331 results on '"Costes N"'
Search Results
2. 18F‐NaF PET‐MRI: an innovative tool to assess carotid artery plaque vulnerability
- Author
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Mechtouff, L., Sigovan, M., Costes, N., Douek, P., Collet‐Benzaquen, D., Nighoghossian, N., and Berthezene, Y.
- Published
- 2018
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3. Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI
- Author
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Yankam Njiwa, J, Costes, N, Bouillot, C, Bouvard, S, Fieux, S, Becker, G, Levigoureux, E, Kocevar, G, Stamile, C, Langlois, JB, Bolbos, R, Bonnet, C, Bezin, L, Zimmer, L, and Hammers, A
- Published
- 2017
- Full Text
- View/download PDF
4. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016
- Author
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Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Ranzani, O. T., Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Torres, A., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Pesenti, A., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Ince, C., Uz, Z., Massey, M., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Toraman, F., Ince, C., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. J., Ista, E., Krajčová, A., Waldauf, P., Duška, F., Shah, A., Roy, N., McKechnie, S., Doree, C., Fisher, S., Stanworth, S. J., Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F., Egerod, I., Pivkina, A., Gusarov, V., Zhivotneva, I., Pasko, N., Zamyatin, M., Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Alklit, A., Hansen, R. L., Knudsen, H., Grode, L. B., Overgaard, D., Hravnak, M., Chen, L., Dubrawski, A., Clermont, G., Pinsky, M. R., Parry, S. M., Knight, L. D., Connolly, B. C., Baldwin, C. E., Puthucheary, Z. A., Denehy, L., Hart, N., Morris, P. E., Mortimore, J., Granger, C. L., Jensen, H. I., Piers, R., Van den Bulcke, B., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Van den Bulcke, B., Piers, R., Jensen, H. I., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Ryan, C., Dawson, D., Ball, J., Noone, K., Aisling, B., Prudden, S., Ntantana, A., Matamis, D., Savvidou, S., Giannakou, M., Gouva, M., Nakos, G., Koulouras, V., Aron, J., Lumley, G., Milliken, D., Dhadwal, K., McGrath, B. A., Lynch, S. J., Bovento, B., Sharpe, G., Grainger, E., Pieri-Davies, S., Wallace, S., McGrath, B., Lynch, S. J., Bovento, B., Grainger, E., Pieri-Davies, S., Sharpe, G., Wallace, S., Jung, M., Cho, J., Park, H., Suh, G., Kousha, O., Paddle, J., Gripenberg, L. Gamrin, Rehal, M. Sundström, Wernerman, J., Rooyackers, O., de Grooth, H. J., Choo, W. P., Spoelstra-de Man, A. M., Swart, E. L., Oudemans-van Straaten, H. M., Talan, L., Güven, G., Altıntas, N. D., Padar, M., Uusvel, G., Starkopf, L., Starkopf, J., Blaser, A. Reintam, Kalaiselvan, M. S., Arunkumar, A. S., Renuka, M. K., Shivkumar, R. L., Volbeda, M., ten Kate, D., Hoekstra, M., van der Maaten, J. M., Nijsten, M. W., Komaromi, A., Rooyackers, O., Wernerman, J., Norberg, Å., Smedberg, M., Mori, M., Pettersson, L., Norberg, Å., Rooyackers, O., Wernerman, J., Theodorakopoulou, M., Christodoulopoulou, T., Diamantakis, A., Frantzeskaki, F., Kontogiorgi, M., Chrysanthopoulou, E., Lygnos, M., Diakaki, C., Armaganidis, A., Gundogan, K., Dogan, E., Coskun, R., Muhtaroglu, S., Sungur, M., Ziegler, T., Guven, M., Kleyman, A., Khaliq, W., Andreas, D., Singer, M., Meierhans, R., Schuepbach, R., De Brito-Ashurst, I., Zand, F., Sabetian, G., Nikandish, R., Hagar, F., Masjedi, M., Maghsudi, B., Vazin, A., Ghorbani, M., Asadpour, E., Kao, K. C., Chiu, L. C., Hung, C. Y., Chang, C. H., Li, S. H., Hu, H. C., El Maraghi, S., Ali, M., Rageb, D., Helmy, M., Marin-Corral, J., Vilà, C., Masclans, J. R., Vàzquez, A., Martín-Loeches, I., Díaz, E., Yébenes, J. C., Rodriguez, A., Álvarez-Lerma, F., Varga, N., Cortina-Gutiérrez, A., Dono, L., Martínez-Martínez, M., Maldonado, C., Papiol, E., Pérez-Carrasco, M., Ferrer, R., Nweze, K., Morton, B., Welters, I., Houard, M., Voisin, B., Ledoux, G., Six, S., Jaillette, E., Nseir, S., Romdhani, S., Bouneb, R., Loghmari, D., Aicha, N. Ben, Ayachi, J., Meddeb, K., Chouchène, I., Khedher, A., Boussarsar, M., Chan, K. S., Yu, W. L., Marin-Corral, J., Vilà, C., Masclans, J. R., Nolla, J., Vidaur, L., Bonastre, J., Suberbiola, B., Guerrero, J. E., Rodriguez, A., Coll, N. Ramon, Jiménez, G. Jiménez, Brugger, S. Carvalho, Calero, J. Codina, Garrido, B. Balsera, García, M., Martínez, M. Palomar, Vidal, M. Vallverdú, de la Torre, M. C., Vendrell, E., Palomera, E., Güell, E., Yébenes, J. C., Serra-Prat, M., Bermejo-Martín, J. F., Almirall, J., Tomas, E., Escoval, A., Froe, F., Pereira, M. H. Vitoria, Velez, N., Viegas, E., Filipe, E., Groves, C., Reay, M., Chiu, L. C., Hu, H. C., Hung, C. Y., Chang, C. H., Li, S. H., Kao, K. C., Ballin, A., Facchin, F., Sartori, G., Zarantonello, F., Campello, E., Radu, C. M., Rossi, S., Ori, C., Simioni, P., Umei, N., Shingo, I., Santos, A. C., Candeias, C., Moniz, I., Marçal, R., e