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2. Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or infliximab

Author

Laharie, D, Bourreille, A, Branche, J, Allez, M, Bouhnik, Y, Filippi, J, Zerbib, F, Savoye, G, Vuitton, L, Moreau, J, Amiot, A, Cosnes, J, Ricart, E, Dewit, O, Lopez-Sanroman, A, Fumery, M, Carbonnel, F, Bommelaer, G, Coffin, B, Roblin, X, van Assche, G, Esteve, M, Farkkila, M, Gisbert, JP, Marteau, P, Nahon, S, de Vos, M, Lambert, J, Mary, JY, and Louis, E

Published
2018
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3. Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Author

Sazonovs, A., Stevens, C.R., Venkataraman, G.R., Yuan, K., Avila, B., Abreu, M.T., Ahmad, T., Allez, M., Ananthakrishnan, A.N., Atzmon, G., Baras, A., Barrett, J.C., Barzilai, N., Beaugerie, L., Beecham, A., Bernstein, C.N., Bitton, A., Bokemeyer, B., Chan, A., Chung, D., Cleynen, I., Cosnes, J., Cutler, D.J., Daly, A., Damas, O.M., Datta, L.W., Dawany, N., Devoto, M., Dodge, S., Ellinghaus, E., Fachal, L., Farkkila, M., Faubion, W., Ferreira, M., Franchimont, D., Gabriel, S.B., Ge, T., Georges, M., Gettler, K., Giri, M., Glaser, B., Goerg, S., Goyette, P., Graham, D., Hamalainen, E., Haritunians, T., Heap, G.A., Hiltunen, M., Hoeppner, M., Horowitz, J.E., Irving, P., Iyer, V., Jalas, C., Kelsen, J., Khalili, H., Kirschner, B.S., Kontula, K., Koskela, J.T., Kugathasan, S., Kupcinskas, J., Lamb, C.A., Laudes, M., Levesque, C., Levine, A.P., Lewis, J.D., Liefferinckx, C., Loescher, B.S., Louis, E., Mansfield, J., May, S., McCauley, J.L., Mengesha, E., Mni, M., Moayyedi, P., Moran, C.J., Newberry, R.D., O'Charoen, S., Okou, D.T., Oldenburg, B., Ostrer, H., Palotie, A., Paquette, J., Pekow, J., Peter, I., Pierik, M.J., Ponsioen, C.Y., Pontikos, N., Prescott, N., Pulver, A.E., Rahmouni, S., Rice, D.L., Saavalainen, P., Sands, B., Sartor, R.B., Schiff, E.R., Schreiber, S., Schumm, L.P., Segal, A.W., Seksik, P., Shawky, R., Sheikh, S.Z., Silverberg, M.S., Simmons, A., Skeiceviciene, J., Sokol, H., Solomonson, M., Somineni, H., Sun, D., Targan, S., Turner, D., Uhlig, H.H., Meulen, A.E. van der, Vermeire, S., Verstockt, S., Voskuil, M.D., Winter, H.S., Young, J., Duerr, R.H., Franke, A., Brant, S.R., Cho, J., Weersma, R.K., Parkes, M., Xavier, R.J., Rivas, M.A., Rioux, J.D., McGovern, D.P.B., Huang, H.L., Anderson, C.A., Daly, M.J., Belgium IBD Consortium, Cedars-Sinai IBD, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, NIHR IBD BioResource, Regeneron Genetics Center, SHARE Consortium, SPARC IBD Network, UK IBD Genetics Consortium, Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: NUTRIM - R2 - Liver and digestive health, Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
Crohn Disease, Genetics, Humans, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Article, Genome-Wide Association Study
Abstract

Genome-wide association studies (GWASs) have identified hundreds of loci associated with Crohn's disease (CD). However, as with all complex diseases, robust identification of the genes dysregulated by noncoding variants typically driving GWAS discoveries has been challenging. Here, to complement GWASs and better define actionable biological targets, we analyzed sequence data from more than 30,000 patients with CD and 80,000 population controls. We directly implicate ten genes in general onset CD for the first time to our knowledge via association to coding variation, four of which lie within established CD GWAS loci. In nine instances, a single coding variant is significantly associated, and in the tenth, ATG4C, we see additionally a significantly increased burden of very rare coding variants in CD cases. In addition to reiterating the central role of innate and adaptive immune cells as well as autophagy in CD pathogenesis, these newly associated genes highlight the emerging role of mesenchymal cells in the development and maintenance of intestinal inflammation.Large-scale sequence-based analyses identify novel risk variants and susceptibility genes for Crohn's disease, and implicate mesenchymal cell-mediated intestinal homeostasis in disease etiology.

