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423 results on '"Cossu, Sergio"'

12. Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis

Author

Sanges, Francesca, Floris, Matteo, Cossu-Rocca, Paolo, Muroni, Maria R., Pira, Giovanna, Urru, Silvana Anna Maria, Barrocu, Renata, Gallus, Silvano, Bosetti, Cristina, D’Incalci, Maurizio, Manca, Alessandra, Uras, Maria Gabriela, Medda, Ricardo, Sollai, Elisabetta, Murgia, Alma, Palmas, Dolores, Atzori, Francesco, Zinellu, Angelo, Cambosu, Francesca, Moi, Tiziana, Ghiani, Massimo, Marras, Vincenzo, Santona, Maria Cristina, Canu, Luisa, Valle, Enrichetta, Sarobba, Maria Giuseppina, Onnis, Daniela, Asunis, Anna, Cossu, Sergio, Orrù, Sandra, and De Miglio, Maria Rosaria

Published
2020
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19. A prospective non-randomized controlled, multicenter trial comparing Appendectomy and Conservative Treatment for Patients with Uncomplicated Acute Appendicitis (the ACTUAA study)

Author

Podda, Mauro, Serventi, Fernando, Mortola, Lorenzo, Marini, Stefano, Sirigu, Danilo, Piga, Michela, Pisano, Marcello, Coppola, Massimiliano, Agresta, Ferdinando, Virdis, Francesco, Di Saverio, Salomone, Cillara, Nicola, Balestra, Francesco, Ottonello, Roberto, Lai, Antonio, Piro, Silverio, Argenio, Giulio, Gemini, Sergio, Pala, Miriam, Piras, Mario, Erdas, Enrico, Nicolosi, Angelo, Gordini, Luca, Podda, Francesco, Pisanu, Adolfo, Atzeni, Jenny, Poillucci, Gaetano, De Nisco, Carlo, Casciu, Luigi, Piano, Maurizio, Labate, Salvatore, Saba, Luca, Aresu, Simona, Azzinnaro, Antonio, Ioia, Giovanna, Turri, Luciano, Pulighe, Fabio, Anania, Marco, Canfora, Alfonso, Bottino, Vincenzo, Piazza, Diego, Luridiana, Gianluigi, Serra, Piergiorgio, Saba, Alessandra, Tuveri, Antonio, Pinna, Giovanni, Piredda, Antonella, Madeddu, Francesco, Caneva, Patrizia Dalla, Delogu, Daniele, Saliu, Antonella, Cogoni, Gianfranco, Deserra, Antonello, Pau, Renata, Cossu, Sergio, Canu, Luisa, Marcias, Gianni, Garau, Franco, Loi, Salvatore, Bellisano, Giulia, Presenti, Luigi, Maccioni, Antonio, Norcia, Giorgio, Piras, Emanuele, Fiume, Stefania, Pitzalis, Antonella, Bianco, Paola, Cappai, Mariangela, Cadeddu, Flavio Nicola, Manca, Alessandra, Occhioni, Giovanni, Rossi, Arianna Magoni, Rizzo, Salvatore, Centonze, Maurizio, Portolano, Vincenzo, Barbareschi, Mattia, Barrasi, Elena, Martorana, Martina, Ferro, Franca, Casarini, Claudia, Stella, Giorgio, Generoso, Paola, Rossi, Sabina, Abelli, Fabrizio, Casula, Laura, Gerardi, Chiara, Bertele’, Vittorio, and The ACTUAA Study Collaborative Working Group

Published
2017
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23. Application of a Participatory Process for the Selection of Adaptation Actions in the Context of Rural and Forest Fires: Preliminary Results from the Experience Conducted within the Italy–France Maritime MED-Star Project

Author

Bacciu, Valentina, primary, Marras, Serena, additional, Mereu, Valentina, additional, Funaro, Matteo, additional, Mongili, Silvia, additional, Cossu, Sergio, additional, Meloni, Giampaolo, additional, Masu, Francesca, additional, Pira, Virginia Cristina, additional, and Spano, Donatella, additional

Published
2022
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26. Durability of left bundle branch area pacing

Author

Mehta, Nikhil A., primary, Saqi, Bilal, additional, Sabzwari, Syed R. A., additional, Gupta, Rahul, additional, Vyas, Apurva, additional, Gordon, Jeffrey, additional, Cossu, Sergio, additional, Nazir, Talha, additional, Freudenberger, Ronald, additional, and Bozorgnia, Babak, additional

