21 results on '"Coronel-Rodríguez, C."'
Search Results
2. Síndrome de Horner pediátrico. A propósito de una serie de 14 casos en un hospital terciario
- Author
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Pérez-Torres-Lobato, M.R., De las Morenas-Iglesias, J., Llempén-López, M., Gómez-Millán-Ruiz, P., Márquez-Vega, C., Espiñeira-Periñán, M.Á., Coronel-Rodríguez, C., Franco-Ruedas, C., Balboa-Huguet, B., and Sánchez-Vicente, J.L.
- Published
- 2021
- Full Text
- View/download PDF
3. Microbioma y mediadores de inflamación intestinal en el síndrome de enterocolitis inducido por proteínas alimentarias
- Author
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Castro Reigía, Ana María, Sabater, Carlos, Navarro, S., Sariego, Lydia, Gutiérrez-Díaz, Isabel, Carbajal Urueña, I., García, Á., Rodríguez, S., Pérez-Solis, David, Molinos-Norniella, Cristina, Jiménez-Treviño, S., Claver Monzón, Ángela, Coronel-Rodríguez, C., Espín Jaime, Beatriz, Domínguez-Ortega, G., Margolles Barros, Abelardo, Delgado, Susana, Díaz Martín, Juan José, Castro Reigía, Ana María, Sabater, Carlos, Navarro, S., Sariego, Lydia, Gutiérrez-Díaz, Isabel, Carbajal Urueña, I., García, Á., Rodríguez, S., Pérez-Solis, David, Molinos-Norniella, Cristina, Jiménez-Treviño, S., Claver Monzón, Ángela, Coronel-Rodríguez, C., Espín Jaime, Beatriz, Domínguez-Ortega, G., Margolles Barros, Abelardo, Delgado, Susana, and Díaz Martín, Juan José
- Published
- 2023
4. Paediatric Horner syndrome. A case series of 14 patients in a tertiary hospital
- Author
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Pérez-Torres-Lobato, M.R., primary, De las Morenas-Iglesias, J., additional, Llempén-López, M., additional, Gómez-Millán-Ruiz, P., additional, Márquez-Vega, C., additional, Espiñeira-Periñán, M.Á., additional, Coronel-Rodríguez, C., additional, Franco-Ruedas, C., additional, Balboa-Huguet, B., additional, and Sánchez-Vicente, J.L., additional
- Published
- 2020
- Full Text
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5. Estudio epidemiológico de parásitos en niños en Sevilla
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Coronel Rodríguez, C., González Soria, M. D., Ruiz Pérez de Pipaón, M., Bergara de la Fuente, M., Aznar Martín, Javier, Ramos Calero, Enrique, and Guisado Rasco, M. C.
- Subjects
education - Published
- 2017
6. Percepción y hábitos de salud de las familias canarias sobre la nutrición de sus hijos
- Author
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Hernández Hernández, Anselmo, Coronel Rodríguez, C., Ferrández Gomáriz, Cleofé, Hernández Cáceres, Sofía, Hernández Rodríguez, Pedro J., Quintana Herrera, Cristina, Hernández Hernández, Anselmo, Coronel Rodríguez, C., Ferrández Gomáriz, Cleofé, Hernández Cáceres, Sofía, Hernández Rodríguez, Pedro J., and Quintana Herrera, Cristina
- Published
- 2017
7. Efficacy and tolerability of SEDIFLÙ in treating dry or productive cough in the pediatric population (SEPEDIA): A pilot, randomized, double-blind, placebo-controlled, multicenter clinical trial.
- Author
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Núñez C, Chiatti MC, Tansella F, Coronel-Rodríguez C, and Risco E
- Subjects
- Humans, Double-Blind Method, Male, Female, Child, Preschool, Child, Pilot Projects, Treatment Outcome, Prospective Studies, Antitussive Agents therapeutic use, Sleep drug effects, Cough drug therapy
- Abstract
The aim of this trial was to assess the effectiveness of Sediflù, a medical device containing active herbal ingredients, on nocturnal and diurnal persistent coughs in children, with a duration of 3 to 7 days. Children with a dry and/or productive cough were enrolled in this prospective, interventional, multicenter, placebo-controlled, double-blind, randomized clinical study. Clinical efficacy was assessed through the evaluation of the soothing action of Sediflù against dry and/or productive coughing, both at night and during the day, and other effects of coughing associated with quality of sleep: frequency, child's quality of sleep, parental quality of sleep and severity. Treatment with Sediflù improved both night-time and day-time cough scores from day 2. The diurnal score also improved significantly in the Sediflù group at days 3 and 7. Sediflù syrup can be considered a valid treatment for cough management in younger children with upper respiratory tract infections, shortening the cough duration., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: CC-R and ER have been scientific advisors for Cinfa and speakers outside the objective of this work. CC-R has worked as principal investigator in clinical studies promotes by Cinfa. CN and MCC are principal investigator in this trial. The other author declares that they have no competing interest.
