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1. Ocular sequelae of epidermal necrolysis: French national audit of practices, literature review and proposed management

Author

Thorel, Dhyna, Ingen-Housz-Oro, Saskia, Benaïm, Daniel, Daien, Vincent, Gabison, Eric, Saunier, Valentine, Béral, Laurence, Touboul, David, Brémond-Gignac, Dominique, Robert, Matthieu, Vasseur, Robin, Royer, Gérard, Dereure, Olivier, Milpied, Brigitte, Bernier, Claire, Welfringer-Morin, Anne, Bodemer, Christine, Cordel, Nadège, Tauber, Marie, Burillon, Carole, Servant, Marion, Couret, Chloe, Vabres, Bertrand, Tétart, Florence, Cassagne, Myriam, Kuoch, Marie-Ange, Muraine, Marc, Delcampe, Agnès, and Gueudry, Julie

Published
2023
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2. TIF1-gamma IgG2 isotype is not associated with malignancy in juvenile dermatomyositis patients.

Author

Nguyen, Huong D, Jouen, Fabienne, Déchelotte, Benoit, Cordel, Nadège, Gitiaux, Cyril, Bodemer, Christine, Quartier, Pierre, Belot, Alexandre, O'Brien, Kathryn, Cancemi, Dario, Melki, Isabelle, Fabien, Nicole, Tansley, Sarah, Boyer, Olivier, Wedderburn, Lucy R, Bader-Meunier, Brigitte, and Study, UK JDM Cohort and Biomarker

Subjects
DERMATOMYOSITIS, IMMUNOGLOBULINS, AUTOANTIBODIES, TRANSCRIPTION factors, TUMORS, BIOMARKERS, CHILDREN
Abstract

The article discusses research which investigated the link between anti-transcriptional intermediary factor 1 (TIF1) gamma immunoglobulin G2 (IgG2) isotype and cancer in patients with juvenile dermatomyositis (JDM). Topics explored include the evaluation of the clinical conditions of anti-TIF1 gamma-positive patients, the anti-TIF1 gamma-IgG2 prevalence observed among ethnic groups, and the reported lack of connection between anti-TIF1 gamma-IgG2 and malignancy in concerned patients.

Published
2024
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5. Auteurs

Author

Akakpo, Agbemegnan Claude, primary, Baubion, Émilie, additional, Bertolotti, Antoine, additional, Bonniol, Jean-Luc, additional, Bouchaud, Olivier, additional, Cabotin, Pierre-Patrice, additional, Caumes, Éric, additional, Comte, Christelle, additional, Cordel, Nadège, additional, Couppié, Pierre, additional, Deligny, Christophe, additional, Faye, Ousmane, additional, Goettmann-Bonvallot, Sophie, additional, Génin, Emmanuelle, additional, Gessain, Antoine, additional, Hali, Fouzia, additional, Ghorbel, Houda Hammami, additional, Hoareau, Florence, additional, Jaffré, Yannick, additional, Kluger, Nicolas, additional, Lebrun-Vignes, Bénédicte, additional, Lenormand, Cédric, additional, Louis-Sidney, Fabienne, additional, Mahé, Antoine, additional, Petit, Antoine, additional, Pham, Félix, additional, Pitché, Palokinam, additional, Saka, Bayaki, additional, Senet, Patricia, additional, Smadja, Jack, additional, Suzon, Benoît, additional, and Thomas, Luc, additional

Published
2022
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6. New human in vitro co‐culture model of keratinocytes and sensory neurons like cells releasing substance P with an evaluation of the expression of ZIKV entry receptors: A potent opportunity to test Zika virus entry and to study Zika virus' infection in neurons?

Author

Bocciarelli, Claire, primary, Cordel, Nadège, additional, Leschiera, Raphael, additional, Talagas, Matthieu, additional, Le Gall‐Ianotto, Christelle, additional, Hu, Weiguo, additional, Marcorelles, Pascale, additional, Bellemere, Gaëlle, additional, Bredif, Stéphanie, additional, Fluhr, Joachim, additional, Misery, Laurent, additional, and Lebonvallet, Nicolas, additional

Published
2023
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7. Anti-SAE autoantibody in dermatomyositis: original comparative study and review of the literature.

Author

Demortier, Juliette, Vautier, Mathieu, Chosidow, Olivier, Gallay, Laure, Bessis, Didier, Berezne, Alice, Cordel, Nadège, Schmidt, Jean, Smail, Amar, Duffau, Pierre, Jachiet, Marie, Begon, Edouard, Gottlieb, Jeremy, Chasset, François, Graveleau, Julie, Marque, Myriam, Cesbron, Elise, Forestier, Amandine, Josse, Séverine, and Kluger, Nicolas

Subjects
TUMOR risk factors, AUTOANTIBODIES, MUSCLE diseases, DERMATOMYOSITIS, SCIENTIFIC observation, BIOPSY, MUSCLES, RETROSPECTIVE studies, ACQUISITION of data, EXANTHEMA, INTERSTITIAL lung diseases, COMPARATIVE studies, DYSPNEA, INTRAVENOUS immunoglobulins, MUSCLE weakness, RISK assessment, DISEASE prevalence, MEDICAL records, DESCRIPTIVE statistics, CALCINOSIS, MYOSITIS, ENZYME inhibitors, NECROSIS, DISEASE complications
Abstract

