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1. MYC Rearrangement Prediction From LYSA Whole Slide Images in Large B-Cell Lymphoma: A Multicentric Validation of Self-supervised Deep Learning Models

Author

Syrykh, Charlotte, Di Proietto, Valentina, Brion, Eliott, Copie-Bergman, Christiane, Jardin, Fabrice, Dartigues, Peggy, Gaulard, Philippe, Molina, Thierry Jo, Briere, Josette, Oberic, Lucie, Haioun, Corine, Tilly, Hervé, Maussion, Charles, Morel, Mehdi, Schiratti, Jean-Baptiste, and Laurent, Camille

Published
2024
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2. The alternative RelB NF-κB subunit is a novel critical player in diffuse large B-cell lymphoma

Author

Eluard, Baptiste, Nuan-Aliman, Stéphanie, Faumont, Nathalie, Collares, Davi, Bordereaux, Didier, Montagne, Aurélie, Martins, Isabelle, Cagnard, Nicolas, Caly, Martial, Taoui, Oussama, Lordello, Leonardo, Lehmann-Che, Jacqueline, Tesson, Bruno, Martinez-Climent, Jose-Angel, Copie-Bergman, Christiane, Haioun, Corinne, Tilly, Hervé, Bonsang, Benjamin, Vincent-Salomon, Anne, Jais, Jean-Philippe, Jardin, Fabrice, Leroy, Karen, Maiuri, Maria Chiara, Kroemer, Guido, Molina, Thierry Jo, Feuillard, Jean, and Baud, Véronique

Published
2022
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3. Incidence of central nervous system relapses in patients with DLBCL treated with lenalidomide as maintenance after R-CHOP

Author

Bernard, Sophie, Ghesquieres, Herve, Casasnovas, Rene-Olivier, Griolet, Samuel, Gomes da Silva, Maria, Feugier, Pierre, Morschhauser, Franck, Trotman, Judith, Renaud, Loic, Greil, Richard, García-Sancho, Alejandro Martín, Grosicki, Sebastian, van Eygen, Koen, Copie-Bergman, Christiane, Haioun, Corinne, and Thieblemont, Catherine

Published
2021
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4. The landscape of copy number variations in classical Hodgkin lymphoma: a joint KU Leuven and LYSA study on cell-free DNA

Author

Buedts, Lieselot, Wlodarska, Iwona, Finalet-Ferreiro, Julio, Gheysens, Olivier, Dehaspe, Luc, Tousseyn, Thomas, Fornecker, Luc-Matthieu, Lazarovici, Julien, Casasnovas, René-Olivier, Gac, Anne-Claire, Bonnet, Christophe, Bouabdallah, Kamal, Copie-Bergman, Christiane, Fabiani, Bettina, Dierickx, Daan, Marcelis, Lukas, Vermeesch, Joris, André, Marc, and Vandenberghe, Peter

Published
2021
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5. Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease

Author

Nann, Dominik, Ramis-Zaldivar, Joan Enric, Müller, Inga, Gonzalez-Farre, Blanca, Schmidt, Janine, Egan, Caoimhe, Salmeron-Villalobos, Julia, Clot, Guillem, Mattern, Sven, Otto, Franziska, Mankel, Barbara, Colomer, Dolors, Balagué, Olga, Szablewski, Vanessa, Lome-Maldonado, Carmen, Leoncini, Lorenzo, Dojcinov, Stefan, Chott, Andreas, Copie-Bergman, Christiane, Bonzheim, Irina, Fend, Falko, Jaffe, Elaine S., Campo, Elias, Salaverria, Itziar, and Quintanilla-Martinez, Leticia

Published
2020
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7. GAPDH Expression Predicts the Response to R-CHOP, the Tumor Metabolic Status, and the Response of DLBCL Patients to Metabolic Inhibitors

