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331 results on '"Corbishley, C."'

1. Tumor evolution metrics predict recurrence beyond 10 years in locally advanced prostate cancer

Author

Fernandez-Mateos, J, Cresswell, G, Trahearn, N, Webb, K, Sakr, C, Lampis, A, Stuttle, C, Corbishley, C, Stavrinides, V, Zapata, L, Spiteri, I, Heide, T, Gallagher, L, James, C, Ramazzotti, D, Gao, A, Kote-Jarai, Z, Acar, A, Truelove, L, Proszek, P, Murray, J, Reid, A, Wilkins, A, Hubank, M, Eeles, R, Dearnaley, D, Sottoriva, A, Fernandez-Mateos, Javier, Cresswell, George D., Trahearn, Nicholas, Webb, Katharine, Sakr, Chirine, Lampis, Andrea, Stuttle, Christine, Corbishley, Catherine M., Stavrinides, Vasilis, Zapata, Luis, Spiteri, Inmaculada, Heide, Timon, Gallagher, Lewis, James, Chela, Ramazzotti, Daniele, Gao, Annie, Kote-Jarai, Zsofia, Acar, Ahmet, Truelove, Lesley, Proszek, Paula, Murray, Julia, Reid, Alison, Wilkins, Anna, Hubank, Michael, Eeles, Ros, Dearnaley, David, Sottoriva, Andrea, Fernandez-Mateos, J, Cresswell, G, Trahearn, N, Webb, K, Sakr, C, Lampis, A, Stuttle, C, Corbishley, C, Stavrinides, V, Zapata, L, Spiteri, I, Heide, T, Gallagher, L, James, C, Ramazzotti, D, Gao, A, Kote-Jarai, Z, Acar, A, Truelove, L, Proszek, P, Murray, J, Reid, A, Wilkins, A, Hubank, M, Eeles, R, Dearnaley, D, Sottoriva, A, Fernandez-Mateos, Javier, Cresswell, George D., Trahearn, Nicholas, Webb, Katharine, Sakr, Chirine, Lampis, Andrea, Stuttle, Christine, Corbishley, Catherine M., Stavrinides, Vasilis, Zapata, Luis, Spiteri, Inmaculada, Heide, Timon, Gallagher, Lewis, James, Chela, Ramazzotti, Daniele, Gao, Annie, Kote-Jarai, Zsofia, Acar, Ahmet, Truelove, Lesley, Proszek, Paula, Murray, Julia, Reid, Alison, Wilkins, Anna, Hubank, Michael, Eeles, Ros, Dearnaley, David, and Sottoriva, Andrea

Abstract

Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measurements in controlled clinical trials. We mapped genomic intratumor heterogeneity in locally advanced prostate cancer using 642 samples from 114 individuals enrolled in clinical trials with a 12-year median follow-up. We concomitantly assessed morphological heterogeneity using deep learning in 1,923 histological sections from 250 individuals. Genetic and morphological (Gleason) diversity were independent predictors of recurrence (hazard ratio (HR) = 3.12 and 95% confidence interval (95% CI) = 1.34-7.3; HR = 2.24 and 95% CI = 1.28-3.92). Combined, they identified a group with half the median time to recurrence. Spatial segregation of clones was also an independent marker of recurrence (HR = 2.3 and 95% CI = 1.11-4.8). We identified copy number changes associated with Gleason grade and found that chromosome 6p loss correlated with reduced immune infiltration. Matched profiling of relapse, decades after diagnosis, confirmed that genomic instability is a driving force in prostate cancer progression. This study shows that combining genomics with artificial intelligence-aided histopathology leads to the identification of clinical biomarkers of evolution.

