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6. Allergies and COVID-19 vaccines : An ENDA/EAACI Position paper

Author

Barbaud, Annick, Garvey, Lene Heise, Arcolaci, Alessandra, Brockow, Knut, Mori, Francesca, Mayorga, Cristobalina, Bonadonna, Patrizia, Atanaskovic-Markovic, Marina, Moral, Luis, Zanoni, Giovanna, Pagani, Mauro, Soria, Angele, Jost, Maja, Caubet, Jean-Christoph, Carmo, Abreu, Mona, Al-Ahmad, Alvarez-Perea, Alberto, Bavbek, Sevim, Benedetta, Biagioni, Bilo, M. Beatrice, Blanca-Lopez, Natalia, Bogas, Herrera Gador, Buonomo, Alessandro, Calogiuri, Gianfranco, Carli, Giulia, Cernadas, Josefina, Cortellini, Gabriele, Celik, Gulfem, Demir, Semra, Dona, Inmaculada, Dursun, Adile Berna, Eberlein, Bernadette, Faria, Emilia, Fernandes, Bryan, Garcez, Tomaz, Garcia-Nunez, Ignacio, Gawlik, Radoslaw, Gelincik, Asli, Gomes, Eva, Gooi, Jimmy H. C., Grosber, Martine, Gulen, Theo, Hacard, Florence, Hoarau, Cyrille, Janson, Christer, Johnston, Sebastian L., Joerg, Lukas, Ozdemir, Secil Kepil, Klimek, Ludger, Kosnik, Mitja, Kowalski, Marek L., Kuyucu, Semanur, Kvedariene, Violeta, Laguna, Jose Julio, Lombardo, Carla, Marinho, Susana, Merk, Hans, Meucci, Elisa, Morisset, Martine, Munoz-Cano, Rosa, Murzilli, Francesco, Nakonechna, Alla, Popescu, Florin-Dan, Porebski, Grzegorz, Radice, Anna, Regateiro, Frederico S., Rockmann, Heike, Romano, Antonino, Sargur, Ravishankar, Sastre, Joaquin, Hofmeier, Kathrin Scherer, Sedlackova, Lenka, Sobotkova, Marta, Terreehorst, Ingrid, Treudler, Regina, Walusiak-Skorupa, Jolanta, Wedi, Bettina, Wohrl, Stefan, Zidarn, Mihael, Zuberbier, Torsten, Agache, Ioana, Torres, Maria J., Barbaud, Annick, Garvey, Lene Heise, Arcolaci, Alessandra, Brockow, Knut, Mori, Francesca, Mayorga, Cristobalina, Bonadonna, Patrizia, Atanaskovic-Markovic, Marina, Moral, Luis, Zanoni, Giovanna, Pagani, Mauro, Soria, Angele, Jost, Maja, Caubet, Jean-Christoph, Carmo, Abreu, Mona, Al-Ahmad, Alvarez-Perea, Alberto, Bavbek, Sevim, Benedetta, Biagioni, Bilo, M. Beatrice, Blanca-Lopez, Natalia, Bogas, Herrera Gador, Buonomo, Alessandro, Calogiuri, Gianfranco, Carli, Giulia, Cernadas, Josefina, Cortellini, Gabriele, Celik, Gulfem, Demir, Semra, Dona, Inmaculada, Dursun, Adile Berna, Eberlein, Bernadette, Faria, Emilia, Fernandes, Bryan, Garcez, Tomaz, Garcia-Nunez, Ignacio, Gawlik, Radoslaw, Gelincik, Asli, Gomes, Eva, Gooi, Jimmy H. C., Grosber, Martine, Gulen, Theo, Hacard, Florence, Hoarau, Cyrille, Janson, Christer, Johnston, Sebastian L., Joerg, Lukas, Ozdemir, Secil Kepil, Klimek, Ludger, Kosnik, Mitja, Kowalski, Marek L., Kuyucu, Semanur, Kvedariene, Violeta, Laguna, Jose Julio, Lombardo, Carla, Marinho, Susana, Merk, Hans, Meucci, Elisa, Morisset, Martine, Munoz-Cano, Rosa, Murzilli, Francesco, Nakonechna, Alla, Popescu, Florin-Dan, Porebski, Grzegorz, Radice, Anna, Regateiro, Frederico S., Rockmann, Heike, Romano, Antonino, Sargur, Ravishankar, Sastre, Joaquin, Hofmeier, Kathrin Scherer, Sedlackova, Lenka, Sobotkova, Marta, Terreehorst, Ingrid, Treudler, Regina, Walusiak-Skorupa, Jolanta, Wedi, Bettina, Wohrl, Stefan, Zidarn, Mihael, Zuberbier, Torsten, Agache, Ioana, and Torres, Maria J.

Abstract

Background Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized. Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed. Results No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable. Conclusions These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.

Published
2022
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7. Allergies and COVID-19 vaccines:An ENDA/EAACI Position paper

