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1. Papaver somniferum in seventeenth century (Italy): archaeotoxicological study on brain and bone samples in patients from a hospital in Milan

Author

Giordano, Gaia, Mattia, Mirko, Biehler-Gomez, Lucie, Boracchi, Michele, Tritella, Stefania, Maderna, Emanuela, Porro, Alessandro, Corsi Romanelli, Massimiliano Marco, Franchini, Antonia Francesca, Galimberti, Paolo Maria, Slavazzi, Fabrizio, Sardanelli, Francesco, Di Candia, Domenico, and Cattaneo, Cristina

Published
2023
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2. Effects of COVID-19 on bone fragility: a new perspective from osteoimmunological biomarkers.

Author

Galliera, Emanuela, Massaccesi, Luca, Mangiavini, Laura, De Vecchi, Elena, Villa, Francesca, Corsi Romanelli, Massimiliano Marco, and Peretti, Giuseppe

Subjects
COVID-19 pandemic, BONE remodeling, BONE resorption, OLDER patients, PROGNOSIS, ORTHOPEDIC surgery
Abstract

Introduction: While there is an increasing understanding of COVID-19's effect on different organs, little is known about the effect of the disease on bone turnover and remodeling so far. Osteoimmunological biomarkers have been described as potential indicators of bone remodeling in inflammatory conditions, but their potential role in evaluating the effect of COVID-19 on bone fragility has not been explored so far. Methods: The present study aims to measure the osteoimmunological biomarkers in elderly patients undergoing orthopedic surgery, to evaluate the potential effect of COVID-19 on the bone response to the surgery. Results: In our patients, the RANKL/OPG ratio indicated an increase of bone resorption in COVID-19-positive patients, confirming a strong diagnostic and prognostic value. RANKL/OPG displays a good correlation with the bone fragility maker FGF23, indicating that this parameter is a reliable maker of bone fragility in COVID-19 patients and could provide useful and comprehensive information about inflammation-induced bone loss. Consistently, the RANKL/OPG ratio showed a good correlation also with the two inflammatory markers IL-6 and sRAGE. Discussion: Taken together these results indicate that the use of an osteoimmunological biomarker like the RANKL/OPG ratio could provide a significant improvement in the clinical evaluation of the COVID-19 effect on bone loss. This aspect is extremely important in elderly patients undergoing orthopedic surgery, which can manifest more severe effects of COVID-19 and present an increased level of age-induced bone fragility. [ABSTRACT FROM AUTHOR]

Published
2024
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6. BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection

Author

Malavazos, Alexis Elias, primary, Dubini, Carola, additional, Milani, Valentina, additional, Boveri, Sara, additional, Meregalli, Chiara, additional, Bertolini, Caterina, additional, Buscemi, Carola, additional, Cardani, Rosanna, additional, Renna, Laura Valentina, additional, Trevisan, Manuel Bruno, additional, Scravaglieri, Valentina, additional, Cuppone, Maria Teresa, additional, Menicanti, Lorenzo, additional, Costa, Elena, additional, Ambrogi, Federico, additional, Ruocco, Chiara, additional, Carruba, Michele, additional, Iacobellis, Gianluca, additional, Nisoli, Enzo, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2023
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8. Proinsulin C-peptide modulates the expression of ERK1/2, type I collagen and RANKL in human osteoblast-like cells (Saos-2)

Author

Russo, Cristina, Lazzaro, Veronica, Gazzaruso, Carmine, Maurotti, Samantha, Ferro, Yvelise, Pingitore, Piero, Fumo, Francesca, Coppola, Adriana, Gallotti, Pietro, Zambianchi, Valentina, Fodaro, Mariangela, Galliera, Emanuela, Marazzi, Monica Gioia, Corsi Romanelli, Massimiliano Marco, Giannini, Sandro, Romeo, Stefano, Pujia, Arturo, and Montalcini, Tiziana

Published
2017
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9. Rationale and design of the CV-PREVITAL study: an Italian multiple cohort randomised controlled trial investigating innovative digital strategies in primary cardiovascular prevention

