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21 results on '"Coraglio, Mariana"'

4. International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy.

Author

El Sissy, Carine, Kirilovsky, Amos, Lagorce Pagès, Christine, Marliot, Florence, Custers, Petra A., Dizdarevic, Edina, Sroussi, Marine, Castillo-Martin, Mireia, Haicheur, Nacilla, Dermani, Mohamed, Loche, Nicolas, Buttard, Bénedicte, Musina, Ana Maria, Anitei, Maria Gabriela, van den Berg, José G., Broeks, Annegien, Iseas, Soledad, Coraglio, Mariana, Loria, Fernando Sanchez, and Romero, Alfredo

Published
2024
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5. Prognostic Factors of Long-Term Outcomes after Primary Chemo-Radiotherapy in Non-Metastatic Anal Squamous Cell Carcinoma: An International Bicentric Cohort

Author

Iseas, Soledad, primary, Prost, Diego, additional, Bouchereau, Sarah, additional, Golubicki, Mariano, additional, Robbio, Juan, additional, Oviedo, Ana, additional, Coraglio, Mariana, additional, Kujaruk, Mirta, additional, Méndez, Guillermo, additional, Carballido, Marcela, additional, Roca, Enrique, additional, Gros, Louis, additional, De Parades, Vincent, additional, Baba-Hamed, Nabil, additional, Adam, Julien, additional, Abba, Martín Carlos, additional, and Raymond, Eric, additional

Published
2023
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7. Mono- and biallelic germline variants of DNA glycosylase genes in colon adenomatous polyposis families from two continents

Author

Olkinuora, Alisa Petriina, primary, Mayordomo, Andrea Constanza, additional, Kauppinen, Anni Katariina, additional, Cerliani, María Belén, additional, Coraglio, Mariana, additional, Collia, Ávila Karina, additional, Gutiérrez, Alejandro, additional, Alvarez, Karin, additional, Cassana, Alessandra, additional, Lopéz-Köstner, Francisco, additional, Jauk, Federico, additional, García-Rivello, Hernán, additional, Ristimäki, Ari, additional, Koskenvuo, Laura, additional, Lepistö, Anna, additional, Nieminen, Taina Tuulikki, additional, Vaccaro, Carlos Alberto, additional, Pavicic, Walter Hernán, additional, and Peltomäki, Päivi, additional

Published
2022
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8. Prognostic Impact of An Integrative Landscape of Clinical, Immune, and Molecular Features in Non-Metastatic Rectal Cancer

Author

Iseas, Soledad, primary, Sendoya, Juan M., additional, Robbio, Juan, additional, Coraglio, Mariana, additional, Kujaruk, Mirta, additional, Mikolaitis, Vanesa, additional, Rizzolo, Mariana, additional, Cabanne, Ana, additional, Ruiz, Gonzalo, additional, Salanova, Rubén, additional, Gualdrini, Ubaldo, additional, Méndez, Guillermo, additional, Antelo, Marina, additional, Carballido, Marcela, additional, Rotondaro, Cecilia, additional, Viglino, Julieta, additional, Eleta, Martín, additional, Di Sibio, Alejandro, additional, Podhajcer, Osvaldo L., additional, Roca, Enrique, additional, Llera, Andrea S., additional, Golubicki, Mariano, additional, and Abba, Martín Carlos, additional

Published
2022
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9. Pre-Existing Tumoral B Cell Infiltration and Impaired Genome Maintenance Correlate with Response to Chemoradiotherapy in Locally Advanced Rectal Cancer

Author

Sendoya, Juan M., primary, Iseas, Soledad, additional, Coraglio, Mariana, additional, Golubicki, Mariano, additional, Robbio, Juan, additional, Salanova, Ruben, additional, Kujaruk, Mirta, additional, Mikolaitis, Vanesa, additional, Rizzolo, Mariana, additional, Ruiz, Gonzalo, additional, Cabanne, Ana, additional, Gualdrini, Ubaldo, additional, Mendez, Guillermo, additional, Hirmas, Stella, additional, Rotondaro, Cecilia, additional, Viglino, Julieta, additional, Eleta, Martín, additional, Fernandez, Elmer, additional, Abba, Martín, additional, Podhajcer, Osvaldo, additional, Roca, Enrique, additional, and Llera, Andrea S, additional

Published
2020
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10. PDL1 expression predicts therapeutic outcome in non metastatic anal squamous cell carcinoma (NMASCC).

