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1. Victimas del desplazamiento forzado: comorbilidad entre trastorno por estres postraumatico (TEPT) y depresivo mayor (TDM)/Post-traumatic Stress Disorder and Major Depressive Disorder in the context of displacement due to violence/Transtorno de estresse pos-traumatico e transtorno depressivo maior no contexto de deslocamento devido a violencia

Author

Torres Salazar, Yury Maciel, Mejía Jaimes, Lilibeth, Conde Cotes, Carlos Arturo, and Botelho de Oliveira, Silvia

Published
2021
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4. Estudio preliminar de la expresión proteómica cerebral de la región hipocampal de ratas expuestas a diferentes niveles de estrés inducido por el nado forzado Preliminary study of cerebral proteomics expression of hippocampal region from rats exposed to different stress levels induced by forced swimming

Author

Guerrero Nasser, Saez Rodrigo Torres, and Cotes Carlos Conde

Subjects
Estrés, hipocampo, proteómica, nado forzado, Stress, hippocampus, proteomic, forced swimming, Medicine
Abstract

Introducción: en general, los estímulos estresores pueden inducir respuestas adaptativas o mal adaptativas dependiendo, entre otras cosas, de su intensidad y la duración. Sin embargo, no se han llevado a cabo estudios que relacionen cuantitativa y cualitativamente la intensidad de estrés al que es expuesto un animal y la expresión de proteínas del hipocampo. Objetivo: evaluar la expresión diferencial de proteínas hipocampales en ratas Wistar-UIS, expuestas a diferentes niveles de estrés inducido por el nado forzado. Materiales y métodos: se utilizaron 30 ratas Wistar-UIS machos distribuidas aleatoriamente en 3 grupos según el tiempo de exposición al nado forzado como estímulo estresor (0, 5 y 15 minutos). Después de 24 horas se extrajeron los hipocampos dorsales y se realizó electroforesis bidimensional de las proteínas extraídas. A continuación, se llevó a cabo el procesamiento de las imágenes de los geles obtenidos utilizando el software PDQUEST 2D. Aquellas proteínas en las se detectaron intensidades asociadas a los tiempos de exposición al estímulo, se identificaron de manera presuntiva utilizando la base de datos bioinformática Export Protein Analysis System (EXPASY). Resultados: de acuerdo con el análisis proteómico y bioinformático se identificaron 60 proteínas, de las cuales, 38 eran comunes al hipocampo derecho e izquierdo; 13 del hipocampo derecho y 9 del izquierdo. Conclusión: se encontraron diferencias en la expresión de proteínas entre el hipocampo derecho e izquierdo del tipo dosis dependientes decrecientes después de haber sometido a los animales a diferentes niveles de estrés inducido por la prueba de nado forzado. Salud UIS 2012; 44 (1): 17-27Introduction: in general stressful stimuli can induce adaptive maladaptive responses, depending among other things, of their intensity and duration. However, no studies were found in the literature that link quantitatively and qualitatively the intensity of stress to which an animal is exposed, and hippocampal protein expression. Objective: to evaluate the differential hippocampal protein expression in Wistar-UIS rats, exposed to dissimilar levels of stress induced by forced swimming. Materials and methods: we used 30 rats randomly assigned to 3 groups according to duration of exposure to forced swimming as stressor stimulus (0, 5 and 15 minutes). 24 hours after the dorsal hippocampi were removed and two-dimensional electrophoresis was performed to the extracted proteins. Then, image processing of the gels obtained was performed using the PDQuest 2D software. Those proteins in which intensities were detected associated with the stimulus-exposure times were presumptively identified using Export Protein Analysis System (EXPASY) a bioinformatics database. Results: according to the bioinformatic and proteomic analyses we identified 60 proteins, 38 of which were common to both left and right hippocampi, 13 were found only in the right hippocampi and 9 in the left. Conclusion: dose-dependent decreasing rate differences in protein expression between the left and right hippocampus were found after animals were subjected to different levels of stress induced by forced swimming test. Salud UIS 2012; 44 (1): 17-27

Published
2012

5. Working memory in school-aged children: Exhibition intervals and distracters effects in Memonum computerized test/Memoria de trabajo en ninos escolarizados: efecto de intervalos de presentacion y distractores en la prueba computarizada Memonum/Memoria de trabalho em criancas em idade escolar: Efeitos de intervalos de apresentacao e distracao no teste computadorizado Memonum

Author

Vargas, Diana Karina Arguello, Duran, Karen Cristina Jacome, Garrido, Lia Margarita Martinez, Garzon, Gina Elizabeth Pineda, and Cotes, Carlos Arturo Conde

Published
2013

11. Víctimas del desplazamiento forzado: comorbilidad entre trastorno por estrés postraumático (TEPT) y depresivo mayor (TDM)

Author

Torres Salazar, Yury Maciel, Mejía Jaimes, Lilibeth, Conde Cotes, Carlos Arturo, Botelho de Oliveira, Silvia, Torres Salazar, Yury Maciel, Mejía Jaimes, Lilibeth, Conde Cotes, Carlos Arturo, and Botelho de Oliveira, Silvia

Abstract

The objective of this study was to identify comorbidity between PTSD and MDD in people who are victims of forced displacement and associated factors. A research with a quantitative approach, a nonexperimental cross-sectional design and a descriptive-analytical scope was carried out. 120 people, of both genders, from 18 to 57 years old, selected through a non-probabilistic convenience sampling, were evaluated. A structured clinical interview for Axis I diagnoses (SCID-I) was used based on the DSM IV criteria for PTSD and MDD, after the application of a questionnaire of sociodemographic data and clinical history with which the factors of risks and associated symptoms were registered. The prevalence for PTSD was 48%, 32% for MDD, and 21% for comorbidity, associated with suicidal ideation and attempt and rumination symptoms. The results were discussed in light of other prevalence studies and the importance of associated risk factors in understanding the comorbidity between PTSD and MDD., O objetivo deste estudo foi identificar a comorbidade entre TEPT e TDM em pessoas vítimas de deslocamento forçado e fatores associados. Realizou-se uma pesquisa com abordagem quantitativa, delineamento transversal não experimental e escopo analítico-descritivo. Foram avaliadas 120 pessoas, de ambos os sexos, com idade entre 18 e 57 anos, selecionadas por meio de amostra não probabilística de conveniência. A entrevista clínica estruturada para diagnósticos do Eixo I (SCID-I) foi utilizadacom base nos critérios do DSM IV para TEPT e TDM, após a aplicação de um questionário de dados sociodemográficos e história clínica com os fatores de riscos e sintomas associados. A prevalência de TEPT foi de 48%, 32% para TDM e 21% para comorbidade, associada a ideação suicida e sintomas de tentativa e ruminação. Os resultados foram discutidos à luz de outros estudos de prevalência e da importância dos fatores de risco associados no entendimento da comorbidade entre TEPT e TDM., El objetivo del presente estudio fue identificar comorbilidad entre TEPT y TDM en personas víctimas del desplazamiento forzado y factores asociados. Se realizó una investigación de enfoque cuantitativo, diseño no experimental de corte transversal y alcance descriptivo-analítico. Fueron evaluadas 120 personas, de ambos géneros, entre 18 a 57 años, seleccionadas a través de un muestreo no probabilístico por conveniencia. Se utilizó una entrevista clínica estructurada para diagnósticos del Eje I (SCID-I) basada en los criterios del DSM IV para el TEPT y TDM, posterior a la aplicación de un cuestionario de datos sociodemográficos y antecedentes clínicos con el que se registraron los factores de riesgos y síntomas asociados. La prevalencia para TEPT fue del 48%, para TDM del 32% y 21% para comorbilidad, asociada con ideación e intento suicida y síntoma de rumiación. Los resultados fueron discutidos a la luz de otros estudios de prevalencia y la importancia de los factores de riesgo asociados en la comprensión de la comorbilidad entre TEPT y TDM.