Author

Chiche, Johanna, Reverso-Meinietti, Julie, Mouchotte, Annabelle, Rubio-Patiño, Camila, Mhaidly, Rana, Villa, Elodie, Bossowski, Jozef P., Proics, Emma, Grima-Reyes, Manuel, Paquet, Agnès, Fragaki, Konstantina, Marchetti, Sandrine, Briere, Josette, Ambrosetti, Damien, Michiels, Jean-François, Molina, Thierry Jo, Copie-Bergman, Christiane, Lehmann-Che, Jacqueline, Peyrottes, Isabelle, Peyrade, Frederic, de Kerviler, Eric, Taillan, Bruno, Garnier, Georges, Verhoeyen, Els, Paquis-Flucklinger, Véronique, Shintu, Laetitia, Delwail, Vincent, Delpech-Debiais, Celine, Delarue, Richard, Bosly, André, Petrella, Tony, Brisou, Gabriel, Nadel, Bertrand, Barbry, Pascal, Mounier, Nicolas, Thieblemont, Catherine, and Ricci, Jean-Ehrland

Published
2019
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8. Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas: A Series of 22 Cases Expanding the Spectrum of Transdifferentiation

Author

Trecourt, Alexis, Mauduit, Claire, Szablewski, Vanessa, Fontaine, Juliette, Balme, Brigitte, Donzel, Marie, Laurent, Camille, Sesques, Pierre, Ghesquières, Hervé, Bachy, Emmanuel, Salles, Gilles, Emile, Jean-François, Chassagne-Clément, Catherine, Genestier, Laurent, Copie-Bergman, Christiane, and Traverse-Glehen, Alexandra

Published
2022
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11. APRIL-producing eosinophils are involved in gastric MALT lymphomagenesis induced by Helicobacter sp infection

Author

Blosse, Alice, Peru, Sara, Levy, Michael, Marteyn, Benoit, Floch, Pauline, Sifré, Elodie, Giese, Alban, Prochazkova-Carlotti, Martine, Azzi Martin, Lamia, Dubus, Pierre, Mégraud, Francis, Ruskone Fournestraux, Agnès, Fabiani, Bettina, Copie Bergman, Christiane, Robe, Cyrielle, Hahne, Michael, Huard, Bertrand, and Lehours, Philippe

Published
2020
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12. Combining gene expression profiling and machine learning to diagnose B-cell non-Hodgkin lymphoma

Author

Bobée, Victor, Drieux, Fanny, Marchand, Vinciane, Sater, Vincent, Veresezan, Liana, Picquenot, Jean-Michel, Viailly, Pierre-Julien, Lanic, Marie-Delphine, Viennot, Mathieu, Bohers, Elodie, Oberic, Lucie, Copie-Bergman, Christiane, Molina, Thierry Jo, Gaulard, Philippe, Haioun, Corinne, Salles, Gilles, Tilly, Hervé, Jardin, Fabrice, and Ruminy, Philippe

Published
2020
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13. Lymphome gastrique du MALT.

Author

Lévy, Michaël and Copie-Bergman, Christiane

Subjects
*MUCOSA-associated lymphoid tissue lymphoma, *ADENOCARCINOMA, *RADIOTHERAPY
Abstract

Low-grade gastric MALT (Mucosa-Associated Lymphoid Tissue) lymphoma is an extranodal marginal zone small B-cell lymphoma frequently associated with a chronic infection by Helicobacter pylori , which can be completely cured with antibiotic treatment. The initial evaluation of the disease's extent should help to determine the predictive factors of the response to the first line of treatment which is eradication of Helicobacter pylori infection. In cases of localized disease in the stomach without peri-gastric lymph nodes involvement on endoscopic ultrasound and especially in the absence of the t(11;18) translocation within the tumor cells, this treatment may be sufficient to obtain a complete remission in 80 to 90% of cases. In cases of Helicobacter pylori-negative MALT lymphoma or if the disease persists despite bacterial eradication, other therapies are available, although there is no consensus. These include a systemic treatment with rituximab, either alone or in combination with chlorambucil, depending on the presence of the t(11;18) translocation, or radiotherapy in the case of localized disease. Long-term endoscopic monitoring is necessary to detect rare cases of late relapse but especially the development of gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Baseline circulating tumour DNA and total metabolic tumour volume as early outcome predictors in aggressive large B‐cell lymphoma. A real‐world 112‐patient cohort