Published
2022

7. Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

Author

Bourrier, A., Carrat, F., Colombel, J.-F., Bouvier, A.-M., Abitbol, V., Marteau, P., Cosnes, J., Simon, T., Peyrin-Biroulet, L., Beaugerie, L., Gendre, Jean-Pierre, Lémann, Marc, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Laharie, David, Dupas, Jean Louis, Flourié, Bernard, Lerebours, Eric, Allez, Matthieu, Messing, Bernard, Cadiot, Guillaume, Soulé, Jean-Claude, Gornet, Jean-Marc, Veyrac, Michel, Duclos, Bernard, Beau, Philippe, Bourreille, Arnaud, Baumer, Philippe, Carbonnel, Franck, Heresbach, Denis, Metman, Etienne-Henry, Florent, Christian, Blain, Antoine, Faucheron, Jean-Luc, Bonaz, Bruno, Roblin, Xavier, Potier, Pascal, Boehm, Christian, Kurtz, Thierry, Lamouliatte, Hervé, Nion-Larmurier, Isabelle, Delchier, Jean-Charles, Chaussade, Stanislas, Weiss, Anne Marie, Cézard, Jean Pierre, Siproudhis, Laurent, Nahon, Stéphane, Sondag, Daniel, Jian, Raymond, Souquet, Jean-Christophe, Bord, Pierre, Coffin, Benoit, Dʼalmagne, Hélène, Delasalle, Patrick, Fournier, Régis, Cavicchi, Maryan, Souffran, Marc-Henry, Vandromme, Luc, Guedon, Claire, Seksik, Philippe, Michiels, Christophe, Renard, Pascal, Rogier, Patrice, Gouilloud, Sylvie, Rotenberg, André, Savoye, Guillaume, Thevenin, Alain, Mallet, Laurent, Brazier, Franck, Jean, Francois, Justum, Anne-Marie, Latrive, Jean-Paul, Gerbal, Jean-Luc, Pierrugues, Robert, Chardonnal, Gérard, Picon, Laurence, Reix, Nicole, Dʼaubigny, Nicolas Drouët, Uettwiller, Hervé, Mallet, Anne Courillon, Palacci, Alain, Bensaude, Raoul-Jacques, Bonniaud, Pierre, Empinet, Olivier, Nisard, Andrée, Rudelli, Alain, Tubiana, Bernard, Capelle, Philippe, Dabadie, Alain, Evard, Daniel, Julien, Pierre-Emile, Picon-Coste, Magali, Schneider, Stéphane, Goldfain, Denis, Bellanger, Jérôme, Blondelot, Jean-Pierre, Lamy, Philippe, Lemière, Sébastien, Mockly, Jean Francois, Pellat, Benoit, Gatineau-Sailliant, Gilles, Nalet, Bernard, Nancey, Stéphane, Kusielewicz, Daniel, Loison, Patrick, Popot, Jean-Michel, Merite, François, Roux, Jean-Pol, Afchain, Pauline, Blanquart, Alain, Heyries, Laurent, Reville, Marc, Viron, Dominique, Zerbib, Frank, Claviere, Christophe, Léostic, Didier, Pouderoux, Philippe, Moitry, Alain, Hagège, Hervé, Hugot, Jean-Pierre, Humeau, Benoit, Sabate, Jean-Marc, Lederman, Emmanuel, Lescut, Dominique, Luneau, Fabrice, Mesnard, Bruno, Smadja, Lionel, Steinberg, Michel, Brun, Marc, Macaigne, Gilles, Marchal, Jean Luc, Ollivier, Stéphane, Ouvry, Dominique, Perche, Jean Paul, Rambaud, Serge, Benamouzig, Robert, Cazenave, Jean Louis, Coffin, Jean-Charles, Blazquez, Martine, Lagneau, Marion, Person, Bruno, Wittersheim, Christian, Napoleon, Bertrand, Cemachovic, Israël, Iglicki, Franck, Howaizi, Mehran, Leprince, Eric, Leurent, Bruno, Morin, Thierry, Darsouni, Riad, Attar, Alain, Baron, Philippe, Breton, Anne, Gillion, Jean Marie, Guemene, Jean-Marc, Jouffre, Claude, Moreau, Xavier, Claude, Pierre, Quinton, André, Brichard, Jean Michel, Desaint, Benoit, Bouygues, Martin, Chatrenet, Philippe, Salmeron, Marcelo, Silvie, Jean, Waldner, Bruno, Emery, Yves, Moraillon, Armand, Kunkel, Daniel, Dubois, Philippe, Faure, Patrick, LʼHirondel, Christian, Labérenne, Jean-Eric, Moreau, Pierre, Pereira, Adelino, Plihon, Genevieve, Wolff, Thierry, Ngo, Yann, Boruchowicz, Arnaud, Jost, Béatrice, Gotlib, Jean Pierre, Danne, Odile, Raoux, Philippe, Ramond-Bouhali, Marie-José, Baetz, Andre, Veyres, Bruno, Chapoutot, Christian, Le Dréau, Gérard, Filippi, Jérôme, Mudry, Jean, Kalt, Philippe, Minault, Sophie, Bounin, Pierre-André, Andréani, Tony, Charneau, Jacky, Reijasse, Didier, Bolze, Jean-Louis, Thaunat, Jean Luc, Le Couteulx, Christian, Maurage, Chantal, Bader, Robert, Codjovi, Philippe, Migairou, Jean-Luc, Morali, Alain, Rey, Philippe, Molard, Bruno Richard, Petit, Richard, Koch, Stéphane, Cassan, Philippe, Deschamps, Jean-Paul, Caby, Christine Meicler, Meurisse, Jean-Jacques, Prades, Philippe, Boulant, James, Diacono, Michel, Monsch, Jean-Marie, Dupuy, J-François, Bellaiche, Guy, Guegan, Martine, Comte, Jean-Marc, Cayla, Jean-Michel, Le Tallec, Francois, Meurisse, Franck, Desurmont, Philippe, Roget, Laurent, Bouyssou, Philippe, Le