Objective Among specific autoantibodies in DM, the anti–small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE–positive DM. Methods Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study. The available muscular biopsies were reviewed. We conducted a comparison with anti-SAE–negative DM and a review of the literature. Results Of the patients in the study (n  = 49), 84% were women. Skin involvement was typical in 96% of patients, with 10% having calcinosis, 18% ulceration and 12% necrosis; 35% presented with a widespread skin rash. Muscular disease affected 84% of patients, with mild weakness [Medical Research Council (MRC) scale 4 (3, 5)], although 39% of patients had dysphagia. Muscular biopsies showed typical DM lesions. Interstitial lung disease was found in 21% of patients, mainly with organizing pneumonia pattern, and 26% of patients showed dyspnoea. Cancer-associated myositis was diagnosed in 16% of patients and was responsible for the majority of deaths, its prevalence being five times that of the general population. IVIG therapy was administered to 51% of the patients during the course of the disease. Comparison with anti-SAE–negative DM (n  = 85) showed less and milder muscle weakness (P  = 0.02 and P  = 0.006, respectively), lower creatinine kinase levels (P  < 0.0001) and less dyspnoea (P  = 0.003). Conclusion Anti-SAE positive DM is a rare subgroup associated with typical skin features but a potentially diffuse rash, a mild myopathy. Interstitial lung disease defines an organizing pneumonia pattern. Cancer associated DM prevalence is five times that of the general population. Trial registration ClinicalTrials.gov, http://clinicaltrials.gov , NCT04637672. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Anti-transcription intermediary factor 1-gamma IgG2 isotype is associated with cancer in adult dermatomyositis: an ENMC multinational study

Author

Cordel, Nadège, primary, Dechelotte, Benoît, additional, Jouen, Fabienne, additional, Lamb, Janine A, additional, Chinoy, Hector, additional, New, Paul, additional, Vencovsky, Jiri, additional, Mann, Herman, additional, Galindo-Feria, Angeles S, additional, Dani, Lara, additional, Selva-O’Callaghan, Albert, additional, Werth, Victoria P, additional, Ravishankar, Adarsh, additional, Landon-Cardinal, Océane, additional, Tressières, Benoit, additional, and Boyer, Olivier, additional

Published
2022
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9. Anti‐BP180 IgG antibody ELISA values correlate with adverse pregnancy outcomes in pemphigoid gestationis.

Author

Cordel, Nadège, Flament, Jasmine, Jouen, Fabienne, Seta, Vannina, Tancrède‐Bohin, Emmanuelle, Dahan, Catherine Picard, Konstantinou, Maria‐Polina, Dereure, Olivier, Quéreux, Gaëlle, Prost, Catherine, Bedane, Christophe, Debarbieux, Sébastien, Lacour, Jean‐Philippe, Dompmartin, Anne, Wierzbicka‐Hainaut, Ewa, Villada, Isabelle Bourgault, Oro, Saskia Ingen Housz, Vabres, Pierre, Richard, Marie‐Aleth, and Delaporte, Emmanuel

Subjects
*PREGNANCY outcomes, *SMALL for gestational age, *FETAL growth retardation, *IMMUNOGLOBULIN G, *PREMATURE labor
Abstract

Background: Adverse pregnancy outcomes (APO) occur in 35% of patients with pemphigoid gestationis (PG). No biological predictor of APO has been established yet. Objectives: To assess a potential relationship between the occurrence of APO and the serum value of anti‐BP180 antibodies at the time of PG diagnosis. Methods: Multicentre retrospective study conducted from January 2009 to December 2019 in 35 secondary and tertiary care centres. Inclusion criteria: (i) diagnosis of PG according to clinical, histological and immunological criteria, (ii) ELISA measurement of anti‐BP180 IgG antibodies determined at the time of PG diagnosis with the same commercial kit and (iii) obstetrical data available. Results: Of the 95 patients with PG included, 42 had one or more APO, which mainly corresponded to preterm birth (n = 26), intrauterine growth restriction (IUGR) (n = 18) and small weight for gestational age at birth (n = 16). From a ROC curve, we identified a threshold of 150 IU ELISA value as the most discriminating to differentiate between patients with or without IUGR, with 78% sensitivity, 55% specificity, 30% positive and 91% negative predictive value. The threshold >150 IU was confirmed using a cross‐validation based on bootstrap resampling, which showed that the median threshold was 159 IU. Upon adjusting for oral corticosteroid intake and main clinical predictors of APO, an ELISA value of >150 IU was associated with the occurrence of IUGR (OR = 5.11; 95% CI: 1.48–22.30; p = 0.016) but not with any other APO. The combination of blisters and ELISA values higher than 150 IU led to a 2.4‐fold higher risk of all‐cause APO (OR: 10.90; 95% CI: 2.33–82.3) relative to patients with blisters but lower values of anti‐BP180 antibodies (OR of 4.54; 95% CI 0.92–34.2). Conclusion: These findings suggest that anti‐BP180 antibody ELISA value in combination with clinical markers is helpful in managing the risk of APO, in particular IUGR, in patients with PG. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Hydroxychloroquine dose tapering or discontinuation in cutaneous lupus erythematosus after remission: A retrospective multicenter cohort study of 56 patients

