Francisco, Coto-Segura, Pablo, Fueyo-Casado, Alejandro, and Pérez-Oliva, Narciso

Published
2007

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