Author

Iseas, Ilma Soledad, primary, Golubicki, Mariano, additional, Robbio, Juan, additional, Ruiz, Gonzalo, additional, Salanova, Ruben, additional, Mariani, Javier, additional, Slutsky, Ezequiel, additional, Vecchioni, Daniela, additional, Oviedo, Ana, additional, Guerra, Florencia, additional, Maquieira, Julian, additional, Basilletti, Jorge, additional, Picconi, Alejandra, additional, Roca, Enrique, additional, Mendez, Guillermo, additional, and Coraglio, Mariana, additional

Published
2020
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11. TarSeqQC: Quality control on targeted sequencing experiments in R

Author

Merino, Gabriela Alejandra, Murua, Yanina Alejandra, Fresno Rodríguez, Cristóbal, Sendoya, Juan Martín, Golubicki, Mariano, Iseas, Soledad, Coraglio, Mariana, Podhajcer, Osvaldo Luis, Llera, Andrea Sabina, and Fernandez, Elmer Andres

Subjects
CANCER PANEL, Ciencias de la Computación e Información, QUALITY CONTROL, MEDICAL GENETICS, EXPERIMENT PERFORMANCE, TARGETED SEQUENCING, R PACKAGE, CIENCIAS NATURALES Y EXACTAS, Ciencias de la Computación
Abstract

Targeted sequencing (TS) is growing as a screening methodology used in research and medical genetics to identify genomic alterations causing human diseases. In general, a list of possible genomic variants is derived from mapped reads through a variant calling step. This processing step is usually based on variant coverage, although it may be affected by several factors. Therefore, undercovered relevant clinical variants may not be reported, affecting pathology diagnosis or treatment. Thus, a prior quality control of the experiment is critical to determine variant detection accuracy and to avoid erroneous medical conclusions. There are several quality control tools, but they are focused on issues related to whole-genome sequencing. However, in TS, quality control should assess experiment, gene, and genomic region performances based on achieved coverages. Here, we propose TarSeqQC R package for quality control in TS experiments. The tool is freely available at Bioconductor repository. TarSeqQC was used to analyze two datasets; low-performance primer pools and features were detected, enhancing the quality of experiment results. Read count profiles were also explored, showing TarSeqQC's effectiveness as an exploration tool. Our proposal may be a valuable bioinformatic tool for routinely TS experiments in both research and medical genetics. Fil: Merino, Gabriela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Area de Ciencias Agrarias, Ingeniería, Ciencias Biológicas y de la Salud de la Universidad Católica de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina Fil: Murua, Yanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Fresno Rodríguez, Cristóbal. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Area de Ciencias Agrarias, Ingeniería, Ciencias Biológicas y de la Salud de la Universidad Católica de Córdoba; Argentina Fil: Sendoya, Juan Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Golubicki, Mariano. Intergrupo Argentino para el Tratamiento de los Tumores Gastrointestinales; Argentina Fil: Iseas, Soledad. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Coraglio, Mariana. Gobierno de la Ciudad de Buenos Aires. Hospital de Gastroenterología "Dr. Carlos B. Udaondo"; Argentina Fil: Podhajcer, Osvaldo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Llera, Andrea Sabina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Fernandez, Elmer Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Area de Ciencias Agrarias, Ingeniería, Ciencias Biológicas y de la Salud de la Universidad Católica de Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina

Published
2017
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12. Abstract LB-374: Transcriptome-based inference of immune cell subsets and pathway deregulation in rectal cancer reveals biological processes related to therapy response

Author

Sendoya, Juan M., primary, Iseas, Soledad, additional, Golubicki, Mariano, additional, Robbio, Juan, additional, Coraglio, Mariana F., additional, Gualdrini, Ubaldo, additional, Cabanne, Ana, additional, Kujaruk, Mirta, additional, Mikolaitis, Vanesa, additional, Rizzolo, Mariana, additional, Salanova, Ruben, additional, Rotondaro, Cecilia, additional, Abba, Martin, additional, Podhajcer, Osvaldo, additional, Roca, Enrique, additional, and Llera, Andrea, additional