Author

Barbaud, Annick, Garvey, Lene Heise, Arcolaci, Alessandra, Brockow, Knut, Mori, Francesca, Mayorga, Cristobalina, Bonadonna, Patrizia, Atanaskovic-Markovic, Marina, Moral, Luis, Zanoni, Giovanna, Pagani, Mauro, Soria, Angèle, Jošt, Maja, Caubet, Jean-Christoph, Carmo, Abreu, Mona, Al Ahmad, Alvarez-Perea, Alberto, Bavbek, Sevim, Benedetta, Biagioni, Bilo, M Beatrice, Blanca-López, Natalia, Bogas, Herrera Gádor, Buonomo, Alessandro, Calogiuri, Gianfranco, Carli, Giulia, Cernadas, Josefina, Cortellini, Gabriele, Celik, Gülfem, Demir, Semra, Doña, Inmaculada, Dursun, Adile Berna, Eberlein, Bernadette, Faria, Emilia, Fernandes, Bryan, Garcez, Tomaz, Garcia-Nunez, Ignacio, Gawlik, Radoslaw, Gelincik, Asli, Gomes, Eva, Gooi, Jimmy H. C., Grosber, Martine, Gülen, Theo, Hacard, Florence, Hoarau, Cyrille, Janson, Christer, Johnston, Sebastian L, Joerg, Lukas, Kepil Özdemir, Seçil, Klimek, Ludger, Košnik, Mitja, Kowalski, Marek L, Kuyucu, Semanur, Kvedariene, Violeta, Laguna, Jose Julio, Lombardo, Carla, Marinho, Susana, Merk, Hans, Meucci, Elisa, Morisset, Martine, Munoz-Cano, Rosa, Murzilli, Francesco, Nakonechna, Alla, Popescu, Florin Dan, Porebski, Grzegorz, Radice, Anna, Regateiro, Frederico S., Röckmann, Heike, Romano, Antonino, Sargur, Ravishankar, Sastre, Joaquin, Hofmeier, Kathrin Scherer, Sedláčková, Lenka, Sobotkova, Marta, Terreehorst, Ingrid, Treudler, Regina, Walusiak-Skorupa, Jolanta, Wedi, Bettina, Wöhrl, Stefan, Zidarn, Mihael, Zuberbier, Torsten, Agache, Ioana, Torres, Maria J., Barbaud, Annick, Garvey, Lene Heise, Arcolaci, Alessandra, Brockow, Knut, Mori, Francesca, Mayorga, Cristobalina, Bonadonna, Patrizia, Atanaskovic-Markovic, Marina, Moral, Luis, Zanoni, Giovanna, Pagani, Mauro, Soria, Angèle, Jošt, Maja, Caubet, Jean-Christoph, Carmo, Abreu, Mona, Al Ahmad, Alvarez-Perea, Alberto, Bavbek, Sevim, Benedetta, Biagioni, Bilo, M Beatrice, Blanca-López, Natalia, Bogas, Herrera Gádor, Buonomo, Alessandro, Calogiuri, Gianfranco, Carli, Giulia, Cernadas, Josefina, Cortellini, Gabriele, Celik, Gülfem, Demir, Semra, Doña, Inmaculada, Dursun, Adile Berna, Eberlein, Bernadette, Faria, Emilia, Fernandes, Bryan, Garcez, Tomaz, Garcia-Nunez, Ignacio, Gawlik, Radoslaw, Gelincik, Asli, Gomes, Eva, Gooi, Jimmy H. C., Grosber, Martine, Gülen, Theo, Hacard, Florence, Hoarau, Cyrille, Janson, Christer, Johnston, Sebastian L, Joerg, Lukas, Kepil Özdemir, Seçil, Klimek, Ludger, Košnik, Mitja, Kowalski, Marek L, Kuyucu, Semanur, Kvedariene, Violeta, Laguna, Jose Julio, Lombardo, Carla, Marinho, Susana, Merk, Hans, Meucci, Elisa, Morisset, Martine, Munoz-Cano, Rosa, Murzilli, Francesco, Nakonechna, Alla, Popescu, Florin Dan, Porebski, Grzegorz, Radice, Anna, Regateiro, Frederico S., Röckmann, Heike, Romano, Antonino, Sargur, Ravishankar, Sastre, Joaquin, Hofmeier, Kathrin Scherer, Sedláčková, Lenka, Sobotkova, Marta, Terreehorst, Ingrid, Treudler, Regina, Walusiak-Skorupa, Jolanta, Wedi, Bettina, Wöhrl, Stefan, Zidarn, Mihael, Zuberbier, Torsten, Agache, Ioana, and Torres, Maria J.

Abstract

Background: Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized. Method: Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed. Results: No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1—anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2—anaphylaxis to oral/topical PEG containing products; 3—recurrent anaphylaxis of unknown cause; 4—suspected or confirmed allergy to any mRNA vaccine; and 5—confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable. Conclusions: These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.

Published
2022

8. Peanut allergy in Italy: A unique Italian perspective

Author

Asero, Riccardo, Nucera, Eleonora, Rizzi, Angela, Aruanno, Arianna, Uasuf, Carina G., Manzotti, Giuseppina, Villalta, Danilo, Conte, Mariaelisabetta, Pastorello, Elide A., Losappio, Laura, Schroeder, Jan V., Pinter, Elena, Miglionico, Marzia, Vantaggio, Lorenzo, Macchia, Donatella, Radice, Anna, Marra, Alessandro M., Barzaghi, Claudio, Santucci, Annalisa, Cortellini, Gabriele, Peveri, Silvia, Montagni, Marcello, Demonte, Antongiulio, Borrelli, Paolo, Errico, Micol A., Rivolta, Federica, Pravettoni, Valerio, Sangalli, Andrea, Magnani, Monica, Celi, Giorgio, Yang, Baoran, Costantino, Maria T., Deleonardi, Gaia, Boni, Elisa, Gattoni, Marco, Rizzini, Fabio Lodi, Di Paolo, Camilla, Montera, Mariacarmela, Giordano, Annaclaudia, De Carli, Marco, Murzilli, Francesco, Fumagalli, Federica, Maffeis, Laura, Ghiglioni, Daniele Giovanni, Centonze, Simone, Di Lizia, Michela, Calafiore, Paolo, Scala, Enrico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Rizzi, Angela (ORCID:0000-0002-6795-746X), Asero, Riccardo, Nucera, Eleonora, Rizzi, Angela, Aruanno, Arianna, Uasuf, Carina G., Manzotti, Giuseppina, Villalta, Danilo, Conte, Mariaelisabetta, Pastorello, Elide A., Losappio, Laura, Schroeder, Jan V., Pinter, Elena, Miglionico, Marzia, Vantaggio, Lorenzo, Macchia, Donatella, Radice, Anna, Marra, Alessandro M., Barzaghi, Claudio, Santucci, Annalisa, Cortellini, Gabriele, Peveri, Silvia, Montagni, Marcello, Demonte, Antongiulio, Borrelli, Paolo, Errico, Micol A., Rivolta, Federica, Pravettoni, Valerio, Sangalli, Andrea, Magnani, Monica, Celi, Giorgio, Yang, Baoran, Costantino, Maria T., Deleonardi, Gaia, Boni, Elisa, Gattoni, Marco, Rizzini, Fabio Lodi, Di Paolo, Camilla, Montera, Mariacarmela, Giordano, Annaclaudia, De Carli, Marco, Murzilli, Francesco, Fumagalli, Federica, Maffeis, Laura, Ghiglioni, Daniele Giovanni, Centonze, Simone, Di Lizia, Michela, Calafiore, Paolo, Scala, Enrico, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Rizzi, Angela (ORCID:0000-0002-6795-746X)

