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1. Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease

Author

Castañer, Olga, Pintó, Xavier, Subirana, Isaac, Amor, Antonio J., Ros, Emilio, Hernáez, Álvaro, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Estruch, Ramón, Lapetra, José, Gómez-Gracia, Enrique, Alonso-Gomez, Angel M., Fiol, Miquel, Serra-Majem, Lluís, Corbella, Emili, Benaiges, David, Sorli, Jose V., Ruiz-Canela, Miguel, Babió, Nancy, Sierra, Lucas Tojal, Ortega, Emilio, and Fitó, Montserrat

Published
2020
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2. Influence of lifestyle factors and staple foods from the Mediterranean diet on non-alcoholic fatty liver disease among older individuals with metabolic syndrome features

Author

Bullón-Vela, Vanessa, Abete, Itziar, Tur, Josep A., Pintó, Xavier, Corbella, Emili, Martínez-González, Miguel A., Toledo, Estefanía, Corella, Dolores, Macías, Manuel, Tinahones, Francisco, Fitó, Montserrat, Estruch, Ramon, Ros, Emilio, Salas-Salvadó, Jordi, Daimiel, Lidia, Zulet, M. Angeles, and Martínez, J. Alfredo

Published
2020
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3. The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial

Author

Candás-Estébanez, Beatriz, primary, Fernández-Cidón, Bárbara, additional, Corbella, Emili, additional, Tebé, Cristian, additional, Fanlo-Maresma, Marta, additional, Esteve-Luque, Virginia, additional, Salas-Salvadó, Jordi, additional, Fitó, Montserrat, additional, Riera-Mestre, Antoni, additional, Ros, Emilio, additional, and Pintó, Xavier, additional

Published
2024
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5. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author

Paz-Graniel, Indira, Babio, Nancy, Serra-Majem, Luís, Vioque, Jesús, Zomeño, Maria Dolores, Corella, Dolores, Díaz-López, Andrés, Pintó, Xavier, Bueno-Cavanillas, Aurora, Tur, Josep A., Daimiel, Lidia, Martínez, J. Alfredo, Becerra-Tomás, Nerea, Navarrete-Muñoz, Eva Mª, Schröder, Helmut, Fernández-Carrión, Rebeca, Ortiz-Andrellucchi, Adriana, Corbella, Emili, Riquelme-Gallego, Blanca, Gallardo-Alfaro, Laura, Micó, Víctor, Zulet, Marian, Barrubés, Laura, Fitó, Montserrat, Ruiz-Canela, Miguel, and Salas-Salvadó, Jordi

Published
2020
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7. Associations between self-reported periodontal disease, assessed using a very short questionnaire, cardiovascular disease events and all-cause mortality in a contemporary multi-ethnic population: The Multi-Ethnic Study of Atherosclerosis (MESA)

Author

Gonzalez-Navarro, Beatriz, Pintó-Sala, Xavier, Corbella, Emili, Jané-Salas, Enric, Miedema, Michael D., Yeboah, Joseph, Shea, Steve, Nasir, Khurram, Comin-Colet, Josep, Corbella, Xavier, Lopez-López, Jose, Blumenthal, Roger S., Blaha, Michael J., and Cainzos-Achirica, Miguel

Published
2018
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8. THE IMPACT OF THE MEDITERRANEAN DIET AND LIFESTYLE INTERVENTION ON LIPOPROTEIN SUB-CLASS PROFILES AMONG METABOLIC SYNDROME PATIENTS. FINDINGS OF A RANDOMIZED CONTROLLED TRIAL

Author

Candás-Estébanez, Beatriz, primary, Fernández-Cidón, Bárbara, additional, Corbella, Emili, additional, Tebé, Cristian, additional, Fanlo-Maresma, Marta, additional, Esteve-Luque, Virginia, additional, Salas-Salvadó, Jordi, additional, Fitó, Montse, additional, Riera-Mestre, Antoni, additional, Ros, Emilio, additional, and Pintó, Xavier, additional

Published
2023
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13. Differences in the diabetogenic effect of statins in patients with prediabetes. The PRELIPID study

Author

Trias, Ferran, primary, Pintó, Xavier, additional, Corbella, Emili, additional, Suárez-Tembra, Manuel, additional, Ruíz-García, Antonio, additional, Díaz-Díaz, José Luis, additional, Sánchez-Ruíz-Granado, Elena, additional, Sarasa, Itziar, additional, Martínez-Porqueras, Raul, additional, Rodríguez-Sánchez, Maria Angeles, additional, and Corbella, Xavier, additional

Published
2022
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16. Are Peripheral Biomarkers Determinants of Eating Styles in Childhood and Adolescence Obesity? A Cross-Sectional Study

Author

Desdentado, Lorena, primary, Navarrete, Jaime, additional, Folgado-Alufre, María, additional, de Blas, Ana, additional, Navarro-Siurana, Jéssica, additional, Ponce, Francisco, additional, Molinari, Guadalupe, additional, Jimeno-Martínez, Andrea, additional, Rupérez, Azahara I., additional, Bueno-Lozano, Gloria, additional, Cuenca-Royo, Aida, additional, Corbella, Emili, additional, Agüera, Zaida, additional, Baños, Rosa M., additional, and Álvarez-Pitti, Julio, additional

Published
2022
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18. Asymptomatic Carotid Atherosclerosis Cardiovascular Risk Factors and Common Hypertriglyceridemia Genetic Variants in Patients with Systemic Erythematosus Lupus

Author

Fanlo-Maresma, Marta, primary, Candás-Estébanez, Beatriz, additional, Esteve-Luque, Virginia, additional, Padró-Miquel, Ariadna, additional, Escrihuela-Vidal, Francesc, additional, Carratini-Moraes, Monica, additional, Corbella, Emili, additional, Corbella, Xavier, additional, and Pintó, Xavier, additional

Published
2021
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19. Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study

Author

Fernández-Cidón, Bárbara, primary, Candás-Estébanez, Beatriz, additional, Gil-Serret, Miriam, additional, Amigó, Núria, additional, Corbella, Emili, additional, Rodríguez-Sánchez, M. Ángeles, additional, Padró-Miquel, Ariadna, additional, Brotons, Carlos, additional, Hernández-Mijares, Antonio, additional, Calmarza, Pilar, additional, Jarauta, Estibaliz, additional, Brea, Angel J., additional, Mauri, Marta, additional, Guijarro, Carlos, additional, Vila, Àlex, additional, Valdivielso, Pedro, additional, Corbella, Xavier, additional, and Pintó, Xavier, additional

Published
2021
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20. Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications

Author

Bullon-Vela, Vanessa, Abete, Itziar, Tur, Josep A., Konieczna, Jadwiga, Romaguera, Dora, Pinto, Xavier, Corbella, Emili, Martinez-Gonzalez, Miguel A., Sayon-Orea, Carmen, Toledo, Estefania, Corella, Dolores, Macias-Gonzalez, Manuel, Tinahones, Francisco J., Fito, Montserrat, Estruch, Ramon, Ros, Emilio, Salas-Salvado, Jordi, Daimiel, Lidia, Mascaro, Catalina M., Angeles Zulet, Maria, Alfredo Martinez, Jose, and PREDIMED-Plus Investigators