Author

Baldassarre, Damiano, primary, Iacoviello, Licia, additional, Baetta, Roberta, additional, Roncaglioni, Maria Carla, additional, Condorelli, Gianluigi, additional, Remuzzi, Giuseppe, additional, Gensini, Gianfranco, additional, Frati, Luigi, additional, Ricciardi, Walter, additional, Conaldi, Pier Giulio, additional, Uccelli, Antonio, additional, Blandini, Fabio, additional, Bosari, Silvano, additional, Scambia, Giovanni, additional, Fini, Massimo, additional, Di Malta, Antonio, additional, Amato, Mauro, additional, Veglia, Fabrizio, additional, Bonomi, Alice, additional, Klersy, Catherine, additional, Colazzo, Francesca, additional, Pengo, Martino, additional, Gorini, Francesca, additional, Auteri, Luciana, additional, Ferrante, Giuseppe, additional, Baviera, Marta, additional, Ambrosio, Giuseppe, additional, Catapano, Alberico, additional, Gialluisi, Alessandro, additional, Malavazos, Alexis Elias, additional, Castelvecchio, Serenella, additional, Corsi-Romanelli, Massimiliano Marco, additional, Cardani, Rosanna, additional, Rovere, Maria Teresa La, additional, Agnese, Valentina, additional, Pane, Bianca, additional, Prati, Daniele, additional, Spinardi, Laura, additional, Liuzzo, Giovanna, additional, Arbustini, Eloisa, additional, Volterrani, Maurizio, additional, Visconti, Marco, additional, Werba, José Pablo, additional, Genovese, Stefano, additional, Bilo, Grzegorz, additional, Invitti, Cecilia, additional, Di Blasio, Anna, additional, Lombardi, Carolina, additional, Faini, Andrea, additional, Rosa, Debora, additional, Ojeda-Fernández, Luisa, additional, Foresta, Andreana, additional, De Curtis, Amalia, additional, Di Castelnuovo, Augusto, additional, Scalvini, Simonetta, additional, Pierobon, Antonia, additional, Gorini, Alessandra, additional, Valenti, Luca, additional, Luzi, Livio, additional, Racca, Annarosa, additional, Bandi, Manuela, additional, Tremoli, Elena, additional, Menicanti, Lorenzo, additional, Parati, Gianfranco, additional, and Pompilio, Giulio, additional

Published
2023
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13. BNT162b2 Booster Dose Elicits a Robust Antibody Response in Subjects with Abdominal Obesity and Previous SARS-CoV-2 Infection.

Author

Malavazos, Alexis Elias, Dubini, Carola, Milani, Valentina, Boveri, Sara, Meregalli, Chiara, Bertolini, Caterina, Buscemi, Carola, Cardani, Rosanna, Renna, Laura Valentina, Trevisan, Manuel Bruno, Scravaglieri, Valentina, Cuppone, Maria Teresa, Menicanti, Lorenzo, Costa, Elena, Ambrogi, Federico, Ruocco, Chiara, Carruba, Michele, Iacobellis, Gianluca, Nisoli, Enzo, and Corsi Romanelli, Massimiliano Marco

Subjects
BOOSTER vaccines, ANTIBODY formation, COVID-19 vaccines, ABDOMINAL adipose tissue, SARS-CoV-2
Abstract

Little is known about the long-term durability of the induced immune response in subjects with obesity, particularly in those with an abdominal distribution of adipose tissue. We evaluated SARS-CoV-2-specific antibody responses after BNT162b2 vaccine booster dose, comparing individuals with and without abdominal obesity (AO), discerning between individuals previously infected or not. IgG-TrimericS were measured in 511 subjects at baseline, on the 21st day after vaccine dose 1, and at 1, 3, 6, and 9 months from dose 2, and at 1 and 3 months following the booster dose. To detect SARS-CoV-2 infection, nucleocapsid antibodies were measured at baseline and at the end of the study. Multivariable linear regression evaluated the three-month difference in the absolute variation in IgG-TrimericS levels from booster dose, showing AO and SARS-CoV-2 infection status interactions (p = 0.016). Regardless of possible confounding factors and IgG-TrimericS levels at the booster dose, AO is associated with a higher absolute change in IgG-TrimericS in prior infected individuals (p = 0.0125). In the same regression model, no interaction is highlighted using BMI (p = 0.418). The robust response in the development of antibodies after booster dose, observed in people with AO and previous infection, may support the recommendations to administer a booster dose in this population group. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Human Epicardial Adipose Tissue Expresses Glucose-dependent Insulinotropic Polypeptide, Glucagon and Glucagon-Like Peptide 1 Receptors as Potential Targets of Pleiotropic Therapies

