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2. Parotid Gland Tumors: Molecular Diagnostic Approaches.

Author

Vrinceanu, Daniela, Dumitru, Mihai, Bratiloveanu, Miruna, Marinescu, Andreea, Serboiu, Crenguta, Manole, Felicia, Palade, Dragos Octavian, Costache, Adrian, Costache, Mariana, and Patrascu, Oana

Subjects
PAROTID gland tumors, REVERSE transcriptase polymerase chain reaction, MOLECULAR biology, PAROTID glands, MOLECULAR diagnosis, MUCOEPIDERMOID carcinoma
Abstract

Parotid gland pathology represents a web of differential diagnoses. There are many complex cases that require extensive diagnostic tests for a complete and correct final pathology diagnosis. Currently the official classification of parotid gland tumors extends over more than 40 subtypes. We performed a query of the PubMed database regarding the use of molecular biology tests in performing a better characterization of the tumors in specific cases. By using fluorescence in situ hybridization (FISH), reverse transcription polymerase chain reaction (RT-PCR) or next-generation sequencing, the team managing complex cases can offer a personalized therapeutic solution. We review the molecular differential diagnosis according to published articles in the last 5 years for many types of parotid gland tumors ranging from benign to borderline malign tumors to malign aggressive tumors. Mucoepidermoid carcinoma is a distinct subtype of parotid malignancy that was the subject of a consistent number of articles. However, the molecular biology diagnosis techniques helped more in excluding the diagnosis of mucoepidermoid carcinoma, and probably retrospectively limiting the number of cases with this final diagnosis. In Romania, the molecular biology diagnosis is available only in limited research facilities and should receive more consistent funding that will make it available on a larger scale. The novelty of this scoping review is that we propose an algorithm for molecular differential diagnosis of the tumors that could be encountered in the parotid gland. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Interleukin-8, CXCL10, CXCL11 and their role in insulin resistance in adult females with subclinical hypothyroidism and prediabetes

Author

Stoica, Roxana Adriana, primary, Drăgana, Nicoleta, additional, Ancuceanu, Robert, additional, Geicu, Ovidiu Ionuț, additional, Guja, Cristian, additional, Pantea-Stoian, Anca, additional, Gheorghe, Damaris-Cristina, additional, Stefan-van Staden, Raluca-Ioana, additional, Serafinceanu, Cristian, additional, Costache, Adrian, additional, and Ionescu-Tîrgoviște, Constantin, additional

Published
2022
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10. Efficiency of platelet‑rich plasma therapy for healing sports injuries in young athletes

Author

Herdea, Alexandru, Struta, Alexandra, Derihaci, Răzvan Petru, Ulici, Alexandru, Costache, Adrian, Furtunescu, Florentina, Toma, Alexandra, and Charkaoui, Adham

Subjects
Cancer Research, meniscus, Immunology and Microbiology (miscellaneous), young, anterior cruciate ligament, platelet-rich plasma therapy, knee, Articles, General Medicine, sports
Abstract

In recent years, platelet-rich plasma (PRP) therapy has been a subject of controversy in orthopedics field. Our objective was to assess the efficiency of PRP therapy for patients who have suffered grade 2 meniscal lesions and grade 2 anterior cruciate ligament (ACL) lesions, graded by magnetic resonance imaging (MRI). A retrospective observational study was conducted, which included 72 young recreational athletes who had been diagnosed with grade 2 meniscal injury, graded using MRI, that benefited from PRP therapy as an enhancement of the primary treatment, after cast immobilization. The Lysholm score, the pain intensity and the resuming of the physical activity before the PRP treatment and one month after were analyzed. Our study revealed that patients had an improved subjective perception of pain after PRP therapy and an improvement of the Lysholm score. Concurrently, 83.3% of patients could return to sports and daily physical activity. It can be concluded that PRP therapy is a safe, easy to manage treatment, efficient for pain relief and in resuming of sports activities for young recreational athletes who have sustained partial meniscal or ACL tears. In terms of pain relief, it appears that the PRP therapy could be more efficient for young patients with ACL injuries.

