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1. Disseminated nocardiosis and anti-GM-CSF antibodies

Author

Brugnoli, Barbara, Salvati, Lorenzo, Di Lauria, Nicoletta, Botta, Annarita, Tozzetti, Camilla, Biscarini, Alessandro, Capone, Manuela, Ferrentino, Filomena, Naldi, Chiara, Ascione, Giovanni, Mazzoni, Alessio, Maggi, Laura, Campo, Ilaria, Carey, Brenna, Trapnell, Bruce, Liotta, Francesco, Cosmi, Lorenzo, Bartoloni, Alessandro, Annunziato, Francesco, Parronchi, Paola, and Palterer, Boaz

Published
2024
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2. Effect of antimetabolite regimen on cellular and humoral immune response to SARS-COV-2 vaccination in solid organ transplant recipients

Author

Capone, Manuela, Vanni, Anna, Salvati, Lorenzo, Lamacchia, Giulia, Mazzoni, Alessio, Maggi, Laura, Cosmi, Lorenzo, Liotta, Francesco, Romagnani, Paola, Cirillo, Luigi, Buti, Elisa, Terlizzi, Vito, Azzari, Chiara, Citera, Francesco, Barbati, Federica, Rossolini, Gian Maria, Bresci, Silvia, Borchi, Beatrice, Cavallo, Annalisa, Mencarini, Jessica, Francalanci, Emanuela, Kiros, Seble Tekle, Bartoloni, Alessandro, and Annunziato, Francesco

Published
2024
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4. Severe Asthma Network Italy Definition of Clinical Remission in Severe Asthma: A Delphi Consensus

Author

Canonica, Giorgio Walter, Blasi, Francesco, Carpagnano, Giovanna Elisiana, Guida, Giuseppe, Heffler, Enrico, Paggiaro, Pierluigi, Allegrini, Chiara, Antonelli, Andrea, Aruanno, Arianna, Bacci, Elena, Bagnasco, Diego, Beghè, Bianca, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Caiaffa, Maria Filomena, Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Caruso, Cristiano, Cavallini, Mirta, Chieco Bianchi, Fulvia, Conte, Maria Elisabetta, Corsico, Angelo Guido, Cosmi, Lorenzo, Costantino, Mariateresa, Costanzo, Giulia, Crivellaro, Mariaangiola, D'Alò, Simona, D'Amato, Mariella, Detoraki, Aikaterini, Di Proietto, Maria Carmela, Facciolongo, Nicola Cosimo, Ferri, Sebastian, Fierro, Vincenzo, Foschino, Maria Pia, Latorre, Manuela, Lombardi, Carlo, Macchia, Luigi, Milanese, Manlio, Montagni, Marcello, Parazzini, Elena Maria, Parente, Roberta, Passalacqua, Giovanni, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ridolo, Erminia, Rolo, Joyce, Scichilone, Nicola, Scioscia, Giulia, Senna, Gianenrico, Solidoro, Paolo, Varricchi, Gilda, Vianello, Andrea, Yacoub, Mona Rita, and Yang, Baoran

Published
2023
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6. Clinical and Immunological Features of SARS-CoV-2 Breakthrough Infections in Vaccinated Individuals Requiring Hospitalization

Author

Lamacchia, Giulia, Mazzoni, Alessio, Spinicci, Michele, Vanni, Anna, Salvati, Lorenzo, Peruzzi, Benedetta, Bencini, Sara, Capone, Manuela, Carnasciali, Alberto, Farahvachi, Parham, Rocca, Arianna, Kiros, Seble Tekle, Graziani, Lucia, Zammarchi, Lorenzo, Mencarini, Jessica, Colao, Maria Grazia, Caporale, Roberto, Liotta, Francesco, Cosmi, Lorenzo, Rossolini, Gian Maria, Bartoloni, Alessandro, Maggi, Laura, and Annunziato, Francesco

Published
2022
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7. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Author

Cossarizza, Andrea, Chang, Hyun-Dong, Radbruch, Andreas, Acs, Andreas, Adam, Dieter, Adam-Klages, Sabine, Agace, William W, Aghaeepour, Nima, Akdis, Mübeccel, Allez, Matthieu, Almeida, Larissa Nogueira, Alvisi, Giorgia, Anderson, Graham, Andrä, Immanuel, Annunziato, Francesco, Anselmo, Achille, Bacher, Petra, Baldari, Cosima T, Bari, Sudipto, Barnaba, Vincenzo, Barros-Martins, Joana, Battistini, Luca, Bauer, Wolfgang, Baumgart, Sabine, Baumgarth, Nicole, Baumjohann, Dirk, Baying, Bianka, Bebawy, Mary, Becher, Burkhard, Beisker, Wolfgang, Benes, Vladimir, Beyaert, Rudi, Blanco, Alfonso, Boardman, Dominic A, Bogdan, Christian, Borger, Jessica G, Borsellino, Giovanna, Boulais, Philip E, Bradford, Jolene A, Brenner, Dirk, Brinkman, Ryan R, Brooks, Anna ES, Busch, Dirk H, Büscher, Martin, Bushnell, Timothy P, Calzetti, Federica, Cameron, Garth, Cammarata, Ilenia, Cao, Xuetao, Cardell, Susanna L, Casola, Stefano, Cassatella, Marco A, Cavani, Andrea, Celada, Antonio, Chatenoud, Lucienne, Chattopadhyay, Pratip K, Chow, Sue, Christakou, Eleni, Čičin-Šain, Luka, Clerici, Mario, Colombo, Federico S, Cook, Laura, Cooke, Anne, Cooper, Andrea M, Corbett, Alexandra J, Cosma, Antonio, Cosmi, Lorenzo, Coulie, Pierre G, Cumano, Ana, Cvetkovic, Ljiljana, Dang, Van Duc, Dang-Heine, Chantip, Davey, Martin S, Davies, Derek, De Biasi, Sara, Del Zotto, Genny, Dela Cruz, Gelo Victoriano, Delacher, Michael, Della Bella, Silvia, Dellabona, Paolo, Deniz, Günnur, Dessing, Mark, Di Santo, James P, Diefenbach, Andreas, Dieli, Francesco, Dolf, Andreas, Dörner, Thomas, Dress, Regine J, Dudziak, Diana, Dustin, Michael, Dutertre, Charles-Antoine, Ebner, Friederike, Eckle, Sidonia BG, Edinger, Matthias, Eede, Pascale, Ehrhardt, Götz RA, Eich, Marcus, Engel, Pablo, Engelhardt, Britta, and Erdei, Anna

