341 results on '"Coste, André"'
Search Results
2. Chronic Rhinosinusitis Outcome Registry (CHRINOSOR): Establishment of an International Outcome Registry Driven by mHealth Technology
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Seys, Sven F., Hellings, Peter W., Alobid, Isam, Backer, Vibeke, Bequignon, Emilie, von Buchwald, Christian, Cavaliere, Carlo, Coste, André, Deneyer, Lauren, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Gane, Simon, Gevaert, Philippe, Holbaek-Haase, Christiane, Holzmeister, Clemens, Hopkins, Claire, Hox, Valérie, Huart, Caroline, Jankowski, Roger, Jorissen, Mark, Kjeldsen, Anette, Knipps, Lisa, Lange, Bibi, van der Lans, Rik, Laulajainen-Hongisto, Anu, Larsen, Kenneth, Liu, David T., Lund, Valerie, Mariën, Gert, Masieri, Simonetta, Mortuaire, Geoffrey, Mullol, Joaquim, Reitsma, Sietze, Rombaux, Philippe, Schneider, Sven, Steinsvik, Andreas, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna K., Van Gerven, Laura, Van Zele, Thibaut, Virkkula, Paula, Wagenmann, Martin, and Bachert, Claus
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- 2023
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3. Desloratadine, an FDA-approved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry
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Morin-Dewaele, Margot, Bartier, Sophie, Berry, François, Brillet, Rozenn, López-Molina, Dennis Salomón, Nguyễn, Công Trung, Maille, Pascale, Sereno, Kevin, Nevers, Quentin, Softic, Laurent, Vaugeois, Jean-Marie, Louis, Bruno, Bequignon, Emilie, Bruscella, Patrice, Coste, André, Pawlotsky, Jean-Michel, Jamain, Stéphane, and Ahmed-Belkacem, Abdelhakim
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- 2022
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4. Presentation, Diagnosis, and Management of Subglottic and Tracheal Stenosis During Systemic Inflammatory Diseases
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Catano, Jennifer, Uzunhan, Yurdagul, Paule, Romain, Dion, Jérémie, Régent, Alexis, Legendre, Paul, Gonin, François, Martinod, Emmanuel, Cohen, Pascal, Puéchal, Xavier, Le Guern, Véronique, Mouthon, Luc, Coste, André, Lorut, Christine, La Croix, Candice, Périé, Sophie, and Terrier, Benjamin
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- 2022
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5. Dupilumab prevents nasal epithelial function alteration by IL‐4 in vitro: Evidence for its efficacy.
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Fieux, Maxime, Carsuzaa, Florent, Bellanger, Yvan, Bartier, Sophie, Fournier, Virginie, Lecron, Jean Claude, Bainaud, Matthieu, Louis, Bruno, Tringali, Stéphane, Dufour, Xavier, Coste, André, Favot, Laure, and Bequignon, Emilie
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- 2024
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6. Skewed X-chromosome inactivation drives the proportion of DNAAF6-defective airway motile cilia and variable expressivity in primary ciliary dyskinesia.
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Thomas, Lucie, Cuisset, Laurence, Papon, Jean-Francois, Tamalet, Aline, Pin, Isabelle, Taam, Rola Abou, Faucon, Catherine, Montantin, Guy, Tissier, Sylvie, Duquesnoy, Philippe, Moal, Florence Dastot - Le, Copin, Bruno, Carion, Nathalie, Louis, Bruno, Chantot-Bastaraud, Sandra, Siffroi, Jean-Pierre, Mitri, Rana, Coste, André, Escudier, Estelle, and Thouvenin, Guillaume
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Background Primary ciliary dyskinesia (PCD) is a rare airway disorder caused by defective motile cilia. Only male patients have been reported with pathogenic mutations in X-linked DNAAF6, which result in the absence of ciliary dynein arms, whereas their heterozygous mothers are supposedly healthy. Our objective was to assess the possible clinical and ciliary consequences of X-chromosome inactivation (XCI) in these mothers. Methods XCI patterns of six mothers of male patients with DNAAF6-related PCD were determined by DNA-methylation studies and compared with their clinical phenotype (6/6 mothers), as well as their ciliary phenotype (4/6 mothers), as assessed by immunofluorescence and high-speed videomicroscopy analyses. The mutated X chromosome was tracked to assess the percentage of cells with a normal inactivated DNAAF6 allele. Results The mothers' phenotypes ranged from absence of symptoms to mild/moderate or severe airway phenotypes, closely reflecting their XCI pattern. Analyses of the symptomatic mothers' airway ciliated cells revealed the coexistence of normal cells and cells with immotile cilia lacking dynein arms, whose ratio closely mirrored their XCI pattern. Conclusion This study highlights the importance of searching for heterozygous pathogenic DNAAF6 mutations in all female relatives of male PCD patients with a DNAAF6 defect, as well as in females consulting for mild chronic respiratory symptoms. Our results also demonstrate that about one-third--ranging from 20% to 50%--normal ciliated airway cells sufficed to avoid severe PCD, a result paving the way for gene therapy. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Covid-19 outbreak: does the use of a surgical mask impact the sense of smell? A crossover prospective comparative study
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Hyvrard, Clémentine, primary, Petitjean, Margaux, additional, Fieux, Maxime, additional, Zerah-Lancner, Françoise, additional, Coste, André, additional, and Bartier, Sophie, additional
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- 2024
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8. Contribution of endoscopy in high sinus inclusions, a case report
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Moreau Santos Gabriel, Pajot Thomas, Dutrieux Noémie, Malheiro Emeline, Safaa Asmandar, Bequignon Emilie, and Coste André
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third molar ,maxillary sinus ,wisdom tooth ,endoscopy ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Introduction: This paper will discuss the management of iatrogenic displacement of the third molar (3M) into the maxillary sinus through a specific case that we have encountered. Observation: This case reports the atypical clinical history of an ectopic intra sinusal 3M of iatrogenic origin, associated with an inflammatory cyst. A 52-year-old man presented with chronic sinusitis and an oral-sinus communication 30 yr after the displacement of his 3M into the maxillary sinus. A minimally invasive multidisciplinary management using endoscopy was proposed to the patient as well as an 18-month follow-up reporting a normalization of his initial sinus symptoms. Discussion: An analysis of the literature concerning intra sinusal teeth was carried out, whatever their etiology, in order to situate our case and to be able to propose the least invasive procedure for these patients. The different surgical approaches are analyzed as well as the effectiveness of a multidisciplinary management. Conclusion: In this case, the simultaneous oral and nasal approach enabled a minimally invasive procedure. The endoscope is now part of the surgeon's therapeutic arsenal, and the training of practitioners in its use could greatly facilitate procedures.
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- 2023
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9. The Prognostic Value of Olfactory Dysfunction in Patients with COVID-19: The COVIDORA Study.
