Search

Your search keyword '"Costa NCM"' showing total 32 results
Start Over Author "Costa NCM"
32 results on '"Costa NCM"'

13. SANGRAMENTO E CONSUMO DE PRÓ-COAGULANTES NO PRIMEIRO ANO DE PROFILAXIA COM EMICIZUMABE EM PESSOAS COM HEMOFILIA A E INIBIDOR

Author

Camelo, RM, Henriques, LCM, Santos, BRAD, Assunção, MCS, da EO, Silveira, Carvalho, LEM, Rebouças, TO, Swain, MB, Ferreira, MLA, Gonçalves, AV, Pinto, ISS, Figueiredo, SS, Casaretto, ES, Vanderlei, AM, Costa, IM, Costa, NCM, Guimarães, TMR, Santana, MP, Ferreira, CB, Luz, AC, Campoy, F, Filho Ferreira, JSS, Garcia, AA, Cabrera, B, Giacometto, PC, and Alvares-Teodoro, J

Published
2024
Full Text
View/download PDF

31. Cardiovascular Risk Scores among Asymptomatic Adults with Haemophilia.

Author

Camelo RM, Caram-Deelder C, Duarte BP, Moura MCB, Costa NCM, Costa IM, Vanderlei AM, Guimarães TMR, Gouw S, Rezende SM, and Bom JV

Subjects
Adult, Male, Humans, Middle Aged, Cross-Sectional Studies, Risk Factors, Heart Disease Risk Factors, Hemophilia A complications, Hemophilia A epidemiology, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology
Abstract

Background: The mortality rate of Brazilian people with haemophilia (PwH) is decreasing, but the relative incidence of deaths associated with cardiovascular disease (CVD) is increasing., Objectives: We aimed to describe the CVD risk score of PwH according to Pooled Cohort Equations Risk (PCER) Calculator tool and its treatment recommendations. We also compared the PCER estimates with the respective Framingham Risk Score (FRS)., Methods: This cross-sectional study included male PwH ≥ 40 years treated at the Comprehensive Haemophilia Treatment Centre of Pernambuco (Recife/Brazil). PwH with a previous CVD event or a low-density lipid cholesterol ≥ 5.0 mmol/L were excluded. Interviews, medical file reviews, and blood tests were performed. The PCER tool was used to estimate the CVD risk and compare it with the respective FRS. A p-value < 0.05 was accepted as statistically significant., Results: Thirty PwH were included. Median age was 51.5 [interquartile range-IQR; 46.0-59.5] years. The prevalence of obesity, systemic arterial hypertension, diabetes mellitus, hypertriglyceridaemia, hypercholesterolaemia, and hypoHDLaemia were 20%, 67%, 24%, 14%, 47%, and 23%, respectively. The median PCER score was 6.9% [IQR; 3.1-13.2], with 50% having a high risk (PCER ≥ 7.5%). Statin use was suggested for 54% of PwH. Blood pressure was poorly controlled in 47% of PwH. The agreement between PCER and FRS was 80% (κ = 0.60; p = 0.001)., Conclusions: Half of the male people with haemophilia aged 40 years or older had a 10-year high risk of developing CVD with strong recommendations to improve control of dyslipidaemia and blood pressure.

Published
2023
Full Text
View/download PDF

32. Cardiovascular risk factors among adult patients with haemophilia.

Author

Camelo RM, Caram-Deelder C, Duarte BP, de Moura MCB, Costa NCM, Costa IM, Roncal CGP, Vanderlei AM, Guimaraes TMR, Gouw S, Rezende SM, and van der Bom J

Subjects
Adult, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Cardiovascular Diseases blood, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, Cardiovascular Diseases physiopathology, Hemophilia A blood, Hemophilia A complications, Hemophilia A epidemiology, Hemophilia A physiopathology
Abstract

Since the introduction of episodic and prophylactic treatments with safer factor concentrates, the life expectancy of people with haemophilia (PwH) has improved considerably. Ageing-related diseases such as cardiovascular disease (CVD) have also become more prevalent in PwH. This cross-sectional study aimed to evaluate CVD risk factors and estimate 10-year risk for CVD events among PwH. Male patients ≥ 30 years were interviewed and examined. Blood tests were performed at the local laboratory. Eighty-two patients were included, of whom 83% had haemophilia A and half had severe disease. Median age at study entry was 43.0 years (interquartile range [IQR], 36.0-51.3). Prevalence of obesity, systemic arterial hypertension (SAH) and diabetes mellitus were 16%, 60% and 16%, respectively. Hypertriglyceridaemia, hypercholesterolaemia and low HDL blood levels were present in 18%, 41% and 30% of patients, respectively. Metabolic syndrome was found in 37%. The Framingham Risk Score showed that 39% of PwH had a high risk of developing cardiovascular events in the following 10 years. We conclude that, in this cohort, PwH have a higher prevalence of SAH when compared with Brazilian men without haemophilia and about two-fifths have a high risk of developing a CVD event in the following 10 years.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results