Published
2024

19. Diagnosis

Author

Zhukhovitski, W. G., Aruin, L. I., Ilchenko, A. S., Gorodinskaya, V. S., Meyer-Rosberg, K., Gustavsson, S., Maeland, J. A., Kleveland, P. M., Kvam, A. I., Witteman, E. M., Bloembergen, P., Koning, R. W. de, Alcalde, M., Lanche, A., Carpintero, P., Garcia, R., Sanchez, P., Pajares, J. M., Tham, T. C. K., McLaughlin, N., Hughes, D. F., Ferguson, M., Crosbie, J. J., Madden, M., Namnyak, S., O’Connor, F. A., Gosciniak, G., Matysiak-Budnik, T., Poniewierka, E., Przondo-Mordarska, A., Monno, R., Quarto, M., Ierardi, E., Chironna, M., Cafforio, P., Margiotta, M., Francavilla, A., Yamamoto, I., Fukuda, Y., Tonokatsu, Y., Takami, S., Mizuta, T., Hayashi, T., Tamura, T., Hori, S., Shimoyama, T., Juutinen, K., Granberg, C., Häivä, V. M., Lehtonen, O. P., Kujari, H., Mansikka, A., Martín, E., Sanz, J. C., Alarcón, T., Cardenoso, L., López-Brea, M., Powell, Frank C., Daw, M. A., Duguid, Chris, Goossens, H., Glupczynski, Y., Burette, A., Deprez, C., Borre, C. Van den, Butzler, J. P., Veenendaa, R. A., Peña, A. S., Kuiper, I., Duijn, W. Van, Lamers, C. B. H. W., De Koster, E., Fannes, F., Denis, P., Baise, E., Van Roosbroeck, A., Nyst, J. F., Deltenre, M., Adeyemi, E. O., Al-Homsi, M., Goodwin, C. S., Demers, B., Karmali, M., Sherman, P., Pender, S. M., Courtney, M. G., Holloway, H., Sexton, T. B., Fielding, J. F., Mendes, E. N., Queiroz, D. M. M., Rocha, G. A., Moura, S. B., Barbosa, M. I., Carvalhaes, S. M., Freitas, M. L. P., Mendall, M. A., Goggin, P. M., Molineaux, N., Levi, J., Harding, T., Maneno, J. H., Corbishley, C., Finlayson, C., Badue, S., Northfield, T. C., Moldrzyyk, Veltzhe-Schliehenlr, Vogt, H., Trautman, K., Hampel, M., Hausmann, T., Gratz, K. F., Kelber, A., Soudan, B., Wagner, S., Hundeshagen, H., Jurgos, L., Druguet, M., Pommier, C., Rousseau, M., Courpron, P., Brazier, J. L., Marks, J., Rao, G. Gopal, Cobden, I., Johri, R., John, S., Rodgers, A. D., Awad, Magbri, Naqvi, Altaf, McCarthy, C. F., Kristiansen, Jette E., Andersen, L. P., Justesen, T., Hvidberg, E. F., Tahar, A. S., Reid, J., Boothmann, P., Gemmell, C. G., Lee, F. D., Sturrock, R. D., Russell, I., Tessaro, P., Schiavon, R., Contini, M. G., Rugge, M., Guido, M., Glorioso, S., Turatello, F., Naccarato, R., Kist, M., Eschweiler, B., Koch, H. K., Dzierzanowska, D., Vogtt, E., Wojda, U., Muszynski, J., Laszewicz, W., and Skawinski, W.

Published
1992
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31. Angiomyolipomata: challenges, solutions, and future prospects based on over 100 cases treated

Author

Sooriakumaran, P, Gibbs, P, Coughlin, G, Attard, V, Elmslie, F, Kingswood, C, Taylor, J, Corbishley, C, Patel, U, and Anderson, C