Gall, Bruno, Bloch, Francis, Larvol, Loic, Jullien, Monique, Moreau, Jacques, Rebouissoux, Laurent, Decroix, Bruno, Dib, Nina, Dieterling, Paul, Lenormand, Frédéric, Lagier, Emmanuel, Fallourd, Philippe, Charpin, Serge, Bertrand, Hugues, Bommelaer, Gilles, Battistelli, Daniel, Delon, Bernard, Dentant, Lionel, Dorval, Etienne, Dumortier, Jérôme, Gaye-Bareyt, Eric, Gerosa, Yves, Guez, Chantal, Mornet, Martine, Benfredj, Paul, Piperaud, René, Stremsdoerfer, Noel, Verdier, Eric, Grinholtz, Alain, Barjonet, Georges, See, Antoine, Arotçarena, Ramuntxo, Baudet, Anne, Broyer, Joel, Charachon, Antoine, Blondon, Hugues, Mouton, Pascal, Claudez, Hubert, Labat-Labourdette, Jacques, Haëm, Jacques, Estable, Patrick, Levy, Patrick, Rosenbaum, Alain, Balavoine, Yvon, Blanchi, Alain, Coutarel, Pierre, Delaperriere, Nadege, Dervichian, Michel, Marois, Francis, Seroka, Jacques, Michaud, Laurent, Leroy, Olivier, Meyran, Emmanuel, Poilroux, Bernard, Tensaouti, Abdallah, Paupard, Thierry, Agard, Dominique, Beaulieu, Sandrine, Benfiguig, Kader, Capony, Patrice, Cottereau, Jean, Desreumaux, Pierre, Dramard, Jean-Michel, Duché, Mathieu, Mamou, Patrick, Etienney, Isabelle, DʼAbrigeon, Gilles, Godeberge, Béatrice, Tucat, Gilbert, Puech, Jean, Roger, Jean, Lapalus, Marie-George, Bauret, Paul, Houcke, Philippe, Pornin, Béatrice, Champigneulle, Bruno, Cuissard, Laurent, David, Xavier-Richard, Lombard, Frédéric, Granveau, Antoine, Hamon, Jean-François, Ink, Olivier, Blondel, Fabienne, Namias, Alain, Pillon, Didier, Reignier, Antoine, Tordjman, Gilles, Christidis, Christos, Zirabe, Simon, Audebert, Michel, Bion, Eric, Bourgeaux, Claude, Poupardin, Cécile, Deplaix, Philippe, Fratini, Gérard, Garnier, Thierry, Desseaux, Gerard, Magois, Hervé, Lochum, Sylvain, Vergier, Jean-Francois, Texereau, Patrick, Rat, Christel, Uzzan, Francoise, Vidal, Alain, Vinante, Nadia, Watrin, Bernard, Wurtz-Huckert, Cécile, Barre, Bruno, Ferbus, Dominique Chaslin, Contou, Jean-François, Coupier, Dominique, David, Benoit, Gargot, Dany, Huc, Denis, Barraya, Remy, Faroux, Roger, Fourgeaud, Jean-Luc, Grimprel, Hubert, Auroux, Jean, Rey, Jean-François, Arnoux, Jean Pierre, Lentini, Franck, Tardy, Ludovic, Mouterde, Olivier, Spyckerelle, Claire, Vacherot, Bruno, Weissman, Alain, Alpérine, Michel, Le Sidaner, Anne, Bonnet-Eymard, Pierre-Olivier, Colson, Jean Louis, Pellet, Daniel, Deltombe, Bernard, Edouard, André, Maechel, Henri, Jaillet, Jean-Claude, Genes, Julien, Leveque, Anne-Marie, Lucidarme, Damien, Maignan, Philippe, Gehrke, Nathalie Mallier, Sanchez, Jérôme, Tusseau, Frank, Casteur, Alban, Bottlaender, Jacques, Constantini, Denis, Coton, Thierry, Even, Philippe, Druart, Francois, Riot, François, Gauchet, Jean-Michel, Hecquet, Geneviève, Henry, Gerard, Hochain, Patrick, Arpurt, Jean Pierre, Medini, Abdelkrim, Dartois-Hoguin, Michele, Moindrot, Henri, Emery, Philippe, Periac, Pierre, Prunier, Annie, Renkes, Pascal, Tawil-Longreen, Christine, Vincent, Edmond, Vitte, René-Louis, Loeb, Christian, Carwana, Alain, Barbereau, Didier, Bohon, Philippe, Corrieri-Baizeau, Céline, Sahy, Daniel, Derreveaux, Philippe, David, Dominique, Desbazeille, François, Fontenelle, Patrick, Slama, Jean Luc, Le Mercier, Yvon, Certin, Michel, Reig, Jean Jacques, Rosa, Isabelle, Helbert, Thierry, Tounian, Patrick, Turner, Luc, Perot, Valéry, Aillet, Luc, Pauwels, Arnaud, Barré, Philippe, Nury, Bernard, Cazalbou, Claude, Devulder, Franck, Durget, Alain, Dubroca, Jeanne, Gaudy, Daniele, Greff, Michel, Jacques, Christian, Lafarge, Jocelyne, Kezachian, Gilles, Le Gall, Ronan, Pariente, Alex, Pinault, Tiphaine, Bismuth, Michaël, Boyer-Darrigrand, Nathalie, Bretagnolle, Philippe, Carpentier, Stephane, Cholet, Franck, Theodore, Christian, Combes, Rémi, Combet, Francois, Delanoe, Christophe, De Montigny, Stéphanie, Soudan, Denis, Fourdan, Olivier, Minier, Gilles, Languepin, Jeanne, Roche, Jean, Ginies, Jean-Louis, Nouel, Olivier, Petitgars, Philippe, Robin, Edith, Hamm, Romain, Roques, Jean François, Roussin-Bretagne, Sylvie, Sénéjoux, Agnès, Muron, Sophie, Bardoux, Nicolas, Berthelemy, Philippe, Madonia, Patrick, Carles, Bertrand, Reynier, Catherine, Cuillerier, Emmanuel, Dadamessi, Innocenti, Danis, Jacques, Debenes, Bernard, Dubuc-Rey, Nathalie, Lesur, Gilles, Jouet, Pauline, Lenaerts, Catherine, Garret, Marc, Mineur, Alexandra, Chabry, Bernard, Pigot, Francois, Rossi, Valérie, Tennenbaum, Ruth, Salloum, Julien, Slaoui, Maurice