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2. Immunologic mediators profile in COVID-19 convalescence

Author

Silva-Junior, Alexander Leonardo, Oliveira, Lucas Silva, Dias, Stephanny, Costa, Thaina Cristina Cardoso, Xabregas, Lilyane Amorim, Alves-Hanna, Fabíola Silva, Abrahim, Cláudia Maria Moura, Neves, Walter Luiz Lima, Crispim, Myuki Alfaia Esashika, Toro, Diana Mota, Silva-Neto, Pedro Vieira, Aponte, Danielle Costa Marques, Oliveira, Tatiana Campos, Silva, Maria Carmo Costa, Matos, Miharu Maguinoria Matsuura, Carvalho, Maria Perpétuo Socorro Sampaio, Tarragô, Andrea Monteiro, Fraiji, Nelson Abrahim, Faccioli, Lúcia Helena, Sorgi, Carlos Artério, Sabino, Ester Cerdeira, Teixeira-Carvalho, Andrea, Martins-Filho, Olindo Assis, Costa, Allyson Guimarães, and Malheiro, Adriana

Published
2024
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3. Anodal transcranial direct current stimulation associated with aerobic exercise on the functional and physical capacity of patients with heart failure with reduced ejection fraction: ELETRIC study protocol

Author

da Silva, Vanessa Christina Costa, da Silva Arêas, Fernando Zanela, Lopes, Antônio Luiz Ribeiro Boechat, de Almeida e Val, Fernando Fonseca, da Costa, Allyson Guimarães, dos Santos, Joana Colares Correa, Ferreira, João Marcos Bemfica Barbosa, and Peixoto Tinoco Arêas, Guilherme

Published
2023
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6. Exploring cell-derived extracellular vesicles in peripheral blood and bone marrow of B-cell acute lymphoblastic leukemia pediatric patients: proof-of-concept study.

Author

Magalhães-Gama, Fábio, Silvestrini, Marina Malheiros Araújo, Ferreira Neves, Juliana Costa, Araújo, Nilberto Dias, Alves-Hanna, Fabíola Silva, Kerr, Marlon Wendell Athaydes, Carvalho, Maria Perpétuo Socorro Sampaio, Tarragô, Andréa Monteiro, Pontes, Gemilson Soares, Martins-Filho, Olindo Assis, Malheiro, Adriana, Teixeira-Carvalho, Andreá, and Costa, Allyson Guimarães

Subjects
CHILD patients, EXTRACELLULAR vesicles, LYMPHOBLASTIC leukemia, BONE marrow, T cells
Abstract

Extracellular vesicles (EVs) are heterogeneous, phospholipid membrane enclosed particles that are secreted by healthy and cancerous cells. EVs are present in diverse biological fluids and have been associated with the severity of diseases, which indicates their potential as biomarkers for diagnosis, prognosis and as therapeutic targets. This study investigated the phenotypic characteristics of EVs derived from peripheral blood (PB) and bone marrow (BM) in pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) during different treatment stages. PB and BM plasma were collected from 20 B-ALL patients at three time points during induction therapy, referred to as: diagnosis baseline (D0), day 15 of induction therapy (D15) and the end of the induction therapy (D35). In addition, PB samples were collected from 10 healthy children at a single time point. The EVs were measured using CytoFLEX S flow cytometer. Calibration beads were employed to ensure accurate size analysis. The following, fluorescent-labeled specific cellular markers were used to label the EVs: Annexin V (phosphatidylserine), CD235a (erythrocyte), CD41a (platelet), CD51 (endothelial cell), CD45 (leukocyte), CD66b (neutrophil), CD14 (monocyte), CD3 (T lymphocyte), CD19, CD34 and CD10 (B lymphoblast/leukemic blast). Our results demonstrate that B-ALL patients had a marked production of EV-CD51/61+, EV-CD10+, EV-CD19+ and EV-CD10+CD19+ (double-positive) with a decrease in EV-CD41a+ on D0. However, the kinetics and signature of production during induction therapy revealed a clear decline in EV-CD10+ and EV-CD19+, with an increase of EV-CD41a+ on D35. Furthermore, B-ALL patients showed a complex biological network, exhibiting distinct profiles on D0 and D35. Interestingly, fold change and ROC curve analysis demonstrated that EV-CD10+ CD19+ were associated with B-ALL patients, exhibited excellent clinical performance and standing out as a potential diagnostic biomarker. In conclusion, our data indicate that EVs represent a promising field of investigation in B-ALL, offering the possibility of identifying potential biomarkers and therapeutic targets. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Mediators profile in COVID-19 convalescence: an approach in individuals from amazon