Silva, Z. Costa, Ribeiro, J. M., Georger, J. F., Ponthus, J. P., Tchir, M., Amilien, V., Ayoub, M., Barsam, E., Martucci, G., Panarello, G., Tuzzolino, F., Capitanio, G., Ferrazza, V., Carollo, T., Giovanni, L., Arcadipane, A., Sánchez, M. López, González-Gay, M. A., Díaz, F. J. Llorca, López, M. I. Rubio, Zogheib, E., Villeret, L., Nader, J., Bernasinski, M., Besserve, P., Caus, T., Dupont, H., Morimont, P., Habran, S., Hubert, R., Desaive, T., Blaffart, F., Janssen, N., Guiot, J., Pironet, A., Dauby, P., Lambermont, B., Zarantonello, F., Ballin, A., Facchin, F., Sartori, G., Campello, E., Pettenuzzo, T., Citton, G., Rossi, S., Simioni, P., Ori, C., Kirakli, C., Ediboglu, O., Ataman, S., Yarici, M., Tuksavul, F., Keating, S., Gibson, A., Gilles, M., Dunn, M., Price, G., Young, N., Remeta, P., Bishop, P., Zamora, M. D. Fernández, Muñoz-Bono, J., Curiel-Balsera, E., Aguilar-Alonso, E., Hinojosa, R., Gordillo-Brenes, A., Arboleda-Sánchez, J. A., Skorniakov, I., Vikulova, D., Whiteley, C., Shaikh, O., Jones, A., Ostermann, M., Forni, L., Scott, M., Sahatjian, J., Linde-Zwirble, W., Hansell, D., Laoveeravat, P., Srisawat, N., Kongwibulwut, M., Peerapornrattana, S., Suwachittanont, N., Wirotwan, T. O., Chatkaew, P., Saeyub, P., Latthaprecha, K., Tiranathanagul, K., Eiam-ong, S., Kellum, J. A., Berthelsen, R. E., Perner, A., Jensen, A. E. K., Jensen, J. U., Bestle, M. H., Gebhard, D. J., Price, J., Kennedy, C. E., Akcan-Arikan, A., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Kang, Y. R., Nakamae, M. N., Koh, I. H. J., Hamed, K., Khaled, M. M., Soliman, R. Aly, Mokhtar, M. Sherif, Seller-Pérez, G., Arias-Verdú, D., Llopar-Valdor, E., De-Diós-Chacón, I., Quesada-García, G., Herrera-Gutierrez, M. E., Hafes, R., Carroll, G., Doherty, P., Wright, C., Vera, I. G. Guerra, Ralston, M., Gemmell, M. L., MacKay, A., Black, E., Wright, C., Docking, R. I., Appleton, R., Ralston, M. R., Gemmell, L., Appleton, R., Wright, C., Docking, R. I., Black, E., Mackay, A., Rozemeijer, S., Mulier, J. L. G. Haitsma, Röttgering, J. G., Elbers, P. W. G., Spoelstra-de Man, A. M. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Mejeni, N., Nsiala, J., Kilembe, A., Akilimali, P., Thomas, G., Egerod, I., Andersson, A. E., Fagerdahl, A. M., Knudsen, V., Meddeb, K., Cheikh, A. Ben, Hamdaoui, Y., Ayachi, J., Guiga, A., Fraj, N., Romdhani, S., Sma, N., Bouneb, R., Chouchene, I., Khedher, A., Bouafia, N., Boussarsar, M., Amirian, A., Ziaian, B., Masjedi, M., Fleischmann, C., Thomas-Rueddel, D. O., Schettler, A., Schwarzkopf, D., Stacke, A., Reinhart, K., Filipe, E., Escoval, A., Martins, A., Sousa, P., Velez, N., Viegas, E., Tomas, E., Snell, G., Matsa, R., Paary, T. T. S., Kalaiselvan, M. S., Cavalheiro, A. M., Rocha, L. L., Vallone, C. S., Tonilo, A., Lobato, M. D. S., Malheiro, D. T., Sussumo, G., Lucino, N. M., Zand, F., Rosenthal, V. D., Masjedi, M., Sabetian, G., Maghsudi, B., Ghorbani, M., Dashti, A. Sanaei, Yousefipour, A., Goodall, J. R., Williamson, M., Tant, E., Thomas, N., Balci, C., Gonen, C., Haftacı, E., Gurarda, H., Karaca, E., Paldusová, B., Zýková, I., Šímová, D., Houston, S., D’Antona, L., Lloyd, J., Garnelo-Rey, V., Sosic, M., Sotosek-Tokmazic, V., Kuharic, J., Antoncic, I., Dunatov, S., Sustic, A., Chong, C. T., Sim, M., Lyovarin, T., Díaz, F. M. Acosta, Galdó, S. Narbona, Garach, M. Muñoz, Romero, O. Moreno, Bailón, A. M. Pérez, Pinel, A. Carranza, Colmenero, M., Gritsan, A., Gazenkampf, A., Korchagin, E., Dovbish, N., Lee, R. M., Lim, M. P. P., Chong, C. T., Lim, B. C. L., See, J. J., Assis, R., Filipe, F., Lopes, N., Pessoa, L., Pereira, T., Catorze, N., Aydogan, M. S., Aldasoro, C., Marchio, P., Jorda, A., Mauricio, M. D., Guerra-Ojeda, S., Gimeno-Raga, M., Colque-Cano, M., Bertomeu-Artecero, A., Aldasoro, M., Valles, S. L., Tonon, D., Triglia, T., Martin, J. C., Alessi, M. C., Bruder, N., Garrigue, P., Velly, L., Spina, S., Scaravilli, V., Marzorati, C., Colombo, E., Savo, D., Vargiolu, A., Cavenaghi, G., Citerio, G., Andrade, A. H. V., Bulgarelli, P., Araujo, J. A. P., Gonzalez, V., Souza, V. A., Costa, A., Massant, C., Filho, C. A. C. Abreu, Morbeck, R. A., Burgo, L. E., van Groenendael, R., van Eijk, L. T., Leijte, G. P., Koeneman, B., Kox, M., Pickkers, P., García-de la Torre, A., de la Torre-Prados, M., Fernández-Porcel, A., Rueda-Molina, C., Nuevo-Ortega, P., Tsvetanova-Spasova, T., Cámara-Sola, E., García-Alcántara, A., Salido-Díaz, L., Liao, X., Feng, T., Zhang, J., Cao, X., Wu, Q., Xie, Z., Li, H., Kang, Y., Winkler, M. S., Nierhaus, A., Mudersbach, E., Bauer, A., Robbe, L., Zahrte, C., Schwedhelm, E., Kluge, S., Zöllner, C., Morton, B., Mitsi, E., Pennington, S. H., Reine, J., Wright, A. D., Parker, R., Welters, I. D., Blakey, J. D., Rajam, G., Ades, E. W., Ferreira, D. M., Wang, D., Kadioglu, A., Gordon, S. B., Koch, R., Kox, M., Rahamat-Langedoen, J., Schloesser, J., de Jonge, M., Pickkers, P., Bringue, J., Guillamat-Prats, R., Torrents, E., Martinez, M. L., Camprubí-Rimblas, M., Artigas, A., Blanch, L., Park, S. Y., Park, Y. B., Song, D. K., Shrestha, S., Park, S. H., Koh, Y., Park, M. J., Hong, C. W., Lesur, O., Coquerel, D., Sainsily, X., Cote, J., Söllradl, T., Murza, A., Dumont, L., Dumaine, R., Grandbois, M., Sarret, P., Marsault, E., Salvail, D., Auger-Messier, M., Chagnon, F., Lauretta, M. P., Greco, E., Dyson, A., Singer, M., Preau, S., Ambler, M., Sigurta, A., Saeed, S., Singer, M., Sarıca, L. Topcu, Zibandeh, N., Genc, D., Gul, F., Akkoc, T., Kombak, E., Cinel, L., Akkoc, T., Cinel, I., Pollen, S. J., Arulkumaran, N., Singer, M., Torrance, H. D., Longbottom, E. R., Warnes, G., Hinds, C. J., Pennington, D. J., Brohi, K., O’Dwyer, M. J., Kim, H. Y., Na, S., Kim, J., Chang, Y. F., Chao, A., Shih, P. Y., Lee, C. T., Yeh, Y. C., Chen, L. W., Adriaanse, M., Trogrlic, Z., Ista, E., Lingsma, H., Rietdijk, W., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., Gommers, D. A. M. P. J., van der Jagt, M., Funcke, S., Sauerlaender, S., Saugel, B., Pinnschmidt, H., Reuter, D. A., Nitzschke, R., Perbet, S., Biboulet, C., Lenoire, A., Bourdeaux, D., Pereira, B., Plaud, B., Bazin, J. E., Sautou, V., Mebazaa, A., Constantin, J. M., Legrand, M., Boyko, Y., Jennum, P., Nikolic, M., Oerding, H., Holst, R., Toft, P., Nedergaard, H. K., Haberlandt, T., Jensen, H. I., Toft, P., Park, S., Kim, S., Cho, Y. J., Lim, Y. J., Chan, A., Tang, S., Nunes, S. L., Forsberg, S., Blomqvist, H., Berggren, L., Sörberg, M., Sarapohja, T., Wickerts, C. J., Hofhuis, J. G. M., Rose, L., Blackwood, B., Akerman, E., Mcgaughey, J., Egerod, I., Fossum, M., Foss, H., Georgiou, E., Graff, H. J., Kalafati, M., Sperlinga, R., Schafer, A., Wojnicka, A. G., Spronk, P. 