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1. Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: toward a new paradigm

Author

Herrera, Fabián, Torres, Diego, Laborde, Ana, Jordán, Rosana, Tula, Lucas, Mañez, Noelia, Pereyra, María Laura, Suchowiercha, Nadia, Berruezo, Lorena, Gudiol, Carlota, Ibáñez, María Luz González, Eusebio, María José, Lambert, Sandra, Barcán, Laura, Rossi, Inés Roccia, Nicola, Federico, Pennini, Magdalena, Monge, Renata, Blanco, Miriam, Visús, Mariángeles, Reynaldi, Mariana, Carbone, Ruth, Pasterán, Fernando, Corso, Alejandra, Rapoport, Melina, and Carena, Alberto Angel

Published
2024
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3. WHO global research priorities for antimicrobial resistance in human health

Author

Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, D G Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Rudan, Igor, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, and Weezenbeek, Kitty Van

Published
2024
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7. Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

Author

Brooks, Abdullah, Corso, Alejandra, Davydov, Alexander, Maguire, Alison, Kiran, Anmol, Moiane, Benild, Beall, Bernard, Zhao, Chunjiang, Aanensen, David, Everett, Dean, Faccone, Diego, Foster-Nyarko, Ebenezer, Bojang, Ebrima, Egorova, Ekaterina, Voropaeva, Elena, Sampane-Donkor, Eric, Sadowy, Ewa, Nagaraj, Geetha, Mucavele, Helio, Belabbès, Houria, Elmdaghri, Naima, Verani, Jennifer, Keenan, Jeremy, Lees, John, N Nair Thulasee Bhai, Jyothish, Ndlangisa, Kedibone, Zerouali, Khalid, Bentley, Leon, Titov, Leonid, De Gouveia, Linda, Alaerts, Maaike, Ip, Margaret, de Cunto Brandileone, Maria Cristina, Hasanuzzaman, Md, Paragi, Metka, Nurse-Lucas, Michele, du Plessis, Mignon, Ali, Mushal, Croucher, Nicholas, Wolter, Nicole, Givon-Lavi, Noga, Porat, Nurit, Köseoglu Eser, Özgen, Ho, Pak-Leung, Eberechi Akpaka, Patrick, Gagetti, Paula, Tientcheu, Peggy-Estelle, Law, Pierra, Benisty, Rachel, Mostowy, Rafal, Malaker, Roly, Grassi Almeida, Samanta Cristine, Doiphode, Sanjay, Madhi, Shabir, Devi Sekaran, Shamala, Clarke, Stuart, Srifuengfung, Somporn, Nzenze, Susan, Kastrin, Tamara, Ochoa, Theresa, Hryniewicz, Waleria, Urban, Yulia, Lo, Stephanie W, Mellor, Kate, Cohen, Robert, Alonso, Alba Redin, Belman, Sophie, Kumar, Narender, Hawkins, Paulina A, Gladstone, Rebecca A, von Gottberg, Anne, Veeraraghavan, Balaji, Ravikumar, K L, Kandasamy, Rama, Pollard, Sir Andrew J, Saha, Samir K, Bigogo, Godfrey, Antonio, Martin, Kwambana-Adams, Brenda, Mirza, Shaper, Shakoor, Sadia, Nisar, Imran, Cornick, Jennifer E, Lehmann, Deborah, Ford, Rebecca L, Sigauque, Betuel, Turner, Paul, Moïsi, Jennifer, Obaro, Stephen K, Dagan, Ron, Diawara, Idrissa, Skoczyńska, Anna, Wang, Hui, Carter, Philip E, Klugman, Keith P, Rodgers, Gail, Breiman, Robert F, McGee, Lesley, Bentley, Stephen D, Muñoz-Almagro, Carmen, and Varon, Emmanuelle

Published
2022
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8. National Multicenter Study on the Prevalence of Carbapenemase-Producing Enterobacteriaceae in the Post-COVID-19 Era in Argentina: The RECAPT-AR Study.

Author

Echegorry, Mariano, Marchetti, Paulina, Sanchez, Cristian, Olivieri, Laura, Faccone, Diego, Martino, Florencia, Sarkis Badola, Tomas, Ceriana, Paola, Rapoport, Melina, Lucero, Celeste, Albornoz, Ezequiel, Corso, Alejandra, and Pasteran, Fernando

Subjects
MICROBIAL sensitivity tests, CARBAPENEMASE, KLEBSIELLA pneumoniae, COVID-19 pandemic, DRUG resistance in microorganisms
Abstract

The COVID-19 pandemic has exacerbated the global antimicrobial resistance (AMR) crisis. Consequently, it is more urgent than ever to prioritize AMR containment and support countries in improving the detection, characterization, and rapid response to emerging AMR threats. We conducted a prospective, multicenter study to assess the prevalence of carbapenemase-producing Enterobacterales in infectious processes in Argentina during the post-COVID-19 pandemic period and explore therapeutic alternatives for their treatment (RECAPT-AR study). Methods: A total of 182 hospitals participated by submitting Enterobacterales clinical isolates to the National Reference Laboratory (NRL) during the first three weeks of November 2021. Inclusion criteria were defined as an ertapenem MIC ≥ 0.5 mg/L, a zone diameter ≤ 22 mm. Carbapenemase genes and those coding for major extended-spectrum β-lactamases were molecularly characterized using multiplex PCR at the NRL. Antibiotic susceptibility testing followed international standards (CLSI and EUCAST). Results: The NRL analyzed 821 Enterobacterales isolates. Metallo-β-lactamase (MBL, 42.0%) and KPC (39.8%) accounted for 81.8% of carbapenemases, followed by OXA-163 (7.4%), a variant of OXA-48 with additional activity against extended-spectrum cephalosporins, and enzyme combinations (8.3%). These combinations included NDM plus KPC (3.4%), OXA-163 plus KPC (2.4%), and OXA-163 plus NDM (2.1%). Klebsiella pneumoniae was the main species recovered, representing 76% of the isolates. According to the carbapenemase classes or combinations, tigecycline exhibited a susceptibility range of 33–83%, fosfomycin 59–81%, colistin 27–78%, and amikacin 17–81%. Ceftazidime-avibactam (CZA) and imipenem-relebactam (IMR) showed 92% and 98% susceptibility against serine carbapenemases, respectively. Meanwhile, aztreonam-avibactam (AZA) exhibited 96–98% susceptibility against all carbapenemase classes. Conclusions: A new epidemiological landscape has emerged, characterized by the equivalent circulation of NDM and KPC. K. pneumoniae remains the primary species responsible for their dissemination. The co-production of carbapenemase combinations, particularly KPC plus NDM, was confirmed, mainly in K. pneumoniae. High activity was observed for AZA against MBLs and for CZA and IMR against KPC and OXA-163 carbapenemases. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Epidemiology of Bacteremia in Patients with Hematological Malignancies and Hematopoietic Stem Cell Transplantation and the Impact of Antibiotic Resistance on Mortality: Data from a Multicenter Study in Argentina.