Author

Silva-Junior, Alexander Leonardo, primary, Oliveira, Lucas Silva, additional, Dias, Stephanny, additional, Costa, Thaina Cristina Cardoso, additional, Xabregas, Lilyane Amorim, additional, Alves-Hanna, Fabiola Silva, additional, Abrahim, Cláudia Maria Moura, additional, Neves, Walter Luiz Lima, additional, Crispim, Myuki Alfaia Esashika, additional, Toro, Diana Mota, additional, Silva-Neto, Pedro Vieira, additional, Aponte, Danielle Costa Marques, additional, Oliveira, Tatiana Campos, additional, Silva, Maria Carmo Costa, additional, Matos, Miharu Maguinoria Matsuura, additional, Carvalho, Maria Socorro Sampaio, additional, Tarrago, Andrea Monteiro, additional, Fraiji, Nelson Abrahim, additional, Faccioli, Lúcia Helena, additional, Sorgi, Carlos Artério, additional, Sabino, Ester Cerdeira, additional, Teixeira-Carvalho, Andrea, additional, Martins-Filho, Olindo Assis, additional, Costa, Allyson Guimarães, additional, and Malheiro, Adriana, additional

Published
2024
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8. Urinary proteomics reveals biological processes related to acute kidney injury in Bothrops atrox envenomings

Author

Brasileiro-Martins, Lisele Maria, primary, Cavalcante, Sofia Angiole, additional, Nascimento, Thaís Pinto, additional, Silva-Neto, Alexandre Vilhena, additional, Mariano Santos, Marlon Dias, additional, Camillo-Andrade, Amanda C., additional, da Gama Fischer, Juliana de Saldanha, additional, Ferreira, Caroline Coelho, additional, Oliveira, Lucas Barbosa, additional, Sartim, Marco Aurelio, additional, Costa, Allyson Guimarães, additional, Pucca, Manuela B., additional, Wen, Fan Hui, additional, Moura-da-Silva, Ana Maria, additional, Sachett, Jacqueline, additional, Carvalho, Paulo Costa, additional, de Aquino, Priscila Ferreira, additional, and Monteiro, Wuelton M., additional

Published
2024
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9. Performance of immunological assays for universal and differential diagnosis of HTLV-1/2 infection in candidates for blood donations from the Brazilian Amazon.

Author

Santos, Felipe Araujo, Catão, Cláudio Lucas Santos, Martins, Júlia Pereira, Pessoa, Uzamôr Henrique Soares, Sousa, Isabelle Vasconcelos, Melo, Jean Silva, Souza, Gláucia Lima, Araújo, Nilberto Dias, Magalhães-Gama, Fábio, Abrahim, Cláudia Maria de Moura, Mourão, Emmily Myrella Vasconcelos, Peruhype-Magalhães, Vanessa, Coelho-dos-Reis, Jordana Grazziela Alves, Teixeira-Carvalho, Andréa, Vallinoto, Antonio Carlos Rosário, Pontes, Gemilson Soares, Araújo, Márcio Sobreira Silva, Martins-Filho, Olindo Assis, and Costa, Allyson Guimarães

Subjects
DIFFERENTIAL diagnosis, HTLV, INFECTION
Abstract

The present study compares the ability of distinct immunological assays (chemiluminescence immunoassay-CLIA, western blot-WB and flow cytometry-FC-Simplex and Duplex) to detect anti-HTLV (human T-lymphotropic virus) antibodies in candidates for blood donations at the Amazonas State Blood Center (Brazil) between January 2018 and December 2022. Overall, 257,942 samples from candidates for blood donations were screened using CLIA, which led to 0.15% seropositivity for HTLV (409 samples). A total of 151 candidates for blood donations were enrolled for retesting with CLIA followed by additional testing using WB and FC-Simplex and Duplex analysis. Our results demonstrated that 62% (93/151), 20% (30/151) and 17% (26/151) of the samples presented positive results with retesting using CLIA, WB and FC-Simplex analysis, respectively. Additional analysis of the CLIA, WB and FC-Simplex results revealed an overall agreement of 56% for CLIA and WB (22 co-negative; 30 co-positive samples), 48% for CLIA and FC-Simplex (21 co-negative; 24 co-positive samples) and 80% for WB and FC-Simplex (51 co-negative; 23 co-positive samples). Considering the WB as the reference standard for the diagnosis of infection with HTLV-1/2, we observed that the CLIA results of ≤3.0 RLU and >10.0 RLU in the retest can be used define a negative or positive result, respectively, and could be used as new specific cut-off values. The overall agreement between WB and FC-Duplex for accomplishing the differential diagnosis was evaluated and demonstrated 100% correspondence for the diagnosis of HTLV-1 (15/15) and HTLV-2 (7/7). Our findings demonstrate that gaps in the diagnosis of infection with HTLV-1/2 could be overcome by the simultaneous use of distinct immunological assays during retesting of candidates for blood donations. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Performance of Immunological Assays for Universal and Differential Diagnosis of HTLV-1/2 Infection in Candidates for Blood Donations from the Brazilian Amazon

Author

Santos, Felipe Araujo, primary, Catão, Cláudio Lucas Santos, additional, Martins, Júlia Pereira, additional, Pessoa, Uzamôr Henrique Soares, additional, Sousa, Isabelle Vasconcelos, additional, Melo, Jean Silva, additional, Souza, Gláucia Lima, additional, Araújo, Nilberto Dias, additional, Magalhães-Gama, Fábio, additional, Abrahim, Cláudia Maria de Moura, additional, Mourão, Emmily Myrella Vasconcelos, additional, Peruhype-Magalhães, Vanessa, additional, Coelho-dos-Reis, Jordana Grazziela Alves, additional, Teixeira-Carvalho, Andréa, additional, Vallinoto, Antonio Carlos Rosário, additional, Pontes, Gemilson Soares, additional, Araújo, Márcio Sobreira Silva, additional, Martins-Filho, Olindo Assis, additional, and da Costa, Allyson Guimarães, additional