Subjects
medicine.medical_specialty, Síndrome metabòlica, Endocrinology, Diabetes and Metabolism, Adipose tissue, 030209 endocrinology & metabolism, Systemic inflammation, lcsh:Diseases of the endocrine glands. Clinical endocrinology, metabolic syndrome, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, triglyceride glucose index, Internal medicine, insulin resistance, Medicine, visceral adipose tissue, Liver diseases, Original Research, lcsh:RC648-665, business.industry, Malalties del fetge, Cardiovascular Disease and Diabetes: Risk Factors, Prevention and Management, non-alcoholic fatty liver disease, medicine.disease, Metabolic syndrome, Endocrinology, 030211 gastroenterology & hepatology, medicine.symptom, Resistència a la insulina, business, Metabolic profile
Abstract

Background: Visceral adipose tissue (VAT) has a hazardous influence on systemic inflammation, insulin resistance and an adverse metabolic profile, which increases the risk of developing non-alcoholic fatty liver disease (NAFLD) and chronic complications of diabetes. In our study we aimed to evaluate the association of VAT and the triglyceride glucose (TyG) as a proxy of insulin resistance surrogated with metabolic and liver risk factors among subjects diagnosed with metabolic syndrome (MetS). Methods: A cross-sectional study was performed including 326 participants with MetS (55-75 years) from the PREDIMED-Plus study. Liver-status markers, VAT and TyG were assessed. Participants were stratified by tertiles according to VAT (n = 254) and TyG (n = 326). A receiver operating characteristic curve was used to analyse the efficiency of TyG for VAT. Results: Subjects with greater visceral fat depots showed worse lipid profile, higher homeostatic model assessment for insulin resistance (HOMA-IR), TyG, alanine transaminase (ALT), fibroblast growth factor-21 (FGF-21), fatty liver index (FLI) and hepatic steatosis index (HSI) compared with participants in the first tertile. The multi-adjusted linear-regression analyses indicated that individuals in the third tertile of TyG (>9.1-10.7) had a positive association with HOMA-IR [beta = 3.07 (95% confidence interval (CI) 2.28-3.86; p trend < 0.001)], ALT [beta = 7.43 (95% CI 2.23-12.63; p trend = 0.005)], gamma glutamyl transferase (GGT) [beta = 14.12 (95% CI 3.64-24.61; p trend = 0.008)], FGF-21 [beta = 190.69 (95% CI 93.13-288.25; p trend < 0.001)], FLI [beta = 18.65 (95% CI 14.97-22.23; p trend < 0.001)] and HSI [beta = 3.46 (95% CI, 2.23-4.68; p trend < 0.001)] versus participants from the first tertile. Interestingly, the TyG showed the largest area under the receiver operating curve (AUC) for women (AUC = 0.713; 95% CI 0.62-0.79) compared with men (AUC = 0.570; 95% CI 0.48-0.66). Conclusions: A disrupted VAT enlargement and impairment of TyG are strongly associated with liver status and cardiometabolic risk factors linked with NAFLD in individuals diagnosed with MetS. Moreover, the TyG could be used as a suitable and reliable marker estimator of VAT., The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: the PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014-2019; agreement #340918; granted to Dr MartinezGonzalez); the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigacion para la Salud (FIS) that is co-funded by the European Regional Development Fund (coordinated FIS projects led by Drs Salas-Salvado and Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332) and the Especial Action Project 'Implementacion y evaluacion de una intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus' (Dr Salas-Salvado); the Recercaixa (grant number 2013ACUP00194) (Dr Salas-Salvado); J. Salas-Salvado, gratefully acknowledges the financial suuport by ICREA under the ICREA Academia program; the SEMERGEN grant; International Nut and Dried Fruit Council-FESNAD (Long-term effects of an energy-restricted Mediterranean diet on mortality and cardiovascular disease 2014-015; no. 201302; Dr Martinez-Gonzalez); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (Dr Romaguera); grants from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant; grant of support to research groups 35/2011 (Balearic Islands Gov; FEDER funds; Drs Tur and Bouz). JK is contracted for the `FOLIUM' programme within the FUTURMed project. Talent for the medicine within the future from the Fundacion Instituto de Investigacion Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Programme 2014-2020 of the Balearic Islands). CMM received an FPU grant from the Ministry of Education, Spain. VB-V received a grant from the Centre for Nutrition Research of the University of Navarra.

Published
2020

21. Factores de riesgo asociados diferencialmente a la enfermedad de hígado graso no alcohólico en hombres y mujeres con síndrome metabólico

Author

Bullón Vela, María Vanessa, Abete, Itziar, Zulet, M. Angeles, Tur, J. Antoni, Pinto, Xavier, Corbella, Emili, Martínez-González, Miguel A., Corella, Dolores, Macías-González, Manuel, Tinahones Madueño, Francisco José, Fitó Colomer, Montserrat, Estruch, Ramón, Ros, Emilio, Salas-Salvadó, Jordi, Daimiel, Lidia, and Martínez, José Alfredo

Subjects
Obesidad abdominal, Síndrome metabólico, Grasa visceral, Sexo, Hígado graso no alcohólico
Abstract

Introducción: el hígado graso no alcohólico (HGNA) es una enfermedad hepática crónica más prevalente en los países occidentales. Objetivos: evaluar factores de riesgo asociados a HGNA en hombres y mujeres diagnosticados con SM estratificados según terciles del índice de esteatosis hepática (HSI). Métodos: análisis transversal del estudio PREDIMED Plus (incluyendo únicamente información del nodo Navarra-Nutrición). Un total de 278 participantes (141 hombres y 137 mujeres) con SM fueron estratificados según terciles de HSI. El estudio analizó variables clínicas, bioquímicas e información sobre el estilo de vida, como grado de adherencia a la dieta mediterránea y práctica de actividad física. Resultados: el análisis multivariante reveló que las mujeres tienen 4,54 unidades más de HSI (95% IC: 3,41 a 5,68) respecto a los hombres. Ambos sexos mostraron un incremento en los niveles de triglicéridos, TG/colesterol HDL e índice triglicéridos-glucosa (TyG) entre los terciles de HSI. Asimismo, se observó una asociación negativa entre la actividad física y el HSI (hombres: r = -0,19, p = 0,025; mujeres: r = -0,18, p = 0,031). La grasa visceral mostró una asociación positiva con el HSI en ambos sexos (hombres: r = 0,64, p < 0,001; mujeres: r = 0,46, p < 0,001). La adherencia a la dieta mediterránea es menor en los pacientes con HSI más elevado (hombres r = -0,18, p = 0,032; mujeres r = -0,19, p = 0,027). Conclusiones: las mujeres presentan mayor riesgo de daño hepático y se sugieren importantes diferencias de sexo en relación a la EHGNA. La adherencia a la dieta mediterránea y la actividad física se reafirman como factores clave frente a la regulación de enfermedades cardiovasculares entre las que se encuentra la EHGNA. El riesgo de esteatosis hepática en población adulta obesa y con SM disminuye. Los autores expresan su agradecimiento al Departamento de Salud del Gobierno de Navarra (61/2015), a la Fundació La Marató de TV (Ref. 201630.10) y al Instituto Carlos III (ISCIII) a través del Fondo de Investigación para la Salud (FIS, PI14/01919 y PI17/00926), cofinanciado por el Fondo Europeo de Desarrollo Regional (FEDER), CIBER Fisiopatología de la Obesidad y Nutrición (CIBERohn) y el Consejo Europeo de Investigación (Advanced Research Grant 2014-2019; agreement #340918 granted to MAM-G) por el soporte económico recibido. VBV tiene una beca del Centro de investigación en Nutrición de la Universidad de Navarra.

