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216 results on '"Cornea -- Research"'

7. Accelerated corneal graft rejection in baby rats

Author

Schwartzkopff, Johannes, Berger, Moritz, Birnbaum, Florian, Bohringer, Daniel, and Reinhard, Thomas

Subjects
Graft rejection -- Development and progression, Graft rejection -- Models, Graft rejection -- Research, Cornea -- Transplantation, Cornea -- Complications and side effects, Cornea -- Models, Cornea -- Research, Health
Published
2010

8. The variation in transparency of amniotic membrane used in ocular surface regeneration

Author

Connon, C.J., Doutch, J., Chen, B., Hopkinson, A., Mehta, J.S., Nakamura, T., Kinoshita, S., and Meek, K.M.

Subjects
Amnion -- Usage, Amnion -- Physiological aspects, Amnion -- Research, Amniotic sac -- Usage, Amniotic sac -- Physiological aspects, Amniotic sac -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Research, Health
Published
2010

9. Assessment of corneal biomechanical properties and intraocular pressure with the Ocular Response Analyzer in childhood myopia

Author

Chang, Pei-Yao, Chang, Shu-Wen, and Wang, Jiun-Yi

Subjects
Myopia -- Diagnosis, Myopia -- Development and progression, Myopia -- Demographic aspects, Myopia -- Research, Cornea -- Physiological aspects, Cornea -- Research, Intraocular pressure -- Physiological aspects, Intraocular pressure -- Research, Anterior chamber (Eye) -- Research, Anterior chamber (Eye) -- Physiological aspects, Health
Published
2010

10. Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S)

Author

Studeny, Pavel, Farkas, Andrej, Vokrojova, Magdalena, Liskova, Petra, and Jirsova, Katerina

Subjects
Membrane, Basement -- Physiological aspects, Membrane, Basement -- Research, Cornea -- Transplantation, Cornea -- Methods, Cornea -- Patient outcomes, Cornea -- Research, Health
Published
2010

12. Observation of the in vivo movement of host keratocytes into donor tissue following corneal graft; a novel technique

Author

Macdonald, E.C.A., Gregory, M.E., Lockington, D., Kennedy, A., Roberts, F., and Ramaesh, K.

Subjects
Connective tissue cells -- Physiological aspects, Connective tissue cells -- Research, In situ hybridization -- Usage, In situ hybridization -- Research, Cells -- Motility, Cells -- Analysis, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Research, Health
Published
2010

13. Management and outcomes after multiple corneal and solid organ transplantations from a donor infected with rabies virus

Author

Maier, T., Schwarting, A., Mauer, D., Ross, R.S., Martens, A., Kliem, V., Wahl, J., Panning, M., Baumgarte, S., Muller, T., Pfefferle, S., Ebel, H., Schmidt, J., Tenner-Racz, K., Racz, P., Schmid, M., Struber, M., Wolters, B., Gotthardt, D., Bitz, F., Frisch, L., Pfeiffer, N., Fickenscher, H., Sauer, P., Rupprecht, C.E., Roggendorf, M., Haverich, A., Galle, P., Hoyer, J., and Drosten, C.

Subjects
Rabies -- Care and treatment, Rabies -- Patient outcomes, Rabies -- Demographic aspects, Rabies -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Research, Liver -- Transplantation, Liver -- Patient outcomes, Liver -- Research, Health, Health care industry
Published
2010

16. Back-up procedure for graft failure in Descemet membrane endothelial keratoplasty (DMEK)

Author

Dapena, Isabel, Ham, Lisanne, van Luijk, Chantal, van der Wees, Jacqueline, and Melles, Gerrit R.J.

Subjects
Graft rejection -- Care and treatment, Graft rejection -- Research, Outcome and process assessment (Health Care) -- Research, Glaucoma -- Care and treatment, Glaucoma -- Patient outcomes, Glaucoma -- Research, Cornea -- Transplantation, Cornea -- Methods, Cornea -- Patient outcomes, Cornea -- Research, Health
Published
2010

17. Evaluation of the impact of intracorneal ring segments implantation on the quality of life of patients with keratoconus using the NEI-RQL (National Eye Institute Refractive Error Quality of life) instrument

Author

de Freitas Santos Paranhos, J., Avila, M.P., Paranhos, A., Jr., and Schor, P.

Subjects
Keratoconus -- Care and treatment, Keratoconus -- Patient outcomes, Keratoconus -- Research, Quality of life -- Health aspects, Quality of life -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Research, Health
Published
2010

18. Robotic microsurgery: corneal transplantation

Author

Bourges, J.-L., Hubschman, J.-P., Burt, B., Culjat, M., and Schwartz, S.D.

Subjects
Microsurgery -- Methods, Microsurgery -- Patient outcomes, Microsurgery -- Research, Cornea -- Transplantation, Cornea -- Technology application, Cornea -- Research, Technology application, Health
Published
2009

19. Use of paediatric donor tissue in Descemet stripping endothelial keratoplasty

Author

Huang, T., Wang, Y., Hu, A., Luo, Y., and Chen, J.