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Hamel, Anne-Laure, Delbos, Léo, Natella, Pierre-André, Radulesco, Thomas, Alexandru, Mihaela, Bartaire, Emmanuel, Bartier, Sophie, Benoite, Gonda, Bequignon, Emilie, Castillo, Laurent, Canouï-Poitrine, Florence, Carsuzaa, Florent, Corré, Alain, Coste, André, Couloigner, Vincent, Daveau, Clémentine, De Boissieu, Paul, De Bonnecaze, Guillaume, De Gabory, Ludovic, and Debry, Christian
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COVID-19 ,PROGNOSIS ,SMELL disorders ,PUBLIC hospitals ,HOSPITAL admission & discharge - Abstract
Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission). Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing. During the first wave of the pandemic, from 6 April to 11 May 2020, all patients tested positive for COVID-19 confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days of symptom onset. The main outcome measures were the evolution of medical management (out-patient care, standard hospital admission, and ICU admission) at diagnosis and along the clinical course of COVID-19 disease. Results: Among 481 patients included, the prevalence of OD was 60.7%, and it affected mostly female patients (74.3%) under 65 years old (92.5%), with fewer comor-bidities than patients with normal olfactory function. Here, 99.3% (290/292) of patients with OD presented with non-severe COVID-19 disease. Patients reporting OD were significantly less hospi-talized than the ones managed as outpatients, in either a standard medical unit or an ICU. Conclu-sions: As regards the clinical course of COVID-19 disease, OD could predict a decreased risk of hospitalization during the first wave of the pandemic. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Nasal response to stress test in healthy subjects: an experimental pilot study
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De Kermadec, Heloïse, Bequignon, Emilie, Zerah-Lancner, Francoise, Garin, Antoine, Devars du Mayne, Marie, Coste, André, Louis, Bruno, and Papon, Jean-François
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- 2019
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11. Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction
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Bequignon, Emilie, Mangin, David, Bécaud, Justine, Pasquier, Jennifer, Angely, Christelle, Bottier, Mathieu, Escudier, Estelle, Isabey, Daniel, Filoche, Marcel, Louis, Bruno, Papon, Jean-François, and Coste, André
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- 2020
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12. Oncostatin M Contributes to Airway Epithelial Cell Dysfunction in Chronic Rhinosinusitis with Nasal Polyps
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Carsuzaa, Florent, primary, Bequignon, Emilie, additional, Bartier, Sophie, additional, Coste, André, additional, Dufour, Xavier, additional, Bainaud, Matthieu, additional, Lecron, Jean Claude, additional, Louis, Bruno, additional, Tringali, Stéphane, additional, Favot, Laure, additional, and Fieux, Maxime, additional
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- 2023
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13. Chronic Rhinosinusitis Outcome Registry (CHRINOSOR):Establishment of an International Outcome Registry Driven by mHealth Technology
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Seys, Sven F., Hellings, Peter W., Alobid, Isam, Backer, Vibeke, Bequignon, Emilie, von Buchwald, Christian, Cavaliere, Carlo, Coste, André, Deneyer, Lauren, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Gane, Simon, Gevaert, Philippe, Holbaek-Haase, Christiane, Holzmeister, Clemens, Hopkins, Claire, Hox, Valérie, Huart, Caroline, Jankowski, Roger, Jorissen, Mark, Kjeldsen, Anette, Knipps, Lisa, Lange, Bibi, van der Lans, Rik, Laulajainen-Hongisto, Anu, Larsen, Kenneth, Liu, David T., Lund, Valerie, Mariën, Gert, Masieri, Simonetta, Mortuaire, Geoffrey, Mullol, Joaquim, Reitsma, Sietze, Rombaux, Philippe, Schneider, Sven, Steinsvik, Andreas, Tomazic, Peter Valentin, Toppila-Salmi, Sanna K., Van Gerven, Laura, Van Zele, Thibaut, Virkkula, Paula, Wagenmann, Martin, Bachert, Claus, Seys, Sven F., Hellings, Peter W., Alobid, Isam, Backer, Vibeke, Bequignon, Emilie, von Buchwald, Christian, Cavaliere, Carlo, Coste, André, Deneyer, Lauren, Diamant, Zuzana, Eckl-Dorna, Julia, Fokkens, Wytske J., Gane, Simon, Gevaert, Philippe, Holbaek-Haase, Christiane, Holzmeister, Clemens, Hopkins, Claire, Hox, Valérie, Huart, Caroline, Jankowski, Roger, Jorissen, Mark, Kjeldsen, Anette, Knipps, Lisa, Lange, Bibi, van der Lans, Rik, Laulajainen-Hongisto, Anu, Larsen, Kenneth, Liu, David T., Lund, Valerie, Mariën, Gert, Masieri, Simonetta, Mortuaire, Geoffrey, Mullol, Joaquim, Reitsma, Sietze, Rombaux, Philippe, Schneider, Sven, Steinsvik, Andreas, Tomazic, Peter Valentin, Toppila-Salmi, Sanna K., Van Gerven, Laura, Van Zele, Thibaut, Virkkula, Paula, Wagenmann, Martin, and Bachert, Claus
- Abstract
Background: Real-world evidence (RWE) is a valuable instrument to better understand the patient journey and effectiveness of therapies. RWE on the prevalence of uncontrolled chronic rhinosinusitis (CRS) and CRS natural course of disease across Europe is scarce. In addition, there is limited RWE that enables comparison of the effectiveness of marketed therapies including topical or systemic corticosteroids, sinus surgery, or biologics. Objective: To establish an international CHRonic rhINOSinusitis Outcome Registry (CHRINOSOR) based on real-world data collection enabled by mobile health technology. Methodology: A digital platform, Galenus Health, supporting patients and physicians in the management of chronic respiratory diseases, is used to collect data on patient profile, disease history, patient outcomes, and a set of relevant clinical outcomes. Adult patients with a diagnosis of CRS are eligible for inclusion. Results: A collaborative scientific network of 17 university ear-nose-throat (ENT) clinics from 10 European countries has been established with the aim to collect real-world data in a longitudinal and standardized manner. The Galenus Health digital platform is currently being implemented in these ENT clinics taking into account legal, privacy, and data security aspects. Up to 300 patients have already been included. Conclusions: CHRINOSOR is a collaborative effort that aims at improving our understanding of CRS, its comorbidities, and the effectiveness of its treatments. Ultimately, these insights will guide us as scientific community to develop future care pathways informed by RWE.
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- 2023
14. Apalutamide Prevents SARS-CoV-2 Infection in Lung Epithelial Cells and in Human Nasal Epithelial Cells
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Majidipur, Amene, primary, Morin-Dewaele, Margot, additional, Gaspar Lopes, Jeanne, additional, Berry, Francois, additional, Fouchet, Julien, additional, Bartier, Sophie, additional, Dufros Duval, Anais, additional, Soyeux, Pascale, additional, Huet, Eric, additional, Louis, Bruno, additional, Coste, André, additional, Béquignon, Émilie, additional, Saldana, Carolina, additional, Le Corvoisier, Philippe, additional, Destouches, Damien, additional, Pawlotsky, Jean-Michel, additional, de la Taille, Alexandre, additional, Vacherot, Francis, additional, Bruscella, Patrice, additional, and Firlej, Virginie, additional
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- 2023
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15. Additional file 2 of Guided Self-rehabilitation Contract vs conventional therapy in chronic peripheral facial paresis: VISAGE, a multicenter randomized controlled trial
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Baude, Marjolaine, Guihard, Marina, Gault-Colas, Caroline, Bénichou, Ludovic, Coste, André, Méningaud, Jean-Paul, Schmitz, David, Natella, Pierre-André, Audureau, Etienne, and Gracies, Jean-Michel
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Additional file 2: Appendix B. Rehabilitation booklet of the guided-self rehabilitation group.
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- 2023
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16. Additional file 3 of Guided Self-rehabilitation Contract vs conventional therapy in chronic peripheral facial paresis: VISAGE, a multicenter randomized controlled trial
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Baude, Marjolaine, Guihard, Marina, Gault-Colas, Caroline, Bénichou, Ludovic, Coste, André, Méningaud, Jean-Paul, Schmitz, David, Natella, Pierre-André, Audureau, Etienne, and Gracies, Jean-Michel
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Additional file 3: Appendix C. Rehabilitation booklet of the conventional therapy group.
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- 2023
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17. Additional file 1 of Guided Self-rehabilitation Contract vs conventional therapy in chronic peripheral facial paresis: VISAGE, a multicenter randomized controlled trial
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Baude, Marjolaine, Guihard, Marina, Gault-Colas, Caroline, Bénichou, Ludovic, Coste, André, Méningaud, Jean-Paul, Schmitz, David, Natella, Pierre-André, Audureau, Etienne, and Gracies, Jean-Michel
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Additional file 1: Appendix A. Study information and consent form.
