1. Particularities of the intestinal microbiome composition in Romanian patients with metabolic syndrome and type 2 diabetes
- Author
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Raluca A. CORB ARON, Delia M. TIT, Radu MOLERIU, Cosmin M. VESA, Sergiu BUNGAU, Alexandra G. TARCE, Tapan BEHL, and Simona G. BUNGAU
- Subjects
metabolic syndrome ,type 2 diabetes ,weight status ,glucidic profile ,lipidic profile ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction. The composition of gut microbiota can be affected by type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), its improvement is frequently ignored in metabolic disorders. The objective of the study was a comparative evaluation of the faecal microbiota of healthy controls and of T2DM and MS patients (n = 150). Materials and methods. A retrospective cross-sectional study was performed, between July 2019-December 2020 in the Bio-standard laboratory Oradea, Romania. A group of 75 patients with non-insulin dependent T2DM and MS (study group = SG) and 75 healthy subjects (control group = CG) has been included in the study. The composition of the microbiome and the influence of oral antidiabetic treatment on the microbiome in SG patients were compared. Results. 8 out of 19 species of the analysed bacteria had a different relative abundance in the SG, compared to CG; Enterococcus spp. were significantly higher (3.18×106 vs 1.94×106, p=0.004), while Akkermansia muciniphila (2.55×109 vs. 4.66×109, p
- Published
- 2021
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