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2. Hashimoto’s Thyroiditis Minimizes Lymph Node Metastasis in BRAF Mutant Papillary Thyroid Carcinomas

Author

Issa, Peter P., primary, Omar, Mahmoud, additional, Buti, Yusef, additional, Issa, Chad P., additional, Chabot, Bert, additional, Carnabatu, Christopher J., additional, Munshi, Ruhul, additional, Hussein, Mohammad, additional, Aboueisha, Mohamed, additional, Shama, Mohamed, additional, Corsetti, Ralph L., additional, Toraih, Eman, additional, and Kandil, Emad, additional

Published
2022
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3. Association Between Surgery Preference and Receipt in Ductal Carcinoma In Situ After Breast Magnetic Resonance Imaging

Author

Fazeli, Soudabeh, primary, Snyder, Bradley S., additional, Gareen, Ilana F., additional, Lehman, Constance D., additional, Khan, Seema A., additional, Romanoff, Justin, additional, Gatsonis, Constantine A., additional, Corsetti, Ralph L., additional, Rahbar, Habib, additional, Spell, Derrick W., additional, Blankstein, Kenneth B., additional, Han, Linda K., additional, Sabol, Jennifer L., additional, Bumberry, John R., additional, Miller, Kathy D., additional, Sparano, Joseph A., additional, Comstock, Christopher E., additional, Wagner, Lynne I., additional, and Carlos, Ruth C., additional

Published
2022
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5. Preoperative Breast MRI for Newly Diagnosed Ductal Carcinoma in Situ: Imaging Features and Performance in a Multicenter Setting (ECOG-ACRIN E4112 Trial)

Author

Chou, Shinn-Huey S., primary, Romanoff, Justin, additional, Lehman, Constance D., additional, Khan, Seema A., additional, Carlos, Ruth, additional, Badve, Sunil S., additional, Xiao, Jennifer, additional, Corsetti, Ralph L., additional, Javid, Sara H., additional, Spell, Derrick W., additional, Han, Linda K., additional, Sabol, Jennifer L., additional, Bumberry, John R., additional, Gareen, Ilana F., additional, Snyder, Bradley S., additional, Gatsonis, Constantine, additional, Wagner, Lynne I., additional, Wolff, Antonio C., additional, Miller, Kathy D., additional, Sparano, Joseph A., additional, Comstock, Christopher E., additional, and Rahbar, Habib, additional

Published
2021
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6. Predictors of surgery preference and quality of life in DCIS after breast MRI: A trial of the ECOG-ACRIN Cancer Research Group (E4112).

Author

Fazeli, Soudabeh, primary, Snyder, Bradley, additional, Gareen, Ilana F., additional, Lehman, Constance Dobbins, additional, Khan, Seema Ahsan, additional, Romanoff, Justin, additional, Gatsonis, Constantine, additional, Corsetti, Ralph L, additional, Rahbar, Habib, additional, Spell, Derrick W., additional, Blankstein, Kenneth Bruce, additional, Han, Linda K., additional, Sabol, Jennifer L., additional, Bumberry, John R, additional, Miller, Kathy, additional, Sparano, Joseph A., additional, Comstock, Christopher, additional, Wagner, Lynne I., additional, and Carlos, Ruth, additional

Published
2021
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11. Association of Magnetic Resonance Imaging and a 12-Gene Expression Assay With Breast Ductal Carcinoma In Situ Treatment

Author

Lehman, Constance D., primary, Gatsonis, Constantine, additional, Romanoff, Justin, additional, Khan, Seema A., additional, Carlos, Ruth, additional, Solin, Lawrence J., additional, Badve, Sunil, additional, McCaskill-Stevens, Worta, additional, Corsetti, Ralph L., additional, Rahbar, Habib, additional, Spell, Derrick W., additional, Blankstein, Kenneth B., additional, Han, Linda K., additional, Sabol, Jennifer L., additional, Bumberry, John R., additional, Gareen, Ilana, additional, Snyder, Bradley S., additional, Wagner, Lynne I., additional, Miller, Kathy D., additional, Sparano, Joseph A., additional, and Comstock, Christopher, additional

Published
2019
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13. Factors That Predict Biological Aggressiveness in Estrogen Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative/Lymph Node-Negative Breast Cancer.