Published
2021

12. Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Author

Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Jr., Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Jr, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, III, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, and Fulmer, James

Published
2013
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17. Memória de trabalho em crianças em idade escolar: Efeitos de intervalos de apresentação e distração no teste computadorizado Memonum

Author

Argüello Vargas, Diana Karina, Jácome Durán, Karen Cristina, Martínez Garrido, Lía Margarita, Pineda Garzón, Gina Elizabeth, and Conde Cotes, Carlos

Subjects
lcsh:BF1-990, distração, exhibition intervals, intervalos de exposición, Memonum computerized test, child neuropsychology, working memory, BF1-990, intervalos de exposição, neuropsicologia infantil, lcsh:Psychology, distractor, Psychology, distracter, memoria de trabajo, neuropsicología infantil, teste computadorizado Memonum, memória de trabalho, prueba computarizada Memonum
Abstract

La presente investigación evaluó la memoria de trabajo visual a través de la prueba computarizada Memonum en niños escolarizados. Se evaluaron los efectos de tres tiempos de exposición (1, 4 y 8 segundos) y de la presentación de un distractor sobre el desempeño mnemónico en la prueba Memonum en 72 niños pertenecientes a un colegio del área metropolitana de Bucaramanga, Colombia, con edades entre 8 y 11 años de los grados tercero, cuarto y quinto de primaria. Se encontró una diferencia significativa entre los tiempos de exposición en las variables número de aciertos y aciertos acumulados, demostrando un mejor desempeño mnemónico en los participantes que presentaron la prueba en el tiempo de 8 segundos en comparación con los niños pertenecientes al grupo de 1 segundo; además, la presencia del distractor demostró una diferencia significativa en los aciertos y aciertos acumulados, considerándose como un estímulo generador de interferencia que perturba la capacidad de almacenamiento de la memoria de trabajo en niños. Adicionalmente, se halló una diferencia significativa en cuanto al uso de la estrategia de repetición mental, indicando que los participantes de los grupos de 4 y 8 segundos le asignaron mayor puntaje que los niños del grupo de 1 segundo. Un amplio tiempo de exposición de estímulos en la prueba Memonum aumenta la capacidad de retención; asimismo, el empleo de un distractor afecta en los participantes la capacidad de almacenamiento y esta, a su vez, aumenta de acuerdo a la progresión escolar, debido al uso de las estrategias mnemónicas que los niños utilizan para garantizar el recuerdo de las series numéricas Esta pesquisa avaliou a memória de trabalho visual através do teste computadorizado Memonum em crianças em idade escolar. Foram avaliados os efeitos de três tempos de exposição (1, 4 e 8 segundos) e da apresentação de uma distração sobre o desempenho no teste mnemônico Memonum em 72 crianças de uma escola da área metropolitana de Bucaramanga, Colombia com idades entre 8 e 11 anos de terceiro, quarto e quinto grau de ensino fundamental. Encontrou-se uma diferença significativa relacionada aos tempos de exposição nas variáveis número de acertos e acertos acumulados, demostrando um melhor desempenho mnemônico nos participantes que fizeram o teste no tempo de 8 segundos em comparação com as crianças do grupo de 1 segundo; adicionalmente, a presença da distração demonstrou uma diferença significativa nos acertos e acertos acumulados, considerando-se como um estímulo gerador de interferência que perturba a capacidade de armazenamento da memória de trabalho em crianças. Também, se encontrou uma diferença significativa no uso da estratégia de repetição mental, monstrando que os participantes dos grupos de 4 e 8 segundos atribuíram pontuações mais elevadas do que as crianças do grupo de 1 segundo. Um amplo tempo de exposição no teste Memonum incrementa a capacidade de retenção; igualmente, o uso de uma distração afeta nos participantes a capacidade de armazenamento e esta, por sua vez, aumenta de acordo com a progressão escolar, devido à utilização das estratégias mnemónicas que as crianças usam para garantir o recordo das séries numéricas. This study assessed visual working memory through Memonum computerized test in schoolchildren. The effects of three exposure times (1, 4 and 8 seconds) have been evaluated, and the presentation of a distractor on the mnemonic performance in the test Memonum in 72 children from a college in the metropolitan area of Bucaramanga, Colombia, aged between 8 and 11 in grades third, fourth and fifth grade. It has been found significant difference regarding the exposure time in the variables number of hits and successes accumulated, showing a better mnemonic performance in participants who took the test during 8 seconds compared to children who took the test during 1 second; in addition, the presence of a distractor showed a significant difference regarding the strengths and successes accumulated. Such distractor is considered a stimulus generator interference that disrupts the storage capacity of working memory in children. Additionally, a significant difference was found with respect to the use of mental rehearsal strategy, indicating that participants who took the test in 4 and 8 seconds, respectively, assigned higher scores than children who took the test in 1 second. A long exposure time to stimuli during Memonum test increases the holding capacity. Also, the use of a distractor affects the storage capacity and this, at the same time, increases the school progression due to the use of mnemonic strategies that children use to ensure the memory of the numerical series

Published
2013

18. MitraClip para el reparo de insuficiencia mitral severa

Author

Malkun, Celin, Fonseca, Jaime, Cotes, Carlos, Muñoz, Alfonso, and Benítez, Miguel

Subjects
Mitral dysfunction, Insuficiencia mitral, Cardiac insufficiency, Mitral insufficiency, Insuficiencia cardiaca, Disfunción mitral
Abstract

Resumen Objetivo: Reportar el primer caso de implante de MitraClip realizado en la costa atlántica. Material y métodos: Paciente femenina de 69 años de edad, con diagnóstico de: cardiopatía dilatada de 10 años de evolución con aumento progresivo de deterioro funcional. Ha presentado edema pulmonar recidivante. Resultados: Se realiza procedimiento de implante del dispositivo. Mediante cateterismo transeptal, se procede a introducir el MitraClip con maniobras del sistema de posicionamiento pasando la válvula mitral guiado por el ETE 3 D y se realiza la captura de ambos bordes de la válvula en el sitio de mayor regurgitación A2/P2 sujetando los bordes por él. Se observa persistencia de la insuficiencia moderada por lo que se coloca un segundo MitraClip en forma satisfactoria. Se realizan las medicines Doppler observando una insuficiencia residual mínima. Se corrobora por la angiografía y el ETE su adecuada implantación. Se considera un éxito pudiendo realizar el implante del dispositivo en forma rápida, adecuada y sin complicaciones. Conclusiones: Se reporta el primer caso de implante de MitraClip para el manejo de la IM severa, en la ciudad de Barranquilla, siendo la segunda ciudad de Colombia, después de Cali, donde se implanta este tipo de dispositivos para el reparo de la insuficiencia mitral severa. Abstract Objective: To report the first case if MitraClip implantation performed in the Atlantic coast. Material and methods: 69 year-old female patient diagnosed with dilated cardiomyopathy with a 10-year course suffering from gradual functional deterioration. She developed relapsing pulmonary edema. Results: Device implantation is performed. By means of a transseptal catheterization MitraClip is inserted with positioning system operations below the mitral valve guided by 3 D TEE and captures both vale leaflets on the place where most A2/P2 regurgitation is located, thus holding the leaflets. Mild insufficiency is still observed, so a second MitraClip is implanted succesfully. Doppler measurements reveal minimal residual insufficiency. Angiography and TEE confirm correct implantation. Procedure is considered a success, being able to conduct device implantation in a fast, proper and uncomplicated way. Conclusions: The first case of MitraClip implant for management of severe MI in Barranquilla is presented, this being the second Colombian city after Cali where this type of device is implanted for the repair of severe mitral insufficiency