Subjects
Donation of organs, tissues, etc. -- Demographic aspects, Donation of organs, tissues, etc. -- Research, Cornea -- Transplantation, Cornea -- Complications and side effects, Cornea -- Research, Children -- Surgery, Children -- Complications and side effects, Children -- Research, Health
Published
2009

24. A steroid-inducible promoter for the cornea

Author

Parker, D.G.A., Brereton, H.M., Klebe, S., Coster, D.J., and Williams, K.A.

Subjects
Corticosteroids -- Dosage and administration, Corticosteroids -- Research, Promoters (Genetics) -- Research, Cornea -- Transplantation, Cornea -- Research, Health
Published
2009

25. Surveillance of severe chemical corneal injuries in the UK

Author

Macdonald, E.C.A., Cauchi, P.A., Azuara-Blanco, A., and Foot, B.

Subjects
Sentinel health events -- Reports, Cornea -- Injuries, Cornea -- Distribution, Cornea -- Research, Company distribution practices, Health
Published
2009

26. Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation

Author

Ellenberg, D., Shi, J., Jain, S., Chang, J.-H., Ripps, H., Brady, S., Melhem, E.R., Lakkis, F., Adamis, A., Chen, D.-F., Ellis-Behnke, R., Langer, R.S., Strittmatter, S.M., and Azar, D.T.

Subjects
Neurotrophic functions -- Physiological aspects, Neurotrophic functions -- Research, Optic nerve -- Physiological aspects, Optic nerve -- Research, Eye -- Enucleation, Eye -- Patient outcomes, Eye -- Complications and side effects, Eye -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Complications and side effects, Cornea -- Research, Retina -- Blood-vessels, Retina -- Physiological aspects, Retina -- Research, Health
Published
2009

27. Sterility control and long-term eye-bank storage of cultured human limbal epithelial cells for transplantation

Author

Utheim, T.P., Raeder, S., Utheim, O.A., de la Paz, M., Roald, B., and Lyberg, T.

Subjects
Eye banks -- Research, Eye banks -- Standards, Epithelial cells -- Storage, Cornea -- Transplantation, Cornea -- Standards, Cornea -- Research, Medical equipment -- Sterilization, Medical equipment -- Standards, Medical equipment -- Research, Tissues -- Protection and preservation, Tissues -- Standards, Health
Published
2009

30. Longitudinal analysis of corneal topography in suspected keratoconus

Author

Shirayama-Suzuki, M., Amano, S., Honda, N., Usui, T., Yamagami, S., and Oshika, T.

Subjects
Keratoconus -- Development and progression, Keratoconus -- Research, Cornea -- Physiological aspects, Cornea -- Measurement, Cornea -- Research, Health
Published
2009

34. Analysis of soluble vascular endothelial growth factor receptor-1 secreted from cultred corneal and oral mucosal epithelial cell sheets in vitro

Author

Kanayama, S., Nishida, K., Yamato, M., Hayashi, R., Maeda, N., Okano, T., and Tano, Y.

Subjects
Vascular endothelial growth factor -- Dosage and administration, Vascular endothelial growth factor -- Research, Endothelium -- Physiological aspects, Endothelium -- Research, Neovascularization -- Development and progression, Neovascularization -- Research, Cornea -- Transplantation, Cornea -- Complications and side effects, Cornea -- Physiological aspects, Cornea -- Research, Health
Published
2009

35. Corticosteroids for bacterial corneal ulcers

Author

Srinivasan, M., Lalitha, P., Mahalakshmi, R., Prajna, N.V., Mascarenhas, J., Chidambaram, J.D., Lee, S., Hong, K.C., Zegans, M., Glidden, D.V., McLeod, S., Whitcher, J.P., Lietman, T.M., and Acharya, N.R.

Subjects
Corticosteroids -- Dosage and administration, Corticosteroids -- Research, Cornea -- Ulcers, Cornea -- Care and treatment, Cornea -- Research, Health
Published
2009

36. Recurrent ectasia in corneal grafts and outcomes of repeat keratoplasty for keratoconus

Author

Patel, S.V., Malta, J.B., Banitt, M.R., Mian, S.i., Sugar, A., Elner, V.M., Tester, R.A., Farjo, Q.A., and Soong, H.K.

Subjects
Keratoconus -- Care and treatment, Keratoconus -- Patient outcomes, Keratoconus -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Research, Cornea -- Complications and side effects, Health
Published
2009

37. Posterior lamellar keratoplasty - comparison of deep lamellar endothelial keratoplasty and Descemet stripping automated endothelial keratoplasty in the same patients: a patient's perspective

Author

Bahar, I., Sansanayudh, W., Levinger, E., Kaiserman, I., Srinivasan, S., and Rootman, D.

