5,026 results on '"Cook, G"'
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2. Progression free survival of myeloma patients who become IFE-negative correlates with the detection of residual monoclonal free light chain (FLC) by mass spectrometry
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Giles, H. V., Drayson, M. T., Kishore, B., Pawlyn, C., Kaiser, M., Cook, G., de Tute, R., Owen, R. G., Cairns, D., Menzies, T., Davies, F. E., Morgan, G. J., Pratt, G., and Jackson, G. H.
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- 2024
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3. Varied Operations by Hebbert Bruce (review)
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Cook, G. Ramsay
- Published
- 2017
4. UK Stakeholder Perspectives on Surrogate Endpoints in Cancer, and the Potential for UK Real-World Datasets to Validate Their Use in Decision-Making
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Baldwin D, Carmichael J, Cook G, Navani N, Peach J, Slater R, Wheatstone P, Wilkins J, Allen-Delingpole N, Kerr CEP, and Siddiqui K
- Subjects
cancer ,surrogate endpoints ,real-world data ,multiple myeloma ,lung cancer ,quality of life ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
David Baldwin,1 Jonathan Carmichael,2 Gordon Cook,3 Neal Navani,4,5 James Peach,6 Ruth Slater,7 Pete Wheatstone,8 Julia Wilkins,7 Nicola Allen-Delingpole,9 Cicely EP Kerr,10 Khalid Siddiqui11 1Department of Respiratory Medicine, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; 2Department of Oncology, The National Institute for Health Research Leeds In Vitro Diagnostics Co-Operative (NIHR Leeds MIC), Leeds, UK; 3Cancer Research UK Trials Unit, LICTR, University of Leeds & NIHR (Leeds) IVD MIC, Leeds, UK; 4Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK; 5Department of Thoracic Medicine, University College London Hospital, London, UK; 6Human Centric Drug Discovery, Wood Centre for Innovation, Oxford, UK; 7Health Economics Unit, London, UK; 8Patient and Public Involvement and Engagement Group, DATA-CAN, London, UK; 9The Association of the British Pharmaceutical Industry, London, UK; 10Research Data Scotland, Bayes Centre, Edinburgh, UK; 11Janssen-Cilag Ltd, High Wycombe, UKCorrespondence: James Peach, Human Centric Drug Discovery, Wood Centre for Innovation, Quarry Road, Oxford, OX3 8SB, UK, Email james@humancentricdd.comAbstract: Duration of overall survival in patients with cancer has lengthened due to earlier detection and improved treatments. However, these improvements have created challenges in assessing the impact of newer treatments, particularly those used early in the treatment pathway. As overall survival remains most decision-makers’ preferred primary endpoint, therapeutic innovations may take a long time to be introduced into clinical practice. Moreover, it is difficult to extrapolate findings to heterogeneous populations and address the concerns of patients wishing to evaluate everyday quality and extension of life. There is growing interest in the use of surrogate or interim endpoints to demonstrate robust treatment effects sooner than is possible with measurement of overall survival. It is hoped that they could speed up patients’ access to new drugs, combinations, and sequences, and inform treatment decision-making. However, while surrogate endpoints have been used by regulators for drug approvals, this has occurred on a case-by-case basis. Evidence standards are yet to be clearly defined for acceptability in health technology appraisals or to shape clinical practice. This article considers the relevance of the use of surrogate endpoints in cancer in the UK context, and explores whether collection and analysis of real-world UK data and evidence might contribute to validation.Keywords: cancer, surrogate endpoints, real-world data, multiple myeloma, lung cancer, quality of life
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- 2024
5. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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6. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, 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Warmington, J, Warner, B, Warner, C, Warnock, L, Warran, S, Warren, J, Warren, L, Warren, R, Warren, Y, Warrender, D, Warren-Miell, H, Warris, A, Warwick, G, Wassall, H, Wasserman, S, Wasson, E, Watchorn, HJ, Waterfall, H, Waters, A, Waters, D, Waterstone, M, Watkin, A, Watkins, C, Watkins, E, Watkins, K, Watkins, L, Watson, A, Watson, AJR, Watson, E, Watson, F, Watson, JGR, Watson, L, Watson, P, Watson, R, Watson, K, Watters, M, Watterson, D, Wattimena, K, Watts, D, Watts, J, Watts, M, Waugh, V, Wayman, E, Wayman, M, Wazir, A, Weatherhead, M, Weatherly, N, Webb, C, Webb, H, Webb, K, Webb, S, Websdale, C, Webster, D, Webster, I, Webster, J, Webster, T, Wedlin, J, Wee, L, Weerakoon, R, Weerasinghe, T, Weeratunga, J, Weetman, M, Wei, S, Weichert, I, Welch, E, Welch, H, Welch, J, Welch, L, Welch, S, Welham, B, Weller, S, Wellings, L, Wells, B, Wellstead, S, Welsh, B, Welsh, R, Welters, I, Welton, R, Wenn, V, Wentworth, L, Wesonga, J, Wesseldine, K, West, J, West, M, West, R, West, S, Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, A, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittaker, E, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, S, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, CV, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, P, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, C, Williamson, D, Williamson, J, Williamson, JD, Williamson, R, Williamson, H, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Willson, F, Willson, J, Wilson, A, Wilson, B, Wilson, D, Wilson, I, Wilson, J, Wilson, K, Wilson, K-A, Wilson, L, Wilson, M, Wilson, S, Wilson, T, Win, KLY, Win, M, Win, T, Win, TT, Win, WYW, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, WIshlade, T, Witele, E, Withers, N, Wittes, J, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C-H, Wong, C-M, Wong, E, Wong, JSY, Wong, KY, Wong, MY, Wong, N, Wong, S, Wong, T, Wongkyezeng, AA, Wood, A, Wood, C, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, F, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, BE, Xia, Z, Yacoba, E, Yadav, S, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, WL, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, T, Yates, M, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yen, LM, Yeoh, A, Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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7. Plane sections of Fermat surfaces over finite fields
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Borges, H., Cook, G., and Coutinho, M.
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Mathematics - Algebraic Geometry - Abstract
In this paper, we characterize all curves over $\mathbb{F}_q$ arising from a plane section $$ \mathcal{P} : X_3-e_0X_0-e_1X_1-e_2X_2 = 0 $$ of the Fermat surface $$ \mathcal{S} : X_0^d + X_1^d + X_2^d +X_3^d = 0, $$ where $q = p^{h} = 2d+1$ is a prime power, $p >3$, and $e_0, e_1, e_2 \in \mathbb{F}_q$. In particular, we will prove that any nonlinear component $\mathcal{G} \subseteq \mathcal{P} \cap \mathcal{S} $ is a smooth classical curve of degree $n\leqslant d$ attaining the St\"ohr-Voloch bound $$ \# \mathcal{G}(\mathbb{F}_q) \leqslant \frac{1}{2} n(n+q-1) - \frac{1}{2} i(n-2), $$ with $i \in \{0,1,2,3,n,3n\}$.
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- 2018
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8. What lies behind radiocarbon intercomparisons and the design of the new intercomparison, GIRI?
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Scott, E.M., Naysmith, P., and Cook, G.
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- 2022
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9. The ability of post-chemoradiotherapy DWI ADCmean and 18F-FDG SUVmax to predict treatment outcomes in head and neck cancer: impact of human papilloma virus oropharyngeal cancer status
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Connor, S., Sit, C., Anjari, M., Lei, M., Guerrero-Urbano, T., Szyszko, T., Cook, G., Bassett, P., and Goh, V.
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- 2021
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10. Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
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Dimopoulos, M.A., Moreau, P., Terpos, E., Mateos, M.V., Zweegman, S., Cook, G., Delforge, M., Hájek, R., Schjesvold, F., Cavo, M., Goldschmidt, H., Facon, T., Einsele, H., Boccadoro, M., San-Miguel, J., Sonneveld, P., and Mey, U.
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- 2021
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11. Scientific dating
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Marshall, P., primary, Pearson, M. Parker, additional, Schwenninger, J.-L., additional, and Cook, G., additional
- Published
- 2021
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12. Finiteness properties of totally disconnected locally compact groups
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Castellano, I. and Corob Cook, G.