Published
2022

16. Risk Factors for Extraintestinal Manifestations in Inflammatory Bowel Diseases - Data from the Romanian National Registry

Author

Singeap, Ana-Maria, primary, Girleanu, Irina, primary, Diculescu, Mircea, primary, Gheorghe, Liana, primary, Ciocîrlan, Maria, primary, Gheorghe, Cristian, primary, Costache, Adrian, primary, Tanțău, Alina, primary, Zaharie, Roxana, primary, Goldis, Adrian, primary, Gheonea, Dan, primary, Dobru, Daniela, primary, Dumitru, Eugen, primary, Prelipcean, Cristina Cijevschi, primary, Gîlcă-Blanariu, Georgiana-Emmanuela, primary, Moscalu, Mihaela, primary, Stanciu, Carol, primary, and Trifan, Anca, primary

Published
2021
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23. Sleep Disturbances and Their Impact on Socio-Professional Capacities in Patients with Obstructive Sleep Apnea

Author

NEAGOS, Adriana, primary, COSTACHE, Adrian, additional, GHEORGHE, Dan, additional, GEORGESCU, Madalina, additional, NECULA, Violeta, additional, MARTU, Cristian, additional, PADURARU, Luminita, additional, BUDACU, Cristian, additional, OLARIU, Raluca, additional, VRINCEANU, Daniela, additional, HINGANU, Delia, additional, and COZMA, Sebastian, additional

Published
2021
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24. Applications and challenges of neural networks in otolaryngology (Review).

Author

Taciuc, Iulian-Alexandru, Dumitru, Mihai, Vrinceanu, Daniela, Gherghe, Mirela, Manole, Felicia, Marinescu, Andreea, Serboiu, Crenguta, Neagos, Adriana, and Costache, Adrian

Subjects
ARTIFICIAL intelligence, ACCURACY of information
Abstract

Artificial Intelligence (AI) has become a topic of interest that is frequently debated in all research fields. The medical field is no exception, where several unanswered questions remain. When and how this field can benefit from AI support in daily routines are the most frequently asked questions. The present review aims to present the types of neural networks (NNs) available for development, discussing their advantages, disadvantages and how they can be applied practically. In addition, the present review summarizes how NNs (combined with various other features) have already been applied in studies in the ear nose throat research field, from assisting diagnosis to treatment management. Although the answer to this question regarding AI remains elusive, understanding the basics and types of applicable NNs can lead to future studies possibly using more than one type of NN. This approach may bypass the actual limitations in accuracy and relevance of information generated by AI. The proposed studies, the majority of which used convolutional NNs, obtained accuracies varying 70-98%, with a number of studies having the AI trained on a limited number of cases (<100 patients). The lack of standardization in AI protocols for research negatively affects data homogeneity and transparency of databases. [ABSTRACT FROM AUTHOR]

Published
2024
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32. For wind turbines in complex terrain, the devil is in the detail

Author

Lange, Julia, Mann, Jakob, Berg, Jacob, Parvu, Dan, Kilpatrick, Ryan, Costache, Adrian, Chowdhury, Jubayer, Siddiqui, Kamran, Hangan, Horia, Lange, Julia, Mann, Jakob, Berg, Jacob, Parvu, Dan, Kilpatrick, Ryan, Costache, Adrian, Chowdhury, Jubayer, Siddiqui, Kamran, and Hangan, Horia

Abstract

The cost of energy produced by onshore wind turbines is among the lowest available; however, onshore wind turbines are often positioned in a complex terrain, where the wind resources and wind conditions are quite uncertain due to the surrounding topography and/or vegetation. In this study, we use a scale model in a three-dimensional wind-testing chamber to show how minor changes in the terrain can result in significant differences in the flow at turbine height. These differences affect not only the power performance but also the life-time and maintenance costs of wind turbines, and hence, the economy and feasibility of wind turbine projects. We find that the mean wind, wind shear and turbulence level are extremely sensitive to the exact details of the terrain: a small modification of the edge of our scale model, results in a reduction of the estimated annual energy production by at least 50% and an increase in the turbulence level by a factor of five in the worst-case scenario with the most unfavorable wind direction. Wind farm developers should be aware that near escarpments destructive flows can occur and their extent is uncertain thus warranting on-site field measurements.

Published
2017

35. ANALYSIS OF THE DYNAMIC INTERACTION OF AN AGRICULTURAL MACHINE WITH THE ENVIRONMENT.

Author

Ovanisof, Alina, Popa, Constantin, Costache, Adrian, and Ion, George-Cătălin

Subjects
AGRICULTURAL equipment, TILLAGE, VISCOELASTICITY, FINITE element method, TECHNOLOGICAL innovations
Abstract

