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1. A Canadian survey of perceptions and practices related to ordering of blood tests in the intensive care unit

Author

Rahman, M. Omair, Charbonney, Emannuel, Vaisler, Ryan, Khalifa, Abubaker, Alhazzani, Waleed, Gossack-Keenan, Kiera, Garland, Allan, Karachi, Timothy, Duan, Erick, Bagshaw, Sean M., Meade, Maureen O., Hillis, Chris, Kavsak, Peter, Born, Karen, Mbuagbaw, Lawrence, Siegal, Deborah, Millen, Tina, Scales, Damon, Amaral, Andre, English, Shane, McCredie, Victoria A., Dodek, Peter, Cook, Deborah J., and Rochwerg, Bram

Published
2024
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3. The 3 Wishes Program Improves Families’ Experience of Emotional and Spiritual Support at the End of Life

Author

Neville, Thanh H, Taich, Zachary, Walling, Anne M, Bear, Danielle, Cook, Deborah J, Tseng, Chi-Hong, and Wenger, Neil S

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Humans, Terminal Care, Hospice Care, Spirituality, Emotions, Death, Family, End of life, Palliative care, Intensive care unit, Clinical Sciences, General & Internal Medicine, Clinical sciences, Health services and systems, Public health
Abstract

BackgroundThe end-of-life (EOL) experience in the intensive care unit (ICU) is emotionally challenging, and there are opportunities for improvement. The 3 Wishes Program (3WP) promotes the dignity of dying patients and their families by eliciting and implementing wishes at the EOL.AimTo assess whether the 3WP is associated with improved ratings of EOL care.Program descriptionIn the 3WP, clinicians elicit and fulfill simple wishes for dying patients and their families.Setting2-hospital academic healthcare system.ParticipantsDying patients in the ICU and their families.Program evaluationA modified Bereaved Family Survey (BFS), a validated tool for measuring EOL care quality, was completed by families of ICU decedents approximately 3 months after death. We compared patients whose care involved the 3WP to those who did not using three BFS-derived measures: Respectful Care and Communication (5 questions), Emotional and Spiritual Support (3 questions), and the BFS-Performance Measure (BFS-PM, a single-item global measure of care).ResultsOf 314 completed surveys, 117 were for patients whose care included the 3WP. Bereaved families of 3WP patients rated the Emotional and Spiritual Support factor significantly higher (7.5 vs. 6.0, p = 0.003, adjusted p = 0.001) than those who did not receive the 3WP. The Respectful Care and Communication factor and BFS-PM were no different between groups.DiscussionThe 3WP is a low-cost intervention that may be a feasible strategy for improving the EOL experience.

Published
2023

6. Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives

Author

Vanstone, Meredith G., Krewulak, Karla, Taneja, Shipra, Swinton, Marilyn, Fiest, Kirsten, Burns, Karen E.A., Debigare, Sylvie, Dionne, Joanna C., Guyatt, Gordon, Marshall, John C., Muscedere, John G., Deane, Adam M., Finfer, Simon, Myburgh, John A., Gouskos, Audrey, Rochwerg, Bram, Ball, Ian, Mele, Tina, Niven, Daniel J., English, Shane W., Verhovsek, Madeleine, and Cook, Deborah J.

Published
2024
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7. Frequency of screening and SBT Technique Trial—North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan

Author

Burns, Karen E. A., Lafrienier-Roula, Myriam, Hill, Nicholas S., Cook, Deborah J., Seely, Andrew J. E., Rochwerg, Bram, Mayette, Michael, D’Aragon, Frederick, Devlin, John W., Dodek, Peter, Tanios, Maged, Gouskos, Audrey, Turgeon, Alexis F., Aslanian, Pierre, Sia, Ying Tung, Beitler, Jeremy R., Hyzy, Robert, Criner, Gerard J., Kassis, Elias Baedorf, Tsang, Jennifer L. Y., Meade, Maureen O., Liebler, Janice M., Wong, Jessica T. Y., and Thorpe, Kevin E.

