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2. Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis

Author

van Eijk, Anna Maria, Stepniewska, Kasia, Hill, Jenny, Taylor, Steve M., Rogerson, Stephen J., Cottrell, Gilles, Chico, R. Matthew, Gutman, Julie R., Tinto, Hallidou, Unger, Holger W., Yanow, Stephanie K., Accrombessi, Manfred, Adegnika, Ayola A., Ahmed, Rukhsana, Arango-Flórez, Eliana María, Arevalo-Herrera, Myriam, Arinaitwe, Emmanual, Arnaldo, Paulo, Ashorn, Per, Ashorn, Ulla, Bardaji, Azucena, Betuela, Inoni, Bharti, Praveen K., Bohissou, Francis, Bôtto-Menezes, Camila, Braun, Vera, Briand, Valerie, Briggs, Jessica, Castellanos, María Eugenia, Chandramohan, Daniel, Chaponda, Enesia Banda, Chitnis, Chetan, Cohee, Lauren M., Cot, Michel, d'Alessandro, Umberto, Denoeud-Ndam, Lise, Desai, Meghna, Dicko, Alassane, Ding, Xavier, Dorsey, Grant, Duffy, Patrick E., Elbadry, Maha A., Enosse, Sonia M., Fan, Yue, Fievet, Nadine, Fried, Michal, Genton, Blaise, Gonzalez, Raquel, Greenwood, Brian, Kalilani, Linda, Kattenberg, Johanna H., Kayentao, Kassoum, Khairallah, Carole, King, Christopher L., Kochar, Dhanpat Kumar, Kochar, Swati, Koukouikila-Koussounda, Felix, Landis, Sarah H., Laufer, Miriam K., Leke, Rose F., Macete, Eusebio, Maculuve, Sonia, Madanitsa, Mwayiwawo, Mahamar, Almahamoudou, Maleta, Ken, Malhotra, Indu, Zoleko Manego, Rella, Martinez-Espinosa, Flor Ernestina, Massougbodji, Achille, Mathanga, Don, Menegon, Michela, Menendez, Clara, Mens, Petra, Meremikwu, Martin, Mockenhaupt, Frank P., Mombo-Ngoma, Ghyslain, Mosha, Dominic, Mueller, Ivo, Nahum, Alain, Natureeba, Paul, Ndam, Nicaise, Ntoumi, Francine, Oduwole, Olabisi A., Okech, Bernard A., Ome-Kaius, Maria, Otieno, Kephas, Padilla, Norma, Ramharter, Michal, Rochford, Rosemary, Rosanas-Urgell, Anna, Ruperez, Maria, Sabourin, Katherine R., Sanz, Sergi, Schallig, Henk D., Scott, Susana, Sevene, Esperanca, Severini, Carlo, Tagbor, Harry, Taylor, Diane Wallace, Traore Coulibaly, Maminata, Vasquez, Ana, Walker-Abbey, Annie, Wylie, Blair J., Zannou, Djimon M., Meshnick, Stephen R., ter Kuile, Feiko O., Mayor, Alfredo, Taylor, Steve M, Rogerson, Stephen J, Chico, R Matthew, Gutman, Julie R, Tinto, Halidou, Unger, Holger W, Yanow, Stephanie K, Meshnick, Steven R, and ter Kuile, Feiko O

Published
2023
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5. Burden of malaria in pregnancy among adolescent girls compared to adult women in 5 sub-Saharan African countries: A secondary individual participant data meta-analysis of 2 clinical trials

Author

Pons-Duran, Clara, Mombo-Ngoma, Ghyslain, Macete, Eusebio, Desai, Meghna, Kakolwa, Mwaka A., Zoleko-Manego, Rella, Ouédragou, Smaïla, Briand, Valérie, Valá, Anifa, Kabanywanyi, Abdunoor M., Ouma, Peter, Massougbodji, Achille, Sevene, Esperança, Cot, Michel, Aponte, John J., Mayor, Alfredo, Slutsker, Laurence, Ramharter, Michael, Menéndez, Clara, and González, Raquel

Subjects
Pregnant girls -- Care and treatment -- Comparative analysis -- Statistics, Malaria -- Risk factors -- Statistics -- Patient outcomes, Pregnant women -- Comparative analysis -- Care and treatment -- Statistics, Biological sciences
Abstract

Background Malaria is among the top causes of death in adolescent girls (10 to 19 years) globally. Adolescent motherhood is associated with increased risk of adverse maternal and neonatal outcomes. The interaction of malaria, adolescence, and pregnancy is especially relevant in malaria endemic areas, where rates of adolescent pregnancy are high. However, data on burden of malaria among adolescent girls are limited. This study aimed at investigating whether adolescent girls were at a greater risk of experiencing malaria-related outcomes in pregnancy-parasitaemia and clinical disease-than adult women. Methods and findings An individual secondary participant-level meta-analysis was conducted using data from 5,804 pregnant women participating in 2 malaria prevention clinical trials in Benin, Gabon, Kenya, Mozambique, and Tanzania between 2009 and 2014. Of the sample, 1,201 participants were adolescent girls with a mean age of 17.5 years (standard deviation (SD) 1.3) and 886 (73.8%) of them primigravidae. Among the 4,603 adult women with mean age of 27.0 years (SD 5.4), 595 (12.9%) were primigravidae. Mean gestational age at enrolment was 20.2 weeks (SD 5.2) and 1,069 (18.4%) participants were HIV-infected. Women were followed monthly until the postpartum visit (1 month to 6 weeks after delivery). This study considered outcomes including clinical episodes during pregnancy, peripheral parasitaemia at delivery, and placental malaria. A 2-stage meta-analysis approach was followed by pooling single multivariable regression results into standard DerSimonian-Laird random-effects models. Adolescent girls were more likely than adult women to present with clinical malaria during pregnancy (incidence risk ratio (IRR) 1.70, 95% confidence interval (CI) 1.20; 2.39, p-value = 0.003, I.sup.2 = 0.0%, N = 4,092), peripheral parasitaemia at delivery (odds ratio (OR) 2.28, 95% CI 1.46; 3.55, p-value < 0.001, I.sup.2 = 0.0%, N = 3,977), and placental infection (OR 1.97, 95% CI 1.31; 2.98, p-value = 0.001, I.sup.2 = 1.4%, N = 4,797). Similar associations were observed among the subgroup of HIV-uninfected participants: IRR 1.72 (95% CI 1.22; 2.45, p-value = 0.002, I.sup.2 = 0.0%, N = 3,531) for clinical malaria episodes, OR 2.39 (95% CI 1.49; 3.86, p-value < 0.001, I.sup.2 = 0.0%, N = 3,053) for peripheral parasitaemia, and OR 1.88 (95% CI 1.06 to 3.33, p-value = 0.03, I.sup.2 = 34.9%, N = 3,847) for placental malaria. Among HIV-infected subgroups statistically significant associations were not observed. Similar associations were found in the subgroup analysis by gravidity. The small sample size and outcome prevalence in specific countries limited the inclusion of some countries in the meta-analysis. Furthermore, peripheral parasitaemia and placental malaria presented a considerable level of missing data-12.6% and 18.2% of participants had missing data on those outcomes, respectively. Given the original scope of the clinical trials, asymptomatic malaria infection was only assessed at the end of pregnancy through peripheral and placental parasitaemia. Conclusions In this study, we observed that adolescent girls in sub-Saharan Africa (SSA) are more prone to experience clinical malaria episodes during pregnancy and have peripheral malaria and placental infection at delivery than adult women. Moreover, to the best of our knowledge, for the first time this study disaggregates figures and stratifies analyses by HIV infection. Similar associations were found for both HIV-infected and uninfected women, although those for HIV-infected participants were not statistically significant. Our finding suggests that adolescent girls may benefit from targeted malaria prevention strategies even before they become pregnant., Author(s): Clara Pons-Duran 1,2, Ghyslain Mombo-Ngoma 3,4,5, Eusebio Macete 6, Meghna Desai 7, Mwaka A. Kakolwa 8, Rella Zoleko-Manego 3,4,5, Smaïla Ouédragou 9,10, Valérie Briand 11,12, Anifa Valá 6, Abdunoor [...]