- Published
- 2024
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8. Transfer of celiac disease-associated immunogenic gluten peptides in breast milk: variability in kinetics of secretion.
- Author
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Ruiz-Carnicer Á, Segura V, Moreno ML, Coronel-Rodríguez C, Sousa C, and Comino I
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- Humans, Female, Adult, Prospective Studies, Longitudinal Studies, Peptides immunology, Peptides urine, Infant, Kinetics, Milk, Human immunology, Milk, Human chemistry, Milk, Human metabolism, Celiac Disease immunology, Celiac Disease metabolism, Glutens immunology, Lactation
- Abstract
Background: Exposure to antigens is crucial for child immune system development, aiding disease prevention and promoting infant health. Some common food antigen proteins are found in human breast milk. However, it is unclear whether gluten antigens linked to celiac disease (CD) are transmitted through breast milk, potentially impacting the development of the infant's immune system., Objective: This study aimed to analyze the passage of gluten immunogenic peptides (GIP) into human breast milk. We evaluated the dynamics of GIP secretion after lactating mothers adopted a controlled gluten-rich diet., Methods: We prospectively enrolled 96 non-CD and 23 CD lactating mothers, assessing total proteins and casein in breast milk, and GIP levels in breast milk and urine. Subsequently, a longitudinal study was conducted in a subgroup of 12 non-CD lactating mothers who adopted a controlled gluten-rich diet. GIP levels in breast milk and urine samples were assayed by multiple sample collections over 96 hours., Results: Analysis of a single sample revealed that 24% of non-CD lactating mothers on a regular unrestricted diet tested positive for GIP in breast milk, and 90% tested positive in urine, with significantly lower concentrations in breast milk. Nevertheless, on a controlled gluten-rich diet and the collection of multiple samples, GIP were detected in 75% and 100% of non-CD participants in breast milk and urine, respectively. The transfer dynamics in breast milk samples were long-enduring and GIP secretion persisted from 0 to 72 h. In contrast, GIP secretion in urine samples was limited to the first 24 h, with inter-individual variations. In the cohort of CD mothers, 82.6% and 87% tested negative for GIP in breast milk and urine, respectively., Conclusions: This study definitively established the presence of GIP in breast milk, with substantial inter-individual variations in secretion dynamics. Our findings provide insights into distinct GIP kinetics observed in sequentially collected breast milk and urine samples, suggesting differential gluten metabolism patterns depending on the organ or system involved. Future research is essential to understand whether GIP functions as sensitizing or tolerogenic agents in the immune system of breastfed infants., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Ruiz-Carnicer, Segura, Moreno, Coronel-Rodríguez, Sousa and Comino.)
- Published
- 2024
- Full Text
- View/download PDF
9. A Single-Center Retrospective Study of Pediatric Vitiligo in a Tertiary Hospital.
- Author
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Martin LB, García Diaz FJ, Bernabeu Wittel J, and Coronel Rodríguez C
- Subjects
- Humans, Retrospective Studies, Male, Child, Female, Child, Preschool, Adolescent, Phototherapy methods, Infant, Calcineurin Inhibitors therapeutic use, Vitiligo therapy, Tertiary Care Centers statistics & numerical data
- Abstract
Vitiligo is a common disorder; however, its management is unknown by many primary-care doctors and pediatricians. Most articles focus on adults; we analyze the characteristics and impact on children. A single-center retrospective study was conducted over 10 years on 254 children diagnosed with vitiligo. About 50.4% were male with a mean age of 8.24 years. There was a slight predominance of nonsegmented vitiligo. About 12.59% had family history of vitiligo and 11.4% of autoimmune diseases. Around 15.7% patients presented other dermatological diseases and 9.05%, autoimmune diseases. No significant statistical differences were found when comparing age, sex, and type of vitiligo with other variables. Almost 96.06% received treatment with calcineurin inhibitors and 66.53% topical steroids. Around 77% obtained repigmentation, and out of the initial nonresponders, 16% responded to phototherapy. In general, our results concur with the scarce literature. A long-term follow-up of children with vitiligo is needed to identify treatment side effects and diseases associated., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Published
- 2024
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10. Differences between parents' and paediatricians' perceptions of mild respiratory infections in childhood: contrast study.