Published
2020

22. Factores de riesgo asociados difeencialmente a la enfermedad de hígado graso no alcohólico en hombres y mujeres con síndrome metabólico

Author

Bullón Vela, Vanessa, Abete, Itziar, Zulet, M. Angeles, Tur, Josep Antoni, Pintó Sala, Xavier, Corbella, Emili, Martínez González, Miguel A., Corella Piquer, Dolores, Macías González, Manuel, Tinahones, Francisco J., Fitó Colomer, Montserrat, Estruch Riba, Ramon, Ros Rahola, Emilio, Salas Salvadó, Jordi, Daimiel, Lidia, Martínez, J. Alfredo, and PREDIMED-Plus investigators

Subjects
Síndrome metabòlica, Obesitat, Alcoholic liver diseases, Obesity, Metabolic syndrome, Hepatopaties alcohòliques
Abstract

Introducción: el hígado graso no alcohólico (HGNA) es una enfermedad hepática crónica más prevalente en los países occidentales. Objetivos: evaluar factores de riesgo asociados a HGNA en hombres y mujeres diagnosticados con SM estratificados según terciles del índice de esteatosis hepática (HSI). Métodos: análisis transversal del estudio PREDIMED Plus (incluyendo únicamente información del nodo Navarra-Nutrición). Un total de 278 participantes (141 hombres y 137 mujeres) con SM fueron estratificados según terciles de HSI. El estudio analizó variables clínicas, bioquímicas e información sobre el estilo de vida, como grado de adherencia a la dieta mediterránea y práctica de actividad física. Resultados: el análisis multivariante reveló que las mujeres tienen 4,54 unidades más de HSI (95% IC: 3,41 a 5,68) respecto a los hombres. Ambos sexos mostraron un incremento en los niveles de triglicéridos, TG/colesterol HDL e índice triglicéridos-glucosa (TyG) entre los terciles de HSI. Asimismo, se observó una asociación negativa entre la actividad física y el HSI (hombres: r = -0,19, p = 0,025; mujeres: r = -0,18, p = 0,031). La grasa visceral mostró una asociación positiva con el HSI en ambos sexos (hombres: r = 0,64, p < 0,001; mujeres: r = 0,46, p < 0,001). La adherencia a la dieta mediterránea es menor en los pacientes con HSI más elevado (hombres r = -0,18, p = 0,032; mujeres r = -0,19, p = 0,027). Conclusiones: las mujeres presentan mayor riesgo de daño hepático y se sugieren importantes diferencias de sexo en relación al HGNA. La adherencia a la dieta mediterránea y la actividad física se reafirman como factores clave frente a la regulación de enfermedades cardiovasculares entre las que se encuentra el HGNA. El riesgo de esteatosis hepática en población adulta obesa y con SM disminuye.

Published
2020

23. Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial

Author

European Research Council, European Commission, Instituto de Salud Carlos III, Junta de Andalucía, Generalitat Valenciana, Martínez-González, Miguel Ángel, Fernandez-Lazaro, Cesar I., Toledo, Estefanía, Díaz-López, Andrés, Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Portolés, Olga, Soria-Florido, María, Konieczna, Jadwiga, Navarrete-Muñoz, Eva M., Tojal-Sierra, Lucas, Fernandez-Garcia, José Carlos, Abete, Itziar, Henríquez-Sánchez, Patricia, Muñoz-Garach, Araceli, Santos-Lozano, José Manuel, Corbella, Emili, Bibiloni, Maria del Mar, Becerra-Tomás, Nerea, Barragán, Rocío, Castañer, Olga, Fiol, Miquel, Hera, Manoli García de la, Belló-Mora, María C., Gea, Alfredo, Babio, Nancy, Fitó, Montserrat, Ruiz-Canela, Miguel, Zazpe, Itziar, Salas-Salvadó, Jordi, European Research Council, European Commission, Instituto de Salud Carlos III, Junta de Andalucía, Generalitat Valenciana, Martínez-González, Miguel Ángel, Fernandez-Lazaro, Cesar I., Toledo, Estefanía, Díaz-López, Andrés, Corella, Dolores, Goday, Albert, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, J. Alfredo, Serra-Majem, Luís, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Cano-Ibáñez, Naomi, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Buil-Cosiales, Pilar, Portolés, Olga, Soria-Florido, María, Konieczna, Jadwiga, Navarrete-Muñoz, Eva M., Tojal-Sierra, Lucas, Fernandez-Garcia, José Carlos, Abete, Itziar, Henríquez-Sánchez, Patricia, Muñoz-Garach, Araceli, Santos-Lozano, José Manuel, Corbella, Emili, Bibiloni, Maria del Mar, Becerra-Tomás, Nerea, Barragán, Rocío, Castañer, Olga, Fiol, Miquel, Hera, Manoli García de la, Belló-Mora, María C., Gea, Alfredo, Babio, Nancy, Fitó, Montserrat, Ruiz-Canela, Miguel, Zazpe, Itziar, and Salas-Salvadó, Jordi

Abstract

[Background]: Overall quality of dietary carbohydrate intake rather than total carbohydrate intake may determine the risk of cardiovascular disease (CVD)., [Objective]: We examined 6- and 12-mo changes in carbohydrate quality index (CQI) and concurrent changes in several CVD risk factors in a multicenter, randomized, primary-prevention trial (PREDIMED-Plus) based on an intensive weight-loss lifestyle intervention program., [Methods]: Prospective analysis of 5373 overweight/obese Spanish adults (aged 55–75 y) with metabolic syndrome (MetS). Dietary intake information obtained from a validated 143-item semiquantitative food-frequency questionnaire was used to calculate 6- and 12-mo changes in CQI (categorized in quintiles), based on 4 criteria (total dietary fiber intake, glycemic index, whole grain/total grain ratio, and solid carbohydrate/total carbohydrate ratio). The outcomes were changes in intermediate markers of CVD., [Results]: During the 12-mo follow-up, the majority of participants improved their CQI by increasing their consumption of fruits, vegetables, legumes, fish, and nuts and decreasing their consumption of refined cereals, added sugars, and sugar-sweetened beverages. After 6 mo, body weight, waist circumference (WC), systolic and diastolic blood pressure (BP), fasting blood glucose, glycated hemoglobin (HbA1c), triglyceride levels, triglycerides and glucose (TyG) index, and TyG-WC decreased across successive quintiles of improvement in the CQI. After 12 mo, improvements were additionally observed for HDL cholesterol and for the ratio of total to HDL cholesterol. Favorable improvements (expressed in common units of SD and 95% CI) for quintile 5 compared with quintile 1 of CQI change were observed for most risk factors, including TyG-WC (SD −0.20; 95% CI −0.26, −0.15), HbA1c (SD −0.16; 95% CI −0.23, −0.10), weight (SD −0.12; 95% CI −0.14, −0.09), systolic BP (SD −0.11; 95% CI −0.19, −0.02) and diastolic BP (SD −0.11; 95% CI −0.19, −0.04)., [Conclusions]: Improvements in CQI were strongly associated with concurrent favorable CVD risk factor changes maintained over time in overweight/obese adults with MetS. This trial was registered as ISRCTN 89898870.