Published
2023
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8. Sacrifice and solidarity: a qualitative study of family experiences of death and bereavement in critical care settings during the pandemic

Author

Dennis, Brittany, Vanstone, Meredith, Swinton, Marilyn, Vegas, Daniel Brandt, Dionne, Joanna C, Cheung, Andrew, Clarke, France J, Hoad, Neala, Boyle, Anne, Huynh, Jessica, Toledo, Feli, Soth, Mark, Neville, Thanh H, Fiest, Kirsten, and Cook, Deborah J

Subjects
Health Services and Systems, Health Sciences, Clinical Research, Good Health and Well Being, Bereavement, COVID-19, Canada, Critical Care, Family, Grief, Humans, Pandemics, Qualitative Research, SARS-CoV-2, palliative care, qualitative research, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

BackgroundPandemic-related restrictions are expected to continue to shape end-of-life care and impact the experiences of dying hospitalised patients and their families.ObjectiveTo understand families' experiences of loss and bereavement during and after the death of their loved one amidst the SARS-CoV-2 (COVID-19) pandemic.DesignQualitative descriptive study.SettingThree acute care units in a Canadian tertiary care hospital.ParticipantsFamily members of 28 hospitalised patients who died from March-July 2020.Main outcome measuresQualitative semistructured interviews conducted 6-16 months after patient death inquired about family experiences before and beyond the death of their loved one and garnered suggestions to improve end-of-life care.ResultsPandemic restrictions had consequences for families of dying hospitalised patients. Most family members described an attitude of acquiescence, some framing their experience as a sacrifice made for the public good. Families appreciated how clinicians engendered trust in the name of social solidarity while trying to mitigate the negative impact of family separation. However, fears about the patient's experience of isolation and changes to postmortem rituals also created despair and contributed to long-lasting grief.ConclusionProfound loss and enduring grief were described by family members whose final connections to their loved one were constrained by pandemic circumstances. Families observed solidarity among clinical staff and experienced a sense of unity with staff, which alleviated some distress. Their suggestions to improve end-of-life care given pandemic restrictions included frequent, flexible communication, exceptions for family presence when safe, and targeted efforts to connect patients whose isolation is intensified by functional impairment or limited technological access.Trial registration numberNCT04602520; Results.

Published
2022

11. End-of-Life Care During the Coronavirus Disease 2019 Pandemic: The 3 Wishes Program

Author

Neville, Thanh H, Bear, Danielle K, Kao, Yuhan, Xu, Xueqing Sherry, Hjelmhaug, Kristen, Quebral, Desiree, Sanaee, Natalie, Hainje, Jessica, Arriola, Genevieve, Granone, Maria Carmela, White, Elizabeth, Chaturvedi, Apurva, Yu, Shuyi, Clarke, France, and Cook, Deborah J

Subjects
Clinical Research, Prevention, Clinical Trials and Supportive Activities, Management of diseases and conditions, 7.2 End of life care, Good Health and Well Being, coronavirus disease 2019, end-of-life, intensive care unit, palliative care, pandemic, patient-centered care
Abstract

Patient- and family-centered end-of-life care can be difficult to achieve in light of visitation restrictions and infection-prevention measures. We evaluated how the 3 Wishes Program evolved to allow continued provision of compassionate end-of-life care for critically ill patients during the coronavirus disease 2019 pandemic.DesignThis is a prospective observational study where data were collected 1 year prior to the coronavirus disease 2019 pandemic and 1 year after (from March 1, 2019, to March 31, 2021). The number of deceased patients whose care involved the 3 Wishes Program, their characteristics, and wishes were compared between prepandemic and pandemic periods.SettingSix adult ICUs of a two-hospital health system in Los Angeles.PatientsDeceased patients whose care involved the 3 Wishes Program.InterventionsThe 3 Wishes Program is a palliative care intervention in which individualized wishes are implemented for dying patients and their families.Measurements and main resultsDuring the study period, the end-of-life care for 523 patients involved the 3 Wishes Program; more patients received the 3 Wishes Program as part of their end-of-life care during the pandemic period than during the prepandemic study period (24.8 vs 17.6 patients/mo; p = 0.044). Patients who died during the pandemic compared with prepandemic were less likely to have family at the bedside and more likely to have postmortem wishes fulfilled for their families. Compared with the 736 wishes implemented during the prepandemic period, the 969 wishes completed during the pandemic were more likely to involve keepsakes. Wishes were most commonly implemented by bedside nurses, although the 3 Wishes Program project manager (not involved in the patient's clinical care) was more likely to assist remotely during the pandemic (24.8% vs 12.1%; p < 0.001).ConclusionsBedside innovations, programmatic adaptations, and institutional support made it possible for healthcare workers to continue the 3 Wishes Program and provide compassionate end-of-life care in the ICU during this pandemic.

