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304 results on '"Corsini, Iuri"'

6. Lung UltrasouNd Guided surfactant therapy in preterm infants: an international multicenter randomized control trial (LUNG study)

Author

Corsini, Iuri, Rodriguez-Fanjul, Javier, Raimondi, Francesco, Boni, Luca, Berardi, Alberto, Aldecoa-Bilbao, Victoria, Alonso-Ojembarrena, Almudena, Ancora, Gina, Aversa, Salvatore, Beghini, Renzo, Meseguer, Nerea Bilbao, Capasso, Letizia, Chesi, Francesca, Ciarcià, Martina, Concheiro, Ana, Corvaglia, Luigi, Ficial, Benjamim, Filippi, Luca, Carballal, Jesus Fuentes, Fusco, Monica, Gatto, Sara, Ginovart, Gemma, Gregorio-Hernández, Rebeca, Lista, Gianluca, Sánchez-Luna, Manuel, Martini, Silvia, Massenzi, Luca, Miselli, Francesca, Mercadante, Domenica, Mosca, Fabio, Palacio, Marta Teresa, Perri, Alessandro, Piano, Francesca, Prieto, Marcelino Pumarada, Fernandez, Lorena Rodeno, Risso, Francesco Maria, Savoia, Marilena, Staffler, Alex, Vento, Giovanni, and Dani, Carlo

Published
2023
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8. Deep learning in the ultrasound evaluation of neonatal respiratory status

Author

Gravina, Michela, Gragnaniello, Diego, Verdoliva, Luisa, Poggi, Giovanni, Corsini, Iuri, Dani, Carlo, Meneghin, Fabio, Lista, Gianluca, Aversa, Salvatore, Raimondi, Francesco, Migliaro, Fiorella, and Sansone, Carlo

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition
Abstract

Lung ultrasound imaging is reaching growing interest from the scientific community. On one side, thanks to its harmlessness and high descriptive power, this kind of diagnostic imaging has been largely adopted in sensitive applications, like the diagnosis and follow-up of preterm newborns in neonatal intensive care units. On the other side, state-of-the-art image analysis and pattern recognition approaches have recently proven their ability to fully exploit the rich information contained in these data, making them attractive for the research community. In this work, we present a thorough analysis of recent deep learning networks and training strategies carried out on a vast and challenging multicenter dataset comprising 87 patients with different diseases and gestational ages. These approaches are employed to assess the lung respiratory status from ultrasound images and are evaluated against a reference marker. The conducted analysis sheds some light on this problem by showing the critical points that can mislead the training procedure and proposes some adaptations to the specific data and task. The achieved results sensibly outperform those obtained by a previous work, which is based on textural features, and narrow the gap with the visual score predicted by the human experts., Comment: 7 pages

Published
2020

11. Neonatal lung ultrasound and surfactant administration: a pragmatic, multicenter study

Author

Raimondi, Francesco, Migliaro, Fiorella, Corsini, Iuri, Meneghin, Fabio, Pierri, Luca, Salomè, Serena, Perri, Alessandro, Aversa, Salvatore, Nobile, Stefano, Lama, Silvia, Varano, Silvia, Savoia, Marilena, Gatto, Sara, Leonardi, Valentina, Capasso, Letizia, Carnielli, Virgilio Paolo, Mosca, Fabio, Dani, Carlo, Vento, Giovanni, Dolce, Pasquale, and Lista, Gianluca

Published
2021
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12. Inspired oxygen fraction thresholds to accurately predict surfactant administration in neonatal RDS is gestational age strata: A pragmatic, multi‐center study.