Subjects
1.1 Normal biological development and functioning, Underpinning research, Inflammatory and immune system, Allergy and Immunology, Cell Separation, Consensus, Flow Cytometry, Humans, Phenotype, Immunology
Abstract

These guidelines are a consensus work of a considerable number of members of the immunology and flow cytometry community. They provide the theory and key practical aspects of flow cytometry enabling immunologists to avoid the common errors that often undermine immunological data. Notably, there are comprehensive sections of all major immune cell types with helpful Tables detailing phenotypes in murine and human cells. The latest flow cytometry techniques and applications are also described, featuring examples of the data that can be generated and, importantly, how the data can be analysed. Furthermore, there are sections detailing tips, tricks and pitfalls to avoid, all written and peer-reviewed by leading experts in the field, making this an essential research companion.

Published
2019

8. Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life

Author

Nettis, Eustachio, Brussino, Luisa, Patella, Vincenzo, Bonzano, Laura, Detoraki, Aikaterini, Di Leo, Elisabetta, Sirufo, Maria Maddalena, Caruso, Cristiano, Lodi Rizzini, Fabio, Conte, Mariaelisabetta, Yacoub, Mona-Rita, Triggiani, Massimo, Ridolo, Erminia, Macchia, Luigi, Rolla, Giovanni, Brancaccio, Raffaele, De Paulis, Amato, Spadaro, Giuseppe, Di Bona, Danilo, D’Uggento, Angela Maria, Ginaldi, Lia, Gaeta, Francesco, Nucera, Eleonora, Jaubashi, Kliljeda, Villalta, Danilo, Dagna, Lorenzo, Ciotta, Domenico, Pucciarini, Francesco, Bagnasco, Diego, Celi, Giorgio, Chieco Bianchi, Fulvia, Cosmi, Lorenzo, Costantino, Maria Teresa, Crivellaro, Maria Angiola, D’Alò, Simona, del Biondo, Pietro, Del Giacco, Stefano, Di Gioacchino, Mario, Di Pietro, Linda, Favero, Elisabetta, Gangemi, Sebastiano, Guarnieri, Gabriella, Heffler, Enrico, Leto Barone, Maria Stefania, Lombardo, Carla, Losa, Francesca, Matucci, Andrea, Minciullo, Paola Lucia, Parronchi, Paola, Passalacqua, Giovanni, Pucci, Stefano, Rossi, Oliviero, Salvati, Lorenzo, Schiappoli, Michele, Senna, Gianenrico, Vianello, Andrea, Vultaggio, Alessandra, Baoran, Yang, Incorvaia, Cristoforo, and Canonica, Giorgio Walter

Published
2022
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9. Primary Immunodeficiencies

Author

Cosmi, Lorenzo, Palterer, Boaz, Annunziato, Francesco, Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima Tatiana, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, Vaglio, Augusto, Editorial Board Member, and Annunziato, Francesco, editor

Published
2021
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10. Lung in Cellular Immunodeficiencies

Author

Vivarelli, Emanuele, Cosmi, Lorenzo, Emmi, Lorenzo, Series Editor, Prisco, Domenico, Series Editor, Salvarani, Carlo, Editorial Board Member, Sinico, Renato Alberto, Editorial Board Member, Meroni, Pier Luigi, Editorial Board Member, Roccatello, Dario, Editorial Board Member, Matucci-Cerinic, Marco, Editorial Board Member, Gattorno, Marco, Editorial Board Member, de Benedetti, Fabrizio, Editorial Board Member, Cimaz, Rolando, Editorial Board Member, Plebani, Alessandro, Editorial Board Member, Baldari, Cosima Tatiana, Editorial Board Member, D'Elios, Mario Milco, Editorial Board Member, Vaglio, Augusto, Editorial Board Member, and Annunziato, Francesco, editor

Published
2021
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11. Management of patients with chronic rhinosinusitis with nasal polyps (CRSwNP): Results from a survey among allergists and clinical immunologists of the North-west and Center Italy Inter-Regional Sections of SIAAIC and otorhinolaryngologists of National IAR

Author

Bagnasco, Diego, primary, Brussino, Luisa, additional, Biagini, Cesare, additional, Cosmi, Lorenzo, additional, De Corso, Eugenio, additional, La Mantia, Ignazio, additional, Macchi, Alberto, additional, Maggiore, Giandomenico, additional, Matucci, Andrea, additional, Nicola, Stefania, additional, Passalacqua, Giovanni, additional, Presutti, Livio, additional, Seccia, Veronica, additional, Vultaggio, Alessandra, additional, Riparbelli, Michele, additional, Sartor, Chiara, additional, Parronchi, Paola, additional, and Canevari, Frank Rikki Mauritz, additional

Published
2024
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12. Severe asthma: One disease and multiple definitions

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Giovanna Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Lombardi, Carlo, Spadaro, Giuseppe, Detoraki, Caterina, Menzella, Francesco, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, D’Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D’Amato, Verrillo, Maria Vittoria, Rolla, Giovanni, Brussino, Luisa, Frazzetto, Agata Valentina, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Senna, Gianenrico, Caminati, Marco, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D’Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Paggiaro, Pierluigi, Latorre, Manuela, Folli, Chiara, Testino, Elisa, Bassi, Arianna, Milanese, Manlio, Heffler, Enrico, Manfredi, Andrea, Riccio, Anna Maria, De Ferrari, Laura, Blasi, Francesco, Canevari, Rikki Frank, Canonica, Giorgio Walter, and Passalacqua, Giovanni

Published
2021
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13. Economic impact of mepolizumab in uncontrolled severe eosinophilic asthma, in real life