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- 2020
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13. REMAP: Response Evaluation in Metastatic Renal Cell Cancer (mRCC) using 18F-FDG PET/MRI
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Manickavasagar, T., primary, Kelly-Morland, C., additional, Rudman, S., additional, Crawley, D., additional, Cook, G., additional, and Goh, V., additional
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- 2024
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14. Construction and application of infectious citrus viroids for biological indexing
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Steyn, C, Cook, G, Burger, J T, and Maree, H J
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Citrus viroids ,in vitro transcription ,slash-inoculation ,infectious - Abstract
Viroid species identified in citrus induce a range of symptoms in this host as well as in non-citrus hosts. Currently, 7 citrus viroid species are recognized including Citrus bent leaf viroid (CBLVd), Hop stunt viroid (HSVd), Citrus dwarfing viroid (CDVd), Citrus bark cracking viroid (CBCVd), Citrus viroid V (CVd-V), Citrus viroid VI (CVd-VI) and Citrus exocortis viroid (CEVd). Cachexia-inducing variants of HSVd and CEVd, which causes exocortis, are considered severe pathogens of citrus, whereas other viroid species induce less severe symptoms such as stunting, either singly or in combination. Some viroid species, such as CDVd, have previously been used to deliberately induce stunting for high density planting of citrus, but studies on the effects of commercial orchards are limited. Research on the effect of viroid species requires the isolation of single viroid species. Biological isolation of single species from naturally infected citrus is challenging since viroids seldom occur as single infections and are often found in combination with various other pathogens. The production of single viroid species clones for in vitro transcription enables the generation of a single viroid species inoculum for research applications and circumvents the need for maintenance of sources in plants. Complete genomes of 7 viroid strains including CBLVd, 2 HSVd variants (CVd-IIa and CVd-IIb), CDVd, CBCVd, CVd-V and CEVd were cloned with a leading T7 promoter sequence to facilitate in vitro transcription. Circularized RNA transcripts were successfully used to transfect ‘Etrog’ citron (Citrus medica) by slash-inoculation that developed typical citrus viroid symptoms.
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- 2016
15. A property of the lamplighter group
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Castellano I., Cook G. Corob, and Kropholler P.H.
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lamplighter group ,commensurate subgroups ,inert subgroups ,intrinsic dimension entropy ,primary 16d10 ,secondary 16e50, 16e20 ,Mathematics ,QA1-939 - Abstract
We show that the inert subgroups of the lamplighter group fall into exactly five commensurability classes. The result is then connected with the theory of totally disconnected locally compact groups and with algebraic entropy.
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- 2020
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16. Subgroups, hyperbolicity and cohomological dimension for totally disconnected locally compact groups
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Arora, S, Castellano, I, Corob Cook, G, Martinez-Pedroza, E, Arora S., Castellano I., Corob Cook G., Martinez-Pedroza E., Arora, S, Castellano, I, Corob Cook, G, Martinez-Pedroza, E, Arora S., Castellano I., Corob Cook G., and Martinez-Pedroza E.
- Abstract
This paper is part of the program of studying large-scale geometric properties of totally disconnected locally compact groups, TDLC-groups, by analogy with the theory for discrete groups. We provide a characterization of hyperbolic TDLC-groups, in terms of homological isoperimetric inequalities. This characterization is used to prove the main result of this paper: for hyperbolic TDLC-groups with rational discrete cohomological dimension ≤ 2, hyperbolicity is inherited by compactly presented closed subgroups. As a consequence, every compactly presented closed subgroup of the automorphism group Aut(X) of a negatively curved locally finite 2-dimensional building X is a hyperbolic TDLC-group, whenever Aut(X) acts with finitely many orbits on X. Examples where this result applies include hyperbolic Bourdon's buildings. We revisit the construction of small cancellation quotients of amalgamated free products, and verify that it provides examples of hyperbolic TDLC-groups of rational discrete cohomological dimension 2 when applied to amalgamated products of profinite groups over open subgroups. We raise the question of whether our main result can be extended to locally compact hyperbolic groups if rational discrete cohomological dimension is replaced by asymptotic dimension. We prove that this is the case for discrete groups and sketch an argument for TDLC-groups.
