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188 results on '"Cornblath, Wayne T."'

2. Orbital Signs of Parasellar Syndromes

Author

Choe, Christina H., Cornblath, Wayne T., Servat, J. Javier, editor, Black, Evan H., editor, Nesi, Frank A., editor, Gladstone, Geoffrey J., editor, and Calvano, Christopher J., editor

Published
2021
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9. Orbital Signs of Parasellar Syndromes

Author

Choe, Christina H., Cornblath, Wayne T., Black, Evan H., editor, Nesi, Frank A., editor, Calvano, Christopher J., editor, Gladstone, Geoffrey J., editor, and Levine, Mark R., editor

Published
2012
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15. Association of Individual-Level Factors With Visual Outcomes in Optic Neuritis

Author

De Lott, Lindsey B., Burke, James F., Andrews, Chris A., Costello, Fiona, Cornblath, Wayne T., Trobe, Jonathan D., Lee, Paul P., and Kerber, Kevin A.

Subjects
Adult, Male, Optic Neuritis, genetic structures, Adolescent, Research, Visual Acuity, Middle Aged, eye diseases, Online Only, Young Adult, Treatment Outcome, Neurology, Adrenal Cortex Hormones, Humans, Administration, Intravenous, Female, Original Investigation
Abstract

This secondary analysis of a randomized clinical trial develops models of individual-level visual outcomes for patients with optic neuritis., Key Points Question What individual-level factors are associated with visual acuity in patients with optic neuritis? Findings In this secondary analysis of clinical trial data of 455 patients with optic neuritis, baseline visual acuity was associated with 1-year visual acuity, and baseline visual acuity and treatment status were associated with visual acuity at 15 days. However, for the median baseline visual acuity of 20/66, the difference of medians in visual acuity at 15 days was small with intravenous corticosteroids (20/18) compared with placebo (20/23). Meaning In this study, the primary factor associated with long-term visual acuity was severity of baseline vision impairment, and the temporary early benefit of intravenous corticosteroids was of questionable clinical importance., Importance Using corticosteroids to treat acute demyelinating optic neuritis has been identified as an area for shared decision-making. However, no analysis exists to support personalized shared decision-making that considers long- and short-term treatment benefits. Objective To develop models of individual-level visual outcomes for patients with optic neuritis. Design, Setting, and Participants This secondary analysis of the Optic Neuritis Treatment Trial (ONTT), a randomized clinical trial, was performed at 14 academic eye centers and 1 large community eye center. Adults aged 18 to 46 years with incident acute unilateral optic neuritis within 8 days of vision loss onset were included. Data were collected from July 1988 to June 1991, downloaded on October 15, 2018, and analyzed from January 24, 2019, to February 20, 2020, using multivariable linear regression modeling. Exposures Intravenous corticosteroids vs placebo. Main Outcomes and Measures Visual acuity (VA) at 1 year. Secondary outcomes were 1-year contrast sensitivity (CS) and VA and CS at 15 and 30 days. Independent variables included age, sex, race, multiple sclerosis status, optic neuritis episodes in the fellow eye, vision symptoms (days), pain, optic disc swelling, viral illness, treatment group, and baseline VA or CS. Results Of the 455 participants, median age was 31.8 (interquartile range [IQR], 26.3-37.0) years; 350 (76.9%) were women; and 388 (85.3%) were white. For 410 participants (90.1%) with 1-year outcomes, median VA improved from 20/66 (IQR, 20/28-20/630) at enrollment to 20/17 (IQR, 20/14-20/21) at 1 year. Baseline VA was the primary variable associated with 1-year VA (regression coefficient, 0.056 [95% CI, 0.008-0.103]; P = .02) if baseline VA was better than count fingers (CF). At 15 days, baseline VA and treatment status were associated with VA in those participants with baseline VA better than CF (regression coefficient, 0.305 [95% CI, 0.231-0.380]; F = 9.42; P

Published
2020

16. Posterior Cortical Atrophy: Characteristics From a Clinical Data Registry.

Author

Olds, Jennifer J, Hills, William L, Warner, Judith, Falardeau, Julie, Alasantro, Lori Haase, Moster, Mark L, Egan, Robert A, Cornblath, Wayne T, Lee, Andrew G, Frishberg, Benjamin M, Turbin, Roger E, Katz, David M, Charley, John A, Pelak, Victoria S, Olds, Jennifer J, Hills, William L, Warner, Judith, Falardeau, Julie, Alasantro, Lori Haase, Moster, Mark L, Egan, Robert A, Cornblath, Wayne T, Lee, Andrew G, Frishberg, Benjamin M, Turbin, Roger E, Katz, David M, Charley, John A, and Pelak, Victoria S

Published
2020

22. Posterior Cortical Atrophy: Characteristics From a Clinical Data Registry

Author

Olds, Jennifer J., primary, Hills, William L., additional, Warner, Judith, additional, Falardeau, Julie, additional, Alasantro, Lori Haase, additional, Moster, Mark L., additional, Egan, Robert A., additional, Cornblath, Wayne T., additional, Lee, Andrew G., additional, Frishberg, Benjamin M., additional, Turbin, Roger E., additional, Katz, David M., additional, Charley, John A., additional, and Pelak, Victoria S., additional

Published
2020
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24. Glomus Cell Tumor of the Orbit

Author

Pribila, Jonathan T., Cornblath, Wayne T., Ramocki, John M., Marentette, Lawrence J., Flint, Andrew, and Elner, Victor M.

Published
2010

29. Minocycline treatment and pseudotumor cerebri syndrome

Author

Chiu, Ann M., Chuenkongkaew, Wanicha L., Cornblath, Wayne T., Trobe, Jonathan D., Digre, Kathleen B., Dotan, Shlomo A., Musson, Kenneth H., and Eggenberger, Eric R.

Subjects
Minocycline -- Adverse and side effects, Intracranial hypertension -- Causes of, Health
Published
1998

42. Author reply

Author

Miller, Neil R., primary, Parikh, Mona, additional, Lee, Andrew G., additional, Kardon, Randy H., additional, Savino, Peter J., additional, Cornblath, Wayne T., additional, Eggenberger, Eric, additional, and Golnik, Karl C., additional

Published
2007
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