Author

Guarnieri, Gabriella, Patella, Vincenzo, Maria Pia, Foschino Barbaro, Carpagnano, Elisiana, Colle, Anna del, Scioscia, Giulia, Gerolamo, Pelaia, Paggiaro, Pierluigi, Latorre, Manuela, Puggioni, Francesca, Racca, Francesca, Favero, Elisabetta, Iannacone, Sandra, Savi, Eleonora, Montagni, Marcello, Camiciottoli, Gianna, Allegrini, Chiara, Spadaro, Giuseppe, Detoraki, Caterina, Galeone, Carla, Ruggiero, Patrizia, Yacoub, Monna Rita, Berti, Alvise, Colombo, Gisella, Scichilone, Nicola, Durante, Carmen, Costantino, Maria Teresa, Roncallo, Chiara, Braschi, Mariachiara, Blasi, Francesco, D'Adda, Alice, Ridolo, Erminia, Triggiani, Massimo, Parente, Roberta, Maria, D'Amato, Verrillo, Maria Vittoria, Cristina, Zappa Maria, Lilli, Marianna, Crimi, Nunzio, Bonavia, Marco, Corsico, Angelo Guido, Grosso, Amelia, Del Giacco, Stefano, Deidda, Margherita, Ricciardi, Luisa, Isola, Stefania, Cicero, Francesca, Amato, Giuliana, Vita, Federica, Spanevello, Antonio, Pignatti, Patrizia, Cherubino, Francesca, Visca, Dina, Aletti, Eleonora, Massimo Ricciardolo, Fabio Luigi, Anna Carriero, Vitina Maria, Bertolini, Francesca, Santus, Pierachille, Barlassina, Roberta, Airoldi, Andrea, Guida, Giuseppe, Eleonora, Nucera, Aruanno, Arianna, Rizzi, Angela, Caruso, Cristiano, Colantuono, Stefania, Arcolaci, Alessandra, Vianello, Andrea, Bianchi, Fulvia Chieco, Marchi, Maria Rita, Centanni, Stefano, Luraschi, Simone, Ruggeri, Silvia, Rinaldo, Rocco, Parazzini, Elena, Calabrese, Cecilia, Flora, Martina, Cosmi, Lorenzo, Di Pietro, Linda, Maggi, Enrico, Pini, Laura, Macchia, Luigi, Di Bona, Danilo, Richeldi, Luca, Condoluci, Carola, Fuso, Leonello, Bonini, Matteo, Farsi, Alessandro, Carli, Giulia, Montuschi, Paolo, Santini, Giuseppe, Conte, Maria Elisabetta, Turchet, Elisa, Barbetta, Carlo, Mazza, Francesco, D'Alo, Simona, Pucci, Stefano, Caiaffa, Maria Filomena, Minenna, Elena, D'Elia, Luciana, Pasculli, Carlo, Viviano, Vittorio, Tarsia, Paolo, Rolo, Joyce, Di Proietto, Mariacarmela, Lo Cicero, Salvatore, Bagnasco, Diego, Povero, Massimiliano, Pradelli, Lorenzo, Brussino, Luisa, Rolla, Giovanni, Caminati, Marco, Menzella, Francesco, Heffler, Enrico, Canonica, Giorgio Walter, Senna, Gianenrico, Milanese, Manlio, Lombardi, Carlo, Bucca, Caterina, Manfredi, Andrea, Canevari, Rikki Frank, and Passalacqua, Giovanni

Published
2021
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14. Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC).

Author

Caminati, Marco, Brussino, Luisa, Carlucci, Matilde, Carlucci, Palma, Carpagnano, Lucia Federica, Caruso, Cristiano, Cosmi, Lorenzo, D'Amore, Simona, Del Giacco, Stefano, Detoraki, Aikaterini, Di Gioacchino, Mario, Matucci, Andrea, Mormile, Ilaria, Granata, Francescopaolo, Guarnieri, Gabriella, Krampera, Mauro, Maule, Matteo, Nettis, Eustachio, Nicola, Stefania, and Noviello, Silvia

Subjects
HYPEREOSINOPHILIC syndrome, DELAYED diagnosis, THERAPEUTICS, CLINICAL immunology, PHYSICIANS
Abstract

Hypereosinophilic syndrome (HES) encompasses a heterogeneous and complex group of different subtypes within the wider group of hypereosinophilic disorders. Despite increasing research interest, several unmet needs in terms of disease identification, pathobiology, phenotyping, and personalized treatment remain to be addressed. Also, the prospective burden of non-malignant HES and, more in general, HE disorders is currently unknown. On a practical note, shortening the diagnostic delay and the time to an appropriate treatment approach probably represents the most urgent issue, even in light of the great impact of HES on the quality of life of affected patients. The present document represents the first action that the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC) has finalized within a wider project aiming to establish a collaborative national network on HES (InHES—Italian Network on HES) for patients and physicians. The first step of the project could not but focus on defining a common language as well as sharing with all of the medical community an update on the most recent advances in the field. In fact, the existing literature has been carefully reviewed in order to critically integrate the different views on the topic and derive practical recommendations on disease identification and treatment approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

Author

Canonica, Giorgio Walter, Blasi, Francesco, Paggiaro, Pierluigi, Senna, Gianenrico, Passalacqua, Giovanni, Spanevello, Antonio, Aliberti, Stefano, Bagnasco, Diego, Bonavia, Marco, Bonini, Matteo, Brussino, Luisa, Bucca, Caterina, Caiaffa, Maria F., Calabrese, Cecilia, Camiciottoli, Gianna, Caminati, Marco, Carpagnano, Giovanna E., Caruso, Cristiano, Centanni, Stefano, Conte, Maria E., Corsico, Angelo G., Cosmi, Lorenzo, Costantino, Maria T., Crimi, Nunzio, D’Alò, Simona, D'Amato, Maria, Del Giacco, Stefano, Farsi, Alessandro, Favero, Elisabetta, Foschino Barbaro, Maria P., Guarnieri, Gabriella, Guida, Giuseppe, Latorre, Manuela, Lo Cicero, Salvatore, Lombardi, Carlo, Macchia, Luigi, Mazza, Francesco, Menzella, Francesco, Milanese, Manlio, Montagni, Marcello, Montuschi, Paolo, Nucera, Eleonora, Parente, Roberta, Patella, Vincenzo, Pelaia, Girolamo, Pini, Laura, Puggioni, Francesca, Ricciardi, Luisa, Ricciardolo, Fabio L.M., Richeldi, Luca, Ridolo, Erminia, Rolla, Giovanni, Santus, Pierachille, Scichilone, Nicola, Spadaro, Giuseppe, Vianello, Andrea, Viviano, Vittorio, Yacoub, Mona R., Zappa, Maria C., and Heffler, Enrico

