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2. Revisiting the jumping to conclusions bias in functional movement disorders.

Author

Sainz-Amo, Raquel, Morillo-González, Jessenia, Gómez-Corral, Jorge, Moreno, Cristina, Alonso Cánovas, Araceli, Martinez Castrillo, Juan Carlos, Edwards, Mark J., Hernández-Huerta, Daniel, and Pareés, Isabel

Subjects
PARKINSON'S disease, GAIT disorders, MULTIPLE regression analysis, ATTENTION control, NEUROLOGICAL disorders, DELUSIONS, MYOCLONUS, MOVEMENT disorders
Published
2024
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3. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Arnold, Forest, Peyrani, Paula, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Jr., Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Lopardo, Gustavo, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Gnoni, Martin, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, Mendoza, Myrna, Feldman, Charles, Arnold, Forest W., Wiemken, Timothy L., Kelley, Robert, Mattingly, William A., Maurici, Rosemeri, and Ramirez, Julio A.

Published
2018
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4. Towards an Agent-Based Methodology for Developing Agro-Ecosystem Simulations

Author

Corral, Jorge, Calegari, Daniel, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Barthe, Gilles, editor, Pardo, Alberto, editor, and Schneider, Gerardo, editor

Published
2011
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6. Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the CASTLE study

Author

Molina, Jean-Michel, Andrade-Villanueva, Jaime, Echevarria, Juan, Chetchotisakd, Ploenchan, Corral, Jorge, David, Neal, Moyle, Graeme, Mancini, Marco, Percival, Lisa, Yang, Rong, Thiry, Alexandra, and McGrath, Donnie

Published
2008
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10. FOCUS 2: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia

Author

Low, Donald E., File, Thomas M., Jr, Eckburg, Paul B., Talbot, George H., David Friedland, H., Lee, Jon, Llorens, Lily, Critchley, Ian A., Thye, Dirk A., Corral, Jorge, Giugno, Eduardo, Gonzalez Arzac, Maria del Rosario, Maurizi, Diego, Altclas, Javier, Ambasch, Germán, Jasovich, Abel, Minguez, Angel Ramon, Oliva, Maria Eugenia, Teglia, Osvaldo, Bergallo, Carlos, Mastruzzo, Maria Antonia, Isabel Morera, Graciana, Scapellato, Pabio Gustavo, Lamberghini, Ricardo, Mykietiuk, Analia, Remolif, Christian, Barros Monge, Manuel Jose, Enriqueta Campos Barker, Maria Isabel, Chernilo Steinmann, Sara Mireya, Gaete Gutierrez, Pablo Antonio, Muñoz Vejar, Sylvia Susana, Calvo Arellano, Mario Andres, Chahin Anania, Carolina Eugenia, Jauregui Cruz, Arturo, Amaya Tapia, Gerardo, Acuna Kaldman, Moises, Noriega, Eduardo, Matos Prado, Eduardo Demetrio, Ramos, Carlos, Andreeva, Irina, Abyshev, Rashad, Antonovsky, Yuri A., Balyuzek, Marina, Esina, Alla L., Gorelov, Alexander, Khrustalev, Oleg A., Kozlov, Roman S., Novozhenok, Vladislav, Popova, Veronika B., Sobchenko, Svetlana, Trofimov, Vasily, Yakovlev, Sergey, Zhidkov, Konstantin, Ambert, Luminta Gabriela, Fierbinteau, Carmen Georgeta, Ionescu, Valentina, Muresan, Mihai Marius, Tanaseanu, Cristina Mihaela, Georgiev, Ognian, Hodzhev, Valdimir, Marinov, Rosen, Metev, Hristo, Peneva, Marinka, Popov, Dimitar, Simeonova, Milkana, Krastins, Ivars, Lovcinovsk, Viktors, Silins, Viesturs, Svarcberga, Vita, Bargon, Joachim, Bauer, Thorsten, Bergmann, Rolf, Meyer, F.J., Mueller, Thomas, Welte, Tobias, Glaeser, Sven, Hammerl, Peter, Kern, Hartmut, Krueger, Stefan, Kujath, Peter, Lies, Achim, Schaberg, Tom, Schmalz, Oliver, Schütte, Wolfgang, Chazan, Ryszarda, Górecka, Dorota, Rogala, Barbara, Antczak, Adam, Grodzicki, Tomasz, JahnzRö, Karina, Milanowski, Janusz, Nalepa, Piotr, Wróbel-Rajzer, Malgorzata, Szelerska-Twardosz, Hanna, GrzelewskaRzymowska, Iwona, Kachel, Tomasz, Marciniak, Andrzej, Panaszek, Bernard, Szczeklik, Andrzej, Kozielski, Jerzy, Harat, Rafal, Jastrzebsk, Dariusz, Juszczak, Jacek, Labij, Violetta, Vetter, Norbert, Bolitschek, Josef, Eckmayr, Josef, Molnár, Sándor, Pápai-Székely, Zsolt, Szegedi, Janos, Vinkler, Ilona, Borscchivskyy, Mykhaylo, Dziublyk, Oleksandr, Dzyak, Georgiy V., Kraydaschenko, Oleg, Mostovoy, Yuriy M., Rudyk, Iurii S., Sushko, Viktor, Vizir, Vadim, Bhattacharya, Amal Kumar, Chakrapan, Mahabala, DʼSouza, George, Malpani, G.S., Mehta, Parthiv, Rao, K.N. Mohar, and Talwar, Deepak

Published
2011
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11. ¿Influyen el sexo y el temperamento en los cambios en la expresividad emocional de infantes chilenos? Un estudio longitudinal.

Author

Corral, Jorge, Mahns, Colomba, Pereira, Fernanda, Coloma, Carolina, Avilés, Javiera, and Farkas, Chamarrita

Subjects
EMOTIONS, FRUSTRATION, TEMPERAMENT, PLEASURE, SOCIALIZATION
Abstract

Copyright of Journal of Psychology (UNLP) / Revista de Psicología (UNLP) is the property of Facultad de Psicologia Universidad Nacional de La Plata and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