Published
2016

21. Evaluation of Autonomic Displays Associated to the Application of an Auditory-Visual Emotional Memory Test in Humans

Author

Conde Cotes, Carlos Arturo, Prada Sarmiento, Edward Leonel, Martínez Garrido, Lia Margarita, Botelho de Oliveira, Silvia, and Becerra Tomaz, Carlos Alberto

Subjects
Nervous system, historias, emociones, conductance skin level, frequency of pulse, autonomic, sistema nervioso autónomo, autonomic nervous system, Emotions, lcsh:BF1-990, stories, emotions, physiological manifestations, frecuencia de pulso, manifestaciones fisiológicas, Neurobehavioral Manifestations, conductancia de la piel, lcsh:Psychology, Memory, manifestaciones neurocomportamentales, Memoria, neurobehavioral Manifestations, Nervous System Autonomic
Abstract

Con el fin de contribuir a la caracterización fisiológica del estado de alertamiento de personas expuestas a una prueba de memoria emocional auditivo-visual, se estudiaron 63 voluntarios, entre 18 y 48 años de edad, distribuidos aleatoriamente en dos grupos de acuerdo con las versiones narradas de las historias de la prueba (emocional o neutra). Se evaluó el desempeño mnemónico, la atribución del valor emocional y se registraron, en paralelo a las sesiones, la conductancia eléctrica de la piel (SCL) y la frecuencia de pulso (FP). En conjunto, los resultados verificaron el efecto de potenciación mnemónica inducida por la versión emocional asociada a activación simpática e inhibición parasimpática, tanto en adquisición como en evocación. Por lo tanto, se concluye que la percepción de alertamiento es coherente con el cuadro fisiológico inducido. In order to contribute to the characterization of people's arousal state when exposed to an audio-visual emotional memory test, 63 volunteers aged from 18 up to 48 years old were distributed randomly in two groups according to the test stories' narrated versions (Emotional or Neutral). The mnemonic performance, the emotional value, and in parallel to the sessions, the skin's electrical conductance (SCL) and pulse's frequency (FP) were evaluated. Altogether, these results verified an enhancer mnemonic effect induced by the emotional version associated to sympathetic activation and parasympathetic inhibition both in acquisition and recovery. It is therefore concluded that the arousal perception is coherent with the induced physiological state.

Published
2008

23. Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Author

Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, Fulmer, James, Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, and Fulmer, James

Abstract

Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.0

Published
2017

25. Los Mapas Conceptuales como Estrategia que Permite Mejorar el Proceso de Enseñanza Aprendizaje de la Neuroanatomía

Author

Flórez-Uribe,Adriana Margarita, Ayala-Pimentel,Jaime Otoniel, and Conde Cotes,Carlos Arturo

Subjects
Mapa conceptual, Aprendizaje significativo, Neuroanatomía
Abstract

Los mapas conceptuales son una estrategia de enseñanza aprendizaje que permite organizar los contenidos de una temática determinada facilitando su interpretación, comprensión y análisis. Su construcción en forma grupal incrementa la capacidad de los estudiantes de aprender de modo significativo debido al aumento del interés y la atención para integrar los conceptos más relevantes en forma cooperativa. El objetivo de este trabajo fue evaluar el rendimiento académico de los estudiantes que cursaron la asignatura morfofisiología II en la Universidad Industrial de Santander (UIS) al implementar el uso de los mapas conceptuales como herramienta pedagógica para la enseñanza de la anatomía funcional del sistema nervioso. Se realizó un estudio de tipo prospectivo analítico con mediciones transversales en cuatro momentos en 130 estudiantes de medicina (II semestre 2006) que cursaban la asignatura morfofisiología II a quienes durante los dos primeros cortes se les transmitió la información en forma de cátedra magistral y para el tercer corte se dividieron en grupos de trabajo que utilizaron como método activo de enseñanza los mapas conceptuales. Los resultados de sus exámenes académicos escritos se compararon utilizando la prueba de Bonferroni (p

Published
2011

26. Efectos a largo plazo de los síntomas depresivos en una tarea de memoria de trabajo con y sin interferencia atencional

Author

Botelho de Oliveira, Silvia, Jaimes Alvarado, Laura Fernanda, Conde Cotes, Carlos Arturo, Botelho de Oliveira, Silvia, Jaimes Alvarado, Laura Fernanda, and Conde Cotes, Carlos Arturo

Abstract

La neurobiología de la depresión involucra cambios estructurales del sistema nervioso relacionados con procesos cognitivos como la memoria y la atención. El objetivo del presente estudio fue evaluar el efecto a largo plazo de la sintomatología depresiva (SD) en una tarea de memoria de trabajo visual con y sin interferencia atencional en estudiantes universitarios. Se utilizó un diseño factorial de 2 × 2 en el cual las variables independientes fueron la condición clínica (con SD y sin SD) y la versión del Memonum (con o sin interferencia de color). Memonum es un software para evaluar memoria de trabajo por medio de la retención de dígitos directos, en dos versiones: una blanco-negro (sin interferencia) y otra con un distractor atencional de color (con interferencia). Para la evaluación de la SD, 76 universitarios respondieron al CES-D, luego se les aplicó aleatoriamente una u otra versión de la prueba Memonum (con o sin interferencia de color), 2 semanas después de la detección de síntomas. De manera general, la SD no alteró a largo plazo el desempeño de los participantes en tareas de memoria de trabajo visual con o sin interferencia atencional. Sin embargo, se pudo establecer que la utilización de las estrategias para la ejecución de la tarea mnemónica dependió de la condición clínica, y la agrupación fue la menos usada por los participantes con SD., The neurobiology of depression involves structural changes in the nervous system associated with cognitive processes such as memory and attention. This study sought to evaluate the long-term effect of depressive symptomatology (DS) using a task of visual working memory with or without attentional interference in college students. A 2 × 2 factorial design was used wherein the independent variables were the clinical condition (with and without DS) and the Memonum version (with and without interference of color). The Memonum consists of software to evaluate working memory through retention of direct digits, in two versions: a black-white (without interference) and another with a color attentional distractor (with interference). Depressive symptomatology was evaluated by applying the CES-D to 76 undergraduates. Two week after the diagnosis of DS, the test version was randomly applied (with or without attentional interference). The DS did not alter long-term performance of the tasks involved in visual working memory with or without attentional interference. However, it was found that the use of strategies for mnemonic task performance depended on the clinical condition, being the strategy of grouping the least used by the participants with DS.