- Author
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Ortiz-Gonzalez L, Delgado-Ojeda J, Guisado-Rasco MC, Santamaria-Orleans A, and Coronel-Rodríguez C
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- Humans, Cross-Sectional Studies, Male, Female, Child, Preschool, Child, Infant, Surveys and Questionnaires, Spain, Adult, Attitude of Health Personnel, Middle Aged, Perception, Respiratory Tract Infections, Parents psychology, Pediatricians psychology, Pediatricians statistics & numerical data
- Abstract
Introduction: Mild respiratory infections are a common reason for consultation in paediatrics, both in the emergency department and in primary care clinics. These conditions, mostly viral and self-limiting, have a significant impact on the healthcare system, school and work absenteeism, and family routines. Despite being common and banal illnesses from a medical perspective, they involve a significant concern in families. The main objective of the contrast study was to compare the perceptions of parents and paediatricians regarding mild respiratory infections in childhood and their impact on family conciliation., Materials and Methods: Two online, cross-sectional surveys were conducted among Spanish paediatricians and parents with children aged 6 months to 12 years, involving 504 paediatricians and 1,447 families, with questions on attitudes towards visits to the paediatric consultation, care burden of minor pathologies, work, and family conciliation, and treatment and prevention of these illnesses., Results: Results showed significant differences in paediatricians' and parents' perceptions in many aspects. According to 34.5% of paediatricians and 27% of parents, families regularly go to the paediatrician without a scheduled visit. Only 4% of parents report having self-medicated their child, while paediatricians raise this percentage significantly to 48%. Regarding the question: "it is normal for a child to have an average of 4 colds a year," only 25.5% of the surveyed families "strongly agree" unlike to 70.2% of paediatricians. 72.8% of paediatricians "strongly agree" with: "in my opinion, it is good for children to get sick to improve their immune system" reduced to 45.9% of parents. Consultations for minor pathologies represent a "high workload" for 60.9% of paediatricians, while this opinion is agreed by only 18.9% of the parents., Conclusion: Mild respiratory infections in childhood are perceived differently by paediatricians and parents. While paediatricians perceive them as a common and manageable phenomenon, parents tend to show higher concern and demand for medical attention. This study underlines the need to improve communication between paediatricians and parents to align perceptions, optimise the use of the health system resources, and improve the efficiency in the management of these common paediatric illnesses., Competing Interests: JD-O and AS-O are Laboratorios Ordesa S.L. employees, but the company had no role in the analysis or interpretation of the data. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Ortiz-Gonzalez, Delgado-Ojeda, Guisado-Rasco, Santamaria-Orleans and Coronel-Rodríguez.)
- Published
- 2024
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11. Molecular epidemiology of pneumococcal carriage in children from Seville, following implementation of the PCV13 immunization program in Andalusia, Spain.