Author

Sonigo, Gabrielle, primary, Jachiet, Marie, additional, Bessis, Didier, additional, Cordel, Nadège, additional, Faucon, Caroline, additional, Petit, Antoine, additional, Cordoliani, Florence, additional, Bagot, Martine, additional, Senet, Patricia, additional, Barbaud, Annick, additional, Bouaziz, Jean-David, additional, Francès, Camille, additional, and Chasset, François, additional

Published
2022
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11. Male sex, discoid lupus erythematosus, and lower limb involvement are associated with systemic lupus in lupus panniculitis patients: A multicenter case series of 74 patients

Author

Lemasson, Juliette, primary, Frumholtz, Laure, additional, Jachiet, Marie, additional, Lenormand, Cédric, additional, Lipsker, Dan, additional, Moulin, Sophie, additional, Chiaverini, Christine, additional, Le Duff, Florence, additional, Passeron, Thierry, additional, Cordoliani, Florence, additional, Bagot, Martine, additional, Monfort, Jean-Benoît, additional, Senet, Patricia, additional, De Masson, Adèle, additional, Cassius, Charles, additional, Petit, Antoine, additional, Misery, Laurent, additional, Moguelet, Philippe, additional, Cordel, Nadège, additional, Fardet, Laurence, additional, Begon, Edouard, additional, Frances, Camille, additional, Bessis, Didier, additional, Bouaziz, Jean-David, additional, and Chasset, François, additional

Published
2022
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12. Real-life impact of immunologic tests to predict relapse after treatment cessation in patients with bullous pemphigoid: A French multicenter retrospective study

Author

Battesti, Gilles, primary, Garcia, Charline, additional, Viguier, Manuelle, additional, Marchal, Valentine, additional, Castel, Marion, additional, Joly, Pascal, additional, Ledard, Anne-Pham, additional, Konstantinou, Maria-Polina, additional, Seta, Vannina, additional, Cordel, Nadège, additional, Duvert-Lehembre, Sophie, additional, Tancrède-Bohin, Emmanuelle, additional, Belmondo, Thibaut, additional, Ingen-Housz-Oro, Saskia, additional, and d’Incan, Michel, additional

Published
2022
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13. Anti-transcription intermediary factor 1-gamma IgG2 isotype is associated with cancer in adult dermatomyositis: an ENMC multinational study.

Author

Cordel, Nadège, Dechelotte, Benoît, Jouen, Fabienne, Lamb, Janine A, Chinoy, Hector, New, Paul, Vencovsky, Jiri, Mann, Herman, Galindo-Feria, Angeles S, Dani, Lara, Selva-O'Callaghan, Albert, Werth, Victoria P, Ravishankar, Adarsh, Landon-Cardinal, Océane, Tressières, Benoit, and Boyer, Olivier

Subjects
*TUMOR risk factors, *AUTOANTIBODIES, *DERMATOMYOSITIS, *RETROSPECTIVE studies, *GAMMA globulins, *RISK assessment, *IMMUNOASSAY, *CANCER patients, *ENZYME-linked immunosorbent assay, *DESCRIPTIVE statistics, *TRANSCRIPTION factors, *TUMOR markers, *CRYOPRESERVATION of organs, tissues, etc., *CHEMICAL inhibitors, *ADULTS
Abstract

Objective To assess the role of the anti-TIF1γ auto-antibody (aAb) IgG2 isotype as a biomarker of cancer in anti-TIF1γ aAb-positive adult DM. Methods International multicentre retrospective study with the following inclusion criteria: (i) diagnosis of DM according to ENMC criteria; (ii) presence of anti-TIF1γ IgG aAb determined using an in-house addressable laser bead immunoassay (ALBIA) from cryopreserved serums sampled at time of DM diagnosis and (iii) available baseline characteristics and follow-up data until the occurrence of cancer and/or a minimum follow-up of 1 year for patients without known cancer at diagnosis. Detection and quantification of anti-TIF1γ IgG2 aAb was done using the in-house ALBIA. In addition, a recent ELISA commercial kit was used for anti-TIF1γ IgG aAb quantification. Results A total of 132 patients (mean age 55±15 years) of whom 72 (54.5%) had an associated cancer were analysed. The association between the presence of cancer and the presence of anti-TIF1γ IgG2 aAb was statistically significant (P  = 0.026), with an OR of 2.26 (95% CI: 1.10, 4.76). Patients with cancer displayed significantly higher anti-TIF1γ IgG2 aAb ALBIA values with a median value of 1.15 AU/ml (IQR: 0.14–9.76) compared with 0.50 AU/ml (IQR: 0.14–1.46) for patients without cancer (P  = 0.042). In addition, patients with cancer displayed significantly higher anti-TIF1γ IgG aAb ELISA values with a median value of 127.5 AU/ml (IQR: 81.5–139.6) compared with 93.0 AU/ml (IQR: 54.0–132.9) for patients without cancer (P  = 0.004). Conclusion These results suggest considering anti-TIF1γ IgG2 ALBIA and IgG ELISA values as biomarkers of cancer in anti-TIF1 γ aAb-positive adult DM. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Incidence and severity of COVID-19 in patients with autoimmune blistering skin diseases: A nationwide study