Published
2024
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11. Detection of the JAK2V617F in Phildelphia-negative Myeloproliferative Neoplasms patients: Comparison of the PCR-RFLP and Nucleotide sequencing

Author

Laranjeira, Wanessa Horreda, primary, Torres, Dania Isamary Gutierrez, additional, Garcia, Nadja, additional, Costa, Allyson Guimarães da, additional, Malheiro, Adriana, additional, Mourão, Lucivana P. de Souza, additional, Silva, George Allan Villarouco da, additional, and Tarragô, Andréa Monteiro, additional

Published
2023
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12. Genetic polymorphisms of inflammasome genes associated with pediatric acute lymphoblastic leukemia and clinical prognosis in the Brazilian Amazon

Author

Alves, Fabíola Silva, Xabregas, Lilyane Amorim, Kerr, Marlon Wendell Athaydes, Souza, Gláucia Lima, Pereira, Daniele Sá, Magalhães-Gama, Fábio, Santiago, Mirian Rodrigues Ribeiro, Garcia, Nadja Pinto, Tarragô, Andréa Monteiro, Ogusku, Maurício Morishi, Sadahiro, Aya, Malheiro, Adriana, and Costa, Allyson Guimarães

Published
2021
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14. Immunologic biomarkers, morbidity and mortality among HIV patients hospitalised in a Tertiary Care Hospital in the Brazilian Amazon

Author

Gama, Wellington Mota, Frank, Carlos Henrique Michiles, Almeida, Taynná Vernalha Rocha, dos Santos, Daniel Silva, Chaves, Yury Oliveira, da Silva, Danielle Furtado, Orlandi, Patrícia Puccinelli, Pereira, Flávio Ribeiro, Magalhães, Gleicienne Feliz, Baptista, Bárbara Jóse, de Oliveira Silva, Viviane Lago, da Silva Balieiro, Antônio Alcirley, Santana, Monique Freire, Gonçalves, Roberta Lins, da Costa, Allyson Guimarães, dos Santos, Marcelo Cordeiro, de Lima Ferreira, Luís Carlos, Lacerda, Marcus Vinicius Guimaraes, and Nogueira, Paulo Afonso

Published
2021
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15. Statement of Peer Review—Immersing in a Neglected Problem Inside the Amazon Jungle: Abstracts of the 1st International Symposium on Research in Venomous Animals, Manaus, Brazil

Author

Sachett, Jacqueline, primary, Murta, Felipe, additional, da Silva, Ana Maria Moura, additional, de Farias, Altair Seabra, additional, Kaefer, Igor Luis, additional, Bisneto, Pedro, additional, Cerni, Felipe Augusto, additional, Carvalho, Érica da Silva, additional, Rocha, Gisele Santos, additional, Koolen, Hector, additional, Machado, Vinícius Azevedo, additional, Costa, Allyson Guimarães, additional, Sampaio, Vanderson, additional, Pucca, Manuela, additional, Wen, Fan Hui, additional, Sartim, Marco Aurélio, additional, and Monteiro, Wuelton, additional

Published
2023
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16. Inflammatory Profile Associated with Secondary Infection from Bothrops atrox Snakebites in the Brazilian Amazon

Author

Cavalcante, Távila Tatiane Amorim, primary, de Souza, Márcia Beatriz Silva, additional, Neves, Juliana Costa Ferreira, additional, Ibiapina, Hiochelson Najibe Santos, additional, Barbosa, Fabiane Bianca Albuquerque, additional, Bentes, Karolaine Oliveira, additional, Alves, Eliane Campos, additional, Marques, Hedylamar Oliveira, additional, Colombini, Monica, additional, Sampaio, Suely Vilela, additional, Pucca, Manuela Berto, additional, Silva, Iran Mendonça da, additional, Ferreira, Luiz Carlos de Lima, additional, Sampaio, Vanderson de Souza, additional, Moura-da-Silva, Ana Maria, additional, Costa, Allyson Guimarães, additional, Monteiro, Wuelton Marcelo, additional, Sachett, Jacqueline Almeida Gonçalves, additional, and Sartim, Marco Aurélio, additional

Published
2023
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17. Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone

Author

Mwangi, Victor Irungu, primary, Netto, Rebeca Linhares Abreu, additional, de Morais, Carlos Eduardo Padron, additional, Silva, Arineia Soares, additional, Silva, Bernardo Maia, additional, Lima, Amanda Barros, additional, Neves, Juliana Costa Ferreira, additional, Borba, Mayla Gabriela Silva, additional, Val, Fernando Fonseca de Almeida e, additional, de Almeida, Anne Cristine Gomes, additional, Costa, Allyson Guimarães, additional, Sampaio, Vanderson de Souza, additional, Gardinassi, Luiz Gustavo, additional, de Lacerda, Marcus Vinicius Guimarães, additional, Monteiro, Wuelton Marcelo, additional, and de Melo, Gisely Cardoso, additional