Published
2022
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6. VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

Author

Fonseca, Ana Maria, Gonzalez, Raquel, Bardaji, Azucena, Jairoce, Chenjerai, Ruperez, Maria, Jimenez, Alfons, Quinto, Llorenc, Cistero, Pau, Vala, Anifa, Sacoor, Charfudin, Gupta, Himanshu, Hegewisch-Taylor, Jennifer, Brew, Joe, Ndam, Nicaise Tuikue, Kariuki, Simon, Lopez, Marta, Dobano, Carlota, Chitnis, Chetan E., Ouma, Peter, Ramharter, Michael, Abdulla, Salim, Aponte, John J., Massougbodji, Achille, Briand, Valerie, Mombo-Ngoma, Ghyslain, Desai, Meghna, Cot, Michel, Nhacolo, Arsenio, Sevene, Esperanca, Macete, Eusebio, Menendez, Clara, and Mayor, Alfredo

Subjects
Disease transmission -- Health aspects, Peptides -- Health aspects, Medical research -- Health aspects, Infection -- Health aspects, Plasmodium falciparum -- Health aspects, Malaria -- Health aspects, Pregnancy -- Health aspects, Immune response -- Health aspects, EDTA -- Health aspects, Pregnant women -- Health aspects, Immunoglobulin G -- Health aspects, Antigens, Antibodies, Health
Abstract

Agile malaria surveillance and response systems that can be sustained over time are needed for the optimal design of control programs (1,2). Rates of Plasmodium falciparum infection among pregnant women [...]

Published
2019
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7. The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.

Author

WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik, Martin A, Allan, Richard, Anvikar, Anupkumar R, Ashley, Elizabeth A, Ba, Mamadou S, Barennes, Hubert, Barnes, Karen I, Bassat, Quique, Baudin, Elisabeth, Björkman, Anders, Bompart, François, Bonnet, Maryline, Borrmann, Steffen, Brasseur, Philippe, Bukirwa, Hasifa, Checchi, Francesco, Cot, Michel, Dahal, Prabin, D'Alessandro, Umberto, Deloron, Philippe, Desai, Meghna, Diap, Graciela, Djimde, Abdoulaye A, Dorsey, Grant, Doumbo, Ogobara K, Espié, Emmanuelle, Etard, Jean-Francois, Fanello, Caterina I, Faucher, Jean-François, Faye, Babacar, Flegg, Jennifer A, Gaye, Oumar, Gething, Peter W, González, Raquel, Grandesso, Francesco, Guerin, Philippe J, Guthmann, Jean-Paul, Hamour, Sally, Hasugian, Armedy Ronny, Hay, Simon I, Humphreys, Georgina S, Jullien, Vincent, Juma, Elizabeth, Kamya, Moses R, Karema, Corine, Kiechel, Jean R, Kremsner, Peter G, Krishna, Sanjeev, Lameyre, Valérie, Ibrahim, Laminou M, Lee, Sue J, Lell, Bertrand, Mårtensson, Andreas, Massougbodji, Achille, Menan, Hervé, Ménard, Didier, Menéndez, Clara, Meremikwu, Martin, Moreira, Clarissa, Nabasumba, Carolyn, Nambozi, Michael, Ndiaye, Jean-Louis, Nikiema, Frederic, Nsanzabana, Christian, Ntoumi, Francine, Ogutu, Bernhards R, Olliaro, Piero, Osorio, Lyda, Ouédraogo, Jean-Bosco, Penali, Louis K, Pene, Mbaye, Pinoges, Loretxu, Piola, Patrice, Price, Ric N, Roper, Cally, Rosenthal, Philip J, Rwagacondo, Claude Emile, Same-Ekobo, Albert, Schramm, Birgit, Seck, Amadou, Sharma, Bhawna, Sibley, Carol Hopkins, Sinou, Véronique, Sirima, Sodiomon B, Smith, Jeffery J, Smithuis, Frank, Somé, Fabrice A, Sow, Doudou, Staedke, Sarah G, Stepniewska, Kasia, Swarthout, Todd D, Sylla, Khadime, Talisuna, Ambrose O, Tarning, Joel, Taylor, Walter RJ, Temu, Emmanuel A, Thwing, Julie I, Tjitra, Emiliana, and Tine, Roger CK

