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4. Antifungal and Cytotoxic 2-Acylcyclohexane-1,3-diones from Peperomia alataand P. trineura

Author

Ferreira, Edgard A., Reigada, Juliana B., Correia, Mauro V., Young, Maria C. M., Guimarães, Elsie F., Franchi, Gilberto C., Nowill, Alexandre E., Lago, João H. G., Yamaguchi, Lydia F., and Kato, Massuo J.

Abstract

Bioactivity-guided fractionation of the separate CH2Cl2extracts from the aerial parts of Peperomia alataand P. trineurayielded seven polyketides: alatanone A [3-hydroxy-2-(5′-phenylpent-4′E-enoyl)cyclohex-2-en-1-one, 1a] and alatanone B [3-hydroxy-2-(3′-phenyl-6′-methylenedioxypropanoyl)cyclohex-2-en-1-one, 2a] from P. alataand trineurone A [3-hydroxy-2-(11′-phenylundec-10′E-enoyl)cyclohex-2-en-1-one, 1b], trineurone B [3-hydroxy-2-(15′-phenyl-18′-methylenedioxypentadecanoyl)cyclohex-2-en-1-one, 2b], trineurone C [3-hydroxy-2-(17′-phenyl-20′-methylenedioxyheptadecanoyl)cyclohex-2-en-1-one, 2c], trineurone D [3-hydroxy-2-(hexadec-10′Z-enoyl)cyclohex-2-en-1-one, 3a], and trineurone E [(6R)-(+)-3,6-dihydroxy-2-(hexadec-10′Z-enoyl)cyclohex-2-en-1-one, 3b] from P. trineura. The isolated compounds were evaluated for antifungal activity against Cladosporium cladosporioidesand C. sphaeospermumand for cytotoxicity against the K562 and Nalm-6 leukemia cell lines.

Published
2014
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