12. Macrolide therapy is associated with lower mortality in community-acquired bacteraemic pneumonia

Author

Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, Mendoza, M, Arnold, Forest W., Lopardo, Gustavo, Wiemken, Timothy L., Kelley, Robert, Peyrani, Paula, Mattingly, William A., Feldman, Charles, Gnoni, Martin, Maurici, Rosemeri, Ramirez, Julio A., Arnold, Forest, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, Mendoza, Myrna, Arnold, F, Lopardo, G, Wiemken, T, Kelley, R, Peyrani, P, Mattingly, W, Feldman, C, Gnoni, M, Maurici, R, Ramirez, J, Ayesu, K, File, T, Burdette, S, Blatt, S, Restrepo, M, Bordon, J, Gross, P, Musher, D, Marrie, T, Weiss, K, Roig, J, Lode, H, Welte, T, Aliberti, S, Blasi, F, Cosentini, R, Legnani, D, Franzetti, F, Montano, N, Cervi, G, Rossi, P, Voza, A, Ostrowsky, B, Pesci, A, Nava, S, Viale, P, Galavatti, V, Patricia, A, Dimas, C, Piro, R, Viscoli, C, Torres, A, Valenti, V, Ojales, D, Bodi, M, Porras, J, Rello, J, Menendez, R, Stolz, D, Schuetz, P, Haubitz, S, Chalmers, J, Fardon, T, Benchetrit, G, Rodriguez, E, Corral, J, Gonzalez, J, de Vedia, L, Luna, C, Martinez, J, Marzoratti, L, Rodriguez, M, Videla, A, Saavedra, F, Lopez, H, Victorio, C, Riera, F, Jimenez, P, Fernandez, P, Parada, M, Fuenzalida, A, Riquelme, R, Barros, M, Luna, J, Toala, I, Oze de Morvil, G, Fernandez, R, Aiello, G, Alvarez, P, Soca, A, Arteta, F, Delgado, J, Levy, G, Rivero, L, Rodriguez, B, Mirabal, M, Mateo, M, Mendoza, M, Arnold, Forest W., Lopardo, Gustavo, Wiemken, Timothy L., Kelley, Robert, Peyrani, Paula, Mattingly, William A., Feldman, Charles, Gnoni, Martin, Maurici, Rosemeri, Ramirez, Julio A., Arnold, Forest, Ramirez, Julio, Ayesu, Kwabena, File, Thomas, Burdette, Steven, Blatt, Stephen, Restrepo, Marcos, Bordon, Jose, Gross, Peter, Musher, Daniel, Marrie, Thomas, Weiss, Karl, Roig, Jorge, Lode, Harmut, Welte, Tobias, Aliberti, Stephano, Blasi, Francesco, Cosentini, Roberto, Legnani, Delfino, Franzetti, Fabio, Montano, Nicola, Cervi, Giulia, Rossi, Paolo, Voza, Antonio, Ostrowsky, Belinda, Pesci, Alberto, Nava, Stefano, Viale, Pierluigi, Galavatti, Vanni, Patricia, Aruj, Dimas, Carlos, Piro, Roberto, Viscoli, Claudio, Torres, Antoni, Valenti, Vincenzo, Ojales, Daniel Portela, Bodi, Maria, Porras, Jose, Rello, Jordi, Menendez, Rosario, Stolz, Daiana, Schuetz, Philipp, Haubitz, Sebastian, Chalmers, James, Fardon, Tom, Benchetrit, Guillermo, Rodriguez, Eduardo, Corral, Jorge, Gonzalez, Jose, de Vedia, Lautaro, Luna, Carlos, Martinez, Jorge, Marzoratti, Lucia, Rodriguez, Maria, Videla, Alejandro, Saavedra, Federico, Lopez, Horacio, Victorio, Carlos, Riera, Fernando, Jimenez, Patricio, Fernandez, Patricia, Parada, Maria, Fuenzalida, Alejandro Díaz, Riquelme, Raul, Barros, Manuel, Luna, Juan Manuel, Toala, Ivan, Oze de Morvil, Guillermo Arbo, Fernandez, Ricardo, Aiello, Gonzalo, Alvarez, Pablo, Soca, Ana, Arteta, Federico, Delgado, Jose, Levy, Gur, Rivero, Ludwig, Rodriguez, Benito, Mirabal, Mario Perez, Mateo, Marilyn, and Mendoza, Myrna

Abstract

Background: Community-acquired pneumonia (CAP) has a potential complication of bacteremia. The objective of this study was to define the clinical outcomes of patients with CAP and bacteremia treated with and without a macrolide. Materials and methods: Secondary analysis of the Community-Acquired Pneumonia Organization database of hospitalized patients with CAP. Patients with a positive blood culture were categorized based on the presence or absence of a macrolide in their initial antimicrobial regimen, and severity of their CAP. Outcomes included in-hospital all-cause mortality, 30-day mortality, length of stay, and time to clinical stability. Results: Among 549 patients with CAP and bacteremia, 247 (45%) were treated with a macrolide and 302 (55%) were not. The primary pathogen was Streptococcus pneumoniae (74%). Poisson regression with robust error variance models were used to compare the adjusted effects of each study group on the outcomes. The unadjusted 30-day mortality was 18.4% in the macrolide group, and 29.6% in the non-macrolide group (adjusted relative risk (aRR)0.81; 95% confidence interval (CI)0.50–1.33; P = 0.41). Unadjusted in-hospital all-cause mortality was 7.3% in the macrolide group, and 18.9% in the non-macrolide group (aRR 0.54, 95% CI 0.30–0.98; P = 0.043). Length of stay and time to clinical stability were not significantly different. Conclusions: In-hospital mortality, but not 30-day mortality, was significantly better in the macrolide group. Our data support the use of a macrolide in hospitalized patients with CAP and bacteraemia

Published
2018

13. La visión del alumnado de educación física: 5º y 6º de educación primaria del colegio Compañía de María (Zaragoza)

Author

Carilla Corral, Jorge and Canales Lacruz, María Inmaculada

Abstract

En el presente trabajo se analiza la visión del alumnado de Educación Física en los cursos 5º y 6º de Educación Primaria del colegio Compañía de María (Zaragoza). Para ello, se ha elaborado un cuestionario dirigido a este alumnado. Ahí se tratan diferentes dimensiones como Recibir, Responder, Valorar, Organización, Caracterización y Dificultad. Los resultados obtenidos reflejan que el alumnado valora positivamente la asignatura, mostrando interés durante el desarrollo de las clases. Este interés es reflejado en su actitud, su predisposición a atender, su participación, animando a sus compañeros y trabajando duro. Además, no se manifiestan grandes diferencias entre cursos ni entre géneros.

Published
2017

14. Modelización de una explotación ganadera extensiva criadora en basalto

Author

Dieguez, Francisco, Bommel, Pierre, Corral, Jorge, Bartaburu, Danilo, Pereira, Marcelo, Montes, Esteban, Duarte, Emilio, and Morales, Hermes

Subjects
Agriculteur, P40 - Météorologie et climatologie, Ocean Engineering, Facteur climatique, Sécheresse, L02 - Alimentation animale, Bovin, Élevage extensif, U10 - Informatique, mathématiques et statistiques, L01 - Élevage - Considérations générales, Sol basaltique, Pâturages, Participation, General Engineering, Modèle de simulation, Apprentissage, approches participatives, Conduite des herbages, U30 - Méthodes de recherche, système d'aide à la décision
Abstract

Los modelos de simulación pueden ser considerados como herramientas de aprendizaje –según la idea del «simulador de vuelo»– donde los usuarios se beneficiarían por experimentar con situaciones posibles, más aún si son construidos en forma participativa con los potenciales interesados. El Instituto Plan Agropecuario (IPA) desarrolló un modelo para representar a una explotación ganadera criadora extensiva sobre un suelo representativo de basalto: el MEGanE (Modelo de una Explotación Ganadera Extensiva). Los resultados de la simulación, tanto fitotécnicos como zootécnicos muestran gran coherencia con resultados de investigación nacional. Asimismo, el MEGanE pudo reproducir una situación de crisis forrajera conocida, con resultados coherentes a una realidad posible. El MEGanE fue diseñado para transmitir conceptos, con términos de fácil comprensión por los usuarios.