Published
2020
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16. Prompt Predicting of Early Clinical Deterioration of Moderate-to-Severe COVID-19 Patients: Usefulness of a Combined Score Using IL-6 in a Preliminary Study

Author

Vultaggio, Alessandra, Vivarelli, Emanuele, Virgili, Gianni, Lucenteforte, Ersilia, Bartoloni, Alessandro, Nozzoli, Carlo, Morettini, Alessandro, Berni, Andrea, Malandrino, Danilo, Rossi, Oliviero, Nencini, Francesca, Pieralli, Filippo, Peris, Adriano, Lagi, Filippo, Scocchera, Giulia, Spinicci, Michele, Trotta, Michele, Mazzetti, Marcello, Parronchi, Paola, Cosmi, Lorenzo, Liotta, Francesco, Fontanari, Paolo, Mazzoni, Alessio, Salvati, Lorenzo, Maggi, Enrico, Annunziato, Francesco, Almerigogna, Fabio, and Matucci, Andrea

Published
2020
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17. Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent

Author

Mazzoni, Alessio, Salvati, Lorenzo, Maggi, Laura, Capone, Manuela, Vanni, Anna, Spinicci, Michele, Mencarini, Jessica, Caporale, Roberto, Peruzzi, Benedetta, Antonelli, Alberto, Trotta, Michele, Zammarchi, Lorenzo, Ciani, Luca, Gori, Leonardo, Lazzeri, Chiara, Matucci, Andrea, Vultaggio, Alessandra, Rossi, Oliviero, Almerigogna, Fabio, Parronchi, Paola, Fontanari, Paolo, Lavorini, Federico, Peris, Adriano, Rossolini, Gian Maria, Bartoloni, Alessandro, Romagnani, Sergio, Liotta, Francesco, Annunziato, Francesco, and Cosmi, Lorenzo

Subjects
Lymphocytes -- Health aspects, Antiviral agents -- Evaluation, Coronaviruses -- Health aspects, Communicable diseases -- Development and progression, Disease susceptibility -- Development and progression, Immune response -- Health aspects, COVID-19 -- Development and progression, Adult respiratory distress syndrome -- Development and progression, Health care industry
Abstract

BACKGROUND. Coronavirus disease 19 (COVID-19) is an emerging infectious disease caused by SARS-CoV-2. Antiviral immune response is crucial to achieve pathogen clearance; however, in some patients an excessive and aberrant host immune response can lead to an acute respiratory distress syndrome. The comprehension of the mechanisms that regulate pathogen elimination, immunity, and pathology is essential to better characterize disease progression and widen the spectrum of therapeutic options. METHODS. We performed a flow cytometric characterization of immune cell subsets from 30 patients with COVID-19 and correlated these data with clinical outcomes. RESULTS. Patients with COVID-19 showed decreased numbers of circulating T, B, and NK cells and exhibited a skewing of [CD8.sup.+] T cells toward a terminally differentiated/senescent phenotype. In agreement, [CD4.sup.+] T and [CD8.sup.+] T, but also NK cells, displayed reduced antiviral cytokine production capability. Moreover, a reduced cytotoxic potential was identified in patients with COVID-19, particularly in those who required intensive care. The latter group of patients also showed increased serum IL-6 levels that inversely correlated to the frequency of granzyme A-expressing NK cells. Off-label treatment with tocilizumab restored the cytotoxic potential of NK cells. CONCLUSION. The association between IL-6 serum levels and the impairment of cytotoxic activity suggests the possibility that targeting this cytokine may restore antiviral mechanisms. FUNDING. This study was supported by funds from the Department of Experimental and Clinical Medicine of University of Florence (the ex-60% fund and the 'Excellence Departments 2018-2022 Project') derived from Ministero dell'Istruzione, dell'Universita e della Ricerca (Italy)., Introduction SARS-CoV-2 is the etiological agent of coronavirus disease 19 (COVID-19) and belongs to the same group of RNA viruses that caused SARS and Middle East respiratory syndrome (MERS) in [...]

Published
2020
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21. SARS-CoV-2 infection and vaccination trigger long-lived B and [CD4.sup.+] T lymphocytes with implications for booster strategies

Author

Mazzoni, Alessio, Vanni, Anna, Spinicci, Michele, Lamacchia, Giulia, Kiros, Seble Tekle, Rocca, Arianna, Capone, Manuela, Lauria, Nicoletta Di, Salvati, Lorenzo, Carnasciali, Alberto, Mantengoli, Elisabetta, Farahvachi, Parham, Zammarchi, Lorenzo, Lagi, Filippo, Colao, Maria Grazia, Liotta, Francesco, Cosmi, Lorenzo, Maggi, Laura, Bartoloni, Alessandro, Rossolini, Gian Maria, and Annunziato, Francesco

Subjects
Immunologic memory -- Research, Immunological research, B cells -- Health aspects -- Physiological aspects, CD4 lymphocytes -- Health aspects -- Physiological aspects, Health care industry
Abstract

BACKGROUND. Immunization against SARS-CoV-2, the causative agent of COVID-19, occurs via natural infection or vaccination. However, it is currently unknown how long infection- or vaccination-induced immunological memory will last. METHODS. We performed a longitudinal evaluation of immunological memory to SARS-CoV-2 up to 1 year after infection and following mRNA vaccination in naive individuals and individuals recovered from COVID-19 infection. RESULTS. We found that memory cells are still detectable 8 months after vaccination, while antibody levels decline significantly, especially in naive individuals. We also found that a booster injection is efficacious in reactivating immunological memory to spike protein in naive individuals, whereas it was ineffective in previously SARS-CoV-2-infected individuals. Finally, we observed a similar kinetics of decay of humoral and cellular immunity to SARS-CoV-2 up to 1 year following natural infection in a cohort of unvaccinated individuals. CONCLUSION. Short-term persistence of humoral immunity, together with the reduced neutralization capacity versus the currently prevailing SARS-CoV-2 variants, may account for reinfections and breakthrough infections. Long-lived memory B and CD4* T cells may protect from severe disease development. In naive individuals, a booster dose restored optimal antispike immunity, whereas the needs for vaccinated individuals who have recovered from COVID-19 have yet to be defined. FUNDING. This study was supported by funds to the Department of Experimental and Clinical Medicine, University of Florence (Project Excellence Departments 2018-2022), the University of Florence (project RICTD2122), the Italian Ministry of Health (COVID-2020-12371849), and the region of Tuscany (TagSARS CoV 2)., Introduction Immunization against SARS-CoV-2, the causative agent of COVID-19 occurs via natural infection or vaccination. As of December 20, 2021, more than 273 million people have been infected worldwide, with [...]