Published
2023
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18. Immersing in a Neglected Problem Inside the Amazon Jungle: Abstracts of the 1st International Symposium on Research in Venomous Animals, Manaus, Brazil

Author

Sachett, Jacqueline, primary, Murta, Felipe, additional, da Silva, Ana Maria Moura, additional, de Farias, Altair Seabra, additional, Kaefer, Igor Luis, additional, Bisneto, Pedro, additional, Cerni, Felipe, additional, Carvalho, Érica da Silva, additional, Rocha, Gisele Santos, additional, Koolen, Hector, additional, Machado, Vinícius Azevedo, additional, Costa, Allyson Guimarães, additional, Sampaio, Vanderson, additional, Pucca, Manuela, additional, Wen, Fan Hui, additional, Sartim, Marco Aurélio, additional, and Monteiro, Wuelton, additional

Published
2023
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19. Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?

Author

Alves-Hanna, Fabíola Silva, primary, Crespo-Neto, Juniel Assis, additional, Nogueira, Glenda Menezes, additional, Pereira, Daniele Sá, additional, Lima, Amanda Barros, additional, Ribeiro, Thaís Lohana Pereira, additional, Santos, Vitória Giovanna Rodrigues, additional, Fonseca, Joey Ramone Ferreira, additional, Magalhães-Gama, Fábio, additional, Sadahiro, Aya, additional, and Costa, Allyson Guimarães, additional

Published
2023
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21. Systemic immunological profile of children with B-cell acute lymphoblastic leukemia: performance of cell populations and soluble mediators as serum biomarkers.

Author

Socorro Sampaio Carvalho, Maria Perpétuo, Magalhães-Gama, Fábio, Loiola, Bruna Pires, Ferreira Neves, Juliana Costa, Araújo, Nilberto Dias, Silva, Flavio Souza, Santos Catão, Claudio Lucas, Alves, Eliana Brasil, Diniz Pimentel, João Paulo, Saunier Barbosa, Maria Nazaré, Fraiji, Nelson Abrahim, Teixeira-Carvalho, Andréa, Martins-Filho, Olindo Assis, Costa, Allyson Guimarães, and Malheiro, Adriana

Subjects
CELL populations, LYMPHOBLASTIC leukemia, ACUTE leukemia, REGULATORY T cells, T cells
Abstract

Background: Children with B-cell acute lymphoblastic leukemia (B-ALL) have an immune imbalance that is marked by remodeling of the hematopoietic compartment, with effects on peripheral blood (PB). Although the bone marrow (BM) is the main maintenance site of malignancy, the frequency with which immune cells and molecules can be monitored is limited, thus the identification of biomarkers in PB becomes an alternative for monitoring the evolution of the disease. Methods: Here, we characterize the systemic immunological profile in children undergoing treatment for B-ALL, and evaluate the performance of cell populations, chemokines and cytokines as potential biomarkers during clinical follow-up. For this purpose, PB samples from 20 patients with B-ALL were collected on diagnosis (D0) and during induction therapy (days 8, 15 and 35). In addition, samples from 28 children were used as a control group (CG). The cellular profile (NK and NKT-cells, Treg, CD3+ T, CD4+ T and CD8+ T cells) and soluble immunological mediators (CXCL8, CCL2, CXCL9, CCL5, CXCL10, IL-6, TNF, IFN-γ, IL-17A, IL- 4, IL-10 and IL-2) were evaluated via flow cytometry immunophenotyping and cytometric bead array assay. Results: On D0, B-ALL patients showed reduction in the frequency of cell populations, except for CD4+ T and CD8+ T cells, which together with CCL2, CXCL9, CXCL10, IL-6 and IL-10 were elevated in relation to the patients of the CG. On D8 and D15, the patients presented a transition in the immunological profile. While, on D35, they already presented an opposite profile to D0, with an increase in NKT, CD3+ T, CD4+ T and Treg cells, along with CCL5, and a decrease in the levels of CXCL9, CXCL10 and IL-10, thus demonstrating that B-ALL patients present a complex and dynamic immune network during induction therapy. Furthermore, we identified that many immunological mediators could be used to classify the therapeutic response based on currently used parameters. Conclusion: Finally, it is noted that the systemic immunological profile after remission induction still differs significantly when compared to the GC and that multiple immunological mediators performed well as serum biomarkers. [ABSTRACT FROM AUTHOR]

Published
2023
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23. Exploring the Profile of Cell Populations and Soluble Immunological Mediators in Bothrops atrox Envenomations

Author

Coelho, Kerolaine Fonseca, primary, Neves, Juliana Costa Ferreira, additional, Ibiapina, Hiochelson Najibe Santos, additional, Magalhães-Gama, Fábio, additional, Barbosa, Fabiane Bianca Albuquerque, additional, Silva, Flavio Souza, additional, Wellmann, Irmgardt Alicia María, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Tarragô, Andréa Monteiro, additional, Ferreira, Luiz Carlos Lima, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2023
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24. Immersing in a Neglected Problem Inside the Amazon Jungle: Abstracts of the 1st International Symposium on Research in Venomous Animals, Manaus, Brazil †.

