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3. Two- and Three-Dimensional Culture Systems: Respiratory In Vitro Tissue Models for Chemical Screening and Risk-Based Decision Making.

Author

Wallace, Joanne, McElroy, Mary C., Klausner, Mitchell, Corley, Richard, and Ayehunie, Seyoum

Subjects
CHEMICAL safety, RESPIRATORY organs, ANIMAL experimentation, CHEMICAL models, RISK assessment, LUNGS
Abstract

Risk of lung damage from inhaled chemicals or substances has long been assessed using animal models. However, New Approach Methodologies (NAMs) that replace, reduce, and/or refine the use of animals in safety testing such as 2D and 3D cultures are increasingly being used to understand human-relevant toxicity responses and for the assessment of hazard identification. Here we review 2D and 3D lung models in terms of their application for inhalation toxicity assessment. We highlight a key case study for the Organization for Economic Cooperation and Development (OECD), in which a 3D model was used to assess human toxicity and replace the requirement for a 90-day inhalation toxicity study in rats. Finally, we consider the regulatory guidelines for the application of NAMs and potential use of different lung models for aerosol toxicity studies depending on the regulatory requirement/context of use. [ABSTRACT FROM AUTHOR]

Published
2025
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5. Extracellular matrix in lung development, homeostasis and disease.

Author

Zhou, Yong, Horowitz, Jeffrey C, Naba, Alexandra, Ambalavanan, Namasivayam, Atabai, Kamran, Balestrini, Jenna, Bitterman, Peter B, Corley, Richard A, Ding, Bi-Sen, Engler, Adam J, Hansen, Kirk C, Hagood, James S, Kheradmand, Farrah, Lin, Qing S, Neptune, Enid, Niklason, Laura, Ortiz, Luis A, Parks, William C, Tschumperlin, Daniel J, White, Eric S, Chapman, Harold A, and Thannickal, Victor J

Subjects
Lung, Extracellular Matrix, Humans, Lung Diseases, Extracellular Matrix Proteins, Homeostasis, Phenotype, Biomechanical Phenomena, Stem Cell Research, Lung Cancer, Regenerative Medicine, Cancer, Stem Cell Research - Nonembryonic - Non-Human, 1.1 Normal biological development and functioning, Underpinning research, Respiratory, Biological Sciences, Biochemistry & Molecular Biology
Abstract

The lung's unique extracellular matrix (ECM), while providing structural support for cells, is critical in the regulation of developmental organogenesis, homeostasis and injury-repair responses. The ECM, via biochemical or biomechanical cues, regulates diverse cell functions, fate and phenotype. The composition and function of lung ECM become markedly deranged in pathological tissue remodeling. ECM-based therapeutics and bioengineering approaches represent promising novel strategies for regeneration/repair of the lung and treatment of chronic lung diseases. In this review, we assess the current state of lung ECM biology, including fundamental advances in ECM composition, dynamics, topography, and biomechanics; the role of the ECM in normal and aberrant lung development, adult lung diseases and autoimmunity; and ECM in the regulation of the stem cell niche. We identify opportunities to advance the field of lung ECM biology and provide a set recommendations for research priorities to advance knowledge that would inform novel approaches to the pathogenesis, diagnosis, and treatment of chronic lung diseases.

Published
2018

6. In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products: Workshop Proceedings, Conclusions and Paths Forward for In Vitro Model Use

Author

Behrsing, Holger, Hill, Erin, Raabe, Hans, Tice, Raymond, Fitzpatrick, Suzanne, Devlin, Robert, Pinkerton, Kent, Oberdörster, Günter, Wright, Chris, Wieczorek, Roman, Aufderheide, Michaela, Steiner, Sandro, Krebs, Tobias, Asgharian, Bahman, Corley, Richard, Oldham, Michael, Adamson, Jason, Li, Xiang, Rahman, Irfan, Grego, Sonia, Chu, Pei-Hsuan, McCullough, Shaun, and Curren, Rodger

