3 results on '"Corigliano FG"'
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2. C-reactive protein induces tissue factor expression and promotes smooth muscle and endothelial cell proliferation
- Author
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Massimo Chiariello, Paolo Golino, Plinio Cirillo, Gaetano Calì, Paolo Calabrò, Lucio Nitsch, Massimo Ragni, Giovanni Cimmino, Fabio Granato Corigliano, Mario Pacileo, Salvatore De Rosa, Raffaele Spagnuolo, Annarita Gargiulo, Valeria Angri, Raffaele De Palma, Lavinia Forte, Cirillo, Plinio, Golino, P, Calabro, P, Cali, G, Ragni, M, De Rosa, S, Cimmino, G, Pacileo, M, De Palma, R, Forte, L, Gargiulo, A, Corigliano, Fg, Angri, V, Spagnuolo, R, Nitsch, Lucio, Chiariello, Massimo, Cirillo, P, Golino, Paolo, Calabro', Paolo, DE ROSA, S, Cimmino, Giovanni, DE PALMA, Raffaele, Nitsch, L, and Chiariello, M.
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MAPK/ERK pathway ,medicine.medical_specialty ,Cell type ,Endothelium ,Physiology ,Inflammation ,Muscle, Smooth, Vascular ,Thromboplastin ,Tissue factor ,c-reactive protein ,Physiology (medical) ,Internal medicine ,medicine ,Animals ,RNA, Messenger ,Extracellular Signal-Regulated MAP Kinases ,Cells, Cultured ,thrombosis ,Cell Proliferation ,Dose-Response Relationship, Drug ,biology ,Reverse Transcriptase Polymerase Chain Reaction ,Cell growth ,NF-kappa B ,Endothelial Cells ,Glyceraldehyde-3-Phosphate Dehydrogenases ,tissue factor ,Stimulation, Chemical ,Up-Regulation ,Cell biology ,Endothelial stem cell ,medicine.anatomical_structure ,Endocrinology ,Mitogen-activated protein kinase ,biology.protein ,Colorimetry ,Endothelium, Vascular ,Rabbits ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Signal Transduction - Abstract
Objective: Inflammation plays a pivotal role in atherothrombosis. In addition to being a prognostic marker for major cardiovascular events, recent data indicate that C-reactive protein (CRP) might directly promote atherothrombosis by exerting direct effects on vascular cells. The aim of the present study was to determine whether CRP might affect the prothrombotic and proliferative characteristics of endothelial (ECs) and smooth muscle cells (SMCs). Methods and results: Incubation of ECs and SMCs with CRP resulted in a dose-dependent activation of cell proliferation, which was mediated by activation of the p44/42 MAP Kinase (ERK 1/2) pathway. In addition, CRP also induced tissue factor (TF) expression in both cell types in a dose-dependent fashion, exerting its effect at the transcriptional level, as demonstrated by semiquantitative and by real time PCR. Activation of the transcription factor, NF-kappa B, by CRP was demonstrated by EMSA and by suppression of TF expression by the NF-kappa B inhibitor, pyrrolidine-dithio-carbamate ammonium. Conclusions: These data indicate that CRP exerts direct effects on ECs and SMCs by promoting proliferation and TF expression and support the notion that CRP, besides representing a marker of inflammation, is an effector molecule able to induce a pro-atherothrombotic phenotype in cells of the vessel wall. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
- Published
- 2005
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3. [Presence and severity of carotid atherosclerosis in asymptomatic hypertension patients with left ventricular hypertrophy].
- Author
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Guarini P, De Michele M, Tedeschi C, Accadia M, Giordano G, Corigliano FG, and Corigliano GG
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- Aged, Arteriosclerosis blood, Arteriosclerosis diagnostic imaging, Carotid Artery Diseases blood, Carotid Artery Diseases diagnostic imaging, Female, Humans, Hypertension blood, Hypertension diagnostic imaging, Hypertrophy, Left Ventricular blood, Hypertrophy, Left Ventricular diagnostic imaging, Lipids blood, Male, Middle Aged, Reproducibility of Results, Risk Factors, Ultrasonography, Ventricular Function, Left, Arteriosclerosis epidemiology, Carotid Artery Diseases epidemiology, Hypertension complications, Hypertrophy, Left Ventricular complications
- Abstract
Background and Purpose: Arterial hypertension is associated with structural changes in the cardiovascular system. In hypertensives, a relationship has been found between left ventricular hypertrophy and carotid wall thickness, whereas the association with atherosclerotic plaque is less defined. The aim of this study was to evaluate the occurrence and severity of carotid atherosclerosis in hypertensive patients with or without left ventricular hypertrophy (LVH)., Materials and Methods: We studied 122 hypertensive subjects (62 men and 60 women), aged 60.1 +/- 12.1. Subjects were considered to have left ventricular hypertrophy if their left ventricular mass index (LVMI) at echocardiography exceeded 110 g/m2 in women and 135 g/m2 in men. Carotid intima-media thickness (IMT), external diameter and atherosclerotic plaques were evaluated by high resolution echo-color Doppler., Results: IMT in both common carotid and bifurcation was significantly greater in hypertensives with LVH (p < 0.01), whereas external diameter did not differ significantly in the two groups. Increased presence (73.4 vs 32.8%) and severity (18.7 vs 5.2% for stenosis > 40%) of atherosclerotic plaque were found in the hypertrophic group. A weak but significant association was present among left ventricular mass index, ventricular wall thicknesses and carotid intima-media thickness, and plaque., Conclusions: In asymptomatic hypertensive subjects, LVH is associated with an increased risk of plaque formation and progression. Vascular hypertrophy may represent a distinct prognostic factor in hypertension and the association of cardiac and vascular hypertrophy may identify a group at high risk of future cardiovascular events.
- Published
- 1999
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