Published
2012

16. Modelización de una explotación ganadera extensiva criadora en basalto

Author

Dieguez Cameroni, Francisco, Bommel, Pierre, Corral, Jorge, Bartaburu, Danilo, Pereira, Marcelo, Montes, Esteban, Duarte, Emilio, and Morales Grosskopf, Hermes

Subjects
MODEL, EXTENSIVE BEEF PRODUCTION, SIMULACIÓN, BASALTIC SOILS, SIMULATION, BASALTO, MODELO, GANADERÍA EXTENSIVA
Abstract

Los modelos de simulación pueden ser considerados como herramientas de aprendizaje –según la idea del «simulador de vuelo»– donde los usuarios se beneficiarían por experimentar con situaciones posibles, más aún si son construidos en forma participativa con los potenciales interesados. El Instituto Plan Agropecuario (IPA) desarrolló un modelo para representar a una explotación ganadera criadora extensiva sobre un suelo representativo de basalto: el MEGanE (Modelo de una Explotación Ganadera Extensiva). Los resultados de la simulación, tanto fitotécnicos como zootécnicos muestran gran coherencia con resultados de investigación nacional. Asimismo, el MEGanE pudo reproducir una situación de crisis forrajera conocida, con resultados coherentes a una realidad posible. El MEGanE fue diseñado para transmitir conceptos, con términos de fácil comprensión por los usuarios. Simulation models can be considered as learning tools, according to the idea of «flight simulator», where users would benefit by experimenting with possible realities, even more if they are built with the potential stakeholders in a participatory way. The IPA (Agricultural Planning Institute) developed a model to represent an extensive breeder cattle farm on a representative basaltic soil: the MEGanE (Model of an Extensive Stock Breeding Farm). The results of the simulation, both for forage production and zootechnics, show great consistency with national research information. Also, the MEGanE was able to reproduce a known drought crisis, with results consistent with a possible reality. The MEGanE has been designed to exchange concepts, with variables easily understood by potential users

Published
2012

17. Productive and Reproductive results of the simulation of an extensive livestock farm: an analysis of the effect of the grass availability and stocking rate

Author

Dieguez, Francisco, Bommel, Pierre, Corral, Jorge, Bartaburu, Danilo, Pereira, Marcelo, Montes, Esteban, Duarte, Emilio, and Grosskopf, Hermes Morales

Subjects
Ferme pilote, Herbage, Performance de reproduction, L52 - Physiologie animale - Croissance et développement, Disponibilité alimentaire, L53 - Physiologie animale - Reproduction, Performance animale, L02 - Alimentation animale, Bovin, Élevage extensif, Fourrage, Sol basaltique, Pâturages, Modèle de simulation, U30 - Méthodes de recherche
Abstract

This work presents productive and reproductive results of the simulations made with an extensive livestock farm model on basaltic soils. The scenari were constructed varying the initial grass height (GH) and the system stocking rate (SR). The model is chaotic, dynamic, empirical and deterministic. It was built in a participatory way with a group of local stakeholders of the basaltic region of the country (Uruguay). A simplified version of it was utilized, where only one parcel and only one animal category were simulated each time. No adaptive management was implemented into the simulation process. These models represent a Breeding (Br) and a Rearing (Re) extensive systems, where the exclusive feed source is the natural pasture. All scenari were simulated with average pasture growth, estimated by satellite remote sensing for the series 2000-2010, for a representative farm basaltic region. Annual results of pregnancy rate and live weight gain per animal were the two main outputs analyzed for the Br and Re simulated systems, respectively. In the scenari building the two input variables changed stepwise were the initial GH (going from 2 to 12 cm) as indicator of the forage availability, and the initial number of animals (going from 0.1 to 1.9 animal/ha) as indicator of the SR. The initial situation for the Br simulation was cows of 360 kg of average live weight. The start of the simulation was at the beginning of autumn, and the calving and mating seasons were spring and summer, respectively. For the Re simulation, the initial situation was defined by heifers with an average live weight of 150 kg. Simulation started also at the beginning of autumn. For the Br simulations results of pregnancy rates higher than 80% are only achieved in the scenari of low and mean SR ( 10 cm). If the initial GH on autumn is 5 cm, to achieve that pregnancy rate level, the SR must be less than 0.9 cows/ha. For the Re simulation, results of gain per animal bigger than 100 kg/heifer are attained in a continuum of situations going from 3 cm and 0.1 animals/ha to 12 cm and 1.5 animals/ha. The results of simulation are consistent with the real situations on basaltic soils, showing that low forage availability (< 5 cm in silico) in the early autumn combined with a high SR (> 0.9 animals/ha in silico) compromise seriously the productive and reproductive performances of the system.

Published
2012

18. Simulaciones para apoyo en la toma de decisiones, el Aprendizaje y la Adaptación

Author

Morales, Hermes, Bartaburu, Danilo, Dieguez, Francisco, Corral, Jorge, Bommel, Pierre, and Pereira, Marcelo

Subjects
U10 - Informatique, mathématiques et statistiques, L01 - Élevage - Considérations générales
Abstract

El uso de simulaciones permite el manejo de grandes cantidades de información de distinto origen y ello puede mejorar las decisiones y hacerlas más pertinentes. Desde hace algunos años se han concretado las posibilidades de simular sistemas complejos, en forma dinámica, espacialmente explícita e integrando información cualitativa por medio de sistemas multiagentes y otros tipos de simulaciones que integran al menos alguna de estas características, y permiten explorar la evolución de estos sistemas en distintos escenarios. Al mismo tiempo se ha enfatizado la necesidad de aumentar la capacidad de adaptación de los productores y de las cadenas productivas al aumento de variabilidad climática que se prevé tenga lugar en los próximos decenios. Esto tiene especial relevancia en socio-eco-sistemas donde innumerables variables que tienen su propia dinámica interaccionan de una forma intrincada. En este trabajo se describen dos modelos que simulan la ganadería en el Norte del Uruguay a nivel de explotaciones. Ambos han considerado la participación de involucrados externos al proyecto, sea en cuanto a examinar la estructura y la dinámica de la simulación, sea en contrastar los resultados contra su experiencia. El primero de ellos, Arapey, compara distintas estrategias de ganaderos entre los años 1970 y 2004 y SequiaBasalto simula las interacciones entre el crecimiento del pasto y el desempeño animal cuando se aplican distintas estrategias, teniendo en cuenta la dinámica estacional y la variabilidad climática. Se muestran avances hacia simulaciones disponibles en la web con distintos formatos según los usuarios a los que se apunta y se discute su uso como herramientas de aprendizaje y de fomento de la capacidad de adaptación.