Abstract

OBJECTIVE: To examine the presentation, management and outcomes of patients with renal angiomyolipoma (AML) over a period of 10 years, at St George's Hospital, London, UK. PATIENTS AND METHODS: We assessed retrospectively 102 patients (median follow-up 4 years) at our centre; 70 had tuberous sclerosis complex (TSC; median tumour size 3.5 cm) and the other 32 were sporadic (median tumour size 1.2 cm). Data were gathered from several sources, including radiology and clinical genetics databases. The 77 patients with stable disease were followed up with surveillance imaging, and 25 received interventions, some more than one. Indications for intervention included spontaneous life-threatening haemorrhage, large AML (10-20 cm), pain and visceral compressive symptoms. RESULTS: Selective arterial embolization (SAE) was performed in 19 patients; 10 received operative management and four had a radiofrequency ablation (RFA). SAE was effective in controlling haemorrhage from AMLs in the acute setting (six) but some patients required further intervention (four) and there was a significant complication rate. The reduction in tumour volume was only modest (28%). No complications occurred after surgery (median follow-up 5.5 years) or RFA (median follow-up 9 months). One patient was entered into a trial and treated with sirolimus (rapamycin). CONCLUSIONS: The management of AML is both complex and challenging, especially in those with TSC, where tumours are usually larger and multiple. Although SAE was effective at controlling haemorrhage in the acute setting it was deemed to be of limited value in the longer term management of these tumours. Thus novel techniques such as focused ablation and pharmacological therapies including the use of anti-angiogenic molecules and mTOR inhibitors, which might prove to be safer and equally effective, should be further explored.

Published
2016

32. Malignant epithelial tumours of the penis

Author

Cubilla, A L, Amin, M B, Ayala, A, Ayala, G, Chaux, A, Corbishley, C, Dillner, J, Moch, H, Sanchez, D F, Soares, F A, Tamboli, P, Young, R H, University of Zurich, Moch, H, Humphrey, P A, Ulbright, T M, and Reuter, V E

Subjects
10049 Institute of Pathology and Molecular Pathology, 610 Medicine & health
Published
2016

38. Malignant epithelial tumours of the penis

Author

Moch, H, Humphrey, P A, Ulbright, T M, Reuter, V E, Moch, H ( H ), Humphrey, P A ( P A ), Ulbright, T M ( T M ), Reuter, V E ( V E ), Cubilla, A L, Amin, M B, Ayala, A, Ayala, G, Chaux, A, Corbishley, C, Dillner, J, Sanchez, D F, Soares, F A, Tamboli, P, Young, R H, Moch, H, Humphrey, P A, Ulbright, T M, Reuter, V E, Moch, H ( H ), Humphrey, P A ( P A ), Ulbright, T M ( T M ), Reuter, V E ( V E ), Cubilla, A L, Amin, M B, Ayala, A, Ayala, G, Chaux, A, Corbishley, C, Dillner, J, Sanchez, D F, Soares, F A, Tamboli, P, and Young, R H

Published
2016

47. Erratum: Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Author

Cooper, CS, Eeles, R, Wedge, DC, Van Loo, P, Gundem, G, Alexandrov, LB, Kremeyer, B, Butler, A, Lynch, AG, Camacho, N, Massie, CE, Kay, J, Luxton, HJ, Edwards, S, Kote-Jarai, Z, Dennis, N, Merson, S, Leongamornlert, D, Zamora, J, Corbishley, C, Thomas, S, Nik-Zainal, S, Ramakrishna, M, O'Meara, S, Matthews, L, Clark, J, Hurst, R, Mithen, R, Bristow, RG, Boutros, PC, Fraser, M, Cooke, S, Raine, K, Jones, D, Menzies, A, Stebbings, L, Hinton, J, Teague, J, McLaren, S, Mudie, L, Hardy, C, Anderson, E, Joseph, O, Goody, V, Robinson, B, Maddison, M, Gamble, S, Greenman, C, Berney, D, Hazell, S, Livni, N, ICGC Prostate Group, Fisher, C, Ogden, C, Kumar, P, Thompson, A, Woodhouse, C, Nicol, D, Mayer, E, Dudderidge, T, Shah, NC, Gnanapragasam, V, Voet, T, Campbell, P, Futreal, A, Easton, D, Warren, AY, Foster, CS, Stratton, MR, Whitaker, HC, McDermott, U, Brewer, DS, and Neal, DE

Subjects
Genetics, Prostate cancer, medicine.anatomical_structure, Phylogenetics, Prostate, ICGC Prostate Group, medicine, 11 Medical And Health Sciences, 06 Biological Sciences, Biology, medicine.disease, Developmental Biology
Published
2015

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