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Redondo, Bejarano, N., Baladron, V., Villazala, R., Redondo, J., Padilla, D., Villarejo, P., Akcan-Arikan, A., Kennedy, C. E., Arzapalo, M. F. Aguilar, Gomez-Gonzalez, C., Mas-Font, S., Puppo-Moreno, A., Herrera-Gutierrez, M., Garcia-Garcia, M., Aldunate-Calvo, S., Plata-Menchaca, E. P., Pérez-Fernández, X. L., Estruch, M., Betbese-Roig, A., Campos, P. Cárdenas, Lora, M. Rojas, Gaibor, N. D. Toapanta, Medina, R. S. Contreras, Sanguino, V. D. Gumucio, Casanova, E. J., Riera, J. Sabater, Kritmetapak, K., Peerapornratana, S., Kittiskulnam, P., Dissayabutra, T., Tiranathanagul, K., Susantithapong, P., Praditpornsilpa, K., Tungsanga, K., Eiam-Ong, S., Srisawat, N., Winkelmann, T., Busch, T., Meixensberger, J., Bercker, S., Cabeza, E. M. Flores, Sánchez, M. Sánchez, Giménez, N. Cáceres, Melón, C. Gutierrez, de Lucas, E. Herrero, Estañ, P. Millán, Bernal, M. Hernández, de Lorenzo y Mateos, A. Garcia, Ergin, B., Guerci, P., Specht, P. A. C., Ince, Y., Ince, C., Balik, M., Zakharchenko, M., Los, F., Brodska, H., de Tymowski, C., Augustin, P., Desmard, M., Montravers, P., Stapel, S. N., de Boer, R., Oudemans, H. M., Hollinger, A., Schweingruber, T., Jockers, F., Dickenmann, M., Siegemund, M., Runciman, N., Ralston, M., Appleton, R., Mauri, T., Alban, L., Turrini, C., Sasso, T., Langer, T., Panigada, M., Taccone, P., Carlesso, E., Marenghi, C., Grasselli, G., Pesenti, A., Wibart, P., Reginault, T., Garcia, M., Barbrel, B., Benard, A., Bader, C., Vargas, F., Bui, H. N., Hilbert, G., Simón, J. M. Serrano, Sánchez, P. Carmona, Ferrón, F. Ruiz, de Acilu, M. García, Marin, J., Antonia, V., Ruano, L., Monica, M., Ferrer, R., Masclans, J. R., Roca, O., Hong, G., Kim, D. H., Kim, Y. S., Park, J. S., Jee, Y. K., xiang, Z. Yu, Jia-xing, W., dan, W. Xiao, long, N. Wen, Yu, W., Yan, Z., Cheng, X., Kobayashi, T., Onodera, Y., Akimoto, R., Sugiura, A., Suzuki, H., Iwabuchi, M., Nakane, M., Kawamae, K., Sanchez, P. Carmona, Rodriguez, M. D. Bautista, Delgado, M. Rodriguez, Sánchez, V. Martínez de Pinillos, Gómez, A. Mula, Simón, J. M. Serrano, Beuret, P., Fortes, C., Lauer, M., Reboul, M., Chakarian, J. C., Fabre, X., Philippon-Jouve, B., Devillez, S., Clerc, M., Rittayamai, N., Sklar, M., Dres, M., Rauseo, M., Campbell, C., West, B., Tullis, D. E., Brochard, L., Onodera, Y., Akimoto, R., Suzuki, H., Okada, M., Nakane, M., Kawamae, K., Ahmad, N., Wood, M., Glossop, A., Lucas, J. Higuera, Ortiz, A. Blandino, Alonso, D. Cabestrero, De Pablo Sánchez, R., González, L. Rey, Costa, R., Spinazzola, G., Pizza, A., Ferrone, G., Rossi, M., Antonelli, M., Conti, G., Ribeiro, H., Alves, J., Sousa, M., Reis, P., Socolovsky, C. S., Cauley, R. P., Frankel, J. E., Beam, A. L., Olaniran, K. O., Gibbons, F. K., Christopher, K. B., Pennington, J., Zolfaghari, P., King, H. S., Kong, H. H. Y., Shum, H. P., Yan, W. W., Kaymak, C., Okumus, N., Sari, A., Erdogdu, B., Aksun, S., Basar, H., Ozcan, A., Ozcan, N., Oztuna, D., Malmgren, J. A., Lundin, S., Torén, K., Eckerström, M., Wallin, A., Waldenström, A. C., Riccio, F. C., Pogson, D., Antonio, A. C. P., Leivas, A. F., Kenji, F., James, E., Morgan, P., Carroll, G., Gemmell, L., MacKay, A., Wright, C., Ballantyne, J., Jonnada, S., Gerrard, C. S., Jones, N., Salciccioli, J. D., Marshall, D. C., Komorowski, M., Hartley, A., Sykes, M. C., Goodson, R., Shalhoub, J., Villanueva, J. R. Fernández, Garda, R. Fernández, Lago, A. M. López, Ruiz, E. Rodríguez, Vaquero, R. Hernández, Rodríguez, C. Galbán, Pérez, E. Varo, Hilasque, C., Oliva, I., Sirgo, G., Martin, M. C., Olona, M., Gilavert, M. C., Bodí, M., Ebm, C., Aggarwal, G., Huddart, S., Quiney, N., Cecconi, M., Fernandes, S. M., Silva, J. Santos, Gouveia, J., Silva, D., Marques, R., Bento, H., Alvarez, A., Silva, Z. Costa, Diaz, D. Díaz, Martínez, M. Villanova, Herrejon, E. Palencia, de la Gandara, A. Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.
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- 2016
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5. A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease
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Truchot, L., Costes, N., Zimmer, L., Laurent, B., Le Bars, D., Thomas-Antérion, C., Mercier, B., Hermier, M., Vighetto, A., and Krolak-Salmon, P.
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- 2008
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6. Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson’s disease: A[11C]-raclopride PETstudy
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Thobois, S., Fraix, V., Savasta, M., Costes, N., Pollak, P., Mertens, P., Koudsie, A., Le Bars, D., Benabid, A. L., and Broussolle, E.
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- 2003
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7. Chronic subthalamic nucleus stimulation and striatal D2 dopamine receptors in Parkinson's disease; A [[.sup.11]C]-raclopride PET study
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Thobois, S., Fraix, V., Savasta, M., Costes, N., Pollak, P., Mertens, P., Koudsie, A., Bars, D., Benabid, A. L., and Broussolle, E.