Abstract

Background Peanut allergy has not been well characterized in Italy. Objective Our aim was to better define the clinical features of peanut allergy in Italy and to detect the peanut proteins involved in allergic reactions. Methods A total of 22 centers participated in a prospective survey of peanut allergy over a 6-month period. Clinical histories were confirmed by in vivo and/or in vitro diagnostic means in all cases. Potential risk factors for peanut allergy occurrence were considered. Levels of IgE to Arachis hypogea (Ara h) 1, 2, 3, 6, 8, and 9 and profilin were measured. Results A total of 395 patients (aged 2-80 years) were enrolled. Of the participants, 35% reported local reactions, 38.2% reported systemic reactions, and 26.6% experienced anaphylaxis. The sensitization profile was dominated by Ara h 9 (77% of patients were sensitized to it), whereas 35% were sensitized to pathogenesis-related protein 10 (PR-10) and 26% were sensitized to seed storage proteins (SSPs). Sensitization to 2S albumins (Ara h 2 and Ara h 6) or lipid transfer protein (LTP) was associated with the occurrence of more severe symptoms, whereas profilin and PR-10 sensitization were associated with milder symptoms. Cosensitization to profilin reduced the risk of severe reactions in both Ara h 2– and LTP-sensitized patients. SSP sensitization prevailed in younger patients whereas LTP prevailed in older patients (P < .01). SSP sensitization occurred mainly in northern Italy, whereas LTP sensitization prevailed in Italy's center and south. Atopic dermatitis, frequency of peanut ingestion, peanut consumption by other family members, or use of peanut butter did not seem to be risk factors for peanut allergy onset. Conclusions In Italy, peanut allergy is rare and dominated by LTP in the country's center and south and by SSP in the north. These 2 sensitizations seem mutually exclusive. The picture differs from that in Anglo-Saxon countries.

Published
2022

10. Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper

Author

Barbaud, Annick, primary, Garvey, Lene Heise, additional, Arcolaci, Alessandra, additional, Brockow, Knut, additional, Mori, Francesca, additional, Mayorga, Cristobalina, additional, Bonadonna, Patrizia, additional, Atanaskovic‐Markovic, Marina, additional, Moral, Luis, additional, Zanoni, Giovanna, additional, Pagani, Mauro, additional, Soria, Angèle, additional, Jošt, Maja, additional, Caubet, Jean‐Christoph, additional, Carmo, Abreu, additional, Mona, Al‐Ahmad, additional, Alvarez‐Perea, Alberto, additional, Bavbek, Sevim, additional, Benedetta, Biagioni, additional, Bilo, M.Beatrice, additional, Blanca‐López, Natalia, additional, Bogas, Herrera Gádor, additional, Buonomo, Alessandro, additional, Calogiuri, Gianfranco, additional, Carli, Giulia, additional, Cernadas, Josefina, additional, Cortellini, Gabriele, additional, Celik, Gülfem, additional, Demir, Semra, additional, Doña, Inmaculada, additional, Dursun, Adile Berna, additional, Eberlein, Bernadette, additional, Faria, Emilia, additional, Fernandes, Bryan, additional, Garcez, Tomaz, additional, Garcia‐Nunez, Ignacio, additional, Gawlik, Radoslaw, additional, Gelincik, Asli, additional, Gomes, Eva, additional, Gooi, Jimmy H. C., additional, Grosber, Martine, additional, Gülen, Theo, additional, Hacard, Florence, additional, Hoarau, Cyrille, additional, Janson, Christer, additional, Johnston, Sebastian L., additional, Joerg, Lukas, additional, Kepil Özdemir, Seçil, additional, Klimek, Ludger, additional, Košnik, Mitja, additional, Kowalski, Marek L., additional, Kuyucu, Semanur, additional, Kvedariene, Violeta, additional, Laguna, Jose Julio, additional, Lombardo, Carla, additional, Marinho, Susana, additional, Merk, Hans, additional, Meucci, Elisa, additional, Morisset, Martine, additional, Munoz‐Cano, Rosa, additional, Murzilli, Francesco, additional, Nakonechna, Alla, additional, Popescu, Florin‐Dan, additional, Porebski, Grzegorz, additional, Radice, Anna, additional, Regateiro, Frederico S., additional, Röckmann, Heike, additional, Romano, Antonino, additional, Sargur, Ravishankar, additional, Sastre, Joaquin, additional, Scherer Hofmeier, Kathrin, additional, Sedláčková, Lenka, additional, Sobotkova, Marta, additional, Terreehorst, Ingrid, additional, Treudler, Regina, additional, Walusiak‐Skorupa, Jolanta, additional, Wedi, Bettina, additional, Wöhrl, Stefan, additional, Zidarn, Mihael, additional, Zuberbier, Torsten, additional, Agache, Ioana, additional, and Torres, Maria J., additional

Published
2022
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11. PEANUT ALLERGY IN ITALY: A UNIQUE ITALIAN PERSPECTIVE

Author

Asero, Riccardo, primary, Nucera, Eleonora, additional, Rizzi, Angela, additional, Aruanno, Arianna, additional, Uasuf, Carina G., additional, Manzotti, Giuseppina, additional, Villalta, Danilo, additional, Conte, Mariaelisabetta, additional, Pastorello, Elide A., additional, Losappio, Laura, additional, Schroeder, Jan V., additional, Pinter, Elena, additional, Miglionico, Marzia, additional, Vantaggio, Lorenzo, additional, Macchia, Donatella, additional, Radice, Anna, additional, Marra, Alessandro M., additional, Barzaghi, Claudio, additional, Santucci, Annalisa, additional, Cortellini, Gabriele, additional, Peveri, Silvia, additional, Montagni, Marcello, additional, Demonte, Antongiulio, additional, Borrelli, Paolo, additional, Errico, Micol A., additional, Rivolta, Federica, additional, Pravettoni, Valerio, additional, Sangalli, Andrea, additional, Magnani, Monica, additional, Celi, Giorgio, additional, Yang, Baoran, additional, Costantino, Maria T., additional, Deleonardi, Gaia, additional, Boni, Elisa, additional, Gattoni, Marco, additional, Lodi Rizzini, Fabio, additional, Di Paolo, Camilla, additional, Montera, Mariacarmela, additional, Giordano, Annaclaudia, additional, De Carli, Marco, additional, Murzilli, Francesco, additional, Fumagalli, Federica, additional, Maffeis, Laura, additional, GhiglionI, Daniele, additional, Centonze, Simone, additional, Di Lizia, Michela, additional, Calafiore, Paolo, additional, and Scala, Enrico, additional

Published
2022
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13. Systemic allergic reactions induced by labile plant‐food allergens: Seeking potential cofactors. A multicenter study