Published
2020

28. Relationship between visceral adipose tissue and triglyceride glucose index with liver status in men and women with metabolic syndrome features: sex differences

Author

Bullón-Vela, Vanessa, primary, Abete, Itziar, additional, Tur, Josep A., additional, Konieczna, Jadwiga, additional, Romaguera, Dora, additional, Pintó, Xavier, additional, Corbella, Emili, additional, Martínez-González, Miguel A., additional, Sayón-Orea, Carmen, additional, Toledo, Estefanía, additional, Corella, Dolores, additional, Macias-Gonzalez, Manuel, additional, Tinahones, Francisco J., additional, Fitó, Montserrat, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Salas-Salvadó, Jordi, additional, Daimiel, Lidia, additional, Mascaró, Catalina M., additional, Zulet, M. Angeles, additional, and Martínez, J. Alfredo, additional

Published
2020
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31. Association between dairy product consumption and hyperuricemia in an elderly population with metabolic syndrome

Author

Mena-Sánchez, Guillermo, primary, Babio, Nancy, additional, Becerra-Tomás, Nerea, additional, Martínez-González, Miguel Á., additional, Díaz-López, Andrés, additional, Corella, Dolores, additional, Zomeño, Maria D., additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, José A., additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Bernal, Rosa, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, Lopez-Miranda, José, additional, Cano-Ibáñez, Naomi, additional, Gaforio, Jose J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Caro, José L. Llisterri, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emili, additional, Arellano, Ana Garcia, additional, Palau, Antoni, additional, Fernández-Carrión, Rebeca, additional, Pérez-Vega, Karla A., additional, Morey, Marga, additional, de la Hera, Manoli García, additional, Vaquero-Luna, Jessica, additional, Carmona-González, Francisco J., additional, Abete, Itziar, additional, Álvarez-Pérez, Jacqueline, additional, Casas, Rosa, additional, Fernández-García, José C., additional, Santos-Lozano, José M., additional, Corbella, Emili, additional, Sureda, Antoni, additional, Ruiz-Canela, Miguel, additional, Barragán, Rocio, additional, Goday, Albert, additional, Martín, Marian, additional, Altozano Rodado, María C., additional, Toledo, Estefanía, additional, Fitó, Montse, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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32. Carbohydrate quality changes and concurrent changes in cardiovascular risk factors: a longitudinal analysis in the PREDIMED-Plus randomized trial

Author

Martínez-González, Miguel A, primary, Fernandez-Lazaro, Cesar I, additional, Toledo, Estefanía, additional, Díaz-López, Andrés, additional, Corella, Dolores, additional, Goday, Albert, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M, additional, Wärnberg, Julia, additional, Martínez, J Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A, additional, López-Miranda, José, additional, Cano-Ibáñez, Naomi, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez, Vicente Martín, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Portoles, Olga, additional, Soria-Florido, María, additional, Konieczna, Jadwiga, additional, Navarrete-Muñoz, Eva M, additional, Tojal-Sierra, Lucas, additional, Fernández-García, José C, additional, Abete, Itziar, additional, Henríquez-Sánchez, Patricia, additional, Muñoz-Garach, Araceli, additional, Santos-Lozano, José M, additional, Corbella, Emili, additional, del Mar Bibiloni, Maria, additional, Becerra-Tomás, Nerea, additional, Barragán, Rocío, additional, Castañer, Olga, additional, Fiol, Miquel, additional, de la Hera, Manoli García, additional, Belló-Mora, María C, additional, Gea, Alfredo, additional, Babio, Nancy, additional, Fitó, Montse, additional, Ruiz-Canela, Miguel, additional, Zazpe, Itziar, additional, and Salas-Salvadó, Jordi, additional

Published
2020
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33. Relationship of visceral adipose tissue with surrogate insulin resistance and liver markers in individuals with metabolic syndrome chronic complications

Author

Bullón-Vela, Vanessa, primary, Abete, Itziar, additional, Tur, Josep A., additional, Konieczna, Jadwiga, additional, Romaguera, Dora, additional, Pintó, Xavier, additional, Corbella, Emili, additional, Martínez-González, Miguel A., additional, Sayón-Orea, Carmen, additional, Toledo, Estefanía, additional, Corella, Dolores, additional, Macías-Gonzalez, Manuel, additional, Tinahones, Francisco J., additional, Fitó, Montserrat, additional, Estruch, Ramon, additional, Ros, Emilio, additional, Salas-Salvadó, Jordi, additional, Daimiel, Lidia, additional, Mascaró, Catalina M., additional, Zulet, Maria Angeles, additional, and Martínez, José Alfredo, additional

Published
2020
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34. Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players

Author

Corpas, Rubén, primary, Solana, Elisabeth, additional, De la Rosa, Adrian, additional, Sarroca, Sara, additional, Griñán-Ferré, Christian, additional, Oriol, Mireia, additional, Corbella, Emili, additional, Rodríguez-Farré, Eduard, additional, Vina, Jose, additional, Pallàs, Mercè, additional, Bartrés-Faz, David, additional, Gomez-Cabrera, Mari Carmen, additional, and Sanfeliu, Coral, additional

Published
2019
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36. Long-term physical activity induces brain resilience in middle-aged adults

Author

Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., Sanfeliu, Coral, Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), and Generalitat de Catalunya

Abstract

Trabajo presentado en la Jornada Científica CIBERESP (Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública), celebrada en Madrid (España), el 14 de noviembre de 2019, AIM: Physical activity practiced regularly is known to improve the well-being and to reduce the risk of age-related diseases. We aimed to determine the impact of long-term physical activity on memory maintenance and search for peripheral blood markers related to cognitive function that may be detectable at middle-age METHODS: We performed neuropsychological analyses to veteran amateur rugby players (n = 24, age: 46–68 y) and middleaged sedentary controls (n = 25, age: 47–67 y). We analyzed the expression of selected genes in whole blood mRNA of player and control groups and young sedentary controls (n = 21, age: 17–25 y). A young trained group (n = 16, age: 18–25 y) was added to analyze age-related response in circulating neurotrophins induced by chronic exercise, Ajut Mario Sàlvia i Ferret 2014, lnstitut d'Estudis Catalans; SAF2016‐77703, MINECO and ERDF; 2017-SGR-106, AGAUR.