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- 2023
17. Middle Bronze Age humidity and temperature variations, and societal changes in East-Central Europe
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Demény, A., Kern, Z., Czuppon, Gy, Németh, A., Schöll-Barna, G., Siklósy, Z., Leél-Őssy, Sz, Cook, G., Serlegi, G., Bajnóczi, B., Sümegi, P., Király, Á., Kiss, V., Kulcsár, G., and Bondár, M.
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- 2019
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18. 14C wiggle-matching of short tree-ring sequences from post-medieval buildings in England
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Marshall, P., Bayliss, A., Farid, S., Tyers, C., Bronk Ramsey, C., Cook, G., Doğan, T., Freeman, S.P.H.T., İlkmen, E., and Knowles, T.
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- 2019
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19. Comparison of U-Net and Transformer Based Swin-Unet Architectures for Segmenting Inflammation in Gamma Camera 99mTc-Maraciclatide Imaging
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Cobb, R. B., primary, Cook, G., additional, and Reader, A. J., additional
- Published
- 2023
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- View/download PDF
20. Short communication: Circadian variations and day-to-day variability of clinical signs used for the early diagnosis of pneumonia within and between calves
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Lowie, T., primary, Vandewalle, J., additional, Hanley-Cook, G., additional, Pardon, B., additional, and Bokma, J., additional
- Published
- 2023
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- View/download PDF
21. Endocrine Imaging
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
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- 2020
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22. Lung Imaging
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
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- 2020
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23. Tumour Imaging
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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24. Bone scintigraphy
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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25. Gut and Infection Imaging
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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26. Renal Radionuclide Studies
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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27. Cardiac Imaging
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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28. Miscellaneous
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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29. MCQs in Clinical Nuclear Medicine
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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30. PET Imaging
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Scullion, D. A., primary, Cook, G., additional, Allan, R., additional, and Cunningham, D. A., additional
- Published
- 2020
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31. Burning following tree fall causes local elimination of annual sorghum
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Andersen, Alan N, Bradley, M., Cook, G D, Eager, R, Lawes, M J, Richards, A, Schatz, Jon, BioStor, and BHL Australia
- Published
- 2008
32. Temporal, spatial, and interspecific variation in geochemical signatures within fish otoliths, bivalve larval shells, and crustacean larvae
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Carson, H S, Lopez-Duarte, P C, Cook, G S, Fodrie, F J, Becker, B J, DiBacco, C, and Levin, L A
- Published
- 2013
33. What Controls Connectivity? An Empirical, Multi-Species Approach
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Lopez-Duarte, P. C, Carson, H. S, Cook, G. S, Fodrie, F. J, Becker, B. J, DiBacco, C., and Levin, L. A
- Published
- 2012
34. A Decade of Community MRSA in New Zealand
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Smith, J. M. B. and Cook, G. M.
- Published
- 2005
35. Stable characteristic evolution of generic 3-dimensional single-black-hole spacetimes
- Author
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Alliance, The Binary Black Hole Grand Challenge, Gomez, R., Lehner, L., Marsa, R., Winicour, J., Abrahams, A., Anderson, A., Anninos, P., Baumgarte, T., Bishop, N., Browne, S. Brandt J., Camarda, K., Choptuik, M., Correl, R., Cook, G., Evans, C., Finn, L., Fox, G., Haupt, T., Huq, M., Kidder, L., Klasky, S., Laguna, P., Landry, W., Lenaghan, J., Masso, J., Matzner, R. A., Mitra, S., Papadopoulos, P., Parashar, M., Rezzolla, L., Rupright, M., Saied, F., Saylor, P., Scheel, M., Seidel, E., Shapiro, S., Shoemaker, D., Smarr, L., Szilagyi, B., Teukolsky, A., van Putten, M. H. P. M., Walker, P., and York, J. W.