Author

Herrera, Fabián, Torres, Diego, Laborde, Ana, Jordán, Rosana, Berruezo, Lorena, Roccia Rossi, Inés, Mañez, Noelia, Tula, Lucas, Pereyra, María Laura, Nenna, Andrea, Costantini, Patricia, Benso, José, González Ibañez, María Luz, Eusebio, María José, Baldoni, Nadia, Barcán, Laura Alicia, Lambert, Sandra, Luck, Martín, Pasterán, Fernando, and Corso, Alejandra

Subjects
HEMATOPOIETIC stem cell transplantation, STEM cell transplantation, MULTIDRUG resistance, HEMATOPOIETIC stem cells, HEMATOLOGIC malignancies, SEPTIC shock
Abstract

The epidemiology of bacteremia and the antibiotic resistance profile (ARP) of Gram-negative bacilli (GNB) in hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT) patients may differ according to geographic region. In addition, multidrug-resistant organisms (MDROs) may impact mortality. This is a prospective, observational, and multicenter study. The first episodes of bacteremia in adult patients with HM or HSCT were included. The risk factors for 30-day mortality were identified. One thousand two hundred and seventy-seven episodes were included (HM: 920; HSCT: 357). GNB were isolated in 60.3% of episodes, with Enterobacterales (46.9%) and P. aeruginosa (8.5%) being the most frequent. Gram-positive cocci were isolated in 41.9% of episodes, with coagulase-negative staphylococci (19.8%) and S. aureus (10.4%) being the most frequent. MDROs were isolated in 40.2% (24.4% GNB). The ARP of GNB in patients with HM vs. HSCT was cefepime: 36.8% vs. 45.7% (p = 0.026); piperacillin–tazobactam: 31.05% vs. 45.2% (p < 0.0001); carbapenems: 18.9% vs. 27.3% (p = 0.012); and aminoglycosides: 9.3% vs. 15.4% (p = 0.017), respectively. Overall mortality between patients with HM and HSCT was 17.5% vs. 17.6% (p = 0.951), respectively. The risk factors for mortality were relapsed and refractory underlying disease, corticosteroids use, respiratory source, septic shock, and GNB resistant to meropenem, while 7-day clinical response was a protective factor for survival. Bacteremia was frequently caused by GNB, with a large proportion of MDROs and a high level of antibiotic resistance, especially in patients with HSCT. Carbapenem-resistant GNB bacteremia was associated with a significant increase in mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Insights into Acinetobacter baumannii AMA205's Unprecedented Antibiotic Resistance.

Author

Traglia, German Matias, Pasteran, Fernando, Moheb, Samyar, Akhtar, Usman, Gonzalez, Sebastian, Maldonado, Carolina, Furtado, Nicholas, Mohamed, Ahmed, Escalante, Jenny, Tuttobene, Marisel R., Quillen, Araceli, Fontan, Claudia, Albornoz, Ezequiel, Corso, Alejandra, Bonomo, Robert A., Rao, Gauri G., Tolmasky, Marcelo E., and Ramirez, Maria Soledad

Subjects
HORIZONTAL gene transfer, DRUG resistance in bacteria, ANTIMICROBIAL stewardship, DRUG resistance in microorganisms, ACINETOBACTER baumannii, GENETIC code
Abstract

The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, Acinetobacter baumannii stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen. The A. baumannii AMA205 strain, belonging to sequence type ST79, was isolated from a COVID-19 patient in Argentina in 2021. This strain's antimicrobial resistance profile is notable as it harbors multiple resistance genes, some of which had not been previously described in this species. The AmpC family β-lactamase blaCMY-6, commonly found in Enterobacterales, had never been detected in A. baumannii before. Furthermore, this is the first ST79 strain known to carry the carbapenemase blaNDM-1 gene. Other acquired resistance genes include the carbapenemase blaOXA-23, further complicating treatment. Susceptibility testing revealed high resistance to most antibiotic families, including cefiderocol, with significant contributions from blaCMY-6 and blaNDM-1 genes to the cephalosporin and carbapenem resistance profiles. The A. baumannii AMA205 genome also contains genetic traits coding for 111 potential virulence factors, such as the iron-uptake system and biofilm-associated proteins. This study underscores A. baumannii's ability to acquire multiple resistance genes and highlights the need for alternative therapies and effective antimicrobial stewardship to control the spread of these highly resistant strains. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Comparison of available methods to evaluate cefiderocol susceptibility in Acinetobacter spp

Author

Pasteran, Fernando, primary, Wong, Olivia, additional, Mezcord, Vyanka, additional, Lopez, Christina, additional, Georgeos, Nardin, additional, Fua, Venjaminne, additional, Ozuna, Alonzo, additional, Ramlaoui, Dema, additional, Sánchez, Cristian, additional, Marchetti, Paulina, additional, Corso, Alejandra, additional, Tolmasky, Marcelo E., additional, Bonomo, Robert A., additional, and Ramirez, María Soledad, additional

Published
2024
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15. Seven-day antibiotic therapy for Enterobacterales bacteremia in high-risk neutropenic patients: Toward a new paradigm

Author

Herrera, Fabián, primary, Torres, Diego, additional, Laborde, Ana, additional, Jordán, Rosana, additional, Tula, Lucas, additional, Mañez, Noelia, additional, Pereyra, María Laura, additional, Suchorwiercha, Nadia, additional, Berruezo, Lorena, additional, Gudiol, Carlota, additional, Ibáñez, María Luz González, additional, Eusebio, María José, additional, Lambert, Sandra, additional, Barcán, Laura, additional, Rossi, Inés Roccia, additional, Nicola, Federico, additional, Peninni, Magdalena, additional, Monge, Renata, additional, Blanco, Miriam, additional, Visús, Mariángeles, additional, Reynaldi, Mariana, additional, Carbone, Ruth, additional, Pasterán, Fernando, additional, and Corso, Alejandra, additional

Published
2024
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16. KPC-2 allelic variants in Klebsiella pneumoniae isolates resistant to ceftazidime-avibactam from Argentina: bla KPC-80 , bla KPC-81 , bla KPC-96 and bla KPC-97

Author

Sanz, María Belén, primary, Pasteran, Fernando, additional, de Mendieta, Juan Manuel, additional, Brunetti, Florencia, additional, Albornoz, Ezequiel, additional, Rapoport, Melina, additional, Lucero, Celeste, additional, Errecalde, Laura, additional, Nuñez, Maria Rosa, additional, Monge, Renata, additional, Pennini, Magdalena, additional, Power, Pablo, additional, Corso, Alejandra, additional, and Gomez, Sonia A., additional

Published
2024
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18. MRSA dynamic circulation between the community and the hospital setting: New insights from a cohort study

Author

Barcudi, Danilo, Sosa, Ezequiel J., Lamberghini, Ricardo, Garnero, Analía, Tosoroni, Dario, Decca, Laura, Gonzalez, Liliana, Kuyuk, María A., Lopez, Teresa, Herrero, Ivana, Cortes, Paulo, Figueroa, Myrian, Egea, Ana L., Gagetti, Paula, Fernandez Do Porto, Darío A., Corso, Alejandra, Turjanski, Adrián G., Bocco, José L., and Sola, Claudia

Published
2020
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19. Novel allelic variants of blaOXA-48-likecarried on IncN2and IncC2plasmids isolated from clinical cases in Argentina: In vivoemergence of blaOXA-567

Author

de Mendieta, Juan Manuel, De Belder, Denise, Tijet, Nathalie, Ghiglione, Barbara, Melano, Roberto G., Rapoport, Melina, Power, Pablo, Di Bella, Adriana, Biondi, Estefanía, Pasterán, Fernando, Corso, Alejandra, and Gomez, Sonia A.