Subjects
WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Humans, Malaria, Falciparum, Recurrence, Artemisinins, Amodiaquine, Drug Combinations, Antimalarials, Treatment Outcome, Risk Factors, Dose-Response Relationship, Drug, Middle Aged, Africa, Female, Male, Malaria, Plasmodium falciparum, Drug resistance, Artesunate, Dosing, Efficacy, Falciparum, Dose-Response Relationship, Drug, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundArtesunate-amodiaquine (AS-AQ) is one of the most widely used artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum malaria in Africa. We investigated the impact of different dosing strategies on the efficacy of this combination for the treatment of falciparum malaria.MethodsIndividual patient data from AS-AQ clinical trials were pooled using the WorldWide Antimalarial Resistance Network (WWARN) standardised methodology. Risk factors for treatment failure were identified using a Cox regression model with shared frailty across study sites.ResultsForty-three studies representing 9,106 treatments from 1999-2012 were included in the analysis; 4,138 (45.4%) treatments were with a fixed dose combination with an AQ target dose of 30 mg/kg (FDC), 1,293 (14.2%) with a non-fixed dose combination with an AQ target dose of 25 mg/kg (loose NFDC-25), 2,418 (26.6%) with a non-fixed dose combination with an AQ target dose of 30 mg/kg (loose NFDC-30), and the remaining 1,257 (13.8%) with a co-blistered non-fixed dose combination with an AQ target dose of 30 mg/kg (co-blistered NFDC). The median dose of AQ administered was 32.1 mg/kg [IQR: 25.9-38.2], the highest dose being administered to patients treated with co-blistered NFDC (median = 35.3 mg/kg [IQR: 30.6-43.7]) and the lowest to those treated with loose NFDC-25 (median = 25.0 mg/kg [IQR: 22.7-25.0]). Patients treated with FDC received a median dose of 32.4 mg/kg [IQR: 27-39.0]. After adjusting for reinfections, the corrected antimalarial efficacy on day 28 after treatment was similar for co-blistered NFDC (97.9% [95% confidence interval (CI): 97.0-98.8%]) and FDC (98.1% [95% CI: 97.6%-98.5%]; P = 0.799), but significantly lower for the loose NFDC-25 (93.4% [95% CI: 91.9%-94.9%]), and loose NFDC-30 (95.0% [95% CI: 94.1%-95.9%]) (P

Published
2015

8. Infected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria.

Author

Fraering, Jeremy, Salnot, Virginie, Gautier, Emilie-Fleur, Ezinmegnon, Sem, Argy, Nicolas, Peoc'h, Katell, Manceau, Hana, Alao, Jules, Guillonneau, François, Migot-Nabias, Florence, Bertin, Gwladys I, Kamaliddin, Claire, Aubouy, Agnes, Affolabi, Dissou, Biokou, Bibiane, Cot, Michel, Degbelo, Jean-Eudes, Deloron, Philippe, Dramane, Latifou, and Faucher, Jean-François

Abstract

Cerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), remains fatal for 15–25% of affected children despite the availability of treatment. P. falciparum infects and multiplies in erythrocytes, contributing to anemia, parasite sequestration, and inflammation. An unbiased proteomic assessment of infected erythrocytes and plasma samples from 24 Beninese children was performed to study the complex mechanisms underlying CM. A significant down-regulation of proteins from the ubiquitin–proteasome pathway and an up-regulation of the erythroid precursor marker transferrin receptor protein 1 (TFRC) were associated with infected erythrocytes from CM patients. At the plasma level, the samples clustered according to clinical presentation. Significantly, increased levels of the 20S proteasome components were associated with SM. Targeted quantification assays confirmed these findings on a larger cohort (n = 340). These findings suggest that parasites causing CM preferentially infect reticulocytes or erythroblasts and alter their maturation. Importantly, the host plasma proteome serves as a specific signature of SM and presents a remarkable opportunity for developing innovative diagnostic and prognostic biomarkers. Synopsis: A mass spectrometry-based proteomic screening of both plasma and infected erythrocytes from Beninese children with various clinical manifestations of malaria (Uncomplicated Malaria (UM), Severe Malarial Anemia (SMA), and Cerebral Malaria (CM)) was performed. An increase of TFRC abundance was observed in infected erythrocyte samples from CM patients when compared to UM patients, coupled with a decrease of plasmatic Transferrin levels. 20S proteasome abundance was increased in plasma from children with severe malaria (CM and SMA) compared to UM, suggesting that it could serve as potential biomarker of severe malaria. A deregulated iron metabolism pathway and an increased hemolytic anemia were described in the severe malaria groups. Six P. falciparum proteins involved in red blood cell invasion were quantified specifically in plasma samples from severe malaria cases. A mass spectrometry-based proteomic screening of both plasma and infected erythrocytes from Beninese children with various clinical manifestations of malaria (Uncomplicated malaria (UM), Severe Malarial Anemia (SMA), and Cerebral Malaria (CM)) was performed. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Prevention of malaria in pregnancy

Author

Desai, Meghna, Hill, Jenny, Fernandes, Silke, Walker, Patrick, Pell, Christopher, Gutman, Julie, Kayentao, Kassoum, Gonzalez, Raquel, Webster, Jayne, Greenwood, Brian, Cot, Michel, and ter Kuile, Feiko O

Published
2018
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13. Miriades methodology guide

Author

Cot, Michel, primary, Emperaire, Laure, additional, Henry, Isabelle, additional, Laplaze, Laurent, additional, Roubaud, François, additional, Sylvestre, Florence, additional, Vidal, Laurent, additional, and Zucker, Jean-Daniel, additional

Published
2023
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14. Guide méthodologique Miriades

Author

Cot, Michel, primary, Emperaire, Laure, additional, Henry, Isabelle, additional, Laplaze, Laurent, additional, Roubaud, François, additional, Sylvestre, Florence, additional, Vidal, Laurent, additional, and Zucker, Jean-Daniel, additional

Published
2023
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16. Societal impact assessments of research for sustainability science

Author

Cot, Michel, Emperaire, Laure, Henry, Isabelle, Roubaud, François, Sylvestre, Florence, Vidal, Laurent, Zucker, Jean-Daniel, Martin, Eric, Thirion, Ghislaine, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Patrimoines locaux, Environnement et Globalisation (PALOC), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU), Institut de Recherche pour le Développement (IRD), Développement, Institutions et Modialisation (LEDA-DIAL), Laboratoire d'Economie de Dauphine (LEDa), Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO), Université de Yaoundé I-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD [France-Nord]), Dangles, Olivier (coord.), and Fréour, Claire (coord.)