- Subjects
General Relativity and Quantum Cosmology - Abstract
We report new results which establish that the accurate 3-dimensional numerical simulation of generic single-black-hole spacetimes has been achieved by characteristic evolution with unlimited long term stability. Our results cover a selection of distorted, moving and spinning single black holes, with evolution times up to 60,000M., Comment: 4 pages, 3 figures
- Published
- 1998
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36. Waveform propagation in black hole spacetimes: evaluating the quality of numerical solutions
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Rezzolla, L., Abrahams, A. M., Baumgarte, T. W., Cook, G. B., Scheel, M. A., Shapiro, S. L., and Teukolsky, S. A.
- Subjects
General Relativity and Quantum Cosmology - Abstract
We compute the propagation and scattering of linear gravitational waves off a Schwarzschild black hole using a numerical code which solves a generalization of the Zerilli equation to a three dimensional cartesian coordinate system. Since the solution to this problem is well understood it represents a very good testbed for evaluating our ability to perform three dimensional computations of gravitational waves in spacetimes in which a black hole event horizon is present., Comment: 13 pages, RevTeX, to appear in Phys. Rev. D
- Published
- 1997
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37. Boosted three-dimensional black-hole evolutions with singularity excision
- Author
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Alliance, The Binary Black Hole Grand Challenge, Cook, G. B., Huq, M. F., Klasky, S. A., Scheel, M. A., Abrahams, A. M., Anderson, A., Anninos, P., Baumgarte, T. W., Bishop, N. T., Brandt, S. R., Browne, J. C., Camarda, K., Choptuik, M. W., Evans, C. R., Finn, L. S., Fox, G. C., Gomez, R., Haupt, T., Kidder, L. E., Laguna, P., Landry, W., Lehner, L., Lenaghan, J., Marsa, R. L., Masso, J., Matzner, R. A., Mitra, S., Papadopoulos, P., Parashar, M., Rezzolla, L., Rupright, M. E., Saied, F., Saylor, P. E., Seidel, E., Shapiro, S. L., Shoemaker, D., Smarr, L., Suen, W. M., Szilagyi, B., Teukolsky, S. A., van Putten, M. H. P. M., Walker, P., Winicour, J., and York Jr, J. W.
- Subjects
General Relativity and Quantum Cosmology - Abstract
Binary black hole interactions provide potentially the strongest source of gravitational radiation for detectors currently under development. We present some results from the Binary Black Hole Grand Challenge Alliance three- dimensional Cauchy evolution module. These constitute essential steps towards modeling such interactions and predicting gravitational radiation waveforms. We report on single black hole evolutions and the first successful demonstration of a black hole moving freely through a three-dimensional computational grid via a Cauchy evolution: a hole moving ~6M at 0.1c during a total evolution of duration ~60M.
- Published
- 1997
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38. Gravitational wave extraction and outer boundary conditions by perturbative matching
- Author
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Alliance, The Binary Black Hole Grand Challenge, Abrahams, A. M., Rezzolla, L., Rupright, M. E., Anderson, A., Anninos, P., Baumgarte, T. W., Bishop, N. T., Brandt, S. R., Browne, J. C., Camarda, K., Choptuik, M. W., Cook, G. B., Evans, C. R., Finn, L. S., Fox, G., Gomez, R., Haupt, T., Huq, M. F., Kidder, L. E., Klasky, S., Laguna, P., Landry, W., Lehner, L., Lenaghan, J., Marsa, R. L., Masso, J., Matzner, R. A., Mitra, S., Papadopoulos, P., Parashar, M., Saied, F., Saylor, P. E., Scheel, M. A., Seidel, E., Shapiro, S. L., Shoemaker, D., Smarr, L., Szilagyi, B., Teukolsky, S. A., van Putten, M. H. P. M., Walker, P., Winicour, J., and York Jr, J. W.
- Subjects
General Relativity and Quantum Cosmology - Abstract
We present a method for extracting gravitational radiation from a three-dimensional numerical relativity simulation and, using the extracted data, to provide outer boundary conditions. The method treats dynamical gravitational variables as nonspherical perturbations of Schwarzschild geometry. We discuss a code which implements this method and present results of tests which have been performed with a three dimensional numerical relativity code.