Author

Asero, Riccardo, primary, Ariano, Renato, additional, Aruanno, Arianna, additional, Barzaghi, Claudio, additional, Borrelli, Paolo, additional, Busa, Moira, additional, Celi, Giorgio, additional, Cinquini, Massimo, additional, Cortellini, Gabriele, additional, D’Auria, Francesca, additional, De Carli, Marco, additional, Di Paolo, Camilla, additional, Garzi, Giulia, additional, Lodi Rizzini, Fabio, additional, Magnani, Monica, additional, Manzotti, Giuseppina, additional, Marra, Alessandro, additional, Miceli Sopo, Stefano, additional, Murzilli, Francesco, additional, Nucera, Eleonora, additional, Pinter, Elena, additional, Pravettoni, Valerio, additional, Rivolta, Federica, additional, Rizzi, Angela, additional, Saporiti, Nicoletta, additional, Scala, Enrico, additional, Villalta, Danilo, additional, Yacoub, Mona‐Rita, additional, and Zisa, Giuliana, additional

Published
2020
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17. House dust mite allergy in Italy. Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real life, multicenter study

Author

Celi, Giorgio, Brusca, Ignazio, Scala, Enrico, Villalta, Danilo, Pastorello, Elide, Farioli, Laura, Cortellini, Gabriele, Deleonardi, Gaia, Galati, Pietro, Losappio, Laura, Manzotti, Giuseppina, Pirovano, Barbara, Muratore, Lionello, Murzilli, Francesco, Cucinelli, Francesco, Musarra, Antonino, Cilia, Marcello, Nucera, Eleonora, Aruanno, Arianna, Ria, Francesco, Patria, Maria Francesca, Varin, Elena, Polillo, Battista Roberto, Sargentini, Vittorio, Quercia, Oliviero, Uasuf, Carina Gabriela, Zampogna, Stefania, Carollo, Michela, Graci, Stefania, Amato, Stefano, Mistrello, Gianni, Asero, Riccardo, Nucera, Eleonora (ORCID:0000-0002-0565-7680), Ria, Francesco (ORCID:0000-0002-8444-0307), Celi, Giorgio, Brusca, Ignazio, Scala, Enrico, Villalta, Danilo, Pastorello, Elide, Farioli, Laura, Cortellini, Gabriele, Deleonardi, Gaia, Galati, Pietro, Losappio, Laura, Manzotti, Giuseppina, Pirovano, Barbara, Muratore, Lionello, Murzilli, Francesco, Cucinelli, Francesco, Musarra, Antonino, Cilia, Marcello, Nucera, Eleonora, Aruanno, Arianna, Ria, Francesco, Patria, Maria Francesca, Varin, Elena, Polillo, Battista Roberto, Sargentini, Vittorio, Quercia, Oliviero, Uasuf, Carina Gabriela, Zampogna, Stefania, Carollo, Michela, Graci, Stefania, Amato, Stefano, Mistrello, Gianni, Asero, Riccardo, Nucera, Eleonora (ORCID:0000-0002-0565-7680), and Ria, Francesco (ORCID:0000-0002-8444-0307)

Abstract

House dust mites (HDM) area major cause of respiratory allergy and of perennial asthmaworldwide. 32 allergens for Dermatophagoidesfarinae(D2) and 21 for Dermatophagoides pteronyssinus(D1) have been detectedso farand novel allergens are still being reported(1). Der p 23, a gut-derived peritrophin present in the outer membrane of mite feces (2),has been recognized as a major allergen (2,3).Der p 1, Der p 2, Der p 23, and Der p 10(tropomyosin)are theonly allergens currently available for the component-resolved diagnosis of HDMallergyon ImmunoCAP.The clinical relevance of Der p 23 is only partially defined, and the prevalence and relevance of the exclusive sensitization to allergensother than groups1, 2, 10, and 23 has received little attention so far. We addressed these aspects ina large multicenter study.

Published
2019

18. Large local reactions to Hymenoptera stings: Outcome of re‐stings in real life

Author

Bilò, Maria Beatrice, primary, Martini, Matteo, additional, Pravettoni, Valerio, additional, Bignardi, Donatella, additional, Bonadonna, Patrizia, additional, Cortellini, Gabriele, additional, Kosinska, Magdalena, additional, Macchia, Donatella, additional, Mauro, Marina, additional, Meucci, Elisa, additional, Nittner‐Marszalska, Marita, additional, Patella, Vincenzo, additional, Pio, Roberta, additional, Quercia, Oliviero, additional, Reccardini, Federico, additional, Ridolo, Erminia, additional, Rudenko, Michael, additional, and Severino, Maurizio, additional

Published
2019
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19. House dust mite allergy in Italy—Diagnostic and clinical relevance of Der p 23 (and of minor allergens): A real‐life, multicenter study

Author

Celi, Giorgio, primary, Brusca, Ignazio, additional, Scala, Enrico, additional, Villalta, Danilo, additional, Pastorello, Elide, additional, Farioli, Laura, additional, Cortellini, Gabriele, additional, Deleonardi, Gaia, additional, Galati, Pietro, additional, Losappio, Laura, additional, Manzotti, Giuseppina, additional, Pirovano, Barbara, additional, Muratore, Lionello, additional, Murzilli, Francesco, additional, Cucinelli, Francesco, additional, Musarra, Antonino, additional, Cilia, Marcello, additional, Nucera, Eleonora, additional, Aruanno, Arianna, additional, Ria, Francesco, additional, Patria, Maria Francesca, additional, Varin, Elena, additional, Polillo, Battista Roberto, additional, Sargentini, Vittorio, additional, Quercia, Oliviero, additional, Gabriela Uasuf, Carina, additional, Zampogna, Stefania, additional, Carollo, Michela, additional, Graci, Stefania, additional, Amato, Stefano, additional, Mistrello, Gianni, additional, and Asero, Riccardo, additional

Published
2019
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21. Systemic allergic reactions induced by labile plant‐food allergens: Seeking potential cofactors. A multicenter study.