Author

Malavazos, Alexis Elias, primary, Iacobellis, Gianluca, additional, Dozio, Elena, additional, Basilico, Sara, additional, Di Vincenzo, Angelica, additional, Dubini, Carola, additional, Menicanti, Lorenzo, additional, Vianello, Elena, additional, Meregalli, Chiara, additional, Ruocco, Chiara, additional, Ragni, Maurizio, additional, Secchi, Francesco, additional, Spagnolo, Pietro, additional, Castelvecchio, Serenella, additional, Morricone, Lelio, additional, Buscemi, Silvio, additional, Giordano, Antonio, additional, Goldberger, Jeffrey J, additional, Carruba, Michele, additional, Cinti, Saverio, additional, Corsi Romanelli, Massimiliano Marco, additional, and Nisoli, Enzo, additional

Published
2023
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19. Antibody responses to BNT162b2 mRNA vaccine: Infection‐naïve individuals with abdominal obesity warrant attention

Author

Malavazos, Alexis Elias, primary, Basilico, Sara, additional, Iacobellis, Gianluca, additional, Milani, Valentina, additional, Cardani, Rosanna, additional, Boniardi, Federico, additional, Dubini, Carola, additional, Prandoni, Ilaria, additional, Capitanio, Gloria, additional, Renna, Laura Valentina, additional, Boveri, Sara, additional, Rigolini, Roberta, additional, Carrara, Matteo, additional, Spuria, Giovanni, additional, Cuppone, Teresa, additional, D’acquisto, Aurelia, additional, Carpinelli, Luca, additional, Sacchi, Marta, additional, Morricone, Lelio, additional, Secchi, Francesco, additional, Costa, Elena, additional, Menicanti, Lorenzo, additional, Nisoli, Enzo, additional, Carruba, Michele, additional, Ambrogi, Federico, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2022
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21. Antibody responses to BNT162b2 mRNA vaccine: infection-naïve individuals with abdominal obesity warrant attention

Author

Malavazos, Alexis Elias, primary, Basilico, Sara, additional, Iacobellis, Gianluca, additional, Milani, Valentina, additional, Cardani, Rosanna, additional, Boniardi, Federico, additional, Dubini, Carola, additional, Prandoni, Ilaria, additional, Capitanio, Gloria, additional, Renna, Laura Valentina, additional, Boveri, Sara, additional, Carrara, Matteo, additional, Spuria, Giovanni, additional, Cuppone, Teresa, additional, D’acquisto, Aurelia, additional, Carpinelli, Luca, additional, Sacchi, Marta, additional, Morricone, Lelio, additional, Secchi, Francesco, additional, Costa, Elena, additional, Menicanti, Lorenzo, additional, Nisoli, Enzo, additional, Carruba, Michele, additional, Ambrogi, Federico, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2021
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22. Epicardial fat inflammation response to COVID‐19 therapies

Author

Iacobellis, Gianluca, primary, Malavazos, Alexis Elias, additional, Basilico, Sara, additional, Tresoldi, Silvia, additional, Rinaldo, Rocco Francesco, additional, Dubini, Carola, additional, Capitanio, Gloria, additional, Serpi, Francesca, additional, Schiaffino, Simone, additional, Oliva, Omar Alessandro, additional, Cariati, Maurizio, additional, Morricone, Lelio, additional, Centanni, Stefano, additional, Sardanelli, Francesco, additional, Carruba, Michele, additional, Corsi Romanelli, Massimiliano Marco, additional, and Secchi, Francesco, additional