Hakim, Mathieu, Stéphane, Papapietro, Valérie, Viola, Sheila, Bezet, Alexis, Altman, Claude, Audan, Alain, Calabet, Jean, Masliah, Claude, Fayemendy, Laurent, Duruy, Marc, Gauffeny, Benoit, Helie, Ludovic, Imani, Kamran, Janin-Manificat, Raoul, Galmiche, Jean-Paul, Kerlirzin, Anne, Bedenne, Laurent, Locher, Christophe, Michaudel, Gilles, Missonnier, Gilles, Rinaldi-Dovio, Michel, Rouillon, Jean-Michel, Ecuer, Stéphane, Patenotte, Arnaud, Bronstein, Jean Ariel, Baty, Vincent, Bougnol, Michel, Bourbon, Pierre, Cerbelaud, Philippe, Chavaillon, Annick, Boiffin, Franck, Dubern, Béatrice, De Laguierce, Isabelle Duval, Greco, Fernand, Bouhot, Florence, Godeberge, Philippe, Grandmaison, Brigitte, Gros, Pascal, Targues, Guy, Corallo, Jacques, Boutin, Jean, Guillan, Jacques, Barbieux, Jean Pierre, Lariviere, Isabelle Loury, Le Genissel, Henri, Leroi, Henri, Bellaiche, Marc, Elie-Legrand, Marie-Claire, Dapoigny, Michel, Denoyel, Philippe, Pienkowski, Patrice, Pouche, Philippe, Saurfelt, Marc Michel, Thorel, Jean Marie, Piche, Thierry, Travers, Bruno, Tuvignon, Patrick, Zalcberg, Marc, Boulay, Guy, Zamora, Christophe, Samama, Joelle, Ricotie, Etienne, De Fleury, Patrice, Maille, Francois, Mougenel, Jean Louis, Gonot, Olivier, Menat, Jean Philippe, Kaassis, Mehdi, Lang, Francoise, Abramowitz, Laurent, Ganne, Nathalie, Pecriaux, Olivier, Seyrig, Jacques-Arnaud, Sobhani, Iradj, Parmentier, Thierry, Van Nieuwenhuyse, Antoine, Weber, Francois-Xavier, Glibert, André, Bineau, Catherine, Canet, Bernard, Collin, Catherine, Cordet, Frederic, Parlier, David David, Carre, Dominique, Peytier, Annie, Fein, Francine, Barouk, Jerome, Dewannieux, Jacques, Hartwig, Johannes, Jouve, Jean-Louis, Laplane, Bertrand, Lascar, Gilles, Legrand, Christophe, Le Marchand, Pierre, Liebaert, Marie Pierre, Terdiman-Pire, Michele, Abdelli, Naceur, Neveu, Dominique, De La Lande, Philippe, De Saint Louvent, Patrick, Pelatan, Cécile, Petit, Agnès, Richecoeur, Martial, Texier, Frederic, Cazals, Jean Brice, Tissot, Bertrand, Mourrut, Christian, Doubremelle, Marie, Foltz, Marc, Gautier-Jubé, Florence, Martin, Jacques, Khouri, Elie, Lons, Thierry, Carlier-Bandu, Martine, Monnin, Jean-Luc, Roche, Hervé, Willemin, Bernard, Houard, Xavier, Fatisse, Abdelaziz, le Algard, Michè, Arab, Kamel, Borel, Isabelle, Lagarrigue, Cécile, Chryssostalis, Ariane, Boutroux, Dominique, Dupuychaffray, Jean-Pierre, Khaddari, Saïd, Mion, François, Puy-Montbrun, Thierry, Girardet, Jean-Philippe, Gury, Bruno, Landau, Alain, Le Bihan, Monique, Nieuviarts, Sandrine, Ollivry, Jean, Le Bourgeois, Philippe, Piquet, Marie-Astrid, Escartin, Michel-Pierre, Systchenko, Remi, Venezia, Franck, Wantiez, Michel, Lesage, Xavier, Zrihen, Elie, Aygalenq, Philippe, Dieumegard, Barbara, Savarieau, Bernard, Bulois, Philippe, Cattan, Stéphane, Diez, Jean-Lucien, Fauchot, Olivier, Durous, Eric, Gazut, Valérie, Guilleminet, Christian, Bories, Jean-Marc, Le Floch, Isabelle Joly, Vove, Jean-Paul, Lelouch, Stéphane, Lévy, Philippe, Lhopital, François, Marcato, Norma, Mozer-Bernardeau, Marianne, Nousbaum, Jean-Baptiste, Cattan, Philippe, Plane, Alain, Raymond, Jean-Michel, Roseau, Gilles, Rozental, Gerald, Boustière, Christian, Bonny, Corinne, Cordier-Collet, Mariepierre, Courat, Laurent, Croguennec, Bernard, Delaunay-Tardy, Karine, Labarriere, Damien, Geagea, Edmond, Gottrand, Frédéric, Gelsi, Eve, Thiefin, Gerard, Wohlschies, Eric, Miguet, Mathieu, Ponsot, Philippe, Suzanne, Jean, Teste, Yves, Gossart, Anne-Claire Dupont, Baroni, Jean-Luc, Benchaa, Benabdallah, Blanc, Georges, Maroy, Bernard, Bonjean, Philippe, Brézault, Catherine, Bridoux-Henno, Laure, Chayette, Claude, Auby, Dominique, Fiorucci, Robert, Galindo, Georges, Hubert, Gilles, Bonneau, Gilles, Marinier, Evelyne, Pouteau, Michele, Alamdari, Afchine, Delbende, Bruno, Chamouard, Patrick, DʼAbravanel, Pascale, DallʼOsto, Hélène, Hervé, Sophie, Lefebvre, Jean, Levoir, Damien, Lillo, Philippe, Rouch, Michel, Mathonnet, Muriel, De Lustrac, Mercédes, Ramond, François-Jean, Roupret, Bernard, and Soupison, Alain