Subjects
[SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, ORGANISME DE RECHERCHE, STRATEGIE DE RECHERCHE, RECHERCHE SCIENTIFIQUE, [SDE.ES]Environmental Sciences/Environmental and Society
Published
2023

17. Elevated plasma IL-8 as a risk factor for mortality in children presenting with cerebral malaria (NeuroCM study)

Author

Royo, Jade, primary, Vianou, Bertin, additional, Accrombessi, Manfred, additional, Kinkpé, Elisée, additional, Ayédadjou, Linda, additional, Dossou-Dagba, Ida, additional, Ladipo, Yélé, additional, Alao, Maroufou Jules, additional, Bertin, Gwladys I, additional, Cot, Michel, additional, Boumediene, Farid, additional, Houzé, Sandrine, additional, Faucher, Jean-François, additional, Aubouy, Agnès, additional, and group, collaborators NeuroCM, additional

Published
2022
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18. Lead Exposure in Infancy and Subsequent Growth in Beninese Children

Author

Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Ayotte, Pierre, additional, Fievet, Nadine, additional, Massougbodji, Achille, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional

Published
2022
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19. Impact of mobile phone intervention on intermittent preventive treatment of malaria during pregnancy in Burkina Faso : A pragmatic randomized trial

Author

Ouédraogo, Smaïla, primary, Accrombessi, Manfred, additional, Ouattara, Adama, additional, Massougbodji, Achille, additional, Dabira, Edgard D., additional, Sarigda, Maurice, additional, Diallo, Ismaël, additional, Zida, Adama, additional, Nicolas, Méda, additional, Ouédraogo, Laurent, additional, Cot, Michel, additional, and Sondo, Blaise, additional

Published
2022
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20. Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data

Author

Mansoor, Rashid, Commons, Robert J, Douglas, Nicholas M, Abuaku, Benjamin, Achan, Jane, Adam, Ishag, Adjei, George O, Adjuik, Martin, Alemayehu, Bereket H, Allan, Richard, Allen, Elizabeth N, Anvikar, Anupkumar R, Arinaitwe, Emmanuel, Ashley, Elizabeth A, Ashurst, Hazel, Asih, Puji BS, Bakyaita, Nathan, Barennes, Hubert, Barnes, Karen I, Basco, Leonardo, Bassat, Quique, Baudin, Elisabeth, Bell, David J, Bethell, Delia, Bjorkman, Anders, Boulton, Caroline, Bousema, Teun, Brasseur, Philippe, Bukirwa, Hasifa, Burrow, Rebekah, Carrara, Verena I, Cot, Michel, D'Alessandro, Umberto, Das, Debashish, Das, Sabyasachi, Davis, Timothy ME, Desai, Meghna, Djimde, Abdoulaye A, Dondorp, Arjen M, Dorsey, Grant, Drakeley, Chris J, Duparc, Stephan, Espie, Emmanuelle, Etard, Jean-Francois, Falade, Catherine, Faucher, Jean Francois, Filler, Scott, Fogg, Carole, Fukuda, Mark, Gaye, Oumar, Genton, Blaise, Rahim, Awab Ghulam, Gilayeneh, Julius, Gonzalez, Raquel, Grais, Rebecca F, Grandesso, Francesco, Greenwood, Brian, Grivoyannis, Anastasia, Hatz, Christoph, Hodel, Eva Maria, Humphreys, Georgina S, Hwang, Jimee, Ishengoma, Deus, Juma, Elizabeth, Kachur, S Patrick, Kager, Piet A, Kamugisha, Erasmus, Kamya, Moses R, Karema, Corine, Kayentao, Kassoum, Kazienga, Adama, Kiechel, Jean-Rene, Kofoed, Poul-Erik, Koram, Kwadwo, Kremsner, Peter G, Lalloo, David G, Laman, Moses, Lee, Sue J, Lell, Bertrand, Maiga, Amelia W, Martensson, Andreas, Mayxay, Mayfong, Mbacham, Wilfred, McGready, Rose, Menan, Herve, Menard, Didier, Mockenhaupt, Frank, Moore, Brioni R, Muller, Olaf, Nahum, Alain, Ndiaye, Jean-Louis, Newton, Paul N, Ngasala, Billy E, Nikiema, Frederic, Nji, Akindeh M, Noedl, Harald, Nosten, Francois, Ogutu, Bernhards R, Ojurongbe, Olusola, Osorio, Lyda, Ouedraogo, Jean-Bosco, Owusu-Agyei, Seth, Pareek, Anil, Penali, Louis K, Piola, Patrice, Plucinski, Mateusz, Premji, Zul, Ramharter, Michael, Richmond, Caitlin L, Rombo, Lars, Rosenthal, Philip J, Salman, Sam, Same-Ekobo, Albert, Sibley, Carol, Sirima, Sodiomon B, Smithuis, Frank M, Some, Fabrice A, Staedke, Sarah G, Starzengruber, Peter, Strub-Wourgaft, Nathalie, Sutanto, Inge, Swarthout, Todd D, Syafruddin, Din, Talisuna, Ambrose O, Taylor, Walter R, Temu, Emmanuel A, Thwing, Julie I, Tinto, Halidou, Tjitra, Emiliana, Toure, Offianan A, Tran, T Hien, Ursing, Johan, Valea, Innocent, Valentini, Giovanni, van Vugt, Michele, von Seidlein, Lorenz, Ward, Stephen A, Were, Vincent, White, Nicholas J, Woodrow, Charles J, Yavo, William, Yeka, Adoke, Zongo, Issaka, Simpson, Julie A, Guerin, Philippe J, Stepniewska, Kasia, Price, Ric N, Roper, Cally, Resistance, WorldWide Antimalarial, WorldWide Antimalarial Resistance Network Falciparum Haematology Study Group, Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Epidémiologie des Maladies Chroniques en zone tropicale (EpiMaCT), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-OmégaHealth (ΩHealth), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Group, WorldWide Antimalarial Resistance Network Falciparum Haematology Study, Mansoor, R, Ashley, EA, Ashurst, H, Burrow, R, Carrara, VI, Das, D, Dondorp, AM, Humphreys, GS, Lee, SJ, Mayxay, M, McGready, R, Newton, PN, Nosten, F, Richmond, CL, Sibley, C, Smithuis, FM, Taylor, WR, Tran, TH, von Seidlein, L, White, NJ, Woodrow, CJ, Guerin, PJ, Stepniewska, K, Price, RN, AII - Infectious diseases, Intensive Care Medicine, Infectious diseases, APH - Global Health, and APH - Quality of Care

Subjects
Infectious Medicine, Plasmodium falciparum, wh_120, Infektionsmedicin, Severe anaemia, Parasitemia, wa_530, Antimalarials, Non-artemisinin-based therapy, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, parasitic diseases, qv_256, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Malaria, Falciparum, Child, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Pooled analysis of individual patient data, Anemia, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Artemisinin-based therapy, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Malaria, wc_750, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Haemoglobin
Abstract