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- 2023
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18. Chronic Rhinosinusitis Outcome Registry (CHRINOSOR): Establishment of an International Outcome Registry Driven by mHealth Technology
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Seys, Sven F., primary, Hellings, Peter W., additional, Alobid, Isam, additional, Backer, Vibeke, additional, Bequignon, Emilie, additional, von Buchwald, Christian, additional, Cavaliere, Carlo, additional, Coste, André, additional, Deneyer, Lauren, additional, Diamant, Zuzana, additional, Eckl-Dorna, Julia, additional, Fokkens, Wytske J., additional, Gane, Simon, additional, Gevaert, Philippe, additional, Holbaek-Haase, Christiane, additional, Holzmeister, Clemens, additional, Hopkins, Claire, additional, Hox, Valérie, additional, Huart, Caroline, additional, Jankowski, Roger, additional, Jorissen, Mark, additional, Kjeldsen, Anette, additional, Knipps, Lisa, additional, Lange, Bibi, additional, van der Lans, Rik, additional, Laulajainen-Hongisto, Anu, additional, Larsen, Kenneth, additional, Liu, David T., additional, Lund, Valerie, additional, Mariën, Gert, additional, Masieri, Simonetta, additional, Mortuaire, Geoffrey, additional, Mullol, Joaquim, additional, Reitsma, Sietze, additional, Rombaux, Philippe, additional, Schneider, Sven, additional, Steinsvik, Andreas, additional, Tomazic, Peter-Valentin, additional, Toppila-Salmi, Sanna K., additional, Van Gerven, Laura, additional, Van Zele, Thibaut, additional, Virkkula, Paula, additional, Wagenmann, Martin, additional, and Bachert, Claus, additional
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- 2022
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19. Proviral role of human respiratory epithelial cell‐derived small extracellular vesicles in SARS‐CoV‐2 infection
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Berry, François, primary, Morin‐Dewaele, Margot, additional, Majidipur, Amene, additional, Jamet, Thibaud, additional, Bartier, Sophie, additional, Ignjatovic, Eva, additional, Toniutti, Donatella, additional, Gaspar Lopes, Jeanne, additional, Soyeux‐Porte, Pascale, additional, Maillé, Pascale, additional, Saldana, Carolina, additional, Brillet, Rozenn, additional, Ahnou, Nazim, additional, Softic, Laurent, additional, Couturaud, Benoit, additional, Huet, Éric, additional, Ahmed‐Belkacem, Abdelhakim, additional, Fourati, Slim, additional, Louis, Bruno, additional, Coste, André, additional, Béquignon, Émilie, additional, de la Taille, Alexandre, additional, Destouches, Damien, additional, Vacherot, Francis, additional, Pawlotsky, Jean‐Michel, additional, Firlej, Virginie, additional, and Bruscella, Patrice, additional
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- 2022
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20. Specific Sinusitis
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Coste, André, Papon, Jean-François, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Anniko, Matti, editor, Bernal-Sprekelsen, Manuel, editor, Bonkowsky, Viktor, editor, Bradley, Patrick J., editor, and Iurato, Salvatore, editor
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- 2010
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21. Mepolizumab for chronic rhinosinusitis with nasal polyps ( SYNAPSE ): In‐depth sinus surgery analysis
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Fokkens, Wytske J., primary, Mullol, Joaquim, additional, Kennedy, David, additional, Philpott, Carl, additional, Seccia, Veronica, additional, Kern, Robert C., additional, Coste, André, additional, Sousa, Ana R., additional, Howarth, Peter H., additional, Benson, Victoria S., additional, Mayer, Bhabita, additional, Yancey, Steve W., additional, Chan, Robert, additional, and Gane, Simon B., additional
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- 2022
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22. The disease-specific clinical trial network for primary ciliary dyskinesia: PCD-CTN
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Raidt, Johanna, primary, Maitre, Bernard, additional, Pennekamp, Petra, additional, Altenburg, Josje, additional, Anagnostopoulou, Pinelopi, additional, Armengot, Miguel, additional, Bloemsma, Lizan D., additional, Boon, Mieke, additional, Borrelli, Melissa, additional, Brinkmann, Folke, additional, Carr, Siobhan B., additional, Carroll, Mary P., additional, Castillo-Corullón, Silvia, additional, Coste, André, additional, Cutrera, Renato, additional, Dehlink, Eleonora, additional, Destouches, Damien M.S., additional, Di Cicco, Maria E., additional, Dixon, Lucy, additional, Emiralioglu, Nagehan, additional, Erdem Eralp, Ela, additional, Haarman, Eric G., additional, Hogg, Claire, additional, Karadag, Bulent, additional, Kobbernagel, Helene E., additional, Lorent, Natalie, additional, Mall, Marcus A., additional, Marthin, June K., additional, Martinu, Vendula, additional, Narayanan, Manjith, additional, Ozcelik, Ugur, additional, Peckham, Daniel, additional, Pifferi, Massimo, additional, Pohunek, Petr, additional, Polverino, Eva, additional, Range, Simon, additional, Ringshausen, Felix C., additional, Robson, Evie, additional, Roehmel, Jobst, additional, Rovira-Amigo, Sandra, additional, Santamaria, Francesca, additional, Schlegtendal, Anne, additional, Szépfalusi, Zsolt, additional, Tempels, Petra, additional, Thouvenin, Guillaume, additional, Ullmann, Nicola, additional, Walker, Woolf T., additional, Wetzke, Martin, additional, Yiallouros, Panayiotis, additional, Omran, Heymut, additional, and Nielsen, Kim G., additional
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- 2022
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23. Physiology of the Nose
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Papon, Jean-François, Coste, André, Arnold, Wolfgang, editor, Ganzer, Uwe, editor, Anniko, Matti, editor, Bernal-Sprekelsen, Manuel, editor, Bonkowsky, Viktor, editor, Bradley, Patrick J., editor, and Iurato, Salvatore, editor
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- 2010
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24. The disease-specific clinical trial network for primary ciliary dyskinesia:PCD-CTN
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Raidt, Johanna, Maitre, Bernard, Pennekamp, Petra, Altenburg, Josje, Anagnostopoulou, Pinelopi, Armengot, Miguel, Bloemsma, Lizan D., Boon, Mieke, Borrelli, Melissa, Brinkmann, Folke, Carr, Siobhan B., Carroll, Mary P., Castillo-Corullón, Silvia, Coste, André, Cutrera, Renato, Dehlink, Eleonora, Destouches, Damien M.S., Di Cicco, Maria E., Dixon, Lucy, Emiralioglu, Nagehan, Eralp, Ela Erdem, Haarman, Eric G., Hogg, Claire, Karadag, Bulent, Kobbernagel, Helene E., Lorent, Natalie, Mall, Marcus A., Marthin, June K., Martinu, Vendula, Narayanan, Manjith, Ozcelik, Ugur, Peckham, Daniel, Pifferi, Massimo, Pohunek, Petr, Polverino, Eva, Range, Simon, Ringshausen, Felix C., Robson, Evie, Roehmel, Jobst, Rovira-Amigo, Sandra, Santamaria, Francesca, Schlegtendal, Anne, Szépfalusi, Zsolt, Tempels, Petra, Thouvenin, Guillaume, Ullmann, Nicola, Walker, Woolf T., Wetzke, Martin, Yiallouros, Panayiotis, Omran, Heymut, Nielsen, Kim G., Raidt, Johanna, Maitre, Bernard, Pennekamp, Petra, Altenburg, Josje, Anagnostopoulou, Pinelopi, Armengot, Miguel, Bloemsma, Lizan D., Boon, Mieke, Borrelli, Melissa, Brinkmann, Folke, Carr, Siobhan B., Carroll, Mary P., Castillo-Corullón, Silvia, Coste, André, Cutrera, Renato, Dehlink, Eleonora, Destouches, Damien M.S., Di Cicco, Maria E., Dixon, Lucy, Emiralioglu, Nagehan, Eralp, Ela Erdem, Haarman, Eric G., Hogg, Claire, Karadag, Bulent, Kobbernagel, Helene E., Lorent, Natalie, Mall, Marcus A., Marthin, June K., Martinu, Vendula, Narayanan, Manjith, Ozcelik, Ugur, Peckham, Daniel, Pifferi, Massimo, Pohunek, Petr, Polverino, Eva, Range, Simon, Ringshausen, Felix C., Robson, Evie, Roehmel, Jobst, Rovira-Amigo, Sandra, Santamaria, Francesca, Schlegtendal, Anne, Szépfalusi, Zsolt, Tempels, Petra, Thouvenin, Guillaume, Ullmann, Nicola, Walker, Woolf T., Wetzke, Martin, Yiallouros, Panayiotis, Omran, Heymut, and Nielsen, Kim G.