Author

Arthur, Lauren E., McMann, Ashley H., Slattery, Lauren N., Fuhrman, George M., Mackey, Aimee M., Rivere, Amy E., and Corsetti, Ralph L.

Subjects
EPIDERMAL growth factor receptors, BREAST cancer
Abstract

Background: Traditionally, breast cancer is staged using TNM criteria: tumor size (T), nodal status (N), and metastasis (M). The Oncotype DX assay provides a recurrence score (RS) based on genomics that predicts the likelihood of distant recurrence in estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-)/lymph node-negative (LN-) tumors. Methods:We retrospectively reviewed themedical records of patients with ER+/HER2-/LN- breast cancer tumorswhowere evaluated between 2007 and 2017 with Oncotype DX RS. We compared the RS to tumor size, patient age, progesterone receptor (PR) status, and LN immunohistochemistry to assess for factors that may independently predict recurrence risk. We also compared tumor size to tumor grade. Results: The data set included 296 tumors: 248 ER+/PR-positive (PR+)/HER2- and 48 ER+/PR-negative (PR-)/HER2-. RS ranged from 0 to 66, patient age ranged from 33 to 77 years, and tumor size ranged from 1 to 65 mm. No significant correlation was found between age and RS (r=-0.073, P=0.208). PR- tumors had a significantly higher RS regardless of size (PR- mean RS 30.8 ± 12.7; PR+ mean RS 16.3 ± 7.3; t(53)=7.6, P<0.0001). No significant correlation was seen between tumor size and RS for all tumors (r=-0.028, P=0.635), and this finding remained true for the PR+tumor subgroup (r=0.114, P=0.072). However, a significant negative correlation was seen between tumor size and RS in the PR- subgroup (r=-0.343, P=0.017). Further analysis to ensure that differences in tumor grade did not account for this correlation showed equal distribution of well differentiated, moderately differentiated, and poorly differentiated tumors with no significant correlation between tumor size and grade. Conclusion: Increasing tumor size may not be associated with increasing biological aggressiveness. Traditionally, smaller tumors are thought to be lower risk and larger tumors higher risk, with a tendency to use chemotherapy with large tumors. However, our data showed a negative correlation between tumor size and RS in the PR- subgroup. A tumor with PR negativity that reaches a large size without metastasizing may suggest a favorable tumor biology. These tumors may not receive as much benefit from chemotherapy as previously thought. Also, the higher RS seen in smaller PR- tumors may demonstrate PR- status as a predictor for higher risk of distant recurrence. We propose that all tumors meeting the ER+/PR-/LN- criteria, regardless of size, should be considered for genotyping, with the RS used to guide chemotherapy benefit. [ABSTRACT FROM AUTHOR]

Published
2020
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15. Prospective study of magnetic resonance imaging (MRI) and multiparameter gene expression assay in ductal carcinoma in situ (DCIS): A trial of the ECOG-ACRIN Cancer Research Group (E4112).

Author

Khan, Seema Ahsan, primary, Gatsonis, Constantine, additional, Snyder, Brad, additional, Lehman, Constance D, additional, Sparano, Joseph A., additional, Solin, Lawrence J., additional, Badve, Sunil S., additional, Corsetti, Ralph L, additional, Rahbar, Habib, additional, Spell, Derrick W, additional, Blankstein, Kenneth Bruce, additional, Han, LInda K, additional, Sabol, Jennifer L., additional, Bumberry, John R, additional, Miller, Kathy D., additional, and Comstock, Christopher, additional

Published
2017
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18. Peritoneal Encapsulation With Incarcerated Meckel Diverticulum Contributing to Small Bowel Obstruction.

Author

Robbins, Keenan J., Kooperkamp, Hannah Z., and Corsetti, Ralph L.