Published
2021

12. The authors reply

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Martin Carrier, François, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Duquet-Deblois, Estel, Noël-Hunter, Monia, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Tapss, Danielle, Toupin, Guylaine, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Williams, Virginie, Lainer Palacios, Julia, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Lizotte, Patricia, Rochwerg, Bram, Millen, Tina, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Boyd, Tracy, Hunt, Miranda, Mele, Tina, Bentall, Tracey, ElKhatib, Chadia, Shahin, Jason, Khwaja, Kosar, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Mehta, Sangeeta, Detsky, Michael, Shah, Sumesh, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, Bharti, Dalisha, Perez, Adic, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Hewer, Tayne, Thompson, Patrica, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Clarke, France, Copland, Mary, Matic, Karlo, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Abdelhady, Hesham, Romagnuolo, Tina, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, McConnochie, Rachael, Simmonds, Catherine, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Eden, Amie, France, Dawn, Buehner, Ulrike, Erin Williams, Katallah Kramer, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Goodson, Jennifer, Martynoga, Robert, Byrne, Kelly, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Sol Cruz, Raulle, Sol Cruz, Rhoze, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Tirupakuzhi Vijayaraghavan, Bharath Kumar, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
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13. Expanding the 3 Wishes Project for compassionate end-of-life care: a qualitative evaluation of local adaptations

Author

Vanstone, Meredith, Neville, Thanh H, Swinton, Marilyn E, Sadik, Marina, Clarke, France J, LeBlanc, Allana, Tam, Benjamin, Takaoka, Alyson, Hoad, Neala, Hancock, Jennifer, McMullen, Sarah, Reeve, Brenda, Dechert, William, Smith, Orla M, Sandhu, Gyan, Lockington, Julie, and Cook, Deborah J

Subjects
Health Services and Systems, Health Sciences, Health Services, Clinical Research, Adult, Aged, Empathy, Female, Humans, Male, Middle Aged, Qualitative Research, Terminal Care, Intensive care unit, End of life care, Program evaluation, Qualitative research, Nursing, Public Health and Health Services, Gerontology, Health services and systems
Abstract

BackgroundThe 3 Wishes Project (3WP) is an end-of-life program that honors the dignity of dying patients by fostering meaningful connections among patients, families, and clinicians. Since 2013, it has become embedded in the culture of end-of-life care in over 20 ICUs across North America. The purpose of the current study is to describe the variation in implementation of 3WP across sites, in order to ascertain which factors facilitated multicenter implementation, which factors remain consistent across sites, and which may be adapted to suit local needs.MethodsUsing the methodology of qualitative description, we collected interview and focus group data from 85 clinicians who participated in the successful initiation and sustainment of 3WP in 9 ICUs. We describe the transition between different models of 3WP implementation, from core clinical program to the incorporation of various research activities. We describe various sources of financial and in-kind resources accessed to support the program.ResultsBeyond sharing a common goal of improving end-of-life care, sites varied considerably in organizational context, staff complement, and resources. Despite these differences, the program was successfully implemented at each site and eventually evolved from a clinical or research intervention to a general approach to end-of-life care. Key to this success was flexibility and the empowerment of frontline staff to tailor the program to address identified needs with available resources. This adaptability was fueled by cross-pollination of ideas within and outside of each site, resulting in the establishment of a network of like-minded individuals with a shared purpose.ConclusionsThe successful initiation and sustainment of 3WP relied on local adaptations to suit organizational needs and resources. The semi-structured nature of the program facilitated these adaptations, encouraged creative and important ways of relating within local clinical cultures, and reinforced the main tenet of the program: meaningful human connection at the end of life. Local adaptations also encouraged a team approach to care, supplementing the typical patient-clinician dyad by explicitly empowering the healthcare team to collectively recognize and respond to the needs of dying patients, families, and each other.Trial registrationNCT04147169 , retrospectively registered with clinicaltrials.gov on October 31, 2019.