Author

Joly, Pascal, primary, Gillibert, André, additional, Bohelay, Gérôme, additional, Aouar, Karen, additional, Ingen-Housz-Oro, Saskia, additional, Bedane, Christophe, additional, Lepelletier, Clémence, additional, Bohin, Emmanuelle Tancrède, additional, Viguier, Manuelle, additional, Dupin, Nicolas, additional, Debarbieux, Sebastien, additional, Jullien, Denis, additional, Quereux, Gaelle, additional, Morice, Cécile, additional, Mahe, Antoine, additional, Michel, Catherine, additional, Litrowski, Noemie, additional, Jeudy, Géraldine, additional, Richard, Marie Aleth, additional, Picard, Catherine, additional, Chosidow, Olivier, additional, Ledard, Anne-Pham, additional, Hebert, Vivien, additional, Duvert-Lehembre, Sophie, additional, Cordel, Nadège, additional, Alexandre, Marina, additional, Le Roux-Villet, Christelle, additional, and Caux, Frédéric, additional

Published
2022
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16. Impact en vie réelle des tests immunologiques de la pemphigoïde bulleuse dans la décision d’arrêt du traitement et les rechutes

Author

Battesti, Gilles, primary, Garcia, Charline, additional, Marchal, Valentine, additional, Viguier, Manuelle, additional, Castel, Marion, additional, Joly, Pascal, additional, Pham-Ledard, Anne, additional, Konstantinou, Maria-Polina, additional, Seta, Vannina, additional, Cordel, Nadège, additional, Duvert-Lehembre, Sophie, additional, Tancrède-Bohin, Emmanuelle, additional, Belmondo, Thibaut, additional, Oro, Saskia, additional, and d’Incan, Michel, additional

Published
2021
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17. Pemphigus avec dépôts d’IgA : étude rétrospective de 14 cas comparant les formes à dépôts d’IgA seuls versus IgA+IgG

Author

Calmettes, Vincent, primary, Badrignans, Marine, additional, Konstantinou, Maria Polina, additional, Tancrède-Bohin, Emmanuelle, additional, Vignon-Pennamen, Marie Dominique, additional, Castel, Marion, additional, Pham-Ledard, Anne, additional, Le Roux-Villet, Christelle, additional, Misery, Laurent, additional, Schoenlaub, Patricia, additional, Tronquoy, Anne-Fleur, additional, Cordel, Nadège, additional, Ortonne, Nicolas, additional, Aractingi, Sélim, additional, Duvert-Lehembre, Sophie, additional, Dupin, Nicolas, additional, and Oro, Saskia, additional

Published
2021
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18. Prise en charge des séquelles ophtalmologiques de la nécrolyse épidermique. Audit national des pratiques

Author

Thorel, Dhyna, primary, Oro, Saskia, additional, Benaïm, Daniel, additional, Daien, Vincent, additional, Gabison, Eric, additional, Saunier, Valentine, additional, Béral, Laurence, additional, Touboul, David, additional, Brémond-Gignac, Dominique, additional, Robert, Matthieu, additional, Vasseur, Robin, additional, Royer, Gérard, additional, Dereure, Olivier, additional, Milpied, Brigitte, additional, Bernier, Claire, additional, Welfringer, Anne, additional, Bodemer, Christine, additional, Cordel, Nadège, additional, Tauber, Marie, additional, Tétart, Florence, additional, Cassagne, Myriam, additional, Kunvari Kuoch, Marie Ange, additional, Muraine, Marc, additional, Delcampe, Agnes, additional, and Gueudry, Julie, additional

Published
2021
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19. Diminution et arrêt de l’hydroxychloroquine dans le lupus érythémateux cutané après rémission : une étude rétrospective multicentrique de 56 cas

Author

Sonigo, Gabrielle, primary, Jachiet, Marie, additional, Bessis, Didier, additional, Cordel, Nadège, additional, Faucon, Caroline, additional, Petit, Antoine, additional, Cordoliani, Florence, additional, Bagot, Martine, additional, Senet, Patricia, additional, Barbaud, Annick, additional, Bouaziz, Jean David, additional, Frances, Camille, additional, and Chasset, François, additional

Published
2021
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21. La dermatomyosite à type de pseudo dermatite séborrhéique est-elle associée à une pneumopathie interstitielle diffuse ?

Author

Cordel, Nadège, primary, Cassius, Charles, additional, Best, Marion, additional, Jullien, Denis, additional, Martin, Ludovic, additional, Jachiet, Marie, additional, Chasset, François, additional, Pallure, Valérie, additional, Bergeret, Blanche, additional, Bouaziz, Jean David, additional, Tressières, Benoit, additional, Lenormand, Cédric, additional, and Bessis, Didier, additional

Published
2021
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24. TRIM33 gene somatic mutations identified by next generation sequencing in neoplasms of patients with anti-TIF1γ positive cancer-associated dermatomyositis