Published
2016
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9. Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility

Author

Schuum P, Daniel B. Graham, Sun D, Seksik P, David T. Okou, Daniel L. Rice, David J. Cutler, Martti Färkkilä, Liefferinckx C, Segal Aw, Andrew T. Chan, Denis Franchimont, Beecham A, Subra Kugathasan, Stacey Gabriel, Stefan Schreiber, Baras A, Kirschner Bs, Goerg S, Juozas Kupcinskas, Jukka Koskela, John C. Mansfield, Kyle Gettler, Devoto M, Dobes A, Debby Laukens, Richard H. Duerr, Myriam Mni, Loescher B, Cosnes J, Mengesha E, William A. Faubion, Joshua Lewis, Graham A. Heap, Voskuil, Christine Stevens, Pekow J, Lisa W. Datta, Adam P. Levine, Khalili H, O’Charoen S, Dan Turner, Nikolas Pontikos, Natalie J. Prescott, Inga Peter, Marc P. Hoeppner, Chung D, Mark S. Silverberg, Dodge S, Talin Haritunians, Moayyedi P, Winter Hs, John D. Rioux, Andre Franke, Holm H. Uhlig, Ferreira M, Matthew Solomonson, Sokol H, Damas Om, Ramnik J. Xavier, Horowitz Je, Iyer, Eija Hämäläinen, Avila B, Dawany N, Newberry R, Bernstein C, Shawky R, Benjamin Glaser, Alison Simmons, Mamta Giri, Bruce E. Sands, Ann E. Pulver, Yuan K, Abreu Mt, Gil Atzmon, Allez M, Young J, Verstockt S, Aarno Palotie, Hongyan Huang, Kimmo Kontula, Ellinghaus E, van der Meulen Ae, Ahmad T, Oldenburg B, Cyriel Y. Ponsioen, Daly A, Dermot P.B. McGovern, Jeffrey C. Barrett, Peter M. Irving, Miles Parkes, Jacob L. McCauley, Päivi Saavalainen, Pierik Mj, Alain Bitton, Guhan Venkataraman, Rinse K. Weersma, Schiff Er, Manuel A. Rivas, Harry Ostrer, Bokemeyer B, Judy H. Cho, Sandra May, Michel Georges, Isabelle Cleynen, Moran Cj, Laudes M, Beaugerie L, Laura Fachal, Nir Barzilai, Mikko Hiltunen, Somineni H, Stephan R. Targan, Skeiceviciene J, Kelsen J, Sartor Br, Christopher A. Lamb, Philippe Goyette, Steven R. Brant, Souad Rahmouni, Mark J. Daly, Sheikh Sz, Edouard Louis, Jalas C, Carl A. Anderson, Severine Vermeire, and Aleksejs Sazonovs

Subjects
Genetics, 0303 health sciences, education.field_of_study, Population, Susceptibility gene, Genome-wide association study, Disease, Biology, 3. Good health, 03 medical and health sciences, Disease susceptibility, 0302 clinical medicine, Disease risk, education, Gene, 030217 neurology & neurosurgery, 030304 developmental biology, Genetic association
Abstract

Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD), however, as with all complex diseases, deriving pathogenic mechanisms from these non-coding GWAS discoveries has been challenging. To complement GWAS and better define actionable biological targets, we analysed sequenced data from more than 30,000 CD patients and 80,000 population controls. We observe rare coding variants in established CD susceptibility genes as well as ten genes where coding variation directly implicates the gene in disease risk for the first time.

Published
2021

13. Nodular regenerative hyperplasia in patients with inflammatory bowel disease treated with azathioprine

Author

Vernier-Massouille, G., Cosnes, J., Lemann, M., Marteau, P., Reinisch, W., Laharie, D., Cadiot, G., Bouhnik, Y., De Vos, M., Boureille, A., Duclos, B., Seksik, P., Mary, J.-Y., and Colombel, J.-F.

Subjects
Inflammatory bowel diseases -- Care and treatment, Inflammatory bowel diseases -- Complications and side effects, Azathioprine -- Dosage and administration, Azathioprine -- Complications and side effects, Azathioprine -- Research, Hyperplasia -- Development and progression, Hyperplasia -- Research, Health
Published
2007

14. Impact of the increasing use of immunesuppressants in crohn's disease on the need for intestinal surgery

Author

Cosnes, J, Nion-Larmurier, I, Beaugerie, L, Afchain, P, Tiret, E, and Gendre, J-P

Subjects
Crohn's disease -- Care and treatment, Crohn's disease -- Drug therapy, Crohn's disease -- Research, Mesalamine -- Dosage and administration, Mesalamine -- Research, Mesalamine -- Statistics, Mesalamine -- Analysis, Immunosuppression -- Care and treatment, Immunosuppression -- Research, Immunosuppression -- Statistics, Immunosuppression -- Analysis, Health
Published
2005

15. Reversal of abnormal collagen production in Crohn's disease intestinal biopsies treated with regenerating agents

Author

Alexakis, C., Caruelle, J.P., Sezeur, A., Cosnes, J., Gendre, J.P., Mosnier, H., Beaugerie, L., Gallot, D., Malafosse, M., Barritault, D., and Kern, P.

Subjects
Health
Abstract

Gut 2004;53:85-90 Background: Crohn's disease (CD) is characterised by inflammation, muscle layer overgrowth, and collagenous fibrosis of the intestinal tract, with no effective therapy against collagen accumulation. Aims: We quantified [...]

