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16 results on '"Cordeiro, Marta Nascimento"'

1. Phoneutria nigriventer Venom and Toxins: A Review

Author

de Lima, Maria Elena, Figueiredo, Suely Gomes, Matavel, Alessandra, Nunes, Kenia Pedrosa, da Silva, Carolina Nunes, De Marco Almeida, Flávia, Diniz, Marcelo Ribeiro Vasconcelos, do Cordeiro, Marta Nascimento, Stankiewicz, Maria, Beirão, Paulo Sérgio Lacerda, Gopalakrishnakone, P., Editor-in-chief, Corzo, Gerardo A., editor, de Lima, Maria Elena, editor, and Diego-García, Elia, editor

Published
2016
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2. The spider toxin Phα1β recombinant possesses strong analgesic activity

Author

Rigo, Flavia Karine, Trevisan, Gabriela, De Prá, Samira Dal-Toé, Cordeiro, Marta Nascimento, Borges, Marcia Helena, Silva, Juliana Figueiredo, Santa Cecilia, Flavia Viana, de Souza, Alessandra Hubner, de Oliveira Adamante, Gabriela, Milioli, Alessandra Marcon, de Castro Junior, Célio José, Ferreira, Juliano, and Gomez, Marcus Vinicius

Published
2017
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3. Phoneutria nigriventer Venom and Toxins: A Review

Author

de Lima, Maria Elena, primary, Figueiredo, Suely Gomes, additional, Matavel, Alessandra, additional, Nunes, Kenia Pedrosa, additional, da Silva, Carolina Nunes, additional, de Marco Almeida, Flávia, additional, Diniz, Marcelo Ribeiro Vasconcelos, additional, do Cordeiro, Marta Nascimento, additional, Stankiewicz, Maria, additional, and Beirão, Paulo Sérgio Lacerda, additional

Published
2015
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4. PnPP-19, a Synthetic and Nontoxic Peptide Designed from a Phoneutria nigriventer Toxin, Potentiates Erectile Function via NO/cGMP

Author

Silva, Carolina Nunes, Nunes, Kenia Pedrosa, Torres, Fernanda Silva, Cassoli, Juliana Silva, Santos, Daniel Moreira, Almeida, Flávia De Marco, Matavel, Alessandra, Cruz, Jader Santos, Santos-Miranda, Arthur, Nunes, Allancer Divino C., Castro, Carlos Henrique, Machado de Ávila, Ricardo Andrés, Chávez-Olórtegui, Carlos, Láuar, Stephanie Stransky, Felicori, Liza, Resende, Jarbas Magalhães, Camargos, Elizabeth Ribeiro da Silva, Borges, Márcia Helena, Cordeiro, Marta Nascimento, Peigneur, Steve, Tytgat, Jan, and de Lima, Maria Elena

Published
2015
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6. An Evaluation of the Antinociceptive Effects of Phα1β, a Neurotoxin from the Spider Phoneutria nigriventer, and ω-Conotoxin MVIIA, a Cone Snail Conus magus Toxin, in Rat Model of Inflammatory and Neuropathic Pain

Author

de Souza, Alessandra Hubner, Castro, Jr., Célio J., Rigo, Flavia Karine, de Oliveira, Sara Marchesan, Gomez, Renato Santiago, Diniz, Danuza Montijo, Borges, Marcia Helena, Cordeiro, Marta Nascimento, Silva, Marco Aurélio Romano, Ferreira, Juliano, and Gomez, Marcus Vinicius

Published
2013
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8. Mechanisms Involved in the Nociception Triggered by the Venom of the Armed Spider Phoneutria nigriventer

Author

Gewehr, Camila, primary, Oliveira, Sara Marchesan, additional, Rossato, Mateus Fortes, additional, Trevisan, Gabriela, additional, Dalmolin, Gerusa Duarte, additional, Rigo, Flávia Karine, additional, de Castro Júnior, Célio José, additional, Cordeiro, Marta Nascimento, additional, Ferreira, Juliano, additional, and Gomez, Marcus V., additional

Published
2013
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9. PhTx3-4, a Spider Toxin Calcium Channel Blocker, Reduces NMDA-Induced Injury of the Retina.

