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19 results on '"Cook, Ryan D."'

2. Urban Snowpack ClNO2 Production and Fate: A One-Dimensional Modeling Study

Author

Wang, Siyuan, primary, McNamara, Stephen M., additional, Kolesar, Katheryn R., additional, May, Nathaniel W., additional, Fuentes, Jose D., additional, Cook, Ryan D., additional, Gunsch, Matthew J., additional, Mattson, Claire N., additional, Hornbrook, Rebecca S., additional, Apel, Eric C., additional, and Pratt, Kerri A., additional

Published
2020
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3. Observation of Road Salt Aerosol Driving Inland Wintertime Atmospheric Chlorine Chemistry

Author

McNamara, Stephen M., primary, Kolesar, Katheryn R., additional, Wang, Siyuan, additional, Kirpes, Rachel M., additional, May, Nathaniel W., additional, Gunsch, Matthew J., additional, Cook, Ryan D., additional, Fuentes, Jose D., additional, Hornbrook, Rebecca S., additional, Apel, Eric C., additional, China, Swarup, additional, Laskin, Alexander, additional, and Pratt, Kerri A., additional

Published
2020
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4. Bouncier Particles at Night: Biogenic Secondary Organic Aerosol Chemistry and Sulfate Drive Diel Variations in the Aerosol Phase in a Mixed Forest

Author

Slade, Jonathan H., primary, Ault, Andrew P., additional, Bui, Alexander T., additional, Ditto, Jenna C., additional, Lei, Ziying, additional, Bondy, Amy L., additional, Olson, Nicole E., additional, Cook, Ryan D., additional, Desrochers, Sarah J., additional, Harvey, Rebecca M., additional, Erickson, Matthew H., additional, Wallace, Henry W., additional, Alvarez, Sergio L., additional, Flynn, James H., additional, Boor, Brandon E., additional, Petrucci, Giuseppe A., additional, Gentner, Drew R., additional, Griffin, Robert J., additional, and Shepson, Paul B., additional

Published
2019
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8. Supplementary material to "Biogenic, urban, and wildfire influences on the molecular composition of dissolved organic compounds in cloud water"

Author

Cook, Ryan D., primary, Lin, Ying-Hsuan, additional, Peng, Zhuoyu, additional, Boone, Eric, additional, Chu, Rosalie K., additional, Dukett, James E., additional, Gunsch, Matthew J., additional, Zhang, Wuliang, additional, Tolic, Nikola, additional, Laskin, Alexander, additional, and Pratt, Kerri A., additional

Published
2017
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9. Mechanisms of hypertension during and after orthotopic liver transplantation in children

Author

Lawless, Stephen, Ellis, Demetrius, Thompson, Ann, Cook, Ryan D., Esquivel, Carlos, and Starzl, Thomas Earl

Subjects
Kidneys -- Physiological aspects, Children, Cyclosporine -- Adverse and side effects, Liver -- Transplantation, Hypertension -- Complications, Transplantation of organs, tissues, etc. -- Physiological aspects, Immunosuppressive agents -- Physiological aspects, Health
Abstract

Eighty percent of orthotopic liver transplants in children are complicated by hypertension (high blood pressure). Nine pediatric liver transplant patients were studied to assess hormone changes that result in the development of high blood pressure following liver transplantation. None of the patients had a history of high blood pressure or kidney disease. The study's goal was to determine how the physiologic mechanisms that normally maintain blood pressure and tissue perfusion respond to immediate stresses of liver transplantation, and how these responses can cause hypertension. Cyclosporine, an immunosuppressive drug needed to reduce tissue rejection in organ transplant recipients, greatly increases the risk of hypertension; control of hypertension must take cyclosporine regimens into account since this drug promotes the retention of salt and water, which can contribute to hypertension. During surgery arginine vasopressin (AVP) is released, and this hormone can also raise blood pressure. Acute salt load leads to increased atrial natriuretic factor. Massive fluid shifts occur during the period surrounding the transplant procedure; these shifts result in a transition from almost normal blood pressure to acute severe systemic hypertension. Physiologic compensation mechanisms regulating AVP and ANF occur, but compensation results in intravascular hypervolemia, high levels of fluid in blood vessels, and acute salt overload. The kidney can not respond with adequate fluid removal. Hypertension that develops in patients after transplantation is due to a variety of factors and may involve salt and volume overload in conjunction with the absence of a diuretic or natriuretic response by the kidney to these loads.

Published
1989

19. Chemoembolization of hepatocellular carcinoma: patient status at presentation and outcome over 15 years at a single center.

Author

Brown DB, Chapman WC, Cook RD, Kerr JR, Gould JE, Pilgram TK, and Darcy MD

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Hepatocellular pathology, Cohort Studies, Disease-Free Survival, Female, Humans, Liver Neoplasms pathology, Liver Transplantation, Male, Middle Aged, Survival Rate, Treatment Outcome, United States, Carcinoma, Hepatocellular mortality, Carcinoma, Hepatocellular therapy, Chemoembolization, Therapeutic, Liver Neoplasms mortality, Liver Neoplasms therapy
Abstract

Objective: We report the outcome of the care of 209 patients with hepatocellular carcinoma with a focus on relevant scoring systems for predicting overall survival and time to progression and on changes in presentation status and outcome from 1991 to 2006., Materials and Methods: Hepatic arterial chemoembolization was performed on 209 patients in 375 sessions. Disease status was evaluated with the Child-Pugh, Okuda, Cancer of the Liver Italian Program, and American Joint Committee on Cancer (AJCC) systems. Changes in status at presentation from 1991 to 2006 and change in overall survival period and time to progression were analyzed., Results: Median and mean overall survival periods for the entire group were 376 and 574 +/- 61 days. Median and mean times to progression were 267 and 409 +/- 54 days. Forty-nine patients underwent liver transplantation a median of 143 days after chemoembolization. The median and mean overall survival times among patients not undergoing transplantations were 466 and 574 +/- 61 days. Okuda score (p < 0.0001) and AJCC stage (p = 0.014) were the best predictors of overall survival and time to progression, respectively. Patients with disease with an Okuda I score and in AJCC stage I or II had median and mean overall survival periods of 667 and 992 +/- 176 days and times to progression of 378 and 589 +/- 110 days. Clinical status at presentation, overall survival period (p = 0.64), and time to progression (p = 0.44) were unchanged from 1991 to 2006. The 30-day mortality was 3.2%., Conclusion: Patients treated with hepatic arterial chemoembolization for HCC in Okuda score I and AJCC stage I or II have more durable survival than previously reported in a U.S. population.

Published
2008
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