Published
2012

20. One more step towards participatory modeling. Involving local stakeholders in designing scientific models for participative foresight studies

Author

Bommel, Pierre, Dieguez, Francisco, Morales, Hermes, Bartaburu, Danilo, Duarte, Emilio, Montes, Esteban, Pereira, Marcelo, and Corral, Jorge

Subjects
Changement climatique, Agriculteur, P40 - Météorologie et climatologie, L01 - Élevage - Considérations générales, Participation, Modèle de simulation, Élevage, Sécheresse, approches participatives, U30 - Méthodes de recherche, Pastoralisme
Abstract

This paper focuses on the collective design and immediate execution of an agent-based model (ABM) by dynamically interpreting activity diagrams of agent behaviors. To reach this objective, we have implemented an ABM of livestock producers facing drought conditions in Uruguay. The first step consists in implementing a standard ABM with pasture growth, herd dynamics and simple agents roughly imitating farmers' strategies. The second step is more participative since it consists in assessing the model with the real cattle farmers. As it appears in a majority of modeling processes, this evaluation phase requires feedback on model design. In order to make this assessment more lively and efficient, we have conceived a tool for drawing diagrams and interpreting them immediately. Thanks to this new opportunity, the actors have quickly understood how the model worked and were able to criticize and modify it. Thus, this innovative modeling tool enables the involvement of stakeholders in co-designing ABM for participatory foresight studies. We hope it will facilitate the emergence of new and more efficient practices for farm management that account for climate changes.

Published
2011

21. A further step towards participatory modelling. Fostering stakeholder involvement in designing models by using executable UML

Author

Bommel, Pierre, Dieguez, Francisco, Bartaburu, Danilo, Duarte, Emilio, Montes, Esteban, Pereira Machín, Marcelo, Corral, Jorge, Pereira de Lucena, Carlos José, Morales, Hermes, Bommel, Pierre, Dieguez, Francisco, Bartaburu, Danilo, Duarte, Emilio, Montes, Esteban, Pereira Machín, Marcelo, Corral, Jorge, Pereira de Lucena, Carlos José, and Morales, Hermes

Abstract

This paper focuses on the collective design and immediate execution of an agent-based model (ABM) by dynamically interpreting the activity diagrams of agent behaviours. To reach this objective, we have implemented an ABM of livestock producers facing drought conditions in Uruguay. The first step consists in implementing a standard ABM with pasture growth, herd dynamics and simple agents roughly imitating farmers' strategies. The second step is more participative since it consists in assessing the model with the real cattle farmers. As with most modelling processes, this evaluation phase requires feedback on model design. In order to make this assessment more lively and efficient, we have conceived a tool for drawing diagrams that can be immediately interpreted by the agents. Thanks to this new editor, the actors have quickly understood how the model worked and were able to criticize and modify it. Thus, this innovative modelling tool enables the involvement of stakeholders in co-designing ABM for participatory foresight studies. We hope it will facilitate the emergence of new and more efficient practices for farm management that can account for climate changes.

Published
2014

22. Multi-agent systems applied to land use and social changes in Rio de la Plata Basin (South America)

Author

Corral, Jorge, Arbeletche, Pedro, Burges, Julio César, Morales, Hermes, Continanza, Guadalupe, Couderc, Jorge, Courdin, Virginia, and Bommel, Pierre

Subjects
E11 - Économie et politique foncières, E50 - Sociologie rurale, U30 - Méthodes de recherche
Abstract

Dynamics in agrarian systems of Uruguay and Argentina present some positive aspects as well as other potentially devastating. Traditional producers have a production strategy based on looking for a balance between cattle and agriculture production, alternating pasture and crops. A new actor: investment-fund-managers rent the land for agriculture production, and from our team¿s discussions emerged that they follow a strategy similar to that of financial capital: decide what to do in terms of the expected net profit. Economical, ecological and social consequences could be expected. Modeling and simulating with Multi-Agent-Systems was used for exploring the system¿s evolution with the objective of improving our understanding of the agrarian system and to contribute to the envision of possible effects on land use caused by changes in product prices and/or policy changes. The model considers the soil resource as having productive potential and assumes that each traditional producer annually decides whether to change or not its production activity over 25% of its land units or to rent to investment fund managers. A six year database with historical production activity revenues and product¿s prices was used for the simulation, where each simulated year randomly chooses from this database. The first results of these simulations generate questions about the dynamics of the natural resources, challenge the survival of traditional farmers and anticipate landscape changes associated to economic, ecological and social changes. A strong variability was observed from year to year in respect to land use. Results show that if the current price structure is maintained as well as the relation between net profits of agriculture and cattle, then a tendency to expand Investment Fund Managers¿ lands will occur. We conclude that the newly arrived Investment Fund Managers tend to induce a rent activity in traditional producers as well as a substantial increase in agricultural activities (decreasing cattle activities). The historical cattle-agricultural model well known in Uruguay and Argentina has been challenged by market-imposed conditions.The simulation shows that social effects should also be foreseen.

Published
2008

24. Experimentos virtuales para explorar la interacción entre el clima, el crecimiento del campo natural, la performance de un rodeo vacuno y los resultados económicos

Author

Morales, Hermes, Terra, R., Bartaburu, Danilo, Dieguez, Francisco, Pereira, Marcelo, Corral, Jorge, Bommel, Pierre, Montes, Esteban, Duarte, Emilio, Morales, Hermes, Terra, R., Bartaburu, Danilo, Dieguez, Francisco, Pereira, Marcelo, Corral, Jorge, Bommel, Pierre, Montes, Esteban, and Duarte, Emilio