Published
2019

37. Long-term sport practice induces brain resilience through SIRT1-SIRT3 axis in male veteran rugby players

Author

Sanfeliu, Coral, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), European Commission, and Generalitat de Catalunya

Abstract

Trabajo presentado en el FENS Regional Meeting, celebrado en Belgrado (Sebia), del 10 al 13 de julio de 2019, Aim: Physical exercise performed regularly is known to improve health and to reduce the risk of age-related diseases. We had previously reported improved immediate memory responses in a cohort of veteran rugby players as compared to control subjects with low physical activity. We hypothesized that long-term physically active middle-aged men have developed brain resilience that can be detected with the analysis of peripheral blood markers. Methods: We tested the expression of selected genes of longevity, inflammation, redox homeostasis, and trophic signaling in whole blood mRNA. Analyses were performed on blood samples of veteran rugby players (n=24) and controls (n=25) aged 45-65 year, and also young controls (aged 15-25 years) with low physical activity (n=21). Physical activity and other lifestyles were thoroughly recorded with standardized questionnaires. Results: Middle-aged control subjects showed lower levels of expression of SIRT1, SIRT3 and CAT than the young controls, although rugby players maintained the expression levels of these genes at a young-like level. No differences were detected in the inflammatory genes, although there was a tendency towards a decrease in trophic and transduction factors in middle-aged groups as compared to the young controls. A statistical study of Spearman’s correlations supported a positive effect of sporting activity on memory and executive functions through SIRT1, SIRT3 and antioxidant gene expression levels in the veteran rugby players. Conclusions: Our results suggest the involvement of the SIRT1-SIRT3 axis, and the downstream antioxidant and neuroprotective signaling, in the anti-aging resilience of the brain mediated by physical exercise, Ajut Mario Sàlvia i Ferret 2014, lnstitut d’Estudis Catalans; SAF2016‐77703, MINECO and ERDF; 2017-SGR-106, AGAUR.

Published
2019

38. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., Rekondo, Javier, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., and Rekondo, Javier

Abstract

[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts., [Design]: We assessed 18,566 participants in the “Seguimiento Universidad de Navarra” (SUN) cohort followed-up during 188,891 person-years and 6790 participants in the “PREvencion con DIeta MEDiterránea” (PREDIMED) randomized trial representing 30,233 person-years of follow-up. DII scores were calculated in both cohorts from validated FFQs. Higher DII scores corresponded to more proinflammatory diets. A total of 230 and 302 deaths occurred in SUN and PREDIMED, respectively. In a random-effect meta-analysis we included 12 prospective studies (SUN, PREDIMED and 10 additional studies) that assessed the association between DII scores and all-cause mortality., [Results]: After adjusting for a wide array of potential confounders, the comparison between extreme quartiles of the DII showed a positive and significant association with all-cause mortality in both the SUN (hazard ratio [HR] = 1.85; 95% CI: 1.15, 2.98; P-trend = 0.004) and the PREDIMED cohort (HR = 1.42; 95% CI: 1.00, 2.02; P-trend = 0.009). In the meta-analysis of 12 cohorts, the DII was significantly associated with an increase of 23% in all-cause mortality (95% CI: 16%–32%, for the highest vs lowest category of DII)., [Conclusion]: Our results provide strong and consistent support for the hypothesis that a pro-inflammatory diet is associated with increased all-cause mortality. The SUN cohort and PREDIMED trial were registered at clinicaltrials.gov as NCT02669602 and at isrctn.com as ISRCTN35739639, respectively.

Published
2019

39. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic SyndromeInterim Analysis of the PREDIMED-Plus Randomized Clinical Trial

Author

European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, Martínez-González, Miguel Ángel, European Research Council, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Instituto de Salud Carlos III, European Commission, Fundación la Caixa, Sociedad Española de Médicos de Atención Primaria, International Nut and Dried Fruit, AstraZeneca, Junta de Andalucía, Generalitat Valenciana, Govern de les Illes Balears, Sayón-Orea, Carmen, Razquin, Cristina, Bulló, Mònica, Corella, Dolores, Fitó, Montserrat, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Delgado-Rodríguez, Miguel, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Ruiz-Canela, Miguel, Sorlí, José V., Castañer, Olga, Fiol, Miquel, Navarrete-Muñoz, María A., Arós, Fernando, Gómez-Gracia, Enrique, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bouzas, Cristina, García-Arellano, Ana, Basora, Josep, Asensio, Eva M., Schröder, Helmut, Moñino, Manuel, García-de-la-Hera, Manoli, Tojal Sierra, Lucas, Toledo, Estefania, Díaz-López, Andrés, Goday, Alberto, Salas-Salvadó, Jordi, and Martínez-González, Miguel Ángel

Abstract

[Importance] High-quality dietary patterns may help prevent chronic disease, but limited data exist from randomized trials about the effects of nutritional and behavioral interventions on dietary changes., [Objective] To assess the effect of a nutritional and physical activity education program on dietary quality., [Design, Setting, and Participants] Preliminary exploratory interim analysis of an ongoing randomized trial. In 23 research centers in Spain, 6874 men and women aged 55 to 75 years with metabolic syndrome and no cardiovascular disease were enrolled in the trial between September 2013 and December 2016, with final data collection in March 2019., [Interventions] Participants were randomized to an intervention group that encouraged an energy-reduced Mediterranean diet, promoted physical activity, and provided behavioral support (n = 3406) or to a control group that encouraged an energy-unrestricted Mediterranean diet (n = 3468). All participants received allotments of extra-virgin olive oil (1 L/mo) and nuts (125 g/mo) for free., [Main Outcomes and Measures] The primary outcome was 12-month change in adherence based on the energy-reduced Mediterranean diet (er-MedDiet) score (range, 0-17; higher scores indicate greater adherence; minimal clinically important difference, 1 point)., [Results] Among 6874 randomized participants (mean [SD] age, 65.0 [4.9] years; 3406 [52%] men), 6583 (96%) completed the 12-month follow-up and were included in the main analysis. The mean (SD) er-MedDiet score was 8.5 (2.6) at baseline and 13.2 (2.7) at 12 months in the intervention group (increase, 4.7 [95% CI, 4.6-4.8]) and 8.6 (2.7) at baseline and 11.1 (2.8) at 12 months in the control group (increase, 2.5 [95% CI, 2.3-2.6]) (between-group difference, 2.2 [95% CI, 2.1-2.4]; P < .001)., [Conclusions and Relevance] In this preliminary analysis of an ongoing trial, an intervention that encouraged an energy-reduced Mediterranean diet and physical activity, compared with advice to follow an energy-unrestricted Mediterranean diet, resulted in a significantly greater increase in diet adherence after 12 months. Further evaluation of long-term cardiovascular effects is needed., [Trial Registration] isrctn.com Identifier: ISRCTN89898870.

