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3. Prevalence, incidence and clinical outcome of hepatitis B virus and hepatitis C virus hepatitis in patients undergoing allogeneic hematopoietic stem cell transplantation between 2001 and 2004.

Author

Francisci D, Aversa F, Coricelli V, Carotti A, Canovari B, Falcinelli F, Belfiori B, Aloisi T, Baldelli F, Martelli MF, and Stagni G

Subjects
Adolescent, Adult, Aged, Child, Hematopoietic Stem Cell Transplantation methods, Histocompatibility, Humans, Incidence, Lymphocyte Depletion, Middle Aged, Prevalence, Prospective Studies, Transplantation, Homologous, Treatment Outcome, Hematopoietic Stem Cell Transplantation adverse effects, Hepatitis B etiology, Hepatitis C etiology
Abstract

The prevalence, incidence and clinical course of viral hepatitis were prospectively determined in consecutive recipients of T-cell depleted hematopoieic stem cell transplants (49 mismatched, 60 matched, mean age 38 years; range 11-65). The prevalence of hepatitis B virus (HBV) was 15.6% and that of hepatitis C virus was 3.7% (HCV). HBV reactivated in one patient. Another developed ex novo acute hepatitis B which progressed to chronic hepatitis. There were no new cases of hepatitis C or worsening of pre-transplant HCV infections. HBV and HBC did not affect the outcome of T-cell depleted hematopoieic stem cell transplantation. Surveillance is important given the risk of HCV and HBV infection and/or reactivation and the efficacy of the new anti-hepatitis drugs.

Published
2006

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