Author

Asero, Riccardo, Ariano, Renato, Aruanno, Arianna, Barzaghi, Claudio, Borrelli, Paolo, Busa, Moira, Celi, Giorgio, Cinquini, Massimo, Cortellini, Gabriele, D'Auria, Francesca, De Carli, Marco, Di Paolo, Camilla, Garzi, Giulia, Lodi Rizzini, Fabio, Magnani, Monica, Manzotti, Giuseppina, Marra, Alessandro, Miceli Sopo, Stefano, Murzilli, Francesco, and Nucera, Eleonora

Subjects
ALLERGIES, ALLERGENS, FLUID foods, FERTILIZERS, SOYMILK, COFACTORS (Biochemistry), CAMEL milk
Abstract

Background: Heat‐and‐pepsin‐sensitive plant food allergens (PR‐10 and profilin) sometimes cause systemic reaction. Objective: To detect the risk factors for systemic reactions induced by labile food allergens. Methods: A retrospective multicenter study was performed on patients with a documented history of systemic allergic reaction to labile plant food allergens and on age‐matched controls with a history of oral allergy syndrome (OAS) induced by the same foods. Offending foods, their amount, and state (solid or liquid), and potential cofactors (nonsteroidal anti‐inflammatory drugs, protonic pump inhibitors, exercise, alcohol, and fasting) were considered. Results: We studied 89 patients and 81 controls. Sensitization to PR‐10 or profilin, IgE to Bet v 1 and/or Bet v 2, and foods causing OAS were similar in the two groups. Twenty patients experienced >1 systemic allergic reaction. Tree nuts, Rosaceae, Apiaceae, and soymilk were the main offending foods. Seventeen (19%) patients were taking a PPI when the systemic reaction occurred (vs 5% in controls; P <.025). The ingestion of the offending food in liquid form (soymilk) was frequent among patients (15%) but unusual among controls (2%; P <.025). Soy milk‐induced systemic reactions were independent of PPI treatment. Fasting and excess of allergen, but not NSAID and exercise, were other relevant cofactors for systemic reactions. Systemic reactions occurred without any identifiable cofactor in 39 (44%) cases. Conclusion: PR‐10‐ and profilin‐induced systemic reactions are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR‐10 hypersensitive patients and should be avoided. [ABSTRACT FROM AUTHOR]

Published
2021
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22. Clinical presentation and management practice of systemic mastocytosis. A survey on 460 Italian patients

Author

Pieri, Lisa, Bonadonna, Patrizia, Elena, Chiara, Papayannidis, Cristina, Grifoni, Federica Irene, Rondoni, Michela, Girlanda, Stefania, Mauro, Marina, Magliacane, Diomira, Elli, Elena Maria, Iorno, Maria Loredana, Almerigogna, Fabio, Scarfì, Federica, Salerno, Roberto, Fanelli, Tiziana, Gesullo, Francesca, Corbizi Fattori, Giuditta, Bonifacio, Massimiliano, Perbellini, Omar, Artuso, Anna, Soverini, Simona, De Benedittis, Caterina, Muratori, Simona, Pravettoni, Valerio, Cova, Vittoria, Cortellini, Gabriele, Cortelezzi, Agostino, Martinelli, Giovanni, Triggiani, Massimo, Merante, Serena, Vannucchi, Alessandro Maria, Zanotti, Roberta, CICERI, FABIO, Pieri, L, Bonadonna, P, Elena, C, Papayannidis, C, Grifoni, Fi, Rondoni, M, Girlanda, S, Mauro, M, Magliacane, D, Elli, Em, Iorno, Ml, Almerigogna, F, Scarfì, F, Salerno, R, Fanelli, T, Gesullo, F, Corbizi Fattori, G, Bonifacio, M, Perbellini, O, Artuso, A, Soverini, S, De Benedittis, C, Muratori, S, Pravettoni, V, Cova, V, Cortellini, G, Ciceri, F, Cortelezzi, A, Martinelli, G, Triggiani, M, Merante, S, Vannucchi, Am, Zanotti, R., Pieri, Lisa, Bonadonna, Patrizia, Elena, Chiara, Papayannidis, Cristina, Grifoni, Federica Irene, Rondoni, Michela, Girlanda, Stefania, Mauro, Marina, Magliacane, Diomira, Elli, Elena Maria, Iorno, Maria Loredana, Almerigogna, Fabio, Scarfì, Federica, Salerno, Roberto, Fanelli, Tiziana, Gesullo, Francesca, Corbizi Fattori, Giuditta, Bonifacio, Massimiliano, Perbellini, Omar, Artuso, Anna, Soverini, Simona, De Benedittis, Caterina, Muratori, Simona, Pravettoni, Valerio, Cova, Vittoria, Cortellini, Gabriele, Ciceri, Fabio, Cortelezzi, Agostino, Martinelli, Giovanni, Triggiani, Massimo, Merante, Serena, Vannucchi, Alessandro Maria, and Zanotti, Roberta

Subjects
Adult, Male, Adolescent, KIT D816V MUTATION, PERIPHERAL-BLOOD, DIAGNOSIS, Young Adult, Mastocytosis, Systemic, indolent, Surveys and Questionnaires, Humans, mastocytosis,prognosis,indolent, POPULATION, Aged, Retrospective Studies, Aged, 80 and over, mastocytosis, Age Factors, Disease Management, Hematology, Middle Aged, Prognosis, Survival Rate, C-KIT, Early Diagnosis, Italy, Disease Progression, MAST-CELLS, Female, SPANISH NETWORK, BONE-MARROW MASTOCYTOSIS, CONSENSUS, LEUKEMIA
Abstract

Systemic mastocytosis is a rare heterogeneous myeloproliferative neoplasm characterized by abnormal proliferation and activation of mast cells. We describe a large multicentre series of 460 adult patients with systemic mastocytosis, with a diagnosis based on WHO 2008 criteria, in a “real-life” setting of ten Italian centers with dedicated multidisciplinary programs. We included indolent forms with (n = 255) and without (n = 165) skin lesions, smouldering (n = 20), aggressive (n = 28), associated with other hematological diseases mastocytosis (n = 21) and mast cell leukemia (n = 1). This series was uniquely characterized by a substantial proportion of patients with low burden of neoplastic mast cells; notably, 38% of cases were diagnosed using only minor diagnostic criteria according to WHO 2008 classification, underlying the feasibility of early diagnosis where all diagnostic approaches are made available. This has particular clinical relevance for prevention of anaphylaxis manifestations, that were typically associated with indolent forms. In multivariate analysis, the most important features associated with shortened overall survival were disease subtype and age at diagnosis >60 years. Disease progression was correlated with mastocytosis subtype and thrombocytopenia. As many as 32% of patients with aggressive mastocytosis suffered from early evolution into acute leukemia. Overall, this study provides novel information about diagnostic approaches and current presentation of patients with SM and underlines the importance of networks and specialized centers to facilitate early diagnosis and prevent disease-associated manifestations. Am. J. Hematol. 91:692–699, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