Published
2015

27. Implementación de una prueba automatizada para la evaluación de memoria operacional: Memonum

Author

Albarracín Rodríguez, Ángela Pilar, Dallos Arenales, Marta Isabel, and Conde Cotes, Carlos Arturo

Subjects
memory, memoria, mental processes, procesos mentales, response time, tiempo de reacción
Abstract

Introducción: Memonum es un test computarizado que se basa en la tarea de retención de dígitos directos de Wechsler. El estudio evaluó en una población universitaria la infl uencia de diversos intervalos de presentación de dígitos e interferencia atencional sobre el desempeño mnemónico derivado de la prueba Memonum. Método: La muestra estuvo conformada por 28 estudiantes, entre los 17 y los 25 años de edad, a quienes se les aplicó el Memonum en sus dos presentaciones (blanco-negro sin interferencia atencional y color con interferencia) con intervalos de exposición de 1, 8 y 16 segundos. Al fi nalizar cada intervalo se aplicó un formato de autoinforme para evaluar las estrategias empleadas y el grado de distracción y difi cultad generado por la prueba. Resultados: El número de aciertos alcanzado por los participantes en la prueba Memonum fue similar al reportado con la subprueba de Wechsler. Además, el incremento de los intervalos de exposición de los dígitos en la prueba Memonum aumentó el desempeño mnemónico de los individuos. La presentación en color tuvo un efecto de interferencia atencional detectado por los análisis de variabilidad en el dominio del tiempo. Conclusión: La prueba Memonum es una herramienta útil en la evaluación de la memoria operacional por medio visual, pues detecta la perturbación atencional y se plantea como una prueba viable de evaluación y diagnóstico. Introduction: The Memonum test is a computerized test based on the Wechsler test for retention of direct digits. The present study evaluated the infl uence of different intervals of digits presentation and attention interference on the mnemonic performance derived from the Memonum test, in a university population. Method: Twenty-eight students between the ages of 17 and 25 years were tested. All the subjects were tested with the Memonum in two presentations (Black-White without attention interference, and Color with interference), with exhibition intervals of 1, 8 and 16 seconds. After each interval an auto-test format was applied to evaluate the used strategies, and the level of distraction and diffi culty generated by the test. Results: The number of successes obtained by the participants in the Memonum test was similar to that reported with the Wechsler sub-test. In addition, the increase of the exhibition intervals of the digits in the Memonum test, increased the mnemonic performance of the subject. The Color presentation had an interference effect at the attention level detected by the analyses of variability in the time dominion. Conclusion: The Memonum test is a useful tool in the evaluation of working memory as a visual test, that detects disturbances at the attention level, rendering a viable test for evaluation and diagnosis.

Published
2008

28. Memoria de trabajo en niños escolarizados efecto de intervalos de presentación y distractores en la prueba computarizada Memonum

Author

Argüello Vargas, Diana Karina, Martínez Garrido, Lía Margarita, Pineda Garzón, Gina Elizabeth, Jácome Durán, Karen Cristina, Conde Cotes, Carlos Arturo, Argüello Vargas, Diana Karina, Martínez Garrido, Lía Margarita, Pineda Garzón, Gina Elizabeth, Jácome Durán, Karen Cristina, and Conde Cotes, Carlos Arturo

Abstract

Esta pesquisa avaliou a memória de trabalho visual através do teste computadorizado Memonum em crianças em idade escolar. Foram avaliados os efeitos de três tempos de exposição (1, 4 e 8 segundos) e da apresentação de uma distração sobre o desempenho no teste mnemônico Memonum em 72 crianças de uma escola da área metropolitana de Bucaramanga, Colombia com idades entre 8 e 11 anos de terceiro, quarto e quinto grau de ensino fundamental. Encontrou-se uma diferença significativa relacionada aos tempos de exposição nas variáveis número de acertos e acertos acumulados, demostrando um melhor desempenho mnemônico nos participantes que fizeram o teste no tempo de 8 segundos em comparação com as crianças do grupo de 1 segundo; adicionalmente, a presença da distração demonstrou uma diferença significativa nos acertos e acertos acumulados, considerando-se como um estímulo gerador de interferência que perturba a capacidade de armazenamento da memória de trabalho em crianças. Também, se encontrou uma diferença significativa no uso da estratégia de repetição mental, monstrando que os participantes dos grupos de 4 e 8 segundos atribuíram pontuações mais elevadas do que as crianças do grupo de 1 segundo. Um amplo tempo de exposição no teste Memonum incrementa a capacidade de retenção; igualmente, o uso de uma distração afeta nos participantes a capacidade de armazenamento e esta, por sua vez, aumenta de acordo com a progressão escolar, devido à utilização das estratégias mnemónicas que as crianças usam para garantir o recordo das séries numéricas., La presente investigación evaluó la memoria de trabajo visual a través de la prueba computarizada Memonum en niños escolarizados. Se evaluaron los efectos de tres tiempos de exposición (1, 4 y 8 segundos) y de la presentación de un distractor sobre el desempeño mnemónico en la prueba Memonum en 72 niños pertenecientes a un colegio del área metropolitana de Bucaramanga, Colombia, con edades entre 8 y 11 años de los grados tercero, cuarto y quinto de primaria. Se encontró una diferencia significativa entre los tiempos de exposición en las variables número de aciertos y aciertos acumulados, demostrando un mejor desempeño mnemónico en los participantes que presentaron la prueba en el tiempo de 8 segundos en comparación con los niños pertenecientes al grupo de 1 segundo; además, la presencia del distractor demostró una diferencia significativa en los aciertos y aciertos acumulados, considerándose como un estímulo generador de interferencia que perturba la capacidad de almacenamiento de la memoria de trabajo en niños. Adicionalmente, se halló una diferencia significativa en cuanto al uso de la estrategia de repetición mental, indicando que los participantes de los grupos de 4 y 8 segundos le asignaron mayor puntaje que los niños del grupo de 1 segundo. Un amplio tiempo de exposición de estímulos en la prueba Memonum aumenta la capacidad de retención; asimismo, el empleo de un distractor afecta en los participantes la capacidad de almacenamiento y esta, a su vez, aumenta de acuerdo a la progresión escolar, debido al uso de las estrategias mnemónicas que los niños utilizan para garantizar el recuerdo de las series numéricas., This study assessed visual working memory through Memonum computerized test in schoolchildren. The effects of three exposure times (1, 4 and 8 seconds) have been evaluated, and the presentation of a distractor on the mnemonic performance in the test Memonum in 72 children from a college in the metropolitan area of Bucaramanga, Colombia, aged between 8 and 11 in grades third, fourth and fifth grade. It has been found significant difference regarding the exposure time in the variables number of hits and successes accumulated, showing a better mnemonic performance in participants who took the test during 8 seconds compared to children who took the test during 1 second; in addition, the presence of a distractor showed a significant difference regarding the strengths and successes accumulated. Such distractor is considered a stimulus generator interference that disrupts the storage capacity of working memory in children. Additionally, a significant difference was found with respect to the use of mental rehearsal strategy, indicating that participants who took the test in 4 and 8 seconds, respectively, assigned higher scores than children who took the test in 1 second. A long exposure time to stimuli during Memonum test increases the holding capacity. Also, the use of a distractor affects the storage capacity and this, at the same time, increases the school progression due to the use of mnemonic strategies that children use to ensure the memory of the numerical series.

