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11. Inhibitors of ocular neovascularization: Promises and potential problems

Author

Wijngaarden, Peter van, Coster, Douglas J., and Williams, Keryn A.

Subjects
Vascular endothelial growth factor -- Research, Diabetics -- Health aspects, Vision disorders -- Risk factors, Vision disorders -- Prevention, Neovascularization -- Risk factors
Abstract

Vision loss caused by ocular neovascularization in diabetic retinopathy and exudative age-related macular degeneration (ARMD) can be prevented by using molecular medicines. Details about various researches carried out in the angiogenesis and discussions regarding vascular endothelial growth factor are discussed.

Published
2005

13. LIST OF CONTRIBUTORS

Author

Abad, Juan C., primary, Abbott, Richard L., additional, Ahmad, Omar, additional, Aigner, Tracy L., additional, Akpek, Esen Karamürsel, additional, Albert, Daniel M., additional, Azar, Dimitri T., additional, Balali, Siamak, additional, Barney, Neal P., additional, Behrens, Ashley, additional, Bernal, Marial D., additional, Brass, Robert E., additional, Braun, Erich H.P., additional, Brent, Geoffrey, additional, Brightbill, Frederick S., additional, Burk, Linda L., additional, Burkat, Cat N., additional, Cavanaugh, Timothy B., additional, Chang, Daniel H., additional, Chen, Edwin S., additional, Chen, Min, additional, Chew, Jesse, additional, Chow, Christopher Y., additional, Chuck, Roy S., additional, Cionni, Robert J., additional, Clamen, Liane, additional, Cockerham, Glenn C., additional, Cooke, Carole A., additional, Coster, Douglas J., additional, Cox, Constance, additional, Criden, Marc R., additional, Dahlgren, Matthew Alan, additional, Dawson, Daniel, additional, Daya, Sheraz M., additional, Djalilian, Ali R., additional, Doane, John F., additional, Dogru, Murat, additional, Doherty, Terence J., additional, Dohlman, Claes H., additional, Donnenfeld, Eric D., additional, Donshik, Peter C., additional, Dunn, Steven P., additional, Dupps, William J., additional, Edelhauser, Henry, additional, Ehlers, William, additional, Espinosa-Lagana, Marcela, additional, Evangelista, Jason, additional, Faktorovich, Ella G., additional, Farah, Samir G., additional, Farid, Marjan, additional, Farjo, Ayad A., additional, Farjo, Qais Anastas, additional, Fini, M. Elizabeth, additional, Ford, Jerry G., additional, Foster, C. Stephen, additional, Fouraker, Bradley, additional, Fournié, Pierre, additional, Garg, Prashant, additional, Geroski, Dayle H., additional, Giegengack, Matthew, additional, Ginsberg, Steven Paul, additional, Glasser, David B., additional, Gordon, Michael, additional, Gordon, Gabriel M., additional, Gorovoy, Mark S., additional, Gottsch, John D., additional, Green, Colin R., additional, Haight, David H., additional, Haller, Julia A., additional, Hamada, Samer, additional, Hardten, David R., additional, Hauswirth, Scott G., additional, Heidemann, David G., additional, Herrygers, Lisa, additional, Herz, Natasha L., additional, Hodge, Christopher, additional, Hoffer, Kenneth J., additional, Holland, Edward J., additional, Jackson, Randolph T., additional, Jakobs, Frank M., additional, John, Thomas, additional, Jun, Albert S., additional, Kahana, Alon, additional, Kara-Jose, Andrea Cotait, additional, Katz, Steven E., additional, Klyce, Stephen D., additional, Koch, Douglas D., additional, Kornmehl, Ernest W., additional, Krachmer, Jay H., additional, Kulkarni, Amol D., additional, Laibson, Peter R., additional, Laing, Ronald A., additional, Lanier, Jeffrey Day, additional, Lass, Jonathan H., additional, Lawless, Michael A., additional, Ledee, Dolena R., additional, Lee, James, additional, Lee, Janet, additional, Lee, Yunhee, additional, Lekhanont, Kaevalin, additional, Lembach, Richard G., additional, Levenson, Jeremy E., additional, Leyngold, Ilya M., additional, Liesegang, Thomas J., additional, Lindquist, Thomas D., additional, Lindstrom, Richard L., additional, Lucarelli, Mark J., additional, Lucas-Glass, Tina C., additional, Macsai, Marian S., additional, Mahran, Waleed, additional, Manns, Fabrice, additional, Martins, Suy Anne R., additional, Mathers, William D., additional, McDonnell, Peter J., additional, McGhee, Charles N.J., additional, Meisler, David M., additional, Mian, Shahzad, additional, Milne, H. L. Rick, additional, Mondino, Bartly J., additional, Muenzler, W. Stanley, additional, Nassiri, Nariman, additional, Nehls, Sarah, additional, Newton, Catherine, additional, Noguera, Guillermo E., additional, Nordlund, Michael L., additional, Oleynikov, Yuri S., additional, Olson, Randall J., additional, Onclinx, Tania M., additional, Ongucci, Tatsuya, additional, Oshika, Tetsuro, additional, Panday, Vasudha A., additional, Patel, Sanjay V., additional, Pepose, Jay S., additional, Pfister, Daryl R., additional, Pfister, Roswell R., additional, Delong Potter, Heather Anne, additional, Prakash, Gaurav, additional, Price, Marianne O., additional, Price, Francis W., additional, Probst, Louis E., additional, Qazi, Mujtaba A., additional, Rao, Gullapalli N., additional, Rapuano, Christopher J., additional, Reddy, Satya V., additional, Reed, John William, additional, Reinhart, William J., additional, Roberts, Cynthia J., additional, Rose, Linda, additional, Rosenfeld, Steven, additional, Rothman, Jason S., additional, Rowsey, James, additional, Rubinfeld, Roy Scott, additional, Schanzlin, David J., additional, Serdarevic, Olivia N., additional, Shamie, Neda, additional, Sharma, Namrata, additional, Shaw, Edward, additional, Sherwin, Trevor, additional, Shimmura, Shigeto, additional, Sindt, Christine, additional, Slade, Stephen, additional, Solomon, Renée, additional, Soong, Kaz, additional, Stark, Walter J., additional, Steinert, Roger F., additional, Sugar, Joel, additional, Sugar, Alan, additional, Suh, Leejee H., additional, Sutphin, John E., additional, Terry, Mark A., additional, Thompson, Matthew Joseph, additional, Tsubota, Kazuo, additional, Tu, Elmer Y., additional, Vajpayee, Rasik B., additional, Vakharia, Mitul R., additional, Van Buren, Jeremy, additional, Van Meter, Woodford S., additional, Vastine, David W., additional, Verity, Steven M., additional, Vito, Elizabeth C.L., additional, Wadia, Hormuz P., additional, Wagoner, Michael D., additional, Waller, Stephen G., additional, Wang, Li, additional, Waring, George O., additional, Werner, Liliana, additional, Weston, Bonnie C., additional, Wheeldon, Catherine E., additional, Williams, Keryn A., additional, Williams, John, additional, Yoon, Eric Y., additional, Zaidman, Gerald W., additional, and Zoumalan, Christopher I., additional