Published
2019

40. Cross-sectional association between non-soy legume consumption, serum uric acid and hyperuricemia: the PREDIMED-Plus study

Author

Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, Salas-Salvadó, Jordi, Instituto de Salud Carlos III, European Commission, European Research Council, Junta de Andalucía, Generalitat Valenciana, Becerra-Tomás, Nerea, Mena-Sánchez, Guillermo, Díaz-López, Andrés, Martínez-González, Miguel Ángel, Babio, Nancy, Corella, Dolores, Freixer, Gala, Romaguera, Dora, Vioque, Jesús, Alonso-Gómez, Ángel M., Wärnberg, Julia, Martínez, Alfredo J., Serra-Majem, Lluis, Estruch, Ramón, Fernández-García, José C., Lapetra, José, Pintó, Xavier, Tur, Josep A., López-Miranda, José, Bueno-Cavanillas, Aurora, Gaforio, José Juan, Matía-Martín, Pilar, Daimiel, Lidia, Martín-Sánchez, Vicente, Vidal, Josep, Vázquez, Clotilde, Ros, Emilio, Razquin, Cristina, Abellán Cano, Iván, Sorlí, José V., Torres, Laura, Morey, Marga, Navarrete-Muñoz, María A., Tojal Sierra, Lucas, Crespo-Oliva, Edelys, Zulet, M. Ángeles, Sanchez-Villegas, Almudena, Casas, Rosa, Bernal-Lopez, M, Rosa, Santos-Lozano, J. M., Corbella, Emili, Bibiloni, Maria del Mar, Ruiz-Canela, Miguel, Fernández-Carrión, Rebeca, Quifer, Mireia, Prieto, Rafel M., Fernandez-Brufal, Noelia, Salaverria Lete, Itziar, Cenoz, Juan Carlos, Llimona, Regina, and Salas-Salvadó, Jordi

Abstract

[Purpose]: To assess the association between the consumption of non-soy legumes and different subtypes of non-soy legumes and serum uric acid (SUA) or hyperuricemia in elderly individuals with overweight or obesity and metabolic syndrome. [Methods]:A cross-sectional analysis was conducted in the framework of the PREDIMED-Plus study. We included 6329 participants with information on non-soy legume consumption and SUA levels. Non-soy legume consumption was estimated using a semi-quantitative food frequency questionnaire. Linear regression models and Cox regression models were used to assess the associations between tertiles of non-soy legume consumption, different subtypes of non-soy legume consumption and SUA levels or hyperuricemia prevalence, respectively., [Results]: Individuals in the highest tertile (T3) of total non-soy legume, lentil and pea consumption, had 0.14 mg/dL, 0.19 mg/dL and 0.12 mg/dL lower SUA levels, respectively, compared to those in the lowest tertile (T1), which was considered the reference one. Chickpea and dry bean consumption showed no association. In multivariable models, participants located in the top tertile of total non-soy legumes [prevalence ratio (PR): 0.89; 95% CI 0.82–0.97; p trend = 0.01, lentils (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01), dry beans (PR: 0.91; 95% C: 0.84–0.99; p trend = 0.03) and peas (PR: 0.89; 95% CI 0.82–0.97; p trend = 0.01)] presented a lower prevalence of hyperuricemia (vs. the bottom tertile). Chickpea consumption was not associated with hyperuricemia prevalence., [Conclusions]: In this study of elderly subjects with metabolic syndrome, we observed that despite being a purine-rich food, non-soy legumes were inversely associated with SUA levels and hyperuricemia prevalence.

Published
2019

41. Peripheral Maintenance of the Axis SIRT1-SIRT3 at Youth Level May Contribute to Brain Resilience in Middle-Aged Amateur Rugby Players

Author

Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), European Commission, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., Sanfeliu, Coral, Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), European Commission, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., and Sanfeliu, Coral

Abstract

Physical exercise performed regularly is known to improve health and to reduce the risk of age-related diseases. Furthermore, there is some evidence of cognitive improvement in physically active middle-aged and older adults. We hypothesized that long-term physically active middle-aged men may have developed brain resilience that can be detected with the analysis of peripheral blood markers. We aimed to analyze the activation of pathways potentially modulated by physical activity in a cohort of healthy amateur rugby players (n = 24) and control subjects with low physical activity (n = 25) aged 45¿65 years. We had previously reported neuropsychological improvement in immediate memory responses in the player group compared to the controls. Here, we tested the expression of selected genes of longevity, inflammation, redox homeostasis, and trophic signaling in whole blood mRNA. Analyses were also performed on blood samples of young (aged 15¿25 years) control subjects with low physical activity (n = 21). Physical activity and other lifestyle factors were thoroughly recorded with standardized questionnaires. Interestingly, middle-aged control subjects showed lower levels of expression of SIRT1, SIRT3, CAT, and SOD1 than the young controls, although rugby players maintained the expression levels of these genes at a young-like level. Middle-aged players showed lower levels of IL1B than the non-physically active groups. However, there was a tendency towards a decrease in trophic and transduction factors in middle-aged groups as compared to the young controls. A statistical study of Spearman¿s correlations supported a positive effect of sporting activity on memory and executive functions, and on peripheral gene expression of SIRT1, SIRT3 and downstream genes, in the middle-aged rugby players. Our results indicate that the SIRT1-SIRT3 axis, and associated neuroprotective signaling, may contribute to the anti-aging resilience of the brain mediated by physical exercise.

Published
2019

42. Long-term physical activity induces brain resilience in middle-aged adults

Author

Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., Sanfeliu, Coral, Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), Generalitat de Catalunya, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., and Sanfeliu, Coral

Abstract

AIM: Physical activity practiced regularly is known to improve the well-being and to reduce the risk of age-related diseases. We aimed to determine the impact of long-term physical activity on memory maintenance and search for peripheral blood markers related to cognitive function that may be detectable at middle-age METHODS: We performed neuropsychological analyses to veteran amateur rugby players (n = 24, age: 46–68 y) and middleaged sedentary controls (n = 25, age: 47–67 y). We analyzed the expression of selected genes in whole blood mRNA of player and control groups and young sedentary controls (n = 21, age: 17–25 y). A young trained group (n = 16, age: 18–25 y) was added to analyze age-related response in circulating neurotrophins induced by chronic exercise

Published
2019

43. Long-term sport practice induces brain resilience through SIRT1-SIRT3 axis in male veteran rugby players

Author

Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Sanfeliu, Coral, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, Gómez-Cabrera, M. C., Institut d'Estudis Catalans, Ministerio de Economía y Competitividad (España), European Commission, Generalitat de Catalunya, Sanfeliu, Coral, Corpas, Rubén, Solana, Elisabeth, Rosa, Adrián de la, Sarroca, Sara, Griñán-Ferré, Christian, Oriol, Mireia, Corbella, Emili, Rodríguez-Farré, Eduard, Vina, Jose, Pallàs, Mercè, Bartrés-Faz, David, and Gómez-Cabrera, M. C.

Abstract

Aim: Physical exercise performed regularly is known to improve health and to reduce the risk of age-related diseases. We had previously reported improved immediate memory responses in a cohort of veteran rugby players as compared to control subjects with low physical activity. We hypothesized that long-term physically active middle-aged men have developed brain resilience that can be detected with the analysis of peripheral blood markers. Methods: We tested the expression of selected genes of longevity, inflammation, redox homeostasis, and trophic signaling in whole blood mRNA. Analyses were performed on blood samples of veteran rugby players (n=24) and controls (n=25) aged 45-65 year, and also young controls (aged 15-25 years) with low physical activity (n=21). Physical activity and other lifestyles were thoroughly recorded with standardized questionnaires. Results: Middle-aged control subjects showed lower levels of expression of SIRT1, SIRT3 and CAT than the young controls, although rugby players maintained the expression levels of these genes at a young-like level. No differences were detected in the inflammatory genes, although there was a tendency towards a decrease in trophic and transduction factors in middle-aged groups as compared to the young controls. A statistical study of Spearman’s correlations supported a positive effect of sporting activity on memory and executive functions through SIRT1, SIRT3 and antioxidant gene expression levels in the veteran rugby players. Conclusions: Our results suggest the involvement of the SIRT1-SIRT3 axis, and the downstream antioxidant and neuroprotective signaling, in the anti-aging resilience of the brain mediated by physical exercise