Abstract

•Carbapenem-resistant Escherichia coliST1196 and Klebsiella pneumoniaeST6838 were isolated from paediatric patients.•OXA-438 and OXA-567 were found to be novel variants derived from the OXA-48-like group of enzymes.•The new oxaenzymes were located in IncN2and IncC2conjugative plasmids.•The close genetic environment of blaOXA-438and blaOXA-567suggests a common origin.•blaOXA-567emerged during co-colonisation in vivowith blaOXA-163K. pneumoniae.

Published
2025
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20. WHO global research priorities for antimicrobial resistance in human health

Author

Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, Zignol, Matteo, Bertagnolio, Silvia, Dobreva, Zlatina, Centner, Chad M, Olaru, Ioana Diana, Donà, Daniele, Burzo, Stefano, Huttner, Benedikt D, Chaillon, Antoine, Gebreselassie, Nebiat, Wi, Teodora, Hasso-Agopsowicz, Mateusz, Allegranzi, Benedetta, Sati, Hatim, Ivanovska, Verica, Kothari, Kavita U, Balkhy, Hanan H, Cassini, Alessandro, Hamers, Raph L, Weezenbeek, Kitty Van, Aanensen, David, Alanio, Alexandre, Alastruey-Izquierdo, Ana, Alemayehu, Tinsae, Al-Hasan, Majdi, Allegaert, Karel, Al-Maani, Amal Saif, Al-Salman, Jameela, Alshukairi, Abeer Nizar, Amir, Afreenish, Applegate, Tanya, Araj, George F, Villalobos, Marlen Arce, Årdal, Christine, Ashiru-Oredope, Diane, Ashley, Elizabeth A, Babin, François-Xavier, Bachmann, Laura H, Bachmann, Till, Baker, Kate Susan, Balasegaram, Manica, Bamford, Colleen, Baquero, Fernando, Barcelona, Laura Isabel, Bassat, Quique, Bassetti, Matteo, Basu, Sulagna, Beardsley, Justin, Vásquez, Grey Benoit, Berkley, James A, Bhatnagar, Anuj K, Bielicki, Julia, Bines, Julie, Bongomin, Felix, Bonomo, Robert A, Bradley, John S, Bradshaw, Catriona, Brett, Ana, Brink, Adrian, Brown, Colin, Brown, Jeremy, Buising, Kirsty, Carson, Carolee, Carvalho, Anna Cristina, Castagnola, Elio, Cavaleri, Marco, Cecchini, Michele, Chabala, Chishala, Chaisson, Richard E, Chakrabarti, Arunaloke, Chandler, Clare, Chandy, Sujith John, Charani, Esmita, Chen, Lisa, Chiara, Francesca, Chowdhary, Anuradha, Chua, Arlene, Chuki, Pem, Chun, Doo Ryeon, Churchyard, Gavin, Cirillo, Daniela, Clack, Lauren, Coffin, Susan E, Cohn, Jennifer, Cole, Michelle, Conly, John, Cooper, Ben, Corso, Alejandra, Cosgrove, Sara E, Cox, Helen, Daley, Charles L, Darboe, Saffiatou, Darton, Tom, Davies, Gerry, de Egea, Viviana, Dedeić-Ljubović, Amela, Deeves, Miranda, Denkinger, Claudia, Dillon, Jo-Anne R, Dramowski, Angela, Eley, Brian, Roberta Esposito, Susanna Maria, Essack, Sabiha Y, Farida, Helmia, Farooqi, Joveria, Feasey, Nicholas, Ferreyra, Cecilia, Fifer, Helen, Finlayson, Heather, Frick, Mike, Gales, Ana Cristina, Galli, Luisa, Gandra, Sumanth, Gerber, Jeffrey S, Giske, Christian, Gordon, Bruce, Govender, Nelesh, Guessennd, Nathalie, Guindo, Ibrehima, Gurbanova, Elmira, Gwee, Amanda, Hagen, Ferry, Harbarth, Stephan, Haze, John, Heim, Jutta, Hendriksen, Rene, Heyderman, Robert Simon, Holt, Kathryn Elizabeth, Hönigl, Martin, Hook, Edward W, Hope, William, Hopkins, Heidi, Hughes, Gwenda, Ismail, Ghada, Issack, Mohammad Iqbal, Jacobs, Jan, Jasovský, Dušan, Jehan, Fyeza, Pearson, Antonieta Jimenez, Jones, Makoto, Joshi, Mohan P, Kapil, Arti, Kariuki, Samuel, Karkey, Abhilasha, Kearns, Gregory L, Keddy, Karen Helena, Khanna, Nina, Kitamura, Akiko, Kolho, Kaija-Leena, Kontoyiannis, Dimitrios P, Kotwani, Anita, Kozlov, Roman S, Kranzer, Katharina, Kularatne, Ranmini, Lahra, Monica M, Langford, Bradley J, Laniado-Laborin, Rafael, Larsson, Joakim, Lass-Flörl, Cornelia, Le Doare, Kirsty, Lee, Hyukmin, Lessa, Fernanda, Levin, Anna S, Limmathurotsakul, Direk, Lincopan, Nilton, Lo Vecchio, Andrea, Lodha, Rakesh, Loeb, Mark, Longtin, Yves, Lye, David Chien, Mahmud, Asif Mujtaba, Manaia, Célia, Manderson, Lenore, Mareković, Ivana, Marimuthu, Kalisvar, Martin, Irene, Mashe, Tapfumanei, Mei, Zeng, Meis, Jacques F, Lyra Tavares De Melo, Flávio Augusto, Mendelson, Marc, Miranda, Angelica Espinosa, Moore, David, Morel, Chantal, Moremi, Nyambura, Moro, Maria Luisa, Moussy, Francis, Mshana, Stephen, Mueller, Arno, Ndow, Francis J, Nicol, Mark, Nunn, Andrew, Obaro, Stephen, Obiero, Christina W, Okeke, Iruka N, Okomo, Uduak, Okwor, Tochi J, Oladele, Rita, Omulo, Sylvia, Ondoa, Pascale, Ortellado de Canese, Juana Medarda, Ostrosky-Zeichner, Luis, Padoveze, Maria Clara, Pai, Madhukar, Park, Benjamin, Parkhill, Julian, Parry, Christopher M, Peeling, Rosanna, Sobreira Vieira Peixe, Luísa Maria, Perovic, Olga, Pettigrew, Melinda M, Principi, Nicola, Pulcini, Céline, Puspandari, Nelly, Rawson, Timothy, Reddy, Denasha Lavanya, Reddy, Kessendri, Redner, Paulo, Rodríguez Tudela, Juan Luis, Rodríguez-Baño, Jesús, Van Katwyk, Susan Rogers, Roilides, Emmanuel, Rollier, Christine, Rollock, Leslie, Ronat, Jean-Baptiste, Ruppe, Etienne, Sadarangani, Manish, Salisbury, David, Salou, Mounerou, Samison, Luc Hervé, Sanguinetti, Maurizio, Sartelli, Massimo, Schellack, Natalie, Schouten, Jeroen, Schwaber, Mitchell J, Seni, Jeremiah, Senok, Abiola, Shafer, William M, Shakoor, Sadia, Sheppard, Donald, Shin, Jong-Hee, Sia, Sonia, Sievert, Dawn, Singh, Ishwar, Singla, Rupak, Skov, Robert Leo, Soge, Olusegun O, Sprute, Rosanne, Srinivasan, Arjun, Srinivasan, Subasree, Sundsfjord, Arnfinn, Tacconelli, Evelina, Tahseen, Sabira, Tangcharoensathien, Viroj, Tängdén, Thomas, Thursky, Karin, Thwaites, Guy, Tigulini de Souza Peral, Renata, Tong, Deborah, Tootla, Hafsah Deepa, Tsioutis, Constantinos, Turner, Katy M, Turner, Paul, Omar, Shaheed Vally, van de Sande, Wendy WJ, van den Hof, Susan, van Doorn, Rogier, Veeraraghavan, Balaji, Verweij, Paul, Wahyuningsih, Retno, Wang, Hui, Warris, Adilia, Weinstock, Hillard, Wesangula, Evelyn, Whiley, David, White, Peter J, Williams, Phoebe, Xiao, Yonghong, Moscoso, Martin Yagui, Yang, Hsu Li, Yoshida, Sachiyo, Yu, Yunsong, Żabicka, Dorota, and Zignol, Matteo