Published
2020

14. Health economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): a cost-effectiveness analysis

Author

Lau, Vincent I., Xie, Feng, Fowler, Robert A., Rochwerg, Bram, Johnstone, Jennie, Lauzier, François, Marshall, John C., Basmaji, John, Henderson, William, Khwaja, Kosar, Loubani, Osama, Niven, Daniel J., Zarychanski, Ryan, Arabi, Yaseen M., Cartin-Ceba, Rodrigo, Thabane, Lehana, Heels-Ansdell, Diane, and Cook, Deborah J.

Published
2022
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15. Impact of restricted visitation policies during COVID-19 on critically ill adults, their families, critical care clinicians, and decision-makers: a qualitative interview study

Author

Fiest, Kirsten M., Krewulak, Karla D., Jaworska, Natalia, Spence, Krista L., Mizen, Sara J., Bagshaw, Sean M., Burns, Karen E. A., Cook, Deborah J., Fowler, Robert A., Olafson, Kendiss, Patten, Scott B., Rewa, Oleksa G., Rochwerg, Bram, Spence, Sean, West, Andrew, Stelfox, Henry T., and Parsons Leigh, Jeanna

Published
2022
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16. IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Carrier, François Martin, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Duquet-Deblois, Estel, Noël-Hunter, Monia, Tapss, Danielle, Toupin, Guylaine, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Williams, Virginie, Lainer Palacios, Julia, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Rochwerg, Bram, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Mele, Tina, Shahin, Jason, Khwaja, Kosar, Mehta, Sangeeta, Detsky, Michael, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Wood, Gordon, Ovakim, Daniel, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lizotte, Patricia, Millen, Tina, Boyd, Tracy, Hunt, Miranda, Bentall, Tracey, ElKhatib, Chadia, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Shah, Sumesh, Bharti, Dalisha, Perez, Adic, Hewer, Tayne, Thompson, Patrica, Clarke, France, Copland, Mary, Matic, Karlo, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Abdelhady, Hesham, Romagnuolo, Tina, Baig, Nadia, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Buehner, Ulrike, Kramer, Katallah, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Martynoga, Robert, Byrne, Kelly, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, McConnochie, Rachael, Simmonds, Catherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Eden, Amie, France, Dawn, Williams, Erin, Goodson, Jennifer, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Cruz, Raulle Sol, Cruz, Rhoze Sol, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Vijayaraghavan, Bharath Kumar Tirupakuzhi, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
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17. Early In-Bed Cycle Ergometry in Mechanically Ventilated Patients

Author

Kho, Michelle E., primary, Berney, Susan, additional, Pastva, Amy M., additional, Kelly, Laurel, additional, Reid, Julie C., additional, Burns, Karen E. A., additional, Seely, Andrew J., additional, D’Aragon, Frédérick, additional, Rochwerg, Bram, additional, Ball, Ian, additional, Fox-Robichaud, Alison E., additional, Karachi, Tim, additional, Lamontagne, Francois, additional, Archambault, Patrick M., additional, Tsang, Jennifer L., additional, Duan, Erick H., additional, Muscedere, John, additional, Verceles, Avelino C., additional, Serri, Karim, additional, English, Shane W., additional, Reeve, Brenda K., additional, Mehta, Sangeeta, additional, Rudkowski, Jill C., additional, Heels-Ansdell, Diane, additional, O’Grady, Heather K., additional, Strong, Geoff, additional, Obrovac, Kristy, additional, Ajami, Daana, additional, Camposilvan, Laura, additional, Tarride, Jean-Eric, additional, Thabane, Lehana, additional, Herridge, Margaret S., additional, and Cook, Deborah J., additional

Published
2024
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18. Diarrhea during critical illness: a multicenter cohort study

Author

Dionne, Joanna C., Mbuagbaw, Lawrence, Devlin, John W., Duprey, Matthew S., Cartin-Ceba, Rodrigo, Tsang, Jennifer, Sullivan, Kristen, Muscedere, John, Alshahrani, Mohammed, Szczeklik, Wojciech, Lysecki, Paul, Takaoka, Alyson, Reeve, Brenda, Campbell, Tracy, Borowska, Karolina, Serednicki, Wojciech, Cirone, Robert, Alhazzani, Waleed, Moayyedi, Paul, Armstrong, David, Thabane, Lehana, Jaeschke, Roman, Hamielec, Cindy, Karachi, Tim, and Cook, Deborah J.