- Author
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de Felipe B, Aboza-García M, González-Galán V, Salamanca de la Cueva I, Martín-Quintero JA, Amil-Pérez B, Coronel-Rodríguez C, Palacios-Soria MÁ, García Ruiz-Santaquiteria MI, Torres-Sánchez MJ, Morón FJ, Cordero-Varela JA, Obando-Pacheco P, and Obando I
- Subjects
- Child, Humans, Cross-Sectional Studies, Molecular Epidemiology, Spain epidemiology, Carrier State epidemiology, Streptococcus pneumoniae genetics, Ampicillin, Immunization Programs, Pneumococcal Infections epidemiology, Pneumococcal Infections prevention & control
- Abstract
Introduction: The 13-valent pneumococcal conjugate vaccine (PCV13) universal vaccination programme was introduced in December 2016 in Andalusia., Methods: A cross-sectional study was conducted on the molecular epidemiology of pneumococcal nasopharyngeal colonization. A total of 397 healthy children were recruited from primary healthcare centres in Seville for the periods 1/4/2018 to 28/2/2020 and 1/11/2021 to 28/2/2022 (PCV13 period). Data from a previous carriage study conducted among healthy and sick children from 1/01/2006 to 30/06/2008 (PCV7 period), were used for comparison of serotype/genotype distributions and antibiotic resistance rates., Results: Overall, 76 (19%) children were colonized with S. pneumoniae during the PCV13 period and there were information available from 154 isolates collected during the PCV7 period. Colonization with PCV13 serotypes declined significantly in the PCV13 period compared with historical controls (11% vs 38%, p = 0.0001), being serotypes 19F (8%), 3 (1%) and 6B (1%) the only circulating vaccine types. Serotypes 15B/C and 11A were the most frequently identified non-PCV13 serotypes during the PCV13 period (14% and 11%, respectively); the later one increased significantly between time periods (p = 0.04). Serotype 11A was exclusively associated in the PCV13 period with ampicillin-resistant variants of the Spain
9V -ST156 clone (ST6521 and genetically related ST14698), not detected in the preceding period., Conclusions: There was a residual circulation of vaccine types following PCV13 introduction, apart from serotype 19F. Serotype 11A increased between PCV13 and PCV7 periods due to emergence and clonal expansion of ampicillin-resistant genotype ST6521., (Copyright © 2022 Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Published by Elsevier España, S.L.U. All rights reserved.)- Published
- 2024
- Full Text
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12. Clinical utility of urinary gluten immunogenic peptides in the follow-up of patients with coeliac disease.
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Garzón-Benavides M, Ruiz-Carnicer Á, Segura V, Fombuena B, García-Fernandez F, Sobrino-Rodriguez S, Gómez-Izquierdo L, Montes-Cano MA, Millan-Domínguez R, Del Carmen Rico M, González-Naranjo C, Bozada-García JM, Coronel-Rodríguez C, Espin B, Díaz J, Comino I, Argüelles-Arias F, Cebolla Á, Romero-Gómez M, Rodriguez-Herrera A, Sousa C, and Pizarro-Moreno Á
- Subjects
- Humans, Follow-Up Studies, Diet, Gluten-Free, Peptides, Patient Compliance, Glutens adverse effects, Glutens analysis, Celiac Disease
- Abstract
Background: Gluten-free diet (GFD) is the only treatment for patients with coeliac disease (CD) and its compliance should be monitored to avoid cumulative damage., Aims: To analyse gluten exposures of coeliac patients on GFD for at least 24 months using different monitoring tools and its impact on duodenal histology at 12-month follow-up and evaluate the interval of determination of urinary gluten immunogenic peptides (u-GIP) for the monitoring of GFD adherence., Methods: Ninety-four patients with CD on a GFD for at least 24 months were prospectively included. Symptoms, serology, CDAT questionnaire, and u-GIP (three samples/visit) were analysed at inclusion, 3, 6, and 12 months. Duodenal biopsy was performed at inclusion and 12 months., Results: At inclusion, 25.8% presented duodenal mucosal damage; at 12 months, this percentage reduced by half. This histological improvement was indicated by a reduction in u-GIP but did not correlate with the remaining tools. The determination of u-GIP detected a higher number of transgressions than serology, regardless of histological evolution type. The presence of >4 u-GIP-positive samples out of 12 collected during 12 months predicted histological lesion with a specificity of 93%. Most patients (94%) with negative u-GIP in ≥2 follow-up visits showed the absence of histological lesions (p < 0.05)., Conclusion: This study suggests that the frequency of recurrent gluten exposures, according to serial determination of u-GIP, could be related to the persistence of villous atrophy and that a more regular follow-up every 6 months, instead of annually, provides more useful data about the adequate adherence to GFD and mucosal healing., (© 2023 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.)
- Published
- 2023
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13. Effects of a Novel Infant Formula on Weight Gain, Body Composition, Safety and Tolerability to Infants: The INNOVA 2020 Study.