- Abstract
Primary ciliary dyskinesia (PCD) is a rare genetic disorder characterised by impaired mucociliary clearance leading to irreversible lung damage. In contrast to other rare lung diseases like cystic fibrosis (CF), there are only few clinical trials and limited evidence-based treatments. Management is mainly based on expert opinions and treatment is challenging due to a wide range of clinical manifestations and disease severity. To improve clinical and translational research and facilitate development of new treatments, the clinical trial network for PCD (PCD-CTN) was founded in 2020 under the framework of the European Reference Network (ERN)-LUNG PCD Core. Applications from European PCD sites interested in participating in the PCD-CTN were requested. Inclusion criteria consisted of patient numbers, membership of ERN-LUNG PCD Core, use of associated standards of care, experience in PCD and/or CF clinical research, resources to run clinical trials, good clinical practice (GCP) certifications and institutional support. So far, applications from 22 trial sites in 18 European countries have been approved, including >1400 adult and >1600 paediatric individuals with PCD. The PCD-CTN is headed by a coordinating centre and consists of a steering and executive committee, a data safety monitoring board and committees for protocol review, training and standardisation. A strong association with patient organisations and industrial companies are further cornerstones. All participating trial sites agreed on a code of conduct. As CTNs from other diseases have demonstrated successfully, this newly formed PCD-CTN operates to establish evidence-based treatments for this orphan disease and to bring new personalised treatment approaches to patients.
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- 2022
25. Clinical characteristics, functional respiratory decline and follow-up in adult patients with primary ciliary dyskinesia
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Frija-Masson, Justine, Bassinet, Laurence, Honoré, Isabelle, Dufeu, Nadine, Housset, Bruno, Coste, André, Papon, Jean Francois, Escudier, Estelle, Burgel, Pierre-Régis, and Maître, Bernard
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- 2017
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26. Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): In‐depth sinus surgery analysis.
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Fokkens, Wytske J., Mullol, Joaquim, Kennedy, David, Philpott, Carl, Seccia, Veronica, Kern, Robert C., Coste, André, Sousa, Ana R., Howarth, Peter H., Benson, Victoria S., Mayer, Bhabita, Yancey, Steve W., Chan, Robert, and Gane, Simon B.
- Subjects
ENDOSCOPIC surgery ,NASAL polyps ,CLINICAL trials ,SINUSITIS ,SYNAPSES ,REOPERATION - Abstract
Background: Patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) often require repeat sinus surgery. Mepolizumab reduced the need for sinus surgery in the SYNAPSE trial; this analysis sought to provide a more in‐depth assessment of surgery endpoints in SYNAPSE. Methods: SYNAPSE was a double‐blind Phase III trial (NCT03085797) in adults with recurrent, refractory, severe, CRSwNP eligible for repeat sinus surgery despite standard of care treatments and previous surgery. Patients were randomized (1:1) to mepolizumab 100 mg subcutaneously or placebo, plus standard of care, every 4 weeks for 52 weeks. Time to first inclusion on a waiting list for sinus surgery and time to first actual sinus surgery (both up to week 52) were assessed; the latter endpoint was also analyzed post hoc according to time since last sinus surgery before study screening and baseline blood eosinophil count. Results: Among 407 patients (mepolizumab: 206; placebo: 201), mepolizumab versus placebo reduced the risk of being included on a waiting list for sinus surgery (week 52 Kaplan–Meier probability estimate [95% confidence interval]: 13.9% [9.8%, 19.5%] vs. 28.5% [22.7%, 35.4%]). Mepolizumab versus placebo reduced the risk of sinus surgery irrespective of time (<3 vs ≥3 years) since patients' last sinus surgery prior to study screening (hazard ratios [95% confidence intervals] 0.28 [0.09, 0.84] and 0.50 [0.26, 0.98], respectively) and baseline blood eosinophil count. Conclusions: Mepolizumab reduced the risk of further sinus surgery in patients with recurrent, refractory, severe CRSwNP, irrespective of the patient baseline characteristics assessed. [ABSTRACT FROM AUTHOR]
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- 2023
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27. COVID‐19 pandemic: do surgical masks impact respiratory nasal functions?
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Petitjean, Margaux, primary, Béquignon, Émilie, additional, Fieux, Maxime, additional, Louis, Bruno, additional, Zerah, Françoise, additional, Coste, André, additional, and Bartier, Sophie, additional
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- 2022
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28. Covid-19 outbreak: does the use of a surgical mask impact the sense of smell?
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Hyvrard, Clémentine, primary, Petitjean, Margaux, additional, Fieux, Maxime, additional, Zerah, Françoise, additional, Coste, André, additional, and Bartier, Sophie, additional
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- 2022
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29. Dégradation de l'enseignement notée par les internes d’Oto-rhino-laryngologie français au cours de la pandémie de Covid-19; analyse STROBE
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Alexandru, Mihaela, primary, Favier, Valentin, additional, Coste, André, additional, Carsuzaa, Florent, additional, Fieux, Maxime, additional, Fath, Léa, additional, and Bartier, Sophie, additional
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- 2022
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30. TTC12 loss-of-function mutations cause primary ciliary dyskinesia and unveil distinct dynein assemblymechanisms in motile cilia versus flagella
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THOMAS, Lucie, Bouhouche, Khaled, Whitfield, Marjorie, Thouvenin, Guillaume, Coste, André, Louis, Bruno, Szymanski, Claire, Bequignon, Emilie, Papon, Jean-François, Castelli, Manon, Lemullois, Michel, Dhalluin, Xavier, Drouin-Garraud, Valérie, Montantin, Guy, Tissier, Sylvie, Duquesnoy, Philippe, Copin, Bruno, Dastot - Le Moal, Florence, Couvet, Sandrine, Barbotin, Anne Laure, Faucon, Catherine, Honoré, Isabelle, Maitre, Bernard, Beydon, Nicole, Tamalet, Aline, Rives, Nathalie, Koll, France, Escudier, Estelle, Tassin, Anne-Marie, Touré, Aminata, Mitchell, Valerie, Amselem, Serge, Legendre, Marie, Couvet, Sandrine, Maladies génétiques d'expression pédiatrique (U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Gif-sur-Yvette, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Hôpital Trousseau, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Intercommunal de Créteil (CHIC), IMRB - 'Biomechanics and Respiratory Apparatus' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'ORL et de Chirurgie Cervico-Faciale (LILLE - ORL et CCF), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d’ORL et de chirurgie cervico-faciale [CHU Le Kremlin-Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Clinique de pneumologie [CHRU Lille], Service de génétique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Department of Reproductive Biology and Spermiology-CECOS Lille, University Medical Center, Lille, 59037, France., Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de pneumologie [CHU Cochin], Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies génétiques d'expression pédiatrique [CHU Trousseau] (Inserm U933), and UF de Génétique moléculaire [CHU Trousseau]
- Subjects
dynein arm assembly ,[SDV] Life Sciences [q-bio] ,[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics ,[SDV]Life Sciences [q-bio] ,cilia ,primary ciliary dyskinesia ,CRISPR-Cas9 ,[SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics ,TTC12 ,sperm flagella - Abstract
International audience; Cilia and flagella are evolutionarily conserved organelles whose motility relies on the outer and inner dynein arm complexes (ODAs/IDAs). Defects in ODAs/IDAs result in primary ciliary dyskinesia (PCD), a disease characterized by recurrent airway infections and male infertility. To date PCD mutations in assembly factors cause a combined ODA/IDA defect, affecting both cilia and flagella. We identified four loss-of-function mutations in TTC12, which encodes a cytoplasmic protein, in four independent families in which affected individuals displayed a peculiar PCD phenotype characterized by the absence of ODAs and IDAs in sperm flagella, contrasting with the sole absence of IDAs in respiratory cilia. We analysed both primary cells from individuals carrying TTC12 mutations and human differentiated airway cells invalidated for TTC12 by a CRISPR-Cas9 approach, as well as TTC12 depletion in the ciliated model, Paramecium tetraureli. Our results revealed an IDA defect restricted to a subset of single-headed IDAs different in flagella and cilia, while TTC12 depletion in Paramecium tetraurelia recapitulated the sperm phenotype. Overall, our study, which identifies TTC12 as a new gene involved in PCD, unveils distinct dynein assembly mechanisms in human motile cilia versus flagella.