Published
2022
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20. Noninvasive respiratory support following extubation in critically ill adults: a systematic review and network meta-analysis

Author

Fernando, Shannon M., Tran, Alexandre, Sadeghirad, Behnam, Burns, Karen E. A., Fan, Eddy, Brodie, Daniel, Munshi, Laveena, Goligher, Ewan C., Cook, Deborah J., Fowler, Robert A., Herridge, Margaret S., Cardinal, Pierre, Jaber, Samir, Møller, Morten Hylander, Thille, Arnaud W., Ferguson, Niall D., Slutsky, Arthur S., Brochard, Laurent J., Seely, Andrew J. E., and Rochwerg, Bram

Published
2022
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22. An environmental scan of visitation policies in Canadian intensive care units during the first wave of the COVID-19 pandemic

Author

Fiest, Kirsten M., Krewulak, Karla D., Hiploylee, Carmen, Bagshaw, Sean M., Burns, Karen E. A., Cook, Deborah J., Fowler, Robert A., Kredentser, Maia S., Niven, Daniel J., Olafson, Kendiss, Parhar, Ken Kuljit S., Patten, Scott B., Fox-Robichaud, Alison E., Rewa, Oleksa G., Rochwerg, Bram, Spence, Krista L., Straus, Sharon E., Spence, Sean, West, Andrew, Stelfox, Henry T., and Parsons Leigh, Jeanna

Published
2021
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23. Recovery after critical illness: putting the puzzle together-a consensus of 29.

Author

Azoulay, Elie, Vincent, Jean-Louis, Angus, Derek C, Arabi, Yaseen M, Brochard, Laurent, Brett, Stephen J, Citerio, Giuseppe, Cook, Deborah J, Curtis, Jared Randall, Dos Santos, Claudia C, Ely, E Wesley, Hall, Jesse, Halpern, Scott D, Hart, Nicholas, Hopkins, Ramona O, Iwashyna, Theodore J, Jaber, Samir, Latronico, Nicola, Mehta, Sangeeta, Needham, Dale M, Nelson, Judith, Puntillo, Kathleen, Quintel, Michael, Rowan, Kathy, Rubenfeld, Gordon, Van den Berghe, Greet, Van der Hoeven, Johannes, Wunsch, Hannah, and Herridge, Margaret

Subjects
Humans, Delirium, Critical Illness, Respiration, Artificial, Length of Stay, Consensus, Time Factors, Intensive Care Units, Deep Sedation, Pain Management, Long Term Adverse Effects, Cognitive dysfunction, Depression, Intensive care, Mechanical ventilation, Muscular disorder, Sedation, Traumatic stress, Weakness, Respiration, Artificial, Medical and Health Sciences, Emergency & Critical Care Medicine
Abstract

In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to cognitive dysfunction several months after ICU discharge, to give new insights into ICU acquired weakness, to emphasize the importance of value-based healthcare, and to delineate the elements of family-centered care. This consensus of 29 also provides a perspective and a research agenda about post-ICU recovery.

Published
2017

24. Enquête canadienne sur les perceptions et pratiques liées à la prescription de tests sanguins aux soins intensifs

Author

Rahman, M. Omair, primary, Charbonney, Emannuel, additional, Vaisler, Ryan, additional, Khalifa, Abubaker, additional, Alhazzani, Waleed, additional, Gossack-Keenan, Kiera, additional, Garland, Allan, additional, Karachi, Timothy, additional, Duan, Erick, additional, Bagshaw, Sean M., additional, Meade, Maureen O., additional, Hillis, Chris, additional, Kavsak, Peter, additional, Born, Karen, additional, Mbuagbaw, Lawrence, additional, Siegal, Deborah, additional, Millen, Tina, additional, Scales, Damon, additional, Amaral, Andre, additional, English, Shane, additional, McCredie, Victoria A., additional, Dodek, Peter, additional, Cook, Deborah J., additional, and Rochwerg, Bram, additional