Background Plasmodium falciparum malaria is associated with anaemia-related morbidity, attributable to host, parasite and drug factors. We quantified the haematological response following treatment of uncomplicated P. falciparum malaria to identify the factors associated with malarial anaemia. Methods Individual patient data from eligible antimalarial efficacy studies of uncomplicated P. falciparum malaria, available through the WorldWide Antimalarial Resistance Network data repository prior to August 2015, were pooled using standardised methodology. The haematological response over time was quantified using a multivariable linear mixed effects model with nonlinear terms for time, and the model was then used to estimate the mean haemoglobin at day of nadir and day 7. Multivariable logistic regression quantified risk factors for moderately severe anaemia (haemoglobin < 7 g/dL) at day 0, day 3 and day 7 as well as a fractional fall ≥ 25% at day 3 and day 7. Results A total of 70,226 patients, recruited into 200 studies between 1991 and 2013, were included in the analysis: 50,859 (72.4%) enrolled in Africa, 18,451 (26.3%) in Asia and 916 (1.3%) in South America. The median haemoglobin concentration at presentation was 9.9 g/dL (range 5.0–19.7 g/dL) in Africa, 11.6 g/dL (range 5.0–20.0 g/dL) in Asia and 12.3 g/dL (range 6.9–17.9 g/dL) in South America. Moderately severe anaemia (Hb < 7g/dl) was present in 8.4% (4284/50,859) of patients from Africa, 3.3% (606/18,451) from Asia and 0.1% (1/916) from South America. The nadir haemoglobin occurred on day 2 post treatment with a mean fall from baseline of 0.57 g/dL in Africa and 1.13 g/dL in Asia. Independent risk factors for moderately severe anaemia on day 7, in both Africa and Asia, included moderately severe anaemia at baseline (adjusted odds ratio (AOR) = 16.10 and AOR = 23.00, respectively), young age (age < 1 compared to ≥ 12 years AOR = 12.81 and AOR = 6.79, respectively), high parasitaemia (AOR = 1.78 and AOR = 1.58, respectively) and delayed parasite clearance (AOR = 2.44 and AOR = 2.59, respectively). In Asia, patients treated with an artemisinin-based regimen were at significantly greater risk of moderately severe anaemia on day 7 compared to those treated with a non-artemisinin-based regimen (AOR = 2.06 [95%CI 1.39–3.05], p < 0.001). Conclusions In patients with uncomplicated P. falciparum malaria, the nadir haemoglobin occurs 2 days after starting treatment. Although artemisinin-based treatments increase the rate of parasite clearance, in Asia they are associated with a greater risk of anaemia during recovery.

Published
2022

24. Lead Exposure in Infancy and Subsequent Childhood Growth

Author

Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Ayotte, Pierre, additional, Fievet, Nadine, additional, Massougbodji, Achille, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional

Published
2022
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27. Les études d'impact sociétal de la recherche au service de la science de la durabilité

Author

Cot, Michel, Emperaire, Laure, Henry, Isabelle, Roubaud, François, Sylvestre, Florence, Vidal, Laurent, Zucker, Jean-Daniel, Martin, Eric, Thirion, Ghislaine, HORIZON, IRD, Dangles, Olivier (coord.), Fréour, Claire (coord.), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Patrimoines locaux, Environnement et Globalisation (PALOC), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU), Institut de recherche pour le développement (IRD [Sénégal]), Développement, Institutions et Modialisation (LEDA-DIAL), Laboratoire d'Economie de Dauphine (LEDa), Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Dauphine-PSL, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD), Unité de modélisation mathématique et informatique des systèmes complexes [Bondy] (UMMISCO), and Université de Yaoundé I-Institut de la francophonie pour l'informatique-Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD)-Université Gaston Bergé (Saint-Louis, Sénégal)-Université Cadi Ayyad [Marrakech] (UCA)-Sorbonne Université (SU)-Institut de Recherche pour le Développement (IRD [France-Nord])

Subjects
[SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, ORGANISME DE RECHERCHE, STRATEGIE DE RECHERCHE, [SHS.HISPHILSO] Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, [SDE.ES] Environmental Sciences/Environmental and Society, RECHERCHE SCIENTIFIQUE, [SDE.ES]Environmental Sciences/Environmental and Society
Published
2022

28. Additional file 1 of Non-traumatic coma in young children in Benin: are viral and bacterial infections gaining ground on cerebral malaria?

Author

Brisset, Josselin, Angendu Baki, Karl, Watier, Laurence, Kinkp��, Elis��e, Bailly, Justine, Ay��dadjou, Linda, Alao, Maroufou Jules, Dossou-Dagba, Ida, Bertin, Gwladys I., Cot, Michel, Boum��di��ne, Farid, Ajzenberg, Daniel, Aubouy, Agn��s, Houz��, Sandrine, and Faucher, Jean-Fran��ois

Abstract

Additional file 1: Figure S1. Map of Benin with focus on Cotonou and the 2 study sites. Figure S2. Coma etiologies: graphical presentation.

Published
2022
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29. Malaria in the First Trimester of Pregnancy and Fetal Growth: Results from a Beninese Preconceptional Cohort

Author

Koladjo, Babagnidé François, primary, Yovo, Emmanuel, additional, Accrombessi, Manfred, additional, Agbota, Gino, additional, Atade, William, additional, Ladikpo, Olaiitan T, additional, Mehoba, Murielle, additional, Degbe, Auguste, additional, Jackson, Nikki, additional, Massougbodji, Achille, additional, Sossou, Darius, additional, Vianou, Bertin, additional, Cot, Michel, additional, Cottrell, Gilles, additional, Fievet, Nadine, additional, Zeitlin, Jennifer, additional, and Briand, Valérie, additional

Published
2022
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31. Comparison of Sulfadoxine-Pyrimethamine, Unsupervised Artemether-Lumefantrine, and Unsupervised Artesunate-Amodiaquine Fixed-Dose Formulation for Uncomplicated Plasmodium falciparum Malaria in Benin: A Randomized Effectiveness Noninferiority Trial

Author

Faucher, Jean-François, Aubouy, Agnès, Adeothy, Adicat, Cottrell, Gilles, Doritchamou, Justin, Gourmel, Bernard, Houzé, Pascal, Kossou, Hortense, Amedome, Hyacinthe, Massougbodji, Achille, Cot, Michel, and Deloron, Philippe

Published
2009
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33. The Impact of Maternal Depression and Parent–Child Interactions on Risk of Parasitic Infections in Early Childhood: A Prospective Cohort in Benin

Author

Garrison, Amanda, primary, Maselko, Joanna, additional, Saurel-Cubizolles, Marie-Josèphe, additional, Courtin, David, additional, Zoumenou, Roméo, additional, Boivin, Michael J., additional, Massougbodji, Achille, additional, Garcia, André, additional, Alao, Maroufou Jules, additional, Cot, Michel, additional, Maman, Suzanne, additional, and Bodeau-Livinec, Florence, additional

Published
2021
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34. Pre-conception serum ferritin concentrations are associated with metal concentrations in blood during pregnancy: A cohort study in Benin