Published
2009
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27. The efficacy of a nurse-led preoperative cataract assessment and postoperative care clinic

Author

Pesudovs, Konrad, Kirkwood, Bradley J., Coster, Douglas J., and Latimer, Paul

Subjects
Postoperative care -- Services, Nurse practitioners -- Practice, Cataract -- Care and treatment, Health
Abstract

A specialist nurse-led cataract clinic was introduced to improve access to care in the Department of Ophthalmology at Flinders Medical Centre in 2003 where an ophthalmic nurse practitioner could assess patients for visually disabling cataract and provide specialist postoperative care for cataract surgery patients. Quality assurance mechanisms, including an education and feedback loop, were established to identify and monitor safe practices and to detect suboptimal management.

Published
2006

31. Is directed donation misguided?

Author

Sherwin, Trevor, Coster, Douglas J, La Nauze, Jamie, Merry, Alan, Pendergrast, David, and Armitage, W John

Published
2004

40. Pathways of Corneal and Ocular Surface Inflammation: A Perspective from the Cullen Symposium

Author

McDermott, Alison M., Perez, Victor, Huang, Andrew J.W., Pflugfelder, Stephen C., Stern, Michael E., Baudouin, Christophe, Beuerman, Roger W., Burns, Alan R., Calder, Virginia L., Calonge, Margarita, Chodosh, James, Coster, Douglas J., Dana, Reza, Hazlett, Linda D., Jones, Dan B., Kim, Stella K., Knop, Erich, Li, De-Quan, Mitchell, Bradley M., Niederkorn, Jerry Y., Pearlman, Eric, Wilhelmus, Kirk R., and Kurie, Elaine

Published
2005
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41. Author reply

Author

Coster, Douglas J., primary, Keane, Miriam C., additional, and Williams, Keryn A., additional

Published
2015
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42. Is there evidence for a surgeon learning curve for endothelial keratoplasty in Australia?

