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14 results on '"Cortés Hidalgo, Andrea"'

1. Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Author

Kotsakis Ruehlmann, Anna, Sammallahti, Sara, Cortés Hidalgo, Andrea P., Bakulski, Kelly M., Binder, Elisabeth B., Campbell, Megan Loraine, Caramaschi, Doretta, Cecil, Charlotte A. M., Colicino, Elena, Cruceanu, Cristiana, Czamara, Darina, Dieckmann, Linda, Dou, John, Felix, Janine F., Frank, Josef, Håberg, Siri E., Herberth, Gunda, Hoang, Thanh T., Houtepen, Lotte C., Hüls, Anke, Koen, Nastassja, London, Stephanie J., Magnus, Maria C., Mancano, Giulia, Mulder, Rosa H., Page, Christian M., Räikkönen, Katri, Röder, Stefan, Schmidt, Rebecca J., Send, Tabea S., Sharp, Gemma, Stein, Dan J., Streit, Fabian, Tuhkanen, Johanna, Witt, Stephanie H., Zar, Heather J., Zenclussen, Ana C., Zhang, Yining, Zillich, Lea, Wright, Rosalind, Lahti, Jari, and Brunst, Kelly J.

Published
2023
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5. Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Author

Kotsakis Ruehlmann, Anna, Sammallahti, Sara, Cortés Hidalgo, Andrea P., Bakulski, Kelly M., Binder, Elisabeth B., Campbell, Megan Loraine, Caramaschi, Doretta, Cecil, Charlotte A. M., Colicino, Elena, Cruceanu, Cristiana, Czamara, Darina, Dieckmann, Linda, Dou, John, Felix, Janine F., Frank, Josef, Håberg, Siri E., Herberth, Gunda, Hoang, Thanh T., Houtepen, Lotte C., Hüls, Anke, Koen, Nastassja, London, Stephanie J., Magnus, Maria C., Mancano, Giulia, Mulder, Rosa H., Page, Christian M., Räikkönen, Katri, Röder, Stefan, Schmidt, Rebecca J., Send, Tabea S., Sharp, Gemma, Stein, Dan J., Streit, Fabian, Tuhkanen, Johanna, Witt, Stephanie H., Zar, Heather J., Zenclussen, Ana C., Zhang, Yining, Zillich, Lea, Wright, Rosalind, Lahti, Jari, and Brunst, Kelly J.

Abstract

Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biological mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysis included twelve non-overlapping cohorts from ten independent longitudinal studies (N= 5,496) within the international Pregnancy and Childhood Epigenetics consortium to examine maternal stressful life events during pregnancy and DNA methylation in cord blood. Children whose mothers reported higher levels of cumulative maternal stressful life events during pregnancy exhibited differential methylation of cg26579032 in ALKBH3. Stressor-specific domains of conflict with family/friends, abuse (physical, sexual, and emotional), and death of a close friend/relative were also associated with differential methylation of CpGs in APTX, MyD88, and both UHRF1and SDCCAG8, respectively; these genes are implicated in neurodegeneration, immune and cellular functions, regulation of global methylation levels, metabolism, and schizophrenia risk. Thus, differences in DNA methylation at these loci may provide novel insights into potential mechanisms of neurodevelopment in offspring.

Published
2024
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6. Early-Life Adversities and Neurocognitive Outcomes: An Epidemiological Study

Author

Cortés Hidalgo, Andrea, Tiemeier, Henning, van IJzendoorn, Marinus, Kranenburg, Marian, White, Tonya, and Child and Adolescent Psychiatry / Psychology

Abstract

This thesis is the compilation of studies that assessed stress and adversity using different approaches, and investigated the relation between adversities and early‑life stress with subsequent neurocognitive outcomes in the general population. This thesis also includes studies that addressed the role of protective factors, and the interplay between adversity and multiple protective factors in relation to brain morphology. Data from the population‑based Generation R Study, and the high‑risk Mannheim Study of Children at Risk were used in the studies presented here.

