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17 results on '"Cordon, Sally M"'

4. A comparative, randomised MRI study of the physiological and appetitive responses to gelling (alginate) and non-gelling nasogastric tube feeds in healthy men

Author

Aliyu, Abdulsalam I., primary, Nixon, Aline, additional, Hoad, Caroline L., additional, Marciani, Luca, additional, Corsetti, Maura, additional, Aithal, Guruprasad P., additional, Cordon, Sally M., additional, Macdonald, Ian A., additional, Alhussain, Maha H., additional, Inoue, Hiroaki, additional, Yamada, Masahiko, additional, and Taylor, Moira A., additional

Published
2023
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5. Effects of intermittent (5:2) or continuous energy restriction on basal and postprandial metabolism: a randomised study in normal-weight, young participants

Author

Gao, Yangfan, Tsintzas, Kostas, Macdonald, Ian A., Cordon, Sally M., and Taylor, Moira A.

Abstract

Background/objectives: Intermittent energy restriction (IER) may overcome poor long-term adherence with continuous energy restriction (CER), for weight reduction. We compared the effects of IER with CER for fasting and postprandial metabolism and appetite in metabolically healthy participants, in whom excess weight would not confound intrinsic metabolic differences. Subjects/methods: In a 2-week randomised, parallel trial, 16 young, healthy-weight participants were assigned to either CER (20% below estimated energy requirements (EER)) or 5:2 IER (70% below EER on 2 non-consecutive days; 5 days at EER, per week). Metabolic and appetite regulation markers were assessed before and for 3 h after a liquid breakfast; followed by an ad libitum lunch; pre- and post-intervention. Results: Weight loss was similar in both groups: −2.5 (95% CI, −3.4, −1.6) kg for 5:2 IER vs. −2.3 (−2.9, −1.7) kg for CER. There were no differences between groups for postprandial incremental area under the curve for serum insulin, blood glucose or subjective appetite ratings. Compared with CER, 5:2 IER led to a reduction in fasting blood glucose concentrations (treatment-by-time interaction, P= 0.018, η2p= 0.14). Similarly, compared with CER, there were beneficial changes in fasting composite appetite scores after 5:2 IER (treatment-by-time interaction, P= 0.0003, η2p= 0.35). Conclusions: There were no significant differences in postprandial insulinaemic, glycaemic or appetite responses between treatments. However, 5:2 IER resulted in greater improvements in fasting blood glucose, and beneficial changes in fasting subjective appetite ratings.

Published
2024
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6. Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization

Author

Shur, Natalie F., primary, Simpson, Elizabeth J., additional, Crossland, Hannah, additional, Chivaka, Prince K., additional, Constantin, Despina, additional, Cordon, Sally M., additional, Constantin‐Teodosiu, Dumitru, additional, Stephens, Francis B., additional, Lobo, Dileep N., additional, Szewczyk, Nate, additional, Narici, Marco, additional, Prats, Clara, additional, Macdonald, Ian A., additional, and Greenhaff, Paul L., additional

Published
2022
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8. Human adaptation to immobilization:Novel insights of impacts on glucose disposal and fuel utilization

Author

Shur, Natalie F., Simpson, Elizabeth J., Crossland, Hannah, Chivaka, Prince K., Constantin, Despina, Cordon, Sally M., Constantin-Teodosiu, Dumitru, Stephens, Francis B., Lobo, Dileep N., Szewczyk, Nate, Narici, Marco, Prats, Clara, Macdonald, Ian A., Greenhaff, Paul L., Shur, Natalie F., Simpson, Elizabeth J., Crossland, Hannah, Chivaka, Prince K., Constantin, Despina, Cordon, Sally M., Constantin-Teodosiu, Dumitru, Stephens, Francis B., Lobo, Dileep N., Szewczyk, Nate, Narici, Marco, Prats, Clara, Macdonald, Ian A., and Greenhaff, Paul L.

Abstract

Background: Bed rest (BR) reduces whole-body insulin-stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly when volunteers are maintained in energy balance. Methods: Healthy males (n = 10, 24.0 ± 1.3 years), maintained in energy balance, underwent 3-day BR (acute BR). A second cohort matched for sex and body mass index (n = 20, 34.2 ± 1.8 years) underwent 56-day BR (chronic BR). A hyperinsulinaemic euglycaemic clamp (60 mU/m2/min) was performed to determine rates of whole-body insulin-stimulated GD before and after BR (normalized to lean body mass). Indirect calorimetry was performed before and during steady state of each clamp to calculate rates of whole-body fuel oxidation. Muscle biopsies were taken to determine muscle glycogen, metabolite and intramyocellular lipid (IMCL) contents, and the expression of 191 mRNA targets before and after BR. Two-way repeated measures analysis of variance was used to detect differences in endpoint measures. Results: Acute BR reduced insulin-mediated GD (Pre 11.5 ± 0.7 vs. Post 9.3 ± 0.6 mg/kg/min, P < 0.001), which was unchanged in magnitude following chronic BR (Pre 10.2 ± 0.4 vs. Post 7.9 ± 0.3 mg/kg/min, P < 0.05). This reduction in GD was paralleled by the elimination of the 35% increase in insulin-stimulated muscle glycogen storage following both acute and chronic BR. Acute BR had no impact on insulin-stimulated carbohydrate (CHO; Pre 3.69 ± 0.39 vs. Post 4.34 ± 0.22 mg/kg/min) and lipid (Pre 1.13 ± 0.14 vs. Post 0.59 ± 0.11 mg/kg/min) oxidation, but chronic BR reduced CHO oxidation (Pre 3.34 ± 0.18 vs. Post 2.72 ± 0.13 mg/kg/min, P < 0.05) and blunted the magnitude of insulin-mediated inhibition of lipid oxidation (Pre 0.60 ± 0.07 vs. Post 0.85 ± 0.06 mg/kg/min, P < 0.05). Neither acute nor chronic BR increased muscle IMCL content. Plentiful mRNA abundance changes were dete

