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2. The impact of metallic nanoparticles on gut fermentation processes: An integrated metabolomics and metagenomics approach following an in vitro digestion and fecal fermentation model

Author

Vaccari, Filippo, Zhang, Leilei, Giuberti, Gianluca, Grasso, A., Bandini, Francesca, García-Pérez, P., Copat, C., Lucini, Luigi, Dall'Asta, Margherita, Ferrante, M., Puglisi, Edoardo, Vaccari F., Zhang L., Giuberti G. (ORCID:0000-0002-0135-1609), Bandini F. (ORCID:0000-0002-8926-7275), Lucini L. (ORCID:0000-0002-5133-9464), Dall'Asta M. (ORCID:0000-0002-0558-0337), Puglisi E. (ORCID:0000-0001-5051-0971), Vaccari, Filippo, Zhang, Leilei, Giuberti, Gianluca, Grasso, A., Bandini, Francesca, García-Pérez, P., Copat, C., Lucini, Luigi, Dall'Asta, Margherita, Ferrante, M., Puglisi, Edoardo, Vaccari F., Zhang L., Giuberti G. (ORCID:0000-0002-0135-1609), Bandini F. (ORCID:0000-0002-8926-7275), Lucini L. (ORCID:0000-0002-5133-9464), Dall'Asta M. (ORCID:0000-0002-0558-0337), and Puglisi E. (ORCID:0000-0001-5051-0971)

Abstract

Metallic nanoparticles (MNPs) are becoming widespread environmental contaminants. They are currently added to several food preparations and cause a fast-growing concern for human health. The present work aims to assess the impact of zinc oxide (ZnO), titanium dioxide (TiO2), and silver (Ag) nanoparticles (NPs) on the human gut metabolome and microbiome. Water samples spiked with two different concentrations of each MNPs were subjected to in-vitro gastrointestinal digestion and in-vitro large intestine fermentation. The effects of the treatments were determined through 16 S amplicon sequencing and untargeted metabolomics. Multi-omics data integration was then applied to correlate the two datasets. MNPs treatments modulated the microbial genera Bifidobacterium, Sutterella, Escherichia and Bacteroides. The treatments, especially the lower concentrations of Ag and ZnO, caused modulation of indole derivatives, peptides, and metabolites related to protein metabolism in the large intestine. Notably, these metabolites are implicated in ulcerative colitis and inflammatory bowel disease. TiO2 NPs treatment in all concentrations increased E.coli relative abundance and decreased the abundance of B. longum. Moreover, for TiO2, an enrichment in proinflammatory lipid mediators of arachidonic acid metabo-lites, such as prostaglandin E2 and leukotrienes B4, was detected. For all metals except TiO2, low NP concen-trations promoted differentiated profiles, thus suggesting that MNPs aggregation can limit adverse effects on living cells.

Published
2023

3. Behaviour and fate of Ag-NPs, TiO2-NPs and ZnO-NPs in the human gastrointestinal tract: Biopersistence rate evaluation

Author

Ferrante, M., Grasso, A., Giuberti, Gianluca, Dall'Asta, Margherita, Puglisi, Edoardo, Arena, G., Nicosia, A., Fiore, M., Copat, C., Giuberti G. (ORCID:0000-0002-0135-1609), Dall'Asta M. (ORCID:0000-0002-0558-0337), Puglisi E. (ORCID:0000-0001-5051-0971), Ferrante, M., Grasso, A., Giuberti, Gianluca, Dall'Asta, Margherita, Puglisi, Edoardo, Arena, G., Nicosia, A., Fiore, M., Copat, C., Giuberti G. (ORCID:0000-0002-0135-1609), Dall'Asta M. (ORCID:0000-0002-0558-0337), and Puglisi E. (ORCID:0000-0001-5051-0971)

Abstract

This study aims to provide information on the behaviour and biopersistence rate (BP) of metallic nanoparticles (Ag-NPs, TiO2-NPs, ZnO-NPs) naturally occurring in canned seafood and subjected to static in vitro digestion. Single particle ICP-MS analysis was performed to determine NPs distribution and concentrations in oral, gastric, and intestinal digests. Depending on the conditions of the digestive phase and the sample matrix, the phenomena of agglomeration and dispersion were highlighted and confirmed by Dynamic Light Scattering (DLS) technique. In standard suspensions, Ag-NPs had lower biopersistence (BP) than ZnO and TiO2-NPs (BP 34%, 89% and >100%, respectively). Among Ag-NPs and TiO2-NPs naturally present in the food matrix, those in canned tuna were more degradable than those in canned clam (BP Ag-NPs 36% vs. > 100%; BP TiO2-NPs 96% vs. > 100%), while BP ZnO-NPs showed high biopersistence in both seafood matrix (>100%). The biopersistence rates were higher than the recommended limit set by European Food Safety Authority (EFSA) (12%), referred to nanotechnologies to be applied in the food and feed chain, thus the investigated naturally occurring NPs cannot be considered readily degradable.