Author

Keane, Miriam C, Mills, Richard AD, Coster, Douglas J, and Williams, Keryn A

Subjects
CORNEA surgery, SURGEONS, TRANSPLANTATION of organs, tissues, etc., SURVIVAL analysis (Biometry), LEARNING curve
Abstract

Importance Expected outcomes from endokeratoplasty may vary with surgeon experience. Background It was explored whether a surgeon learning curve exists for Descemet stripping endothelial keratoplasties (manual or automated) performed in Australia. Design This is a prospective cohort study, with various clinical settings. Participants There were 2139 recipients of 2615 endothelial grafts, registered by 85 surgeons between January 2006 and December 2013. Methods Kaplan-Meier survival analyses and Cox proportional hazards regression were used to examine longitudinal graft survival. Manual and automated Descemet stripping endothelial keratoplasties were analysed together. Pearson chi-squared analyses were performed to examine differences amongst groups. Continuity correction was used for 2 × 2 tests, and statistical significance was set at P < 0.05 (two-sided). Main outcome measure The main parameter measured was endothelial graft survival. Results Survival of the first 56 registered grafts was significantly poorer than survival of subsequent grafts (χ2 = 8.83, df = 1, P = 0.003), when data were combined for all surgeons. Surgeon workload influenced graft survival significantly ( P < 0.001). This variable was retained in multivariate analysis designed to investigate independent factors influencing graft survival. Primary non-functioning grafts were significantly less likely to be reported for endokeratoplasties performed by surgeons with more than 56 registered grafts, compared with those registering 56 or fewer grafts (4.3% vs. 8.5%; χ2 = 18.38, df = 1, P < 0.001). Conclusions and Relevance Our findings suggest that for less experienced or low-volume surgeons, longitudinal graft survival improved once 56 or more endokeratoplasties had been performed, indicative of a learning curve. The learning curve was less apparent for surgeons with 57 or more Descemet stripping endothelial keratoplasties and/or Descemet stripping automated endothelial keratoplasties registered during the 8-year study period. Different learning curves may be anticipated for these two groups of surgeons. [ABSTRACT FROM AUTHOR]

Published
2017
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44. Author reply

Author

Coster, Douglas J., primary, Keane, Miriam C., additional, and Williams, Keryn A., additional

Published
2014
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50. A comparison of endothelial and penetrating keratoplasty outcomes following failed penetrating keratoplasty: a registry study.

Author

Keane, Miriam C., Galettis, Rachel A., Mills, Richard A. D., Coster, Douglas J., and Williams, Keryn A.

Abstract

Purpose: To compare graft survival and visual outcomes for endothelial keratoplasty (EK) after a first penetrating keratoplasty (PK), with outcomes of repeat PK after a first PK. Methods: 400 eyes with a second graft (65 EKs, 335 PKs) performed after failure of a primary PK were identified through the Australian Corneal Graft Registry, a national prospectively followed cohort. Grafts were performed after January 2008 (follow-up of the second graft extending to 6.75 years maximum). Kaplan-Meier graft survival plots were constructed and Cox proportional hazards regression was used to identify independent risk factors for graft failure. Best-corrected Snellen visual acuity (BCVA) at last follow-up was compared with pregraft acuity. Results: Poor Kaplan-Meier graft survival was observed for PK-EK compared with PK-PK (log-rank=29.66, p<0.001). Variables retained in multivariate analysis as significantly influencing survival of the second graft included graft type (PK-EK or PK-PK, p<0.001), length of survival of the previous PK (global p=0.011), graft era (global p=0.018), occurrence of rejection in the second graft (p=0.005) and a history of raised intraocular pressure at any time (p=0.048), but not indication for the first graft. BCVA improved in the majority of surviving grafts and attainment of 6/12 vision was similar for both PK-EK and PK-PK groups. Conclusions: Our registry findings suggest that repeat PK may deliver a better outcome in terms of graft survival than EK after a failed PK that was performed initially for keratoconus or pseudophakic bullous keratopathy. For surviving grafts, visual outcomes appeared equivalent across groups. [ABSTRACT FROM AUTHOR]

Published
2016
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