Abstract

The WHO research agenda for antimicrobial resistance (AMR) in human health has identified 40 research priorities to be addressed by the year 2030. These priorities focus on bacterial and fungal pathogens of crucial importance in addressing AMR, including drug-resistant pathogens causing tuberculosis. These research priorities encompass the entire people-centred journey, covering prevention, diagnosis, and treatment of antimicrobial-resistant infections, in addition to addressing the overarching knowledge gaps in AMR epidemiology, burden and drivers, policies and regulations, and awareness and education. The research priorities were identified through a multistage process, starting with a comprehensive scoping review of knowledge gaps, with expert inputs gathered through a survey and open call. The priority setting involved a rigorous modified Child Health and Nutrition Research Initiative approach, ensuring global representation and applicability of the findings. The ultimate goal of this research agenda is to encourage research and investment in the generation of evidence to better understand AMR dynamics and facilitate policy translation for reducing the burden and consequences of AMR.

Published
2024

21. Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

Author

Brooks, Abdullah W, Corso, Alejandra, Davydov, Alexander, Maguire, Alison, Pollard, Andrew, Kiran, Anmol, Skoczynska, Anna, Moiane, Benild, Beall, Bernard, Sigauque, Betuel, Aanensen, David, Lehmann, Deborah, Faccone, Diego, Foster-Nyarko, Ebenezer, Bojang, Ebrima, Egorova, Ekaterina, Voropaeva, Elena, Sampane-Donkor, Eric, Sadowy, Ewa, Bigogo, Godfrey, Mucavele, Helio, Belabbès, Houria, Diawara, Idrissa, Moïsi, Jennifer, Verani, Jennifer, Keenan, Jeremy, Nair Thulasee Bhai, Jyothish N, Ndlangisa, Kedibone M, Zerouali, Khalid, Ravikumar, K L, Titov, Leonid, De Gouveia, Linda, Alaerts, Maaike, Ip, Margaret, de Cunto Brandileone, Maria Cristina, Hasanuzzaman, Md, Paragi, Metka, Nurse-Lucas, Michele, Ali, Mushal, Elmdaghri, Naima, Croucher, Nicholas, Wolter, Nicole, Porat, Nurit, Eser, Özgen Köseoglu, Akpaka, Patrick E, Turner, Paul, Gagetti, Paula, Tientcheu, Peggy-Estelle, Carter, Philip E, Mostowy, Rafal, Kandasamy, Rama, Ford, Rebecca, Henderson, Rebecca, Malaker, Roly, Shakoor, Sadia, Grassi Almeida, Samanta Cristine, Saha, Samir K, Doiphode, Sanjay, Madhi, Shabir A, Devi Sekaran, Shamala, Srifuengfung, Somporn, Obaro, Stephen, Clarke, Stuart C, Nzenze, Susan A, Kastrin, Tamara, Ochoa, Theresa J, Balaji, Veeraraghavan, Hryniewicz, Waleria, Urban, Yulia, Lo, Stephanie W, Gladstone, Rebecca A, van Tonder, Andries J, Lees, John A, du Plessis, Mignon, Benisty, Rachel, Givon-Lavi, Noga, Hawkins, Paulina A, Cornick, Jennifer E, Kwambana-Adams, Brenda, Law, Pierra Y, Ho, Pak Leung, Antonio, Martin, Everett, Dean B, Dagan, Ron, von Gottberg, Anne, Klugman, Keith P, McGee, Lesley, Breiman, Robert F, and Bentley, Stephen D

Published
2019
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23. Geographical migration and fitness dynamics of Streptococcus pneumoniae.