Published
2023

12. Impact of the environment on the health: From theory to practice

Author

Carducci, A.L., primary, Agodi, A., additional, Ancona, C., additional, Angelini, P., additional, Bagordo, F., additional, Barbone, F., additional, Birbaum, L., additional, Carreri, V., additional, Casuccio, A., additional, Conti, A., additional, Conversano, M., additional, De Donno, A., additional, De Giglio, O., additional, Desiante, F., additional, Di Pietro, A., additional, Dogliotti, E., additional, Donato, F., additional, Fara, G.M., additional, Fiore, M., additional, Forastiere, F., additional, Giammanco, G., additional, Izzotti, A., additional, Montagna, M.T., additional, Oliveri Conti, G., additional, Petronio, M.G., additional, Sciacca, S., additional, Signorelli, C., additional, Testai, E., additional, Verani, M., additional, Vinceti, M., additional, Vitale, F., additional, Ferrante, M., additional, Adani, G., additional, Berghella, L., additional, Calia, C., additional, Calzolari, R., additional, Canale, A., additional, Castiglione, D., additional, Copat, C., additional, Cristaldi, A., additional, Cuffari, G., additional, Coronel Vargas, G., additional, De Vita, E., additional, De Nard, F., additional, Federigi, I., additional, Filippini, T., additional, Grasso, A., additional, Leonardi, N., additional, Letzgus, M., additional, Lo Bianco, G., additional, Mazzucco, W., additional, Nicolosi, I., additional, Orlandi, P., additional, Paladino, G., additional, Pizzo, S., additional, Pousis, C., additional, Raffo, M., additional, Rivolta, S., additional, Scarpitta, F., additional, Trani, G., additional, Triggiano, F., additional, Tumbarello, A., additional, Vecchio, V., additional, Zuccarello, P., additional, and Vassallo, M., additional

Published
2021
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15. Water quality and human health: A simple monitoring model of toxic cyanobacteria growth in highly variable Mediterranean hot dry environments

Author

Zuccarello, P., primary, Manganelli, M., additional, Oliveri Conti, G., additional, Copat, C., additional, Grasso, A., additional, Cristaldi, A., additional, De Angelis, G., additional, Testai, E., additional, Stefanelli, M., additional, Vichi, S., additional, Fiore, M., additional, and Ferrante, M., additional

Published
2021
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22. Strategies for Disease Prevention and Health Promotion in Urban Areas: The Erice 50 Charter

Author

D'Alessandro, D, Arletti, S, Azara, A, Buffoli, M, Capasso, L, Cappuccitti, A, Casuccio, A, Cecchini, A, Costa, G, De Martino, A M, Dettori, M, Di Rosa, E, Fara, G M, Ferrante, M, Giammanco, G, Lauria, A, Melis, G, Moscato, U, Oberti, I, Patrizio, C, Petronio, M G, Rebecchi, A, ROMANO SPICA, Vincenzo, Settimo, G, Signorelli, C, Capolongo, S, Attendees of the 50th Course Urban Health, Alessi, V, Apollonio, F, Barbagallo, E, Bassot, Am, Bernini, D, Borghini, A, Borri, M, Brandimarte, A, Copat, C, Cracchiolo, M, Cribellati, S, Cristaldi, A, D'Agati, P, D'Amico, A, De Marchis, A, Dell'Ovo, M, Donia, Am, Filippini, T, Giannetti, G, Giorgi, S, Gola, M, Grasso, A, Graziano, G, Lanzilotti, C, Laudani, N, Lopuzzo, M, Malfer, M, Marchese, V, Marzella, A, Mascarello, A, Milicia, Gm, Nurchis, P, Ogana, S, Oliveri Conti CG, Pacifico, C, Paduano, S, Paglione, L, Palmeri, S, Pieve, G, Raffo, M, Raguzzoni, G, Raia, Dd, Righi, A, Rochira, Andrea, Rondinelli, L, Salvia, C, Sciaraffa, R, Trogu, F, Ubiali, A, Valt, R, Vantaggiato, V, Ventura, G, Zuccarello, P, D'Alessandro, D, Arletti, S, Azara, A, Buffoli, M, Capasso, L, Cappuccitti, A, Casuccio, A, Cecchini, A, Costa, G, De Martino, A M, Dettori, M, Di Rosa, E, Fara, G M, Ferrante, M, Giammanco, G, Lauria, A, Melis, G, Moscato, U, Oberti, I, Patrizio, C, Petronio, M G, Rebecchi, A, Romano Spica, V, Settimo, G, Signorelli, C, Capolongo, S, D'Alessandro, D., Arletti, S., Azara, A., Buffoli, M., Capasso, L., Cappuccitti, A., Casuccio, A., Cecchini, A., Costa, G., De Martino, A. M., Dettori, M., Di Rosa, E., Fara, G. M., Ferrante, M., Giammanco, G., Lauria, A., Melis, G., Moscato, U., Oberti, I., Patrizio, C., Petronio, M. G., Rebecchi, A., Romano Spica, V., Settimo, G., Signorelli, C., Capolongo, S., Alessi, V., Apollonio, F., Barbagallo, E., Bassot, A. M., Bernini, D., Borghini, A., Borri, M., Brandimarte, A., Copat, C., Cracchiolo, M., Cribellati, S., Cristaldi, A., D'Agati, P., D'Amico, A., De Marchis, A., Dell'Ovo, M., Donia, A. M., Filippini, T., Giannetti, G., Giorgi, S., Gola, M., Grasso, A., Graziano, G., Lanzilotti, C., Laudani, N., Lopuzzo, M., Malfer, M., Marchese, V., Marzella, A., Mascarello, A., Milicia, G. M., Nurchis, P., Ogana, S., Oliveri Conti, C. G., Pacifico, C., Paduano, S., Paglione, L., Palmeri, S., Pieve, G., Raffo, M., Raguzzoni, G., Raia, D. D., Righi, A., Rochira, A., Rondinelli, L., Salvia, C., Sciaraffa, R., Trogu, F., Ubiali, A., Valt, R., Vantaggiato, V., Ventura, G., and Zuccarello, P.