Author

Cordel, Nadège, Derambure, Céline, Coutant, Sophie, Mariette, Xavier, Jullien, Denis, Debarbieux, Sébastien, Chosidow, Olivier, Meyer, Alain, Bessis, Didier, Joly, Pascal, Mathian, Alexis, Levesque, Hervé, Sabourin, Jean-Christophe, Tournier, Isabelle, Boyer, Olivier, Amoura, Zahir, Aouizerate, Jessie, Benveniste, Olivier, Brocheriou, Isabelle, Dechelotte, Benoît, Graveleau, Julie, Guerzider, Pascale, Isaac, Sylvie, Kanitakis, Jean, Lannes, Béatrice, Lazure, Thierry, Rigau, Valérie, Sibilia, Jean, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Hôpital Henri Mondor, Dynamic Microbiology - EA 7380 (DYNAMIC), École nationale vétérinaire - Alfort (ENVA)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Université Paris-Est (UPE)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Strasbourg, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Université des Antilles (UA)-Etablissement français du don du sang [Montpellier], CHU Rouen, Normandie Université (NU), Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière] (DMIIC), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut E3M [CHU Pitié-Salpêtrière], Service de Médecine Interne [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Institut des Neurosciences de Montpellier (INM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
0301 basic medicine, Myositis and muscle disease, Male, Somatic cell, DNA Mutational Analysis, Disease, Gene mutation, MESH: Dermatomyositis, 0302 clinical medicine, Neoplasms, Medicine, Pharmacology (medical), MESH: Neoplasms, MESH: DNA Mutational Analysis, MESH: High-Throughput Nucleotide Sequencing, Skin, MESH: Aged, MESH: DNA, High-Throughput Nucleotide Sequencing, Zinc Fingers, MESH: Transcription Factors, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Muscle, Female, MESH: Mutation, DNA sequencing, Dermatomyositis, 03 medical and health sciences, Rheumatology, Genetics, MESH: Zinc Fingers, Humans, Gene, Aged, 030203 arthritis & rheumatology, MESH: Humans, Neoplasia, business.industry, Cancer, DNA, medicine.disease, TRIM33, MESH: Male, 030104 developmental biology, Mutation, Cancer research, business, MESH: Female, Transcription Factors
Abstract

Objective To deep sequence the TRIM33 gene in tumours from patients with cancer-associated anti-TIF1γ autoantibody-positive dermatomyositis (DM) as TRIM33 somatic mutations in tumours may trigger this auto-immune disease. Methods Next generation sequencing of tumour DNA samples from patients with cancer-associated anti-TIF1γ autoantibody-positive DM. Fourteen tumours from 13 anti-TIF1γ autoantibody-positive DM individuals were sequenced along with two control tumours from non-DM individuals. Results Fourteen probable somatic variants from four tumours were identified in the TRIM33 gene. Conclusion These results are in accordance with the previous report of Pinal-Fernandez et al. and support the hypothesis of a role of TRIM33 gene mutations in the pathophysiology of anti-TIF1γ autoantibody-positive DM.

Published
2021

29. Incidence and Mortality of Pemphigus in France

Author

Jelti, Lamia, Cordel, Nadège, Gillibert, André, Lacour, Jean-Philippe, Uthurriague, Claire, Doutre, Marie-Sylvie, Delaporte, Emmanuel, Duvert-Lehembre, Sophie, Quereux, Gaelle, Dupuy, Alain, Adamski, Henri, Bedane, Christophe, Misery, Laurent, Abasq Thomas, Claire, Fleuret, Camille, Bernard, Philippe, Chaby, Guillaume, D'incan, Michel, Verneuil, Laurence, Litrowski, Noemie, and Joly, Pascal

Published
2019
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30. The IgG2 isotype of anti-transcription intermediary factor 1-gamma autoantibodies is a biomarker of mortality and cancer in adult dermatomyositis

Author

Aussy, Audrey, Fréret, Manuel, Gallay, Laure, Drouot, Laurent, Jouen, Fabienne, Allenbach, Yves, Benveniste, Olivier, Cordel, Nadège, Boyer, Olivier, Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2019

31. Incidence and Mortality of Pemphigus in France

Author

Minocha, Rashi, Martin, Andrew, Chen, Andrew, Scolyer, Richard, Lyons, J, Mckenzie, Catriona, Madore, Jason, Halliday, Gary, Damian, Diona, Ns, Agar, Gm, Halliday, Rs, Barnetson, Hn, Ananthaswamy, Ac, Chen, Aj, Martin, Jelti, Lamia, Cordel, Nadège, Gillibert, André, Lacour, Jean-Philippe, Uthurriague, Claire, Doutre, Marie-Sylvie, Delaporte, Emmanuel, Duvert-Lehembre, Sophie, Quereux, Gaelle, Dupuy, Alain, Adamski, Henri, Bedane, Christophe, Misery, Laurent, Abasq Thomas, Claire, Fleuret, Camille, Bernard, Philippe, Chaby, Guillaume, D'Incan, Michel, Verneuil, Laurence, Litrowski, Noemie, Joly, Pascal, Centre Hospitalier Universitaire de Reims (CHU Reims), Immuno-Régulation dans les Maladies Auto-Immunes Inflammatoires et le Cancer - EA 7509 (IRMAIC), and Université de Reims Champagne-Ardenne (URCA)

Subjects
integumentary system, sense organs, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; AM. The basal layer in human squamous tumors harbors more UVA than UVB fingerprint mutations: a role for UVA in human skin carcinogenesis. Proc Natl Acad Sci USA 2004;101:4954e9. Bostom AG, Merhi B, Walker J, Robinson-Bostom L. More than skin deep? Potential nicotinamide treatment applications in chronic kidney transplant recipients. World J Transpl 2016;6:658e64.