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Plaza-Diaz J, Ruiz-Ojeda FJ, Morales J, de la Torre AIC, García-García A, de Prado CN, Coronel-Rodríguez C, Crespo C, Ortega E, Martín-Pérez E, Ferreira F, García-Ron G, Galicia I, Santos-García-Cuéllar MT, Maroto M, Ruiz P, Martín-Molina R, Viver-Gómez S, and Gil A
- Subjects
- Child, Female, Humans, Infant, Body Composition, Breast Feeding, Weight Gain, Bottle Feeding, Infant Formula
- Abstract
Exclusive breastfeeding is recommended for the first six months of life to promote adequate infant growth and development, and to reduce infant morbidity and mortality. However, whenever some mothers are not able to breastfeed their infants, infant formulas mimicking human milk are needed, and the safety and efficacy of each formula should be tested. Here, we report the results of a multicenter, randomized, blinded, controlled clinical trial that aimed to evaluate a novel starting formula on weight gain and body composition of infants up to 6 and 12 months, as well as safety and tolerability. For the intervention period, infants were divided into three groups: group 1 received formula 1 (Nutribén
® Innova 1 (Alter Farmacia S.A., Madrid, Spain) or INN ( n = 70)), with a lower amount of protein, a lower casein to whey protein ratio by increasing the content of α-lactalbumin, and a double amount of docosahexaenoic acid/arachidonic acid than the standard formula; it also contained a thermally inactivated postbiotic ( Bifidobacterium animalis subsp. lactis , BPL1TM HT). Group 2 received the standard formula or formula 2 (Nutriben® Natal (Alter Farmacia S.A., Madrid, Spain) or STD ( n = 70)) and the third group was exclusively breastfed for exploratory analysis and used as a reference (BFD group ( n = 70)). During the study, visits were made at 21 days and 2, 4, 6, and 12 months of age. Weight gain was higher in both formula groups than in the BFD group at 6 and 12 months, whereas no differences were found between STD and INN groups either at 6 or at 12 months. Likewise, body mass index was higher in infants fed the two formulas compared with the BFD group. Regarding body composition, length, head circumference and tricipital/subscapular skinfolds were alike between groups. The INN formula was considered safe as weight gain and body composition were within the normal limits, according to WHO standards. The BFD group exhibited more liquid consistency in the stools compared to both formula groups. All groups showed similar digestive tolerance and infant behavior. However, a higher frequency of gastrointestinal symptoms was reported by the STD formula group ( n = 291), followed by the INN formula ( n = 282), and the BFD groups ( n = 227). There were fewer respiratory, thoracic, and mediastinal disorders among BFD children. Additionally, infants receiving the INN formula experienced significantly fewer general disorders and disturbances than those receiving the STD formula. Indeed, atopic dermatitis, bronchitis, and bronchiolitis were significantly more prevalent among infants who were fed the STD formula compared to those fed the INN formula or breastfed. To evaluate whether there were significant differences between formula treatments, beyond growth parameters, it would seem necessary to examine more precise health biomarkers and to carry out long-term longitudinal studies.- Published
- 2022
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14. New family models. A review of our current situation.
- Author
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Coronel-Rodríguez C, Capilla-Miranda A, and Guisado-Rasco MC
- Published
- 2022
- Full Text
- View/download PDF
15. Negative predictive value of the repeated absence of gluten immunogenic peptides in the urine of treated celiac patients in predicting mucosal healing: new proposals for follow-up in celiac disease.