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Thalamus -- Research ,Dopamine -- Dosage and administration ,PET imaging -- Usage ,Brain stimulation -- Usage ,Health - Abstract
Byline: S. Thobois (1,3), V. Fraix (2,5), M. Savasta (5), N. Costes (3), P. Pollak (2,5), P. Mertens (4), A. Koudsie (2), D. Bars (3), A. L. Benabid (2,5), E. Broussolle (1,3) Keywords: Parkinson's disease; subthalamic stimulation; dopamine; raclopride; PET Abstract: Abstract. Context: Subthalamic nucleus (STN) stimulation mechanism of action remains a matter for debate. In animals, an increased striatal dopamine (DA) release due to STN stimulation has been reported. Objective: To determine in Parkinson's disease (PD) patients using positron emission tomography (PET) and [[.sup.11]C]-Raclopride, whether STN stimulation induces a striatal DA release. Methods: Nine PD patients with bilateral STN stimulation were enrolled and underwent two [[.sup.11]C]-Raclopride PET scans. The scans were randomly performed in off and on stimulation conditions. Striatal [[.sup.11]C]-Raclopride binding potential (BP) was calculated using regions of interest and statistical parametric mapping. Results: For PD patients, the mean [[.sup.11]C]-Raclopride BP (+- SD) were, in Off stimulation condition: 1.7 +- 0.3 for the right caudate nucleus, 1.8 +- 0.4 for the left caudate nucleus, 2.6 +- 0.5 for the right putamenand 2.6 +- 0.5 for the left putamen. In On stimulation condition: 1.7 +- 0.4 for the right caudate nucleus, 1.9 +- 0.5 for the left caudate nucleus, 2.8 +- 0.7 for the right putamen and 2.7 +- 0.8 for the left putamen. No significant difference of BP related to the stimulation was noted. Conclusion: STN stimulation does not produce significant variations of striatal DA release as assessed by PET and [[.sup.11]C]-Raclopride. Author Affiliation: (1) Dept. of Neurology D (Pr. G. Chazot) and INSERM U 534, Hopital Neurologique Pierre Wertheimer, 59 Bd Pinel, 69003, Lyon, France (2) Dept. of Neurology and Neurosurgery, CHU, Grenoble, France (3) CERMEP, Cyclotron Unit, Lyon, France (4) Dept. of Neurosurgery A (Pr. M. Sindou), Hopital Neurologique Pierre Wertheimer, Lyon, France (5) INSERM U 318, CHU, Grenoble, France Article History: Received Date: 24/01/2003 Accepted Date: 02/06/2003
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- 2003
8. Monte Carlo simulation-based design study of a LSO-LuAP small animal PET system
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Lartizien, C., Reilhac, A., Costes, N., Janier, M., and Sappey-Marinier, D.
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PET imaging -- Research ,Business ,Electronics ,Electronics and electrical industries - Abstract
Positron emission tomography (PET) scanners dedicated to small animal imaging should combine very high sensitivity (>2%) and resolution (1.6%) while keeping good spatial resolution (3-4 mm at the extremity of the field-of-view) thanks to the DOI capability. Index Terms--DOI, Monte Carlo simulation, small animal positron emission tomography (PET).
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- 2003
9. TOWARDS PREDICTING INDIVIDUAL OUTCOME IN PATIENTS AFTER TEMPORAL LOBE SURGERY FOR HIPPOCAMPAL SCLEROSIS: WHITE MATTER FDG AND [11C]FLUMAZENIL BINDING: p475
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Njiwa, Yankam J., Bouvard, S., Costes, N., Catenoix, H., Ryvlin, P., and Hammers, A.
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- 2012
10. Partial RhC Antigen in Sickle Cell Disease Patients: Clinical Relevance and Prevention: S35-020C
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Noizat-Pirenne, F, Meunier-Costes, N, Costes, B, Martret, J, Barrault, A, Galacteros, F, Bierling, P, and Tournamille, C
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- 2009
11. The ClearPET™ project: development of a 2nd generation high-performance small animal PET scanner
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Ziemons, K., E. Auffray, Barbier, R., Brandenburg, G., Bruyndonckx, P., Choi, Y., Christ, D., Costes, N., Declais, Y., Devroede, O., Dujardin, C., Fedorovd, A., Heinrichs, U., Korjik, M., Krieguer, M., Kuntner, C., Largeron, G., Lartizien, C., Larue, H., Lecoq, P., Leonard, S., Marteau, J., Morel, Ch., Mosset, J.B., Parl, Ch., Pedrini, Ch., Petrosyan, A.G., Pietrzyk, U., Rey, M., Saladino, S., Sappey-Marinier, D., Simon, L., Streun, M., Tavernier, S., and Vieira, J.M.
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- 2005
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12. Interictal brain 5-HT1A receptors binding in migraine without aura: a 18F-MPPF-PET study
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Lothe, A, Merlet, I, Demarquay, G, Costes, N, Ryvlin, P, and Mauguière, F
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- 2008
13. Hyper reactivity to stress in unaffected siblings of patients with schizophrenia: OR023.
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Brunelin, J, Dʼamato, T, Costes, N, Dalery, J, and Saoud, M
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- 2008
14. Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study
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Lothe, A., Didelot, A., Hammers, A., Costes, N., Saoud, M., Gilliam, F., and Ryvlin, P.
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- 2008
15. MOTOR CORTEX STIMULATION FOR PAIN CONTROL INDUCES METABOLIC CHANGES IN THE ENDOGENOUS OPIOID SYSTEM: 462
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Maarrawi, J., Mertens, P., Peyron, R., Costes, N., Sindou, M., Laurent, B., and Garcia-Larrea, L.
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- 2006
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16. Spacecraft Disposal on a Graveyard Orbit: The In-Flight AOCS Performance for Eurostar 2000 and SPOT 1 during End-of-Life Operations
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Mignon, D., Costes, N., Reuilh, A., Gonnaud, J.-L., Horblin, M., and Jallade, S.
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- 2004
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17. Apollo 11 Soil Mechanics Investigation
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Costes, N. C., Carrier, W. D., Mitchell, J. K., and Scott, R. F.
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- 1970
18. Analysis of coolant flow and heat transfer in the SSME HPOTP Number 4 bearing assembly
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Owens, S. F and Costes, N. C
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Spacecraft Propulsion And Power - Abstract
The PHOENICS code has been applied to simulate the flow of liquid oxygen through the number 4 ball bearing assembly of the Space Shuttle Main Engine High-Pressure Oxidizer Turbopump. The Body-Fitted Coordinate system capability of PHOENICS was utilized to create a geometrically accurate model. Effects accounted for by the model include the rotation rate of the calculation domain, viscous heating in the liquid oxygen and two-phase effects due to LOX boiling. A separation program was used to account for conduction within a ball bearing element which was coupled with the PHOENICS flow and heat transfer analysis. Solutions have been obtained for the velocity and temperature fields within the LOX coolant and the temperature within the ball element. The predicted ball temperatures indicate that the coolant is boiling in the region near the ball surface.