Published
2022
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34. Enantioseparation of 5,5'-Dibromo-2,2'-Dichloro-3-Selanyl-4,4'-Bipyridines on Polysaccharide-Based Chiral Stationary Phases: Exploring Chalcogen Bonds in Liquid-Phase Chromatography

Author

Peluso, Paola, Dessì, Alessandro, Dallocchio, Rober, Sechi, Barbara, Gatti, Carlo, Chankvetad, Bezhan, Mamane, Victor, Weiss, Robin, Pale, Patrick, Aubert, Emmanuel, Cossu, Sergio, Ghanem, Ashraf, Mcphee, Derek, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche (CNR), Istituto di Scienze e Tecnologie Chimiche 'G. Natta' (CNR-SCITEC), Milan, Tbilisi State University, Institut de Chimie de Strasbourg, Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Institut de Chimie du CNRS (INC), Cristallographie, Résonance Magnétique et Modélisations (CRM2), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and University of Ca’ Foscari [Venice, Italy]

Subjects
Pyridines, Pharmaceutical Science, Crystal engineering, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Nucleophile, Heterocyclic Compounds, Drug Discovery, Settore CHIM/01 - Chimica Analitica, Physics::Chemical Physics, chalcogen bond, ComputingMilieux_MISCELLANEOUS, Settore CHIM/02 - Chimica Fisica, Chemistry, enantioseparation, Stereoisomerism, 3. Good health, Chemistry (miscellaneous), Electrophile, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Thermodynamics, Molecular Medicine, bipyridines, polysaccharide-based chiral stationary phases, Static Electricity, Supramolecular chemistry, Substituent, 010402 general chemistry, Ring (chemistry), Article, lcsh:QD241-441, Chalcogen, lcsh:Organic chemistry, high-performanceliquid chromatography, Polysaccharides, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Physics::Atomic and Molecular Clusters, bipyridines, chalcogen bond, electrostatic potential, enantioseparation, high-performanceliquid chromatography, polysaccharide-based chiral stationary phases, Physical and Theoretical Chemistry, high-performance liquid chromatography, Lone pair, Chromatography, 010405 organic chemistry, Organic Chemistry, Settore CHIM/06 - Chimica Organica, 0104 chemical sciences, electrostatic potential, Chalcogens, Chromatography, Liquid
Abstract

The chalcogen bond (ChB) is a noncovalent interaction based on electrophilic features of regions of electron charge density depletion (&sigma, holes) located on bound atoms of group VI. The &sigma, holes of sulfur and heavy chalcogen atoms (Se, Te) (donors) can interact through their positive electrostatic potential (V) with nucleophilic partners such as lone pairs, &pi, clouds, and anions (acceptors). In the last few years, promising applications of ChBs in catalysis, crystal engineering, molecular biology, and supramolecular chemistry have been reported. Recently, we explored the high-performance liquid chromatography (HPLC) enantioseparation of fluorinated 3-arylthio-4,4&prime, bipyridines containing sulfur atoms as ChB donors. Following this study, herein we describe the comparative enantioseparation of three 5,5&prime, dibromo-2,2&prime, dichloro-3-selanyl-4,4&prime, bipyridines on polysaccharide-based chiral stationary phases (CSPs) aiming to understand function and potentialities of selenium &sigma, holes in the enantiodiscrimination process. The impact of the chalcogen substituent on enantioseparation was explored by using sulfur and non-chalcogen derivatives as reference substances for comparison. Our investigation also focused on the function of the perfluorinated aromatic ring as a &pi, hole donor recognition site. Thermodynamic quantities associated with the enantioseparation were derived from van&rsquo, t Hoff plots and local electron charge density of specific molecular regions of the interacting partners were inspected in terms of calculated V. On this basis, by correlating theoretical data and experimental results, the participation of ChBs and &pi, hole bonds in the enantiodiscrimination process was reasonably confirmed.

Published
2021

37. Additional file 1 of Histologic subtyping affecting outcome of triple negative breast cancer: a large Sardinian population-based analysis

Author

Sanges, Francesca, Floris, Matteo, Cossu-Rocca, Paolo, Muroni, Maria R., Pira, Giovanna, Urru, Silvana Anna Maria, Barrocu, Renata, Gallus, Silvano, Bosetti, Cristina, D’Incalci, Maurizio, Manca, Alessandra, Uras, Maria Gabriela, Medda, Ricardo, Sollai, Elisabetta, Murgia, Alma, Palmas, Dolores, Atzori, Francesco, Zinellu, Angelo, Cambosu, Francesca, Moi, Tiziana, Ghiani, Massimo, Marras, Vincenzo, Santona, Maria Cristina, Canu, Luisa, Valle, Enrichetta, Sarobba, Maria Giuseppina, Onnis, Daniela, Asunis, Anna, Cossu, Sergio, Orrù, Sandra, and Miglio, Maria Rosaria De