Author

Belman, Sophie, Lefrancq, Noémie, Nzenze, Susan, Downs, Sarah, du Plessis, Mignon, Lo, Stephanie W., Corso, Alejandra, Gagetti, Paula, Brooks, Abdullah W., Hasanuzzaman, Md, Saha, Samir K., Saha, Senjuti, Davydov, Alexander, Titov, Leonid, Almeida, Samanta Cristine Grassi, Turner, Paul, Zhao, Chunjiang, Wang, Hui, Ip, Margaret, and Ho, Pak Leung

Abstract

Streptococcus pneumoniae is a leading cause of pneumonia and meningitis worldwide. Many different serotypes co-circulate endemically in any one location1,2. The extent and mechanisms of spread and vaccine-driven changes in fitness and antimicrobial resistance remain largely unquantified. Here using geolocated genome sequences from South Africa (n = 6,910, collected from 2000 to 2014), we developed models to reconstruct spread, pairing detailed human mobility data and genomic data. Separately, we estimated the population-level changes in fitness of strains that are included (vaccine type (VT)) and not included (non-vaccine type (NVT)) in pneumococcal conjugate vaccines, first implemented in South Africa in 2009. Differences in strain fitness between those that are and are not resistant to penicillin were also evaluated. We found that pneumococci only become homogenously mixed across South Africa after 50 years of transmission, with the slow spread driven by the focal nature of human mobility. Furthermore, in the years following vaccine implementation, the relative fitness of NVT compared with VT strains increased (relative risk of 1.68; 95% confidence interval of 1.59–1.77), with an increasing proportion of these NVT strains becoming resistant to penicillin. Our findings point to highly entrenched, slow transmission and indicate that initial vaccine-linked decreases in antimicrobial resistance may be transient.Mathematical modelling of 15 years of data from South Africa reveals the spread and vaccine-driven changes in fitness and antimicrobial resistance of Streptococcus pneumoniae. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Different evolution of S. aureus methicillin-resistant and methicillin-susceptible infections, Argentina

Author

Barcudi, Danilo, primary, Blasko, Enrique, additional, Gonzalez, María José, additional, Gagetti, Paula, additional, Lamberghini, Ricardo, additional, Garnero, Analía, additional, Sarkis, Claudia, additional, Faccone, Diego, additional, Lucero, Celeste, additional, Tosoroni, Dario, additional, Bocco, José L., additional, Corso, Alejandra, additional, Sola, Claudia, additional, Borda de Notario, Noemí, additional, Bermejo, Joaquín, additional, Farfan, Silvia Mariela, additional, Herrera, Patricia Carrizo, additional, Pallone, Elida, additional, Neumann, Gabriela, additional, Almuzara, Marisa N., additional, Dinerstein, Edith, additional, Gañete, Marcelo, additional, Togneri, Ana María, additional, Andres, Patricia, additional, Madsen, Elizabeth, additional, Aguila, Damian, additional, Perez, Jorgelina F., additional, Marchiaro, Patricia, additional, Orellana, Nora, additional, Castillo, Marcelo del, additional, Baroni, Maria Rosa, additional, Ezcurra, Gustavo Cesar, additional, Amalfi y Olivia Gear, Flavia, additional, Pereira, Nancy N., additional, Occello, María T., additional, García, Guillermo R., additional, Villegas, Josefina M., additional, Nizzo, Jorge Gonzalez, additional, Toffoli, Marcelo, additional, Granados, Gabriela, additional, Miranda, Maria R., additional, Pato, Ana M., additional, Achinelli, Fernando, additional, Almada, Gladys Margarita, additional, Sanchez, Ana Laura, additional, Gouts, Nuria Martina, additional, Vargas, Marcela, additional, Vega, Edgar Adan, additional, Vázquez, Cinthia, additional, Cano, Hortensia, additional, Cech, Norma Esther, additional, Rodriguez, Sergio, additional, Montanaro, Patricia, additional, Paredes, Marisa, additional, Garnero, Analía V., additional, Vilches, Viviana, additional, Quiros, Rodolfo, additional, Cané, Alejandro, additional, Uranga, Macarena, additional, González, Liliana, additional, Sanchez, Maria Lucrecia, additional, Tirao, Eugenia, additional, Machain, Mónica, additional, Fleitas, Hugo, additional, Blanca Mena, Norma Cudmani, additional, Lacono, Marisa Alejandra, additional, Núñez, María R., additional, Schinchirimini, María Martha, additional, Abate, Héctor, additional, García, Beatriz, additional, Benvenutti, María Luz, additional, Giordano, Laura, additional, Daniel Morales, Juan Carlos, additional, Vescina, Cecilia, additional, Di Bella, Adriana, additional, Taponier, Gabriela, additional, Daciuk, Lucia, additional, Degregoris, Gabriela, additional, Marianelli, Leonardo, additional, Lopez, Teresa, additional, Martins, Marcelo, additional, Wolff, Lidia, additional, Amador, Silvia G., additional, Segovia, Carina Evangelina, additional, Camisassa, Lilia, additional, Sosa, Luciana, additional, Flores, Sonia, additional, Rombola, Eduardo, additional, Gasparotto, Ana M., additional, Carrizo, Valeria Ocaña, additional, Greco, Carlos Quinteros, additional, Ballari, Estefania, additional, Minoli, Maria J., additional, Garutti, Alicia, additional, Cuniberti, Valentina, additional, Díaz, Elda, additional, Ciarlantini, Marcos, additional, Gonzalez, José, additional, Herrero, Ivana Lis, additional, Ocampo, Ivana, additional, Lopez, Adriana, additional, Cortes, Paulo R., additional, González, Patricia, additional, Calvari, Miriam, additional, Piersigilli, Andrea, additional, Maria Bilbao, Liliana Ether, additional, Blanco, Facundo, additional, Decca, Laura, additional, Fernando Riera, Claudio Manchado, additional, Beccereca, Graciela, additional, Vega, Daniela, additional, Canigia, Liliana Fernández, additional, Freuler, Cristina, additional, Della Latta, María Paula, additional, Mayer-Wolf, Micaela, additional, Yahni, Diego, additional, Smayevsky, Jorgelina, additional, Scocozza, Laura, additional, Diaz, María Susana, additional, Benegas, Liliana, additional, Pryluka, Daniel, additional, Manganello, Silvana, additional, Costa, Rosana, additional, Moyano, Mónica, additional, Zintgraff, Jonathan, additional, Garcia, Fabiana, additional, Figueroa, Miriam, additional, Landa, Mariana, additional, Bernardi, German, additional, Minguez, Angel, additional, Arriero, Graciela Alicia, additional, Díaz, María Silvia, additional, Mudrik, Maria Gabriela, additional, Panini, Nancy Veronica, additional, Cuello, Alejandra, additional, Gonzalez, Cristina Alicia, additional, Gerlach, Erica, additional, Kuo, Lein Hung, additional, Sparo, Mónica Delfina, additional, Gentile, Jorge Hector, additional, Henández, Claudia, additional, Ernst, Adriana Margarita, additional, Ensinck, Gabriela, additional, Alfonso, Claudia María, additional, Rodriguez Brieschke, Maria Teresa, additional, D´Alessandro, Daniela, additional, Vivaldo, María Silvana, additional, Malianni, Belen, additional, Berejnoi, Ana, additional, Falco, Adriana, additional, Andriani, María Ester, additional, Fernandez, Silvana, additional, Contreras, Karina, additional, Quiroga, Adriana, additional, Stafforini, Graciela María, additional, Aparicio, Maria Cristina, additional, Hernández, Claudia, additional, Pereda, Rosana, additional, Echave, Cecilia, additional, Arrieta, Maria Fernanda, additional, Musa, Daniela, additional, Zaloff Dakoff, Ana Maria, additional, and Corallo, Teresa Alicia, additional

Published
2023
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28. Co-integrate Col3m bla NDM-1 -harboring plasmids in clinical Providencia rettgeri isolates from Argentina

Author

De Belder, Denise, primary, Martino, Florencia, additional, Tijet, Nathalie, additional, Melano, Roberto G., additional, Faccone, Diego, additional, De Mendieta, Juan Manuel, additional, Rapoport, Melina, additional, Albornoz, Ezequiel, additional, Petroni, Alejandro, additional, Tuduri, Ezequiel, additional, Derdoy, Laura, additional, Cogut, Sandra, additional, Errecalde, Laura, additional, Pasteran, Fernando, additional, Corso, Alejandra, additional, and Gomez, Sonia A., additional

Published
2023
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29. New insights on mcr-1-harboring plasmids from human clinical Escherichia coli isolates.