Author

Raimondi, Francesco, Dolce, Pasquale, Veropalumbo, Claudio, Sierchio, Enrico, Corsini, Iuri, Meneghin, Fabio, Lama, Silvia, Raschetti, Roberto, Varano, Silvia, Perri, Alessandro, Bonadies, Luca, Ojembarrena, Almudena Alonso, Fanjul, Javier Rodriguez, Hernandez, Rebeca Gregorio, Fernandez, Lorena Rodeño, Davis, Peter G., Capasso, Letizia, Migliaro, Fiorella, Salomè, Serena, and Pierri, Luca

Published
2024
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13. Tissue‐Tracking Mitral Annular Displacement in Neonates

Author

Ficial, Benjamim, primary, Benfari, Giovanni, additional, Bonafiglia, Elena, additional, Clemente, Maria, additional, Cappelleri, Alessia, additional, Flore, Alice Iride, additional, Petoello, Enrico, additional, Ciarcià, Martina, additional, Nogara, Silvia, additional, Milocchi, Carlotta, additional, Dani, Carlo, additional, Ribichini, Flavio Luciano, additional, Gottin, Leonardo, additional, and Corsini, Iuri, additional

Published
2023
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14. Tissue‐Tracking Mitral Annular Displacement in Neonates: A Novel Index of Left Ventricular Systolic Function.

Author

Ficial, Benjamim, Benfari, Giovanni, Bonafiglia, Elena, Clemente, Maria, Cappelleri, Alessia, Flore, Alice Iride, Petoello, Enrico, Ciarcià, Martina, Nogara, Silvia, Milocchi, Carlotta, Dani, Carlo, Ribichini, Flavio Luciano, Gottin, Leonardo, and Corsini, Iuri

Subjects
GLOBAL longitudinal strain, LEFT heart ventricle, NEWBORN infants, INTRACLASS correlation, RECEIVER operating characteristic curves, VENTRICULAR ejection fraction
Abstract

Objectives: To assess the feasibility, accuracy, and reproducibility of tissue‐tracking mitral annular displacement (TMAD) compared with other measures of left ventricular systolic function in healthy preterm and term neonates in the transitional period. Methods: This was a prospective observational study. Two echocardiograms were performed at 24 and 48 hours of life. TMAD, shortening fraction (SF), ejection fraction (EF), s′, and global longitudinal strain (GLS) were measured offline. Accuracy to detect impaired GLS was tested by ROC curve analysis. DeLong test was used to compare AUCs. Intra and interobserver reproducibility of the off‐line analysis was calculated. Results: Mean ± SD gestational age and weight were 34.2 ± 3.8 weeks and 2162 ± 833 g, respectively. TMAD was feasible in 168/180 scans (93%). At 24 hours the AUC (95% CI) of SF, EF, s′, and TMAD (%) was 0.51 (0.36–0.67), 0.68 (0.54–0.82), 0.63 (0.49–0.77), and 0.89 (0.79–0.99) respectively. At 48 hours the AUC (95% CI) of SF, EF, s′, and TMAD (%) was 0.64 (0.51–0.77), 0.59 (0.37–0.80), 0.70 (0.54–0.86), and 0.96 (0.91–1.00), respectively. The AUC of TMAD was superior to the AUC of SF, EF, s′, at both timepoints (P <.02). Intraclass correlation coefficients (95% CI) of intra and interobserver reproducibility of TMAD were 0.97 (0.95–0.99) and 0.94 (0.88–0.97), respectively. Conclusion: TMAD showed improved accuracy and optimal reproducibility in neonates in the first 48 hours of life. [ABSTRACT FROM AUTHOR]

Published
2024
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15. External Validation of a Multivariate Model for Targeted Surfactant Replacement

Author

Raimondi, Francesco, primary, Dolce, Pasquale, additional, Veropalumbo, Claudio, additional, Sierchio, Enrico, additional, Gregorio Hernandez, Rebeca, additional, Rodriguez Fanjul, Javier, additional, Meneghin, Fabio, additional, Raschetti, Roberto, additional, Bonadies, Luca, additional, Corsini, Iuri, additional, Alonso Ojembarrena, Almudena, additional, Salomè, Serena, additional, Rodeño Fernandez, Lorena, additional, Sanchez Luna, Manuel, additional, Lista, Gianluca, additional, Mosca, Fabio, additional, Dani, Carlo, additional, Baraldi, Eugenio, additional, Giordano, Lucio, additional, Davis, Peter G, additional, and Capasso, Letizia, additional

Published
2023
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19. External Validation of a Multivariate Model for Targeted Surfactant Replacement.