Author

Davies, Sarah, primary, Briand, Valérie, additional, Accrombessi, Manfred, additional, Fievet, Nadine, additional, Le Bot, Barbara, additional, Durand, Séverine, additional, Agbota, Gino, additional, Yovo, Emmanuel, additional, Vianou, Bertin, additional, Sossou, Darius, additional, Martin-Prevel, Yves, additional, Massougbodji, Achille, additional, Cot, Michel, additional, Glorennec, Philippe, additional, and Bodeau-Livinec, Florence, additional

Published
2021
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35. The effects of malaria in pregnancy on neurocognitive development in children at one and six years of age in Benin: a prospective mother-child cohort

Author

Garrison, Amanda, Boivin, Michael, Fiévet, Nadine, Zoumenou, Roméo, Alao, Jules, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, École des Hautes Études en Santé Publique [EHESP] (EHESP), Michigan State University [East Lansing], Michigan State University System, Centre Hospitalier Universitaire de la Mère et de l’Enfant–Lagune de Cotonou, Université d’Abomey-Calavi (UAC), and Département Méthodes quantitatives en santé publique (METIS)

Subjects
Sub-Saharan Africa, Pregnancy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Child development, Neurocognition, Malaria
Abstract

Accepted manuscript; International audience; Background - Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in Sub-Saharan Africa and has consequences on survivors, such as pre-term birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown. Methods - Our prospective cohort included pregnant women and their live-born singletons from the Malaria in Pregnancy Preventive Alternative Drugs clinical trial. MiP was assessed using microscopy and real-time quantitative polymerase chain-reactions (qPCR). Neurocognitive development in children was assessed using the Mullen Scales of Early Learning and the Kaufman Assessment Battery for Children 2 nd edition (KABC-II) at one and six years of age, respectively. Results - Of 493 pregnant women, 196 (40%) were infected with malaria at least once; 121 (31%) with placental malaria diagnosed by qPCR. Multiple linear regression beta coefficients showed that impaired gross motor scores were associated with MiP at least once [-2.55 Confidence Interval (CI) (-5.15, 0.05)], placental malaria by qPCR [-4.95 CI (-7.65, -2.24)], and high parasite density at delivery [-1.92 CI (-3.86, 0.02)] after adjustment. Malaria and high parasite density at the 2 nd ANV were associated with lower KABC-II Non-Verbal Index scores at six years [-2.57 CI (-4.86, -0.28)] and [-1.91 CI (-3.51, -0.32)], respectively. Conclusions - This prospective cohort study provides evidence that MiP, particularly late-term, could have important negative consequences on child development at one and six years of age. Mechanisms behind this association must be further investigated and diagnostic methods in low-income countries should be strengthened to provide adequate treatment.

Published
2021

38. Lead exposure in infancy and subsequent growth in childhood

Author

Ahmadi, Shukrullah, primary, Botton, Jérémie, additional, Zoumenou, Roméo, additional, Fiévet, Nadine, additional, Ayotte, Pierre, additional, Massougbodji, Achille, additional, Alao, Jules Maroufou, additional, Cot, Michel, additional, and Bodeau Livinec, Florence, additional

Published
2021
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41. Soil-transmitted helminth infection in pregnancy and long-term child neurocognitive and behavioral development: A prospective mother-child cohort in Benin

Author

Garrison, Amanda, Boivin, Michael, Khoshnood, Babak, Courtin, David, Alao, Jules, Mireku, Michael, Ibikounle, Moudachirou, Massougbodji, Achille, Cot, Michel, Bodeau-Livinec, Florence, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Michigan State University [East Lansing], Michigan State University System, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), University of Lincoln, Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Fondation de France (2015 00060746), Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD- R21-HD060524), European and Developing Countries Clinical Trials Partnership (EDCTP- IP.07.31080.002), Bill and Melinda Gates Foundation, EHESP, SCD, Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), and Université d’Abomey-Calavi (UAC)

Subjects
Maternal Health, Emotions, RC955-962, Helminthiasis, Child Behavior, Social Sciences, Cohort Studies, C890 Psychology not elsewhere classified, Soil, Families, C810 Applied Psychology, Child Development, Cognition, Medical Conditions, Pregnancy, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Arctic medicine. Tropical medicine, Medicine and Health Sciences, Psychology, Prospective Studies, C820 Developmental Psychology, Child, Children, Immune Response, Cognitive Neurology, Neuropsychological testing, Eukaryota, Obstetrics and Gynecology, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Cognitive impairment, Neurology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Public aspects of medicine, RA1-1270, B990 Subjects Allied to Medicine not elsewhere classified, Research Article, Adult, Helminth infections, Cognitive Neuroscience, Immunology, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Signs and Symptoms, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Helminths, Parasitic Diseases, Humans, Animals, Inflammation, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Organisms, Biology and Life Sciences, Invertebrates, [SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Age Groups, Hookworms, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Pregnancy Complications, Parasitic, People and Places, Women's Health, Cognitive Science, Population Groupings, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Clinical Medicine, Zoology, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, Neuroscience
Abstract

Background An estimated 30% of women in Sub-Saharan Africa suffer from soil-transmitted helminth infection during pregnancy (SHIP), which has been shown to increase risk of pre-term birth, low birth weight, and maternal anemia. A previous study in Benin found that SHIP was associated with impaired cognitive and gross motor development scores in 635 one-year-old children. The objective of the present study was to follow children prospectively to investigate whether the association between SHIP and child neurocognitive and behavioral development persisted at age six. Principal findings Our prospective child cohort included 487 live-born singletons of pregnant women enrolled in the Malaria in Pregnancy Preventive Alternative Drugs clinical trial in Allada, Benin. SHIP was assessed at three antenatal visits (ANVs) through collection and testing of stool samples. Neurocognitive and behavioral development was assessed in six-year-old children by trained investigators using the Kaufman Assessment Battery for Children 2nd edition and the parent-reported Strengths and Difficulties Questionnaire (SDQ). Multiple linear regression models generated coefficients and 95% confidence intervals and potential mediating factors were tested. Prevalence of SHIP was 13% at the 1st ANV, 9% at the 2nd ANV, and 1% at delivery. SHIP was not associated with low neurocognitive scores in children at six years. Higher SDQ internalizing scores, indicating increased emotional impairments in children, were associated with helminth infection at the 2nd ANV/delivery 1.07 (95% CI 0.15, 2.00) and at least once during pregnancy 0.79 (95% CI 0.12, 1.46) in adjusted models. Mediation analysis did not reveal significant indirect effects of several mediators on this association. Conclusions Our study shows that while SHIP is not associated with impaired long-term neurocognitive development, infections may have significant negative impacts on emotional development in six-year-old children. SHIP remains a critical public health issue, and adequate prevention and treatment protocols should be enforced in low- and middle-income countries., Author summary Soil-transmitted helminth infections impact 1.5 billion individuals, primarily in low- and middle- income countries, each year and contribute to malnutrition, anemia, and impaired neurocognitive development in children. However, these infections in pregnancy and their impact on offspring have been less studied. One previous study found associations between soil-transmitted helminth infection during pregnancy and impaired cognitive functioning in offspring one year after birth. The current study aimed to follow these children prospectively until six years in order to confirm whether these associations persisted or not. Infections during pregnancy were no longer associated with cognitive or motor functioning in children; however, infections were associated with impaired behavioral development. Animal-based models have hypothesized maternal inflammation and poor birth outcomes to be the mechanisms behind this relationship; however, our findings did not support these mechanisms. This is one of very few prospective cohort studies in Sub-Saharan Africa to investigate these associations, and more research is needed to corroborate results. Limitations include limited power and the possibility that results are due to chance from multiple statistical tests. Adequate and accessible prevention and treatment efforts in pregnancy and childhood should be provided to populations in low- and middle- income countries at high risk of infection.