Published
2022
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22. Th17 Response

Author

Cosmi, Lorenzo, Liotta, Francesco, Annunziato, Francesco, and Parnham, Michael J., editor

Published
2016
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23. Bendamustine impairs humoral but not cellular immunity to SARS-CoV-2 vaccination in rituximab-treated B-cell lymphoma-affected patients.

Author

Vanni, Anna, Salvati, Lorenzo, Mazzoni, Alessio, Lamacchia, Giulia, Capone, Manuela, Francalanci, Stefania, Kiros, Seble Tekle, Cosmi, Lorenzo, Puccini, Benedetta, Ciceri, Manuel, Sordi, Benedetta, Rossolini, Gian Maria, Annunziato, Francesco, Maggi, Laura, and Liotta, Francesco

Subjects
CELLULAR immunity, IMMUNOLOGIC memory, BOOSTER vaccines, HUMORAL immunity, SARS-CoV-2
Abstract

Background: Patients with B-cell lymphoma are a fragile category of subjects, particularly exposed to infections and characterized by an impaired vaccination response due to the disease itself and, even more, to the chemotherapy regimen. For this reason, extensive knowledge of the immune response status of these subjects is of fundamental importance to obtain possible indications for a tailored immunization strategy. Methods: We enrolled two cohorts of patients with B-cell lymphoma under rituximab treatment or 3-24 months after treatment. In all patients, we evaluated both humoral and cellular immunological memory toward SARS-CoV-2, after standard vaccination and upon one booster dose. Results: We observed no Spike-specific IgG production in patients (n = 25) under anti-CD20 treatment, whereas patients (n = 16) vaccinated after the completion of chemotherapy showed a higher humoral response. Evaluating SARS-CoV-2-specific T-cell response, we found that patients in both cohorts had developed robust cellular immunity after vaccination. Of the 21 patients (51%) that experienced a breakthrough SARS-CoV-2 infection, only six patients developed severe disease. Interestingly, these six patients had all been treated with rituximab plus bendamustine. Notably, we observed that Spike-specific IgG levels in patients treated with rituximab plus bendamustine were absent or lower compared with those in patients treated with rituximab plus other chemotherapy, whereas Spike-specific T-cell response was not different based on chemotherapy regiment. Discussion: Our results show that, in patients with B-cell lymphoma under rituximab therapy, anti-SARS-CoV-2 mRNA vaccination induces a weak or absent humoral response but a consistent T-cell response. In addition, chemotherapy regimens with bendamustine further reduce patients' ability to mount a Spike-specific humoral response even after a long time period from chemotherapy discontinuation. These results provide evidence that different chemotherapeutics display different immunosuppressive properties that could be taken in to account in the choice of the right drug regimen for the right patient. Moreover, they question whether immunocompromised patients, particularly those treated with bendamustine, need interventions to improve vaccine-induced immune response. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Blood CD62Llow inflammatory eosinophils are related to the severity of asthma and reduced by mepolizumab.

Author

Vultaggio, Alessandra, Accinno, Matteo, Vivarelli, Emanuele, Mecheri, Valentina, Maggiore, Giandomenico, Cosmi, Lorenzo, Parronchi, Paola, Rossi, Olivero, Maggi, Enrico, Gallo, Oreste, and Matucci, Andrea

Subjects
EOSINOPHILS, ASTHMA, BLOOD cells, NASAL polyps, BIOTHERAPY, NASAL tumors
Abstract

Background: Eosinophils have been divided into different subpopulations with distinct phenotypes based on CD62L expression. No data are available regarding the correlation between eosinophils subphenotypes and clinical severity of asthma, as well as the effect of anti‐IL‐5 therapy on these cells. The study investigates the correlation between blood CD62Llow inflammatory eosinophils (iEos) and clinical severity of severe eosinophilic asthma (SEA) and evaluates the impact of mepolizumab on iEos. Methods: 112 patients were screened and were divided in two groups: biological‐naive (n = 51) and biological‐treated patients (n = 61). The Biological‐naive patients were analyzed before treatment (Group A) and 19 out of 51 patients, were longitudinally analyzed before and after treatment with mepolizumab 100 mg s.c/4 weeks (Group B); 32 patients were excluded because they were being treated with other biological therapies. Blood eosinophils were analyzed by FACS and correlated with clinical scores. In vitro effect of IL‐5 and mepolizumab on CD62L expression was assessed. Results: A significant correlation between blood CD62Llow cells and clinical scores of asthma and nasal polyps, as well as the number of asthma exacerbations in the last year was shown in untreated patients. In longitudinally studied patients we observed a marked reduction of CD62Llow cells paralleled by an increase in the proportion of CD62Lbright cells, associated with clinical improvement of asthma control. In vitro, CD62L expression on eosinophils is modulated by IL‐5 and anti‐IL‐5. Conclusion: A positive correlation between CD62Llow iEos and the baseline clinical features of SEA with CRSwNP was shown. Furthermore mepolizumab restores the healthy balance among eosinophils sub‐phenotypes in SEA patients. [ABSTRACT FROM AUTHOR]

Published
2023
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25. First-dose mRNA vaccination is sufficient to reactivate immunological memory to SARS-CoV-2 in subjects who have recovered from COVID-19

Author

Mazzoni, Alessio, Lauria, Nicoletta Di, Maggi, Laura, Salvati, Lorenzo, Vanni, Anna, Capone, Manuela, Lamacchia, Giulia, Mantengoli, Elisabetta, Spinicci, Michele, Zammarchi, Lorenzo, Kiros, Seble Tekle, Rocca, Arianna, Lagi, Filippo, Colao, Maria Grazia, Parronchi, Paola, Scaletti, Cristina, Turco, Lucia, Liotta, Francesco, Rossolini, Gian Maria, Cosmi, Lorenzo, Bartoloni, Alessandro, and Annunziato, Francesco

Subjects
Immunologic memory -- Research, Immunological research, Messenger RNA -- Health aspects, Health care industry
Abstract