Author

Sachett, Jacqueline, Murta, Felipe, da Silva, Ana Maria Moura, de Farias, Altair Seabra, Kaefer, Igor Luis, Bisneto, Pedro, Cerni, Felipe, Carvalho, Érica da Silva, Rocha, Gisele Santos, Koolen, Hector, Machado, Vinícius Azevedo, Costa, Allyson Guimarães, Sampaio, Vanderson, Pucca, Manuela, Wen, Fan Hui, Sartim, Marco Aurélio, and Monteiro, Wuelton

Subjects
LABORATORY animals, JUNGLES, VENOM, SCIENTIFIC method, MEDICAL economics, ECOSYSTEMS, HUMAN-animal relationships
Abstract

The Amazon represents the world's greatest biodiversity and covers different countries in South America, including Brazil with the largest area. The interaction between the resident population of this area and its ecosystem is responsible for an intense exposure to venomous animals, which are considered an important health issue in the region. Therefore, the 1st International Symposium on Research in Venomous Animals, held from 2 May to 5 May 2023 in the city of Manaus in the state of Amazonas in Brazil, aimed to address animal envenomation aspects in the Brazilian Amazon and the exchange of ideas and knowledge between research groups from around the world. The event was attended by graduate students as well as renowned researchers from the Americas, Europe, and Asia. The event presented a multidisciplinary and translational approach in the area of toxinology, including themes such as clinical envenomation (clinical management, pathophysiology, and public policy strategies), preclinical studies, biological aspects of venomous animals' venoms (venom composition/variation and geographical distribution), interdisciplinary studies on health anthropology and economics, and bioprospecting aspects (toxins with therapeutic and/or technological potential). [ABSTRACT FROM AUTHOR]

Published
2023
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25. The Yin-Yang of myeloid cells in the leukemic microenvironment: Immunological role and clinical implications

Author

Magalhães-Gama, Fábio, primary, Alves-Hanna, Fabíola Silva, additional, Araújo, Nilberto Dias, additional, Barros, Mateus Souza, additional, Silva, Flavio Souza, additional, Catão, Claudio Lucas Santos, additional, Moraes, Júlia Santos, additional, Freitas, Izabela Cabral, additional, Tarragô, Andréa Monteiro, additional, Malheiro, Adriana, additional, Teixeira-Carvalho, Andréa, additional, and Costa, Allyson Guimarães, additional

Published
2022
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26. CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite

Author

Neves, Juliana Costa Ferreira, primary, Ibiapina, Hiochelson Najibe Santos, additional, Magalhães-Gama, Fábio, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Silva, Iran Mendonça, additional, Coelho, Kerolaine Fonseca, additional, Alves, Eliane Campos, additional, Tarragô, Andréa Monteiro, additional, de Lima Ferreira, Luiz Carlos, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2022
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27. Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes

Author

Coutinho-da-Silva, Mikelly Santos, primary, Sucupira, Pedro Henrique Ferreira, additional, Bicalho, Kelly Alves, additional, Campi-Azevedo, Ana Carolina, additional, Brito-de-Sousa, Joaquim Pedro, additional, Peruhype-Magalhães, Vanessa, additional, Rios, Maria, additional, Teixeira-Carvalho, Andréa, additional, Coelho-dos-Reis, Jordana Grazziela Alves, additional, Antonelli, Lis Ribeiro do Valle, additional, Rezende, Vitor Bortolo de, additional, Melo, Fernanda Ludolf Ribeiro de, additional, Garcia, Cristiana Couto, additional, Silva-Andrade, Jesuanne Carla, additional, Costa-Rocha, Ismael Artur da, additional, Bastos, Michele de Souza, additional, Rocha, Lucia Alves da, additional, Silva, Valderjane Aprigio, additional, Ferreira, Ewerton da Silva, additional, Marinho, Eveny Perlize Melo, additional, Costa, Allyson Guimarães, additional, Gomes, Matheus de Souza, additional, Amaral, Laurence Rodrigues, additional, Furtado, Erilene Cristina da Silva, additional, Silva, Eliana Vieira Pinto da, additional, Ramos, Bruna Alves, additional, Santos, Éder Barros dos, additional, Freitas, Maria Nazaré Oliveira, additional, Vasconcelos, Pedro Fernando da Costa, additional, Martins-Filho, Olindo Assis, additional, Araújo, Márcio Sobreira Silva, additional, Ferreira, Milene Silveira, additional, and Martins, Livia Carício, additional

Published
2022
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28. Clinical Implication of SNVs in TLR Genes in Pediatric Patients From the Brazilian Amazon With Acute Lymphoblastic Leukemia

Author

Xabregas, Lilyane Amorim, primary, Hanna, Fabíola Silva Alves, additional, Magalhães-Gama, Fábio, additional, Souza, Gláucia Lima, additional, Pereira, Daniele Sá, additional, Lima, Amanda Barros, additional, Toro, Diana Mota, additional, Santiago, Mirian Rodrigues Ribeiro, additional, Passos, Leny Nascimento Motta, additional, Tarragô, Andréa Monteiro, additional, Malheiro, Adriana, additional, and Costa, Allyson Guimarães, additional