Author

Binda, Nancy Scardua, Petruceli Carayon, Charles Porto, Agostini, Rafael Mourão, do Nascimento Pinheiro, Ana Cristina, Cordeiro, Marta Nascimento, Romano Silva, Marco Aurélio, Silva, Juliana Figueira, Rita Pereira, Elizete Maria, da Silva Junior, Claudio Antonio, de Castro Junior, Célio José, Sena Guimarães, Andre Luiz, and Gomez, Marcus Vinicius

Abstract

The in vivo neuroprotective effect of PhTx3-4, a spider toxin N-P/Q calcium channel blocker, was studied in a rat model of NMDA-induced injury of the retina. NMDA (N-Methyl-D-Aspartate)-induced retinal injury in rats reduced the b-wave amplitude by 62% 3.6%, indicating the severity of the insult. PhTx3-4 treatment increased the amplitude of the b-wave, which was almost equivalent to the control retinas that were not submitted to injury. The PhTx3-4 functional protection of the retinas recorded on the ERG also was observed in the neuroprotection of retinal cells. NMDA-induced injury reduced live cells in the retina layers and the highest reduction, 84%, was in the ganglion cell layer. Notably, PhTx3-4 treatment caused a remarkable reduction of dead cells in the retina layers, and the highest neuroprotective effect was in the ganglion cells layer. NMDA-induced cytotoxicity of the retina increased the release of glutamate, reactive oxygen species (ROS) production and oxidative stress. PhTx3-4 treatment reduced glutamate release, ROS production and oxidative stress measured by malondialdehyde. Thus, we presented for the first time evidence of in vivo neuroprotection from NMDA-induced retinal injury by PhTx3-4 (-ctenitoxin-Pn3a), a spider toxin that blocks N-P/Q calcium channels. [ABSTRACT FROM AUTHOR]

Published
2016
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10. An Evaluation of the Antinociceptive Effects of Phα1β, a Neurotoxin from the Spider Phoneutria nigriventer, and ω-Conotoxin MVIIA, a Cone Snail Conus magus Toxin, in Rat Model of Inflammatory and Neuropathic Pain

Author

de Souza, Alessandra Hubner, primary, Castro, Célio J., additional, Rigo, Flavia Karine, additional, de Oliveira, Sara Marchesan, additional, Gomez, Renato Santiago, additional, Diniz, Danuza Montijo, additional, Borges, Marcia Helena, additional, Cordeiro, Marta Nascimento, additional, Silva, Marco Aurélio Romano, additional, Ferreira, Juliano, additional, and Gomez, Marcus Vinicius, additional

Published
2012
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16. Phoneutria nigriventertoxins block tityustoxininduced calcium influx in synaptosomes

Author

Miranda, Debora Marques, Romano-Silva, Marco Aurélio, Kalapothakis, Evanguedes, Diniz, Carlos Ribeiro, Cordeiro, Marta Nascimento, Santos, Tasso Moraes, Antonio, Marco, Prado, Máximo, and Gomez, Marcus Vinicius

Abstract

NEUROTOXINS can help the understanding of mechanisms involved in neurotransmission. We here report that two neurotoxin isoforms, Tx3-3 and Tx3-4 obtained from the venom of the spider Phoneutria nigriventerinhibited the 45 Ca2influx in rat cortical synaptosomes induced by the scorpion venom tityustoxin. The IC50for Tx3-3 and Tx3-4 were 0.32 and 7.9 nM, respectively. The neurotoxins Tx3-3 and Tx3-4 are very effective in inhibiting 45 Ca2influx and they should be useful in studies involving Ca2-dependent processes.

Published
1998

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