27. A survey of clinical features of allergic rhinitis in adults

Author

Frati, Franco, Dell’Albani, Ilaria, Passalacqua, Giovanni, Bonini, Sergio, Rossi, Oliviero, Senna, Gianenrico, Incorvaia, Cristoforo, Albano, Monica, Allegretti, Lucrezia, Altomonte, Giorgia, Antico, Andrea, Arena, ANTONIO IGNAZIO, Ariano, Renato, Arigliano, Pasquale, Arrigoni, Paola, Arsieni, Augusto, Aruanno, Arianna, Bernardis, Paola, Berra, Adriano, Billeri, Lucia, Boccafogli, Arrigo, Borghesan, Franco, Borgonovo, Linda, Borrelli, Paolo, Braga, Marina, Bresciani, Megan, Bruno, Guglielmo, Bruno, Massimo, Bruzzese, Domenico, Buonomo, Alessandro, Cadario, Gianni, Candi, Paolo, Cantone, Renato, Capretti, Stefania, Carabelli, Anna, Caramazza, Rino, Carbonara, Annamaria, Carosso, Aurelia, Caruso, Cristiano, Caruso, Riccardo, Casino, Giuseppe, Casotto, Stefano, Castellano, Francesco, Castiglioni, Gloria, Cecchi, Lidia, Chiarini, Francesca, Bianchi, Fulvia Chieco, Cinquepalmi, Giuseppe, Cinquini, Massimo, Cocchi, Silvia, Colangelo, Caterina, Colombo, Giselda, Cortellini, Gabriele, Crescioli, Stefano, Crimi, Nunzio, Cucinelli, Francesco, Curcio, Antonio, Cutajar, Marina, D’Amato, Gennaro, De Palma, Rafaele, Del Pozzo, Giuseppe, Torre, Fabrizio Della, Donne, Pantalea Delle, Di Claudio, Fabio, Di Leo, Elisabetta, Di Lorenzo, Gabriele, Di Marco, Giuseppe, Di Rocco Cesinaro, Paola, Distaso, Maria, Ditta, Vito, Emiliani, Francesca, Ermini, Giuseppe, Facchetti, Susanna, Farsi, Alessandro, Favero, Elisabetta, Folletti, Ilenia, Franchini, Maurizio, Gammeri, Enrico, Gangemi, Sebastiano, Gani, Federica, Gargano, Domenico, Giannoccaro, Francesco, Giro, Giuseppina, Gracefa, Dario, Greco, Giacomo, Guarnieri, Gabriella, Ingrassia, Antonino, Intravaia, Rossella, Iorno, Loredana, Piana, Simona La, Rosa, Luigi La, Laddaga, Rocco, Lamanna, Carlo, Landi, Massimo, Leonetti, Luigi, Barone, Stefania Leto, Liccardi, Gennaro, Lodi Rizzini, Fabio, Losappio, Laura, Lucivero, Giacomo, Macchia, Donatella, Madonna, Francesco, Mafezzoni, Enrico, Mancuso, Vincenzo, Manetti, Roberto, Manfredi, Giacomo, Manzoni, Silvia, Marcotulli, Maria, Marengo, Fulvia, D’Ippolito, Gianna Maria, Masieri, Simonetta, Matucci, Andrea, Mauro, Marina, Melchiorre, Antonietta, Menzella, Francesco, Micucci, Corrado, Mietta, Sabrina, Milanese, Manlio, Minetti, Stefano, Modiano, Ambra, Modica, Stella, Moinaghi, Marcello, Mondino, Michela, Munno, Giorgio, Muratore, Lionello, Murzilli, Francesco, Natoli, Rosalba, Nebiolo, Franco, Nettis, Eustachio, Olivieri, Elisa, Pannofno, Alessandro, Parpanesi, Mauro, Patella, Vincenzo, Petraroli, Angelica, Peveri, Silvia, Piantanida, Marta, Pietrafesa, Maria, Pinter, Elena, Pizzimenti, Stefano, Pompilio, Luana, Porcaro, Valeria, Prandini, Paolo, Pravettoni, Valerio, Pugliese, Salvatore, Quarta, Carlo, Quecchia, Cristina, Quercia, Oliviero, Quilleri, Roberto, Raie, Alberto, Randazzo, Salvatore, Ridolo, Erminia, Rolla, Giovanni, Romano, Antonino, Rota, Federica, Russello, Marina, Santucci, Annalisa, Savi, Eleonora, Scarantino, Giovanna, Scarpa, Sergio, Schiavino, Domenico, Sciacca, Angelo Rito, Serra, Paolo, Severino, Maurizio, Sirena, Alberto, Spadaro, Giuseppe, Spina, Francesca, Sugamiele, Mario, Taddeo, Giordano, Ventura, Maria Teresa, Testi, Sergio, Tombetti, Enrico, Tosoni, Cinzia, Triggiani, Massimo, Tripodi, Salvatore, Vallerani, Elisabetta, Vargiu, Arnoldo, Varricchio, Attilio, Zambito, Marcello, Zanforlin, Mario, Zanoni, Giovanna, Frati, F, Dell’Albani, I, Passalacqua, G, Bonini, Sergio, Rossi, O, Senna, G, Incorvaia, C, Adult SURF Study, Group, DE PALMA, Raffaele, Frati, Franco, Dell’Albani, Ilaria, Passalacqua, Giovanni, Rossi, Oliviero, Senna, Gianenrico, Incorvaia, Cristoforo, Albano, Monica, Allegretti, Lucrezia, Altomonte, Giorgia, Antico, Andrea, Arena, Antonio, Ariano, Renato, Arigliano, Pasquale, Arrigoni, Paola, Arsieni, Augusto, Aruanno, Arianna, Bernardis, Paola, Berra, Adriano, Billeri, Lucia, Boccafogli, Arrigo, Borghesan, Franco, Borgonovo, Linda, Borrelli, Paolo, Braga, Marina, Bresciani, Megan, Bruno, Guglielmo, Bruno, Massimo, Bruzzese, Domenico, Buonomo, Alessandro, Cadario, Gianni, Candi, Paolo, Cantone, Renato, Capretti, Stefania, Carabelli, Anna, Caramazza, Rino, Carbonara, Annamaria, Carosso, Aurelia, Caruso, Cristiano, Caruso, Riccardo, Casino, Giuseppe, Casotto, Stefano, Castellano, Francesco, Castiglioni, Gloria, Cecchi, Lidia, Chiarini, Francesca, Bianchi, Fulvia Chieco, Cinquepalmi, Giuseppe, Cinquini, Massimo, Cocchi, Silvia, Colangelo, Caterina, Colombo, Giselda, Cortellini, Gabriele, Crescioli, Stefano, Crimi, Nunzio, Cucinelli, Francesco, Curcio, Antonio, Cutajar, Marina, D’Amato, Gennaro, De Palma, Rafaele, Del Pozzo, Giuseppe, Torre, Fabrizio, Donne, Pantalea Delle, Di Claudio, Fabio, Di Leo, Elisabetta, Di Lorenzo, Gabriele, Di Marco, Giuseppe, Di Rocco Cesinaro, Paola, Distaso, Maria, Ditta, Vito, Emiliani, Francesca, Ermini, Giuseppe, Facchetti, Susanna, Farsi, Alessandro, Favero, Elisabetta, Folletti, Ilenia, Franchini, Maurizio, Gammeri, Enrico, Gangemi, Sebastiano, Gani, Federica, Gargano, Domenico, Giannoccaro, Francesco, Giro, Giuseppina, Gracefa, Dario, Greco, Giacomo, Guarnieri, Gabriella, Ingrassia, Antonino, Intravaia, Rossella, Iorno, Loredana, Piana, Simona La, Rosa, Luigi La, Laddaga, Rocco, Lamanna, Carlo, Landi, Massimo, Leonetti, Luigi, Barone, Stefania Leto, Liccardi, Gennaro, Lodi-Rizzini, Fabio, Losappio, Laura, Lucivero, Giacomo, Macchia, Donatella, Madonna, Francesco, Mafezzoni, Enrico, Mancuso, Vincenzo, Manetti, Roberto, Manfredi, Giacomo, Manzoni, Silvia, Marcotulli, Maria, Marengo, Fulvia, D’Ippolito, Gianna Maria, Masieri, Simonetta, Matucci, Andrea, Mauro, Marina, Melchiorre, Antonietta, Menzella, Francesco, Micucci, Corrado, Mietta, Sabrina, Milanese, Manlio, Minetti, Stefano, Modiano, Ambra, Modica, Stella, Moinaghi, Marcello, Mondino, Michela, Munno, Giorgio, Muratore, Lionello, Murzilli, Francesco, Natoli, Rosalba, Nebiolo, Franco, Nettis, Eustachio, Olivieri, Elisa, Pannofno, Alessandro, Parpanesi, Mauro, Patella, Vincenzo, Petraroli, Angelica, Peveri, Silvia, Piantanida, Marta, Pietrafesa, Maria, Pinter, Elena, Pizzimenti, Stefano, Pompilio, Luana, Porcaro, Valeria, Prandini, Paolo, Pravettoni, Valerio, Pugliese, Salvatore, Quarta, Carlo, Quecchia, Cristina, Quercia, Oliviero, Quilleri, Roberto, Raie, Alberto, Randazzo, Salvatore, Ridolo, Erminia, Rolla, Giovanni, Romano, Antonino, Rota, Federica, Russello, Marina, Santucci, Annalisa, Savi, Eleonora, Scarantino, Giovanna, Scarpa, Sergio, Schiavino, Domenico, Sciacca, Angelo Rito, Serra, Paolo, Severino, Maurizio, Sirena, Alberto, Spadaro, Giuseppe, Spina, Francesca, Sugamiele, Mario, Taddeo, Giordano, Ventura, Maria Teresa, Testi, Sergio, Tombetti, Enrico, Tosoni, Cinzia, Triggiani, Massimo, Tripodi, Salvatore, Vallerani, Elisabetta, Vargiu, Arnoldo, Varricchio, Attilio, Zambito, Marcello, Zanforlin, Mario, and Zanoni, Giovanna