Subjects
Outcome and process assessment (Health Care) -- Research, Endothelium -- Physiological aspects, Endothelium -- Research, Quality of life -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Research, Health
Published
2009

39. The elasticity and rigidity of the outer coats of the eye

Author

Asejczyk-Widlicka, M. and Pierscionek, B.K.

Subjects
Cornea -- Physiological aspects, Cornea -- Research, Sclera -- Physiological aspects, Sclera -- Research, Intraocular pressure -- Physiological aspects, Intraocular pressure -- Research, Health
Published
2008

41. Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride

Author

Liang, H., Baudouin, C., Pauly, A., and Brignole-Baudouin, F.

Subjects
Chlorides -- Dosage and administration, Chlorides -- Research, Dichloropropane -- Dosage and administration, Dichloropropane -- Research, Conjunctiva -- Physiological aspects, Conjunctiva -- Research, Cornea -- Physiological aspects, Cornea -- Research, Health
Published
2008

46. Upregulation of chemokine expression in murine cornea due to mechanical trauma or endotoxin

Author

Pillai, R.G., Beutelspacher, S.C., Larkin, D.F.P., and George, A.J.T.

Subjects
Chemokines -- Measurement, Chemokines -- Research, Cornea -- Physiological aspects, Cornea -- Research, Messenger RNA -- Analysis, Endotoxins -- Physiological aspects, Graft rejection -- Prevention, Cornea -- Transplantation, Cornea -- Patient outcomes, Health
Published
2008

47. Long-term recovery of the human corneal epithelium after toxic injury by benzalkonium chloride

Author

Hughes, E.H., Pretorius, M., Eleftheriadis, H., and Liu, C.S.C.

Subjects
Chlorides -- Complications and side effects, Chlorides -- Physiological aspects, Dichloropropane -- Complications and side effects, Dichloropropane -- Physiological aspects, Cornea -- Injuries, Cornea -- Patient outcomes, Cornea -- Research, Drugs -- Health aspects, Drugs -- Patient outcomes, Drugs -- Research, Health
Published
2007

49. Novel pressure-to-cornea index in glaucoma

Author

Iliev, Milko E., Meyenberg, Alexander, Buerki, Ernst, Shafranov, George, and Shields, M. Bruce

Subjects
Glaucoma -- Risk factors, Glaucoma -- Research, Intraocular pressure -- Physiological aspects, Intraocular pressure -- Research, Cornea -- Physiological aspects, Cornea -- Research, Health
Published
2007

50. Effect of overexpression of ppar[gamma] on the healing process of corneal alkali burn in mice

Author

Saika, Shizuya, Yamanaka, Osamu, Okada, Yuka, Miyamoto, Takeshi, Kitano, Ai, Flanders, Kathleen C., Ohnishi, Yoshitaka, Nakajima, Yuji, Kao, Winston W.-Y., and Ikeda, Kazuo

Subjects
Cellular control mechanisms -- Research, Wound healing -- Research, Regeneration (Biology) -- Research, Cornea -- Research, Cornea -- Physiological aspects, Cornea -- Injuries, Cell research, Biological sciences
Abstract

Wound healing involves both local cells and inflammatory cells. Alkali burn of ocular surface tissue is a serious clinical problem often leading to permanent visual impairment resulting from ulceration, scarring and neovascularization during healing. Behaviors of corneal cells and inflammatory cells are orchestrated by growth factor signaling networks that have not been fully uncovered. Here we showed that adenoviral gene introduction of peroxisome proliferator-activated receptor-[gamma]/(PPAR[gamma]) inhibits activation of ocular fibroblasts and macrophages in vitro and also induced anti-inflammatory and anti-fibrogenic responses in an alkali-burned mouse cornea. PPAR[gamma] overexpression suppressed upregulation of inflammation/scarring-related growth factors and matrix metalloproteinases (MMPs) in macrophages. It also suppressed expression of such growth factors and collagen I[alpha]2 and myofibroblast generation upon exposure to TGF[beta]1. Exogenous PPAR[gamma] did not alter phosphorylation of Smad2, but inhibited its nuclear translocation. PPAR[gamma] overexpression enhanced proliferation of corneal epithelial cells, but not of fibroblasts in vitro. Epithelial cell expression of MMP-2/-9 and TGF[beta]1 and its migration were suppressed by PPAR[gamma] overexpression. In vivo experiments showed that PPAR[gamma] gene introduction suppressed monocytes/macrophages invasion and suppressed the generation of myofibroblasts, as well as upregulation of cytokines/growth factors and MMPs in a healing cornea. In vivo re-epitheliazation with basement membrane reconstruction in the healing, burned, cornea was accelerated by PPAR[gamma]-Ad expression, although PPAR[gamma] overexpression was considered to be unfavorable for cell migration. Together, these data suggest that overexpression of PPAR[gamma] may represent an effective new strategy for treatment of ocular surface burns. peroxisome proliferator-activated receptor-[gamma]; gene therapy; macrophage; fibroblast; Smad doi:10.1152/ajpcell.00332.2006

Published
2007

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