Subjects
Planning and Designing Strategies, Urban Health, Health Promotion, Urban Health, Public Health, Built Environment, Planning and Designing Strategies, Health Promotion, Primary Prevention, Italy, Planning and Designing Strategie, built environment, health promotion, planning and designing strategies, public health, urban health, public health environmental and occupational health, infectious diseases, Humans, Public Health, Built Environment, Health promotion
Abstract

The Erice 50 Charter titled "Strategies for Diseases Prevention and Health Promotion in Urban Areas" was unanimously approved at the conclusion of the 50th Residential Course "Urban Health. Instruments for promoting health and for assessing hygienic and sanitary conditions in urban areas", held from 29th March to 2nd April 2017 in Erice, at the "Ettore Majorana" Foundation and Centre for Scientific Culture and promoted by the International School of Epidemiology and Preventive Medicine "G. D'Alessandro" and the Study Group "Building Hygiene" of the Italian Society of Hygiene, Preventive Medicine and Public Health (SItI). At the conclusion of the intense learning experience during the Course, with more than 20 lectures, workshops and long-lasting discussions between Professors and Students, the participants identified the major points connecting urban features and Public Health, claiming the pivotal role of urban planning strategies for the management of Diseases Prevention and Health Promotion activities. The Erice 50 Charter is configured as a Decalogue for Healthy Cities and as a Think Tank for designing effective strategic actions and best practices to develop urban regeneration interventions and improve the urban quality of contemporary cities. The Decalogue is structured into the following key strategic objectives: 1. Promoting urban planning interventions that address citizens towards healthy behaviours; 2. Improving living conditions in the urban context; 3. Building an accessible and inclusive city, with a special focus on the frail population; 4. Encouraging the foundation of resilient urban areas; 5. Supporting the development of new economies and employment through urban renewal interventions; 6. Tackling social inequalities; 7. Improving stakeholders' awareness of the factors affecting Public Health in the cities; 8. Ensuring a participated urban governance; 9. Introducing qualitative and quantitative performance tools, capable of measuring the city's attitude to promote healthy lifestyles and to monitor the population's health status; 10. Encouraging sharing of knowledge and accessibility to informations. Finally, all the participants underlined that a multidisciplinary team, composed of Physicians specialized in Hygiene, Preventive Medicine, Public Health and Technicians as Architects, Urban planners and Engineers, is needed to deepen the research topic of Urban Health.

Published
2017

46. BISMUTH (Bi)

Author

Mauceri, C and Copat, C

Published
2014

47. COBALT (Co)

Author

Floridia, A and Copat, C.

Published
2014

48. Gestione delle risorse idriche in italia

Author

Aggazzotti, Gabriella, Agodi, A, Carreri, V, Conversano, M, De Donno, A, Fallico, R, Faggioli, A, Ferrante, M, Francia, F, Monarca, S, Petronio, Mg, Sciacca, S, Signorelli, C, Vinceti, Marco, Olivieri Conti, G, Mauceri, C, Dimartino, A, Fiore, M, Ledda, C, Copat, C, Grasso, A, and Cafarella, N.

Subjects
risorse idriche, Italia, salute
Published
2013

50. Gestione delle Risorse Idriche in Italia

Author

Agazzotti, G, Agodi, ANTONELLA PAOLA, Carreri, V, Conversano, M, De Donno, A, Fallico, R, Faggioli, A, Ferrante, Margherita, Francia, F, Monarca, S, Petronio, Mg, Sciacca, S, Signorelli, C, Vinceti, M, Oliveri Conti, G, Mauceri, C, Dimartino, A, Fiore, Maria, Ledda, C, Copat, C, Grasso, A, and Cafarella, N.

Published
2013

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