Published
2018
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13. Comprehensive clinical, pathological and molecular characterization of a cohort of locally advanced rectal cancer patients: Towards an integrative classification for rectal cancer management

Author

Iseas, Soledad, primary, Sendoya Juan, Martin, additional, Golubicki, Mariano, additional, Coraglio, Mariana, additional, Gualdrini, Ubaldo, additional, Cabanne, Ana, additional, Kujaruk, Mirta, additional, Mikolaitis, Vanesa, additional, Rizzolo, Mariana, additional, Salanova, Ruben, additional, Eleta, Martin, additional, Irmas, Stella, additional, Rotondaro, Cecilia, additional, Ink, Maximiliano, additional, Elmer, Fernandez, additional, Podhajcer, Osvaldo, additional, Llera, Andrea, additional, and Roca, Enrique, additional

Published
2017
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14. TarSeqQC: Quality control on targeted sequencing experiments in R

Author

Merino, Gabriela A., primary, Murua, Yanina A., additional, Fresno, Cristóbal, additional, Sendoya, Juan M., additional, Golubicki, Mariano, additional, Iseas, Soledad, additional, Coraglio, Mariana, additional, Podhajcer, Osvaldo L., additional, Llera, Andrea S., additional, and Fernández, Elmer A., additional

Published
2017
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15. Moving foward and beyond the standard through a non-operative management in rectal cancer? Our watch and wait approach experience in Co-Recto.

Author

Iseas, Ilma Soledad, primary, Carballido, Marcela, additional, Coraglio, Mariana, additional, Leiro, Fabio, additional, Dieguez, Adriana, additional, Eleta, Martin, additional, Bianchi, Romina, additional, Bertoncini, Cintia, additional, Mendez, Guillermo Ariel, additional, Barugel, Mario Edmundo, additional, and Roca, Enrique Luis, additional

Published
2015
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16. P-357 - Comprehensive clinical, pathological and molecular characterization of a cohort of locally advanced rectal cancer patients: Towards an integrative classification for rectal cancer management

Author

Iseas, Soledad, Sendoya Juan, Martin, Golubicki, Mariano, Coraglio, Mariana, Gualdrini, Ubaldo, Cabanne, Ana, Kujaruk, Mirta, Mikolaitis, Vanesa, Rizzolo, Mariana, Salanova, Ruben, Eleta, Martin, Irmas, Stella, Rotondaro, Cecilia, Ink, Maximiliano, Elmer, Fernandez, Podhajcer, Osvaldo, Llera, Andrea, and Roca, Enrique

Published
2017
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17. Prognostic factors of long-term outcomes after primary chemo-radiotherapy in non-metastatic anal squamous cell carcinoma: An international bicentric cohort.

Author

Iseas, Soledad, Prost, Diego Martín, Bouchereau, Sarah, Golubicki, Mariano, Robbio, Juan, Oviedo, Ana, Coraglio, Mariana, Carballido, Marcela, Kujaruk, Mirta, Mendez, Guillermo, Barugel, Mario Edmundo, Roca, Enrique, Gros, Louis, de Parades, Vincent, Baba-Hamed, Nabil, Adam, Julien, Abba, Martin C, and Raymond, Eric

Published
2023
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18. Still Awaiting That Waiting Be a Validated Affordable Option in Rectal Cancer? Our Watch and Wait Approach Experience in Co-Recto

Author

Carballido Marcela, Roca Enrique, Coraglio Mariana, Eleta Martin, Barugel Mario, Leiro Fabio, Iseas Soledad, Dieguez Adriana, Mendez Guillermo, and Aguilo Ariel

Subjects
medicine.medical_specialty, Oncology, business.industry, Colorectal cancer, Rectal carcinoma, Medicine, Hematology, business, medicine.disease, Surgery
Published
2014
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19. P-0282 Facing Rectal Cancer Under the Age of 50: Analysis of 140 Patients Discussed in an Multidisciplinary Team (Co-Recto) in Argentina

Author

Iseas, Soledad, primary, Antelo, Marina, additional, Barugel, Mario, additional, Aguilo, Ariel, additional, Carballido, Marcela, additional, Mendez, Guillermo, additional, Dieguez, Adriana, additional, Leiro, Fabio, additional, Eleta, Martin, additional, Coraglio, Mariana, additional, Virginillo, Juan, additional, Mospane, Claudio, additional, and Roca, Enrique, additional

Published
2012
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20. [Prospective, double-blind study of topical phenylephrine treatment for nocturnal fecal incontinence in patients after ileoanal pouch construction].

