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4. Data from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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5. Supplementary Table 4 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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6. Supplementary Figure 2 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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7. Supplementary Table 3 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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8. Supplementary Table 1 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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9. Supplementary Table 5 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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10. Supplementary Table 6 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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11. Supplementary Table 2 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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12. Supplementary Figure 1 from Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Author

Paolino, Jonathan, primary, Dimitrov, Boris, primary, Apsel Winger, Beth, primary, Sandoval-Perez, Angelica, primary, Rangarajan, Amith Vikram, primary, Ocasio-Martinez, Nicole, primary, Tsai, Harrison K., primary, Li, Yuting, primary, Robichaud, Amanda L., primary, Khalid, Delan, primary, Hatton, Charlie, primary, Gillani, Riaz, primary, Polonen, Petri, primary, Dilig, Anthony, primary, Gotti, Giacomo, primary, Kavanagh, Julia, primary, Adhav, Asmani A., primary, Gow, Sean, primary, Tsai, Jonathan, primary, Li, Yen Der, primary, Ebert, Benjamin L., primary, Van Allen, Eliezer M., primary, Bledsoe, Jacob, primary, Kim, Annette S., primary, Tasian, Sarah K., primary, Cooper, Stacy L., primary, Cooper, Todd M., primary, Hijiya, Nobuko, primary, Sulis, Maria Luisa, primary, Shukla, Neerav N., primary, Magee, Jeffrey A., primary, Mullighan, Charles G., primary, Burke, Michael J., primary, Luskin, Marlise R., primary, Mar, Brenton G., primary, Jacobson, Matthew P., primary, Harris, Marian H., primary, Stegmaier, Kimberly, primary, Place, Andrew E., primary, and Pikman, Yana, primary

Published
2023
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13. Integration of genomic sequencing drives therapeutic targeting of PDGFRA in T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma.

Author

Paolino, Jonathan, primary, Dimitrov, Boris, additional, Apsel Winger, Beth, additional, Sandoval-Perez, Angelica, additional, Rangarajan, Amith Vikram., additional, Ocasio-Martinez, Nicole, additional, Tsai, Harrison K., additional, Li, Yuting, additional, Robichaud, Amanda L., additional, Khalid, Delan, additional, Hatton, Charlie, additional, Gillani, Riaz, additional, Polonen, Petri, additional, Dilig, Anthony, additional, Gotti, Giacomo, additional, Kavanagh, Julia, additional, Adhav, Asmani A., additional, Gow, Sean, additional, Tsai, Jonathan, additional, Li, Yen Der, additional, Ebert, Benjamin L., additional, Van Allen, Eliezer M., additional, Bledsoe, Jacob, additional, Kim, Annette S., additional, Tasian, Sarah K., additional, Cooper, Stacy L., additional, Cooper, Todd M., additional, Hijiya, Nobuko, additional, Sulis, Maria Luisa, additional, Shukla, Neerav N., additional, Magee, Jeffrey A., additional, Mullighan, Charles G., additional, Burke, Michael J., additional, Luskin, Marlise R., additional, Mar, Brenton G., additional, Jacobson, Matthew P., additional, Harris, Marian H., additional, Stegmaier, Kimberly, additional, Place, Andrew E., additional, and Pikman, Yana, additional

Published
2023
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16. CAR T-cell therapy in pediatrics

Author

Percy, Andrew G., Cooper, Stacy L., and Arwood, Nicole M.

Subjects
T cells -- Receptors -- Physiological aspects -- Genetic aspects, Antigen receptors, T cell -- Physiological aspects -- Genetic aspects, Non-Hodgkin's lymphomas -- Diagnosis -- Care and treatment, Health, Health care industry
Abstract

Recent developments in chimeric antigen receptor (CAR) T-cell therapy have shown promise in treating relapsed B-cell acute lymphoblastic leukemia in children. Leukemia is the most common malignancy in children, representing [...]