Abstract

Additional file 1: Figure S1. Violin plot of tumor size distribution according to “Triple Negative” breast cancer histologic types. Table S1. Correlation between tumor size and number of metastatic lymph nodes in different histologic types of “Triple Negative” breast cancer. Sardinia, Italy 1994–2015. Figure S2. Correlation between tumor size and number of positive lymph nodes in “Triple Negative” breast cancer histologic types. A linear regression model constructs the regression lines. The slope of the regression line symbolizes the average increase in the number of metastatic lymph nodes for each millimeter increase in tumor size for each histologic TNBC types, indicative of the influence of tumor size on number of metastatic lymph nodes.

Published
2020
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43. Unexpected formation of dienes in the Diels-Alder reaction of exocyclic 1-bromobutadienes of polycyclic hydrocarbons

Author

Cossu, Sergio, Cuomo, Giancarlo, De Lucchi, Ottorino, Maggini, Michele, and Valle, Giovanni

Subjects
Organic compounds -- Research, Diels-Alder reaction -- Research, Butadiene -- Research, Polycyclic aromatic hydrocarbons -- Research, Biological sciences, Chemistry
Abstract

Experiments to study the Diels-Alder reactions of exocyclic 1-bromobutadiene with dienophiles and buckminsterfullerene were carried out as part of a study on polycyclic olefin synthesis. The reaction, which involves a tandem cycloaddition-elimination process, yielded dienes exclusively. With the exception of polycyclic dienes and 4-phenyl-1,2,4-triazoline-3,5-dione, all the reactions failed to produce any primary or secondary adducts.

Published
1996

44. Additional file 1: Table S1. of Clinical and pathological factors influencing survival in a large cohort of triple-negative breast cancer patients

Author

Urru, Silvana, Gallus, Silvano, Bosetti, Cristina, Moi, Tiziana, Medda, Ricardo, Sollai, Elisabetta, Murgia, Alma, Sanges, Francesca, Pira, Giovanna, Manca, Alessandra, Palmas, Dolores, Floris, Matteo, Asunis, Anna, Atzori, Francesco, Carru, Ciriaco, D’Incalci, Maurizio, Ghiani, Massimo, Marras, Vincenzo, Onnis, Daniela, Santona, Maria, Sarobba, Giuseppina, Valle, Enrichetta, Canu, Luisa, Cossu, Sergio, Bulfone, Alessandro, Rocca, Paolo, Miglio, Maria De, and Orrù, Sandra

Abstract

Hazard ratios (HRs) of recurrence, and corresponding 95% confidence intervals (CIs), according to selected clinical and pathological characteristics, among 825 triple-negative breast cancers (TNBCs). Sardinia, Italy 1994-2015. Table S2. Hazard ratios (HRs) of recurrence, and corresponding 95% confidence intervals (CIs), according to pathological lymph nodes and lymph node ratio among 311 triple-negative breast cancers (TNBCs) with positive lymph nodes. Sardinia, Italy 1994-2015. Figure S1. Kaplan-Meir curves for disease-free survival according to tumor stage among 825 triple-negative breast cancer patients. Sardinia, Italy 1994â 2005. Figure S2. Kaplan-Meir curves for disease-free survival according to pathological lymph nodes stage (a) and lymph node ratio (b) among 311 triple-negative breast cancer patients with positive lymph nodes. Sardinia, Italy 1994â 2005 (DOC 658 kb)

Published
2018
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49. Recent trends and applications in liquid phase chromatography enantioseparation of atropisomers

Author

Peluso, Paola, Mamane, Victor, Aubert, Emmanuel, Cossu, Sergio, University of Sassari, Institut de Chimie de Strasbourg, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Cristallographie, Résonance Magnétique et Modélisations (CRM2), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), University of Ca’ Foscari [Venice, Italy], and Université de Strasbourg (UNISTRA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, Chiral stationary phase, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Settore CHIM/06 - Chimica Organica, Dynamic chromatography, Atropisomerism, Enantioseparation, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Settore CHIM/09 - Farmaceutico Tecnologico Applicativo, [CHIM.COOR]Chemical Sciences/Coordination chemistry, Settore CHIM/01 - Chimica Analitica, HPLC, ComputingMilieux_MISCELLANEOUS, Atropisomerism, Chiral stationary phase, Dynamic chromatography, Enantioseparation, HPLC
Abstract

International audience

Published
2017

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