Author

Martino, Florencia, Petroni, Alejandro, Menocal, María Alejandra, Corso, Alejandra, Melano, Roberto, and Faccone, Diego

Subjects
PLASMIDS, ESCHERICHIA coli, CARBAPENEM-resistant bacteria, KLEBSIELLA pneumoniae, GENETIC variation, GRAM-negative bacteria
Abstract

Mobile colistin resistance (mcr) genes were described recently in Gram-negative bacteria including carbapenem-resistant Enterobacterales. There are ten mcr genes described in different Gram-negative bacteria, however, Escherichia coli harboring mcr-1 gene is by far the most frequent combination. In Argentina, mcr-1 gene was characterized only on plasmids belonging to IncI2 group. The aim of this work was to get new insights of mcr-1-harboring plasmids from E. coli. Eight E. coli isolates from a larger collection of 192 clinical E. coli isolates carrying the mcr-1 gene were sequenced using next generation technologies. Three isolates belonged to ST131 high-risk clone, and five to single ST, ST38, ST46, ST226, ST224, and ST405. Eight diverse mcr-1-harboring plasmids were analyzed: IncI2 (1), IncX4 (3), IncHI2/2A (3) and a hybrid IncFIA/HI1A/HI1B (1) plasmid. Plasmids belonging to the IncI2 (n = 1) and IncX4 (n = 3) groups showed high similarity with previously described plasmids. Two IncHI2/HI2A plasmids, showed high identity between them, while the third, showed several differences including additional resistance genes like tet(A) and floR. One IncFIA/H1A/H1B hybrid plasmid was characterized, highly similar to pSRC27-H, a prototype plasmid lacking mcr genes. mcr-1.5 variant was found in four plasmids with three different Inc groups: IncI2, IncHI2/HI2A and the hybrid FIA/HI1A/HI1B plasmid. mcr-1.5 variant is almost exclusively described in our country and with a high frequency. In addition, six E. coli isolates carried three allelic variants codifying for CTX-M-type extended-spectrum-β-lactamases: blaCTX-M-2 (3), blaCTX-M-65 (2), and blaCTX-M-14 (1). It is the first description of mcr-1 harboring plasmids different to IncI2 group in our country. These results represents new insights about mcr-1 harboring plasmids recovered from E. coli human samples from Argentina, showing different plasmid backbones and resistance gene combinations. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Novel Metallo-β-Lactamase blaCVI-1 Isolated from a Chromobaterium violaceum Clinical Strain Resistant to Colistin

Author

Gomez, Sonia A., primary, Sanz, María Belén, additional, Rapoport, Melina, additional, Sucin, Graciela, additional, Corallo, Teresa A., additional, Poklepovich, Tomás, additional, Campos, Josefina, additional, Ceriana, Paola, additional, de Mendieta, Juan Manuel, additional, Prieto, Mónica, additional, Pasteran, Fernando, additional, and Corso, Alejandra, additional

Published
2023
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33. Emergence of Hyper-Epidemic Clones of Enterobacterales Clinical Isolates Co-Producing KPC and Metallo-Beta-Lactamases during the COVID-19 Pandemic

Author

Faccone, Diego, primary, Gomez, Sonia A., additional, de Mendieta, Juan Manuel, additional, Sanz, María Belén, additional, Echegorry, Mariano, additional, Albornoz, Ezequiel, additional, Lucero, Celeste, additional, Ceriana, Paola, additional, Menocal, Alejandra, additional, Martino, Florencia, additional, De Belder, Denise, additional, Corso, Alejandra, additional, and Pasterán, Fernando, additional

Published
2023
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34. Genomic Comparative Analysis of Two Multi-Drug Resistance (MDR) Acinetobacter baumannii Clinical Strains Assigned to International Clonal Lineage II Recovered Pre- and Post-COVID-19 Pandemic

Author

Traglia, German Matias, primary, Pasteran, Fernando, additional, Escalante, Jenny, additional, Nishimura, Brent, additional, Tuttobene, Marisel R., additional, Subils, Tomás, additional, Nuñez, Maria Rosa, additional, Rivollier, María Gabriela, additional, Corso, Alejandra, additional, Tolmasky, Marcelo E., additional, and Ramirez, Maria Soledad, additional

Published
2023
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35. Development of a Clinical Score to Stratify the Risk for Carbapenem-Resistant Enterobacterales Bacteremia in Patients with Cancer and Hematopoietic Stem Cell Transplantation

Author

Herrera, Fabián, primary, Torres, Diego, additional, Laborde, Ana, additional, Berruezo, Lorena, additional, Jordán, Rosana, additional, Rossi, Inés Roccia, additional, Valledor, Alejandra, additional, Costantini, Patricia, additional, Dictar, Miguel, additional, Nenna, Andrea, additional, Pereyra, María Laura, additional, Lambert, Sandra, additional, Benso, José, additional, Poletta, Fernando, additional, Gonzalez Ibañez, María Luz, additional, Baldoni, Nadia, additional, Eusebio, María José, additional, Lovano, Fiorella, additional, Barcán, Laura, additional, Luck, Martín, additional, Racioppi, Agustina, additional, Tula, Lucas, additional, Pasterán, Fernando, additional, Corso, Alejandra, additional, Rapoport, Melina, additional, Nicola, Federico, additional, García Damiano, María Cristina, additional, Carbone, Ruth, additional, Monge, Renata, additional, Reynaldi, Mariana, additional, Greco, Graciela, additional, Bronzi, Marcelo, additional, Valle, Sandra, additional, Chaves, María Laura, additional, Vilches, Viviana, additional, Blanco, Miriam, additional, and Carena, Alberto Ángel, additional

Published
2023
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37. Emergence of KPC-31, a KPC-3 Variant Associated with Ceftazidime-Avibactam Resistance, in an Extensively Drug-Resistant ST235 Pseudomonas aeruginosa Clinical Isolate

