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161 results on '"Costa, Tania Maria Haas"'

7. Magnetic Mesoporous Silica for Targeted Drug Delivery of Chloroquine: Synthesis, Characterization, and In Vitro Evaluation

Author

de Andrade, Rafaela, primary, Schmidt, Rita de Cássia dos Reis, additional, Gomes, Leonardo Santos, additional, Colina-Vegas, Legna, additional, Hinrichs, Ruth, additional, Vasconcellos, Marcos Antônio Zen, additional, Costa, Tania Maria Haas, additional, Deon, Monique, additional, Villarreal, Wilmer, additional, and Benvenutti, Edilson Valmir, additional

Published
2024
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25. Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process

Author

de Oliveira, Rafaela Santos, primary, Funk, Nadine Lysyk, additional, dos Santos, Juliana, additional, de Oliveira, Thayse Viana, additional, de Oliveira, Edilene Gadelha, additional, Petzhold, Cesar Liberato, additional, Costa, Tania Maria Haas, additional, Benvenutti, Edilson Valmir, additional, Deon, Monique, additional, and Beck, Ruy Carlos Ruver, additional

Published
2022
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36. Bioadhesive 3D-Printed Skin Drug Delivery Polymeric Films: From the Drug Loading in Mesoporous Silica to the Manufacturing Process.

Author

de Oliveira, Rafaela Santos, Funk, Nadine Lysyk, dos Santos, Juliana, de Oliveira, Thayse Viana, de Oliveira, Edilene Gadelha, Petzhold, Cesar Liberato, Costa, Tania Maria Haas, Benvenutti, Edilson Valmir, Deon, Monique, and Beck, Ruy Carlos Ruver

Subjects
MESOPOROUS silica, POLYMERIC drugs, MANUFACTURING processes, CLOBETASOL, PECTINS, CARBOXYMETHYLCELLULOSE
Abstract

The alliance between 3D printing and nanomaterials brings versatile properties to pharmaceuticals, but few studies have explored this approach in the development of skin delivery formulations. In this study, clobetasol propionate (CP) was loaded (about 25% w/w) in mesoporous silica nanomaterial (MSN) to formulate novel bioadhesive and hydrophilic skin delivery films composed of pectin (5% w/v) and carboxymethylcellulose (5% w/v) by 3D printing. As a hydrophobic model drug, CP was encapsulated in MSN at a 3:1 (w/w) ratio, resulting in a decrease of CP crystallinity and an increase of its dissolution efficiency after 72 h (65.70 ± 6.52%) as compared to CP dispersion (40.79 ± 4.75%), explained by its partial change to an amorphous form. The CP-loaded MSN was incorporated in an innovative hydrophilic 3D-printable ink composed of carboxymethylcellulose and pectin (1:1, w/w), which showed high tensile strength (3.613 ± 0.38 N, a homogenous drug dose (0.48 ± 0.032 mg/g per film) and complete CP release after 10 h. Moreover, the presence of pectin in the ink increased the skin adhesion of the films (work of adhesion of 782 ± 105 mN·mm). Therefore, the alliance between MSN and the novel printable ink composed of carboxymethylcellulose and pectin represents a new platform for the production of 3D-printed bioadhesive films, opening a new era in the development of skin delivery systems. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Double layer SiO2–TiO2 sol–gel thin films on glass for antireflection, antifogging, and UV recoverable self-cleaning

Author

Fardo, Frederico Meyer, Ribeiro, Rita S. Rodrigues, Strauss, Jamuarê de Almeida, Nardi, Julio Alberto, Ferreira, Licínio F., Schmökel, Gabriel, Costa, Tania Maria Haas, Pereira, Marcelo Barbalho, and Horowitz, Flavio

Subjects
Sol-gel, Filmes finos, Antirreflexo
Abstract

Double layer thin films, mechanically stable and adhering to glass, were produced through the sol–gel process, using tetraethyl orthosilicate and titanium butoxide as precursors. The refractive index of the titania and silica– titania composite layers were typically 2.1 and 1.7, and their physical thicknesses were approximately 65 nm and 81 nm, respectively, as determined by ellipsometry. These optical constants allowed attainment of quarterwave optical thicknesses at the center of the visible spectrum (550 nm) as designed, with an increase of 3.4% in transmittance. The nanometric surface roughness, measured by optical profilometry, was effective to decrease light scattering and water contact angles to below 10◦ . As novelty in dip-coated sol–gel films, superhydrophilicity for self-cleaning, antifogging, and antireflection in the mid-visible spectrum were simultaneously attained with durability of 9 weeks in the dark. Further application of UV light allowed regeneration of contact angles for self-cleaning.