Using vibration processing techniques in tilling is convenient due to design simplicity of the involved devices, as well as to efficiency reasons, such as soil compaction reduction. However, depending on the design of the agricultural machine and on the working regime, such methods can affect the environment, the comfort of the human operator and even his health. The paper studies some effects of the vibrations of an agricultural machine with an eccentric rotating mass, transmitted to the soil and to the human operator. The machine is modeled as a rigid body with an eccentric rotating mass. The interaction of the device with the soil is intermediated by a viscoelastic system, i.e. by a system which can be assimilated with a spring and a damper. At the same time, the hand of the human operator is modeled as another viscoelastic system, consisting of two springs and two dampers. The vibrations are produced by the eccentric mass which rotates with constant angular velocity. The equations of motion of the system were obtained by numeric integration. The amplitudes of the parameters defining the configuration of the system, as well as the amplitudes of the forces transmitted to the soil and to the human operator, were determined by computing the maximum values taken by the corresponding parameters, after a time interval considered long enough for the system to attain the steady state. [ABSTRACT FROM AUTHOR]

Published
2018
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36. INFLUENCE OF TILT ANGLE OF SIEVES ON THE QUALITY OF SEPARATION OF SEEDS IN THE WINDROWS.

Author

POPA, Constantin, OVANISOF, Alina, COSTACHE, Adrian, and PETRE, Roxana - Alexandra

Subjects
WHEAT, WINDROW composting, SEED separators, SIEVES, CENTRIFUGAL pumps
Abstract

In this paper a theoretical and experimental study is performed, regarding the optimal seeds separation solution, by size and shape, in the air stream, given by a centrifugal fan, on the sieves of an experimental stand. The stand is also equipped with two blocks, each with two sieves whose slopes have been adjusted to four values. The determinations were made on winter wheat (Triticum Vulgare), winter barley (Hordeum Vulgare) and millet (Panicum Miliaceum), for several values of the inlet flow. Experiments were made with a centrifugal fan. Seeds quality index values generally increase with the inclination angles of the tiller sieves and are smaller for wheat than for barley seeds. Determinations have been made for: the high impurities separation index of the initial seed mass as a function of the slope of the lower site of the upper block with the sieves as well as the low seed index of the initial seed mass as a function of the inclination of the bottom site top block. All these determinations were made after determining the working capacity of the windrow and depending on the quantity of wheat or barley conditioned, the time required for each experimental determination, the small seed content of the mixture as well as the size of the sieves. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Influence of the Rotating Piston Shape on the Flow Rate of a New Type of Rotating Working Machine.

Author

ALMASLAMANI, Ammar Fadhil Shnawa, COSTACHE, Adrian, and BĂRAN, Nicolae

Subjects
PISTONS, ROTORS, FLUID flow, ROTATING machinery, HYDRAULICS
Abstract

The paper presents a new constructive solution for a rotating pump that contains two profiled rotors; each rotor has two pistons that may be triangular or curvilinear (oval). The area difference of the two pistons in a cross section is calculated; there is a difference in area which at each piston rotation, will reduce the flow rate circulated by the curved pistons. [ABSTRACT FROM AUTHOR]

Published
2018

43. Of questions. For didactic use

Author

Costache, Adrian and Departement für deutschsprachige Lehrerausbildung an der Babes-Bolyai Universität Klausenburg

Subjects
Lehrer-Schüler-Kommunikation, Geisteswissenschaftlicher Unterricht, Erziehung, Schul- und Bildungswesen, Romania, Conversational teaching, Dialog, Unterrichtsgespräch, Questioning, Didaktik, Method of teaching, 370 Erziehung, Schul- und Bildungswesen, Rumänien, Education, Fragetechnik, Fachdidaktik/fächerübergreifende Bildungsthemen, ddc:370, Gesprächsführung, Frage, Fragend-entwickelnder Unterricht, Humanities instruction, Training method, Unterrichtsmethode, Dialogue, 370 Education
Abstract

Neue Didaktik (2010) 2, S. 100-109, The present paper is aimed at the teachers (to be) of human sciences (especially economics) and offers an in-depth commentary and interpretation of Hans-Georg Gadamer’s view of the concept of question and the activity of questioning. The goal of the paper is to circumscribe the conditions of interrogation thus offering the teachers (to be) a means of enhancing the didactic efficiency of the learning sequences based on questioning. (DIPF/Orig.), Die vorliegende Arbeit ist für die zukünftigen Lehrer für Geisteswissenschaften gedacht. Sie bietet einen ausführlichen Kommentar und eine Interpretation der Doktrin des deutschen Philosophen Hans-Georg Gadamer über Frage und Interrogation. Das Ziel der Arbeit ist, die Bedingungen jeder Interrogation einzugrenzen, und somit die Mittel der didaktischen Effizienz der Unterrichtssequenzen, die auf Fragen basieren sind, zu erweitern. (DIPF/Orig.)

Published
2010
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