Subjects
Adult, Male, medicine.medical_specialty, Allergen immunotherapy, Sublingual, Adolescent, medicine.medical_treatment, ARIA guidelines, Desensitization, allergic rhinitis, survey data, Drug treatment, Young Adult, Patient satisfaction, Allergic, Immunologic, Allergic Rhinitis, Internal medicine, Administration, Patient compliance, Rhinitis, Seasonal, Female, Humans, Italy, Middle Aged, Patient Satisfaction, Rhinitis, Allergic, Skin Tests, Treatment Outcome, Data Collection, Medicine (all), medicine, In patient, Young adult, Rhiniti, Desensitization (medicine), High prevalence, Skin Test, Adult patients, business.industry, Settore MED/09 - MEDICINA INTERNA, General Medicine, Surgery, Public Health, business, Human
Abstract

Background: Allergic rhinitis (AR) has high prevalence and substantial socio-economic burden.Material/Methods: The study included 35 Italian Centers recruiting an overall number of 3383 adult patients with rhinitis (48% males, 52% females, mean age 29.1, range 18-45 years). For each patient, the attending physician had to fill in a standardized questionnaire, covering, in particular, some issues such as the ARIA classification of allergic rhinitis (AR), the results of skin prick test (SPT), the kind of treatment, the response to treatment, and the satisfaction with treatment.Results: Out of the 3383 patients with rhinitis, 2788 (82.4%) had AR: 311 (11.5%) had a mild intermittent, 229 (8.8%) a mild persistent, 636 (23.5%) a moderate-severe intermittent, and 1518 (56.1%) a moderate-severe persistent form. The most frequently used drugs were oral antihistamines (77.1%) and topical corticosteroids (60.8%). The response to treatment was judged as excellent in 12.2%, good in 41.3%, fair in 31.2%, poor in 14.5%, and very bad in 0.8% of subjects. The rate of treatment dissatisfaction was significantly higher in patients with moderate-to-severe AR than in patients with mild AR (p

Published
2014

29. Clinical presentation and management practice of systemic mastocytosis. A survey on 460 Italian patients

Author

Pieri, Lisa, primary, Bonadonna, Patrizia, additional, Elena, Chiara, additional, Papayannidis, Cristina, additional, Grifoni, Federica Irene, additional, Rondoni, Michela, additional, Girlanda, Stefania, additional, Mauro, Marina, additional, Magliacane, Diomira, additional, Elli, Elena Maria, additional, Iorno, Maria Loredana, additional, Almerigogna, Fabio, additional, Scarfì, Federica, additional, Salerno, Roberto, additional, Fanelli, Tiziana, additional, Gesullo, Francesca, additional, Corbizi Fattori, Giuditta, additional, Bonifacio, Massimiliano, additional, Perbellini, Omar, additional, Artuso, Anna, additional, Soverini, Simona, additional, De Benedittis, Caterina, additional, Muratori, Simona, additional, Pravettoni, Valerio, additional, Cova, Vittoria, additional, Cortellini, Gabriele, additional, Ciceri, Fabio, additional, Cortelezzi, Agostino, additional, Martinelli, Giovanni, additional, Triggiani, Massimo, additional, Merante, Serena, additional, Vannucchi, Alessandro Maria, additional, and Zanotti, Roberta, additional