The characterization of the adaptive immune response to COVID-19 vaccination in individuals who recovered from SARS-CoV- 2 infection may define current and future clinical practice. To determine the effect of the 2-dose BNT162b2 mRNA COVID-19 vaccination schedule in individuals who recovered from COVID-19 (COVID- 19-recovered subjects) compared with naive subjects, we evaluated SARS-CoV-2 Spike-specific T and B cell responses, as well as specific IgA, IgG, IgM, and neutralizing antibodies titers in 22 individuals who received the BNT162b2 mRNA COVID-19 vaccine, 11 of whom had a previous history of SARS-CoV-2 infection. Evaluations were performed before vaccination and then weekly until 7 days after second injection. Data obtained clearly showed that one vaccine dose is sufficient to increase both cellular and humoral immune response in COVID-19-recovered subjects without any additional improvement after the second dose. On the contrary, the second dose proved mandatory in naive subjects to further enhance the immune response. These findings were further confirmed at the serological level in a larger cohort of naive (n = 68) and COVID-19-recovered (n = 29) subjects, tested up to 50 days after vaccination. These results question whether a second vaccine injection in COVID-19-recovered subjects is required, and indicate that millions of vaccine doses may be redirected to naive individuals, thus shortening the time to reach herd immunity., Introduction As of April 4, 2021, more than 130.4 million people have been diagnosed with COVID-19 worldwide, with more than 2.8 million confirmed deaths (1). COVID-19 is associated with high [...]

Published
2021
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26. Clonally expanded PD‐1‐expressing T cells are enriched in synovial fluid of juvenile idiopathic arthritis patients

Author

Vanni, Anna, primary, Mazzoni, Alessio, additional, Semeraro, Roberto, additional, Capone, Manuela, additional, Maschmeyer, Patrick, additional, Lamacchia, Giulia, additional, Salvati, Lorenzo, additional, Carnasciali, Alberto, additional, Farahvachi, Parham, additional, Giani, Teresa, additional, Simonini, Gabriele, additional, Filocamo, Giovanni, additional, Romano, Micol, additional, Liotta, Francesco, additional, Mashreghi, Mir‐Farzin, additional, Cosmi, Lorenzo, additional, Cimaz, Rolando, additional, Magi, Alberto, additional, Maggi, Laura, additional, and Annunziato, Francesco, additional

Published
2023
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27. EGPA Phenotyping: Not Only ANCA, but Also Eosinophils

Author

Matucci, Andrea, primary, Vivarelli, Emanuele, additional, Perlato, Margherita, additional, Mecheri, Valentina, additional, Accinno, Matteo, additional, Cosmi, Lorenzo, additional, Parronchi, Paola, additional, Rossi, Oliviero, additional, and Vultaggio, Alessandra, additional

Published
2023
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28. Fourth Dose of mRNA COVID-19 Vaccine Transiently Reactivates Spike-Specific Immunological Memory in People Living with HIV (PLWH)

Author

Lamacchia, Giulia, primary, Salvati, Lorenzo, additional, Kiros, Seble Tekle, additional, Mazzoni, Alessio, additional, Vanni, Anna, additional, Capone, Manuela, additional, Carnasciali, Alberto, additional, Farahvachi, Parham, additional, Lagi, Filippo, additional, Di Lauria, Nicoletta, additional, Rocca, Arianna, additional, Colao, Maria Grazia, additional, Liotta, Francesco, additional, Cosmi, Lorenzo, additional, Rossolini, Gian Maria, additional, Bartoloni, Alessandro, additional, Maggi, Laura, additional, and Annunziato, Francesco, additional

Published
2022
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30. Human TH17 Cells

Author

Annunziato, Francesco, Cosmi, Lorenzo, Liotta, Francesco, Maggi, Enrico, Romagnani, Sergio, and Jiang, Shuiping, editor

Published
2011
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35. Primary antibody deficiencies represent an underestimated comorbidity in asthma patients: efficacy of immunoglobulin replacement therapy in asthma control.

Author

Vivarelli, Emanuele, Matucci, Andrea, Parronchi, Paola, Liotta, Francesco, Cosmi, Lorenzo, Rossi, Oliviero, Cavigli, Edoardo, and Vultaggio, Alessandra

Subjects
PRIMARY immunodeficiency diseases, ASTHMATICS, SEROTHERAPY, RESPIRATORY infections, ASTHMA, WHEEZE
Abstract

Primary antibody deficiencies (PAD) are an underestimated comorbidity in asthma and its treatment could improve disease control. a retrospective cohort of asthmatics, affected by IgG subclass deficiency or unclassified antibody deficiency and treated with low-dose intravenous immunoglobulin replacement therapy (IRT) was recruited. Demographic and clinical data, chest CT scan, blood eosinophils, atopy, chronic oral corticosteroid (OCS) therapy were evaluated at baseline. Asthma exacerbations, lower respiratory tract infections (LRTI), upper respiratory tract infections (URTI) and asthma-related hospitalizations were assessed after one and two years of IRT. 57 moderate-to-severe asthmatics were enrolled, mostly affected by T2 low asthma (39/57, 68.4%). After one year, IRT was effective in improving, irrespective of bronchiectasis, atopy, eosinophils and PAD type: 1) trough IgG (826.9 ± 221.3 vs 942.2 ± 195.1 mg/dl; p < 0.0001) and IgG subclasses (IgG1 355.4 ± 88.4 vs 466.7 ± 122.3, p < 0.0001; IgG2 300.1 ± 130.1 vs 347.6 ± 117.3, p < 0.0005) serum levels. 2) asthma exacerbations (6.4 ± 4.1 vs 2.4 ± 1.9, p < 0.0001), LRTI (4.3 ± 3.9 vs 1.3 ± 1.5, p < 0.0001) and hospitalization rate (0.26 ± 0.7 vs 0.05 ± 0.2, p < 0.01). These results persisted after 2 years of therapy. Estimated mean cumulative OCS exposure was reduced by 4500 mg over the 2-year period. low-dose IRT is effective in improving asthma control and lessening OCS burden in asthmatics affected by PAD. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Variants Disrupting CD40L Transmembrane Domain and Atypical X-Linked Hyper-IgM Syndrome: A Case Report With Leishmaniasis and Review of the Literature