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- 1990
19. Exploration of the concept of 5-HT1A receptor biased agonists: a multimodal imaging study
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Vidal, B., primary, Fieux, S., additional, Redouté, J., additional, Villien, M., additional, Le Bars, D., additional, Newman-Tancredi, A., additional, Costes, N., additional, and Zimmer, L., additional
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- 2017
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20. 5-HT1A biased agonists induce different hemodynamic responses: a pharmacological MRI study
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Vidal, B., primary, Bolbos, R., additional, Redouté, J., additional, Langlois, J.B., additional, Fieux, S., additional, Bouillot, C., additional, Costes, N., additional, Newman-Tancredi, A., additional, and Zimmer, L., additional
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- 2017
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21. Impact du contenu en AGE sur l’hyperfiltration glomérulaire induite par les protéines
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Normand, G., primary, Lemoine, S., additional, Villien, M., additional, Lebars, D., additional, Merida, I., additional, Irace, Z., additional, Costes, N., additional, and Juillard, L., additional
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- 2017
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22. Online transcranial direct current stimulation of the frontal cortex induces dopamine release in the striatum – a spatial and temporal analysis in healthy humans
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Fonteneau, C., primary, Haesebaert, F., additional, Redoute, J., additional, Le Bars, D., additional, Costes, N., additional, Brunelin, J., additional, and Suaud-Chagny, M.F., additional
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- 2017
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23. Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI
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Yankam Njiwa, J, primary, Costes, N, additional, Bouillot, C, additional, Bouvard, S, additional, Fieux, S, additional, Becker, G, additional, Levigoureux, E, additional, Kocevar, G, additional, Stamile, C, additional, Langlois, JB, additional, Bolbos, R, additional, Bonnet, C, additional, Bezin, L, additional, Zimmer, L, additional, and Hammers, A, additional
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- 2016
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24. Selective serotonin 5-HT1A receptor biased agonists elicitdistinct brain activation patterns: a pharmacoMRI study
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Becker, G., primary, Bolbos, R., additional, Costes, N., additional, Redouté, J., additional, Newman-Tancredi, A., additional, and Zimmer, L., additional
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- 2016
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25. The human hippocampus and amygdala: Probabilistic atlases in a stereotaxic space, and quantitative comparison of spatial normalization strategies
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Vial, C., Belgacem, M., Heckemann, R. A., Yankam Njiwa, J., Allom, R., Chen, C.H., Costes, N., Hammers, A., Division of Experimental Medicine, Imperial College London, Fondation neurodis, Fondation Neurodis, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
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[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Published
- 2013
26. Supervised clustering for determining a reference region for [11C]PK11195 PET: Adaptation to rat PET studies
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Costes , N., Blanc , C., Bouillot , C., Yankam Njiwa , J., Bolbos , R., Bouvard , S., Chauveau , F., Le Bars , D., Turkheimer , F. E., Hammers , A., Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Translational and integrative group in epilepsy research, Lyon Neuroscience Research center, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Division of Experimental Medicine, Imperial College London, Fondation neurodis, Fondation Neurodis, Centre d'Exploration et de Recherche Médicales par Émission de Positons ( CERMEP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon ( HCL ) -CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Hospices Civils de Lyon ( HCL ) -Université Jean Monnet [Saint-Étienne] ( UJM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Chimie et Biochimie Moléculaires et Supramoléculaires ( ICBMS ), and Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique ( CNRS )
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[ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Published
- 2013
27. Backtranslating MRI-PET joint analyses to rats: Supervised clustering for reference region extraction for [11C]PK11195 PET
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Costes, N., Blanc, C., Bouillot, C., Yankam Njiwa, J., Bolbos, R., Bouvard, S., Chauveau, F., Le Bars, D., Turkheimer, F. E., Hammers, A., Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Translational and integrative group in epilepsy research, Lyon Neuroscience Research center, Centre de recherche en neurosciences de Lyon (CRNL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Division of Experimental Medicine, Imperial College London, Clinical Sciences Centre, Medical Research Council, Centre for Neuroimaging Sciences, Institute of Psychiatry, King‘s College London, Fondation neurodis, and Fondation Neurodis
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[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2013
28. A multi-atlas based method for automated anatomical rat brain MRI segmentation and extraction of PET kinetics
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Lancelot, S., Hammers, A., Langlois, J.-B., Bouillot, C., Zimmer, L., Costes, N., Radiopharmaceutical and Neurochemical Biomarkers Team (BioRaN), Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Fondation neurodis, Fondation Neurodis, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
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ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2012
29. Test-retest reliability of [11C]flumazenil data acquired using the Delforge partial saturation method
- Author
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Bouvard, S., Costes, N., Bonnefoi, F., Lavenne, F., Mauguière, F., Ryvlin, P., Hammers, A., Translational and integrative group in epilepsy research, Lyon Neuroscience Research center, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), The Neurodis Fondation, Neurodis, Division of Experimental Medicine, Imperial College London, Fondation neurodis, and Fondation Neurodis
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ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2012
30. Towards predicting individual outcome in patients after temporal lobe surgery for hippocampal sclerosis: White matter FDG and [11C]flumazenil binding
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Yankam Njiwa, J., Bouvard, S., Costes, N., Catenoix, H., Ryvlin, P., Hammers, A., Fondation neurodis, Fondation Neurodis, Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Cerebrovascular Unit [Lyon], Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL], Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Translational and integrative group in epilepsy research, and Lyon Neuroscience Research center
- Abstract
International audience; One third of patients with hippocampal sclerosis (HS) under- going epilepsy surgery fail to become seizure free (NSF); risk factors include bilateral pathology and frequent generalized seizures. At the group level, increased periventricular [11C]flumazenil binding (indicating heterotopic neuron concentration) was associated with NSF outcome. Here, we investigate in new larger cohorts whether preoperative white matter (WM) uptake of [11C]flumazenil or the more widely used FDG predicts NSF outcome in individuals.
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- 2012
31. Periventricular flumazenil binding for predicting postoperative outcome in individual patients with temporal lobe epilepsy and hippocampal sclerosis
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Yankam Njiwa, J., Costes, N., Bouvard, S., Redouté, J., Ryvlin, P., Hammers, A., Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Translational and integrative group in epilepsy research, Lyon Neuroscience Research center, Division of Experimental Medicine, Imperial College London, Fondation neurodis, and Fondation Neurodis
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[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2012
32. Implémentation et développement d'un outil d'analyse d'IRM: aide à la detection de lesions épilpetogènes dysplasiques
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Ghrenassia, S., Hammers, A., Ryvlin, P., Yankam Njiwa, J., Heckemann, R. A., Costes, N., Division of Experimental Medicine, Imperial College London, Fondation neurodis, Fondation Neurodis, Translational and integrative group in epilepsy research, Lyon Neuroscience Research center, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
- Subjects
[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2012
33. L'hippocampe et l'amygdale humains : Création de cartes probabilistes dans l'espace MNI, et comparaison quantitative de stratégies de normalisation spatiale
- Author
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Vial, C., Belgacem, M., Heckemann, R. A., Yankam Njiwa, J., Allom, R., Chen, C.H., Costes, N., Hammers, A., Division of Experimental Medicine, Imperial College London, Fondation neurodis, Fondation Neurodis, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), and Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)
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[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2012
34. Indicateurs de suivi des non-conformités des prélèvements immuno-hématologiques : l’expérience du GH et du site EFS Pitié-Salpêtrière
- Author
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Roy, S., primary, Taouqi, M., additional, Levy, C., additional, Costes, N., additional, Mercadier, A., additional, and Langeron, O., additional
- Published
- 2015
- Full Text
- View/download PDF
35. Advanced [18F]FDG and [11C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis
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Yankam Njiwa, J., primary, Gray, K.R., additional, Costes, N., additional, Mauguiere, F., additional, Ryvlin, P., additional, and Hammers, A., additional
- Published
- 2015
- Full Text
- View/download PDF
36. Quality Procedures in the European Higher Education Area and Beyond : Second ENQA Survey
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Costes, N., Crozier, F., Cullen, P., Grifoll, J., Harris, N., Helle, E., Hopbach, A., Kekäläinen, H., Knežević, Božana, Sits, T., and Sohm, K.