Abstract

Se realizaron una serie de experimentos virtuales usando un modelo multi-agentes que incluye la dinámica i) de la producción estacional del pasto sobre suelos de basalto, ii) de la estructura del rodeo, iii) del comportamiento climático, iv) de las estrategias aplicadas y la interacción entre estas variables. El modelo es determinístico y dinámico, incluye retroacciones y es caótico, para ciertos rangos de los parámetros manifiesta gran sensibilidad a la situación inicial, con régimen cuasi periódico. La estrategia elegida usa como indicador para la toma de decisiones la altura del pasto. Se usan precios promedio del período 2001-2010, a lo largo de cien años. Se descartan los primeros 30 que son de ajuste del sistema. Se estudió la sensibilidad a tres parámetros: 1) carga de ajuste en invierno 0,7 a 1,4 UG/ha, 2) clima medio 0,5 a 1,2 del promedio, 3) amplitud de variabilidad climática interanual, 0 (clima estacionario) a 1 variabilidad simulada con el modelo Century normalizado. El control fue variabilidad interanual nula, carga de ajuste en invierno 0,9 y clima promedio 1999-2008. Las variables anuales de resultado fueron: ganancia, carga media, altura del pasto, condición corporal y porcentaje de parición. Los resultados indican que con clima medio y sin variabilidad climática interanual la variabilidad para todas las variables elegidas se incrementa fuertemente cuando el ajuste de carga invernal se hace por encima de 0,9 UG/ha. Las ganancias crecen hasta ese valor de ajuste - sin variabilidad interanual - y luego se estabilizan aumentando sensiblemente su variabilidad. Cuando se introduce variabilidad climática interanual los resultados reflejan esta variabilidad crecientemente a medida que los ajustes invernales se realizan a cargas mayores, incluyendo crecientemente ganancias negativas y colapsos del sistema. Estrategias rígidas, solo repoblarse a partir de los nacimientos en el predio por ejemplo, son inviables con la variabilidad actual simulada.

Published
2012

27. Modéliser le changement dans la gestion des terres de parcours en Uruguay

Author

Morales, Hermes, Arbeletche, Pedro, Bommel, Pierre, Burges, Julio César, Champredonde, Marcelo, Corral, Jorge, Tourrand, Jean-François, Morales, Hermes, Arbeletche, Pedro, Bommel, Pierre, Burges, Julio César, Champredonde, Marcelo, Corral, Jorge, and Tourrand, Jean-François

Abstract

Du fait de la globalisation des échanges, la société rurale uruguayenne se transforme profondément. Ces changements se répercutent sur l'élevage et la gestion de ses terres de parcours. Au travers d'une modélisation participative fondée sur les systèmes multi-agents, les auteurs présentent les facteurs de changement tels qu'ils sont perçus par les acteurs locaux : l'augmentation du prix des produits agricoles liée à la globalisation des échanges, mais également : l'internationalisation des centres de décision ; l'exode rural et l'attrait de la vie urbaine ; l'émergence des " pools de siembra ", nouveaux acteurs de la vie rurale ; les changements biotechniques et climatiques. Ils montrent que la construction de modèles est également un outil de partage de l'information et de formation des acteurs locaux, et permet en outre de dégager des éléments de politique publique durable.

Published
2010

30. Multicentric Study Of Hospitalized Patients Affected By H1N1 Influenza In Mar Del Plata, Argentina, During The June To August 2009 Period

Author

Corral, Jorge, primary, Aquilia, Silvia, additional, Miglioranza, Cristina, additional, Hualde, Mariana, additional, Corral, Gonzalo, additional, Rosati, Mariela, additional, de Labra, Lucia, additional, Loizaga, Guadalupe, additional, Gimenez, Cristina, additional, Manzo, Alexis, additional, Tiscornia, Mario, additional, Alvo, Ana, additional, Ferro, Alejandro, additional, and Paula, Herrera, additional

Published
2010
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32. Once-Daily Atazanavir/Ritonavir Compared With Twice-Daily Lopinavir/Ritonavir, Each in Combination With Tenofovir and Emtricitabine, for Management of Antiretroviral-Naive HIV-1–Infected Patients: 96-Week Efficacy and Safety Results of the CASTLE Study

Author

Molina, Jean-Michel, primary, Andrade-Villanueva, Jaime, additional, Echevarria, Juan, additional, Chetchotisakd, Ploenchan, additional, Corral, Jorge, additional, David, Neal, additional, Moyle, Graeme, additional, Mancini, Marco, additional, Percival, Lisa, additional, Yang, Rong, additional, Wirtz, Victoria, additional, Lataillade, Max, additional, Absalon, Judith, additional, and McGrath, Donnie, additional

Published
2010
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33. Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count >= 300 cells/mu L who were assigned to 7.5 MIU interleukin-2