- Published
- 1997
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- View/download PDF
39. General Relativistic Models of Binary Neutron Stars in Quasiequilibrium
- Author
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Baumgarte, T. W., Cook, G. B., Scheel, M. A., Shapiro, S. L., and Teukolsky, S. A.
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - Abstract
We perform fully relativistic calculations of binary neutron stars in corotating, circular orbit. While Newtonian gravity allows for a strict equilibrium, a relativistic binary system emits gravitational radiation, causing the system to lose energy and slowly spiral inwards. However, since inspiral occurs on a time scale much longer than the orbital period, we can treat the binary to be in quasiequilibrium. In this approximation, we integrate a subset of the Einstein equations coupled to the relativistic equation of hydrostatic equilibrium to solve the initial value problem for binaries of arbitrary separation. We adopt a polytropic equation of state to determine the structure and maximum mass of neutron stars in close binaries for polytropic indices n=1, 1.5 and 2. We construct sequences of constant rest-mass and locate turning points along energy equilibrium curves to identify the onset of orbital instability. In particular, we locate the innermost stable circular orbit (ISCO) and its angular velocity. We construct the first contact binary systems in full general relativity. These arise whenever the equation of state is sufficiently soft >= 1.5. A radial stability analysis reveals no tendency for neutron stars in close binaries to collapse to black holes prior to merger., Comment: 14 pages, 8 figures, RevTeX
- Published
- 1997
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- View/download PDF
40. The Stability of Relativistic Neutron Stars in Binary Orbit
- Author
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Baumgarte, T. W., Cook, G. B., Scheel, M. A., Shapiro, S. L., and Teukolsky, S. A.
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - Abstract
We analyze the stability of relativistic, quasi-equilibrium binary neutron stars in synchronous circular orbit. We explore stability against radial collapse to black holes prior to merger, and against orbital plunge. We apply theorems based on turning points along uniformly rotating sequences of constant angular momentum and rest mass to locate the onset of secular instabilities. We find that inspiraling binary neutron stars are stable against radial collapse to black holes all the way down to the innermost stable circular orbit., Comment: 4 pages, 3 figures, RevTeX
- Published
- 1997
- Full Text
- View/download PDF
41. Binary Neutron Stars in General Relativity: Quasi-Equilibrium Models
- Author
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Baumgarte, T. W., Cook, G. B., Scheel, M. A., Shapiro, S. L., and Teukolsky, S. A.
- Subjects
General Relativity and Quantum Cosmology ,Astrophysics - Abstract
We perform fully relativistic calculations of binary neutron stars in quasi-equilibrium circular orbits. We integrate Einstein's equations together with the relativistic equation of hydrostatic equilibrium to solve the initial value problem for equal-mass binaries of arbitrary separation. We construct sequences of constant rest mass and identify the innermost stable circular orbit and its angular velocity. We find that the quasi-equilibrium maximum allowed mass of a neutron star in a close binary is slightly larger than in isolation., Comment: 4 pages, 3 figures, RevTeX
- Published
- 1997
- Full Text
- View/download PDF
42. Short communication: Circadian variations and day-to-day variability of clinical signs used for the early diagnosis of pneumonia within and between calves
- Author
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Lowie, T., Vandewalle, J., Hanley-Cook, G., Pardon, B., and Bokma, J.
- Published
- 2024
- Full Text
- View/download PDF
43. Impact of dietary diversity on Se intake adequacy in Kenya
- Author
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Ngigi, P.B., primary, Hanley-Cook, G., additional, Lachat, C., additional, Du Laing, G., additional, and Masinde, P.W., additional
- Published
- 2019
- Full Text
- View/download PDF
44. Degree Scale Anisotropy: SP94 Results
- Author
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Gundersen, J., Lim, M., Staren, J., Wuensche, C., Figueiredo, N., Koch, T. Gaier T., Meinhold, P., Seiffert, M., Cook, G., Segale, A., and Lubin, P.