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- 2022
31. Sublabial bioactive glass implantation for the management of primary atrophic rhinitis and empty nose syndrome: Operative technique
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Hassan, Charles‐Henri, primary, Malheiro, Emeline, additional, Béquignon, Emilie, additional, Coste, André, additional, and Bartier, Sophie, additional
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- 2021
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32. Frontal sinus obliteration with autologous calvarial bone graft: indications and results
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Vironneau, Pierre, Coste, André, and Prulière-Escabasse, Virginie
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- 2014
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33. Determinants of respiratory function in adult patients with primary ciliary dyskinesia: PO.076
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Frija-Masson, Justine, Bassinet, Laurence, Honore, Isabelle, Desmazes-Dufeu, Nadine, Housset, Bruno, Coste, André, Papon, Jean-François, Escudier, Estelle, Burgel, Pierre-Régis, and Maitre, Bernard
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- 2016
34. Otitis media in severe asthma associated with chronic rhinosinusitis with nasal polyps: a new therapeutic target for biologics.
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Bartier, Sophie, Béquignon, Emilie, Thibaut de Ménonville, Charlotte, Verillaud, Benjamin, Evrard, Diane, Léger, Maëlys, Papon, Jean-François, Coste, André, and Taillé, Camille
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NASAL polyps ,OTITIS media ,OTITIS media with effusion ,SINUSITIS ,ASTHMA ,BIOLOGICALS - Abstract
Background: Chronic rhinosinusitis with nasal polyps (CRSwNPs) is associated with otitis media with effusion (OME) in about 25% of cases. The objective of this study was to assess the clinical efficacy of the 4 biologic agents currently available in France for severe asthma (omalizumab, mepolizumab, benralizumab and dupilumab) in 17 patients followed for both asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and presenting otitis media with effusion (OME) on otoscopy. Methods: It was a multicenter retrospective study performed in 4 academic ENT and respiratory departments in Paris, France, with assessment of the clinical evolution of 17 patients with severe eosinophilic asthma and with chronic refractory OME and CRSwNPs treated by biologic agents. Global evaluation of treatment effectiveness (GETE) on asthma, CRSwNP and OME was classified on a 5-point scale as 1, excellent; 2, good; 3, moderate; 4, poor; or 5, symptoms worsening. Response was defined as an excellent/good score (1 or 2). Results: 17 patients were prescribed a total of 30 biologics. The evolution of OME did not follow that of asthma and CRSwNPs in 15 (88%) and 12 (70%) cases, respectively. Concerning OME, 19/30 (63%) patients were non-responders. Among the 10 patients who successively received ≥ 2 biologic agents, the OME response differed, depending on the considered agent Dupilumab had the highest response rate. Conclusions: Resistant OME, associated with asthma and chronic rhinosinusitis with nasal polyps, can present a disconnected evolution under biologics. CRSwNP-associated OME requires a specific evaluation to define the best treatment. [ABSTRACT FROM AUTHOR]
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- 2023
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35. Chapitre 5 - Lymphomes NK/T extraganglionnaires de type nasal: Aspects cliniques et prise en charge, liens avec l'EBV
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Béquignon, Émilie, Bartier, Sophie, and Coste, André
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- 2021
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36. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Ear, Nose, and Throat Description at Acute Stage and After Remission
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Bequignon, Emilie, Duong, Tu Anh, Sbidian, Emilie, Valeyrie-Allanore, Laurence, Ingen-Housz-Oro, Saskia, Chatelin, Veronique, Coste, André, Wolkenstein, Pierre, Chosidow, Olivier, and Papon, Jean François
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- 2015
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37. FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review
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Fieux, Maxime, primary, Le Quellec, Sandra, additional, Bartier, Sophie, additional, Coste, André, additional, Louis, Bruno, additional, Giroudon, Caroline, additional, Nourredine, Mikail, additional, and Bequignon, Emilie, additional
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- 2021
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38. Comparative study of four radiofrequency generators for the treatment of snoring
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Blumen, Marc B., Chalumeau, Frédéric, Gauthier, Anne, Bobin, Serge, Coste, André, and Chabolle, Frédéric
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- 2008
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39. In Vitro Experiments and Numerical Simulations of Airflow in Realistic Nasal Airway Geometry
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Croce, Céline, Fodil, Redouane, Durand, Marc, Sbirlea-Apiou, Gabriela, Caillibotte, Georges, Papon, Jean-François, Blondeau, Jean-Robert, Coste, André, Isabey, Daniel, and Louis, Bruno
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- 2006
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40. Is diet partly responsible for differences in COVID-19 death rates between and within countries?