Author

Lumi CM, La Rosa L, Coraglio MF, Muñoz JP, Gualdrini UA, and Masciangioli G

Subjects
Adult, Double-Blind Method, Fecal Incontinence etiology, Female, Humans, Male, Middle Aged, Prospective Studies, Adrenergic alpha-Agonists administration & dosage, Colonic Pouches adverse effects, Fecal Incontinence drug therapy, Phenylephrine administration & dosage
Abstract

Patients: Fecal incontinence has been reported in 5.5% to 45% of patients after ileoanal pouch construction, predominantly at night. It has been shown that alpha1-adrenergic agonists as phenylephrine increase anal sphincter pressure in healthy volunteers and in patients with idiopathic fecal incontinence. The median duration of action of topical phenylephrine is seven hours. Carapeti et al have demonstrated its usefulness in patients after ileoanal pouch construction., Objective: To demonstrate that the administration of a single dose of topical 10% phenylephrine at night is effective for the treatment of nocturnal anal incontinence in this group of patients., Patients and Methods: We randomized 12 patients in two groups. Group A (control) received a placebo cream and group B received a 10% phenylephrine cream. The study was prospective, randomized and double-blind., Results: There were no significant differences between the two groups in age, follow-up time since the closure of ileostomy and pre-treatment and intra-treatment leaks. Control group had 7 episodes of incontinence pre-treatment and 9 intra-treatment. Treated group had 3 and 5.4, respectively. (p = NS) No patient had side effects., Conclusions: Given the small number of patients included, we can not yet rule out that topical 10% phenylephrine is useful for the treatment of nocturnal fecal incontinence in patients after ileoanal pouch construction. It would be necessary to continue with studies, increasing the number of patients treated with this drug, in order to have a better evidence of its clinical utility.

Published
2009

21. [Long term functional outcomes after ileoanal pouch in patients with and without postoperative complications].

Author

Gualdrini U, Coraglio M, Filippa L, Masciangioli G, Gutiérrez A, Lumi C, and Graziano A

Subjects
Adolescent, Adult, Aged, Child, Fecal Incontinence etiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Complications, Proctocolectomy, Restorative adverse effects, Treatment Outcome, Colitis, Ulcerative surgery, Colonic Pouches adverse effects, Proctocolectomy, Restorative methods
Abstract

Background: the proctocolectomy with ilealpouch (IP) has become the gold standard for surgical treatment for ulcerative colitis (UC). The postoperative complications are frequent but the definitive outcome is acceptable., Aim: our aim was to evaluate the long term functional outcome in a series of consecutive patients with IP and to establish its relation with postoperative complications., Patients and Methods: we included 144 patients categorized in two groups: I--patients without postoperative complications (n: 71); II--patients with postoperative complications (n: 73). Patients were followed for a median time of 3.8 years (range 1-15). We evaluated: stool frequency, anal discrimination between gas and stool, voluntary evacuation inhibition, requirement of antidiarrheal medications and presence of incontinence., Results: the functional outcome was similar between the two groups in terms of stool fequency medication use, anal discrimination and the voluntary inhibition of evacuation for more than 5 hours. A trend to present seepage was seen in patients with complications (34%) more than in those without them (20%; p<0.08 NS). Compared with group II, seepage in group I was significantly related with dietary lapses (p<0.01). The most frequent complication in incontinent patients was pelvic sepsis (56%)., Conclusions: our study showed that most of long-term functional parameters are not influenced by the presence of postoperative complications. However, a trend for incontinence seems to be related to postoperative complications, more frequently with pelvic sepsis.

Published
2007

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