Author

Raimondi, Francesco, Dolce, Pasquale, Veropalumbo, Claudio, Sierchio, Enrico, Gregorio Hernandez, Rebeca, Rodriguez Fanjul, Javier, Meneghin, Fabio, Raschetti, Roberto, Bonadies, Luca, Corsini, Iuri, Alonso Ojembarrena, Almudena, Salomè, Serena, Rodeño Fernandez, Lorena, Sanchez Luna, Manuel, Lista, Gianluca, Mosca, Fabio, Dani, Carlo, Baraldi, Eugenio, Giordano, Lucio, and Davis, Peter G

Subjects
SURFACE active agents, RESPIRATORY distress syndrome, PREMATURE infants, MODEL validation, OXYGEN saturation
Abstract

Introduction: Early targeted surfactant therapy for preterm infants is recommended but the best criteria to personalize treatment are unclear. We validate a previously published multivariate prognostic model based on gestational age (GA), lung ultrasound score (LUS), and oxygen saturation to inspire oxygen fraction ratio (SatO2/FiO2) using an independent data set. Methods: Pragmatic, observational study in 10 Italian and Spanish NICUs, including preterm babies (250 and 336 weeks divided into 3 GA intervals) with clinical signs of respiratory distress syndrome and stabilized on CPAP. LUS and SatO2/FiO2 were collected soon after stabilization. Their prognostic accuracy was evaluated on the subsequent surfactant administration by a rigorously masked physician. Results: One hundred seventy-five infants were included in the study. Surfactant was given to 74% infants born at 25–27 weeks, 38.5% at 28–30 weeks, and 26.5% at 31–33 weeks. The calibration curve comparing the validation and the development populations showed significant overlap with an intercept = 0.08, 95% CI (−0.34; 0.5) and a slope = 1.53, 95% CI (1.07–1.98). The validation cohort had a high predictive accuracy. Its ROC curve showed an AUC = 0.95, 95% CI (0.91–0.99) with sensitivity = 0.93, 95% CI (0.83–0.98), specificity = 0.81, 95% CI (0.73–0.88), PPV = 0.76, 95% CI (0.65–0.84), NPV = 0.95, 95% CI (0.88–0.98). LUS ≥9 demonstrated the highest sensitivity (0.91, 95% CI [0.82–0.97]) and specificity = 0.81, 95% CI (0.72–0.88) as individual predictor. LUS and SatO2/FiO2 prognostic performances varied with GA. Conclusion: We validated a prognostic model based on LUS and Sat/FiO2 to facilitate early, customized surfactant administration that may improve respiratory management of preterm neonates. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Fluid restriction in management of patent ductus arteriosus in Italy: a nationwide survey

Author

Francescato, Gaia, primary, Capolupo, Irma, additional, Cerbo, Rosa Maria, additional, Doni, Daniela, additional, Ficial, Benjamim, additional, Fiocchi, Stefano, additional, Matina, Federico, additional, Milani, Gregorio Paolo, additional, Mizzoni, Fabio, additional, Salvadori, Sabrina, additional, Savoia, Marilena, additional, and Corsini, Iuri, additional

Published
2022
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26. A scoping review of echocardiographic and lung ultrasound biomarkers of bronchopulmonary dysplasia in preterm infants

Author

Martini, Silvia, Corsini, Iuri, Corvaglia, Luigi, Suryawanshi, Pradeep, Chan, Belinda, Singh, Yogen, and Apollo - University of Cambridge Repository

Subjects
Pediatrics, Perinatology and Child Health, bronchopulmonary dysplasia, pulmonary hypertension, echocardiography, preterm infants, lung ultrasound
Abstract