- Author
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Ruiz-Carnicer Á, Garzón-Benavides M, Fombuena B, Segura V, García-Fernández F, Sobrino-Rodríguez S, Gómez-Izquierdo L, Montes-Cano MA, Rodríguez-Herrera A, Millán R, Rico MC, González-Naranjo C, Bozada-García JM, Díaz J, Coronel-Rodríguez C, Espín B, Romero-Gómez M, Cebolla Á, Sousa C, Comino I, Argüelles F, and Pizarro Á
- Subjects
- Adult, Aged, Celiac Disease diet therapy, Celiac Disease immunology, Celiac Disease pathology, Female, Humans, Intestinal Mucosa metabolism, Male, Middle Aged, Patient Compliance, Predictive Value of Tests, Urinalysis, Young Adult, Celiac Disease urine, Diet, Gluten-Free, Glutens immunology, Intestinal Mucosa pathology
- Abstract
Background: The treatment of celiac disease (CD) is a lifelong gluten-free diet (GFD). The current methods for monitoring GFD conformance, such as a dietary questionnaire or serology tests, may be inaccurate in detecting dietary transgressions, and duodenal biopsies are invasive, expensive, and not a routine monitoring technique., Objectives: Our aim was to determine the clinical usefulness of urine gluten immunogenic peptides (GIP) as a biomarker monitoring GFD adherence in celiac patients and to evaluate the concordance of the results with the degree of mucosal damage., Methods: A prospective observational study was conducted involving 22 de novo CD patients, 77 celiac patients consuming a GFD, and 13 nonceliac subjects. On 3 d of the week, urine samples were collected and the GIP concentrations were tested. Simultaneously, anti-tissue transglutaminase antibodies, questionnaire results, clinical manifestations, and histological findings were analyzed., Results: Approximately 24% (18 of 76) of the celiac patients consuming a GFD exhibited Marsh II-III mucosal damage. Among this population, 94% (17 of 18) had detectable urine GIP; however, between 60% and 80% were asymptomatic and exhibited negative serology and appropriate GFD adherence based on the questionnaire. In contrast, 97% (31 of 32) of the celiac patients without duodenal damage had no detectable GIP. These results demonstrated the high sensitivity (94%) and negative predictive value (97%) of GIP measurements in relation to duodenal biopsy findings. In the de novo CD-diagnosed cohort, 82% (18 of 22) of patients had measurable amounts of GIP in the urine., Conclusions: Determining GIP concentrations in several urine samples may be an especially convenient approach to assess recent gluten exposure in celiac patients and appears to accurately predict the absence of histological lesions. The introduction of GIP testing as an assessment technique for GFD adherence may help in ascertaining dietary compliance and to target the most suitable intervention during follow-up., (Copyright © The Author(s) on behalf of the American Society for Nutrition 2020.)
- Published
- 2020
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16. [Non-IgE-mediated cow's milk allergy: Consensus document of the Spanish Society of Paediatric Gastroenterology, Hepatology, and Nutrition (SEGHNP), the Spanish Association of Paediatric Primary Care (AEPAP), the Spanish Society of Extra-hospital Paediatrics and Primary Health Care (SEPEAP), and the Spanish Society of Paediatric ClinicaL Immunology, Allergy, and Asthma (SEICAP)].
- Author
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Espín Jaime B, Díaz Martín JJ, Blesa Baviera LC, Claver Monzón Á, Hernández Hernández A, García Burriel JI, Mérida MJG, Pinto Fernández C, Coronel Rodríguez C, Román Riechmann E, and Ribes Koninckx C
- Subjects
- Child, Humans, Milk Hypersensitivity diagnosis, Milk Hypersensitivity prevention & control, Spain, Milk Hypersensitivity therapy, Milk Proteins immunology, Pediatrics
- Abstract
Non-IgE-mediated cow's milk allergy is a frequent disorder in paediatrics. As patients might be seen by professionals from different specialties and levels of expertise, a great variability in diagnostic procedures and disease monitoring is commonly observed. Therefore, four scientific societies involved in its management have developed a consensus document providing specific recommendations related to its prevention, diagnosis, treatment and follow up., (Copyright © 2019 Asociación Española de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.)
- Published
- 2019
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17. Influence of infant feeding on the excretion of gluten immunopeptides in feces.
- Author
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Coronel Rodríguez C, Quero Acosta L, Argüelles Martín F, and Cinta Guisado-Rasco M
- Subjects
- Breast Feeding, Case-Control Studies, Female, Glutens administration & dosage, Glutens immunology, Humans, Infant, Infant Formula, Male, Milk, Human immunology, Prospective Studies, Single-Blind Method, Spain, Feces chemistry, Gliadin analysis, Glutens analysis, Milk, Human chemistry
- Abstract
Introduction: the secretion of antigens from the diet into breast milk has been extensively documented. The transfer of gliadin could be critical for the development of an immune response., Objectives: to investigate the presence of immunogenic gluten peptides in the feces of infants fed with different diets., Material and Methods: a blind, prospective, controlled, collaborative study was performed in three hospitals, between September 2016 and January 2017. The study protocol was approved by the Ethics Committee of the hospitals in Seville prior to starting the study., Results: the cohort was divided into three groups of 30 infants: an experimental group (average age 9.2 ± 2.8 weeks) with exclusive breastfeeding, a control group 1 (average age 10.3 ± 3.3 weeks) exclusively fed with onset formula and a control group 2 (average age 56 ± 3.7 weeks) with infants that consumed gluten on a regular basis. The peptide 33-mer of gliadin was negative in all feces samples from both the experimental and control group 1. With regard to control group 2, the peptide 33-mer of gliadin was negative in 23% of cases (seven children). There was no difference in the amount of gluten ingested by these children compared to those who excreted the 33-mer peptide., Conclusions: the failure to detect gluten in the feces of infants that were exclusively breastfed indicates that it is probably below the limits of detection. Healthy children who consume gluten may not excrete it in feces.