Author

Fox, Zoe, Antunes, Francisco, Davey, Rick, Gazzard, Brian, Klimas, Nancy, Labriola, Ann, Losso, Marcelo, Neaton, James D., Phillips, Andrew N., Ruxrungtham, Kiat, Staszewski, Schlomo, Weiss, Laurence, Lundgren, Jens D., Abrams, Donald I., Cooper, David A., Darbyshire, Janet H., Duncan, William R., Emery, Sean, Lane, H. Clifford, Lehrman, Sandra, Aguilar, Liliana, Betina Angel, Eleonora, Aquilia, Silvia, Belloso, Waldo, Benetucci, Jorge, Bittar, Victor, Cahn, Pedro, Casiro, Arnaldo, Contarelli, Jorge, Corral, Jorge, Daciuk, Lucia, David, Daniel, Ferrari, Ines, Fridman, Diego, Galache, Viviana, Guaragna, Graciela, Ivalo, Silvina, Laplume, Hector, Lanusse, Isabel, Lasala, Maria B., Lattes, Roberta, Lasovsky, Jaime, Lopardo, Gustavo, Lourtau, Leonardo, Lupo, Sergio, Maranzana, Aldo, Marson, Cristina, Massera, Lucila, Del Lujan Sanchez, Marisa, Somenzini, Carla, Tocci, Mariel, Algar, Sally, Anderson, Jonathan, Baker, David, Blavius, Kathy, Bloch, Mark, Boyle, Michael, Bradford, David, Britton, Phillip, Carrall, Leah, Carr, Andrew, Chuah, John, Curry, Michael, D Arcy-Evans, Clive, Dobson, Pauline, Doong, Nicholas, Egan, Cari, Ferguson, Wendy, Finlayson, Robert, French, Martyn, Frater, Anthony, Gold, Julian, Habel, Philip, Haig, Kay, Holland, Rohan, Hyland, Natalie, Hoy, Jennifer, Hudson, Jeff, James, Robyn, Leung, Jenny, Lowe, Kaye, Macrae, Karen, Mcmurchie, Marilyn, Medland, Nicholas, Miller, Samantha, Murray, Jo, Newman, Rosie, Orth, David, Patching, Julie, Primrose, Ruth, Ree, Hugo, Richardson, Robyn, Rogers, Gary, Roney, Janine, Roth, Norman, Sarangapany, Jeganathan, Shaw, David, Silberberg, Carol, Skett, Jenny, Williams, Leah, Soo, Tuck Meng, Sowden, David, Street, Alan, Vale, Robyn, Villella, Claudio, Walker, Alan, Watson, Ashley, Wendt, Ngaire, Wood, Helen, Youds, David, Aichelburg, Alexander, Rieger, Armin, Vetter, Norbert, Clumeck, Nathan, Wit, Stephane, Kabeya, Kabamba, O Doherty, Elizabeth, Amorim, Cristiane Sales, Basso, Caritas Relva, Lewi, David Salamao, Pereira, Luiz Carlos, Da Silva, Mariliza, Lobato Souza, Tamara Newman, Angel, Jonathan, Bouchard, Pierrette-Rolande, Clark, Fran, Cohen, Jeff, Dambreville, Mimose, Ellis, Michele, Fiset, Stephan, Foster, Andrea, Fraser, Christopher, Gagnon, Susan, Gilmour, Janet, Guenette, Richard, Haldane, Heather, Hawley-Foss, Nanci, Hyndman, Susan, Johnston, Lynn, Jubinville, Nathalie, Juneau, Francoise, Kelleher, Lynn, Lapointe, Lyne, Latendre-Paquette, Judy, Lindemulder, Adeline, Mashinter, Laura, Lefebvre, Eric, Mcfarland, Nancy, Morisseau, Chantal, O Neill, Robert, Piche, Alain, Ralph, Edward, Rouleau, Danielle, Routy, Jean-Pierre, Sandre, Roger, Schmidt, Shelley, Shafran, Stephen, Smaill, Fiona, Stromberg, Dale, Trepanier, Jean-Marc, Trottier, Sylvie, Veal, Susanne, Walmsley, Sharon, Weiss, Karl, Williams, Kurt, Young, Mavis, Zaleschuk, Barbara, Zarowny, Don, Baadegaard, Bente, Black, Finn, Boedker, Kirsten, Gerstoft, Jan, Jensen, Lene, Mathiesen, Lars, Nielsen, Henrik, Pedersen, Court, Petersen, Dorthe, Aboulker, Jean-Pierre, Baakili, Adyb, Bengrait, Nafissa, Bensalem, Maryse, Berthe, Huguette, Bloche, Martin, Bazin, Claude, Boue, Francois, Bouvet, Elisabeth, Brancon, Christiane, Capitant, Catherine, Ceppi, Carole, Cheneau, Christine, Coutellier, Anne, Chennebault, Jean Marie, Coquet, Fabienne, Truchis, Pierre, Delavalle, Anne-Marie, Frixon-Marin, Veronique, Gastaut, Jean-Albert, Delfraissy, Francois, Eliaszeicz, Muriel, Gallais, Herve, Gataut, Jean-Albert, Gilquin, Jacques, Gonzalez-Canali, Gustavo, Gaudebout, Chrisiane, Goujard, Cecile, Hoen, Bruno, Honore, Patricia, Jarousse, Bernard, Lang, Jean-Marie, Lefebvre, Benedict, Levy, Yves, Loison, Jocelyne, Maignan, Aline, Meynard, Jean-Luc, Michon, Christophe, Mole, Martin, Marsal, Laurence, Matheron, Sophie, Mortier, Emmanuel, Oksenhendler, Eric, Poirier, Sandrine, Picard-Dahan, Catherine, Ravaux, Isabelle, Raffi, Francois, Raguin, Gilles, Reynes, Jacque, Rozenbaum, Willy, Salmon, Dominique, Simon, Anne, Spiridon, Gabriella, Viard, Jean-Paul, Vidal, Michele, Zucman, David, Bergmann, Frank, Brockmeyer, Norbert, Faetkenheuer, Gerd, Fenske, Stefan, Gey, Daniela, Goebel, Frank-Detlef, Goetsch, Martina, Hartmann, Martin, Klinker, Hartwig, Kremer, Gisela, Mantzsch, Kathleen, Mauss, Stefan, Rockstroh, Juergen, Rotty, Jessica, Rund, Ellen, Schneider, Katrin, Schuermann, Dirk, Staszweski, Schlomo, Tilmann, Klaus, Vogel, Martin, Bentwich, Zvi, Drora, Goldstain, Kedem, Eynat, Lang, Ruth, Levi, Itzic, Maayan, Shlomo, Magen, Eli, Mamorsky, Merav, Pilpul, Anat, Pollack, Shimon, Sthoeger, Zev, Vered, Hadas, Yust, Israel, Lyons, Fiona, Mulcahy, Fiona, Rochford, Annette, Auiti, Fernando, Angarano, Gioacchino, Bertelli, Davide, Bini, Teresa, Bruno, Raffaele, Cadeo, Gian Pietro, Carosi, Giampietro, D Arminio Monforte, Antonella, Del Giacco, Sergio, Di Pietro, Massimo, Esposito, Roberto, Filice, Gaetano, Gavazzeni, Gabriella, Guaraldi, Giovanni, Indiveri, Francesco, Lazzarin, Adriano, Mazzotta, Francesco, Minolli, Lorenzo, Montroni, Maria, Moroni, Mauro, Nozza, Silvia, Pastor, Guiseppe, Poli, Guido, Raise, Enzo, Romagnani, Sergio, Rusconi, Vega, Sacchi, Paolo, Suter, Fredy, Tambussi, Giuseppe, Tirelli, Umberto, Fraser, Helen, Iwamoto, Aikichi, Kikuchi, Yoshida, Mori, Masahiko, Nakamura, Tetsuya, Odawara, Takashi, Oka, Shinichi, Shirasaka, Takuma, Takano, Misao, To, Junichiro, Ueta, Chisato, El Filali, Kamal, Erradey, Ikbale, Himmich, Hakima, Blok, W., Borleffs, J., Bravenboer, B., Bronveld, W., Claessen, F., Duurvoort, Maurice, Ferwerda, J., Frissen, P., Hulshoff, Nicolette, Juttman, Job, Kauffmann, R., Koopmans, P., Kroon, F., Lowe, Selwyn, Leemhuis, M., Meenhorst, P., Boer, Lieselotte Posthuma, Reiss, Peter, Reinders-Folmer, S., Richter, C., Santegoets, Rick, Schoemaker, Marijke, Schrey, G., Sprenger, Herman, Ten Veen, Jacob, Tessalaar, Judith, Ende, M., Vall, H., Eeden, Arne, Leeuwen, Remko, Vermeulen, Joost, Ten Kate, Reinier W., Boxtel, Renee, Eden, Arne, Ven, Bernadette, Meulen, Piet, Ten