Published
2021

42. Sulfadoxine/pyrimethamine intermittent preventive treatment for malaria during pregnancy

Author

Deloron, Philippe, Bertin, Gwladys, Briand, Valerie, Massougbodji, Achille, and Cot, Michel

Subjects
Medicine, Preventive, Pregnancy, Antimalarials, Infection -- Drug therapy -- Genetic aspects, Public health, Preventive health services, Malaria -- Drug therapy -- Genetic aspects, Pregnant women -- Drug therapy, Plasmodium falciparum, Dihydrofolate reductase, Health, World Health Organization
Abstract

Malaria during pregnancy is a major cause of anemia and maternal death and one of the main causes of low birthweight (1,2). Consequently, the World Health Organization (WHO) recommends protection [...]

Published
2010
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44. Comprehensive Analysis of Transcript and Protein Relative Abundance During Blood Stages of Plasmodium falciparum Infection

Author

Kamaliddin, Claire, primary, Guillochon, Emilie, additional, Salnot, Virginie, additional, Rombaut, David, additional, Huguet, Stéphanie, additional, Guillonneau, François, additional, Houzé, Sandrine, additional, Cot, Michel, additional, Deloron, Philippe, additional, Argy, Nicolas, additional, and Bertin, Gwladys I., additional

Published
2021
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45. Comparison of growth models to describe growth from birth to 6 years in a Beninese cohort of children with repeated measurements

Author

Ahmadi, Shukrullah, Bodeau-Livinec, Florence, Zoumenou, Roméo, Garcia, André, Courtin, David, Alao, Jules, Fievet, Nadine, Cot, Michel, Massougbodji, Achille, Botton, Jérémie, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École des Hautes Études en Santé Publique [EHESP] (EHESP), Institut de Recherche pour le Développement [Cotonou, Bénin] (IRD), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 261), Institut de Recherche pour le Développement (IRD)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune (CHU-MEL), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Pharmaco-épidémiologie des produits de santé et sécurité sanitaire [Site de Saint Denis] (GIS EPIPHARE - ANSM), Agence nationale de sécurité du médicament et des produits de santé [Saint-Denis] (ANSM), European and Developing Countries Clinical Trials Partnership (EDCTP)IP.2007.31080.002Malaria in Pregnancy ConsortiumInstituto de Salud Carlos IIIPI08/0564Federal Ministry of Education & Research (BMBF)FKZ: da01KA0803Institut de Recherche pour le Developpement (IRD), FranceBill & Melinda Gates FoundationCGIARFrench National Research Agency (ANR)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)R21-HD060524Fondation de France00079816, ANR-10-PRSP-0012,TOLIMMUNPAL(2010), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université de Paris (UP), Université d’Abomey-Calavi (UAC), EHESP, SCD, and PROGRAMME DE RECHERCHE EN SANTE PUBLIQUE - - TOLIMMUNPAL2010 - ANR-10-PRSP-0012 - PRSP - VALID

Subjects
Male, Epidemiology, statistics & research methods, paediatrics, Cohort Studies, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Pregnancy, Benin, Humans, Prospective Studies, Child, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, public health, Body Weight, Infant, Newborn, Infant, Bayes Theorem, Body Height, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female
Abstract

International audience; Objective To select a growth model that best describes individual growth trajectories of children and to present some growth characteristics of this population.Settings Participants were selected from a prospective cohort conducted in three health centres (Allada, Sekou and Attogon) in a semirural region of Benin, sub-Saharan Africa.Participants Children aged 0 to 6 years were recruited in a cohort study with at least two valid height and weight measurements included (n=961).Primary and secondary outcome measures This study compared the goodness-of-fit of three structural growth models (Jenss-Bayley, Reed and a newly adapted version of the Gompertz growth model) on longitudinal weight and height growth data of boys and girls. The goodness-of-fit of the models was assessed using residual distribution over age and compared with the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). The best-fitting model allowed estimating mean weight and height growth trajectories, individual growth and growth velocities. Underweight, stunting and wasting were also estimated at age 6 years.Results The three models were able to fit well both weight and height data. The Jenss-Bayley model presented the best fit for weight and height, both in boys and girls. Mean height growth trajectories were identical in shape and direction for boys and girls while the mean weight growth curve of girls fell slightly below the curve of boys after neonatal life. Finally, 35%, 27.7% and 8% of boys; and 34%, 38.4% and 4% of girls were estimated to be underweight, wasted and stunted at age 6 years, respectively.Conclusion The growth parameters of the best-fitting Jenss-Bayley model can be used to describe growth trajectories and study their determinants.

Published
2020

46. PfEMP1 A-type ICAM-1-binding domains are not associated with cerebral Malaria in Beninese children

Author

Joste, V., Guillochon, E., Fraering, Jeremy, Vianou, B., Watier, L., Guemouri, Sayeh, Cot, Michel, Houze, S., Aubouy, Agnès, Faucher, J. F., Argy, N., Bertin, Gwladys, and NeuroCM Study Group

Subjects
dual receptor binding, ICAM-1-binding motif, var genes, parasitic diseases, cytoadherence, cerebral malaria
Abstract