Author

Le Goff, Enora, primary, Blanc‐Durand, Paul, additional, Roulin, Louise, additional, Lafont, Charlotte, additional, Loyaux, Romain, additional, MBoumbae, Diana‐Laure, additional, Benmaad, Ichrafe, additional, Claudel, Alexis, additional, Poullot, Elsa, additional, Robe, Cyrielle, additional, Gricourt, Guillaume, additional, Aissat, Abdelrazak, additional, Copie‐Bergman, Christiane, additional, Lemonnier, François, additional, Gaulard, Philippe, additional, Itti, Emmanuel, additional, Haioun, Corinne, additional, and Delfau‐Larue, Marie‐Helene, additional

Published
2023
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15. Supplementary Data from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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16. Table S5. Cohort variants. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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17. Table S2. Cell of origin according to MYD88 mutations. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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18. Table S7. Immunohistochemical markers and gene rearrangements according to MYD88 variants. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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19. Supplementary Data from Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Mareschal, Sylvain, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Maingonnat, Catherine, primary, Jais, Jean-Philippe, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Molina, Thierry J., primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Brière, Josette, primary, Petrella, Tony, primary, Canioni, Danielle, primary, Fabiani, Bettina, primary, Coiffier, Bertrand, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, Bosly, André, primary, André, Marc, primary, Ketterer, Nicolas, primary, Salles, Gilles, primary, Tilly, Hervé, primary, Leroy, Karen, primary, and Jardin, Fabrice, primary

Published
2023
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20. Table S10. Clinical characteristics of patients with CNS relapse. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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21. Table S1. Clinical and immunohistochemical data according to MYD88 mutation status. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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22. Table S6. Cohort copy number variations. from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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23. Supplementary Figures from Biological and Clinical Relevance of Associated Genomic Alterations in MYD88 L265P and non-L265P–Mutated Diffuse Large B-Cell Lymphoma: Analysis of 361 Cases

Author

Dubois, Sydney, primary, Viailly, Pierre-Julien, primary, Bohers, Elodie, primary, Bertrand, Philippe, primary, Ruminy, Philippe, primary, Marchand, Vinciane, primary, Maingonnat, Catherine, primary, Mareschal, Sylvain, primary, Picquenot, Jean-Michel, primary, Penther, Dominique, primary, Jais, Jean-Philippe, primary, Tesson, Bruno, primary, Peyrouze, Pauline, primary, Figeac, Martin, primary, Desmots, Fabienne, primary, Fest, Thierry, primary, Haioun, Corinne, primary, Lamy, Thierry, primary, Copie-Bergman, Christiane, primary, Fabiani, Bettina, primary, Delarue, Richard, primary, Peyrade, Frédéric, primary, André, Marc, primary, Ketterer, Nicolas, primary, Leroy, Karen, primary, Salles, Gilles, primary, Molina, Thierry J., primary, Tilly, Hervé, primary, and Jardin, Fabrice, primary

Published
2023
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24. Gray-zone Lymphoma Between cHL and Large B-Cell Lymphoma: A Histopathologic Series From the LYSA

Author

Sarkozy, Clémentine, Copie-Bergman, Christiane, Damotte, Diane, Ben-Neriah, Susana, Burroni, Barbara, Cornillon, Jérome, Lemal, Richard, Golfier, Camille, Fabiani, Bettina, Chassagne-Clément, Catherine, Parrens, Marie, Herbaux, Charles, Xerri, Luc, Bossard, Celine, Laurent, Camille, Cheminant, Morgane, Cartron, Guillaume, Cabecadas, Jose, Molina, Thierry, Salles, Gilles, Steidl, Christian, Ghesquières, Hervé, Mottok, Anja, and Traverse-Glehen, Alexandra

Published
2019
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26. MYC-IG rearrangements are negative predictors of survival in DLBCL patients treated with immunochemotherapy: a GELA/LYSA study

Author

Copie-Bergman, Christiane, Cuillière-Dartigues, Peggy, Baia, Maryse, Briere, Josette, Delarue, Richard, Canioni, Danielle, Salles, Gilles, Parrens, Marie, Belhadj, Karim, Fabiani, Bettina, Recher, Christian, Petrella, Tony, Ketterer, Nicolas, Peyrade, Frederic, Haioun, Corinne, Nagel, Inga, Siebert, Reiner, Jardin, Fabrice, Leroy, Karen, Jais, Jean-Philippe, Tilly, Herve, Molina, Thierry Jo, and Gaulard, Philippe