Published
2013

31. Análisis comportamental de ratas expuestas al laberinto en cruz elevado bajo dos horarios de alimentación

Author

Conde Cotes, Carlos, Nieto, Javier, Orozco Vargas, Luis Carlos, Conde Cotes, Carlos, Nieto, Javier, and Orozco Vargas, Luis Carlos

Abstract

Introduction: Considering that the elevated plus maze (EPM) for rodents is, actually, the anxiety model more used in the world, and that, the rat behavior in this model is much vulnerable to multiple variables, the current work studied the behavioral effects of two feeding schedules on rat behavior (males and females), evaluating the variables discrimination capacity and possible confusion variables. Materials and methods: Were evaluated 31 animals of both genders and the same age. Since 21 post-natal day, one group per gender received food during the morning and another group, during the afternoon. The animals were individually exposed to the EPM during 5 minutes between 8 and 12 in the morning. The sessions, were filmed and processed using software designed for that objective. Results:It was find that the animals feeding in the same schedule of the experiments, presented higher exploratory activity associated to the enclosed arms and to the center of the EPM. The time spent on this places, would be the variables with the best sensitivity and specificity to recognize these effects. It does not discard the effect on the permanence time in the open arms. Conclusions and recommendations: The feeding schedule, influence significantly the rat behavior in the EPM, for that reason, it is recommended to consider this aspect in the experiments for anxiety studies., Introducción: Considerando que el laberinto en cruz elevado (LCE) para roedores es en la actualidad el modelo de ansiedad mas ampliamente utilizado en el mundo entero y que el comportamiento de la rata en este modelo es altamente vulnerable a múltiples variables, el presente trabajo estudió los efectos de dos esquemas de alimentación sobre el comportamiento de ratas machos y hembras, estimando la capacidad de discriminación de variables y posibles variables de confusión. Materiales y métodos: Se evaluaron 31 animales de ambos géneros y de la misma edad. Desde el día 21 post-natal, un grupo de cada género recibió alimento cotidiano por la mañana y otro grupo durante la tarde. Los animales fueron expuestos individualmente al LCE durante 5 minutos entre las 8 y las 12 de la mañana. Las sesiones fueron filmadas y procesadas con ayuda de un software diseñado para ese fin. Resultados: Se encontró que los animales alimentados en el mismo horario de los experimentos, presentaron mayor actividad exploratoria asociada a los brazos cerrados y al centro del LCE. El tiempo de permanencia en estos lugares podrían ser las variables de mejor sensibilidad y especificidad para reconocer tales efectos. No se descartó el efecto sobre los tiempos de permanencia en los brazos abiertos. Conclusiones y recomendaciones: El horario de alimentación influye de manera significativa sobre el comportamiento de las ratas en el LCE, por tal motivo se recomienda considerar estos aspectos en los experimentos dirigidos al estudio de la ansiedad.

Published
2008

35. Modelos Animales de EstrésPost-traumático

Author

Botelho de Oliveira, Silvia, Conde Cotes, Carlos, Botelho de Oliveira, Silvia, and Conde Cotes, Carlos

Abstract

The current article describes the general and peculiar foundations of several animal models of the Post-traumatic StressDisorder (PTSD). It describes examples of models that use the conditional fear, the startle potentialized by fear, the learnedhelplessness, the sensitization and the hipocampal degeneration. Additionally, the criterion of Yehuda and collaborators aredescribed and in their context, the authors sketch the proposal of the elevated plus maze with its phenomenon known as “Onetrial tolerance” as a possible model of the PTSD., El presente artículo describe los fundamentos generales y particulares de diversos modelos animales del trastorno de estrés post-traumático (TEPT). Describe ejemplos de modelos que utilizan el miedo condicionado, el sobresalto potenciado por miedo, ladesesperanza aprendida, la sensibilización y la degeneración hipocampal. Adicionalmente, se describen los criterios de Yehuda ycolaboradores y en su contexto, los autores esbozan la propuesta del laberinto en cruz elevado con su fenómeno conocido como“One trial Tolerante” como un posible modelo del TEPT.

Published
2003

36. Efecto del Período de Manipulación-Exposición y la Resocialización Sobre la Actividad Exploratoria y la Memoria de Ratas Expuestas al Campo Abierto

Author

Uribe Valencia, Carlos Enrique, Velasquez Martínez, María Carolina, Conde Cotes, Carlos, Uribe Valencia, Carlos Enrique, Velasquez Martínez, María Carolina, and Conde Cotes, Carlos

Abstract

The pharmacological effects over behavioral evaluation in open field (OF) protocol, evolve diferents intervals of time between the drug aplication and the exposure of the animal to the open field (A-E inetrval), Previous observations in our laboratory, had suggested that the handling protocol, 5 or 30 minutes before the behavioral evaluation, could produce independent effects of the drug. The observations also had suggested that the interval between housing in the cage and the experimental day, could modify the exploratory activity, This work asses diferents A-E intervals (0, 5 and 30 minutes) on the exploratory activity in the OF. Aditionally, was evaluated the exploratory activity, of two animal groups housing in cages, 4 weeks or 48 hours before the animal exposition to the OF. On a second animal exposition to the OF (72 hours later) was evaluated the mnemonic effects related to these treatments. The results shown that: A) Handling rat, close to a behavioral session (5 or 30 min) in the OF, induce long term changes of the general exploratory activity B) Animal re-socialitation 48 hours before the behavioral evaluation in the OF, decrease the general exploratory activity of the rat in the two sessions. C) Was proved the preference for the enclosed place, and an aversivity gradient associated to the different places into the OF. Based in these results, we recomend that that expertments to test drugs including exploratory activity, must take in count these intervals to discusse their results., La evaluación comportamental del efecto farmacológico en protocolos como el campo abierto (CA) implica diferentes intervalos de tiempo entre la aplicación del fármaco y la exposición del animal a dicho campo (Intervalo M-E). En observaciones previas en nuestro laboratorio, se había sugerido que la sola manipulación 5 o 30 minutos antes de la evaluación comportamental, podría tener un efecto independiente del fármaco. Las observaciones también habían sugerido que el intervalo de tiempo entre el agrupamiento en sus jaulas y el día del experimento afectaba la actividad exploratoria. El presente trabajo exploró los efectos de diferentes intervalos M-E (0,5 y 30 minutos) sobre la actividad exploratoria en el CA. Adicionalmente, se evaluó la actividad exploratoria de dos grupos de animales alojados en sus jaulas 4 semanas o 48 horas antes de la exposición al CA (re-socializados). En una segunda exposición de los animales al CA se evaluaron los efectos mnemónicos atribuibles a dichos tratamientos. Los resultados mostraron que: A) La manipulación realizada por el experimentador, cercana a una sesión de análisis comportamental (5 y 30 minutos) en un CA, induce cambios a largo plazo sobre la actividad exploratoria general. B) La re-socialización dada 48 horas antes de la evaluación comportamental en el CA, disminuye la actividad exploratoria general en las dos sesiones de la rata en dicho campo. C) Se comprobó la preferencia de 5a rata por los lugares protegidos a la vez que se verificó un gradiente de aversividad por zonas del CA. Basado en estos resultados, se recomienda que bioensayos para evaluar fármacos que incluyan medición de actividad exploratoria deben tener en cuenta estos intervalos para !a discusión de sus resultados.