PfEMP1 is the major antigen involved in Plasmodium falciparum-infected erythrocyte sequestration in cerebrovascular endothelium. While some PfEMP1 domains have been associated with clinical phenotypes of malaria, formal associations between the expression of a specific domain and the adhesion properties of clinical isolates are limited. In this context, 73 cerebral malaria (CM) and 98 uncomplicated malaria (UM) Beninese children were recruited. We attempted to correlate the cytoadherence phenotype of Plasmodium falciparum isolates with the clinical presentation and the expression of specific PfEMP1 domains. Cytoadherence level on Hbec-5i and CHO-ICAM-1 cell lines and var genes expression were measured. We also investigated the prevalence of the ICAM-1-binding amino acid motif and dual receptor-binding domains, described as a potential determinant of cerebral malaria pathophysiology. We finally evaluated IgG levels against PfEMP1 recombinant domains (CIDR alpha 1.4, DBL beta 3, and CIDR alpha 1.4-DBL beta 3). CM isolates displayed higher cytoadherence levels on both cell lines, and we found a correlation between CIDR alpha 1.4 DBL beta 1/3 domain expression and CHO-ICAM-1 cytoadherence level. Endothelial protein C receptor (EPCR)-binding domains were overexpressed in CM isolates compared to UM whereas no difference was found in ICAM-1-binding DBL beta 1/3 domain expression. Surprisingly, both CM and UM isolates expressed ICAM-1-binding motif and dual receptor-binding domains. There was no difference in IgG response against DBL beta 3 between CM and UM isolates expressing ICAM-1-binding DB4 beta/3 domain. It raises questions about the role of this motif in CM pathophysiology, and further studies are needed, especially on the role of DBL beta 1/3 without the ICAM-1-binding motif. IMPORTANCE Cerebral malaria pathophysiology remains unknown despite extensive research. PfEMP1 proteins have been identified as the main Plasmodium antigen involved in cerebrovascular endothelium sequestration, but it is unclear which var gene domain is involved in Plasmodium cytoadhesion. EPCR binding is a major determinant of cerebral malaria whereas the ICAM-1-binding role is still questioned. Our study confirmed the EPCR-binding role in CM pathophysiology with a major overexpression of EPCR-binding domains in CM isolates. In contrast, ICAM-1-binding involvement appears less obvious with A-type ICAM-1-binding and dual receptor-binding domain expression in both CM and UM isolates. We did not find any variations in ICAM-1-binding motif sequences in CM compared to UM isolates. UM and CM patients infected with isolates expressing the ICAM-1-binding motif displayed similar IgG levels against DBL beta 3 recombinant protein. Our study raises interrogations about the role of these domains in CM physiopathology and questions their use in vaccine strategies against cerebral malaria.

Published
2020

47. Counter-selection of antimalarial resistance polymorphisms by intermittent preventive treatment in pregnancy

Author

Huijben, S., Macete, E., Mombo-Ngoma, G., Ramharter, M., Kariuki, S., Desai, M., Shi, Y. P., Mwangoka, G., Massougbodji, A., Cot, Michel, Tuikue Ndam, Nicaise, Uberegui, E., Gupta, H., Cistero, P., Aponte, J. J., Gonzalez, R., Menendez, C., and Mayor, A.

Subjects
pfmdr, parasitic diseases, mefloquine, malaria, intermittent preventive therapy, pregnancy
Abstract

Background. Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions. Methods. Plasmodium fakiparum isolates (n = 914) from 2 randomized clinical trials were screened for pfmdrl copy number variation and pfcrt, pfmdrl, pfdhfr, and pfdhps resistance markers. The trials were conducted between 2010 and 2013 in Benin, Gabon, Kenya, and Mozambique to establish the efficacy of IPTp-mefloquine (MQ) compared with IPTp-sulphadoxine-pyrimethamine (SP) in human immunodeficiency virus (HIV)-uninfected and to IPTp-placebo in HIV-infected women. Results. In HIV-uninfected women, the prevalence of pfcrt mutants, pfdhfr/pfdhps quintuple mutants, and pfmdrl copy number was similar between women receiving IPT-SP and IPTp-MQ. However, prevalence of pfmdr1 polymorphism 86Y was lower in the IPTp-MQ group than in the IPTp-SP group, and within the IPTp-MQ group it was lower at delivery compared with recruitment. No effect of IPTp-MQ on resistance markers was observed among HIV-infected women. The carriage of resistance markers was not associated with pregnancy outcomes. Conclusions. Selection of wild-type pfmdrl polymorphism N86 by IPTp-MQ highlights the strong selective pressure IPTp can exert and the opportunity for using negative cross-resistance in drug choice for clinical treatment and IPTp.

Published
2020

50. Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis.

Author

The WorldWide Antimalarial Resistance Network Methodology Study Group, Dahal, Prabin, Simpson, Julie Anne, Abdulla, Salim, Achan, Jane, Adam, Ishag, Agarwal, Aarti, Allan, Richard, Anvikar, Anupkumar R., Arinaitwe, Emmanuel, Ashley, Elizabeth A., Awab, Ghulam Rahim, Bassat, Quique, Björkman, Anders, Borrmann, Steffen, Bousema, Teun, Bukirwa, Hasifa, Carrara, Verena I., Corsi, Marco, and Cot, Michel

Subjects
PLASMODIUM falciparum, DISEASE relapse, TREATMENT failure, DRUG resistance, TREATMENT effectiveness
Abstract

Background: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria. Methods: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites. Fractional polynomials were used to capture non-linear instantaneous hazard. The area under the density curve (AUC) of the constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify the absolute overestimation in efficacy due to sub-optimal follow-up. Results: Overall, 3703 recurrent infections were detected in 60 studies conducted in Africa (15,512 children aged < 5 years) and 23 studies conducted in Asia and South America (5272 patients of all ages). Using molecular genotyping, 519 (14.0%) recurrences were ascribed as recrudescent infections. A 28 day artemether-lumefantrine (AL) efficacy trial would not have detected 58% [95% confidence interval (CI) 47–74%] of recrudescences in African children and 32% [95% CI 15–45%] in patients of all ages in Asia/South America. The corresponding estimate following a 42 day dihydroartemisinin-piperaquine (DP) efficacy trial in Africa was 47% [95% CI 19–90%] in children under 5 years old treated with > 48 mg/kg total piperaquine (PIP) dose and 9% [95% CI 0–22%] in those treated with ≤ 48 mg/kg PIP dose. In absolute terms, the simulation study found that trials limited to 28 days follow-up following AL underestimated the risk of recrudescence by a median of 2.8 percentage points compared to day 63 estimates and those limited to 42 days following DP underestimated the risk of recrudescence by a median of 2.0 percentage points compared to day 42 estimates. The analysis was limited by few clinical trials following patients for longer than 42 days (9 out of 83 trials) and the imprecision of PCR genotyping which overcalls recrudescence in areas of higher transmission biasing the later distribution. Conclusions: Restricting follow-up of clinical efficacy trials to day 28 for AL and day 42 for DP will miss a proportion of late recrudescent treatment failures but will have a modest impact in derived efficacy. The results highlight that as genotyping methods improve consideration should be given for trials with longer duration of follow-up to detect early indications of emerging drug resistance. [ABSTRACT FROM AUTHOR]

Published
2022
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