Peer reviewed: True, Despite recent improvements in neonatal care, moderate to severe bronchopulmonary dysplasia (BPD) is still associated with high mortality and with an increased risk of developing pulmonary hypertension (PH). This scoping review provides an updated overview of echocardiographic and lung ultrasound biomarkers associated with BPD and PH, and the parameters that may prognosticate their development and severity, which could be clinically helpful to undertake preventive strategies. A literature search for published clinical studies was conducted in PubMed using MeSH terms, free-text words, and their combinations obtained through appropriate Boolean operators. It was found that the echocardiography biomarkers for BPD, and especially those assessing right ventricular function, are reflective of the high pulmonary vascular resistance and PH, indicating a strong interplay between heart and lung pathophysiology; however, early assessment (e.g., during the first 1-2 weeks of life) may not successfully predict later BPD development. Lung ultrasound indicating poor lung aeration at day 7 after birth has been reported to be highly predictive of later development of BPD at 36 weeks' postmenstrual age. Evidence of PH in BPD infants increases risk of mortality and long-term PH; hence, routine PH surveillance in all at risk preterm infants at 36 weeks, including an echocardiographic assessment, may provide useful information. Progress has been made in identifying the echocardiographic parameters on day 7 and 14 to predict later development of pulmonary hypertension. More studies on sonographic markers, and especially on echocardiographic parameters, are needed for the validation of the currently proposed parameters and the timing of assessment before recommendations can be made for the routine clinical practice.

Published
2023

43. Lung ultrasound score progress in neonatal respiratory distress syndrome

Author

Raimondi, Francesco, Migliaro, Fiorella, Corsini, Iuri, Meneghin, Fabio, Dolce, Pasquale, Pierri, Luca, Perri, Alessandro, Aversa, Salvatore, Nobile, Stefano, Lama, Silvia, Varano, Silvia, Savoia, Marilena, Gatto, Sara, Leonardi, Valentina, Capasso, Letizia, Paolo Carnielli, Virgilio, Mosca, Fabio, Dani, Carlo, Vento, Giovanni, Lista, Gianluca, Alessandro Perri, Stefano Nobile (ORCID:0000-0002-5304-1485), Giovanni Vento (ORCID:0000-0002-8132-5127), Raimondi, Francesco, Migliaro, Fiorella, Corsini, Iuri, Meneghin, Fabio, Dolce, Pasquale, Pierri, Luca, Perri, Alessandro, Aversa, Salvatore, Nobile, Stefano, Lama, Silvia, Varano, Silvia, Savoia, Marilena, Gatto, Sara, Leonardi, Valentina, Capasso, Letizia, Paolo Carnielli, Virgilio, Mosca, Fabio, Dani, Carlo, Vento, Giovanni, Lista, Gianluca, Alessandro Perri, Stefano Nobile (ORCID:0000-0002-5304-1485), and Giovanni Vento (ORCID:0000-0002-8132-5127)

Abstract

BACKGROUND AND OBJECTIVES: The utility of a lung ultrasound score (LUS) has been described in the early phases of neonatal respiratory distress syndrome (RDS). We investigated lung ultrasound as a tool to monitor respiratory status in preterm neonates throughout the course of RDS. METHODS: Preterm neonates, stratified in 3 gestational age cohorts (25-27, 28-30, and 31-33 weeks), underwent lung ultrasound at weekly intervals from birth. Clinical data, respiratory support variables, and major complications (sepsis, patent ductus arteriosus, pneumothorax, and persistent pulmonary hypertension of the neonate) were also recorded. RESULTS: We enrolled 240 infants in total. The 3 gestational age intervals had significantly different LUS patterns. There was a significant correlation between LUS and the ratio of oxygen saturation to inspired oxygen throughout the admission, increasing with gestational age (b = 20.002 [P,.001] at 25-27 weeks; b = 20.006 [P,.001] at 28-30 weeks; b = 20.012 [P,.001] at 31-33 weeks). Infants with complications had a higher LUS already at birth (12 interquartile range 13-8 vs 8 interquartile range 12-4 control group; P =.001). In infants 25 to 30 weeks' gestation, the LUS at 7 days of life predicted bronchopulmonary dysplasia with an area under the curve of 0.82 (95% confidence interval 0.71 to 93). CONCLUSIONS: In preterm neonates affected by RDS, the LUS trajectory is gestational age dependent, significantly correlates with the oxygenation status, and predicts bronchopulmonary dysplasia. In this population, LUS is a useful, bedside, noninvasive tool to monitor the respiratory status.