Published
2022
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29. Bone Marrow Soluble Immunological Mediators as Clinical Prognosis Biomarkers in B-Cell Acute Lymphoblastic Leukemia Patients Undergoing Induction Therapy

Author

Kerr, Marlon Wendell Athaydes, primary, Magalhães-Gama, Fábio, additional, Ibiapina, Hiochelson Najibe Santos, additional, Hanna, Fabíola Silva Alves, additional, Xabregas, Lilyane Amorim, additional, Alves, Eliana Brasil, additional, Pimentel, João Paulo Diniz, additional, Carvalho, Maria Perpétuo Socorro Sampaio, additional, Tarragô, Andréa Monteiro, additional, Teixeira-Carvalho, Andréa, additional, Martins-Filho, Olindo Assis, additional, da Costa, Allyson Guimarães, additional, and Malheiro, Adriana, additional

Published
2021
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31. γδ T Cells for Leukemia Immunotherapy: New and Expanding Trends

Author

Barros, Mateus de Souza, primary, de Araújo, Nilberto Dias, additional, Magalhães-Gama, Fábio, additional, Pereira Ribeiro, Thaís Lohana, additional, Alves Hanna, Fabíola Silva, additional, Tarragô, Andréa Monteiro, additional, Malheiro, Adriana, additional, and Costa, Allyson Guimarães, additional

Published
2021
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33. Imbalance of Chemokines and Cytokines in the Bone Marrow Microenvironment of Children with B-Cell Acute Lymphoblastic Leukemia

Author

Magalhães-Gama, Fábio, primary, Kerr, Marlon Wendell Athaydes, additional, de Araújo, Nilberto Dias, additional, Ibiapina, Hiochelson Najibe Santos, additional, Neves, Juliana Costa Ferreira, additional, Hanna, Fabíola Silva Alves, additional, Xabregas, Lilyane de Amorim, additional, Carvalho, Maria Perpétuo Socorro Sampaio, additional, Alves, Eliana Brasil, additional, Tarragô, Andréa Monteiro, additional, Martins-Filho, Olindo Assis, additional, Teixeira-Carvalho, Andréa, additional, Malheiro, Adriana, additional, and da Costa, Allyson Guimarães, additional

Published
2021
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34. Inflammasome genes polymorphisms may influence the development of hepatitis C in the Amazonas, Brazil

Author

Toro, Diana Mota, primary, Ramasawmy, Rajendranath, additional, Silva Neto, Pedro Vieira, additional, Pereira, Grenda Leite, additional, Sarmento, Priscila Santos, additional, Dray, Hanna Lara Silva Negreiros, additional, Sousa, Keyla Santos, additional, Affonso, Juliana Santos, additional, Silva, Jéssica Albuquerque, additional, Garcia, Nadja Pinto, additional, Barbieri, Marilú Victória, additional, Victória, Flamir Silva, additional, Donadi, Eduardo Antônio, additional, Costa, Allyson Guimarães, additional, Ogusku, Mauricio Morishi, additional, Sadahiro, Aya, additional, Tarragô, Andréa Monteiro, additional, and Malheiro, Adriana, additional

Published
2021
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36. Bee sting envenomation severe cases in Manaus, Brazilian Amazon: clinical characteristics and immune markers of case reports

Author

Mendonça-da-Silva, Iran, Monteiro, Wuelton Marcelo, Sachett, Jacqueline Almeida Gonçalves, Barbosa, Endila Souza, Cordeiro-dos-Santos, Marcelo, Lacerda, Marcus Vinícius Guimarães, Melo, Gisely Cardoso, Costa, Allyson Guimarães, and Val, Fernando Fonseca Almeida

Subjects
Africanized bees, Inflammatory response, Systemic injury
Abstract

Bee venom is a natural toxin composed of several peptides. Massive envenoming causes severe local and systemic reactions. We report two cases of severe bee envenomation, of which one was fatal. We also describe clinical characteristics and immune markers. Both victims suffered from respiratory distress, renal failure, rhabdomyolysis, and shock. They required invasive mechanical ventilation, vasoactive drugs, and renal replacement therapy. Moreover, serum levels of chemokines, cytokines, and cell-free circulating nucleic acids demonstrated an intense inflammatory process. Massive envenoming produced systemic injury in the victims, with an uncontrolled inflammatory response, and a more significant chemotactic response in the fatal case.