- Subjects
Astrophysics - Abstract
We present results from 2 observations of the CMB performed from the South Pole during the 93-94 austral summer. Each observation employed a 3$^{\circ}$ peak to peak sinusoidal, single difference chop and consisted of a $20^{\circ}\times 1^{\circ}$ strip on the sky near our SP91 observations. The first observation used a Q-band receiver which operates in 3 bands between 38 and 45 GHz with a $1^{\circ}$ to $1_{\cdot}^{\circ }15$ FWHM beam. The second observation overlapped the first observation and used a Ka-band receiver which operates in 4 bands between 26 and 36 GHz with a $1_{\cdot}^{\circ}25$ to $1_{\cdot}^{\circ}7$ FWHM beam. Significant correlated structure is observed in all bands for each observation. The spectrum of the structure is consistent with a CMB spectrum; however, the data do not discriminate against flat or inverted spectrum point sources. The root mean square amplitude ($\pm 1\sigma$) of the combined (Ka+Q) data is $\Delta T_{rms}=42.0_{-6.8}^{+15.8}$ $\mu$K in a band of multipoles between $\ell=68^{+38}_{-32}$. A band power estimate of the CMB power spectrum, $C_\ell$, gives $\left\langle \frac{C_\ell \ell (\ell+1)}{2\pi}\right\rangle_B= 1.77_{-0.54}^{+1.58}\times 10^{-10}$. The band power estimates for the seperate Ka and Q-band results are larger than but consistent with the band power estimate of the combined Ka-band SP91 results., Comment: 14 pgs., LaTeX, 2 figs., submitted to APJL
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- 1994
45. (346) Long Term Experience with AMS-700 CXR™ Prosthesis in High-Risk Patients with Corporal Fibrosis
- Author
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Cook, G, primary, Nealon, S, additional, Badkhshan, S, additional, Sanders, S, additional, Langford, B, additional, Vandyke, M, additional, and Morey, A, additional
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- 2023
- Full Text
- View/download PDF
46. P23 EMAGINE/CARTITUDE-6: A RANDOMIZED PHASE 3 STUDY OF DVRD FOLLOWED BY CILTACABTAGENE AUTOLEUCEL VERSUS DVRD FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANT IN TRANSPLANT-ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA
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Broijl, A., primary, San-Miguel, J., additional, Suzuki, K., additional, Krishnan, A., additional, van de Donk, N., additional, Cook, G., additional, Jakubowiak, A., additional, Madduri, D., additional, Afifi, S., additional, Stevens, A., additional, Schecter, J., additional, Deraedt, W., additional, Kuppens, S., additional, Mistry, P., additional, Pacaud, L., additional, Boccadoro, M., additional, Gay, F., additional, Mina, R., additional, Rasche, L., additional, Moreau, P., additional, Mateos, M., additional, Einsele, H., additional, and Sonneveld, P., additional
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- 2023
- Full Text
- View/download PDF
47. Variation in the Composition and Structure of Tropical Savannas as a Function of Rainfall and Soil Texture Along a Large-Scale Climatic Gradient in the Northern Territory, Australia
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Williams, R. J., Duff, G. A., and Cook, G. D.
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- 1996
48. Shrub Invasion of a Tropical Wetland: Implications for Weed Management
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Cook, G. D., Setterfield, S. A., and Maddison, J. P.