Published
2021
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23. Osteopontin: The Molecular Bridge between Fat and Cardiac–Renal Disorders

Author

Vianello, Elena, Kalousová, Marta, Dozio, Elena, Tacchini, Lorenza, Zima, Tomáš, and Corsi Romanelli, Massimiliano Marco

Subjects
Inflammation, visceral adipose tissue (VAT), obesity, Heart Diseases, Myocardium, cardiovascular diseases (CVDs), Review, chronic kidney disease (CKD), Intra-Abdominal Fat, Kidney, stomatognathic system, Adipose Tissue, osteopontin (OPN), Humans, Kidney Diseases, Osteopontin, Insulin Resistance, renal disorders
Abstract

Osteopontin (OPN) is a multifaceted matricellular protein, with well-recognized roles in both the physiological and pathological processes in the body. OPN is expressed in the main organs and cell types, in which it induces different biological actions. During physiological conditioning, OPN acts as both an intracellular protein and soluble excreted cytokine, regulating tissue remodeling and immune-infiltrate in adipose tissue the heart and the kidney. In contrast, the increased expression of OPN has been correlated with the severity of the cardiovascular and renal outcomes associated with obesity. Indeed, OPN expression is at the “cross roads” of visceral fat extension, cardiovascular diseases (CVDs) and renal disorders, in which OPN orchestrates the molecular interactions, leading to chronic low-grade inflammation. The common factor associated with OPN overexpression in adipose, cardiac and renal tissues seems attributable to the concomitant increase in visceral fat size and the increase in infiltrated OPN+ macrophages. This review underlines the current knowledge on the molecular interactions between obesity and the cardiac–renal disorders ruled by OPN.

Published
2020

24. Osteomyelitis, Oxidative Stress and Related Biomarkers.

Author

Massaccesi, Luca, Galliera, Emanuela, Pellegrini, Antonio, Banfi, Giuseppe, and Corsi Romanelli, Massimiliano Marco

Subjects
OXIDATIVE stress, OSTEOCLASTS, OSTEOMYELITIS, BONE remodeling, BIOMARKERS, BONE resorption, DISEASE management
Abstract

Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being Staphylococcus aureus, affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis. Here we describe this, analyzing the effects of OS in bone remodeling and discussing the need for new, easy-to-measure and widely available OS biomarkers that will provide valid support in the management of the disease. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Epicardial Fat Inflammation in Severe COVID‐19

Author

Iacobellis, Gianluca, primary, Secchi, Francesco, additional, Capitanio, Gloria, additional, Basilico, Sara, additional, Schiaffino, Simone, additional, Boveri, Sara, additional, Sardanelli, Francesco, additional, Corsi Romanelli, Massimiliano Marco, additional, and Malavazos, Alexis Elias, additional

Published
2020
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28. Correlative Study on Impaired Prostaglandin E2 Regulation in Epicardial Adipose Tissue and Its Role in Maladaptive Cardiac Remodeling via EPAC2 and ST2 Signaling in Overweight Cardiovascular Disease Subjects

Author

Vianello, Elena, Dozio, Elena, Bandera, Francesco, Froldi, Marco, Micaglio, Emanuele, Lamont, John, Tacchini, Lorenza, Schmitz, Gerd, and Corsi Romanelli, Massimiliano Marco

Subjects
interleukin(il)-33, ep3 receptor, prostaglandin e2 (pge2), Article, Dinoprostone, lcsh:Chemistry, Guanine Nucleotide Exchange Factors, Humans, epicardial adipose tissue (eat), stimulating growth factor 2 (st2), Body Weights and Measures, lcsh:QH301-705.5, prostaglandin E2 (PGE2), Adiposity, Aged, Prostaglandin-E Synthases, Aged, 80 and over, ep4 receptor, Ventricular Remodeling, fat mass, Middle Aged, Overweight, Interleukin-1 Receptor-Like 1 Protein, lcsh:Biology (General), lcsh:QD1-999, Cardiovascular Diseases, Echocardiography, cardiovascular diseases (cvds), Heart Function Tests, Receptors, Prostaglandin E, EP3 Subtype, exchange protein directly activated by camp isoform 2 (epac2), Pericardium, Biomarkers, Signal Transduction
Abstract