Published
2002

37. Efecto De La Presión Inhibitoria Sobre El Músculo Espástico

Author

Herrera Ordóñez, Carlos Gabriel, Velasquez Martínez, María Carolina, Rincón Castillo, Emerson Julián, Santos Ardila, Gustavo Adolfo, Conde Cotes, Carlos, Herrera Ordóñez, Carlos Gabriel, Velasquez Martínez, María Carolina, Rincón Castillo, Emerson Julián, Santos Ardila, Gustavo Adolfo, and Conde Cotes, Carlos

Abstract

The purpose of this review is to contribute to the systematizing of knowledge about the technique of the Inhibitory Pressure (IP), its application methods and effects on the spastic muscle, based on the analysis of the results obtained in several experimental studies. Additionally, some neurophysiologic mechanisms are reviewed associated to the obtained responses from the application of the IP. Three protocols of this technique are described: continuous pressure (with diverse magnitudes), intermittent pressure and circumferential pressure, with their respective electrophysiological results. After the revision it is concluded that the protocol of continuous pressure offers the best results of muscular relaxation but, in al) the cases, this effect is present during very short time. It is recommended to take account of the mechanisms and the analysis of different results that here have been discussed to establish appropriate application approaches to use the IP and to be able to estimate the therapeutic effects., El propósito de esta revisión es contribuirá la sistematización de conocimientos acerca de la técnica de la Presión Inhibitoria (PI), sus métodos de aplicación y efectos sobre el músculo espástico, con base en el análisis de los resultados obtenidos en diversos estudios experimentales, Adicionalmente se revisan algunos mecanismos neurofisiológicos implicados en las respuestas obtenidas de la aplicación de la PI. Se describen 3 protocolos de aplicación de esta técnica: Presión continua (con diversas magnitudes), presión intermitente y presión circunferencial, con sus respectivos resultados electrofisiológicos. Después de la revisión se concluye que el protocolo depresión continua ofrece los mejores resultados de relajación muscular pero en todos los casos, dicho efecto es a muy corto plazo. Se recomienda tomar en consideración los mecanismos y el análisis de los diferentes resultados aquí discutidos para el establecimiento de adecuados criterios de la aplicación de la PI y para poder estimar los efectos terapéuticos.

Published
2002

39. N‐terminal probrain natriuretic peptide (NT‐proBNP) in the emergency diagnosis and in‐hospital monitoring of patients with dyspnoea and ventricular dysfunction

Author

Bayés‐Genís, Antoni, primary, Santaló‐Bel, Miquel, additional, Zapico‐Muñiz, Edgar, additional, López, Laura, additional, Cotes, Carlos, additional, Bellido, Jesús, additional, Leta, Rubén, additional, Casan, Pere, additional, and Ordóñez‐Llanos, Jordi, additional

Published
2004
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40. Memoria de trabajo en niños escolarizados: fecto de intervalos de presentación y distractores en la prueba computarizada Memonum.

Author

Argüello Vargas, Diana Karina, Jácome Durán, Karen Cristina, Martínez Garrido, Lía Margarita, Pineda Garzón, Gina Elizabeth, and Conde Cotes, Carlos Arturo

Subjects
SHORT-term memory, SCHOOL-age child care, MNEMONICS, ACHIEVEMENT gains (Education)
Abstract

Copyright of Avances en PsicologÍa Latinoamericana is the property of Colegio Mayor de Nuestra Senora del Rosario and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2013

41. Aportes fisiológicos a la validez de criterio y constructo del diagnóstico de ansiedad según entrevista psiquiátrica y el State-Trait Anxiety Inventory (STAI) en una muestra de estudiantes universitarios colombianos.

Author

Cotes, Carlos Arturo Conde, Vargas, Luis Carlos Orozco, Rangel, Ana Mireya Báez, and Arenales, Marta Isabel Dallos

Subjects
ANXIETY disorders, PSYCHOLOGICAL stress, NURSING students, MENTAL health services, PERSONALITY, DIAGNOSIS, MENTAL depression, SOCIAL anxiety
Abstract

Copyright of Revista Colombiana de Psiquiatria is the property of Asociacion Colombiana de Psiquiatria and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2009

42. Evaluación de las manifestaciones autonómicas asociadas a la aplicación de una prueba auditivovisual de memoria emocional en humanos.

Author

Arturo Conde Cotes, Carlos, Leonel Prada Sarmiento, Edward, Margarita Martínez Garrido, Lía, Botelho De Oliveira, Silvia, and Alberto Becerra Tomaz, Carlos

Subjects
*EMOTIONAL intelligence, *EMOTIONS, *MEMORY research, *MNEMONICS, *AUTONOMIC nervous system, *AUDIOVISUAL materials
Abstract

In order to contribute to the characterization of people's arousal state when exposed to an audio-visual emotional memory test, 63 volunteers aged from 18 up to 48 years old were distributed randomly in two groups according to the test stories' narrated versions (Emotional or Neutral). The mnemonic performance, the emotional value, and in parallel to the sessions, the skin's electrical conductance (SCL) and pulse's frequency (FP) were evaluated. Altogether, these results verified an enhancer mnemonic effect induced by the emotional version associated to sympathetic activation and parasympathetic inhibition both in acquisition and recovery. It is therefore concluded that the arousal perception is coherent with the induced physiological state. [ABSTRACT FROM AUTHOR]

Published
2008

43. Resultados inmediatos y a largo plazo de la angioplastia con stentdel tronco común

Author

Martí, Vicens, Planas, Francesc, Cotes, Carlos, García, Joan., Guiteras, Pere., López, Laura, and Augé, Josep M.

Abstract

La cirugía de derivación aortocoronaria ha sido considerada el tratamiento de elección de la estenosis del tronco común. Diversos estudios multicéntricos sugieren la posibilidad de la angioplastia con stent. El objetivo del presente estudio fue analizar los resultados inmediatos y a largo plazo de la angioplastia con stent en el tronco común, así como identificar los factores predictores de mortalidad.

Published
2004
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44. Evaluación de las manifestaciones autonómicas asociadas a la aplicación de una prueba auditivo-visual de memoria emocional en humanos

Author

Conde Cotes, Carlos Arturo; Universidad Industrial de Santander, Prada Sarmiento, Edward Leonel; Universidad Pontificia Bolivariana, Martínez Garrido, Lía Margarita; Universidad Pontificia Bolivariana, Botelho de Oliveira, Silvia; Universidad de Brasilia, Becerra Tomaz, Carlos Alberto; Universidad de Brasilia, Conde Cotes, Carlos Arturo; Universidad Industrial de Santander, Prada Sarmiento, Edward Leonel; Universidad Pontificia Bolivariana, Martínez Garrido, Lía Margarita; Universidad Pontificia Bolivariana, Botelho de Oliveira, Silvia; Universidad de Brasilia, and Becerra Tomaz, Carlos Alberto; Universidad de Brasilia

Abstract

Con el fin de contribuir a la caracterización fisiológica del estado de alertamiento de personas expuestas a una prueba de memoria emocional auditivo-visual, se estudiaron 63 voluntarios, entre 18 y 48 años de edad, distribuidos aleatoriamente en dos grupos de acuerdo con las versiones narradas de las historias de la prueba (emocional o neutra). Se evaluó el desempeño mnemónico, la atribución del valor emocional y se registraron, en paralelo a las sesiones, la conductancia eléctrica de la piel (SCL) y la frecuencia de pulso (FP). En conjunto, los resultados verificaron el efecto de potenciación mnemónica inducida por la versión emocional asociada a activación simpática e inhibición parasimpática, tanto en adquisición como en evocación. Por lo tanto, se concluye que la percepción de alertamiento es coherente con el cuadro fisiológico inducido.

45. Prueba Computarizada Memonum: Efecto de Intervalos y Distractores sobre la Memoria de Trabajo en Mujeres Mayores de 50 Años.