Published
2019

18. Trainee-led Engagement of the Care Team Improves Application of an Institutional Blood Culture Clinical Decision Algorithm to Pediatric Oncology Inpatients: A Single-institution Quality Improvement Project

Author

Lemberg, Kathryn M., primary, Koontz, Danielle W., additional, Young, David J., additional, DiDomizio, P. Galen, additional, King, Anne, additional, Chen, Allen R., additional, Gamper, Christopher J., additional, Colantuoni, Elizabeth, additional, Milstone, Aaron M., additional, and Cooper, Stacy L., additional

Published
2022
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19. Considerations in Methods and Timing for Delivery of Genetic Counseling Information to Pediatric Oncology Patients and Families

Author

Li, Kathleen A., primary, Sloat, Lauren M., additional, Kung, Julia, additional, Jung, Jessica, additional, Li, Ashley, additional, Smith, Christy H., additional, Schratz, Kristen E., additional, Cooper, Stacy L., additional, Pratilas, Christine A., additional, Frankenfield, Pamela, additional, and Bodurtha, Joann, additional

Published
2021
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21. Research and Care Networks in Acute Leukemia As a Model for Global Healthcare Collaboration

Author

Guscott, Martin R, primary, Cooper, Stacy L, additional, Bagai, Poonam, additional, Bleyer, Archie, additional, Buddington, Randal K, additional, Douer, Dan, additional, Chong, Tina B, additional, Combs, Ryan R, additional, Hylton, Jennifer L, additional, Ines-Villanueva, Gabriela, additional, Lowe, Jennifer A, additional, Pandey, Rishabh, additional, Patel, Aman N, additional, and Howard, Scott C, additional

Published
2021
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28. Improving Detection of Cancer Predisposition Syndromes in Pediatric Oncology

Author

Knoll, Jasmine, Li, Ashley, Smith, Christy H., Schratz, Kristin E., Cooper, Stacy L., Meah, Tarek, Helmke, Elizabeth, Pratilas, Christine A., and Bodurtha, Joann

Abstract

Supplemental Digital Content is available in the text.Implementation and adherence to consensus statement criteria for referral of pediatric cancer patients for genetic evaluation are critical to identify the 5% to 10% with a genetic cancer predisposition syndrome. The authors implemented a Plan-Do-Study-Act quality improvement initiative aimed at increasing referrals of at-risk patients. Retrospective chart review was followed by educational intervention—with impact assessed over a 9-month prospective chart review. Referral rate improved >2-fold and there was an improvement in documented oncologic history to at least a third-degree relative. The integration of quality improvement can be an effective tool to improve the referral of patients with an elevated risk for a cancer predisposition syndrome.

Published
2024
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31. Addressing Schooling in Children With Cancer—It's Everybody's Job, So It's Nobody's Job: An Explanatory Mixed-Methods Evaluation

Author

Thornton, Clifton P., Henegan, Sydney, Carey, Lisa B., Milla, Kim, Cork, Katrina, Cooper, Stacy L., Jacobson, Lisa A., Ruble, Kathy, and Paré-Blagoev, E. Juliana

Abstract

Background:Neurocognitive deficits from childhood cancer treatment are common, long-standing, and negatively impact multiple domains of life leading to challenges with schooling and education. The purpose of this study is to describe caregiver-reported experiences of neurocognitive effects from therapy and to understand the roles clinicians play in this domain in the United States. Methods:An explanatory mixed-methods study of 174 caregivers of children with cancer provided insight into how clinicians provided information on neurocognitive effects of treatment and their experiences with school-related resources. Clinicians provided descriptions of how they provide this information and assist families with accessing services or transition back to school after therapy. Results:Caregivers identified that physicians, nurses, and social workers primarily provide information regarding neurocognitive effects of treatment. Over half (55.9%) of families seek additional information elsewhere and 49.4% report doing so because the information they received from their team was inadequate. Nearly 40% of caregivers report accessing school supports feels like a constant fight and over 40% were not offered homebound educational services by their school. Qualitative interviews with providers found that clinicians focus on therapy-related physical symptoms of treatment and only discuss neurocognitive effects when prompted by families or when children are returning to school. Discussion:Clinicians’ focus on physical symptoms and just-in-time thinking when it comes to providing education or school-related services may explain why families endorse infrequent education on the topic and challenges with school reintegration. Improved education for clinicians on this topic, integration of interdisciplinary teams, and new clinical practice models may improve the family experience.

Published
2022
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