There is recent evidence that the dysfunctional responses of a peculiar visceral fat deposit known as epicardial adipose tissue (EAT) can directly promote cardiac enlargement in the case of obesity. Here, we observed a newer molecular pattern associated with LV dysfunction mediated by prostaglandin E2 (PGE2) deregulation in EAT in a cardiovascular disease (CVD) population. A series of 33 overweight CVD males were enrolled and their EAT thickness, LV mass, and volumes were measured by echocardiography. Blood, plasma, EAT, and SAT biopsies were collected for molecular and proteomic assays. Our data show that PGE2 biosynthetic enzyme (PTGES-2) correlates with echocardiographic parameters of LV enlargement: LV diameters, LV end diastolic volume, and LV masses. Moreover, PTGES-2 is directly associated with EPAC2 gene (r = 0.70, p < 0.0001), known as a molecular inducer of ST2/IL-33 mediators involved in maladaptive heart remodelling. Furthermore, PGE2 receptor 3 (PTEGER3) results are downregulated and its expression is inversely associated with ST2/IL-33 expression. Contrarily, PGE2 receptor 4 (PTGER4) is upregulated in EAT and directly correlates with ST2 molecular expression. Our data suggest that excessive body fatness can shift the EAT transcriptome to a pro-tissue remodelling profile, may be driven by PGE2 deregulation, with consequent promotion of EPAC2 and ST2 signalling.

Published
2020

30. Corrigendum to “Correlational study on altered epicardial adipose tissue as a stratification risk factor for valve disease progression through IL-13 signaling” [Journal of Molecular and Cellular Cardiology 132 (2019) 210–2018]

Author

Vianello, Elena, primary, Marrocco-Trischitta, Massimiliano Maria, additional, Dozio, Elena, additional, Bandera, Francesco, additional, Tacchini, Lorenza, additional, Canciani, Elena, additional, Dellavia, Claudia, additional, Schmitz, Gerd, additional, Menicanti, Lorenzo, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2019
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32. Irisin: A Potential Link between Physical Exercise and Metabolism-An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People

Author

Benedini, Stefano, Dozio, Elena, Invernizzi, Pietro Luigi, Vianello, Elena, Banfi, Giuseppe, Terruzzi, Ileana, Luzi, Livio, Corsi Romanelli, Massimiliano Marco, Benedini, Stefano, Dozio, Elena, Invernizzi, Pietro Luigi, Vianello, Elena, Banfi, Giuseppe, Terruzzi, Ileana, Luzi, Livio, and Corsi Romanelli, Massimiliano Marco

Subjects
Adult, Blood Glucose, Male, lcsh:RC648-665, Article Subject, Adolescent, Anticoagulants, Lipid Metabolism, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Healthy Volunteers, Fibronectins, Young Adult, Cholesterol, Glucose, Athletes, Case-Control Studies, Humans, Insulin, Female, Insulin Resistance, Sedentary Behavior, Exercise, Research Article
Abstract

We compared irisin levels among groups of differently trained healthy individuals to explore the role of irisin as a physiological linker between exercise and metabolic health. Irisin and biochemical parameters of glucose and lipid metabolism were assessed in 70 healthy volunteers stratified for sport performance level into four groups: (1) 20 elite athletes of national level, (2) 20 subelite athletes of local level, (3) 20 recreational athletes, and (4) 10 sedentary subjects. All biochemical parameters were within the ranges of normality. Fasting glucose, HOMA-IR, and total cholesterol levels were inversely related to the degree of physical activity. HbA1c was higher in elite athletes compared to all the other groups (p < 0.01). A U-shaped relation between free fatty acids and the degree of physical activity was observed. All groups showed similar plasma irisin levels. After correction for the degree of insulin resistance (irisin/HOMA-IR), elite athletes showed higher levels compared to sedentary and recreational subjects (p < 0.01 and p < 0.05, resp.). In addition, the number of metabolic parameters correlated with irisin increased at increasing the training status. Our study suggests a correlation between sport performance, insulin sensitivity, and irisin levels. Irisin may be one potential mediator of the beneficial effects of exercise on metabolic profile.