Published
2019

45. A Mediterranean Diet Rich in Extra-Virgin Olive Oil Is Associated with a Reduced Prevalence of Nonalcoholic Fatty Liver Disease in Older Individuals at High Cardiovascular Risk

Author

Pintó, Xavier, primary, Fanlo-Maresma, Marta, additional, Corbella, Emili, additional, Corbella, Xavier, additional, Mitjavila, M Teresa, additional, Moreno, Juan J, additional, Casas, Rosa, additional, Estruch, Ramon, additional, Corella, Dolores, additional, Bulló, Mònica, additional, Ruiz-Canela, Miguel, additional, Castañer, Olga, additional, Martinez, J Alfredo, additional, and Ros, Emilio, additional

Published
2019
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46. Effect of a Nutritional and Behavioral Intervention on Energy-Reduced Mediterranean Diet Adherence Among Patients With Metabolic Syndrome

Author

Sayón-Orea, Carmen, primary, Razquin, Cristina, additional, Bulló, Mónica, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, López-Miranda, José, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Sánchez, Vicente Martín, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Sorlí, José V., additional, Castañer, Olga, additional, Fiol, Miquel, additional, Navarrete-Muñoz, Eva M., additional, Arós, Fernando, additional, Gómez-Gracia, Enrique, additional, Zulet, M. Angeles, additional, Sánchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, Rosa, additional, Santos-Lozano, José M., additional, Corbella, Emili, additional, Bouzas, Cristina, additional, García-Arellano, Ana, additional, Basora, Josep, additional, Asensio, Eva M., additional, Schröder, Helmut, additional, Moñino, Manuel, additional, García de la Hera, Manoli, additional, Tojal-Sierra, Lucas, additional, Toledo, Estefanía, additional, Díaz-López, Andrés, additional, Goday, Albert, additional, Salas-Salvadó, Jordi, additional, and Martínez-González, Miguel A., additional

Published
2019
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47. Fluid and total water intake in a senior mediterranean population at high cardiovascular risk: demographic and lifestyle determinants in the PREDIMED-Plus study

Author

Paz-Graniel, Indira, primary, Babio, Nancy, additional, Serra-Majem, Luís, additional, Vioque, Jesús, additional, Zomeño, Maria Dolores, additional, Corella, Dolores, additional, Díaz-López, Andrés, additional, Pintó, Xavier, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Daimiel, Lidia, additional, Martínez, J. Alfredo, additional, Becerra-Tomás, Nerea, additional, Navarrete-Muñoz, Eva Mª, additional, Schröder, Helmut, additional, Fernández-Carrión, Rebeca, additional, Ortiz-Andrellucchi, Adriana, additional, Corbella, Emili, additional, Riquelme-Gallego, Blanca, additional, Gallardo-Alfaro, Laura, additional, Micó, Víctor, additional, Zulet, Marian, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Ruiz-Canela, Miguel, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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48. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author

Papandreou, Christopher, primary, Babio, Nancy, additional, Díaz-López, Andrés, additional, Martínez-González, Miguel, additional, Becerra-Tomas, Nerea, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Muñoz-Garach, Araceli, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Bulló, Mónica, additional, Sorli, Jose, additional, Quifer, Mireia, additional, Colom, Antoni, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Fernández-Garcia, José, additional, Santos-Lozano, José, additional, Corbella, Emili, additional, del M. Bibiloni, Maria, additional, Diez-Espino, Javier, additional, Asensio, Eva, additional, Torras, Laura, additional, Morey, Marga, additional, Compañ-Gabucio, Laura, additional, Salaverria-Lete, Itziar, additional, Cenoz-Osinaga, Juan, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional

Published
2019
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49. Risk factors differentially associated with non-alcoholic fatty liver disease in males and females with metabolic syndrome

Author

Bullón Vela, María Vanessa, primary, Abete, Itziar, additional, Zulet, María de los Ángeles, additional, Tur, Josep A., additional, Pintó, Xavier, additional, Corbella, Emili, additional, Martínez González, Miguel Ángel, additional, Corella, Dolores, additional, Macías, Manuel, additional, Tinahones, Francisco, additional, Fitó, Montserrat, additional, Estruch, Ramón, additional, Ros, Emilio, additional, Salas Salvadó, Jordi, additional, Daimiel, Lidia, additional, and Martínez, J. Alfredo, additional

Published
2019
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50. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Author