Published
2015
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30. Expression of TFH Markers and Detection of RHOA p.G17V and IDH2 p.R172K/S Mutations in Cutaneous Localizations of Angioimmunoblastic T-Cell Lymphomas

Author

Leclaire Alirkilicarslan, Ariane, Dupuy, Aurélie, Pujals, Anaïs, Parrens, Marie, Vergier, Béatrice, Robson, Alistair, Delfau-Larue, Marie-Hélène, Ingen-Housz-Oro, Saskia, Chosidow, Olivier, Haioun, Corinne, Beylot-Barry, Marie, Merlio, Jean-Philippe, Copie-Bergman, Christiane, Gaulard, Philippe, and Ortonne, Nicolas

Published
2017
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34. Personalized risk prediction for event-free survival at 24 months in patients with diffuse large B-cell lymphoma

Author

Maurer, Matthew J., Jais, Jean-Philippe, Ghesquières, Hervé, Witzig, Thomas E., Hong, Fangxin, Haioun, Corinne, Thompson, Carrie A., Thieblemont, Catherine, Micallef, Ivana N., Porrata, Luis F., Ribrag, Vincent, Nowakowski, Gregorz S., Casasnovas, Olivier, Bologna, Serge, Morschhauser, Franck, Morrison, Vicki A., Peterson, Bruce A., Macon, William R., Copie-Bergman, Christiane, Feldman, Andrew L., Syrbu, Sergei I., Kurtin, Paul J., Gascoyne, Randy D., Li, Hailun, Allmer, Cristine, Kahl, Brad S., Ansell, Stephen M., Slager, Susan L., Link, Brian K., Salles, Gilles, Habermann, Thomas M., Tilly, Hervé, and Cerhan, James R.

Published
2016
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37. Integrative Study of a High-Grade B-Cell Lymphoma Cohort of 45 Patients: A Single Institution Real Life Study

Author

Roulin, Louise, primary, Poullot, Elsa, additional, Blanc-Durand, Paul, additional, Robe, Cyrielle, additional, Lemonnier, Francois, additional, Le Bras, Fabien, additional, Gounot, Romain, additional, Belhadj, Karim, additional, Dupuis, Jehan, additional, Hammoud, Mohammad, additional, El Gnaoui, Taoufik, additional, Mule, Sebastien, additional, Copie Bergman, Christiane, additional, Molina, Thierry, additional, Delfau Larue, Marie Helene, additional, Itti, Emmanuel, additional, Gaulard, Philippe, additional, and Haioun, Corinne, additional

Published
2021
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38. Correction to: Quality of life of survivors 1 year after the diagnosis of diffuse large B-cell lymphoma: a LYSA study

Author

Paunescu, Alexandra‑Cristina, primary, Copie Bergman, Christiane, additional, Malak, Sandra, additional, Le Gouill, Steven, additional, Ribrag, Vincent, additional, Bouabdallah, Krimo, additional, Sibon, David, additional, Rumpold, Gerhard, additional, Preau, Marie, additional, Mounier, Nicolas, additional, Haioun, Corinne, additional, Jardin, Fabrice, additional, and Besson, Caroline, additional

Published
2021
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39. AUGMENT: A Phase III Study of Lenalidomide Plus Rituximab Versus Placebo Plus Rituximab in Relapsed or Refractory Indolent Lymphoma

Author

Leonard, John P, Trneny, Marek, Izutsu, Koji, Fowler, Nathan H, Hong, Xiaonan, Zhu, Jun, Zhang, Huilai, Offner, Fritz, Scheliga, Adriana, Nowakowski, Grzegorz S, Pinto, Antonio, Re, Francesca, Fogliatto, Laura Maria, Scheinberg, Phillip, Flinn, Ian W, Moreira, Claudia, Cabecadas, Jose, Liu, David, Kalambakas, Stacey, Fustier, Pierre, Wu, Chengqing, Gribben, John G, Calaminici, Maria, Copie-Bergman, Christiane, Lopez-Guillermo, Armando, O'Connor, Owen, Williams, Michael, Suciu, Stefan, Levine, Benjamin, and Kern, Julie