Author

Faccone, Diego, primary, de Mendieta, Juan M., additional, Albornoz, Ezequiel, additional, Chavez, Magali, additional, Genero, Fabiana, additional, Echegorry, Mariano, additional, Ceriana, Paola, additional, Mora, Andrea, additional, Seah, Christine, additional, Corso, Alejandra, additional, Melano, Roberto G., additional, and Pasteran, Fernando, additional

Published
2022
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38. Increased Detection of Carbapenemase-Producing Enterobacterales Bacteria in Latin America and the Caribbean during the COVID-19 Pandemic

Author

Thomas, Genara Romero, primary, Corso, Alejandra, additional, Pasterán, Fernando, additional, Shal, Justina, additional, Sosa, Aldo, additional, Pillonetto, Marcelo, additional, de Souza Peral, Renata Tigulini, additional, Hormazábal, Juan Carlos, additional, Araya, Pamela, additional, Saavedra, Sandra Yamile, additional, Ovalle, Mariá Victoria, additional, Jiménez Pearson, María Antonieta, additional, Chacón, Grettel Chanto, additional, Carbon, Eric, additional, Mazariegos Herrera, Carmen Julia, additional, Velásquez, Selene del Carmen González, additional, Satan-Salazar, Carolina, additional, Villavicencio, Fernando, additional, Touchet, Nancy Melgarejo, additional, Busignani, Sofía, additional, Mayta-Barrios, Maritza, additional, Ramírez-Illescas, Juan, additional, Vega, Mariana López, additional, Mogdasy, Cristina, additional, Rosas, Verónica, additional, Salgado, Nuris, additional, Quiroz, Rodolfo, additional, El-Omeiri, Nathalie, additional, Galas, Marcelo Fabián, additional, Ramón-Pardo, Pilar, additional, and Melano, Roberto Gustavo, additional

Published
2022
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40. Emergence of optrA-mediated linezolid resistance in clinical isolates of Enterococcus faecalisfrom Argentina

Author

Gagetti, Paula, Faccone, Diego, Ceriana, Paola, Lucero, Celeste, Menocal, Alejandra, Argentina, Grupo LRE, and Corso, Alejandra

Abstract

•First report of optrA-mediated linezolid-resistant clinical isolates inArgentina.•optrAgene was detected in multidrug-resistant Enterococcus faecalisisolates.•E. faecalisisolates belonged to different lineages, highlighting the high diversity among them.•Most of the isolates carried the optrAgene in plasmids.•Importance of the antimicrobial surveillance ofEnterococcusspp. using the One Health strategy.

Published
2023
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41. Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

Author

Lo, Stephanie W, primary, Mellor, Kate, additional, Cohen, Robert, additional, Alonso, Alba Redin, additional, Belman, Sophie, additional, Kumar, Narender, additional, Hawkins, Paulina A, additional, Gladstone, Rebecca A, additional, von Gottberg, Anne, additional, Veeraraghavan, Balaji, additional, Ravikumar, K L, additional, Kandasamy, Rama, additional, Pollard, Sir Andrew J, additional, Saha, Samir K, additional, Bigogo, Godfrey, additional, Antonio, Martin, additional, Kwambana-Adams, Brenda, additional, Mirza, Shaper, additional, Shakoor, Sadia, additional, Nisar, Imran, additional, Cornick, Jennifer E, additional, Lehmann, Deborah, additional, Ford, Rebecca L, additional, Sigauque, Betuel, additional, Turner, Paul, additional, Moïsi, Jennifer, additional, Obaro, Stephen K, additional, Dagan, Ron, additional, Diawara, Idrissa, additional, Skoczyńska, Anna, additional, Wang, Hui, additional, Carter, Philip E, additional, Klugman, Keith P, additional, Rodgers, Gail, additional, Breiman, Robert F, additional, McGee, Lesley, additional, Bentley, Stephen D, additional, Muñoz-Almagro, Carmen, additional, Varon, Emmanuelle, additional, Brooks, Abdullah, additional, Corso, Alejandra, additional, Davydov, Alexander, additional, Maguire, Alison, additional, Kiran, Anmol, additional, Moiane, Benild, additional, Beall, Bernard, additional, Zhao, Chunjiang, additional, Aanensen, David, additional, Everett, Dean, additional, Faccone, Diego, additional, Foster-Nyarko, Ebenezer, additional, Bojang, Ebrima, additional, Egorova, Ekaterina, additional, Voropaeva, Elena, additional, Sampane-Donkor, Eric, additional, Sadowy, Ewa, additional, Nagaraj, Geetha, additional, Mucavele, Helio, additional, Belabbès, Houria, additional, Elmdaghri, Naima, additional, Verani, Jennifer, additional, Keenan, Jeremy, additional, Lees, John, additional, N Nair Thulasee Bhai, Jyothish, additional, Ndlangisa, Kedibone, additional, Zerouali, Khalid, additional, Bentley, Leon, additional, Titov, Leonid, additional, De Gouveia, Linda, additional, Alaerts, Maaike, additional, Ip, Margaret, additional, de Cunto Brandileone, Maria Cristina, additional, Hasanuzzaman, Md, additional, Paragi, Metka, additional, Nurse-Lucas, Michele, additional, du Plessis, Mignon, additional, Ali, Mushal, additional, Croucher, Nicholas, additional, Wolter, Nicole, additional, Givon-Lavi, Noga, additional, Porat, Nurit, additional, Köseoglu Eser, Özgen, additional, Ho, Pak-Leung, additional, Eberechi Akpaka, Patrick, additional, Gagetti, Paula, additional, Tientcheu, Peggy-Estelle, additional, Law, Pierra, additional, Benisty, Rachel, additional, Mostowy, Rafal, additional, Malaker, Roly, additional, Grassi Almeida, Samanta Cristine, additional, Doiphode, Sanjay, additional, Madhi, Shabir, additional, Devi Sekaran, Shamala, additional, Clarke, Stuart, additional, Srifuengfung, Somporn, additional, Nzenze, Susan, additional, Kastrin, Tamara, additional, Ochoa, Theresa, additional, Hryniewicz, Waleria, additional, and Urban, Yulia, additional

Published
2022
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43. Novel Metallo-β-Lactamase bla CVI-1 Isolated from a Chromobaterium violaceum Clinical Strain Resistant to Colistin.