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Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zubrinich, Celia, Bousquet, Jean, Anto, Josep M., Iaccarino, Guido, Czarlewski, Wienczyslawa, Haahtela, Tari, Anto, Aram, Akdis, Cezmi, Blain, Hubert, Canonica, G. Walter, Cardona, Victoria, Cruz, Alvaro A., Illario, Maddalena, Ivancevich, Juan Carlos, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Larenas-linnemann, Désirée, Mullol, Joaquim, Papadopoulos, Nikos G., Pfaar, Oliver, Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Zuberbier, Torsten, Latiff, Amir, Abdullah, Baharudin, Aberer, Werner, Abusada, Nancy, Adcock, Ian, Afani, Alejandro, Agache, Ioana, Aggelidis, Xenofon, Agustin, Jenifer, Akdis, Mübeccel, Al-Ahmad, Mona, Bassam, Abou Al Zahab, Aldrey-Palacios, Oscar, Cuesta, Emilio Alvarez, Alzaabi, Ashraf, Amad, Salma, Ambrocio, Gene, Annesi-Maesano, Isabella, Ansotegui, Ignacio, Anto, Josep, Arshad, Hasan, Artesani, Maria Cristina, Asayag, Estrella, Avolio, Francesca, Azhari, Khuzama, Baiardini, Ilaria, Bajrović, Nissera, Bakakos, Petros, Mongono, Sergio Bakeyala, Balotro-Torres, Christine, Barba, Sergio, Barbara, Cristina, Barbosa, Elsa, Barreto, Bruno, Bartra, Joan, Bateman, Eric D., Battur, Lkhagvaa, Bedbrook, Anna, Barajas, Martín Bedolla, Beghé, Bianca, Bel, Elizabeth, Kheder, Ali Ben, Benson, Mikael, Berghea, Camelia, Bergmann, Karl Christian, Bernstein, David, Bewick, Mike, Bialek, Slawomir, Białoszewski, Artur, Bieber, Thomas, Billo, Nils, Bilo, Maria Beatrice, Bindslev-Jensen, Carsten, Bjermer, Leif, Marciniak, Malgorzata Bochenska, Bond, Christine, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Botskariova, Sofia, Bouchard, Jacques, Boulet, Louis Philippe, Bourret, Rodolphe, Bousquet, Philippe, Braido, Fulvio, Briggs, Andrew, Brightling, Christopher, Brozek, Jan, Buhl, Roland, Bumbacea, Roxana, Cabañas, María Teresa Burguete, Bush, Andrew, Busse, William W., Buters, Jeroen, Caballero-Fonseca, Fernan, Calderon, Moïses A., Calvo, Mario, Camargos, Paulo, Camuzat, Thierry, Cano, Antonio, Capriles-Hulett, Arnaldo, Caraballo, Luis, Cardona, Vicky, Carlsen, Kai Hakon, Caro, Jorge, Carreon-Asun-cion, Fredelita, Carriazo, Ana Maria, Casale, Thomas, Castor, Mary Ann, Castro, Elizabeth, Cecchi, Lorenzo, Sarabia, Alfonso Cepeda, Chandrasekharan, Ramanathan, Chang, Yoon Suk, Chato-Andeza, Victoria, Chatzi, Lida, Chatzidaki, Christina, Chavannes, Niels H., Chen, Yuzhi, Cheng, Lei, Chivato, Tomas, Chkhartishvili, Ekaterine, Christoff, George, Chrystyn, Henry, Chu, Derek K., Chua, Antonio, Chuchalin, Alexander, Chung, Kian Fan, Cicerán, Alberto, Cingi, Cemal, Ciprandi, Giorgio, Cirule, Ieva, Coelho, Ana Carla, Constantinidis, Jannis, de Sousa, Jaime Correia, Costa, Elisio, Costa, David, Domínguez, María Del Carmen Costa, Coste, André, Cox, Linda, Cullen, John, Custovic, Adnan, Cvetkovski, Biljana, D’amato, Gennaro, Silva, Jane da, Dahl, Ronald, Dahlen, Sven Erik, Daniilidis, Vasilis, Nahhas, Louei Darjazini, Darsow, Ulf, Blay, Frédéric de, Guia, Eloisa De, Santos, Chato de los, Keenoy, Esteban De Manuel, Vries, Govert De, Deleanu, Diana, Demoly, Pascal, Denburg, Judah, Devillier, Philippe, Didier, Alain, Dimou, Maria, Dinh-Xuan, Anh Tuan, Djukanovic, Ratko, Dokic, Dejan, Domínguez Silva, Margarita Gabriela, Douagui, Habib, Douladiris, Nikolaos, Doulaptsi, Maria, Dray, Gérard, Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, Ebo, Didier, Edelbaher, Natalija, Eklund, Patrik, El-Gamal, Yehia, El-Sayed, Zeinab A., El-Sayed, Shereen S., El-Seify, Magda, Emuzyte, Regina, Enecilla, Lourdes, Espinoza, Heidilita, Guillermo, Jesús, Contreras, Espinoza, Farrell, John, Fernandez, Lenora, Wagner, Antje Fink, Fiocchi, Alessandro, Fokkens, Wytske J., Fontaine, Jean François, Forastiere, Francesco, Pèrez, Jose Miguel Fuentes, Gaerlan–resureccion, Emily, Gaga, Mina, Romero, José Luis Gálvez, Gamkrelidze, Amiran, Garcia, Alexis, Cobas, Cecilia Yvonne García, García Cruz, María de la Luz Hortensia, Gayraud, Jacques, Gemicioglu, Bilun, Genova, Sonya, Gereda, José, Wijk, Roy Gerth van, Gomez, Maximiliano, Diaz, Sandra González, Gotua, Maia, Grigoreas, Christos, Grisle, Ineta, Guidacci, Marta, Guldemond, Nick, Gutter, Zdenek, Guzmán, Antonieta, Halloum, Ramsa, Hamelmann, Eckard, Hammadi, Suleiman, Harvey, Richard, Heinrich, Joachim, Hejjaoui, Adnan, Hellquist-Dahl, Birthe, Velázquez, Luiana Hernández, Hew, Mark, Hossny, Elham, Howarth, Peter, Hrubiško, Martin, Villalobos, Yunuen Rocío Huerta, Humbert, Marc, Hyland, Michael, Ibrahim, Moustafa, Ilyina, Natalia, Irani, Carla, Ispayeva, Zhanat, Jares, Edgardo, Jarvis, Deborah, Jassem, Ewa, Jenko, Klemen, Uscanga, Rubén Darío Jiméneracruz, Johnston, Sebastian, Joos, Guy, Jošt, Maja, Julge, Kaja, Jung, Ki Suck, Just, Jocelyne, Kaidashev, Igor, Kalayci, Omer, Kalyoncu, Fuat, Kapsali, Jeni, Kardas, Przemyslaw, Karjalainen, Jussi, Kasala, Carmela A., Katotomichelakis, Michael, Kazi, Bennoor, Keil, Thomas, Keith, Paul, Khaitov, Musa, Khaltaev, Nikolai, Kim, You Young, Kleine-Tebbe, Jorg, Koffi N’Goran, Bernard, Kompoti, Evangelia, Kopač, Peter, Koppelman, Gerard, Jeverica, Anja Koren, Košnik, Mitja, Kostov, Kosta V., Kowalski, Marek L., Kralimarkova, Tanya, Vrščaj, Karmen Kramer, Kraxner, Helga, Kreft, Samo, Kritikos, Vicky, Kudlay, Dmitry, Kull, Inger, Kupczyk, Maciej, Kvedariene, Violeta, Kyriakakou, Marialena, Lalek, Nika, Lane, Stephen, Larenas-Linnemann, Désiree, Lau, Susanne, Lavrut, Jorge, Le, Lan, Lessa, Marcus, Levin, Michael, Li, Jing, Lieberman, Philip, Liotta, Giuseppe, Lipworth, Brian, Liu, Xuandao, Lobo, Rommel, Lodrup Carlsen, Karin C., Lombardi, Carlo, Louis, Renaud, Loukidis, Stelios, Lourenço, Olga, Luna