Subjects
MECKEL diverticulum, BOWEL obstructions, EMBRYOLOGY, HUMAN abnormalities, DIVERTICULUM
Abstract

Background: Meckel diverticulum is the most common congenital gastrointestinal malformation, but it is rarely symptomatic. Peritoneal encapsulation is a rare abnormality of embryonic development and may present with obstruction, although it too is usually asymptomatic. Case Report: We report the case of an 82-year-old male who presented with symptoms and imaging findings consistent with small bowel obstruction. During laparotomy, a peritoneal encapsulationwas observed containing the majority of the small bowel. AMeckel diverticulum was discovered tethered to the small bowelmesentery by amesodiverticular band, preventing egress from the accessory peritoneal membrane and appearing to be the cause of the obstruction. Conclusion: This patient had 3 rare findings--peritoneal encapsulation, Meckel diverticulum, and a mesodiverticular band-- contributing to cause an acute small bowel obstruction. The presence of all of these features in one patient is extremely rare, and we believe this is the first description of such a phenomenon. [ABSTRACT FROM AUTHOR]

Published
2019
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23. A Case of Malignant Pheochromocytoma Presenting 7 Years After the Initial Surgery.

Author

Al-Omaishi L, Babin J, and Corsetti RL

Abstract

Background: Pheochromocytoma (PHEO) is a rare tumor of the adrenal medulla and sympathetic ganglion that produces the catecholamines norepinephrine and epinephrine. Traditionally, approximately 10% of PHEOs were thought to be malignant, but recent developments in PHEO research have noted that specific genetic mutations are associated with higher risk of metastatic spread., Case Report: We report the case of a 71-year-old female who presented with abdominal pain in September 2009 when she was 64 years old. Evaluation at that time revealed cholelithiasis and bilateral adrenal masses. Workup showed elevated free normetanephrines, and positron emission tomography-computed tomography demonstrated bilateral adrenal hypermetabolic lesions concerning for malignancy. She underwent open bilateral adrenalectomies and cholecystectomy. The right adrenal mass was identified as a PHEO with nonaggressive features and negative margins, and the left adrenal mass was an adrenal cortical adenoma without dysplasia. In April 2016, the patient was referred by her endocrinologist for elevated blood pressure and 16-lb weight loss. The patient reported weakness, headaches, hot flashes, cold sweats, and fatigue. Laboratory workup revealed elevated plasma free normetanephrine, and imaging showed a recurrence of the PHEO in both the right adrenal bed and the head of the right humerus., Conclusion: Current predictors of PHEO recurrence failed to identify the original tumor as aggressive or likely to return as a metastatic lesion. Because of the rarity of these tumors, few consistent laboratory or radiologic predictors of malignancy based on initial presentation have been identified; predictors of malignancy in PHEO warrant further investigation.

Published
2017

24. Rosai-Dorfman disease of the breast and parotid gland.

Author

Dahlgren M, Smetherman DH, Wang J, and Corsetti RL

Subjects
Breast Diseases pathology, Breast Diseases surgery, Female, Histiocytosis, Sinus pathology, Histiocytosis, Sinus surgery, Humans, Lymph Nodes surgery, Middle Aged, Parotid Diseases pathology, Parotid Diseases surgery, Breast Diseases diagnosis, Histiocytosis, Sinus diagnosis, Lymph Nodes pathology, Parotid Diseases diagnosis, Parotid Gland pathology
Abstract

Rosai-Dorfman disease or sinus histiocytosis with massive lymphadenopathy (SHML) is a histiocytic proliferative disorder that typically involves the cervical lymph nodes with or without extranodal involvement of the skin, soft tissues, respiratory tract, or virtually any other site of the body. We present a case report of SHML involving the cervical lymph nodes, parotid gland and breast. There is only one other Rosai-Dorfman registered case that involves both breast and parotid disease and no previously published case reports. The patient presented atypically with breast masses found on screening mammogram rather than massive cervical lymphadenopathy. We describe the subsequent radiographic and surgical pathologic evidence that led to the diagnosis of this rare disease.

Published
2008

25. Omental torsion mimicking acute appendicitis: a case report.

Author

Kies D, Garcia-Covarrubias L, and Corsetti RL

Subjects
Acute Disease, Adult, Appendectomy, Diagnosis, Differential, Humans, Infarction etiology, Laparoscopy, Male, Peritoneal Diseases complications, Peritoneal Diseases surgery, Torsion Abnormality complications, Torsion Abnormality diagnosis, Torsion Abnormality surgery, Treatment Outcome, Appendicitis, Omentum blood supply, Omentum surgery, Peritoneal Diseases diagnosis
Abstract

Primary omental torsion is an uncommon cause of an acute abdomen that can mimic acute appendicitis. Herein we report a case of suspected acute appendicitis that proved to be a distal segment of infarcted omentum secondary to primary torsion.

Published
2006

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