Subjects
Male, RECURRENT FOLLICULAR LYMPHOMA, Oncology, Cancer Research, MULTICENTER, Lymphoma, Mantle-Cell, GUIDELINES, Placebos, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Medicine and Health Sciences, Lymphoma, Follicular, Lenalidomide, Monoclonal antibody therapy, NATURAL-KILLER-CELL, Aged, 80 and over, Lymphoma, Non-Hodgkin, Recurrent Follicular Lymphoma, ORIGINAL REPORTS, Middle Aged, OPEN-LABEL, 030220 oncology & carcinogenesis, SURVIVAL, Female, TRIAL, Rituximab, medicine.drug, Adult, Bendamustine, medicine.medical_specialty, MONOCLONAL-ANTIBODY THERAPY, Placebo, 03 medical and health sciences, Refractory, Internal medicine, Hematologic Malignancy, medicine, Humans, Aged, business.industry, Lymphoma, B-Cell, Marginal Zone, medicine.disease, Lymphoma, MAINTENANCE, BENDAMUSTINE, Neoplasm Recurrence, Local, business, 030215 immunology
Abstract

PURPOSE Patients with indolent non-Hodgkin lymphoma typically respond well to first-line immunochemotherapy. At relapse, single-agent rituximab is commonly administered. Data suggest the immunomodulatory agent lenalidomide could increase the activity of rituximab. METHODS A phase III, multicenter, randomized trial of lenalidomide plus rituximab versus placebo plus rituximab was conducted in patients with relapsed and/or refractory follicular or marginal zone lymphoma. Patients received lenalidomide or placebo for 12 cycles plus rituximab once per week for 4 weeks in cycle 1 and day 1 of cycles 2 through 5. The primary end point was progression-free survival per independent radiology review. RESULTS A total of 358 patients were randomly assigned to lenalidomide plus rituximab (n = 178) or placebo plus rituximab (n = 180). Infections (63% v 49%), neutropenia (58% v 23%), and cutaneous reactions (32% v 12%) were more common with lenalidomide plus rituximab. Grade 3 or 4 neutropenia (50% v 13%) and leukopenia (7% v 2%) were higher with lenalidomide plus rituximab; no other grade 3 or 4 adverse event differed by 5% or more between groups. Progression-free survival was significantly improved for lenalidomide plus rituximab versus placebo plus rituximab, with a hazard ratio of 0.46 (95% CI, 0.34 to 0.62; P < .001) and median duration of 39.4 months (95% CI, 22.9 months to not reached) versus 14.1 months (95% CI, 11.4 to 16.7 months), respectively. CONCLUSION Lenalidomide improved efficacy of rituximab in patients with recurrent indolent lymphoma, with an acceptable safety profile.

Published
2019

40. High-grade Follicular Lymphomas Exhibit Clinicopathologic, Cytogenetic, and Molecular Diversity Extending Beyond Grades 3A and 3B

Author

Laurent, Camille, primary, Adélaïde, José, additional, Guille, Arnaud, additional, Tesson, Bruno, additional, Gat, Elodie, additional, Evrard, Solene, additional, Escudié, Frederic, additional, Syrykh, Charlotte, additional, Canioni, Danielle, additional, Fabiani, Bettina, additional, Meignin, Véronique, additional, Chassagne-Clement, Catherine, additional, Dartigues, Peggy, additional, Traverse-Glehen, Alexandra, additional, Parrens, Marie, additional, Huet, Sarah, additional, Copie-Bergman, Christiane, additional, Salles, Gilles, additional, Birnbaum, Daniel, additional, Brousset, Pierre, additional, Morschhauser, Franck, additional, and Xerri, Luc, additional

Published
2021
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41. Plasticity of Mature B Cells Between Follicular and Classic Hodgkin Lymphomas

Author

Trecourt, Alexis, primary, Mauduit, Claire, additional, Szablewski, Vanessa, additional, Fontaine, Juliette, additional, Balme, Brigitte, additional, Donzel, Marie, additional, Laurent, Camille, additional, Sesques, Pierre, additional, Ghesquières, Hervé, additional, Bachy, Emmanuel, additional, Salles, Gilles, additional, Emile, Jean-François, additional, Chassagne-Clément, Catherine, additional, Genestier, Laurent, additional, Copie-Bergman, Christiane, additional, and Traverse-Glehen, Alexandra, additional