Published
2016
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30. A Survey on Clinical and Biological Characteristic and Therapy Management of an Italian Series of 455 Adult Patients with Systemic Mastocytosis on Behalf of Italian Registry of Mastocytosis

Author

Pieri, Lisa, primary, Bonadonna, Patrizia, additional, Elena, Chiara, additional, Papayannidis, Cristina, additional, Grifoni, Federica Irene, additional, Rondoni, Michela, additional, Girlanda, Stefania, additional, Mauro, Marina, additional, Magliacane, Diomira, additional, Elli, Elena Maria, additional, Iorno, Maria Loredana, additional, Severino, Maurizio, additional, Almerigogna, Fabio, additional, Scarfì, Federica, additional, Bonifacio, Massimiliano, additional, Perbellini, Omar, additional, Artuso, Anna, additional, Soverini, Simona, additional, De Benedittis, Caterina, additional, Muratori, Simona, additional, Lunardon, Luisa, additional, Cova, Vittoria, additional, Cortellini, Gabriele, additional, Bosi, Alberto, additional, Cortelezzi, Agostino, additional, Martinelli, Giovanni, additional, Triggiani, Massimo, additional, Merante, Serena, additional, Vannucchi, Alessandro Maria, additional, and Zanotti, Roberta, additional

Published
2014
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31. Effective Ibuprofen Desensitization in a Patient with Myopericarditis.

Author

Cortellini, Gabriele, Lippolis, Domenico, Amati, Silvia, Piovaccari, Giancarlo, Cortellini, Fabio, and Ballardini, Giorgio

Subjects
*IBUPROFEN, *ALLERGY desensitization, *MYOCARDITIS, *NONSTEROIDAL anti-inflammatory agents, *RESPIRATORY diseases, *ANGIONEUROTIC edema
Abstract

To date, aspirin desensitization is employed with patients with nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbated respiratory diseases (NERD) or with aspirin or NSAIDs hypersensitive patients needing a stent procedure for coronary artery disease. On the other hand, few data exist regarding aspirin desensitization in other cardiological features and particularly we haven't data on different NSAIDs desensitization. Only for NERD patients we have data on ketorolac use. We report an efficacious desensitization procedure for ibuprofen in urticaria/angioedema patient with pericarditis and myocarditis associated. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Clinical Management of Patients with a History of Urticaria/Angioedema Induced by Multiple NSAIDs: An Expert Panel Review

Author

Asero, Riccardo, primary, Bavbek, Sevim, additional, Blanca, Miguel, additional, Blanca-Lopez, Natalia, additional, Cortellini, Gabriele, additional, Nizankowska-Mogilnicka, Ewa, additional, Quaratino, Donato, additional, Romano, Antonino, additional, Sanchez-Borges, Mario, additional, and Torres-Jaen, Maria Josè, additional

Published
2012
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34. Reply

Author

Passalacqua, Giovanni, primary, Severino, Maurizio G., additional, Cortellini, Gabriele, additional, Bonadonna, Patrizia, additional, Macchia, Donatella, additional, and Canonica, Walter G., additional

Published
2009
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37. Clinical Management of Patients with a History of Urticaria/Angioedema Induced by Multiple NSAIDs: An Expert Panel Review.

Author

asero, Riccardo, Bavbek, Sevim, Blanca, Miguel, Blanca-Lopez, Natalia, Cortellini, Gabriele, Nizankowska-Mogilnicka, Ewa, Quaratino, Donato, Romano, antonino, Sanchez-Borges, Mario, and Torres-Jaen, Maria Josè

Subjects
URTICARIA, MEDICAL history taking, ANGIONEUROTIC edema, NONSTEROIDAL anti-inflammatory agents, EXPERT evidence, PROVOCATION tests (Medicine), CYCLOOXYGENASES, PATIENTS
Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most frequent causes of drug-induced urticaria/angioedema worldwide. Recent review articles have classified patients experiencing NSAID-induced urticaria/angioedema into different categories, including single reactors, multiple reactors, and multiple reactors with underlying chronic urticaria. Each of these categories requires a different clinical approach. The present article, written by a panel of experts, reports the main recommendations for the practical clinical management of patients with a history of urticaria/angioedema induced by multiple NSAID based on current knowledge. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2013
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38. <italic>Vespa crabro</italic> immunotherapy versus <italic>Vespula</italic>-venom immunotherapy in <italic>Vespa crabro</italic> allergy: a comparison study in field re-stings.

Author

Macchia, Donatella, Cortellini, Gabriele, Mauro, Marina, Meucci, Elisa, Quercia, Oliviero, Manfredi, Mariangela, Massolo, Alessandro, Valentini, Maurizio, Severino, Maurizio, and Passalacqua, Giovanni

Subjects
*IMMUNOTHERAPY, *ALLERGIES
Abstract

Background: In ascertained allergic sensitization to Vespa crabro (VC) venom, the European guidelines still consider venom immunotherapy (VIT) with Vespula (VE) venom sufficient to achieve an adequate protection against VC. However, antigen 5 immunoblotting studies showed that a genuine sensitization to VC venom may exist. In such cases, a specific VC venom would be preferable for VIT treatment. Since in the last few years, VC venom extracts became available for diagnosis and desensitization, we assessed the efficacy and safety of VIT with a VC-VIT, compared to VE extract. Methods: Patients stung by VC, and carefully diagnosed for specific sensitization and indication to VIT underwent a 5-year course of immunotherapy with either VE or VC extracts. The severity of reactions at the first sting (pre-VIT) and after field re-stings (during VIT) were compared. Results: Eighty-three patients, treated with VE extract and 130 patients treated with VC extract completed the 5-year course of VIT. Only a fraction of those patients (43,8%) were field-re-stung by VC: 64 patients on VC VIT and 69 on VE VIT. In the VC VIT group, reactions at re-sting were: 50 negative, 12 large local reactions, 4 systemic reactions (Muller grade I). In this group the VC VIT efficacy was 93,8%. In the VE VIT treated group the reactions at VC re-sting were: 51 negative, 10 large local reactions and 9 systemic reactions (5 Muller I, 3 Mueller III, 1 Muller IV). In this group the overall efficacy of VIT was 87,0%. The difference in efficacy between the two groups was not statistically significant, as previously reported in literature. Nonetheless, field sting systemic reactions Muller III and IV were recorded only in those patients receiving VE VIT. Conclusion: This observation suggests that in patients with ascertained VC-induced allergic reactions a specific VC VIT, where available, would be more adequate, at least concerning the safety profile. [ABSTRACT FROM AUTHOR]

Published
2018
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