- Subjects
quality assurance higher education - Abstract
This book is concerned with the 2008 Quality Procedures survey on quality assurance agencies within the European Higher Education Area (EHEA). Undertaken by the European Association for Quality Assurance in Higher Education (ENQA), it collates and analyses responses from 51 agencies and related bodies, and provides an update on a similar survey undertaken in 2002. The initial chapter identifies the responding agencies, their countries and their ENQA status, and the extent of their remits. Most but not all agencies work within a national remit but a few also have international ones as well. Remits vary from those covering only one type of institution to those with a far wider range of responsibilities, often encompassing essentially all higher education provision, and in some cases various support services as well. The ‘ level’ at which quality assurance responsibilities are held shows some interesting patterns ; in about half of the cases the institutions are responsible for approval of new subject areas, but when it comes to programmes the role of the relevant QA agency rises markedly. Approval of new institutions is typically done by central or regional government, but not in all cases. Chapter 2 provides details on the status, structures, activities and resources of the QA agencies. It pays particular attention to those issues covered by Part 3 of the European Standards and Guidelines (ESG), and is of interest regarding criteria that are also used for ENQA membership. The analysis and commentary acknowledge that there can be a strained relationship between national traditions, legislation and the ESG. The responses illustrate that almost all agencies are formally recognised, either under a specific law (most) or by public authorities. The number of agencies within a country varies ; in most cases there is a single agency, but regional and other dimensions can result in there being multiple agencies within a country. The analysis of the types of activities covered by agencies shows that, whilst two-thirds of agencies use programme level procedures, just less than half work at institutional level. Some agencies cover both. QA procedures are generally undertaken on a cyclical rather than one-off basis, and generally result in formal consequences. One of the significant sets of responses in this part of the survey indicates that, within a five year period, three-quarters of the agencies have undertaken or are undertaking change, or planning changes to their procedures. Data on staffing, funding and other resources provide an interesting snap-shot of generally adequate provision, but also illustrate some constraints under which agencies are working. The third and most extensive chapter is concerned with structure(s), functions, decision making and methodological approaches to external quality assurance. A very rich source of data illustrates the increasing extent to which stakeholders are now involved within agency structures, although the main functions of agencies (external quality assurance and improvement, and dissemination of information about quality) remain much the same as in 2003. Agencies have however taken on, or become involved in, a wider range of additional functions, particularly in relation to the development of the Bologna Process. One interesting finding is that the 4-stage theoretical model of quality assurance, presented in an annex of the ESG, is applied by most but not all of the responding agencies. Within the details of what is examined during the external evaluations, research strategies and assessment ranked highly, but a surprising 20% of agencies indicated that they do not include institutions’ assessments of students in their evaluations. A variety of mechanisms is used by agencies to look at their own internal quality assurance procedures with, as might be expected, the more developed agencies having a wider range of measures than those established more recently. Chapter 4 provides further evidence that builds upon important aspects coming from Chapter 3. It describes and discusses a number of critical areas relating to the division of responsibilities within the methodological frameworks and procedures used by agencies. It reports on: the membership of external panels [there is clear evidence of an increase in student membership but a (corresponding?) decrease in the direct involvement of agency staff on panels)] ; the training of panels ; the responsibilities exercised in determining what QA method(s) will be applied (mostly the agency’ s) and the writing of reports (mostly the panel’ s). Legal regulations provide a reference frame for many agencies in determining their methodologies, but there are other important factors as well. An interesting comparison with the 2003 survey may be drawn from the now wider availability and use of ‘ specific criteria and standards’ for QA. The quality assurance of collaborative provision between (providing) institutions (including trans-national delivery) was not covered in 2003 ; the data provided here may act as a baseline for future comparisons in an area that is becoming of increasing importance. Chapter 5 focuses on just one critical aspect of QA – site visits, and the preparatory work undertaken before them. Evidence suggests that the development of the self-evaluation reports is done by institutions in much the same way as in 2003 ; sources for data collection are much as might be expected and the people and panels interviewed much as in 2003. The site visits themselves are generally, but not always, accompanied by agency staff, and whilst averages can be distorting it was perhaps interesting to see that site visits for institutional evaluations are only one day longer than those for programme evaluations. Class room observations were used in a small proportion of methodologies / cases only. The sixth chapter covers the extent to which, and the ways in which, the outcomes of the QA procedures are reported. Most agencies provide public reports on their evaluations, with those that do not yet do so are planning to. The majority of reports, which include data analyses, recommendations, and conclusions, are subject to some form of ‘ consultation’ with the institution before final publication. It is usually the agency that published the report, with the number of reports published clearly depending on the size of an agency’ s ‘ jurisdiction’ and whether it is involved in only institutional evaluation or programme evaluations, when the number of reports rises considerably, or both. This is followed in Chapter 7, as in any typical QA methodology, by consideration of follow-up procedures after any judgements and recommendations have been made. Various responsibilities lie with both agencies and institutions, and there are a range of actions that can be asked for or required of institutions. Some preliminary thoughts about possible future developments are covered briefly in the penultimate chapter. Revisions to external QA procedures figure highly in the responses, as does the development of national qualifications frameworks. Almost all agencies have undergone, are undergoing, or are planning to undergo an external evaluation themselves, although a small proportion do not, as yet, intend to apply for membership of the European Quality Assurance Register (EQAR). The final chapter aims to summarise the key findings not in a repetitive way but by seeking to provide interesting insights into similarities and differences through cross referring detailed findings and discussion points that have arisen from various parts of the survey.
- Published
- 2008
37. P.1.g.010 - Exploration of the concept of 5-HT1A receptor biased agonists: a multimodal imaging study
- Author
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Vidal, B., Fieux, S., Redouté, J., Villien, M., Le Bars, D., Newman-Tancredi, A., Costes, N., and Zimmer, L.
- Published
- 2017
- Full Text
- View/download PDF
38. P.1.g.009 - 5-HT1A biased agonists induce different hemodynamic responses: a pharmacological MRI study
- Author
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Vidal, B., Bolbos, R., Redouté, J., Langlois, J.B., Fieux, S., Bouillot, C., Costes, N., Newman-Tancredi, A., and Zimmer, L.