- Published
- 2019
- Full Text
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18. [Mothers single by choice. A growing, but not recent reality].
- Author
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Coronel Rodríguez C, Chávez Barco AM, González Soria MD, and Guisado Rasco MC
- Subjects
- Adult, Female, Humans, Retrospective Studies, Spain, Choice Behavior, Mothers, Single Parent statistics & numerical data
- Published
- 2017
- Full Text
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19. [The clinical manifestations of peptic esophagitis in children].
- Author
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Espín Jaime B, Coronel Rodríguez C, Allieri M, Ramírez Gurruchaga F, and Argüelles Martín F
- Subjects
- Adolescent, Aging pathology, Biopsy, Chi-Square Distribution, Child, Child, Preschool, Endoscopy, Digestive System, Esophagus pathology, Humans, Infant, Mucous Membrane pathology, Esophagitis, Peptic diagnosis
- Abstract
Objective: To study the clinical spectrum of peptic esophagitis during childhood., Patients and Methods: The clinical histories of 445 cases of peptic esophagitis, diagnosed by means of endoscopy or biopsy, in children between 1 month and 14 years of age were reviewed in order to analyze the reasons for endoscopy and the clinical symptoms presented., Results: In the group under 2 years of age, the main symptom was vomiting, while in those between 2 and 6 years old it was also vomiting followed by abdominal pain. However, there was no significant difference between the groups. In the group over 6 years old, the chief complaint was abdominal pain with a statistically significant difference., Conclusions: 1) We found a statistically significant relationship between age and clinical data. 2) After comparing the grades of esophagitis with clinical symptoms and the age of the patient, no statistical correlation was found. 3) There is a high frequency of esophagitis I because of an early diagnosis.
- Published
- 1996
20. [Diagnosis of gastroesophageal reflux: ultrasonographic method].
- Author
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Lucio-Villegas Menéndez M, Argüelles Martín F, Coronel Rodríguez C, González Fernández F, and González Prada F
- Subjects
- Child, Child, Preschool, Female, Humans, Infant, Male, Ultrasonography, Gastroesophageal Reflux diagnostic imaging
- Abstract
In this study, 63 infants, 38 males and 25 females, with pathology that suggested gastro-esophageal reflux, were studied. These patients were between one month and 7-1/2 years of age, with a mean age of 29 months and a standard deviation of 28.1 months. All patients underwent a barium study of the esophagus and the stomach, evaluated according to the criteria of Cleveland, an esophageal scintigram to detect GER, performed according to the criteria of Fernández and Argüelles, and an abdominal echography according to the technique of Naik and Moore. The test was considered a true positive if the echography was positive along with one other positive examination. A false positive was considered if only the echography were positive. A true negative was when the echography was negative along with another negative test. A false negative was when the echography was negative and some other test was positive. The following results were obtained for the echography: a sensitivity of 68%, a specificity of 84.61% and a safety factor of 71.2%. We conclude that echography can be considered as a complimentary examination for the study of GER, given it harmless nature, the availability of the equipment and the possibility of prolonging the exploration which can be recorded on videotape.
- Published
- 1993
21. [Total tracheal agenesis].
- Author
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Coronel Rodríguez C, Campos Alonso E, Torres Olivera FJ, Pérez Losada J, Saenz Reguera C, and Durán de Vargas L
- Subjects
- Female, Humans, Infant, Newborn, Radiography, Trachea diagnostic imaging, Trachea pathology, Trachea abnormalities
- Published
- 1992
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