Pech, Jorge A., Madjar, Bojan, Magnan, Antoine, Mahboub, Bassam, Mair, Alpana, Mais, Yassin, van der Zee, Anke Hilse Maitland, Makela, Mika, Makris, Michael, Malling, Hans Jorgen, Mandajieva, Mariana, Manning, Patrick, Manousakis, Manolis, Maragoudakis, Pavlos, Marshall, Gailen, Martins, Pedro, Reza Masjedi, Mohammad, Máspero, Jorge F., Campos, Juan José Matta, Maurer, Marcus, Mavale-Manuel, Sandra, Meço, Cem, Melén, Erik, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Menzies-Gow, Andrew, Merk, Hans, Michel, Jean Pierre, Miculinic, Neven, Midão, Luís, Mihaltan, Florin, Mikael, Kuitunen, Mikos, Nikolaos, Milenkovic, Branislava, Mitsias, Dimitrios, Moalla, Bassem, Moda, Giuliana, Martínez, María Dolores Mogica, Mohammad, Yousser, Moin, Mostafa, Molimard, Mathieu, Momas, Isabelle, Monaco, Alessandro, Montefort, Steve, Mora, Dory, Morais-Almeida, Mario, Mösges, Ralph, Mostafa, Badr Eldin, Münter, Lars, Muraro, Antonella, Murray, Ruth, Mustakov, Tihomir, Naclerio, Robert, Nadif, Rachel, Nakonechna, Alla, Namazova-Baranova, Leyla, Navarro-Locsin, Gretchen, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Nicod, Laurent, Niederberger-Leppin, Verena, Niedoszytko, Marek, Nieto, Antonio, Novellino, Ettore, Nunes, Elizabete, Nyembue, Dieudonné, O’hehir, Robyn, Odjakova, Cvetanka, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Oliver, Brian, Onorato, Gabrielle L., Orru, Maria Pia, Ouédraogo, Solange, Ouoba, Kampadilemba, Paggiaro, Pier Luigi, Pagkalos, Aris, Palaniappan, S. P., Pali-Schöll, Isabella, Palkonen, Susanna, Palmer, Stephen, Bunu, Carmen Panaitescu, Panzner, Petr, Papanikolaou, Vasilis, Papi, Alberto, Paralchev, Bojidar, Paraskevopoulos, Giannis, Park, Hae Sim, Passalacqua, Giovanni, Patella, Vincenzo, Pavord, Ian, Pawankar, Ruby, Pedersen, Soren, Peleve, Susete, Pereira, Ana, Pérez, Tamara, Pham-Thi, Nhân, Pigearias, Bernard, Pin, Isabelle, Piskou, Konstantina, Pitsios, Constantinos, Pitsios, Kostas, Plavec, Davor, Poethig, Dagmar, Pohl, Wolfgang, Susic, Antonija Poplas, Popov, Todor A., Portejoie, Fabienne, Potter, Paul, Poulsen, Lars, Prados-Torres, Alexandra, Prarros, Fotis, Price, David, Prokopakis, Emmanuel, Puy, Robert, Rabe, Klaus, Raciborski, Filip, Ramos, Josephine, Recto, Marysia T., Reda, Shereen M., Regateiro, Frederico, Reider, Norbert, Reitsma, Sietze, Repka-Ramirez, Susana, Rimmer, Janet, Yeverino, Daniela Rivero, Rizzo, José Angelo, Robalo-Cordeiro, Carlos, Roberts, Graham, Roche, Nicolas, González, Mónica Rodríguez, Zagal, Eréndira Rodríguez, Rolland, Christine, Roller-Wirns-berger, Regina, Rodriguez, Miguel Roman, Romano, Antonino, Rombaux, Philippe, Romualdez, Joel, Rosado-Pinto, Jose, Rosario, Nelson, Rosenwasser, Lanny, Rottem, Menachem, Rouadi, Philip, Rovina, Nikoleta, Sinur, Irma Rozman, Ruiz, Mauricio, Segura, Lucy Tania Ruiz, Ryan, Dermot, Sagara, Hironori, Sakai, Daiki, Sakurai, Daiju, Saleh, Wafaa, Salimaki, Johanna, Salina, Husain, Samitas, Konstanti Nos, Coronel, María Guadalupe Sánchez, Sanchez-Borges, Mario, Sanchez-Lopez, Jaime, Sarafoleanu, Codrut, Serpa, Faradiba Sarquis, Sastre-Dominguez, Joaquin, Scadding, Glenis, Scheire, Sophie, Schmid-Grendelmeier, Peter, Schuhl, Juan Francisco, Schunemann, Holger, Schvalbová, Maria, Scichilone, Nicola, Sepúlveda, Cecilia, Serrano, Elie, Sheikh, Aziz, Shields, Mike, Shishkov, Vasil, Siafakas, Nikos, Simeonov, Alexander, Simons, Estelle F., Sisul, Juan Carlos, Sitkauskiene, Brigita, Skrindo, Ingelbjorg, Košak, Tanja Soklič, Solé, Dirceu, Sooronbaev, Talant, Soto-Martinez, Manuel, Sova, Milan, Spertini, François, Spranger, Otto, Stamataki, Sofia, Stefanaki, Lina, Stellato, Cristiana, Stelmach, Rafael, Sterk, Peter, Strandberg, Timo, Stute, Petra, Subramaniam, Abirami, Suppli Ulrik, Charlotte, Sutherland, Michael, Sylvestre, Silvia, Syrigou, Aikaterini, Barata, Luis Taborda, Takovska, Nadejda, Tan, Rachel, Tan, Frances, Tan, Vincent, Tang, Ing Ping, Taniguchi, Masami, Tannert, Line, Tattersall, Jessica, Teixeira, Maria Do Ceu, Thijs, Carel, Thomas, Mike, To, Teresa, Todo-Bom, Ana Maria, Togias, Alkis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna, Toskala, Elina, Triggiani, Massimo, Triller, Nadja, Triller, Katja, Tsiligianni, Ioanna, Ulmeanu, Ruxandra, Urbancic, Jure, Pereira, Marilyn Urrutia, Vachova, Martina, Valdés, Felipe, Valenta, Rudolf, Rostan, Marylin Valentin, Valero, Antonio, Vallianatou, Mina, Valovirta, Erkka, Eerd, Michiel Van, Ganse, Eric Van, Hage, Marianne van, Vandenplas, Olivier, Vasankari, Tuula, Vassileva, Dafina, Ventura, Teresa, Vera-Munoz, Cécilia, Vicheva, Dilyana, Vichyanond, Pakit, Vidgren, Petra, Viegi, Giovanni, Vogelmeier, Claus, Hertzen, Leena Von, Vontetsianos, Theodoros, Vourdas, Dimitris, Wagenmann, Martin, Walker, Samantha, Wallace, Dana, Wang, De Yun, Waserman, Susan, Wickman, Magnus, Williams, Sian, Williams, Dennis, Wilson, Nicola, Woo, Kent, Wright, John, Wroczynski, Piotr, Xepapadaki, Paraskevi, Yakovliev, Plamen, Yamaguchi, Masao, Yan, Kwok, Yap, Yoke Yeow, Yawn, Barbara, Yiallouros, Panayiotis, Yoshihara, Shigemi, Young, Ian, Yusuf, Osman B., Zaidi, Asghar, Zaitoun, Fares, Zar, Heather, Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, and Zubrinich, Celia
- Abstract
Reported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be significant are the dietary habits. It seems that some foods largely used in these countries may reduce angiotensin-converting enzyme activity or are anti-oxidants. Among the many possible areas of research, it might be important to understand diet and angiotensin-converting enzyme-2 (ACE2) levels in populations with different COVID-19 death rates since dietary interventions may be of great benefit.