Published
2019

34. Risk of thromboembolic events in patients treated with thalidomide for cutaneous lupus erythematosus: A multicenter retrospective study

Author

Cesbron, Elise, Bessis, Didier, Jachiet, Marie, Lipsker, Dan, Cordel, Nadège, Bouaziz, Jean-David, Bagot, Martine, Arnaud, Laurent, Barbaud, Annick, Francès, Camille, chasset, françois, Étude des Maladies Systémiques en Dermatologie, EMSED, Service de dermatologie et allergologie [CHU Tenon], CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Service de Dermatologie [AP-HP Hôpital Saint-Louis], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Diderot - Paris 7 (UPD7), CHU Strasbourg, Université de Strasbourg (UNISTRA), CHU Pointe-à-Pitre/Abymes [Guadeloupe], Université des Antilles (Pôle Guadeloupe), Université des Antilles (UA), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de rhumatologie [Strasbourg], CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Immuno-Rhumatologie Moléculaire, and Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Adult, Male, medicine.medical_specialty, Dermatology, Risk Assessment, Severity of Illness Index, Drug Administration Schedule, Cohort Studies, Hospitals, University, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Age Distribution, Thromboembolism, Severity of illness, Lupus Erythematosus, Cutaneous, Medicine, Humans, Sex Distribution, Survival rate, ComputingMilieux_MISCELLANEOUS, Aged, Retrospective Studies, 030203 arthritis & rheumatology, Lupus erythematosus, Dose-Response Relationship, Drug, business.industry, Incidence (epidemiology), Incidence, Retrospective cohort study, Middle Aged, medicine.disease, 3. Good health, Thalidomide, Survival Rate, Female, France, business, Risk assessment, Immunosuppressive Agents, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Cohort study, medicine.drug, Follow-Up Studies
Abstract

International audience

Published
2018

36. Étude comparative de la mortalité des patients atteints de pemphigus selon l’utilisation du rituximab ou de traitements conventionnels

Author

Aldahmash, Abdulaziz, Cotten, Caroline, Hebert, Vivien, Gillibert, Andre, Duvert-Lehembre, Sophie, Debarbieux, Sebastien, Chosidow, Olivier, Dupin, Nicolas, Alexandre, Marina, Tancrede-Bohin, Emmanuelle, Picard-Dahan, Catherine, Gusdorf, Laurence, Lok, Catherine, Doutre, Marie-Sylvie, Konstantinou, Maria Polina, Chiaverini, Christine, Misery, Laurent, Dupuy, Alain, Quereux, Gaelle, Morice, Cecile, D’incan, Michel, Bedane, Christophe, Cordel, Nadege, Dereure, Olivier, Machet, Laurent, Audran, Martine Avenel, Richard-Lallemand, Marie-Aleth, Vabres, Pierre, Labeille, Bruno, Beneton, Nathalie, and Joly, Pascal

Published
2021
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37. Dermatomyositis and Immune-Mediated Necrotizing Myopathies: A Window on Autoimmunity and Cancer

Author

Aussy, Audrey, Boyer, Olivier, Cordel, Nadège, Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Service de Dermatologie et Médecine Interne [Pointe-à-Pitre, Guadeloupe], and CHU Pointe-à-Pitre/Abymes [Guadeloupe]

Subjects
[SDV]Life Sciences [q-bio], Immunology, autoimmunity, TIF1gamma, cancer, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.CAN]Life Sciences [q-bio]/Cancer, myositis, autoantibody, ComputingMilieux_MISCELLANEOUS
Abstract

Autoimmune myopathies (myositides) are strongly associated with malignancy. The link between myositis and cancer, originally noticed by Bohan and Peter in their classification in 1975 (1), has been evidenced by large population-based cohort studies and a recent meta-analysis. The numerous reports of cases in which the clinical course of myositis reflects that of cancer and the short delay between myositis and cancer onset support the notion that myositis may be an authentic paraneoplastic disorder. Thus, cancer-associated myositis raises the question of cancer as a cause rather than a consequence of autoimmunity. Among myositides, dermatomyositis and more recently, although to a lesser extent, immune-mediated necrotizing myopathies are the most documented forms associated with cancer. Interestingly, the current diagnostic approach for myositis is based on the identification of specific antibodies where each antibody determines specific clinical features and outcomes. Recent findings have shown that the autoantibodies anti-TIF1γ, anti-NXP2 and anti-HMGCR are associated with cancers in the course of myositis. Herein, we highlight the fact that the targets of these three autoantibodies involve cellular pathways that intervene in tumor promotion and we discuss the role of cancer mutations as autoimmunity triggers in adult myositis.

