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163 results on '"Cortese, Cherise"'

16. Primary synovial sarcoma of the kidney-A case report and literature review

Author

Tranesh, Ghassan, Cortese, Cherise, Thiel, David, and Zhai, Qihui (Jim)

Subjects
Case Report
Abstract

Primary synovial sarcoma of the kidney is a very rare spindle cell neoplasm that occasionally displays epithelial differentiation. It occurs between 15-60 years of age with a mean of 35 years and a slight male predilection. Most of synovial sarcomas appear as relatively nonspecific soft tissue masses involving the kidney. This rare entity has some overlapping morphologic and immunohistochemical characteristics with other more common renal spindle cell neoplasms. Molecular tools add valuable diagnostic confirmation. We report a 56 year old male who presented to the emergency department with hematuria and abdominal pain. He had an abdominal CT-scan which showed a 6.6 cm enhancing right renal mass. Morphologic and immunohistochemical studies were directed towards synovial sarcoma with confirmation by SYT-SSX gene fusion using RT-PCR molecular technique. We reviewed the literature on the epidemiologic, histologic spectrum, immunophenotypic, clinical significance and prognosis and therapy.

Published
2018

23. A method to reduce variability in scoring antibody-mediated rejection in renal allografts: implications for clinical trials - a retrospective study

Author

Smith, Byron, primary, Cornell, Lynn D., additional, Smith, Maxwell, additional, Cortese, Cherise, additional, Geiger, Xochiquetzal, additional, Alexander, Mariam P., additional, Ryan, Margaret, additional, Park, Walter, additional, Morales Alvarez, Martha Catalina, additional, Schinstock, Carrie, additional, Kremers, Walter, additional, and Stegall, Mark, additional

Published
2018
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28. A method to reduce variability in scoring antibody‐mediated rejection in renal allografts: implications for clinical trials – a retrospective study.

Author

Smith, Byron, Kremers, Walter, Cornell, Lynn D., Alexander, Mariam P., Smith, Maxwell, Ryan, Margaret, Cortese, Cherise, Geiger, Xochiquetzal, Park, Walter, Morales Alvarez, Martha Catalina, Schinstock, Carrie, and Stegall, Mark

Abstract

Summary: Poor reproducibility in scoring antibody‐mediated rejection (ABMR) using the Banff criteria might limit the use of histology in clinical trials. We evaluated the reproducibility of Banff scoring of 67 biopsies by six renal pathologists at three institutions. Agreement by any two pathologists was poor: 44.8–65.7% for glomerulitis, 44.8–67.2% for peritubular capillaritis, and 53.7–80.6% for chronic glomerulopathy (cg). All pathologists agreed on cg0 (n = 20) and cg3 (n = 9) cases, however, many disagreed on scores of cg1 or cg2. The range for the incidence of composite diagnoses by individual pathologists was: 16.4–22.4% for no ABMR; 17.9–47.8% for active ABMR; and 35.8–59.7% for chronic, active antibody‐mediated rejection (cABMR). A "majority rules" approach was then tested in which the scores of three pathologists were used to reach an agreement. This increased consensus both for individual scores (ex. 67.2–77.6% for cg) and for composite diagnoses (ex. 74.6–86.6% cABMR). Modeling using these results showed that differences in individual scoring could affect the outcome assessment in a mock study of cABMR. We conclude that the Banff schema has high variability and a majority rules approach could be used to adjudicate differences between pathologists and reduce variability in scoring in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2019
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29. Langerhan's Cell Sarcoma: Two Case Reports

Author

Kaleem, Tasneem A., primary, Schild, Michael H., additional, Miller, Daniel, additional, Jha, Asit, additional, Cortese, Cherise, additional, Attia, Steven, additional, and Miller, Robert C., additional

Published
2016
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30. Renal Leiomyosarcoma: A Diagnostic Challenge

Author

Valery, Jose R., Tan, Winston, and Cortese, Cherise

Subjects
Article Subject, urologic and male genital diseases
Abstract

Renal leiomyosarcoma is a very rare tumor that clinically and radiographically mimics more common renal malignancies. The infrequency of the condition makes it very difficult to diagnose. A 70-year-old male smoker presented with months of hematuria, right-sided flank pain, and weight loss. Imaging revealed a 3.8-centimeter renal mass that had characteristics similar to renal cell carcinoma. Initial biopsy of the mass was negative for malignancy. Two months later, subsequent imaging revealed what appeared to be metastatic bone lesions. Again, a biopsy of one of the lesions was negative for malignancy. Subsequent ureteral pyeloscopy, ureteroscopic renal pelvis biopsy, and brush cytology were negative for malignancy as well. The decision was made to perform nephrectomy for the removal of the mass. Pathologic analysis revealed renal leiomyosarcoma. This case illustrates the difficulty in diagnosing renal leiomyosarcoma. Repeated pathologic sampling was negative because of the tumor heterogeneity. Prompt diagnosis and treatment are very significant as surgical resection at an early stage offers the best prognosis.

Published
2013
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31. Clinical Activity of Pazopanib in Metastatic Extraosseous Ewing Sarcoma

Author

Attia, Steven, primary, Okuno, Scott H., additional, Robinson, Steven I., additional, Webber, Nicholas P., additional, Indelicato, Daniel J., additional, Jones, Robin L., additional, Bagaria, Sanjay P., additional, Sherman, Courtney, additional, Kozak, Kevin R., additional, Cortese, Cherise M., additional, McFarland, Thomas, additional, Trent, Jonathan C., additional, and Maki, Robert G., additional

Published
2015
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