Author

Prada Sarmiento, Edward Leonel; Universidad Pontificia Bolivariana, Pineda Garzón, Gina Elizabeth; Universidad Industrial de Santander, Mejía Orduz, Manuel Alejandro; Universidad Industrial de Santander, Conde Cotes, Carlos Arturo; Universidad Industrial de Santander, Prada Sarmiento, Edward Leonel; Universidad Pontificia Bolivariana, Pineda Garzón, Gina Elizabeth; Universidad Industrial de Santander, Mejía Orduz, Manuel Alejandro; Universidad Industrial de Santander, and Conde Cotes, Carlos Arturo; Universidad Industrial de Santander

Abstract

Mediante la prueba computarizada Memonum se evaluaron los efectos de dos intervalos de exposición de dígitos (1 y 8 segundos), y la presentación de un distractor sobre el desempeño de la memoria de trabajo en 80 mujeres mayores de 50 años. Se evidenció un efecto significativo del intervalo sobre las variables: número de aciertos, aciertos acumulados, y empleo de estrategias adicionales, demostrando un mejor desempeño mnemónico en participantes que presentaron la prueba en el intervalo de 8 segundos y sugiriendo que un tiempo amplio de exposición potencia la capacidad de almacenamiento de la memoria en adultos mayores. La presencia del distractor tuvo un efecto significativo sobre el número de aciertos acumulados, considerándose como un estimulo interferente capaz de afectar la memoria de trabajo en adultos mayores.

46. Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial

Author

Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, Fulmer, James, Maggioni, Aldo P., Greene, Stephen J., Fonarow, Gregg C., Böhm, Michael, Zannad, Faiez, Solomon, Scott D., Lewis, Eldrin F., Baschiera, Fabio, Hua, Tsushung A., Gimpelewicz, Claudio R., Lesogor, Anastasia, Gheorghiade, Mihai, Ramos, Silvina, Luna, Alejandra, Miriuka, Santiago, Diez, Mirta, Perna, Eduardo, Luquez, Hugo, Pinna, Jorge Garcia, Castagnino, Jorge, Alvarenga, Pablo, Ibañez, Julio, Blumberg, Eduardo Salmon, Dizeo, Claudio, Guerrero, Rodolfo Ahuad, Schygiel, Pablo, Milesi, Rodolfo, Sosa, Carlos, Hominal, Miguel, Marquez, Lilia Lobo, Poy, Carlos, Hasbani, Eduardo, Vico, Marisa, Fernandez, Alberto, Vita, Nestor, Vanhaecke, Johan, De Keulenaer, Gilles, Striekwold, Harry, Vervoort, Geert, Vrolix, Mathias, Henry, Philippe, Dendale, Paul, Smolders, Walter, Marechal, Patrick, Vandekerckhove, Hans, Oliveira, Mucio, Neuenschwande, Fernando, Reis, Gilmar, Saraiva, Jose, Bodanese, Luiz, Canesin, Manoel, Greco, Oswaldo, Bassan, Roberto, Marino, Roberto Luis, Giannetti, Nadia, Moe, Gordon, Sussex, Bruce, Sheppard, Richard, Huynh, Thao, Stewart, Robert, Haddad, Haissam, Echeverria, Luis, Quintero, Adalberto, Torres, Adriana, Jaramillo, Mónica, Lopez, Mónica, Mendoza, Fernan, Florez, Noel, Cotes, Carlos, Garcia, Magali, Belohlavek, Jan, Hradec, Jaromir, Peterka, Martin, Gregor, Pavel, Monhart, Zdenek, Jansky, Petr, Kettner, Jiri, Reichert, Petr, Spinar, Jindrich, Brabec, Tomas, Hutyra, Martin, Solar, Miroslav, Pietilä, Mikko, Nyman, Kai, Pajari, Risto, Cohen, Ariel, Galinier, Michel, Gosse, Philippe, Livarek, Bernard, Neuder, Yannick, Jourdain, Patrick, Picard, François, Isnard, Richard, Hoppe, Uta, Kaeaeb, Stefan, Rosocha, Stefan, Prondzinsky, Roland, Felix, Stephan, Duengen, Hans-Dirk, Figulla, Hans-Reiner, Fischer, Sven, Behrens, Steffen, Stawowy, Philipp, Kruells-Muench, Juergen, Knebel, Fabian, Nienaber, Christoph, Werner, Dierk, Aron, Wilma, Remppis, Bjoern, Hambrecht, Rainer, Kisters, Klaus, Werner, Nikos, Hoffmann, Stefan, Rossol, Siegbert, Geiss, Ernst, Graf, Kristof, Hamann, Frank, von Scheidt, Wolfgang, Schwinger, Robert, Tebbe, Ulrich, Costard-Jaeckle, Angelika, Lueders, Stephan, Heitzer, Thomas, Leutermann-Oei, Marie-Louise, Braun-Dullaeus, Ruediger, Roehnisch, Jens-Uwe, Muth, Gerhard, Goette, Andreas, Rotter, Achim, Ebelt, Henning, Olbrich, Hans-Georg, Mitrovic, Veselin, Hengstenberg, Christian, Schellong, Sebastian, Zamolyi, Karoly, Vertes, Andras, Matoltsy, Andras, Palinkas, Attila, Herczeg, Bela, Apro, Dezso, Lupkovics, Geza, Tomcsanyi, Janos, Toth, Kalman, Mathur, Atul, Banker, Darshan, Bharani, Anil, Arneja, Jaspal, Khan, Aziz, Gadkari, Milind, Hiremath, Jagdish, Patki, Nitin, Kumbla, Makund, Santosh, M.J., Ravikishore, A.G., Abhaichand, Rajpal, Maniyal, Vijayakukmar, Nanjappa, Manjunath, Reddy, P. Naveen, Chockalingam, Kulasekaran, Premchand, Rajendra, Mahajan, Vijay, Lewis, Basil, Wexler, Dov, Shochat, Michael, Keren, Andre, Omary, Muhamad, Katz, Amos, Marmor, Alon, Lembo, Giuseppe, Di Somma, Salvatore, Boccanelli, Alessandro, Barbiero, Mario, Pajes, Giuseppe, De Servi, Stefano, Greco, Dott Cosimo, De Santis, Fernando, Floresta, Agata, Visconti, Luigi Oltrona, Piovaccari, Giancarlo, Cavallini, Claudio, Di Biase, Matteo, Masini, Dott Franco, Vassanelli, Corrado, Viecca, Maurizio, Cangemi, Dott Francesco, Pirelli, Salvatore, Borghi, Claudio, Volpe, Massimo, Branzi, Angelo, Percoco, Dott Giovanni, Severi, Silvia, Santini, Alberto, De Lorenzi, Ettore, Metra, Marco, Zacà, Valerio, Mortara, Andrea, Tranquilino, Francisco P., Babilonia, Noe A., Ferrolino, Arthur M., Manlutac, Benjamin, Dluzniewski, Miroslaw, Dzielinska, Zofia, Nowalany-Kozie, Ewa, Mazurek, Walentyna, Wierzchowiecki, Jerzy, Wysokinski, Andrzej, Szachniewicz, Joanna, Romanowski, Witold, Krauze-Wielicka, Magdalena, Jankowski, Piotr, Berkowski, Piotr, Szelemej, Roman, Kleinrok, Andrzej, Kornacewicz-Jac, Zdzislawa, Vintila, Marius, Vladoianu, Mircea, Militaru, Constantin, Dan, Gheorghe, Dorobantu, Maria, Dragulescu, Stefan, Kostenko, Victor, Vishnevsky, Alexandr, Goloschekin, Boris, Tyrenko, Vadim, Gordienko, Alexander, Kislyak, Oxana, Martsevich, Sergey, Kuchmin, Alexey, Karpov, Yurii, Fomin, Igor, Shvarts, Yury, Orlikova, Olga, Ershova, Olga, Berkovich, Olga, Sitnikova, Maria, Pakhomova, Inna, Boldueva, Svetlana, Tyurina, Tatiana, Simanenkov, Vladimir, Boyarkin, Mikhail, Novikova, Nina, Tereschenko, Sergey, Zadionchenko, Vladimir, Shogenov, Zaur, Gordeev, Ivan, Moiseev, Valentin, Wong, Raymond, Ong, Hean Yee, Le Tan, Ju, Goncalvesova, Eva, Kovar, Frantisek, Skalina, Ivan, Kasperova, Viera, Hojerova, Silvia, Szentivanyi, Miroslav, Stancak, Branislav, Babcak, Marian, Kycina, Peter, Poliacik, Pavol, Toth, Peter, Sirotiakova, Jana, de Sa, Esteban Lopez, Bueno, Manuel Gomez, Selles, Manuel Martinez, Cabrera, Jose Angel, Freire, Ramon Bover, Gonzalez Juanatey, Jose Ramon, Comin, Josep, Soriano, FranciscoRidocci, Lopez, Alejandro, Vicho, Raul, Lama, Manuel Geraldia, Schaufelberger, Maria, Brunotte, Richard, Ullman, Bengt, Hagerman, Inger, Cizinsky, Stella, Cherng, Wen-Jin, Yu, Wen-Chung, Kuo, Chi-Tai, Chang, Kuan-Cheng, Lai, Wen-Ter, Kuo, Jen-Yuan, Ural, Dilek, Badak, Ozer, Akin, Mustafa, Yigit, Zerrin, Yokusoglu, Mehmet, Yilmaz, Mehmet, Abaci, Adnan, Ebinc, Haksun, Perlman, Richard, Parish, David, Bergin, James, Burnham, Kenneth, Brown, Christopher, Lundbye, Justin, Williams, Celeste, Eisen, Howard, Juneman, Elizabeth, Joseph, Susan, Peberdy, Mary Ann, Peura, Jennifer, Gupta, Vishal, Habet, Kalim, French, William, Mody, Freny, Graham, Susan, Hazelrigg, Monica, Chung, Eugene, Dunlap, Stephanie, Nikolaidis, Lazaros, Najjar, Samer, Katz, Richard, Murali, Srinivas, Izzo, Joseph L., Callister, Tracy, Phillips, Roland, Lippolis, Nicholas, Winterton, John, Meymandi, Sheba, Heilman, Karl, Oren, Ron, Zolty, Ronald, Brottman, Michael, Gunawardena, D.R., Adams, Kirkwood, Barnard, Denise, Klapholz, Marc, and Fulmer, James