Published
2022

10. sj-pdf-1-jcb-10.1177_0271678X221082911 - Supplemental material for Altered functional connectivity during hypoglycaemia in type 1 diabetes

Author

Jacob, Peter, Nwokolo, Munachiso, Cordon, Sally M, Macdonald, Ian A, Zelaya, Fernando O, Amiel, Stephanie A, O���Daly, Owen, and Choudhary, Pratik

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221082911 for Altered functional connectivity during hypoglycaemia in type 1 diabetes by Peter Jacob, Munachiso Nwokolo, Sally M Cordon, Ian A Macdonald, Fernando O Zelaya, Stephanie A Amiel, Owen O���Daly and Pratik Choudhary in Journal of Cerebral Blood Flow & Metabolism

Published
2022
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13. Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans

Author

Alyami, Jaber, Whitehouse, Ella, Yakubov, Gleb E, Pritchard, Susan E, Hoad, Caroline L, Blackshaw, Elaine, Heissam, Khaled, Cordon, Sally M, Bligh, H Frances J, Spiller, Robin C, Macdonald, Ian A, Aithal, Guruprasad P, Gowland, Penny A, Taylor, Moira A, and Marciani, Luca

Subjects
Breakfast porridges, cereal grains, blood glucose, gastric emptying, magnetic resonance imaging, appetite, Bio/Medical/Health - Physiology, Global Research Theme - Health and Wellbeing, digestive, oral, and skin physiology, food and beverages, Beacon - Precision Imaging
Abstract

Whole grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known about its health effects. This study investigated the effect of a pearl millet porridge (PMP) compared with a well-known Scottish oats porridge (SOP) on glycaemic, gastrointestinal, hormonal and appetitive responses. In a randomized, two way crossover trial, 26 healthy participants consumed two iso-energetic/volumetric PMP or SOP breakfast meals, served with a drink of water. Blood samples for glucose, insulin, GLP-1, GIP and PYY, gastric volumes and appetite ratings were collected for two hours postprandially, followed by an ad libitum meal and food intake records for the remainder of the day. The incremental area under the curve (iAUC2h) for blood glucose was not significantly different between the porridges (p ? 0.05). The iAUC2h gastric volume was larger for PMP compared with SOP (p = 0.045). The iAUC2h GIP concentration was significantly lower for PMP compared with SOP (p = 0.001). Other hormones and appetite responses were similar between meals. In conclusion, this study reports, for the first time, data on glycaemic and physiological responses to a pearl millet breakfast, showing that this ancient grain could represent a sustainable, alternative, with health-promoting characteristics comparable to oats. GIP is an incretin hormone linked to triacylglycerol absorption in adipose tissue, therefore the lower GIP response for PMP may be an added health benefit.

Published
2019

17. Glycaemic, gastrointestinal, hormonal and appetitive responses to pearl millet or oats porridge breakfasts: a randomised, crossover trial in healthy humans.

Author

Alyami J, Whitehouse E, Yakubov GE, Pritchard SE, Hoad CL, Blackshaw E, Heissam K, Cordon SM, Bligh HFJ, Spiller RC, Macdonald IA, Aithal GP, Gowland PA, Taylor MA, and Marciani L

Subjects
Adult, Cross-Over Studies, Female, Humans, Male, Young Adult, Appetite drug effects, Avena, Blood Glucose, Breakfast, Gastrointestinal Motility drug effects, Pennisetum
Abstract

Whole-grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known about its health effects. The present study investigated the effect of a pearl millet porridge (PMP) compared with a well-known Scottish oats porridge (SOP) on glycaemic, gastrointestinal, hormonal and appetitive responses. In a randomised, two-way crossover trial, twenty-six healthy participants consumed two isoenergetic/isovolumetric PMP or SOP breakfast meals, served with a drink of water. Blood samples for glucose, insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide (GIP), peptide YY, gastric volumes and appetite ratings were collected 2 h postprandially, followed by an ad libitum meal and food intake records for the remainder of the day. The incremental AUC (iAUC2h) for blood glucose was not significantly different between the porridges (P > 0·05). The iAUC2h for gastric volume was larger for PMP compared with SOP (P = 0·045). The iAUC2h for GIP concentration was significantly lower for PMP compared with SOP (P = 0·001). Other hormones and appetite responses were similar between meals. In conclusion, the present study reports, for the first time, data on glycaemic and physiological responses to a pearl millet breakfast, showing that this ancient grain could represent a sustainable alternative with health-promoting characteristics comparable with oats. GIP is an incretin hormone linked to TAG absorption in adipose tissue; therefore, the lower GIP response for PMP may be an added health benefit.

Published
2019
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