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Candidate gene and genome-wide association studies (GWAS) have identified 15 independent genomic regions associated with bladder cancer risk. In search for additional susceptibility variants, we followed up on four promising single-nucleotide polymorphisms (SNPs) that had not achieved genome-wide significance in 6911 cases and 11 814 controls (rs6104690, rs4510656, rs5003154 and rs4907479, P < 1 × 10(-6)), using additional data from existing GWAS datasets and targeted genotyping for studies that did not have GWAS data. In a combined analysis, which included data on up to 15 058 cases and 286 270 controls, two SNPs achieved genome-wide statistical significance: rs6104690 in a gene desert at 20p12.2 (P = 2.19 × 10(-11)) and rs4907479 within the MCF2L gene at 13q34 (P = 3.3 × 10(-10)). Imputation and fine-mapping analyses were performed in these two regions for a subset of 5551 bladder cancer cases and 10 242 controls. Analyses at the 13q34 region suggest a single signal marked by rs4907479. In contrast, we detected two signals in the 20p12.2 region-the first signal is marked by rs6104690, and the second signal is marked by two moderately correlated SNPs (r(2) = 0.53), rs6108803 and the previously reported rs62185668. The second 20p12.2 signal is more strongly associated with the risk of muscle-invasive (T2-T4 stage) compared with non-muscle-invasive (Ta, T1 stage) bladder cancer (case-case P ≤ 0.02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer.

The photocatalyst composition affects the chemical–physical properties and directly impacts photocatalytic activity, both in the hydrogen production and degradation of organic contaminants. In this work, the influence of zeolitic structures NaA, NaY, and ZSM‐5 combined with a 10% active phase, TiO2 catalyst doped with 1% copper, and cobalt cocatalysts was tested to mineralize the reactive blue dye (CI250) and to produce hydrogen by photocatalysis under ultraviolet radiation. The band gap energy was affected mainly by the cocatalyst, while the Brunauer‐Emmett‐Teller method (BET) area was affected by the zeolite structure as well as the X‐ray diffraction (XRD). The most active catalyst was the Cu@TiO2/NaY, which promoted a hydrogen production rate of 240 μmolH2gcat−1 using 10% ethanol (v/v) aqueous solution as a sacrificial agent and mineralization of 53% of the organic dye, followed by the catalysts impregnated on ZSM‐5 zeolites, which had discolouration up to 50% and hydrogen evolution of 92.6 and 109.7 μmolH2gcat−1 for the catalyst doped with Cu and Co, respectively. [ABSTRACT FROM AUTHOR]

Describes problem-based thematic instruction in an effort to give both students and teachers meaningful experiences. (MG)

Describes fourth graders' observations and hypotheses about the sun and moon and how the three-dimensional reality gradually replaced the inadequate two-dimensional models of textbooks. Discusses implications for instruction of this progression from concrete to abstract. (HTH)

Describes an inservice program for which teachers watched the moon, kept a journal of its appearances, made drawings of it, and tried to fathom its habits. Asserts that through being involved with this learning experience, teachers understood more about how to teach productively. (SRT)

Analyzes writing samples of 22 first graders and 13 second graders to determine how children learn the rules of punctuation. Finds they develop necessary hypotheses which are alternative to the standard end-sentence period placement rule. Suggests young "language scientists" need opportunities to practice this innate trade: rule formation. (NH)