Published
2004

16. Effects of appendicectomy on the course of ulcerative colitis. (Inflammation and Inflammatory Bowel Disease)

Author

Cosnes, J., Carbonnel, F., Beaugerie, L., Blain, A., Reijasse, D., and Gendre, J-P

Subjects
Appendectomy -- Health aspects, Ulcerative colitis -- Prognosis -- Patient outcomes, Mortality, Health
Abstract

Background: Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. Aim: To determine whether appendicectomy reduces the overall severity [...]

Published
2002

35. Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or infliximab.

Author

UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Laharie, D, Bourreille, A, Branche, J, Allez, M, Bouhnik, Y, Filippi, J, Zerbib, F, Savoye, G, Vuitton, L, Moreau, J, Amiot, A, Cosnes, J, Ricart, E, Dewit, Olivier, Lopez-Sanroman, A, Fumery, M, Carbonnel, F, Bommelaer, G, Coffin, B, Roblin, X, van Assche, G, Esteve, M, Farkkila, M, Gisbert, J P, Marteau, P, Nahon, S, de Vos, M, Lambert, J, Mary, J Y, Louis, E, Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives, UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie, UCL - (SLuc) Service de gastro-entérologie, Laharie, D, Bourreille, A, Branche, J, Allez, M, Bouhnik, Y, Filippi, J, Zerbib, F, Savoye, G, Vuitton, L, Moreau, J, Amiot, A, Cosnes, J, Ricart, E, Dewit, Olivier, Lopez-Sanroman, A, Fumery, M, Carbonnel, F, Bommelaer, G, Coffin, B, Roblin, X, van Assche, G, Esteve, M, Farkkila, M, Gisbert, J P, Marteau, P, Nahon, S, de Vos, M, Lambert, J, Mary, J Y, Louis, E, and Groupe d'Etudes Thérapeutiques des Affections Inflammatoires Digestives

Abstract

OBJECTIVE: Ciclosporin and infliximab have demonstrated short-term similar efficacy as second-line therapies in patients with acute severe UC (ASUC) refractory to intravenous steroids. The aim of this study was to assess long-term outcome of patients included in a randomised trial comparing ciclosporin and infliximab. DESIGN: Between 2007 and 2010, 115 patients with steroid-refractory ASUC were randomised in 29 European centres to receive ciclosporin or infliximab in association with azathioprine. Patients were followed until death or last news up to January 2015. Colectomy-free survival rates at 1 and 5 years and changes in therapy were estimated through Kaplan-Meier method and compared between initial treatment groups through log-rank test. RESULTS: After a median follow-up of 5.4 years, colectomy-free survival rates (95% CI) at 1 and 5 years were, respectively, 70.9% (59.2% to 82.6%) and 61.5% (48.7% to 74.2%) in patients who received ciclosporin and 69.1% (56.9% to 81.3%) and 65.1% (52.4% to 77.8%) in those who received infliximab (p=0.97). Cumulative incidence of first infliximab use at 1 and 5 years in patients initially treated with ciclosporin was, respectively, 45.7% (32.6% to 57.9%) and 57.1% (43.0% to 69.0%). Only four patients from the infliximab group were subsequently switched to ciclosporin. Three patients died during the follow-up, none directly related to UC or its treatment. CONCLUSIONS: In this cohort of patients with steroid-refractory ASUC initially treated by ciclosporin or infliximab, long-term colectomy-free survival was independent from initial treatment. These long-term results further confirm a similar efficacy and good safety profiles of both drugs and do not favour one drug over the other. TRIAL REGISTRATION NUMBER: EudraCT: 2006-005299-42; ClinicalTrials.gouv number: NCT00542152; post-results.

Published
2018

36. Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

Author

Williams, SM, Rivas, MA, Avila, BE, Koskela, J, Huang, H, Stevens, C, Pirinen, M, Haritunians, T, Neale, BM, Kurki, M, Ganna, A, Graham, D, Glaser, B, Peter, I, Atzmon, G, Barzilai, N, Levine, AP, Schiff, E, Pontikos, N, Weisburd, B, Lek, M, Karczewski, KJ, Bloom, J, Minikel, EV, Petersen, B-S, Beaugerie, L, Seksik, P, Cosnes, J, Schreiber, S, Bokemeyer, B, Bethge, J, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Heap, G, Ahmad, T, Plagnol, V, Segal, AW, Targan, S, Turner, D, Saavalainen, P, Farkkila, M, Kontula, K, Palotie, A, Brant, SR, Duerr, RH, Silverberg, MS, Rioux, JD, Weersma, RK, Franke, A, Jostins, L, Anderson, CA, Barrett, JC, MacArthur, DG, Jalas, C, Sokol, H, Xavier, RJ, Pulver, A, Cho, JH, McGovern, DPB, Daly, MJ, Williams, SM, Rivas, MA, Avila, BE, Koskela, J, Huang, H, Stevens, C, Pirinen, M, Haritunians, T, Neale, BM, Kurki, M, Ganna, A, Graham, D, Glaser, B, Peter, I, Atzmon, G, Barzilai, N, Levine, AP, Schiff, E, Pontikos, N, Weisburd, B, Lek, M, Karczewski, KJ, Bloom, J, Minikel, EV, Petersen, B-S, Beaugerie, L, Seksik, P, Cosnes, J, Schreiber, S, Bokemeyer, B, Bethge, J, International IBD Genetics Consortium, NIDDK IBD Genetics Consortium, T2D-GENES Consortium, Heap, G, Ahmad, T, Plagnol, V, Segal, AW, Targan, S, Turner, D, Saavalainen, P, Farkkila, M, Kontula, K, Palotie, A, Brant, SR, Duerr, RH, Silverberg, MS, Rioux, JD, Weersma, RK, Franke, A, Jostins, L, Anderson, CA, Barrett, JC, MacArthur, DG, Jalas, C, Sokol, H, Xavier, RJ, Pulver, A, Cho, JH, McGovern, DPB, and Daly, MJ