Published
2020

43. Tuning anatase-rutile phase transition temperature : TiO2/SiO2 nanoparticles applied in dye-sensitized solar cells

Author

Cardoso, Billy Nunes, Kohlrausch, Emerson Cristofer, Laranjo, Marina Teixeira, Benvenutti, Edilson Valmir, Balzaretti, Naira Maria, Arenas, Leliz Ticona, Santos, Marcos José Leite, and Costa, Tania Maria Haas

Subjects
Difração de raios X, Tratamento térmico, Dióxido de silício, Dióxido de titânio, Células solares, Espectroscopia Raman
Abstract

TiO2/SiO2 nanoparticles with 3, 5, and 10 molar percent of silica, were synthesized by hydrothermal method and characterized by SEM, TEM, N2 adsorption-desorption isotherms, X-ray diffraction, and Raman and UV-Vis spectroscopy. While pristine TiO2 thermally treated at 500°C presents a surface area of 36 m2g-1(±10 m2g-1), TiO2/SiO2 containing 3, 5, and 10 molar percent of silica present surface areas of 93, 124, and 150 m2g-1(±10 m2g-1), respectively. SiO2is found to form very small amorphous domains well dispersed in the TiO2 matrix. X-ray diffraction and Raman spectroscopy data show that anatase-to-rutile phase transition temperature is delayed by the presence of SiO2, enabling single-anatase phase photoanodes for DSSCs. According to the I×V measurements, photoanodes with 3% of SiO2 result in improved efficiency, which is mainly related to increasedsurface area and dye loading. In addition, the results suggest a gain in photocurrent related to the passivation of defects by SiO2

Published
2019

50. High-grade MWCNT/ZrO2 composites prepared by sol–gel method and high-pressure technique (4.0 GPa): mechanically resistant, porous, and conductive.

Author

Mantey dos Santos, Pâmela Andréa, de Oliveira Almeida, Voltaire, Benvenutti, Edilson Valmir, Balzaretti, Naira Maria, Gallas, Márcia Russman, and Costa, Tania Maria Haas

Abstract

Preparation of bulk samples with high content of carbon nanotubes and still maintaining their impressive properties is not usual because the connection between them is very difficult. Several attempts to obtain carbon nanotube bulk samples have been made; however, the samples presented insufficient mechanical properties being brittle and difficult to handle. In the present work, multiwalled carbon nanotube/zirconia (MWCNT/ZrO2) composite compacted samples, containing nearly 40% of multiwalled carbon nanotubes or functionalized carbon nanotubes (MWCNT or f-MWCNT) dispersed in a zirconia matrix (ZrO2), were prepared for the first time. The sol–gel method was applied to warrant the connection between the MWCNT, associated with the high-pressure technique to impart mechanical properties. The samples that present the best characteristics in compaction and handling were the ones made with composite powders heat-treated at 300 °C. Subsequently, these powders were processed under high pressure (4 GPa) and high pressure/temperature (4 GPa/400 °C). These samples maintain significant content of MWCNT even after heat treatments. The physical and morphological integrity of the MWCNT were retained and yielded samples with impressive properties, such as high surface area (near 150 m2 g−1), load resistance (load/mass ratio >8000) and electrical conductivity (3 × 101 S m−1). Picture of high- grade MWCNT/ZrO2 composites prepared using sol–gel method and high- pressure technique. The best- compacted samples are presented, showing also the pore size distribution curves and the main characteristics of the samples, that are, conductivity and load resistance. Highlights: High-grade MWCNT/ZrO2 composites were obtained by sol–gel method and high-pressure technique. The integrity of the MWCNT was preserved so as to provide electrical conductivity (3 × 101 S m−1). CNT composite samples with impressive properties such as high surface area (close to 150 m2 g−1). Connection between MWCNT and ZrO2 matrix provides resistant samples with load/mass ratio >8000. [ABSTRACT FROM AUTHOR]

Published
2019
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