- Published
- 2017
- Full Text
- View/download PDF
39. Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury
- Author
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Richard, J.-C., BrÉgeon, F., Leray, V., Le Bars, D., Costes, N., Tourvieille, C., Lavenne, F., Devouassoux-Shisheboran, Mojgan, Gimenez, G., Guérin, C., Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,[SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SPI.MECA.MEMA] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[PHYS.MECA.MEMA] Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[PHYS.MECA.MEFL] Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing ,[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph] ,[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Mechanics of the fluids [physics.class-ph] ,[PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV] ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation ,[PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Abstract
article
- Published
- 2007
40. Boundary value problems with incremental plasticity in granular media
- Author
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Chung, T. J., primary, Lee, J. K., additional, and Costes, N. C., additional
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- 1974
- Full Text
- View/download PDF
41. Functional anatomy of the therapeutic effects of prism adaptation on left neglect
- Author
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Luauté, J, Michel, C., Rode, G., Pisella, Laure, Jacquin-Courtois, S., Costes, N., Cotton, F., Le Bars, D., Boisson, D., Halligan, P., Rossetti, Y., Luauté, J., Pisella, L., Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Littoral, Environnement, Télédétection, Géomatique (LETG - Caen), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Université de Lyon, Hôpital Henry Gabrielle [CHU - HCL], Hospices Civils de Lyon (HCL), Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), School of Psychology [Cardiff University], Cardiff University, Centre de recherche en neurosciences de Lyon (CRNL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Brain mapping ,0302 clinical medicine ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,Cortex (anatomy) ,media_common ,Lenses ,Temporal cortex ,Aged, 80 and over ,Brain Mapping ,05 social sciences ,Stroke Rehabilitation ,Brain ,Adaptation, Physiological ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,Stroke ,medicine.anatomical_structure ,Treatment Outcome ,Cerebral blood flow ,Cerebrovascular Circulation ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Female ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Psychology ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,media_common.quotation_subject ,education ,Posterior parietal cortex ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,050105 experimental psychology ,Neglect ,Perceptual Disorders ,03 medical and health sciences ,medicine ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Humans ,0501 psychology and cognitive sciences ,Aged ,[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,Recovery of Function ,Functional imaging ,Positron-Emission Tomography ,Neurology (clinical) ,Prism adaptation ,Neuroscience ,030217 neurology & neurosurgery ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Objective: To investigate the anatomic substrates underlying the beneficial effect of prism adaptation in five patients with persistent left neglect following right stroke. Methods: In a functional imaging PET study, we used a covariation analysis to examine linear changes of regional cerebral blood flow over sessions as a function of left neglect improvement. Results: The network of significant brain regions associated with improvement of left neglect performance produced by prism adaptation involved the right cerebellum, the left thalamus, the left temporo-occipital cortex, the left medial temporal cortex, and the right posterior parietal cortex. Conclusion: Our results suggest that the realignment of visuomotor coordinates is processed by the cerebellum and that low level sensorimotor adaptation actively modulates cerebral areas, albeit now relying on intact cerebellocerebral connections. Hence, our data support the hypothesis that the beneficial effect of prism adaptation on the clinical presentation of left neglect derives from modulation of cortical regions implicated in spatial cognition.
- Published
- 2006
42. Mechanisms leading to reversible mechanical dysfunction in severe CAD : the alternatives to mycardical stunning
- Author
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Mazzadi, A., André-Fouet, X., Costes, N., Croisille, P., Revel, D., Marc Janier, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Laboratoire Creatis, Compte Général
- Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV] ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing - Abstract
article
- Published
- 2006
43. Creation and Application of a Simulated Database of Dynamic [18F]MPPF PET Acquisitions Incorporating Inter-Individual Anatomical and Biological Variability
- Author
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Reilhac, A., Evans, A., Gimenez, G., Costes, N., Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,[SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,[SPI.MECA.MEMA] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,[PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[PHYS.MECA.MEMA] Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,[PHYS.MECA.MEFL] Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing ,[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph] ,[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Mechanics of the fluids [physics.class-ph] ,[PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV] ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,[PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing - Abstract
article
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- 2006
44. Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI.
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Njiwa, J. Yankam, Costes, N., Bouillot, C., Bouvard, S., Fieux, S., Becker, G., Levigoureux, E., Kocevar, G., Stamile, C., Langlois, J. B., Bolbos, R., Bonnet, C., Bezin, L., Zimmer, L., and Hammers, A.
- Abstract
Inflammation may play a role in the development of epilepsy after brain insults. [11C]-(R)-PK11195 binds to TSPO, expressed by activated microglia. We quantified [11C]-(R)-PK11195 binding during epileptogenesis after pilocarpineinduced status epilepticus (SE), a model of temporal lobe epilepsy. Nine male rats were studied thrice (D0-1, D0+6, D0+35, D0=SE induction). In the same session, 7T T2-weighted images and DTI for mean diffusivity (MD) and fractional anisotropy (FA) maps were acquired, followed by dynamic PET/CT. On D0+35, femoral arterial blood was sampled for rat-specific metabolite-corrected arterial plasma input functions (AIFs). In multiple MR-derived ROIs, we assessed four kinetic models (two with AIFs; two using a reference region), standard uptake values (SUVs), and a model with a mean AIF. All models showed large (up to two-fold) and significant TSPO binding increases in regions expected to be affected, and comparatively little change in the brainstem, at D0+6. Some individuals showed increases at D0+35. AIF models yielded more consistent increases at D0+6. FA values were decreased at D0+6 and had recovered by D0+35. MD was increased at D0+6 and more so at D0+35. [11C]-(R)-PK11195 PET binding and MR biomarker changes could be detected with only nine rats, highlighting the potential of longitudinal imaging studies. [ABSTRACT FROM AUTHOR]
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- 2017
- Full Text
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45. Quantitative assessment of regional alveolar ventilation and gas volume using 13N-N2 washout and PET
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Jc, Richard, Janier M, Franck LAVENNE, Tourvieille C, Le Bars D, Costes N, Gimenez G, Guerin C, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Laboratoire Creatis, Compte Général
- Subjects
[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Swine ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,[SPI.MECA.MEFL] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,[SPI.MECA.MEFL]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Fluids mechanics [physics.class-ph] ,[PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing ,[SPI.MECA.BIOM] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,Respiratory Distress Syndrome ,[PHYS.MECA.MEFL]Physics [physics]/Mechanics [physics]/Mechanics of the fluids [physics.class-ph] ,[SPI.MECA.BIOM]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Biomechanics [physics.med-ph] ,[PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV] ,[INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV] ,[SDV.IB]Life Sciences [q-bio]/Bioengineering ,Female ,[INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation ,[PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph] ,[SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing ,Algorithms ,Radioisotope Dilution Technique ,[INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing ,Metabolic Clearance Rate ,Nitrogen ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,Models, Biological ,[SPI.MECA.MEMA] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph] ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,[PHYS.MECA.MEMA] Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] ,Administration, Inhalation ,Image Interpretation, Computer-Assisted ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Tidal Volume ,Animals ,[PHYS.MECA.MEFL] Physics [physics]/Mechanics [physics]/Fluid mechanics [physics.class-ph] ,Computer Simulation ,[PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing ,[SDV.IB] Life Sciences [q-bio]/Bioengineering ,[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph] ,[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph] ,Nitrogen Radioisotopes ,[PHYS.MECA.BIOM] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] ,[INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation ,Pulmonary Alveoli ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,Positron-Emission Tomography ,[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Radiopharmaceuticals ,Pulmonary Ventilation ,Oleic Acid - Abstract
Measurement of alveolar volume (Va) and regional ventilation (a) is crucial to understanding the pathophysiology of acute lung injury and ventilator-induced lung injury. PET has previously been used as a noninvasive, quantitative method to assess a, but formal validation of this technique in experimental lung injury is lacking. This study aims to validate Va and a regional assessment with PET, using inhaled (13)N-N(2) in pigs.Two normal and 2 oleic acid-injured pigs were tracheotomized, mechanically ventilated, and studied in 5 different levels of ventilation by changing respiratory rate. In each experimental condition, lungs were washed-in and then washed-out with (13)N-N(2) through an open circuit in the ventilator. Using this method, multiframe images were acquired with a dedicated PET camera. Regions of interest (ROIs) were drawn on each lung. Regional time-activity curves during washout were generated for each ROI and fitted to a mono- and a bicompartmental model. Validation of this method was performed in 2 ways. First, regional values of predicted Va (Va(emission)) were compared with regional volume obtained independently from density analysis on a transmission scan (Va(trans)). Second, regional values of predicted a were summed in each animal during each experimental condition and compared with minute-ventilation values set on the ventilator.The bicompartmental model best fitted the experimental values in normal (94.7% [62.2%-100.0%] (median [interquartile range]) of the ROIs) as well as in injured animals (90.7% [81.6%-97.4%] of the ROIs) (P = 0.49). Va(emission) significantly correlated with Va(trans) (R(2) = 0.89, P0.001) but exceeded Va(trans) by 10%. Finally, a strongly and positively correlated with minute-ventilation in both normal (R(2) = 0.96, P0.001) and injured (R(2) = 0.96, P0.001) animals.Measurement of (13)N-N(2) washout using PET is accurate to assess regional alveolar volume and ventilation during experimental acute lung injury.