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Lung, Prevention, Tobacco, Tobacco Smoke and Health, 2.2 Factors relating to the physical environment, Aetiology, Cancer, Respiratory, Good Health and Well Being, Aerosols, Animals, Electronic Nicotine Delivery Systems, Humans, In Vitro Techniques, Smoking, Species Specificity, Tobacco Products, Toxicity Tests, United States, United States Food and Drug Administration, computational fluid dynamics, COPD, dosimetry, e-cigarette exposure systems, ex vivo lung models, in vitro, in vitro lung, in vitro models, non-animal alternatives, pulmonary models, reconstructed epithelium airway models, tobacco exposure systems, tobacco regulatory science, Toxicology, Veterinary sciences
Abstract

In 2009, the passing of the Family Smoking Prevention and Tobacco Control Act facilitated the establishment of the FDA Center for Tobacco Products (CTP), and gave it regulatory authority over the marketing, manufacture and distribution of tobacco products, including those termed 'modified risk'. On 4-6 April 2016, the Institute for In Vitro Sciences, Inc. (IIVS) convened a workshop conference entitled, In Vitro Exposure Systems and Dosimetry Assessment Tools for Inhaled Tobacco Products, to bring together stakeholders representing regulatory agencies, academia and industry to address the research priorities articulated by the FDA CTP. Specific topics were covered to assess the status of current in vitro smoke and aerosol/vapour exposure systems, as well as the various approaches and challenges to quantifying the complex exposures in in vitro pulmonary models developed for evaluating adverse pulmonary events resulting from tobacco product exposures. The four core topics covered were: a) Tobacco Smoke and E-Cigarette Aerosols; b) Air-Liquid Interface-In Vitro Exposure Systems; c) Dosimetry Approaches for Particles and Vapours/In Vitro Dosimetry Determinations; and d) Exposure Microenvironment/Physiology of Cells. The 2.5-day workshop included presentations from 20 expert speakers, poster sessions, networking discussions, and breakout sessions which identified key findings and provided recommendations to advance these technologies. Here, we will report on the proceedings, recommendations, and outcome of the April 2016 technical workshop, including paths forward for developing and validating non-animal test methods for tobacco product smoke and next generation tobacco product aerosol/vapour exposures. With the recent FDA publication of the final deeming rule for the governance of tobacco products, there is an unprecedented necessity to evaluate a very large number of tobacco-based products and ingredients. The questionable relevance, high cost, and ethical considerations for the use of in vivo testing methods highlight the necessity of robust in vitro approaches to elucidate tobacco-based exposures and how they may lead to pulmonary diseases that contribute to lung exposure-induced mortality worldwide.

Published
2017

10. FLAMINGOS-2: The Facility Near-Infrared Wide-field Imager & Multi-Object Spectrograph for Gemini

Author

Eikenberry, Stephen, Elston, Richard, Raines, S. Nicholas, Julian, Jeff, Hanna, Kevin, Hon, David, Julian, Roger, Bandyopadhyay, R., Bennett, J. Greg, Bessoff, Aaron, Branch, Matt, Corley, Richard, Eriksen, John-David, Frommeyer, Skip, Gonzalez, Anthony, Herlevich, Michael, Marin-Franch, Antonio, Marti, Jose, Murphey, Charlie, Rashkin, David, Warner, Craig, Leckie, Brian, Gardhouse, W. Rusty, Fletcher, Murray, Dunn, Jennifer, Wooff, Robert, and Hardy, Tim