Abstract

As part of a broader collaborative network of exome sequencing studies, we developed a jointly called data set of 5,685 Ashkenazi Jewish exomes. We make publicly available a resource of site and allele frequencies, which should serve as a reference for medical genetics in the Ashkenazim (hosted in part at https://ibd.broadinstitute.org, also available in gnomAD at http://gnomad.broadinstitute.org). We estimate that 34% of protein-coding alleles present in the Ashkenazi Jewish population at frequencies greater than 0.2% are significantly more frequent (mean 15-fold) than their maximum frequency observed in other reference populations. Arising via a well-described founder effect approximately 30 generations ago, this catalog of enriched alleles can contribute to differences in genetic risk and overall prevalence of diseases between populations. As validation we document 148 AJ enriched protein-altering alleles that overlap with "pathogenic" ClinVar alleles (table available at https://github.com/macarthur-lab/clinvar/blob/master/output/clinvar.tsv), including those that account for 10-100 fold differences in prevalence between AJ and non-AJ populations of some rare diseases, especially recessive conditions, including Gaucher disease (GBA, p.Asn409Ser, 8-fold enrichment); Canavan disease (ASPA, p.Glu285Ala, 12-fold enrichment); and Tay-Sachs disease (HEXA, c.1421+1G>C, 27-fold enrichment; p.Tyr427IlefsTer5, 12-fold enrichment). We next sought to use this catalog, of well-established relevance to Mendelian disease, to explore Crohn's disease, a common disease with an estimated two to four-fold excess prevalence in AJ. We specifically attempt to evaluate whether strong acting rare alleles, particularly protein-truncating or otherwise large effect-size alleles, enriched by the same founder-effect, contribute excess genetic risk to Crohn's disease in AJ, and find that ten rare genetic risk factors in NOD2 and LRRK2 are enriched in AJ (p < 0.005), including several novel con

Published
2018

40. A negative screening does not eliminate tuberculosis risk under anti-TNF treatment in inflammatory bowel disease: a descriptive study

Author

Abitbol, Y., Laharie, D., Cosnes, J., Allez, M., Nancey, S., Amiot, Audrey, Aubourg, A., Fumery, Mathurin, Altwegg, R., Michetti, P., Chanteloup, E., Seksik, P., Abitbol, V., Baudry, C., Flamant, M., Bouguen, G., Stefanescu, C., Bourrier, A., Bommelaer, G., Dib, N., Bigard, M. A., Viennot, S., Hébuterne, X., Gornet, J. M., Marteau, P., Bouhnik, Y., Nahon, S, Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d’hépatogastroenterologie, CHU Amiens-Picardie, Département de gastroentérologie, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Foie, métabolismes et cancer, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Service de gastroentérologie, MICI et assistance nutritive, pôle des maladies de l’appareil digestif, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Universitaire de Nice (CHU de Nice), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), AP-HP, Hôpital Lariboisière, Hôpital Lariboisière-Fernand-Widal [APHP], CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Nice (CHU Nice), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
[SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Meeting abstract Sa1949

Published
2016

41. Long-term follow-up after ileorectal anastomosis in ulcerative colitis (UC) identified factors associated with rectal outcome: a multicentre retrospective cohort of 343 patients from the GETAID/GETAID Surgery

Author

Uzzan, M., Cosnes, J., Oubaya, N., Amiot, A., Gault, N., Gornet, J-M, Seksik, P., Nancey, S., Cotte, E., Allez, M., Laharie, D., De Angelis, N., Nachury, M., Pelletier, A-L, Abitbol, V., Fumery, Mathurin, Brouquet, A., Buisson, A., Altwegg, R., Panis, Y., Treton, X., Service de Gastroentérologie [Hôpital Beaujon], Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Henri Mondor [Créteil], Unité d'Epidémiologie et Recherche Clinique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Hopital Saint-Louis [AP-HP] (AP-HP), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Département de gastroentérologie, Hôpital Cochin [AP-HP], CHU Amiens-Picardie, Périnatalité et Risques Toxiques - UMR INERIS_I 1 (PERITOX), Institut National de l'Environnement Industriel et des Risques (INERIS)-Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Gastroentérologie et nutrition [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Henri Mondor, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-IFR10, Département de Radiobiologie et Radiopathologie (CEA/DSV/DRR), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Microorganismes, Molécules Bioactives et Physiopathologie Intestinale (LBM-E4), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Claude Huriez [Lille], CHU Lille, Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie-Institut National de l'Environnement Industriel et des Risques, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), Institut National de la Recherche Agronomique (INRA)-Université d'Auvergne - Clermont-Ferrand I (UdA), Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), and LabEx Inflamex

Subjects
[SDV]Life Sciences [q-bio], education, social sciences, ComputingMilieux_MISCELLANEOUS, geographic locations, digestive system diseases, health care economics and organizations
Abstract

s of the 11th Congress of ECCO - European Crohn’s and Colitis Organisation; International audience

Published
2016

42. Long-term outcome of patients with steroid-refractory acute severe UC treated with ciclosporin or infliximab

Author

Laharie, D, primary, Bourreille, A, additional, Branche, J, additional, Allez, M, additional, Bouhnik, Y, additional, Filippi, J, additional, Zerbib, F, additional, Savoye, G, additional, Vuitton, L, additional, Moreau, J, additional, Amiot, A, additional, Cosnes, J, additional, Ricart, E, additional, Dewit, O, additional, Lopez-Sanroman, A, additional, Fumery, M, additional, Carbonnel, F, additional, Bommelaer, G, additional, Coffin, B, additional, Roblin, X, additional, van Assche, G, additional, Esteve, M, additional, Farkkila, M, additional, Gisbert, JP, additional, Marteau, P, additional, Nahon, S, additional, de Vos, M, additional, Lambert, J, additional, Mary, JY, additional, and Louis, E, additional