Published
2017

34. Levels of uric acid in erectile dysfunction of different aetiology

Author

Barassi, Alessandra, primary, Corsi Romanelli, Massimiliano Marco, additional, Pezzilli, Raffaele, additional, Dozio, Elena, additional, Damele, Clara Anna Linda, additional, Vaccalluzzo, Liborio, additional, Di Dario, Marco, additional, Goi, Giancarlo, additional, Papini, Nadia, additional, Massaccesi, Luca, additional, Colpi, Giovanni Maria, additional, and Melzi d’Eril, Gian Vico, additional

Published
2018
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35. Presepsin: A potential biomarker of PJI? A comparative analysis with known and new infection biomarkers

Author

Marazzi, Monica Gioia, primary, Randelli, Filippo, additional, Brioschi, Marco, additional, Drago, Lorenzo, additional, Romanò, Carlo Luca, additional, Banfi, Giuseppe, additional, Massaccesi, Luca, additional, Crapanzano, Calogero, additional, Morelli, Franca, additional, Corsi Romanelli, Massimiliano Marco, additional, and Galliera, Emanuela, additional

Published
2017
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42. Procoagulatory State in Inflammatory Bowel Diseases Is Promoted by Impaired Intestinal Barrier Function

Author

Pastorelli, Luca, primary, Dozio, Elena, additional, Pisani, Laura Francesca, additional, Boscolo-Anzoletti, Massimo, additional, Vianello, Elena, additional, Munizio, Nadia, additional, Spina, Luisa, additional, Tontini, Gian Eugenio, additional, Peyvandi, Flora, additional, Corsi Romanelli, Massimiliano Marco, additional, and Vecchi, Maurizio, additional

Published
2015
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43. Evaluation of High Sensitive Troponin in Erectile Dysfunction

Author

Barassi, Alessandra, primary, Pezzilli, Raffaele, additional, Morselli-Labate, Antonio Maria, additional, Dozio, Elena, additional, Massaccesi, Luca, additional, Ghilardi, Francesca, additional, Damele, Clara Anna Linda, additional, Colpi, Giovanni Maria, additional, Melzi d’Eril, Gian Vico, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2015
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44. Creatine kinase elevation: a neglected clue to the diagnosis of polymyositis. A case report.

Author

Sitzia, Clementina, Sansone, Valeria Ada, and Corsi Romanelli, Massimiliano Marco

Subjects
POLYMYOSITIS, CREATINE kinase, AMINOTRANSFERASES, DEGLUTITION disorders, THERAPEUTIC use of immunoglobulins, BLOOD serum analysis
Abstract

The article presents a case study of a 47-year-old man who complained of fatigue and dysphagia. Topics include his medical history that revealed a progressive inability to swallow solid foods and liquids and unexplained weight loss; tests confirming elevation of transaminase levels and serum creatine kinase levels; clinical diagnosis of polymyositis by his muscle biopsy; and his treatment with steroid therapy and intravenous immunoglobulin.

Published
2019
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46. Increased reactive oxygen species production in epicardial adipose tissues from coronary artery disease patients is associated with brown-to-white adipocyte trans-differentiation

Author

Dozio, Elena, primary, Vianello, Elena, additional, Briganti, Silvia, additional, Fink, Bruno, additional, Malavazos, Alexis Elias, additional, Scognamiglio, Elisabetta Thea, additional, Dogliotti, Giada, additional, Sigrüener, Alexander, additional, Schmitz, Gerd, additional, and Corsi Romanelli, Massimiliano Marco, additional

Published
2014
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47. Expression of the Receptor for Advanced Glycation End Products in Epicardial Fat: Link with Tissue Thickness and Local Insulin Resistance in Coronary Artery Disease.