Published
2021
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42. Genetic Characterization and Clinical Features of Helicobacter pylori Negative Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Author

Kiesewetter, Barbara, primary, Copie-Bergman, Christiane, additional, Levy, Michael, additional, Wu, Fangtian, additional, Dupuis, Jehan, additional, Barau, Caroline, additional, Arcaini, Luca, additional, Paulli, Marco, additional, Lucioni, Marco, additional, Bonometti, Arturo, additional, Salar, Antonio, additional, Fernández-Rodriguez, Concepción, additional, Piris, Miguel A., additional, Cucco, Francesco, additional, Dobson, Rachel, additional, Li, Yan, additional, Chen, Zi, additional, Robe, Cyrielle, additional, Simonitsch-Klupp, Ingrid, additional, Wotherspoon, Andrew, additional, Raderer, Markus, additional, and Du, Ming Qing, additional

Published
2021
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43. The landscape of copy number variations in classical Hodgkin lymphoma: a joint KU Leuven and LYSA study on cell-free DNA.

Author

UCL - (MGD) Service d'hématologie, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Buedts, Lieselot, Wlodarska, Iwona, Finalet-Ferreiro, Julio, Gheysens, Olivier, Dehaspe, Luc, Tousseyn, Thomas, Fornecker, Luc-Matthieu, Lazarovici, Julien, Casasnovas, René-Olivier, Gac, Anne-Claire, Bonnet, Christophe, Bouabdallah, Kamal, Copie-Bergman, Christiane, Fabiani, Bettina, Dierickx, Daan, Marcelis, Lukas, Vermeesch, Joris, André, Marc, Vandenberghe, Peter, UCL - (MGD) Service d'hématologie, UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, Buedts, Lieselot, Wlodarska, Iwona, Finalet-Ferreiro, Julio, Gheysens, Olivier, Dehaspe, Luc, Tousseyn, Thomas, Fornecker, Luc-Matthieu, Lazarovici, Julien, Casasnovas, René-Olivier, Gac, Anne-Claire, Bonnet, Christophe, Bouabdallah, Kamal, Copie-Bergman, Christiane, Fabiani, Bettina, Dierickx, Daan, Marcelis, Lukas, Vermeesch, Joris, André, Marc, and Vandenberghe, Peter

Abstract

The low abundance of Hodgkin/Reed-Sternberg (HRS) cells in lymph node biopsies in classical Hodgkin lymphoma (cHL) complicates the analysis of somatic genetic alterations in HRS cells. As circulating cell-free DNA (cfDNA) contains circulating tumor DNA (ctDNA) from HRS cells, we prospectively collected cfDNA from 177 patients with newly diagnosed, mostly early-stage cHL in a monocentric study at Leuven, Belgium (n = 59) and the multicentric BREACH study by Lymphoma Study Association (n = 118). To catalog the patterns and frequencies of genomic copy number aberrations (CNAs), cfDNA was sequenced at low coverage (0.26×), and data were analyzed with ichorCNA to yield read depth-based copy number profiles and estimated clonal fractions in cfDNA. At diagnosis, the cfDNA concentration, estimated clonal fraction, and ctDNA concentration were significantly higher in cHL cases than controls. More than 90% of patients exhibited CNAs in cfDNA. The most frequent gains encompassed 2p16 (69%), 5p14 (50%), 12q13 (50%), 9p24 (50%), 5q (44%), 17q (43%), 2q (41%). Losses mostly affected 13q (57%), 6q25-q27 (55%), 4q35 (50%), 11q23 (44%), 8p21 (43%). In addition, we identified loss of 3p13-p26 and of 12q21-q24 and gain of 15q21-q26 as novel recurrent CNAs in cHL. At diagnosis, ctDNA concentration was associated with advanced disease, male sex, extensive nodal disease, elevated erythrocyte sedimentation rate, metabolic tumor volume, and HRS cell burden. CNAs and ctDNA rapidly diminished upon treatment initiation, and persistence of CNAs was associated with increased probability of relapse. This study endorses the development of ctDNA as gateway to the HRS genome and substrate for early disease response evaluation.