Author

Palterer, Boaz, primary, Salvati, Lorenzo, additional, Capone, Manuela, additional, Mecheri, Valentina, additional, Maggi, Laura, additional, Mazzoni, Alessio, additional, Cosmi, Lorenzo, additional, Volpi, Nila, additional, Tiberi, Lucia, additional, Provenzano, Aldesia, additional, Giglio, Sabrina, additional, Parronchi, Paola, additional, Maggiore, Giandomenico, additional, Gallo, Oreste, additional, Bartoloni, Alessandro, additional, Annunziato, Francesco, additional, Zammarchi, Lorenzo, additional, and Liotta, Francesco, additional

Published
2022
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40. CD3+CD4-CD8- double-negative lymphocytes are increased in the aqueous humour of patients affected by retinitis pigmentosa: their possible role in mediating inflammation

Author

Bacherini, Daniela, primary, Maggi, Laura, additional, Sodi, Andrea, additional, Vannozzi, Lorenzo, additional, Mazzoni, Alessio, additional, Capone, Manuela, additional, Virgili, Gianni, additional, Falsini, Benedetto, additional, Cosmi, Lorenzo, additional, Rizzo, Stanislao, additional, Annunziato, Francesco, additional, Giansanti, Fabrizio, additional, and Liotta, Francesco, additional

Published
2022
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41. Functional Deficit of T Regulatory Cells in Fulani, an Ethnic Group with Low Susceptibility to Plasmodium falciparum Malaria

Author

Torcia, Maria G., Santarlasci, Veronica, Cosmi, Lorenzo, Clemente, AnnMaria, Maggi, Laura, Mangano, Valentina D., Verra, Federica, Bancone, Germana, Nebie, Issa, Sirima, Bienvenu Sodiomon, Liotta, Francesco, Frosali, Francesca, Angeli, Roberta, Severini, Carlo, Sannella, Anna R., Bonini, Paolo, Lucibello, Maria, Maggi, Enrico, Garaci, Enrico, Coluzzi, Mario, Cozzolino, Federico, Annunziato, Francesco, Romagnani, Sergio, and Modiano, David

Published
2008
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42. Clinical and immunological features of SARS-CoV-2 breakthrough infections in vaccinated individuals requiring hospitalization

Author

Lamacchia, Giulia, primary, Mazzoni, Alessio, additional, Spinicci, Michele, additional, Vanni, Anna, additional, Salvati, Lorenzo, additional, Peruzzi, Benedetta, additional, Bencini, Sara, additional, Capone, Manuela, additional, Carnasciali, Alberto, additional, Farahvachi, Parham, additional, Rocca, Arianna, additional, Kiros, Seble Tekle, additional, Graziani, Lucia, additional, Zammarchi, Lorenzo, additional, Mencarini, Jessica, additional, Colao, Maria Grazia, additional, Caporale, Roberto, additional, Liotta, Francesco, additional, Cosmi, Lorenzo, additional, Rossolini, Gian Maria, additional, Bartoloni, Alessandro, additional, Maggi, Laura, additional, and Annunziato, Francesco, additional

Published
2022
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43. SARS-CoV-2 Spike-Specific CD4+ T Cell Response Is Conserved Against Variants of Concern, Including Omicron

Author

Mazzoni, Alessio, primary, Vanni, Anna, additional, Spinicci, Michele, additional, Capone, Manuela, additional, Lamacchia, Giulia, additional, Salvati, Lorenzo, additional, Coppi, Marco, additional, Antonelli, Alberto, additional, Carnasciali, Alberto, additional, Farahvachi, Parham, additional, Giovacchini, Nicla, additional, Aiezza, Noemi, additional, Malentacchi, Francesca, additional, Zammarchi, Lorenzo, additional, Liotta, Francesco, additional, Rossolini, Gian Maria, additional, Bartoloni, Alessandro, additional, Cosmi, Lorenzo, additional, Maggi, Laura, additional, and Annunziato, Francesco, additional

Published
2022
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44. Long-lasting cellular immunity to SARS-CoV-2 following infection or vaccination and implications for booster strategies

Author

Mazzoni, Alessio, primary, Vanni, Anna, additional, Spinicci, Michele, additional, Lamacchia, Giulia, additional, Kiros, Seble Tekle, additional, Rocca, Arianna, additional, Capone, Manuela, additional, Di Lauria, Nicoletta, additional, Salvati, Lorenzo, additional, Carnasciali, Alberto, additional, Mantengoli, Elisabetta, additional, Farahvachi, Parham, additional, Zammarchi, Lorenzo, additional, Lagi, Filippo, additional, Colao, Maria Grazia, additional, Liotta, Francesco, additional, Cosmi, Lorenzo, additional, Maggi, Laura, additional, Bartoloni, Alessandro, additional, Rossolini, Gian Maria, additional, and Annunziato, Francesco, additional

Published
2021
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45. Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)