Published
2021

37. Translating Unconventional T Cells and Their Roles in Leukemia Antitumor Immunity

Author

de Araújo, Nilberto Dias, Gama, Fábio Magalhães, de Souza Barros, Mateus, Ribeiro, Thaís Lohana Pereira, Alves, Fabíola Silva, Xabregas, Lilyane Amorim, Tarragô, Andréa Monteiro, Malheiro, Adriana, and Costa, Allyson Guimarães

Subjects
Article Subject
Abstract

Recently, cell-mediated immune response in malignant neoplasms has become the focus in immunotherapy against cancer. However, in leukemia, most studies on the cytotoxic potential of T cells have concentrated only on T cells that recognize peptide antigens (Ag) presented by polymorphic molecules of the major histocompatibility complex (MHC). This ignores the great potential of unconventional T cell populations, which include gamma-delta T cells (γδ), natural killer T cells (NKT), and mucosal-associated invariant T cells (MAIT). Collectively, these T cell populations can recognize lipid antigens, specially modified peptides and small molecule metabolites, in addition to having several other advantages, which can provide more effective applications in cancer immunotherapy. In recent years, these cell populations have been associated with a repertoire of anti- or protumor responses and play important roles in the dynamics of solid tumors and hematological malignancies, thus, encouraging the development of new investigations in the area. This review focuses on the current knowledge regarding the role of unconventional T cell populations in the antitumor immune response in leukemia and discusses why further studies on the immunotherapeutic potential of these cells are needed.

Published
2021
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38. Increased vulnerability to SARS-CoV-2 infection among indigenous peoples living in the urban area of Manaus

Author

Pontes, Gemilson Soares, primary, de Melo Silva, Jean, additional, Pinheiro-Silva, Renato, additional, Barbosa, Anderson Nogueira, additional, Santos, Luciano Cardenes, additional, de Pádua Quirino Ramalho, Antônio, additional, de Castro Alves, Carlos Eduardo, additional, da Silva, Danielle Furtado, additional, de Oliveira, Leonardo Calheiros, additional, da Costa, Allyson Guimarães, additional, and Bruno, Ana Carla, additional

Published
2021
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39. Single-Nucleotide Variants in the AIM2 – Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis

Author

Figueira, Mariana Brasil de Andrade, primary, de Lima, Dhêmerson Souza, additional, Boechat, Antonio Luiz, additional, Filho, Milton Gomes do Nascimento, additional, Antunes, Irineide Assumpção, additional, Matsuda, Joycenéa da Silva, additional, Ribeiro, Thaís Rodrigues de Albuquerque, additional, Felix, Luana Sousa, additional, Gonçalves, Ariane Senna Fonseca, additional, da Costa, Allyson Guimarães, additional, Ramasawmy, Rajendranath, additional, Pontillo, Alessandra, additional, Ogusku, Mauricio Morishi, additional, and Sadahiro, Aya, additional

Published
2021
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40. Immunological Hallmarks of Inflammatory Status in Vaso-Occlusive Crisis of Sickle Cell Anemia Patients

Author

Silva-Junior, Alexander Leonardo, primary, Garcia, Nadja Pinto, additional, Cardoso, Evilázio Cunha, additional, Dias, Stephanny, additional, Tarragô, Andrea Monteiro, additional, Fraiji, Nelson Abrahim, additional, Gomes, Matheus Souza, additional, Amaral, Laurence Rodrigues, additional, Teixeira-Carvalho, Andréa, additional, Martins-Filho, Olindo Assis, additional, De Paula, Erich Vinicius, additional, Costa, Allyson Guimarães, additional, and Malheiro, Adriana, additional

Published
2021
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41. Association of cfDNA levels and bothrops envenomation

Author

de Souza Barbosa, Êndila, primary, Santos Ibiapina, Hiochelson Najibe, additional, Rocha da Silva, Siuhelem, additional, Costa, Allyson Guimarães, additional, Val, Fernando Fonseca, additional, Mendonça-da-Silva, Iran, additional, Carlos de Lima Ferreira, Luiz, additional, Sartim, Marco Aurélio, additional, Monteiro, Wuelton Marcelo, additional, Cardoso de Melo, Gisely, additional, and de Almeida Gonçalves Sachett, Jacqueline, additional

Published
2021
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42. Adjunct N-Acetylcysteine Treatment in Hospitalized Patients With HIV-Associated Tuberculosis Dampens the Oxidative Stress in Peripheral Blood: Results From the RIPENACTB Study Trial

Author

Safe, Izabella P., primary, Amaral, Eduardo P., additional, Araújo-Pereira, Mariana, additional, Lacerda, Marcus V. G., additional, Printes, Vitoria S., additional, Souza, Alexandra B., additional, Beraldi-Magalhães, Francisco, additional, Monteiro, Wuelton M., additional, Sampaio, Vanderson S., additional, Barreto-Duarte, Beatriz, additional, Andrade, Alice M. S., additional, Spener-Gomes, Renata, additional, Costa, Allyson Guimarães, additional, Cordeiro-Santos, Marcelo, additional, and Andrade, Bruno B., additional

Published
2021
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43. Bee sting envenomation severe cases in Manaus, Brazilian Amazon: clinical characteristics and immune markers of case reports

Author

Mendonça-da-Silva, Iran, primary, Monteiro, Wuelton Marcelo, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Barbosa, Endila Souza, additional, Cordeiro-dos-Santos, Marcelo, additional, Lacerda, Marcus Vinícius Guimarães, additional, Melo, Gisely Cardoso, additional, Costa, Allyson Guimarães, additional, and Val, Fernando Fonseca Almeida, additional

Published
2021
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44. Severe tissue complications in patients of Bothrops snakebite at a tertiary health unit in the Brazilian Amazon: clinical characteristics and associated factors