Published
2021

44. c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study

Author

Faumont, Nathalie, Taoui, Oussama, Collares, Davi, Jais, Jean-Philippe, Leroy, Karen, Prévaud, Léa, Jardin, Fabrice, Molina, Thierry, Copie-Bergman, Christiane, Petit, Barbara, Gourin, Marie-Pierre, Bordessoule, Dominique, Troutaud, Danielle, Baud, Véronique, Feuillard, Jean, Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques (GPMCND), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Limoges, Service d'Hématologie clinique et thérapie cellulaire [CHU Limoges], Contrôle de l’Activation Cellulaire, Progression Tumorale et Résistance thérapeutique (CAPTuR), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)

Subjects
c-Rel, germinal center B-cell–diffuse large B-cell lymphoma, animal structures, genetic alterations, Oncology, [SDV]Life Sciences [q-bio], hemic and lymphatic diseases, embryonic structures, NF-kappaB, DNA binding activity, Original Research
Abstract

International audience; Relationships between c-Rel and GCB-DLBCLs remain unclear. We found that strong c-Rel DNA-binding activity was mostly found in GCBs on two independent series of 48 DLBCLs and 66 DLBCLs, the latter issued from the GHEDI series. c-Rel DNA-binding activity was associated with increased REL mRNA expression. Extending the study to the whole GHEDI and Lenz DLBCL published series of 202 and 233 cases, it was found that the c-Rel gene expression profile (GEP) overlapped partially (12%) but only with the GCB GEP and not with the GEP of ABC-DLBCLs. Cases with both overexpression of REL mRNA and c-Rel GEP were defined as those having a c-Rel signature. These cases were GCBs in 88 and 83% of the GHEDI or Lenz's DLBCL series respectively. The c-Rel signature was also associated with various recurrent GCB-DLBCL genetic events, including REL gains, BCL2 translocation, MEF2B, EZH2, CREBBP, and TNFRSF14 mutations and with the EZB GCB genetic subtype. By CGH array, the c-Rel signature was specifically correlated with 2p15-16.1 amplification that includes XPO1, BCL11A, and USP34 and with the 22q11.22 deletion that covers IGLL5 and PRAME. The total number of gene copy number aberrations, so-called genomic imbalance complexity, was decreased in cases with the c-Rel signature. These cases exhibited a better overall survival. Functionally, overexpression of c-Rel induced its constitutive nuclear localization and protected cells against apoptosis while its repression tended to increase cell death. These results show that, clinically and biologically, c-Rel is the pivotal NF-κB subunit in the GCB-DLBCL subgroup. Functionally, c-Rel overexpression could directly promote DLBCL tumorigenesis without need for further activation signals.

Published
2020

47. Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach

Author

van Rijk, Anke, Mason, David, Jones, Margaret, Cabeçadas, José, Crespo, Mateus, Cigudosa, Juan Cruz, Garcia, Juan Fernando, Leoncini, Lorenzo, Cocco, Mario, Hansmann, Martin-Leo, Mottok, Anja, Copie Bergman, Christiane, Baia, Maryse, Anagnostou, Dimitra, Pouliou, Evi, Hamilton Dutoit, Stephen, Hjøllund Christiansen, Mette, Svenstrup Poulsen, Tim, Hauge Matthiesen, Steen, van Dongen, Jacques, and van Krieken, J. Han

Published
2008
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48. c-Rel Is the Pivotal NF-κB Subunit in Germinal Center Diffuse Large B-Cell Lymphoma: A LYSA Study

Author

Faumont, Nathalie, primary, Taoui, Oussama, additional, Collares, Davi, additional, Jais, Jean-Philippe, additional, Leroy, Karen, additional, Prévaud, Léa, additional, Jardin, Fabrice, additional, Molina, Thierry J., additional, Copie-Bergman, Christiane, additional, Petit, Barbara, additional, Gourin, Marie-Pierre, additional, Bordessoule, Dominique, additional, Troutaud, Danielle, additional, Baud, Véronique, additional, and Feuillard, Jean, additional

Published
2021
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