Published
2017

38. Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis

Author

Cordel, Nadège, Tressières, Benoît, D'Incan, Michel, Machet, Laurent, Grange, Florent, Estève, Eric, Dalac, Sophie, Ingen-Housz-Oro, Saskia, Bagot, Martine, Beylot-Barry, Marie, Joly, Pascal, Tressieres, B., DIncan, M., Esteve, E., Service de Dermatologie et Médecine Interne [Pointe-à-Pitre, Guadeloupe], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Physiopathologie, Autoimmunité, maladies Neuromusculaires et THErapies Régénératrices (PANTHER), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service de Dermatologie, Hôtel-Dieu, Service de dermatologie (CHRU de Tours), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Département de Dermatologie [CHU de Reims], Centre Hospitalier Universitaire de Reims (CHU Reims), Physiopathologie vasculaire : interactions cellulaires, signalisation et vieillissement, Université Joseph Fourier - Grenoble 1 (UJF)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital du Bocage, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), CHU Henri Mondor, Institut Mondor de recherche biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Bordeaux [Bordeaux], Service de dermatologie [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], CHU Henri Mondor [Créteil], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Skin Neoplasms, Lymphoma, Hematologic Malignancies, Lymphomatoid papulosis, [SDV]Life Sciences [q-bio], Kaplan-Meier Estimate, Gastroenterology, Disease-Free Survival, Cutaneous lymphoma, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, immune system diseases, Internal medicine, hemic and lymphatic diseases, medicine, Humans, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Odds ratio, Frequency, Middle Aged, Prognosis, medicine.disease, Confidence interval, humanities, 3. Good health, Oncology, Risk factors, 030220 oncology & carcinogenesis, Concomitant, Female, Lymphomas, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology
Abstract

Background Lymphomatoid papulosis (LyP) is classified as an indolent cutaneous lymphoma, but outcome dramatically worsens if LyP is associated with lymphoma. The frequency of this association remains unclear in the literature. Here, we assess the frequency and risk factors of association between LyP and another lymphoma in an 11-year retrospective study conducted in 8 dermatology departments belonging to the French Study Group on Cutaneous Lymphoma (FSGCL). Patients and methods Patients with LyP were identified and data extracted from the FSGCL registry between 1991 and 2006. Patients were followed up to January 2014. Age, sex, number of skin lesions, histologic subtype, and genotype were recorded at baseline. Risk factors were determined using univariate and multivariate analysis. Cumulative probability of association was calculated using the Kaplan-Meier method. Results We observed 52 cases of lymphomas (cutaneous, n = 38; systemic, n = 14) in 44 of 106 patients (41%). Lymphoma diagnosis was concomitant with or prior to LyP diagnosis in 31 cases and occurred during the course of LyP in 21 cases (cutaneous, n = 14; systemic, n = 7; median delay: 5 years; interquartile range: 1.5-7 years). In multivariate analysis, main prognostic factors for association between LyP and another lymphoma were older age (odds ratio [OR]: 1.05 per year; 95% confidence interval [CI]: 1.01-1.08; p = .011) and presence of a T-cell clone in LyP lesions (OR: 7.55; 95% CI: 2.18-26.18; p = .001). Conclusion Older age and presence of a T-cell clone in LyP lesions are risk factors for associated lymphomas in patients with LyP. These findings should help to identify patients who require close management in clinical practice. Implications for practice The management of lymphomatoid papulosis (LyP) is that of an indolent cutaneous lymphoma, based on its excellent prognosis. However, this good prognosis is altered if LyP is associated with lymphoma. Furthermore, risk factors for and frequency of this association remain unclear in the literature. The results presented here demonstrate a high rate of association between LyP and other lymphomas (41%) as well as a long median delay of occurrence (5 years), which emphasizes the need for prolonged follow-up of patients with LyP. Moreover, two main risk factors (i.e., older age and presence of a T-cell clone in LyP lesions) are highlighted, which should help clinical practitioners to identify patients who require close management.

Published
2016

39. Epidemiology and Characteristics of Kikuchi-Fujimoto Disease in the African-Descent Population of Martinique, French West Indies.

Author

Moinet, Florence, Molinié, Vincent, Béraud, Guillaume, Polomat, Katlyne, Cordel, Nadège, Sainte-Marie, Dominique, Duffas, Olivier, Duflo, Suzy, Bomahou, Charlène, Arfi, Serge, Deligny, Christophe, Molinié, Vincent, Béraud, Guillaume, Cordel, Nadège, and Bomahou, Charlène

Abstract

Objective: To provide an epidemiologic description of Kikuchi-Fujimoto disease (KFD), and to describe its relationship with systemic lupus erythematosus (SLE) in a population of sub-Saharan origin.Methods: Patients were retrospectively included on the basis of lymph node histology compatible with KFD reported in Martinique from 1991 until 2013. In order to describe the characteristics of the disease in a larger cohort, we subsequently included more patients of Afro-Caribbean origin from Guadeloupe and French Guiana.Results: In Martinique, mean annual incidence between 1991 and 2013 was 2.78 cases for 1 million inhabitants (95% confidence interval 1.73-3.93). A total of 36 Afro-Caribbean patients from the 3 French American regions were included. Mean age was 30.5 years (range 5-59 years) and the female:male ratio was 3:1. The main characteristics were cervical adenopathies (88.8%), fever (83.3%), asthenia (73.0%), weight loss (64.4%), and recurrence in 33.3%. KFD was associated with lupus (n = 9 for SLE, n = 2 for cutaneous lupus) in 36.6% (11 of 30).Conclusion: We report the first epidemiologic description of KFD in a population of sub-Saharan origin. According to our data, this disease is present in the black African diaspora and is strongly associated with autoimmune diseases, particularly lupus. [ABSTRACT FROM AUTHOR]

Published
2016
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41. Use of Anti-transcriptional Intermediary Factor-1 Gamma Autoantibody in Identifying Adult Dermatomyositis Patients with Cancer: A Systematic Review and Meta-analysis.