Author

Gomez, Sonia A., Sanz, María Belén, Rapoport, Melina, Sucin, Graciela, Corallo, Teresa A., Poklepovich, Tomás, Campos, Josefina, Ceriana, Paola, de Mendieta, Juan Manuel, Prieto, Mónica, Pasteran, Fernando, and Corso, Alejandra

Subjects
COLISTIN, NUCLEOTIDE sequencing, CHROMOBACTERIUM violaceum, HOSPITAL care of children, SEQUENCE analysis
Abstract

Objective: We aimed to describe a colistin (COL)-resistant (R) Chromobacterium violaceum (Cvi) isolate from a septic patient in Argentina expressing a previously unknown gene, blaCVI-1. Methods: In 2019, a 12 year old child was injured with a thorn in a lagoon. The child was hospitalized due to sepsis and multiple abscesses. Cvi was isolated from skin and soft tissue and tracheal aspirate. The patient was successfully treated with imipenem (IMI) plus amikacin. Antimicrobial susceptibility was assessed by disk diffusion, broth microdilution, and the E-test. Carbapenemase activity was assayed by double-disk synergy and microbiological tests. Resistance, virulence, and additional gene searches were performed by in silico analysis of sequences obtained by whole-genome sequencing (WGS). A maximum likelihood phylogenetic tree was built with public Cvi genomes. Results: R was seen for IMI and COL. Expression of a metallo-β-lactamase was confirmed. Genome analysis revealed blaCVI-1, a subclass B2 metallo-β-lactamase with 62.66% ID with CphA from A. hydrophila (WP081086394). R to COL could be attributed to the arnC and arnT genes. Virulence factors required for invasion and toxicity were also found. No plasmids were detected. The phylogeny tree showed two main clades with geographical distinction, and the isolate studied here stands alone in a branch closely related to two clinical isolates from the USA. Conclusions: This is the second report of infection by Cvi in Argentina. This pathogen carried a new gene, blaCVI-1, a metallo-β-lactamase that can be detected by routine methods. Prompt suspicion of C. violaceum infection is crucial to treating this rare pathogen rapidly and properly. [ABSTRACT FROM AUTHOR]

Published
2023
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45. Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: Role of Iron Transport

Author

Le, Casin, primary, Pimentel, Camila, additional, Pasteran, Fernando, additional, Tuttobene, Marisel R., additional, Subils, Tomás, additional, Escalante, Jenny, additional, Nishimura, Brent, additional, Arriaga, Susana, additional, Carranza, Aimee, additional, Mezcord, Vyanka, additional, Vila, Alejandro J., additional, Corso, Alejandra, additional, Actis, Luis A., additional, Tolmasky, Marcelo E., additional, Bonomo, Robert A., additional, and Ramírez, Maria Soledad, additional

Published
2022
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47. International links between Streptococcus pneumoniae vaccine serotype 4 sequence type (ST) 801 in Northern European shipyard outbreaks of invasive pneumococcal disease

Author

Gladstone, R.A., primary, Siira, L., additional, Brynildsrud, O.B., additional, Vestrheim, D.F., additional, Turner, P., additional, Clarke, S.C., additional, Srifuengfung, S., additional, Ford, R., additional, Lehmann, D., additional, Egorova, E., additional, Voropaeva, E., additional, Haraldsson, G., additional, Kristinsson, K.G., additional, McGee, L., additional, Breiman, R.F., additional, Bentley, S.D., additional, Sheppard, C.L., additional, Fry, N.K., additional, Corander, J., additional, Toropainen, M, additional, Steens, A., additional, Akpaka, Patrick E, additional, Ampofo, Krow, additional, Antonio, Martin, additional, Balaji, Veeraraghavan, additional, Beall, Bernard W., additional, Belabbès, Houria, additional, Benisty, Rachel, additional, Bigogo, Godfrey, additional, Brooks, Abdullah W, additional, Carter, Philip E., additional, Cornick, Jennifer E., additional, Corso, Alejandra, additional, Cristina de Cunto Brandileone, Maria, additional, Cristine Grassi Almeida, Samanta, additional, Croucher, Nicholas J., additional, Dagan, Ron, additional, Davydov, Alexander, additional, Diawara, Idrissa, additional, Doiphode, Sanjay, additional, du Plessis, Mignon, additional, Elmdaghri, Naima, additional, Köseoglu Eser, Özgen, additional, Everett, Dean B., additional, Faccone, Diego, additional, Gagetti, Paula, additional, Givon-Lavi, Noga, additional, Hasanuzzaman, Md, additional, Hawkins, Paulina A., additional, Hryniewicz, Waleria, additional, Hulten, Kristina G., additional, Ip, Margaret, additional, Kapusta, Aurelie, additional, Kandasamy, Rama, additional, Kastrin, Tamara, additional, Keenan, Jeremy, additional, Klugman, Keith P., additional, Kwambana-Adams, Brenda, additional, Law, Pierra Y., additional, Lees, John A, additional, Leung Ho, Pak, additional, Li, Yuan, additional, Lo, Stephanie W., additional, Ochoa, Theresa J., additional, Madhi, Shabir A., additional, Metcalf, Benjamin J, additional, Moïsi, Jennifer, additional, Mucavele Fundação Manhiça, Helio, additional, Ndlangisa, Kedibone M., additional, Nurse-Lucas, Michele, additional, Nzenze, Susan A., additional, Obaro, Stephen K, additional, Paragi, Metka, additional, Pollard, Andrew J, additional, Ravikumar, KL., additional, Sadowy, Ewa, additional, Saha, Samir K., additional, Sampane-Donkor, Eric, additional, Devi Sekaran, Shamala, additional, Shakoor, Sadia, additional, Shrestha, Shrijana, additional, Sigauque, Betuel, additional, Skoczynska, Anna, additional, Soo ko, Kwan, additional, Tientcheu, Peggy-Estelle, additional, Titov, Leonid, additional, Urban, Yulia, additional, Verani, Jennifer, additional, van Tonder, Andries J., additional, von Gottberg, Anne, additional, and Wolter, Nicole, additional

Published
2022
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48. Invasive Streptococcus pneumoniae isolates from pediatric population in Argentina for the period 2006–2019. Temporal progression of serotypes distribution and antibiotic resistance

Author

Zintgraff, Jonathan, primary, Gagetti, Paula, additional, Napoli, Daniela, additional, Sanchez Eluchans, Nahuel, additional, Irazu, Lucia, additional, Moscoloni, Maria, additional, Regueira, Mabel, additional, Lara, Claudia S., additional, and Corso, Alejandra, additional

Published
2022
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50. 945. Bacteremia in Patients with Solid Tumors: Epidemiology, Clinical Features and Risk Factors for Mortality. Results from a Multicenter Study in Argentina

Author

Costantini, Patricia E, primary, Torres, Diego, additional, Dictar, Miguel, additional, Nenna, Andrea, additional, Valledor, Alejandra, additional, Jordán, Rosana, additional, Laborde, Ana, additional, Lambert, Sandra, additional, Benso, José, additional, Carena, Alberto, additional, Luck, Martín, additional, Racioppi, Agustina, additional, Barcan, Laura, additional, Eusebio, María José, additional, Gonzalez Ibañez, María Luz, additional, Tula, Lucas, additional, Pasteran, Fernando, additional, Corso, Alejandra, additional, Rapoport, Melina, additional, Bronzi, Marcelo, additional, Nicola, Federico, additional, Valle, Sandra, additional, Chaves, María Laura, additional, Greco, Graciela, additional, Monge, Renata, additional, Damiano, María Cristina García, additional, Blanco, Miriam, additional, and Herrera, Fabián, additional

Published
2021
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