Published
2021

46. Impact of Aortic Diameter Measurements at Three Anatomical Landmarks on Left Ventricular Output Calculation in Neonates.

Author

Ficial, Benjamim, Bonafiglia, Elena, Gangemi, Antonella, Clemente, Maria, Cappelleri, Alessia, Corsini, Iuri, and Biban, Paolo

Subjects
PREMATURE infants, NEWBORN infants, SINUS of valsalva, AORTA, MAGNETIC resonance imaging, AORTIC valve
Abstract

Objectives: To assess reproducibility and accuracy of left ventricular output (LVO) quantifications in neonates, when left ventricular outflow tract diameter (LVOTD) was measured at the hinges of the aortic valve (AV), at the aortic sinus (AS), and at the sinotubular junction (STJ). Methods: This was an observational study. In the first cohort of very preterm neonates, we assessed intraobserver and interobserver repeatability of LVOTD measured at the AV, AS, and STJ and of the corresponding LVO. In the second cohort of older neonates, we compared paired LVO measurements by echo and magnetic resonance imaging (MRI). Results: In the first cohort of 48 neonates, mean (standard deviation) weight and age at scan were 1046 (302) g and 28.1 (2.7) weeks. Interobserver bias (95% limits of agreement [LOA]) for LVOTD at the AV, AS, and STJ was 0 (−0.3 to 0.3) mm, 0 (−0.7 to 0.7) mm, and 0 (−0.8 to 0.7) mm, respectively. Interobserver bias (95% LOA) for the corresponding LVO was −1.3 (−31 to 33) ml/kg/min, −0.5 (−88 to 87) ml/kg/min, and −7.2 (−83 to 69) ml/kg/min, respectively. In the second cohort of 10 neonates, median (range) weight and age at scan were 1942 (970–3640) g and 37.2 (31.7–39.8) weeks. LVO measured at the AV showed stronger agreement with MRI: bias (LOA) −10.6 (−74 to 52) ml/kg/min, compared to LVO measured at AS and STJ: 194 (−0.5 to 388) ml/kg/min and 43 (−72 to 159) ml/kg/min respectively. Conclusions: Reproducibility and accuracy of LVO quantification by echo were better when aortic diameter was measured at AV. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Lung Ultrasound Score Progress in Neonatal Respiratory Distress Syndrome

Author

Raimondi, Francesco, primary, Migliaro, Fiorella, additional, Corsini, Iuri, additional, Meneghin, Fabio, additional, Dolce, Pasquale, additional, Pierri, Luca, additional, Perri, Alessandro, additional, Aversa, Salvatore, additional, Nobile, Stefano, additional, Lama, Silvia, additional, Varano, Silvia, additional, Savoia, Marilena, additional, Gatto, Sara, additional, Leonardi, Valentina, additional, Capasso, Letizia, additional, Carnielli, Virgilio Paolo, additional, Mosca, Fabio, additional, Dani, Carlo, additional, Vento, Giovanni, additional, and Lista, Gianluca, additional

Published
2021
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49. Isoprostanes as Biomarker for Patent Ductus Arteriosus in Preterm Infants

Author

Child Health, MS Neonatologie, Brain, Coviello, Caterina, Tataranno, Maria Luisa, Corsini, Iuri, Leonardi, Valentina, Longini, Mariangela, Bazzini, Francesco, Buonocore, Giuseppe, Dani, Carlo, Child Health, MS Neonatologie, Brain, Coviello, Caterina, Tataranno, Maria Luisa, Corsini, Iuri, Leonardi, Valentina, Longini, Mariangela, Bazzini, Francesco, Buonocore, Giuseppe, and Dani, Carlo

Published
2020

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