Abstract

Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.0

47. EVALUACIÓN DE LA MEMORIA DECLARATIVA ASOCIADA CON CONTENIDO EMOCIONAL EN PACIENTES LOBECTOMIZADOS.

Author

De Oliveira, Silvia Botelho, Prada, Lina María Acevedo, Cotes, Carlos Arturo Conde, Franky, Jaime Fandiño, and Tomaz, Carlos Alberto Bezerra

Subjects
*RESEARCH, *EXPLICIT memory, *EMOTIONS & cognition, *TEMPORAL lobe, *MEMORY, *CEREBRAL cortex, *THOUGHT & thinking
Abstract

Several studies have demonstrated that long-term declarative memory is enhanced by emotional arousal contents. Additionally, the role of the temporal lobe in memory associated to emotional stimuli has been evaluated through the audio-visual Emotional Memory Test, where emotional content is presented by complex narratives. The present study examined if Token Test's performance influenced the long-term retention associated to emotional arousal in patients undergoing unilateral temporal lobectomy. A sample of 48 volunteers, were evaluated by Trail Making Test, Token Test and audio-visual Test. Patients didn't show a mnemonic enhancement effect, particularly, those with left lobectomy. Low Token's performance did not show any correlation with audio-visual Test's performances. Results highlight the importance of left temporal lobe for long-term enhancement of declarative memory associated to emotional events. [ABSTRACT FROM AUTHOR]

Published
2008

48. Avaliação das respostas psicofisíologicas associadas à memória emocional em um teste auditivo-visual

Author

Valencia, Carlos Enrique Uribe, Tomaz, Carlos Alberto Bezerra, and Cotes, Carlos Arturo Conde

Subjects
Teste psicológico, Psicologia, Memória, Sistema nervoso autônomo, Memória emocional, Resposta autonômica
Abstract

Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, 2007. A facilitação da memória declarativa devida à emoção é o fenômeno pelo qual a informação relacionada ao conteúdo emocional é mais facilmente relembrada e permanece durante mais tempo disponível à evocação do que a informação não relacionada ao conteúdo emocional. O presente trabalho objetivou o estudo da relação entre alertamento emocional, pontuações subjetivas para as emoções básicas, sexo dos participantes e a atividade autonômica durante as fases de codificação e evocação da informação, utilizando um teste auditivo-visual de memória emocional. Os resultados demonstram que o conteúdo emocional da informação induziu maiores níveis de Alertamento, Surpresa, Medo, Raiva e Tristeza, e foi melhor relembrado do que a informação sem conteúdo emocional. Homens e mulheres reconheceram melhor as informações relacionadas ao seu papel social do que informações sem esta característica. As correlações entre escores emocionais e de reconhecimento demonstraram que o nível de alertamento está associado a sentimentos de Surpresa e emoções de valência negativa. A memória declarativa para o conteúdo emocional correlacionou-se positivamente à Surpresa e Tristeza nas mulheres, e negativamente à Raiva nos homens. O conteúdo emocional induziu uma atividade fisiológica (freqüência de pulso e condutância da pele) diferenciada durante as fases de codificação e evocação da informação, sugerindo uma correlação da atividade autonômica com o fenômeno de facilitação da memória. Durante a sessão de evocação homens e mulheres apresentaram respostas autonômicas diferentes. Estes resultados apóiam a hipótese de processamento diferenciado da informação emocional entre homens e mulheres, bem como sugerem uma interação entre o alertamento e a valência emocional, demonstrando sua importância no estudo dos mecanismos de memória emocional e no delineamento de futuros experimentos. _________________________________________________________________________________________ ABSTRACT The memory enhancement phenomenon is the process by which information related to emotional content is more easily remembered and remains available to recalling for more time than information not related to emotional content. The objective of this work was to study the relationship between arousal, subjective scores for basic emotions, sex of the participants and autonomic activity during encoding and recalling of the information, using an audio-visual test of emotional memory. The results demonstrated that the emotional content of the information induced higher level of Arousal, Surprise, Fear, Angry and Sadness, and was better remembered than the information without emotional content. Men and women recognized self-reference information better than information without such characteristic. Correlations between emotional and recognition scores demonstrated that Arousal level was associated to Surprise feelings and negative-valenced emotions. Declarative memory for emotional content was positive correlated to Surprise and Sadness in women, and negatively to Angry in men. The emotional content induced a differentiated physiological activity (pulse frequency and skin conductance) during encoding and recalling phases, suggesting a correlation of autonomic activity with the memory enhancing phenomenon. During the recalling session men and women showed different autonomic responses. These results support the hypothesis of a differentiated processing of emotional information between men and women, as well as interactions between arousal and emotional valence, demonstrating their importance in the study of the mechanisms of emotional memory and in the design of future experiments.

Published
2007

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