Becerra-Tomás, Nerea, Díaz-López, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., Estruch, R., Fitó, Montserrat, Serra-Majem, L., Arós, F., Lamuela-Raventós, Rosa M., Gueto Rubio, M.V., Loma-Osorio, A., Gómez-Gracia, Enrique, Wärnberg, J., Duaso, I., Rovira, M.A., Benítez Pont, R., Perona, Javier S., Bianchi Alba, M., de la Cruz, E., Basora, J., Brau, A., Salas-Salvadó, J., Bonet, M.T., Gómez-Huelgas, R., Guillén, M., Martínez-González, J., Berrade, N., Molina, C., Casas, Ricard, Sáez, G., Guasch-Ferré, Marta, Iglesias, C., Serra-Mir, M., Velasco García, V., Márquez, F., Montero Romero, Emilio, Vila, J., García-García, M., del Hierro, T., Coltell, O., Jurado-Ruíz, Enrique, Cabré, J.J., Romaguera, D., Valero-Barceló, C., García, M., Costa-Vizcaino, J., Altirriba, J., Prieto, R., García-Valdueza, M., Frontera, G., Fiol, F., Ginard, M., Mestres, G., García, Y., Jover, A., Sorlí, M., Ibarrola-Jurado, Nuria, Molina, N., García, J., Salas-Huetos, A., López-Sabater, M.C., Martínez-Lapiscina, E.H., García Pastor, J.A., Sánchez Luque, J.J., González, J.I., Martín, F., Manzano, E., Fanlo-Maresma, M., Viñas, C., Sáiz, C., Galera, A., Churio-Beraza, B., Trias, F., Bestard, F., Extremera-Urabayen, V., de la Torre, Rafael, Medina-Remón, Alexander, Tort, N., Tello, S., Papandreou, C., Verdú, J.M., Sarasa, I., Muñoz-Aguayo, Daniel, Baby, P., Baena, J.M., Paris, F., Ramos, A., Díaz-Benítez, E.M., Francisco, S., Mengual, L., Ruiz-Canela, M., Roura, P., de Diego Salas, J., Castro Dorado, Antonio, Goñi, E., Fernández-Carrión, R., Fernández-Ballart, J., Yuste, M.C., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Sanjulián, B., Montañes, D., Forga, L., Schröder, H., Marrugat, J., Llauradó, M., Giménez, F.J., Gallego, J., Vázquez, Z., García-Layana, A., Moñino, M., Larrauri, A., Vinyoles, E., Rovira, A., Guillem-Saiz, P., Eguaras, S., Simón, C., Oller, M., Salaverria, I., Quinzavos, L., Quifer-Rada, P., Parra, L., de Juan, C., Sarmiento de la Fe, F., Liroz, M., Benavent, J., Castellote-Bargalló, Ana I., Farré, M., Baca Osorio, A., Arroyo-Azpa, C., Altés, A., Clos, J., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Sánchez-Tainta, A., Doménech, M., Portolés, Olga, Algorta, J., Pérez-Cabrera, J., Bulló, M., Gil Zarzosa, J., Babio, N., Corbella, Emili, Maestre, E., Munuera, S., Sanz, E., García-Pérez, L., Pedret, R., Isach, A., Vivó, M., Basells, J., Guarner, A., Vizcaino, J., Martín, M. T., Tresserra-Rimbau, A., Castañer, O., Rekondo, J., Díaz-González, B.V., Ruiz-Gutiérrez, Valentina, Carrasco, P., Segarra, R., Álvarez-Pérez, J., Ortega-Azorín, Carolina, Fiol, Miquel, Asensio, E.M., Martínez, P., Tur, J.A., Osma, R., Castillo Anzalas, J.M., Barragán, R., Portu-Zapirain, J., Alonso-Gómez, A., Corbella, X., Coll, L., González-Monje, I., Francés, F., Quiles, L., Pascual, V., Riera, C., Sosa-Also, R.E., Vargas López, E., Pages, M.A., Casañas-Quintana, L.T., Sánchez-Villegas, A., Pérez-Heras, A., Godoy, D., Cabezas, C., Carratalá-Calvo, A., Pla, I., Sánchez-Navarro, S., Boj, J., Santamaría, M.I., Bautista-Castaño, Inmaculada, Proenza, A., Martí, A., Toledo, E., Mata, M., González, R., SerranoMartínez, M., Sánchez, M.S., Díez-Espino, Javier, Santos-Lozano, J.M., Munar, J.A., Timiraus-Fernández, J., García, L., Villanueva-Tellería, J., García-Arellano, A., Cortés-Ugalde, F., Sagredo-Arce, T., Medina-Ponce, J., Vigata-López, M.D., Elosua, R., García Roselló, J., Arceiz Campo, M.T., Amat, J., Urtasun-Samper, A., Frigola, J., Ruano-Rodríguez, C., Amorós, M., Portillo, María P., Flores-Mateo, Gemma, Belló, M.C., Becerra-Tomás, Nerea, Díaz-López, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., Estruch, R., Fitó, Montserrat, Serra-Majem, L., Arós, F., Lamuela-Raventós, Rosa M., Gueto Rubio, M.V., Loma-Osorio, A., Gómez-Gracia, Enrique, Wärnberg, J., Duaso, I., Rovira, M.A., Benítez Pont, R., Perona, Javier S., Bianchi Alba, M., de la Cruz, E., Basora, J., Brau, A., Salas-Salvadó, J., Bonet, M.T., Gómez-Huelgas, R., Guillén, M., Martínez-González, J., Berrade, N., Molina, C., Casas, Ricard, Sáez, G., Guasch-Ferré, Marta, Iglesias, C., Serra-Mir, M., Velasco García, V., Márquez, F., Montero Romero, Emilio, Vila, J., García-García, M., del Hierro, T., Coltell, O., Jurado-Ruíz, Enrique, Cabré, J.J., Romaguera, D., Valero-Barceló, C., García, M., Costa-Vizcaino, J., Altirriba, J., Prieto, R., García-Valdueza, M., Frontera, G., Fiol, F., Ginard, M., Mestres, G., García, Y., Jover, A., Sorlí, M., Ibarrola-Jurado, Nuria, Molina, N., García, J., Salas-Huetos, A., López-Sabater, M.C., Martínez-Lapiscina, E.H., García Pastor, J.A., Sánchez Luque, J.J., González, J.I., Martín, F., Manzano, E., Fanlo-Maresma, M., Viñas, C., Sáiz, C., Galera, A., Churio-Beraza, B., Trias, F., Bestard, F., Extremera-Urabayen, V., de la Torre, Rafael, Medina-Remón, Alexander, Tort, N., Tello, S., Papandreou, C., Verdú, J.M., Sarasa, I., Muñoz-Aguayo, Daniel, Baby, P., Baena, J.M., Paris, F., Ramos, A., Díaz-Benítez, E.M., Francisco, S., Mengual, L., Ruiz-Canela, M., Roura, P., de Diego Salas, J., Castro Dorado, Antonio, Goñi, E., Fernández-Carrión, R., Fernández-Ballart, J., Yuste, M.C., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Sanjulián, B., Montañes, D., Forga, L., Schröder, H., Marrugat, J., Llauradó, M., Giménez, F.J., Gallego, J., Vázquez, Z., García-Layana, A., Moñino, M., Larrauri, A., Vinyoles, E., Rovira, A., Guillem-Saiz, P., Eguaras, S., Simón, C., Oller, M., Salaverria, I., Quinzavos, L., Quifer-Rada, P., Parra, L., de Juan, C., Sarmiento de la Fe, F., Liroz, M., Benavent, J., Castellote-Bargalló, Ana I., Farré, M., Baca Osorio, A., Arroyo-Azpa, C., Altés, A., Clos, J., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Sánchez-Tainta, A., Doménech, M., Portolés, Olga, Algorta, J., Pérez-Cabrera, J., Bulló, M., Gil Zarzosa, J., Babio, N., Corbella, Emili, Maestre, E., Munuera, S., Sanz, E., García-Pérez, L., Pedret, R., Isach, A., Vivó, M., Basells, J., Guarner, A., Vizcaino, J., Martín, M. T., Tresserra-Rimbau, A., Castañer, O., Rekondo, J., Díaz-González, B.V., Ruiz-Gutiérrez, Valentina, Carrasco, P., Segarra, R., Álvarez-Pérez, J., Ortega-Azorín, Carolina, Fiol, Miquel, Asensio, E.M., Martínez, P., Tur, J.A., Osma, R., Castillo Anzalas, J.M., Barragán, R., Portu-Zapirain, J., Alonso-Gómez, A., Corbella, X., Coll, L., González-Monje, I., Francés, F., Quiles, L., Pascual, V., Riera, C., Sosa-Also, R.E., Vargas López, E., Pages, M.A., Casañas-Quintana, L.T., Sánchez-Villegas, A., Pérez-Heras, A., Godoy, D., Cabezas, C., Carratalá-Calvo, A., Pla, I., Sánchez-Navarro, S., Boj, J., Santamaría, M.I., Bautista-Castaño, Inmaculada, Proenza, A., Martí, A., Toledo, E., Mata, M., González, R., SerranoMartínez, M., Sánchez, M.S., Díez-Espino, Javier, Santos-Lozano, J.M., Munar, J.A., Timiraus-Fernández, J., García, L., Villanueva-Tellería, J., García-Arellano, A., Cortés-Ugalde, F., Sagredo-Arce, T., Medina-Ponce, J., Vigata-López, M.D., Elosua, R., García Roselló, J., Arceiz Campo, M.T., Amat, J., Urtasun-Samper, A., Frigola, J., Ruano-Rodríguez, C., Amorós, M., Portillo, María P., Flores-Mateo, Gemma, and Belló, M.C.

Abstract

Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration dat

Published
2018

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