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- 1996
- Full Text
- View/download PDF
49. 'No one's ever said anything about sleep': A qualitative investigation into mothers' experiences of sleep in children with epilepsy
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Cook, G, Gringras, P, Hiscock, H, Pal, DK, Wiggs, L, Cook, G, Gringras, P, Hiscock, H, Pal, DK, and Wiggs, L
- Abstract
INTRODUCTION: Sleep problems in children with epilepsy (CWE) are common. However, little is known about parental experiences and feelings about managing sleep in their CWE. To provide the most appropriate services' provision, it is essential that the lived experience of parents of this patient group and the issues and problems that they face in managing their child's sleep is understood. METHOD: In 2018, nine mothers of CWE (aged 5-15 years) were interviewed about their perceptions and experiences around their child's sleep, sleep problems and their management, the impact of sleep difficulties on the child and their family and available support. RESULTS: Four themes were identified that represented the nature of the child's sleep problems, including settling and night-waking issues, parasomnias and child anxiety around sleep. Seven themes represented mothers' experiences of managing their child's sleep and any associated problems, including the longstanding challenging nature of child sleep issues, management strategies adopted, challenges related to managing sleep over time, the link between sleep and seizures, the negative impact of poor sleep on daytime functioning, role of antiseizure medication and maternal concerns about child sleep. One theme represented the perceived lack of information, help and support available. CONCLUSIONS: Findings suggest there are unmet needs in supporting parents to deal with sleep, sleep problems and their management in CWE. PATIENT OR PUBLIC CONTRIBUTION: This individual study was conducted under the umbrella of the CASTLE research programme (see https://castlestudy.org.uk/). Parents who have lived experience of parenting a child with epilepsy were co-applicants for the programme and were involved in the original conception, aims, design and funding application for the research programme (including the project reported in this paper) and advised on project design. Mothers of CWE who have lived experience of managing sleep and sleep
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- 2023
50. Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E: a protocol for a randomised controlled trial comparing an online behavioural sleep intervention with standard care in children with Rolandic epilepsy
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Al-Najjar, N, Bray, L, Carter, B, Castle, AP, Collingwood, A, Cook, G, Crudgington, H, Currier, J, Dietz, KC, Hardy, WAS, Hiscock, H, Hughes, D, Morris, C, Roberts, D, Rouncefield-Swales, A, Saron, H, Spowart, C, Stibbs-Eaton, L, Tudur Smith, C, Watson, V, Whittle, L, Wiggs, L, Wood, E, Gringras, P, Pal, DK, Al-Najjar, N, Bray, L, Carter, B, Castle, AP, Collingwood, A, Cook, G, Crudgington, H, Currier, J, Dietz, KC, Hardy, WAS, Hiscock, H, Hughes, D, Morris, C, Roberts, D, Rouncefield-Swales, A, Saron, H, Spowart, C, Stibbs-Eaton, L, Tudur Smith, C, Watson, V, Whittle, L, Wiggs, L, Wood, E, Gringras, P, and Pal, DK
- Abstract
INTRODUCTION: Sleep and epilepsy have an established bidirectional relationship yet only one randomised controlled clinical trial has assessed the effectiveness of behavioural sleep interventions for children with epilepsy. The intervention was successful, but was delivered via face-to-face educational sessions with parents, which are costly and non-scalable to population level. The Changing Agendas on Sleep, Treatment and Learning in Epilepsy (CASTLE) Sleep-E trial addresses this problem by comparing clinical and cost-effectiveness in children with Rolandic epilepsy between standard care (SC) and SC augmented with a novel, tailored parent-led CASTLE Online Sleep Intervention (COSI) that incorporates evidence-based behavioural components. METHODS AND ANALYSES: CASTLE Sleep-E is a UK-based, multicentre, open-label, active concurrent control, randomised, parallel-group, pragmatic superiority trial. A total of 110 children with Rolandic epilepsy will be recruited in outpatient clinics and allocated 1:1 to SC or SC augmented with COSI (SC+COSI). Primary clinical outcome is parent-reported sleep problem score (Children's Sleep Habits Questionnaire). Primary health economic outcome is the incremental cost-effectiveness ratio (National Health Service and Personal Social Services perspective, Child Health Utility 9D Instrument). Parents and children (≥7 years) can opt into qualitative interviews and activities to share their experiences and perceptions of trial participation and managing sleep with Rolandic epilepsy. ETHICS AND DISSEMINATION: The CASTLE Sleep-E protocol was approved by the Health Research Authority East Midlands (HRA)-Nottingham 1 Research Ethics Committee (reference: 21/EM/0205). Trial results will be disseminated to scientific audiences, families, professional groups, managers, commissioners and policymakers. Pseudo-anonymised individual patient data will be made available after dissemination on reasonable request. TRIAL REGISTRATION NUMBER: ISRCTN1320232
- Published
- 2023
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