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- 2005
46. Displacement Detectability of [18F]MPPF from 5-HT1A Receptors by Endogenous Serotonin: a Monte Carlo Simulation Study
- Author
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Costes, N., Reilhac, A., Martinez-Möller, A., and Merlet, I.
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MedicalImaging, CAMP,PET, Neurology, Montecarlo, KineticModelling ,ddc - Abstract
Introduction: 5-HT1A receptors are largely involved in psychiatric and neurological disorders such as depression, schizophrenia, dementia, or epilepsy. The MPPF fluorine 18 labeled tracer, competitor to endogenous serotonin binding on 5-HT1A receptors, has been quantified and validated for clinical investigations. Studies in rat have shown that variations in serotonin concentration can be detected with MPPF, which would be on particular interest for human in vivo examination. Although theoretically, the discrimination of a displacement in non-noisy modeled kinetic is obvious, it may be undetectable in noisy real conditions of measure with PET. Objective: The aim of this study was to evaluate the detectability of a displacement of MPPF binding consecutive to a serotonin release on a Monte-Carlo simulated PET data set. Methods: Six MPPF PET dynamic data set were simulated with the SORTEO Monte-Carlo simulator reproducing the physical disintegration process, the photon transport and the detection by CTI Exact HR+ camera. Emission volumes came from segmented MRI brain images classified in labeled cortical and subcortical brain structures (Fig A.). In regions rich in 5-HT1A receptor, emission kinetics were analytically simulated from the compartmental model. Regions from the right hemisphere had a standard kinetics resulting from a single bolus injection of [18F]-MPPF tracer dose, whereas homologous regions of the left hemisphere resulted from a more complex model including a endogenous compartment from which a release of serotonin was simulated 20 minutes post-injection (Fig B). In regions poor in 5-HT1A receptors and in background, kinetics were extracted from actual PET data obtained from a normative database acquired with our HR+ camera. After the simulation of PET acquisition processes (Fig C), regional time-activity curves were extracted from dynamic PET data to compute MPPF binding parameters with an adequate model. Parametric images were also computed. A statistical analysis of normal regions versus regions with displacement was performed to detect serotonin concentration modifications, both in ROI level and in a voxel based level with SPM. Simulated data were compared with actual data to evaluate realism of the simulations and detectability of displacement. Results: Comparisons between left and right mean ROI values revealed a significant difference induced by the serotonin release. The individual SPM analysis did not reveal significant differences with normal subjects, whereas in the SPM group analysis, significant differences were found in some clusters located in regions with displacement. In conclusion, the sensitivity for detecting a displacement depended on the availability of 5-HT1A receptor, the number of subjects, and the size of cortical structures.
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- 2004
47. The clearPET' LSO/LuYAP phoswich scanner: a high performance small animal PET system
- Author
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Ziemons, K., Auffray, E., Barbier, R., Brandenburg, G., Bruyndonckx, P., Choi, Y., Christ, D., Costes, N., Declais, Y., Devroede, O., Dujardin, C., Fedorov, A. A., Heinrichs, U., Hollendung, A., Korjhik, M. J., Krieguer, M., Kuntner, C., Largeron, G., Lartizien, C., Larue, H., Lecoq, P., Leonard, S., Marteau, J., Morel, C., Mosset, J. B., Parl, C., Pedrini, C., Petrosyan, A. G., Pietrzyk, U., Rey, M., Saladino, S., Sappey-Marinier, D., Marc Janier, Simon, L., Streun, M., Tavernier, S., Vieira, J. M., Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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imagerie_isotopique ,reseau_international ,SDV:MHEP ,imagerie_morphologique_fonctionnelle - Abstract
article
- Published
- 2004
48. Inclusion de l’hémovigilance et de la sécurité transfusionnelle dans la politique de qualité et sécurité des soins : l’expérience du Groupe Hospitalier et du site EFS Pitié-Salpêtrière
- Author
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Roy, S., primary, Taouqi, M., additional, Delort, J., additional, Marachet, A.L., additional, Costes, N., additional, Levy, C., additional, Mercadier, A., additional, and Nguyen, L., additional
- Published
- 2014
- Full Text
- View/download PDF
49. Increased serotonin receptor availability in human sleep: Evidence from an [18F]MPPF PET study in narcolepsy.
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Tochon-Danguy H., Mulligan R., Reutens D., Zimmer L., Berkovic S.F., Costes N., Derry C., Benjamin C., Bladin P., Le Bars D., Tochon-Danguy H., Mulligan R., Reutens D., Zimmer L., Berkovic S.F., Costes N., Derry C., Benjamin C., Bladin P., and Le Bars D.
- Abstract
Data from animal studies suggest that serotonin release promotes wakefulness and suppresses REM sleep, but there are dangers in extrapolating these findings to humans. Binding of the radioligand [18F]MPPF to 5HT1A receptors is sensitive to levels of endogenous serotonin. In this study, we aimed to demonstrate changes in serotonin receptor availability in the human brain in wakefulness and sleep using [18F]MPPF and positron emission tomography. 14 subjects with narcolepsy cataplexy underwent [18F]MPPF PET scans in wakefulness and in sleep. Subjects who used the stimulant methylphenidate took their normal medication for the wake scan but omitted it prior to the sleep scan. The change in binding potential (BP) between the sleep and wake scans was examined using paired t test. Methylphenidate is thought to have little or no effect on serotonergic neurotransmission, and in order to confirm the absence of an effect on [ 18F]MPPF binding, a concurrent study was performed using a beta-microprobe technique to examine the effect of methylphenidate administration on [18F]MPPF binding in Sprague-Dawley rats. The human study showed a significant increase in [18F]MPPF binding in sleep compared to wakefulness in the whole brain and all regions of interest examined (temporal cortex, mesial temporal region and cingulate cortex). The beta-microprobe study confirmed that methylphenidate administration had no effect on [18F]MPPF binding. These findings indicate that serotonin receptor availability is increased in sleep compared to wakefulness in narcoleptic humans. © 2005 Elsevier Inc. All rights reserved.
- Published
- 2012
50. Third party logistics, the provider and the shipper perspective
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Laarhoven, van, P.J.M., Fabbe-Costes, N, Colin, J, Paché, G, and Operations Planning Acc. & Control
- Published
- 2000
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