Author

Cossarizza, Andrea, primary, Chang, Hyun‐Dong, additional, Radbruch, Andreas, additional, Abrignani, Sergio, additional, Addo, Richard, additional, Akdis, Mübeccel, additional, Andrä, Immanuel, additional, Andreata, Francesco, additional, Annunziato, Francesco, additional, Arranz, Eduardo, additional, Bacher, Petra, additional, Bari, Sudipto, additional, Barnaba, Vincenzo, additional, Barros‐Martins, Joana, additional, Baumjohann, Dirk, additional, Beccaria, Cristian G., additional, Bernardo, David, additional, Boardman, Dominic A., additional, Borger, Jessica, additional, Böttcher, Chotima, additional, Brockmann, Leonie, additional, Burns, Marie, additional, Busch, Dirk H., additional, Cameron, Garth, additional, Cammarata, Ilenia, additional, Cassotta, Antonino, additional, Chang, Yinshui, additional, Chirdo, Fernando Gabriel, additional, Christakou, Eleni, additional, Čičin‐Šain, Luka, additional, Cook, Laura, additional, Corbett, Alexandra J., additional, Cornelis, Rebecca, additional, Cosmi, Lorenzo, additional, Davey, Martin S., additional, De Biasi, Sara, additional, De Simone, Gabriele, additional, del Zotto, Genny, additional, Delacher, Michael, additional, Di Rosa, Francesca, additional, Di Santo, James, additional, Diefenbach, Andreas, additional, Dong, Jun, additional, Dörner, Thomas, additional, Dress, Regine J., additional, Dutertre, Charles‐Antoine, additional, Eckle, Sidonia B. G., additional, Eede, Pascale, additional, Evrard, Maximilien, additional, Falk, Christine S., additional, Feuerer, Markus, additional, Fillatreau, Simon, additional, Fiz‐Lopez, Aida, additional, Follo, Marie, additional, Foulds, Gemma A., additional, Fröbel, Julia, additional, Gagliani, Nicola, additional, Galletti, Giovanni, additional, Gangaev, Anastasia, additional, Garbi, Natalio, additional, Garrote, José Antonio, additional, Geginat, Jens, additional, Gherardin, Nicholas A., additional, Gibellini, Lara, additional, Ginhoux, Florent, additional, Godfrey, Dale I., additional, Gruarin, Paola, additional, Haftmann, Claudia, additional, Hansmann, Leo, additional, Harpur, Christopher M., additional, Hayday, Adrian C., additional, Heine, Guido, additional, Hernández, Daniela Carolina, additional, Herrmann, Martin, additional, Hoelsken, Oliver, additional, Huang, Qing, additional, Huber, Samuel, additional, Huber, Johanna E., additional, Huehn, Jochen, additional, Hundemer, Michael, additional, Hwang, William Y. K., additional, Iannacone, Matteo, additional, Ivison, Sabine M., additional, Jäck, Hans‐Martin, additional, Jani, Peter K., additional, Keller, Baerbel, additional, Kessler, Nina, additional, Ketelaars, Steven, additional, Knop, Laura, additional, Knopf, Jasmin, additional, Koay, Hui‐Fern, additional, Kobow, Katja, additional, Kriegsmann, Katharina, additional, Kristyanto, H., additional, Krueger, Andreas, additional, Kuehne, Jenny F., additional, Kunze‐Schumacher, Heike, additional, Kvistborg, Pia, additional, Kwok, Immanuel, additional, Latorre, Daniela, additional, Lenz, Daniel, additional, Levings, Megan K., additional, Lino, Andreia C., additional, Liotta, Francesco, additional, Long, Heather M., additional, Lugli, Enrico, additional, MacDonald, Katherine N., additional, Maggi, Laura, additional, Maini, Mala K., additional, Mair, Florian, additional, Manta, Calin, additional, Manz, Rudolf Armin, additional, Mashreghi, Mir‐Farzin, additional, Mazzoni, Alessio, additional, McCluskey, James, additional, Mei, Henrik E., additional, Melchers, Fritz, additional, Melzer, Susanne, additional, Mielenz, Dirk, additional, Monin, Leticia, additional, Moretta, Lorenzo, additional, Multhoff, Gabriele, additional, Muñoz, Luis Enrique, additional, Muñoz‐Ruiz, Miguel, additional, Muscate, Franziska, additional, Natalini, Ambra, additional, Neumann, Katrin, additional, Ng, Lai Guan, additional, Niedobitek, Antonia, additional, Niemz, Jana, additional, Almeida, Larissa Nogueira, additional, Notarbartolo, Samuele, additional, Ostendorf, Lennard, additional, Pallett, Laura J., additional, Patel, Amit A., additional, Percin, Gulce Itir, additional, Peruzzi, Giovanna, additional, Pinti, Marcello, additional, Pockley, A. Graham, additional, Pracht, Katharina, additional, Prinz, Immo, additional, Pujol‐Autonell, Irma, additional, Pulvirenti, Nadia, additional, Quatrini, Linda, additional, Quinn, Kylie M., additional, Radbruch, Helena, additional, Rhys, Hefin, additional, Rodrigo, Maria B., additional, Romagnani, Chiara, additional, Saggau, Carina, additional, Sakaguchi, Shimon, additional, Sallusto, Federica, additional, Sanderink, Lieke, additional, Sandrock, Inga, additional, Schauer, Christine, additional, Scheffold, Alexander, additional, Scherer, Hans U., additional, Schiemann, Matthias, additional, Schildberg, Frank A., additional, Schober, Kilian, additional, Schoen, Janina, additional, Schuh, Wolfgang, additional, Schüler, Thomas, additional, Schulz, Axel R., additional, Schulz, Sebastian, additional, Schulze, Julia, additional, Simonetti, Sonia, additional, Singh, Jeeshan, additional, Sitnik, Katarzyna M., additional, Stark, Regina, additional, Starossom, Sarah, additional, Stehle, Christina, additional, Szelinski, Franziska, additional, Tan, Leonard, additional, Tarnok, Attila, additional, Tornack, Julia, additional, Tree, Timothy I. M., additional, van Beek, Jasper J. P., additional, van de Veen, Willem, additional, van Gisbergen, Klaas, additional, Vasco, Chiara, additional, Verheyden, Nikita A., additional, von Borstel, Anouk, additional, Ward‐Hartstonge, Kirsten A., additional, Warnatz, Klaus, additional, Waskow, Claudia, additional, Wiedemann, Annika, additional, Wilharm, Anneke, additional, Wing, James, additional, Wirz, Oliver, additional, Wittner, Jens, additional, Yang, Jennie H. M., additional, and Yang, Juhao, additional

Published
2021
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46. ARIA-ITALY multidisciplinary consensus on nasal polyposis and biological treatments

Author

Lombardi, Carlo, Asero, Riccardo, Bagnasco, Diego, Blasi, Francesco, Bonini, Matteo, Bussi, Mario, Canevari, Rikki F., Canonica, Giorgio Walter, Castelnuovo, Paolo, Cecchi, Lorenzo, Cosmi, Lorenzo, Gelardi, Matteo, Heffler, Enrico, Indinnimeo, Luciana, Landi, Massimo, Licari, Amelia, Liotta, Francesco, Macchi, Alberto, Malvezzi, Luca, Marseglia, Gianluigi, Micheletto, Claudio, Musarra, Antonino, Peroni, Diego, Piacentini, Giorgio, Poletti, Venerino, Richeldi, Luca, Santoni, Angela, Schiappoli, Michele, Senna, Gianenrico, Vaghi, Adriano, Villani, Alberto, and Passalacqua, Giovanni

Published
2021
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47. Th17 Response

Author

Cosmi, Lorenzo, primary, Liotta, Francesco, additional, and Annunziato, Francesco, additional

Published
2015
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