Author

Silva, Flavio Souza, primary, Ibiapina, Hiochelson Najibe Santos, additional, Neves, Juliana Costa Ferreira, additional, Coelho, Kerolaine Fonseca, additional, Barbosa, Fabiane Bianca Albuquerque, additional, Lacerda, Marcus Vinicius Guimarães, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2021
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45. Development of an immunoassay for the detection of human IgG against hepatitis C virus proteins using magnetic beads and flow cytometry

Author

Neves, Walter Luiz Lima, primary, Mariuba, Luis André Morais, additional, Alves, Késsia Caroline Souza, additional, Coelho, Kerolaine Fonseca, additional, Tarragô, Andrea Monteiro, additional, Costa, Allyson Guimarães, additional, Chaves, Yury Oliveira, additional, Victoria, Flamir da Silva, additional, Victoria, Marilu Barbieri, additional, and Malheiro, Adriana, additional

Published
2020
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46. Impact ofPlasmodium vivaxmalaria and antimalarial treatment on cytochrome P450 activity in Brazilian patients

Author

Almeida, Anne Cristine, primary, Elias, Anna Beatriz Ribeiro, additional, Marques, Maria Paula, additional, Melo, Gisely Cardoso, additional, Costa, Allyson Guimarães, additional, Figueiredo, Erick Frota Gomes, additional, Brasil, Larissa Wanderley, additional, Rodrigues‐Soares, Fernanda, additional, Monteiro, Wuelton Marcelo, additional, Lacerda, Marcus Vinicius Guimarães, additional, Lanchote, Vera Lucia, additional, and Suarez‐Kurtz, Guilherme, additional

Published
2020
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47. Neutralization of the edema-forming and myotoxic activities of the venom of Potamotrygon motoro Müller and Henle, 1841 (Chondrichthyes – Potamotrygoninae) by antivenoms and circulating immunoglobulins

Author

Lameiras, Juliana Luiza Varjão, primary, de Moura, Valéria Mourão, additional, Dias, Lucas Castanhola, additional, Pessoa Júnior, Evandro Rezende, additional, Mallmann, Cacilda Satomi Yano, additional, Costa, Allyson Guimarães, additional, Lasmar, Michella Lima, additional, Nunez, Cecilia Veronica, additional, da Costa, Oscar Tadeu Ferreira, additional, and Dos-Santos, Maria Cristina, additional

Published
2020
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48. Feasibility of GeneXpert® Edge for Tuberculosis Diagnosis in Difficult-to-Reach Populations: Preliminary Results of a Proof-of-Concept Study

Author

Cordeiro-Santos, Marcelo, primary, Pinheiro, Jair dos Santos, additional, Spener-Gomes, Renata, additional, Souza, Alexandra Brito de, additional, Rodrigues, Maria Gabriela de Almeida, additional, Silva, Jayne Marina Pinto da, additional, Jesus, Jaquelane Silva, additional, Sacramento, Daniel Souza, additional, Brito, Artemir Coelho de, additional, Bastos, Mayara Lisboa Soares de, additional, Costa, Allyson Guimarães, additional, and Trajman, Anete, additional

Published
2020
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49. Immunologic Biomarkers, Morbidity and Mortality Among HIV Patients Hospitalized in a Tertiary Care Hospital in the Brazilian Amazon

Author

Mota, Wellington Gama, primary, Almeida, Taynná Vernalha Rocha, additional, Santos, Daniel Silva dos, additional, Chaves, Yury Oliveira, additional, Silva, Danielle Furtado da, additional, Orlandi, Patrícia Puccinelli, additional, Pereira, Flávio Ribeiro, additional, Magalhães, Gleicienne, additional, Baptista, Bárbara Jóse, additional, Frank, Carlos Henrique Michiles, additional, Silva, Viviane Lago de Oliveira, additional, Balieiro, Antônio Alcirley da Silva, additional, Santana, Monique Freire, additional, Gonçalves, Roberta Lins, additional, Costa, Allyson Guimarães da, additional, Santos, Marcelo Cordeiro dos, additional, Ferreira, Luís Carlos de Lima, additional, Lacerda, Marcus Vinicius Guimaraes, additional, and Nogueira, Paulo Afonso, additional

Published
2020
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50. Correlating Fibrinogen Consumption and Profiles of Inflammatory Molecules in Human Envenomation's by Bothrops atrox in the Brazilian Amazon

Author

Wellmann, Irmgardt Alicia María, primary, Ibiapina, Hiochelson Najibe Santos, additional, Sachett, Jacqueline Almeida Gonçalves, additional, Sartim, Marco Aurélio, additional, Silva, Iran Mendonça, additional, Oliveira, Sâmella Silva, additional, Tarragô, Andréa Monteiro, additional, Moura-da-Silva, Ana Maria, additional, Lacerda, Marcus Vinícius Guimarães, additional, Ferreira, Luiz Carlos de Lima, additional, Malheiro, Adriana, additional, Monteiro, Wuelton Marcelo, additional, and Costa, Allyson Guimarães, additional

Published
2020
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