Napei, C., Vriesendrop, R., Bruun, Johann, Bakowska, Elzbieta, Beniowski, Marek, Boron-Kaczmarska, Anna, Gasiorowski, Jacek, Gxadysz, Andrzej, Horban, Andrzej, Knysz, Brygida, Mularska, Elzbieta, Pynka, Magdelena, Szymczak, Aleksandra, Aldir, Isabel, Doroana, Manuela, Duque, Luis, Mansinho, Kamal, Pinto, Inez, Valadas, Emilia, Vera, Jose, Foo, Estelle, Panchalingham, Anushia, Lim, Poh Lian, Paton, Nick, Peperstraete, Bernard, Quek, Angela, Alcazar-Caballero, Rosario, Arrizabalaga, Julio, Bouza, Emilio, Cepeda, Concepcion, Barron, Xabier, Cervero Jimenez, Miguel, Clotet, Bonaventura, Cortes, Luis, Domingo, Pere, Fernandez, Pompeyo, Fernandez-Cruz, Eduardo, Fuster, Montserrat, Gatell, Jose, Gijon, Paloma, Gil, Ignacio, Gonzales-Lahoz, Juan, Gonzalez, Alicia, Hernandez, Manuel, Iribarren, Jose, Jimenez, Miguel, Knobel, Hernando, Leon, Agathe, Carlos Lopez, Juan, Lozano, Angeles, Lopez, Paco, Moreno, Jose, Munoz, Rosa, Padilla, Belen, Parras, Angeles, Pastor, Antoni, Pedreira, Jose, Pristo, Julio, Pena, Jose, Roca, Victor, Rubio, Rafael, Sanchez Rivera, Jose, Sanz, Jesus, Tamargo, Lara, Torres, Rafael, Pehrson, Pehr O., Sandstrom, Eric, Bernasconi, Enos, Gurtner, Vanina, Magenta, Lorenzo, Ampunpong, Uangarun, Bowonwatnuwong, Chureeratana, Chanchai, Patimoaporn, Chetchotisakd, Ploenchan, Chuenyam, Thesinee, Duncombe, Chris, Horsakulthai, Mannassinee, Kantipong, Pacharee, Liddy, John, Phanuphak, Praphan, Pongsurachet, Vithaya, Seekaew, Samroeng, Sonjai, Areerat, Subsri, Nuramon, Suwanagool, Surapol, Techasathit, Wichai, Wankoon, Jaturaporn, Adebiyi, Aderonke, Aldam, Diana, Alexander, Ian, Angus, Brian, Barber, Tristan, Bonnington, Sue, Care, Chris, Carroll, Anne, Cornforth, David, Donaldson, Oscar, Druiff, Laurance, Easterbrook, Philippa, Edwards, Beverley, Ellis, Chris, Fisher, Martin, Fox, Ray, Harrison, Allan, Herman, Sandra, Heald, Lisa, Higgs, Christopher, Jendrulek, Isabelle, Johnson, Margaret, Judges, Lucy, Karim, Fatimah, Kinghorn, George, Laurenti, Julie, Lee, Christine, Leen, Clifford, Legg, Ken, Maw, Raymond, Macconachie, Alisdair, Mckernan, Sinead, Mclean, Lorna, Mcmillan, Andrew, Mguni, Sifiso, Morris, Sheila, Mulchay, Fiona, Mullan, Dee, Mullaney, Scott, Murphy, Maurice, Nunn, Andrew, Ong, Edmund, Owen, Maxine, Palfreeman, Adrian, Perry, Nicky, Peters, Barry, Pozniak, Anton, Ronan, Agnes, Skinner, Cecilia, Stroud, Carol, Takawira, Martin, Tamm, Norbert, Thomas, Rachel, Yee, Thynn Thynn, Vanthuyne, An, Wansborough-Jones, Mark, Weber, Jonathan, White, David, Wilkins, Ed, Wiselka, Martin, Williams, Ian, Waugh, Mike, Wotherspoon, Joyce, Youle, Mike, Doyle, Margaret, Goodwin, Edward, Luskin-Hawk, Roberta, Sullivan, James, Verheggen, Rita, Abrams, Donald, Baxter, John, Besch, C. Lynn, Child, Carroll, Cohn, David, Cooper, Pam, El-Sadr, Wafaa, Farrough, Martha, Fisher, Evelyn, Fuentes, Luis, Gordin, Fred, Graeber, Carol, Kelly, Mary Ellen, Kostman, Jay, Lattanzi, Kelly, Macarthur, Rodger, Makohon, Linda, Markowitz, Norman P., Martinez, Norma, Mastro-Polak, Diane, Mitchell, Vinnie, Mushatt, David, Patterson, Kathryn, Perez, George, Rosmarin, Corey, Rouff, Jack R., Saldanha, Jennifer, Sampson, James, Sawyer, Robert, Standridge, Barbara, Sweeton, Bentley, Tedaldi, Ellen, Thompson, Melanie, Valencia, Patricia, Verlinghieri, Gwen, Walker, Janice, Watson, Vicky, Williams, Bruce, Armstrong, Adam, Banks, Susan, Blazes, David, Barile, Anthony, Coelho, Linda, Dennis, Marilyn, Flaks, Hannah, Gilcrest, Joyce, Gittens, Kathleen, Hopper, Shelia, Humphries, M. J., Spooner, Katherine, Tamminga, Cindy L., Vita, Jean, Wegner, Scott A., Wortmann, Glenn, Bisby, Nicole, Blake, William, Brown, Sheldon, Chilliade, Phillippe, Cole, Teresa, Elliot, Katherine, Geisler, Christiane, Goetz, Matthew, Gomez-Perez, Elizabeth, Helman, Jami, Nahass, Ronald, Leflore, Dirk, Marston, Barbara, Obregon, Maria, Petrolati, Jennifer, Pitrak, David L., Roland, Robert, Rosa, Carol, Rossman, Barbara, Schlueter Wirtz, Susan, Schuck, Suzanne, Scretchings, Tiffany, Simon, Gary, Smith, Mack, Summers, Kimberley, Werhane, Mary Jo, Arduino, Roberto, Bell, Brian, Breaux, Katherine, Cuervo, Hilda, Hale, Carl, Lewis, Stanley, Mall, Mark, Mora, Fransisco, Diez, Martine M., Okhuysen, Pablo, Rodriguez-Barradas, Maria, Schrader, Shannon R., Healy, Lynn, Kaszubski, Chris, Kolber, Michael, Tanner, Tom, Armstrong, Joann, Dahlke, Jennifer, Johnson, Leonard, Kaminski, Patricia, Rhame, Frank, Shoden, Cheryl, Temesgen, Zelalem, Urbanich, Marcy, Valenti, Sharon, Zervos, Marcus, Barrick, Bill, Chaitt, Doreen, Hahn, Barbara, Lane, Cliff, Martell, Dennis, Mcnay, Laura, Metcalf, Julia, Powers, April, Tavel, Jorge A., Loveless, Karen, Peterson, Sue, Sweek, Suzanne, Albrecht, Helmut, Antoine, Nicole, Pell, Paula, Gatell, Jose Maria, Hoy, Jenny, Lifson, Alan, Pederson, Court, Borup, Liselotte, Dragsted, Ulrik Bak, Greve, Anne Fau, Jensen, Karoline, Jens Lundgren, Mollerup, David, Pearson, Mary, Phillips, Andrew, Aboulhab, Jamila, Babiker, Abdel, Cordwell, Brooke, Darbyshire, Janet, Hack, Lisa, Hooker, Malcolm, Moraes, Yolanda, Newberry, Douglas, Nuwagaba-Biribonwoha, Harriet, Hooff, Fionna, Denning, Eileen, Holland Klemme, Leslie, Carey, Cate, Chan, Fonnie, Cooper, David, Courtney-Rodgers, David, Drummond, Fraser, Jacoby, Simone, Law, Matthew, Stewart, Morgan, Pett, Sarah, Alloo, Zarina, Bebchuk, Judy, Bollenbeck, Patty, Duchene, Alain G., Fosdick, Lisa, Harrison, Merrie, Krum, Eric, Larson, Gregg, Meger, Sue, Neaton, James, Nelson, Ray, Quan, Siu-Fun L., Schultz, Terri, Telke, Susan, Thackeray, Lisa, Thompson, Greg, Wentworth, Deborah, Wyman, Nicole, Duncan, William, Ferguson, Elaine, Fox, Lawrence, Gettinger, Nikki, Herrera, Janet, Luzar, Mary Anne, Maeshiro, Mieko, Martinez, Ana, Oseekey, Karen, Baigent, Greg, Capra, William, Duliege, Anne-Marie, Fitzgerald, Linda, Kwakkelstein, Marthin, Maral, Jean, O Hara, Mary, Sahner, David, Weber, Claire, Adam-Perchec, Christine, Barron, Nigel, Bell, Mary Louise, Dolan, Sandra, Eckstrand, Julie, Hicks, Steven, Mcauley, George, Beck, Sharon, Brown, Shawn, and Rupert, Adam

34. Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study.

Author

Molina JM, Andrade-Villanueva J, Echevarria J, Chetchotisakd P, Corral J, David N, Moyle G, Mancini M, Percival L, Yang R, Wirtz V, Lataillade M, Absalon J, and McGrath D

Subjects
Adenine administration & dosage, Adenine adverse effects, Adolescent, Adult, Aged, Aged, 80 and over, Anti-HIV Agents adverse effects, Antiretroviral Therapy, Highly Active methods, Atazanavir Sulfate, Deoxycytidine administration & dosage, Deoxycytidine adverse effects, Emtricitabine, Female, HIV Infections virology, HIV-1 isolation & purification, Humans, Lipids blood, Lopinavir, Male, Middle Aged, Oligopeptides adverse effects, Organophosphonates adverse effects, Pyridines adverse effects, Pyrimidinones adverse effects, RNA, Viral blood, Ritonavir adverse effects, Tenofovir, Treatment Outcome, Viral Load, Young Adult, Adenine analogs & derivatives, Anti-HIV Agents administration & dosage, Deoxycytidine analogs & derivatives, HIV Infections drug therapy, Oligopeptides administration & dosage, Organophosphonates administration & dosage, Pyridines administration & dosage, Pyrimidinones administration & dosage, Ritonavir administration & dosage
Abstract

Background: Once-daily atazanavir/ritonavir demonstrated similar antiviral efficacy to twice-daily lopinavir/ritonavir over 48 weeks, with less gastrointestinal disturbance and a better lipid profile, in treatment-naive patients., Methods: International, multicenter, open-label, 96-week noninferiority randomized trial of atazanavir/ritonavir 300/100 mg once daily vs lopinavir/ritonavir 400/100 mg twice daily, each in combination with fixed-dose tenofovir/emtricitabine 300/200 mg once daily, in antiretroviral-naive, HIV-1-infected patients. The primary end point was the proportion of patients with HIV RNA <50 copies/mL at 48 weeks. Results through 96 weeks are reported., Results: Of 883 patients enrolled, 440 were randomized to atazanavir/ritonavir and 443 to lopinavir/ritonavir. At week 96, more patients receiving atazanavir/ritonavir achieved HIV RNA <50 copies/mL (74% vs 68%, P < 0.05) in the intent-to-treat analysis. On both regimens, 7% of subjects were virologic failures by 96 weeks. Bilirubin-associated disorders were greater in patients taking atazanavir/ritonavir. Treatment-related gastrointestinal adverse events were greater in patients taking lopinavir/ritonavir. Mean changes from baseline in fasting total cholesterol, non-high-density lipoprotein cholesterol, and triglycerides at week 96 were significantly higher with lopinavir/ritonavir (P < 0.0001)., Conclusions: Noninferiority of atazanavir/ritonavir to lopinavir/ritonavir was confirmed at 96 weeks. Atazanavir/ritonavir had a better lipid profile and fewer gastrointestinal adverse events than lopinavir/ritonavir.

Published
2010
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35. [Adherence with national guidelines in hospitalized patients with community-acquired pneumonia. Results of CAPO study in Argentina].

Author

Christensen D, Luna CM, Martínez J, Rodriguez E, Marzoratti L, Gonzalez J, Videla AJ, De Vedia L, Corral J, Benchetrit G, Rodriguez M, Victorio C, Lopardo G, Peyrani P, and Ramirez J

Subjects
Anti-Bacterial Agents administration & dosage, Argentina, Community-Acquired Infections prevention & control, Community-Acquired Infections therapy, Disease Management, Female, Guideline Adherence statistics & numerical data, Humans, Male, Middle Aged, Pneumonia drug therapy, Pneumonia prevention & control, Practice Guidelines as Topic, Quality Control, Retrospective Studies, Guideline Adherence standards, Hospitalization statistics & numerical data, Pneumonia therapy, Quality Indicators, Health Care
Abstract

A committee of six scientific organizations from Argentina developed guidelines for the management of patients with community-acquired pneumonia (CAP).The objective of this study was to evaluate the level of adherence with the recommended care suggested by the guidelines in patients hospitalized with CAP in Argentina. Using quality indicators the management of 436 patients who were hospitalized in 12 Argentinean institutions was evaluated. The care given among the following areas was reviewed: need for hospitalization, need for oxygen therapy, empiric antibiotic therapy, switch therapy, hospital discharge, and prevention. The level of adherence was classified as optimal (>90%), intermediate (60% to 90%), and low (<60%).The selection of the empiric antibiotic therapy and the administration of antibiotics between the first 8 hours after arrival had an adherence greater to 80%. A low level of adherence was found in the areas of switch therapy (53%), prevention of CAP with pneumococcal vaccine (51%) and smoking cessation offered (29%). Using quality indicators it is possible to identify specific areas of management in patients with CAP to a low level of adherence with national guidelines. In Argentina interventions to improve switch therapy and prevention of CAP should be developed.

Published
2007

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