Published
2022

7. Early-Life Adversities and Neurocognitive Outcomes:An Epidemiological Study

Author

Cortés Hidalgo, Andrea and Cortés Hidalgo, Andrea

Abstract

This thesis is the compilation of studies that assessed stress and adversity using different approaches, and investigated the relation between adversities and early‑life stress with subsequent neurocognitive outcomes in the general population. This thesis also includes studies that addressed the role of protective factors, and the interplay between adversity and multiple protective factors in relation to brain morphology. Data from the population‑based Generation R Study, and the high‑risk Mannheim Study of Children at Risk were used in the studies presented here.

Published
2022

9. Frequent Bullying Involvement and Brain Morphology in Children

Author

Muetzel, Ryan, Mulder, Rosa, Lamballais Tessensohn, Sander, Cortés Hidalgo, Andrea, Jansen, Pauline, Guroglu, B, Vernooij, Meike, Hillegers, Manon, White, Tonya, El Marroun, Hanan, Tiemeier, Henning, Muetzel, Ryan, Mulder, Rosa, Lamballais Tessensohn, Sander, Cortés Hidalgo, Andrea, Jansen, Pauline, Guroglu, B, Vernooij, Meike, Hillegers, Manon, White, Tonya, El Marroun, Hanan, and Tiemeier, Henning

Published
2019

10. Maternal depression during pregnancy and cord blood DNA methylation: findings from the Avon Longitudinal Study of Parents and Children

Author

Viuff, AC, Sharp, GC, Rai, D, Henriksen, TB, Pedersen, LH, Kyng, KJ, Staunstrup, NH, Cortés Hidalgo, Andrea, Neumann, Alexander, Felix, Janine, Tiemeier, Henning, Jaddoe, Vincent, Relton, CL, Viuff, AC, Sharp, GC, Rai, D, Henriksen, TB, Pedersen, LH, Kyng, KJ, Staunstrup, NH, Cortés Hidalgo, Andrea, Neumann, Alexander, Felix, Janine, Tiemeier, Henning, Jaddoe, Vincent, and Relton, CL

Published
2018

11. The role of epigenetic modifications in neurodevelopmental disorders: A systematic review

Author

Dall'Aglio, Lorenza, Muka, Taulant, Cecil, Charlotte, Bramer, WM (Wichor), Verbiest, Michael, Nano, Jana, Cortés Hidalgo, Andrea, Franco Duran, OH, Tiemeier, Henning, Dall'Aglio, Lorenza, Muka, Taulant, Cecil, Charlotte, Bramer, WM (Wichor), Verbiest, Michael, Nano, Jana, Cortés Hidalgo, Andrea, Franco Duran, OH, and Tiemeier, Henning

Published
2018

14. Opciones terapéuticas frente a especies de Candida resistentes a las equinocandinas

Author

Cortés Hidalgo, Andrea Patricia, Roa Dueñas, Oscar Hernando, Méndez Fandiño, Yardany Rafael, Álvarez Moreno, Carlos Arturo, Cortés Hidalgo, Andrea Patricia, Roa Dueñas, Oscar Hernando, Méndez Fandiño, Yardany Rafael, and Álvarez Moreno, Carlos Arturo

Abstract

Introducción: La infección por levaduras del género Candida representa la causa más común de infecciones fúngicas invasivas. Su alta incidencia y la creciente resistencia frente a los azoles y, recientemente, a las equinocandinas ha generado la necesidad de buscar nuevas alternativas farmacológicas. Esta revisión presenta las principales alternativas farmacológicas en estudio frente a Candida resistente a equinocandinas. Métodos: Se buscó literatura referente al tema en las bases de datos Bireme, Clinical Key, Embase, Cochrane, Lilacs, Pubmed y Scopus. Se incluyeron 15 artículos en esta revisión. Resultados: Se exploran diferentes alternativas, incluyendo el aumento de dosis de las equinocandinas, su combinación con otros medicamentos y nuevos compuestos en estudio. Conclusión: A pesar de que las infecciones por Candida resistente a equinocandinas aún representan un desafío, dos alternativas farmacológicas se presentan como promisorias: la combinación con medicamentos existentes como el diclofenaco y nuevos compuestos que se encuentran actualmente en fase II de estudios clínicos.

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