- Published
- 2020
41. Blessure et réparation épithéliale : une hypothèse physiopathologique de la polypose nasosinusienne
- Author
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Lazard, Diane S., Prulière-Escabasse, Virginie, Papon, Jean-François, Escudier, Estelle, and Coste, André
- Published
- 2007
- Full Text
- View/download PDF
42. Household transmission and incidence of positive SARS-CoV-2 RT-PCR in symptomatic healthcare workers, clinical course and outcome: a French hospital experience
- Author
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Krastinova, Evguenia, primary, Garrait, Valérie, additional, Lecam, Marie-Thérèse, additional, Coste, André, additional, Varon, Emmanuelle, additional, Delacroix, Isabelle, additional, Si Ali, Amine, additional, Jung, Camille, additional, Smati, Mounira, additional, Cherbit, Muriel, additional, Maître, Bernard, additional, Pairon, Jean-Claude, additional, and Andujar, Pascal, additional
- Published
- 2020
- Full Text
- View/download PDF
43. Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia
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Blanchon, Sylvain, Legendre, Marie, Copin, Bruno, Duquesnoy, Philippe, Montantin, Guy, Kott, Esther, Dastot, Florence, Jeanson, Ludovic, Cachanado, Marine, Rousseau, Alexandra, Papon, Jean François, Beydon, Nicole, Brouard, Jacques, Crestani, Bruno, Deschildre, Antoine, Désir, Julie, Dollfus, Hélène, Leheup, Bruno, Tamalet, Aline, Thumerelle, Caroline, Vojtek, Anne-Marie, Escalier, Denise, Coste, André, de Blic, Jacques, Clément, Annick, Escudier, Estelle, and Amselem, Serge
- Published
- 2012
- Full Text
- View/download PDF
44. Polypectomy Compared With Ethmoidectomy in the Treatment of Nasal Polyposis
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Devars du Mayne, Marie, Prulière-Escabasse, Virginie, Zerah-Lancner, Françoise, Coste, André, and Papon, Jean-François
- Published
- 2011
- Full Text
- View/download PDF
45. Rhinitis in Patients Treated with a Combination of an mTOR Inhibitor and an EGFR Inhibitor
- Author
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Prulière-Escabasse, Virginie, Gomez-Roca, Carlos, Escudier, Estelle, Coste, André, Besse, Benjamin, Massard, Christophe, and Soria, Jean-Charles
- Published
- 2010
- Full Text
- View/download PDF
46. Sublabial bioactive glass implantation for the management of primary atrophic rhinitis and empty nose syndrome: Operative technique.
- Author
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Hassan, Charles‐Henri, Malheiro, Emeline, Béquignon, Emilie, Coste, André, and Bartier, Sophie
- Subjects
BIOACTIVE glasses ,TURBINATE bones ,RHINITIS ,NASAL surgery ,NOSE ,NASAL cavity - Abstract
Objectives: Atrophic rhinitis (AR) and empty nose syndrome (ENS) are chronic diseases characterized by a paradoxical nasal obstruction. These rare syndromes tend to occur after nasal surgery of the inferior turbinates in ENS and can be idiopathic in AR. Medical treatments alone are often insufficient. Surgical options are challenging and numerous resorbable and nonresorbable implants have been described in small series, with as many surgical techniques described. Whereas current surgical procedures are for risk of extrusions, graft rejections or poor lasting results, the use of GlassBONE™ (Sodimed®, Avignon, France), a bioactive glass, for a vestibular approach in AR and ENS has never been reported for this indication. Methods: We described an original technique of nasal submucoperiosteal bilateral ceramic glass implantation in two patients with AR and ENS. Results: The two cases presented a postoperative satisfying endoscopic and sinus CT‐scan results with filling of the nasal cavities, with less crusts and a complete wound healing. They had no short‐term complications. Conclusion: This innovative approach is easily feasible and could be an option considered for the surgical management of AR and ENS. Level of evidence: 4. [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
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47. Pathogenesis of chronic rhinosinusitis with nasal polyps: role of IL-6 in airway epithelial cell dysfunction
- Author
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Bequignon, Emilie, Mangin, David, Bécaud, Justine, Pasquier, Jennifer, Angely, Christelle, Bottier, Mathieu, Escudier, Estelle, Isabey, Daniel, Filoche, Marcel, Louis, Bruno, Papon, Jean-François, Coste, André, Laboratoire de physique de la matière condensée (LPMC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), IMRB - 'Biomechanics and Respiratory Apparatus' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Weill Cornell Medicine [Qatar], Maladies génétiques d'expression pédiatrique [CHU Trousseau] (Inserm U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), UF de Génétique moléculaire [CHU Trousseau], CHU Trousseau [APHP], Service d’ORL et de chirurgie cervico-faciale [CHU Le Kremlin-Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Paris-Sud - Paris 11 - Faculté de médecine (UP11 UFR Médecine), and Université Paris-Sud - Paris 11 (UP11)
- Subjects
Inflammation ,IL-6 ,Interleukin-6 ,Research ,lcsh:R ,Repair mechanisms ,lcsh:Medicine ,Wound healing ,Epithelial Cells ,Interleukin 6 ,IL-9 ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Epithelial cell ,Nasal Mucosa ,Nasal Polyps ,Chronic Disease ,[SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic ,Humans ,[PHYS.COND.CM-DS-NN]Physics [physics]/Condensed Matter [cond-mat]/Disordered Systems and Neural Networks [cond-mat.dis-nn] ,Mucociliary clearance ,[PHYS.COND.CM-SCM]Physics [physics]/Condensed Matter [cond-mat]/Soft Condensed Matter [cond-mat.soft] ,Chronic rhinosinusitis with nasal polyps (CRSwNP) ,ComputingMilieux_MISCELLANEOUS ,Cells, Cultured ,Rhinitis - Abstract
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by an alteration in airway epithelial cell functions including barrier function, wound repair mechanisms, mucociliary clearance. The mechanisms leading to epithelial cell dysfunction in nasal polyps (NPs) remain poorly understood. Our hypothesis was that among the inflammatory cytokines involved in NPs, IL-6 could alter epithelial repair mechanisms and mucociliary clearance. The aim of this study was to evaluate the in vitro effects of IL-6 on epithelial repair mechanisms in a wound repair model and on ciliary beating in primary cultures of Human Nasal Epithelial Cells (HNEC). Methods Primary cultures of HNEC taken from 38 patients during surgical procedures for CRSwNP were used in an in vitro model of wound healing. Effects of increasing concentrations of IL-6 (1 ng/mL, 10 ng/mL, and 100 ng/mL) and other ILs (IL-5, IL-9, IL-10) on wound closure kinetics were compared to cultures without IL-modulation. After wound closure, the differentiation process was characterized under basal conditions and after IL supplementation using cytokeratin-14, MUC5AC, and βIV tubulin as immunomarkers of basal, mucus, and ciliated cells, respectively. The ciliated edges of primary cultures were analyzed on IL-6 modulation by digital high-speed video-microscopy to measure: ciliary beating frequency (CBF), ciliary length, relative ciliary density, metachronal wavelength and the ciliary beating efficiency index. Results Our results showed that: (i) IL-6 accelerated airway wound repair in vitro, with a dose–response effect whereas no effect was observed after other ILs-stimulation. After 24 h, 79% of wounded wells with IL6-100 were fully repaired, vs 46% in the IL6-10 group, 28% in the IL6-1 group and 15% in the control group; (ii) specific migration analyses of closed wound at late repair stage (Day 12) showed IL-6 had the highest migration compared with other ILs (iii) The study of the IL-6 effect on ciliary function showed that CBF and metachronal wave increased but without significant modifications of ciliary density, length of cilia and efficiency index. Conclusion The up-regulated epithelial cell proliferation observed in polyps could be induced by IL-6 in the case of prior epithelial damage. IL-6 could be a major cytokine in NP physiopathology.
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- 2019
48. Computer-assisted Analysis Helps Detect Inner Dynein Arm Abnormalities
- Author
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Escudier, Estelle, Couprie, Michel, Duriez, Bénédicte, Roudot-Thoraval, Françoise, Millepied, Marie-Claude, Prulière-Escabasse, Virginie, Labatte, Laurent, and Coste, André
- Published
- 2002
- Full Text
- View/download PDF
49. Micosis rinosinusales
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Coste, André, Bretagne, Stéphane, and Jankowski, Roger
- Published
- 2003
- Full Text
- View/download PDF
50. Predictive Value of Pulmonary Function Parameters for Sleep Apnea Syndrome
- Author
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ZERAH-LANCNER, FRANÇOISE, LOFASO, FREDERIC, DʼORTHO, MARIE PIA, DELCLAUX, CHRISTOPHE, GOLDENBERG, FRANÇOISE, COSTE, ANDRÉ, HOUSSET, BRUNO, and HARF, ALAIN
- Published
- 2000
- Full Text
- View/download PDF
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