Author

BEST, Marion, MOLINARI, Nicolas, CHASSET, François, VINCENT, Thierry, CORDEL, Nadège, and BESSIS, Didier

Subjects
META-analysis, DERMATOMYOSITIS, CANCER patients
Abstract

Anti-transcriptional intermediary factor-1γ (TIF-1γ) autoantibody may be associated with cancer in adult patients with dermatomyositis. The aim of this study was to evaluate the risk of cancer in the presence of anti-TIF-1γ autoantibody in adult dermatomyositis. A comprehensive database search of EMBASE, MEDLINE and the Cochrane Library up to May 2018 was performed using the main key words "dermatomyositis", ""myositis", "inflammatory myopathies" and "anti- TIF-1". Eighteen studies, with a total of 1,962 dermatomyositides, were included in the meta-analysis. The pooled prevalence of cancer-associated dermatomyositis in patients with anti-TIF-1γ autoantibody was 0.41 (95% confidence interval (CI) 0.36-0.45). In the presence of anti-TIF-1γ autoantibody, the overall diagnostic odds ratio of cancer was 9.37 (95% CI 5.37-16.34) with low heterogeneity (Cochran's Q: 14.88 (df = 17, p = 0.604); I2 = 0%). The results of this systematic review confirm that detection of anti-TIF- 1γ autoantibody is a valuable tool to identify a subset of adult dermatomyositis patients with higher risk of cancer. [ABSTRACT FROM AUTHOR]

Published
2019
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42. Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients

Author

Thomas, Guillemette, primary, Cohen Aubart, Fleur, additional, Chiche, Laurent, additional, Haroche, Julien, additional, Hié, Miguel, additional, Hervier, Baptiste, additional, Costedoat-Chalumeau, Nathalie, additional, Mazodier, Karine, additional, Ebbo, Mikael, additional, Cluzel, Philippe, additional, Cordel, Nadège, additional, Ribes, David, additional, Chastre, Jean, additional, Schleinitz, Nicolas, additional, Veit, Véronique, additional, Piette, Jean-Charles, additional, Harlé, Jean-Robert, additional, Combes, Alain, additional, and Amoura, Zahir, additional

Published
2016
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45. Lupus Myocarditis: Initial Presentation and Longterm Outcomes in a Multicentric Series of 29 Patients.

Author

Thomas, Guillemette, Aubart, Fleur Cohen, Chiche, Laurent, Haroche, Julien, Hié, Miguel, Hervier, Baptiste, Costedoat-Chalumeau, Nathali, Mazodier, Karine, Ebbo, Mikael, Cluzel, Philippe, Cordel, Nadège, Ribes, David, Chastre, Jean, Schleinitz, Nicolas, Veit, Véronique, Piette, Jean-Charles, Harlé, Jean-Robert, Combes, Alain, and Amoura, Zahir

Published
2017
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47. A three-year-analysis of fixed drug eruptions in hospital settings in France

Author

Brahimi, Nesrine, additional, Routier, Emilie, additional, Raison-Peyron, Nadia, additional, Tronquoy, Anne-Fleur, additional, Pouget-Jasson, Caroline, additional, Amarger, Stéphanie, additional, Machet, Laurent, additional, Amsler, Emmanuelle, additional, Claeys, Antoine, additional, Sassolas, Bruno, additional, Leroy, Dominique, additional, Grange, Anne, additional, Dupuy, Alain, additional, Cordel, Nadège, additional, Bonnetblanc, Jean-Marie, additional, Milpied, Brigitte, additional, Doutre, Marie-Sylvie, additional, Guinnepain, Marie-Thérèse, additional, Barbaud, Annick, additional, Chosidow, Olivier, additional, Roujeau, Jean-Claude, additional, Lebrun-Vignes, Bénédicte, additional, and Descamps, Vincent, additional

Published
2010
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49. Neurological Disorders in Patients with Bullous Pemphigoid

Author

Cordel, Nadège, primary, Chosidow, Olivier, additional, Hellot, Marie-France, additional, Delaporte, Emmanuel, additional, Lok, Catherine, additional, Vaillant, Loïc, additional, Bernard, Philippe, additional, D’Incan, Michel, additional, Roujeau, Jean Claude, additional, and Joly, Pascal, additional

Published
2007
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50. Unresectable Perineal Cuniculatum Carcinoma: Partial Remission Using Systemic Isotretinoin and Interferon-α2a Therapy.

Author

Tauber, Marie, Monsel, Gentiane, Bonnecarrère, Lucie, Battistella, Maxime, Cordel, Nadège, Honein, Carla, Aubin, François, Bagot, Martine, Petit, Antoine, Lebbé, Céleste, and Viguier, Manuelle

Subjects
PERINEUM, HIV-positive persons, SKIN diseases, DERMATOLOGY, CANCER
Abstract

A case study describing perineal carcinoma cuniculatum (CC) complicating giant condyloma in an HIV-infected patient is presented. The patient was treated with combined systemic isotretinoin and interferon therapy when surgery, radiotherapy or chemotherapy could not be used. Topics covered include the medical history of the patient, the clinical presentation of CC, and the management and outcome of the patient.

Published
2014
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