Search

The United Nations Sustainable Development Goals (UN SDGs) ensure future human well-being. However, they face challenges due to the pressing need to reduce carbon emissions, with nearly 40% originating from the construction sector. With the current global environmental and energy crisis, there is a pressing need to address building carbon emissions and prioritise investments in passive strategies for improving indoor thermal comfort. Exploring fast-growing bio-based materials like bamboo, straw, hemp, and flax directly addresses these concerns, fostering environmental sustainability. Material selection in construction is crucial for advancing the SDGs, for example, promoting sustainable cities and communities (SDG11) and responsible consumption and production (SDG12). This paper proposes a comparative analysis of conventional and bio-based construction materials, focusing on their production stages through life cycle analysis. Tools such as Building Emissions Accounting for Materials (BEAM) and the Methodology for Relative Assessment of Sustainability (MARS) enable a detailed comparison. The results highlight the benefits of bio-based materials in storing carbon more rapidly and their lower environmental impact compared to conventional alternatives. Moreover, bio-based materials contribute to indoor moisture regulation and a healthier indoor environment, underscoring their potential to accelerate progress towards the UN SDGs through informed material choices in design practices. [ABSTRACT FROM AUTHOR]

Stress vulnerability is a critical factor for the development of trauma‐related disorders; however, its biological underpinnings are not clear. We demonstrated that dysfunctions in the X‐linked epigenetic factor methyl‐CpG binding protein 2 (MeCP2) provide trauma vulnerability in male mice. Given the prominent role of sex in stress outcomes, we explored the effects of MeCP2 hypofunctionality in females. Female mice carrying truncated MeCP2 (heterozygous and homozygous) and wild type controls (wt) were tested for fear memory. Stress‐induced corticosterone release and brain expression of hypothalamic‐pituitary‐adrenal (HPA) axis regulatory genes were also evaluated in wt and mutant mice of both sexes. Although heterozygous females displayed a normal stress‐related behavioural profile, homozygous mice showed enhanced memory recall for the threatening context compared to wt, thus recapitulating the phenotype previously evidenced in hemizygous males. Interestingly, MeCP2 truncation abolished the sex differences in stress‐induced corticosterone release, which was found increased in mutant males, whereas blunted in mutant females in a zygosity‐independent manner. Although heterozygous mice did not differ from controls, homozygous females and hemizygous males showed increased hypotalamic Crh and Avp mRNAs and a differentially altered expression of Fkbp5 in cortical areas. Present results demonstrate that in female mice carrying truncated MeCP2, altered stress responsivity is driven by homozygosity, whereas heterozygosity does not lead to maladaptive stress outcomes. MeCP2 dysfunctions thus provide stress vulnerability in mice with sex‐ and zygosity‐dependent outcomes. [ABSTRACT FROM AUTHOR]

Rett syndrome (RTT) is a rare neurodevelopmental disorder, characterized by severe behavioural and physiological symptoms. RTT is caused by mutations in the MECP2 gene in about 95% of cases and to date no cure is available. The endocannabinoid system modulates several physiological processes and behavioural responses that are impaired in RTT and its deregulation has been associated with neuropsychiatric disorders which have symptoms in common with RTT. The present study evaluated the potential therapeutic efficacy for RTT of cannabidivarin (CBDV), a non-psychotropic phytocannabinoid from Cannabis sativa that presents antagonistic properties on the G protein-coupled receptor 55 (GPR55), the most recently identified cannabinoid receptor. Present results demonstrate that systemic treatment with CBDV (2, 20, 100 mg/Kg ip for 14 days) rescues behavioural and brain alterations in MeCP2-308 male mice, a validated RTT model. The CBDV treatment restored the compromised general health status, the sociability and the brain weight in RTT mice. A partial restoration of motor coordination was also observed. Moreover, increased levels of GPR55 were found in RTT mouse hippocampus, suggesting this G protein-coupled receptor as new potential target for the treatment of this disorder. Present findings highlight for the first time for RTT the translational relevance of CBDV, an innovative therapeutic agent that is under active investigation in the clinical setting. [ABSTRACT FROM AUTHOR]