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Your search keyword '"Cortes-Sempere, María"' showing total 7 results
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7 results on '"Cortes-Sempere, María"'

1. High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response

Author

Arrizabalaga, Olatz, Moreno-Cugnon, Leire, Auzmendi-Iriarte, Jaione, Aldaz, Paula, Ibanez de Caceres, Inmaculada, Garros-Regulez, Laura, Moncho-Amor, Veronica, Torres-Bayona, Sergio, Pernía, Olga, Pintado-Berninches, Laura, Carrasco-Ramirez, Patricia, Cortes-Sempere, María, Rosas, Rocío, Sanchez-Gomez, Pilar, Ruiz, Irune, Caren, Helena, Pollard, Steven, Garcia, Idoia, Sacido, Angel-Ayuso, Lovell-Badge, Robin, Belda-Iniesta, Cristobal, Sampron, Nicolas, Perona, Rosario, and Matheu, Ander

Published
2017
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2. MKP1 repression is required for the chemosensitizing effects of NF-κB and PI3K inhibitors to cisplatin in non-small cell lung cancer

Author

Cortes-Sempere, María, Chattopadhyay, Sharmila, Rovira, Ana, Rodriguez-Fanjul, Vanessa, Belda-Iniesta, Cristobal, Tapia, Marian, Cejas, Paloma, Machado-Pinilla, Rosario, Manguan-García, Cristina, Sánchez-Pérez, Isabel, Nistal, Manuel, Moratilla, Carmen, Castro-Carpeño, Javier de, Gonzalez-Barón, Manuel, Albanell, Joan, and Perona, Rosario

Published
2009
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3. Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer

Author

Moncho-Amor, Verónica, primary, Pintado-Berninches, Laura, additional, Ibañez de Cáceres, Inmaculada, additional, Martín-Villar, Ester, additional, Quintanilla, Miguel, additional, Chakravarty, Probir, additional, Cortes-Sempere, María, additional, Fernández-Varas, Beatriz, additional, Rodriguez-Antolín, Carlos, additional, de Castro, Javier, additional, Sastre, Leandro, additional, and Perona, Rosario, additional

Published
2019
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5. Methylation status ofIGFBP-3as a useful clinical tool for deciding on a concomitant radiotherapy

Author

Pernía, Olga, primary, Belda-Iniesta, Cristobal, additional, Pulido, Veronica, additional, Cortes-Sempere, María, additional, Rodriguez, Carlos, additional, Vera, Olga, additional, Soto, Javier, additional, Jiménez, Julia, additional, Taus, Alvaro, additional, Rojo, Federico, additional, Arriola, Edurne, additional, Rovira, Ana, additional, Albanell, Joan, additional, Macías, M Teresa, additional, de Castro, Javier, additional, Perona, Rosario, additional, and Ibañez de Caceres, Inmaculada, additional

Published
2014
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7. Methylation status of IGFBP-3as a useful clinical tool for deciding on a concomitant radiotherapy

Author

Pernía, Olga, Belda-Iniesta, Cristobal, Pulido, Veronica, Cortes-Sempere, María, Rodriguez, Carlos, Vera, Olga, Soto, Javier, Jiménez, Julia, Taus, Alvaro, Rojo, Federico, Arriola, Edurne, Rovira, Ana, Albanell, Joan, Macías, M Teresa, de Castro, Javier, Perona, Rosario, and Ibañez de Caceres, Inmaculada

Abstract

The methylation status of the IGFBP-3gene is strongly associated with cisplatin sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we found in vitroevidence that linked the presence of an unmethylated promoter with poor response to radiation. Our data also indicate that radiation might sensitize chemotherapy-resistant cells by reactivating IGFBP-3-expression through promoter demethylation, inactivating the PI3K/AKT pathway. We also explored the IGFBP-3methylation effect on overall survival (OS) in a population of 40 NSCLC patients who received adjuvant therapy after R0 surgery. Our results indicate that patients harboring an unmethylated promoter could benefit more from a chemotherapy schedule alone than from a multimodality therapy involving radiotherapy and platinum-based treatments, increasing their OS by 2.5 y (p= .03). Our findings discard this epi-marker as a prognostic factor in a patient population without adjuvant therapy, indicating that radiotherapy does not improve survival for patients harboring an unmethylated IGFBP-3promoter.

Published
2014
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