Published
2017
Full Text
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44. Sarcoïdoses avec atteinte du tube digestif

Author

Ghrenassia, E., primary, Mekinian, A., additional, Chapelon-Abric, C., additional, Cosnes, J., additional, Lefevre, G., additional, Morell-Dubois, S., additional, Prendki, V., additional, Sève, P., additional, Dhôte, R., additional, Launay, D., additional, Valeyre, D., additional, and Fain, O., additional

Published
2015
Full Text
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45. Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health

Author

Peyrin Biroulet, L., Cieza, A., Sandborn, W.J., Coenen, M., Chowers, Y., Hibi, T., Kostanjsek, N., Stucki, G., Colombel, J.F., Reinisch, W., Tilg, H., Kamm, M., D'Haens, G., Louis, E., Van Assche, G., Feagan, B., Irvine, E.J., Michetti, P., Schölmerich, J., Schreiber, S., Munkholm, P., Panes, J., Cosnes, J., Lémann, M., Lewin, M., Mary, J.Y., Pariente, B., Travis, S., Danese, S., Vecchi, M., Hommes, D.W., Oresland, T., Fletcher, J., Loftus, J.E.V., and Sands, B.E.

Subjects
Settore MED/12 - Gastroenterologia
Published
2012

46. [Complications of celiac disease]

Author

Cosnes, J., Nion-Larmurier, I., and Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Celiac Disease, Diet, Gluten-Free, Lymphoma, Survival, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Neoplasms, nutritional and metabolic diseases, Humans, Prognosis, digestive system diseases
Abstract

International audience; Numerous complications can occur in celiac disease, nutritional (growth failure in children, malnutrition, vitamin deficiencies), hematologic (anaemia), bone disease (osteoporosis, fracture), gynaecologic (hypo fertility), cardiovascular (coronaropathy, venous thrombosis), neurological (peripheral neuropathy), hepatic (cytolysis, cirrhosis). Celiac disease is associated with an increased risk of autoimmune diseases (type 1 diabetes, thyroiditis), and cancer (upper digestive tract, hepatocellular carcinoma, lymphoma). The main digestive complications are microscopic colitis and refractory sprue, which are resistant to gluten-free diet. It can be associated with a monoclonal proliferation of intraepithelial lymphocytes (type 2 refractory sprue), which may be considered as a cryptic lymphoma and can lead to invasive T lymphoma, which occurs in one celiac patient in 1000. Gluten-free diet protects from the occurrence of most complications and correct the over-mortality related to these complications.

Published
2011

48. Presentation and long term follow-up of refractory celiac disease : comparison of type I with type II

Author

Lecomte , Philippe, Malamut , Georgia, Afchain , P., Verkarre , V., Amiot , Audrey, Damotte , D., Bouhnik , Yoram, Colombel , J.F., Delchier , Jean-Charles, Allez , M., Cosnes , J., Lavergne-Slove , A., Macintyre , Elizabeth A, Meresse , Bertrand, Radford-Weiss , Isabelle, Trinquart , L., Hermine , O., Brousse , N., Cerf-Bensussan , Nadine, Cellier , C., Génétique, immunothérapie, chimie et cancer (GICC), UMR 6239 CNRS [2008-2011] (GICC UMR 6239 CNRS), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Service d'hépato-gastro-entérologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service de gastro-entérologie et assistance nutritive, Hôpital Beaujon-Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Service d'hépato-gastro-entérologie [APHP Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), University of Chicago, Laboratoire de Cytogénétique, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Cytokines, hématopoïèse et réponse immune (CHRI), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pathologie et virologie moléculaire (PVM), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Service d'anatomie pathologique [CHU Necker], Interactions de l'épithélium intestinal avec les sytème immunitaire et les antigènes intraluminaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Interactions de l'épithelium intestinal avec le système immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Pathologie et virologie moléculaire (PVM (UMR_7151)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Dequeant, Evelyne, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Hôpital Henri Mondor-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Génétique, Immunothérapie, Chimie et Cancer ( GICC ), Université de Tours-Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 ( UPEC UP12 ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -CHU Necker - Enfants Malades [AP-HP], Cytokines, hématopoïèse et réponse immune ( CHRI ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Pathologie et virologie moléculaire ( PVM ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Institut National de la Santé et de la Recherche Médicale ( INSERM ), and Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM )

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2009

49. Risk factors associated with small bowel adenocarcinoma in Crohn's disease: a case-control study

Author

Piton, G., Cosnes, J., Monnet, E., Beaugerie, L., Seksik, P., Savoye, Guillaume, Cadiot, G., Flourie, B., Capelle, P., Marteau, P., Lemann, M., Colombel, Jf., Khouri, E., Bonaz, B., Carbonnel, F., Agents pathogènes et inflammation - UFC (EA 4266) (API), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service d'Hépato-Gastroentérologie [CHU Rouen], Hôpital Charles Nicolle [Rouen]-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

50. [Cutaneous manifestations associated with chronic inflammatory bowel disease]

Author

Farhi, D., Cosnes, J., Aractingi, S., Khosrotehrani, K., and Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Diagnosis, Differential, Crohn Disease, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Humans, Inflammatory Bowel Diseases, Skin Diseases, ComputingMilieux_MISCELLANEOUS, Pyoderma Gangrenosum
Abstract

International audience

Published
2008

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