Subjects
Astrophysics
Abstract

We report on the design and status of the FLAMINGOS-2 instrument - a fully-cryogenic facility near-infrared imager and multi-object spectrograph for the Gemini 8-meter telescopes. FLAMINGOS-2 has a refractive all-spherical optical system providing 0.18-arcsecond pixels and a 6.2-arcminute circular field-of-view on a 2048x2048-pixel HAWAII-2 0.9-2.4 mm detector array. A slit/decker wheel mechanism allows the selection of up to 9 multi-object laser-machined plates or 3 long slits for spectroscopy over a 6x2-arcminute field of view, and selectable grisms provide resolutions from $\sim$ 1300 to $\sim $3000 over the entire spectrograph bandpass. FLAMINGOS-2 is also compatible with the Gemini Multi-Conjugate Adaptive Optics system, providing multi-object spectroscopic capabilities over a 3x1-arcminute field with high spatial resolution (0.09-arcsec/pixel). We review the designs of optical, mechanical, electronics, software, and On-Instrument WaveFront Sensor subsystems. We also present the current status of the project, currently in final testing in mid-2006., Comment: Submitted to SPIE Astronomical Telescopes & Instrumentation; 12 pages, incl. color figures

Published
2006
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40. The efficacy of mammography and screening for breast cancer

Author

Cotter, Gregory W., Corley, Richard D., Garver, Paul R., Tartar, Marie, Lim, Vivian, Hill, Linda, Ferrini, Rebecca, Mannino, Elizabeth, Ramsdell, Edith, Kattlove, Herman, Liberati, Alessandro, Keeler, Emmett, Brook, Robert H., Kerlikowske, Karla, Grady, Deborah, Rubin, Susan M., and Ernster, Virginia L.

Subjects
Breast cancer -- Care and treatment, Mammography
Published
1995

45. Repeated ingestion of 2-butoxyethanol: case report and literature review. (Case Report)

Author

Gualtieri, John F., DeBoer, Laresa, Harris, Carson R., and Corley, Richard

Subjects
Ethylene glycol -- Physiological aspects, Physiology, Pathological -- Research, Self-poisoning -- Case studies, Toxicological emergencies -- Case studies, Environmental issues, Health, Pharmaceuticals and cosmetics industries
Abstract

Background: Ethylene glycol monobutyl ether (2-butoxyethanol) is not commonly associated with significant human poisoning. Exposures are usually through occupational contact and typically involve inhalation injury. Animal studies report severe hemolysis occurring in rats and mice. Rare published human cases give varied descriptions of the clinical course associated with 2-butoxyethanol poisoning including reports of metabolic acidosis, ethylene glycol production, oxaluria, renal failure, and anemia. We report a case of two separate ingestions (80 to 100 grams) of a glass cleaner concentrate containing 22% 2-butoxyethanol, and its primary metabolite butoxyacetic acid. Case Report: An 18-year-old male ingested 360-480 mL of 22% 2-butoxyethanol on two separate occasions. Approximately 10 hours after the first ingestion, the patient developed severe CNS depression, metabolic acidosis, hematuria, and mild elevation of hepatic enzymes. He was treated initially with ethanol therapy but continued to deteriorate and was started on hemodialysis. Approximately 10 days after discharge, the patient ingested 480 mL of the same product and received ethanol and hemodialysis within four hours of ingestion. During his second admission the patient did not develop the delayed severe CNS depression or profound metabolic acidosis. Clinically significant hemolytic anemia, oxaluria, ethylene glycol production, and renal failure were not noted in either episode. The patient recovered on both occasions without sequelae. Conclusion: Hemodialysis may be an effective treatment intervention for managing severe acute 2-butoxyethanol intoxication; however, further investigation is warranted., INTRODUCTION Ethylene glycol monobutyl ether, also known as 2-butoxyethanol (BE), is a member of a family of glycol ethers that are used in a variety of industrial and household products. [...]

Published
2003

48. An integrated experimental-computational approach for predicting virulence in New Zealand white rabbits and humans following inhalation exposure to Bacillus anthracis spores

Author

Hess, Becky M., primary, Thomas, Dennis G., additional, Weber, Thomas J., additional, Hutchison, Janine R., additional, Straub, Timothy M., additional, Bruckner-Lea, Cynthia J., additional, Powell, Joshua D., additional, Kabilan, Senthil, additional, and Corley, Richard A., additional

Published
2019
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