Author

Dozio, Elena, Vianello, Elena, Briganti, Silvia, Lamont, John, Tacchini, Lorenza, Schmitz, Gerd, and Corsi Romanelli, Massimiliano Marco

Subjects
GLYCOSYLATED hemoglobin, TISSUES, INSULIN resistance, CORONARY disease, DNA microarrays
Abstract

Increased expression of receptor for advanced glycation end products (RAGE) in adipose tissue has been associated with inflammation, adipocyte hypertrophy, and impaired insulin signal. Epicardial adipose tissue (EAT), a visceral fat surrounding the myocardium, is potentially involved in the onset/progression of coronary artery disease (CAD). To date, the role of RAGE in EAT has not been explored much. We examined whether the RAGE expression in EAT was associated with EAT adiposity and metabolic dysfunctions normally found in CAD patients. EAT samples were obtained from 33 patients undergoing open-heart surgery. EAT expression of RAGE, GLUT4, adiponenctin, GLO1, HMGB1, TLR-4, and MyD88 was analyzed by microarray. EAT thickness was quantified by echocardiography. Anthropometric measures and clinical parameters were taken. BMI, HOMA-IR, and LAP indices were calculated. With increasing RAGE expression in EAT we observed increases in EAT thickness, reduced expression of GLUT4, adiponectin, and GLO1, and elevations of HMGB1, TLR-4, and MyD88. There were significant correlations between RAGE and EAT thickness and between RAGE and the genes. LAP was higher in patients with increased RAGE expression. Our data suggest that in CAD patients RAGE may be involved in promoting EAT adiposity and metabolic dysfunction, such as impaired insulin signaling. [ABSTRACT FROM AUTHOR]

Published
2015
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48. Low heart-type fatty acid binding protein level during aging may protect down syndrome people against atherosclerosis.

Author

Vianello, Elena, Dogliotti, Giada, Dozio, Elena, and Corsi Romanelli, Massimiliano Marco

Subjects
AGING, ATHEROSCLEROSIS, DOWN syndrome, FATTY acid-binding proteins, CORONARY disease, FATTY acids, CYTOKINES, INTELLECTUAL disabilities
Abstract

Background: Aging is considered an important independent risk factor for atherosclerosis. Down syndrome people (DS) display an accelerated aging process compared to healthy subjects, anyway they are relatively resistant to developing atherosclerosis. The mechanisms involved in such protective effect are not well known. Since heart-type fatty acid binding protein (H-FABP) is a protein involved in the transport of fatty acids and it has been recently correlated with the presence of atherosclerosis, we aimed to measure H-FABP level both in DS and in healthy subjects during aging to evaluate the association between this molecule, aging and atherosclerosis. Findings: We quantified plasmatic H-FABP level in three groups of male DS and age-matched healthy subjects (children, age 2-14 years; adults, age 20-50 years; elderly, > 60 years) using a biochip array analyzer. We observed that aging is associated with increased H-FABP level in healthy subjects but not in DS which display both the same protein level in the different ages of life and have also lower level compared to their age-matched healthy subjects. Conclusion: Reduced H-FABP level during aging in DS may play a protective role against atherosclerosis. The potential involvement of H-FABP in the relationship between aging, atherosclerosis and development of coronary artery disease needs further investigations. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Osteomyelitis, Oxidative Stress and Related Biomarkers

Author

Luca Massaccesi, Emanuela Galliera, Antonio Pellegrini, Giuseppe Banfi, Massimiliano Corsi Romanelli, Massaccesi, Luca, Galliera, Emanuela, Pellegrini, Antonio, Banfi, Giuseppe, and Corsi Romanelli, Massimiliano Marco

Subjects
osteomyelitis (OM), reactive oxygen species (ROS), oxidative stress (OS), oxidative stress biomarkers, Physiology, Clinical Biochemistry, Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio, Settore MED/05 - Patologia Clinica, Cell Biology, Molecular Biology, Biochemistry, Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica
Abstract

Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being Staphylococcus aureus, affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis. Here we describe this, analyzing the effects of OS in bone remodeling and discussing the need for new, easy-to-measure and widely available OS biomarkers that will provide valid support in the management of the disease.

Published
2022

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