Published
2024
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25. Multistudy Research Operations in the ICU: An Interprofessional Pandemic-Informed Approach

Author

Cook, Deborah J., Duan, Erick H., Clarke, France J., Matic, Karlo, Culgin, Sarah, Kelly, Laurel, Nelson, Katlynne S., Wallace, Christine V., Soth, Mark D., Lewis, Kimberley A., Rudkowski, Jill C., Perri, Dan, Ligori, Tania L., Jaeschke, Roman Z., Chagla, Zain, Chaudhuri, Dipayan, Wright, Angela E., Fu, Zoe Y., Reeve, Brenda K., Lee, Hilary M., Overington, Jeffrey D., Rozenberg, Anna, Bloomfield, Kimberly A., Love, Katryn, Gain, Jennifer L., Zytaruk, Nicole L., Cheung, Jason H., Thabane, Lehana, Kho, Michelle E., Alhazzani, Waleed, Bell, Matthew, Bloomfield, Kimberley, Chagla, Zain, Chaudhuri, Dipayan, Cheung, Jason, Clarke, France, Cook, Deborah, Copland, Mary, Culgin, Sarah, Duan, Erick, Fu, Zoe, Gain, Jennifer, Hurd, Abby, Jaeschke, Roman, Lee, Hilary, Love, Katryn, Kelly, Laurel, Kho, Michelle, Kim, Kate, Lewis, Kimberley, Ligori, Tania, Matic, Karlo, Nelson, Katlynne, O‘Grady, Heather, Overington, Jeffrey, Perri, Dan, Reeve, Brenda, Rozenberg, Anna, Rudkowski, Jill, Saunders, Lois, Semrau, Joanna, Soth, Mark, Wallace, Christine, Waugh, Lily, Wright, Angela, and Zytaruk, Nicole

Published
2022
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27. Venous Thromboembolism Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis

Author

Fernando, Shannon M., Tran, Alexandre, Cheng, Wei, Sadeghirad, Behnam, Arabi, Yaseen M., Cook, Deborah J., Møller, Morten Hylander, Mehta, Sangeeta, Fowler, Robert A., Burns, Karen E.A., Wells, Philip S., Carrier, Marc, Crowther, Mark A., Scales, Damon C., English, Shane W., Kyeremanteng, Kwadwo, Kanji, Salmaan, Kho, Michelle E., and Rochwerg, Bram

Published
2021
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29. Keepsakes at the End of Life

Author

Neville, Thanh H., Clarke, France, Takaoka, Alyson, Sadik, Marina, Vanstone, Meredith, Phung, Peter, Hjelmhaug, Kristen, Hainje, Jessica, Smith, Orla M., LeBlanc, Allana, Hoad, Neala, Tam, Benjamin, Reeve, Brenda, and Cook, Deborah J.

Published
2020
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32. REVISE:Re-Evaluating theInhibition ofStressErosions in the ICU: a randomised trial protocol

Author

Deane, Adam M, primary, Alhazzani, Waleed, additional, Guyatt, Gordon, additional, Finfer, Simon, additional, Marshall, John C, additional, Myburgh, John, additional, Zytaruk, Nicole, additional, Hardie, Miranda, additional, Saunders, Lois, additional, Knowles, Serena, additional, Lauzier, Francois, additional, Chapman, Marianne J, additional, English, Shane, additional, Muscedere, John, additional, Arabi, Yaseen, additional, Ostermann, Marlies, additional, Venkatesh, Balasubramanian, additional, Young, Paul, additional, Thabane, Lehana, additional, Billot, Laurent, additional, Heels-Ansdell, Diane, additional, Al-Fares, Abdulrahman A, additional, Hammond, Naomi E, additional, Hall, R, additional, Rajbhandari, Dorrilyn, additional, Poole, Alexis, additional, Johnson, Daniel, additional, Iqbal, Mobeen, additional, Reis, Gilmar, additional, Xie, Feng, additional, and Cook, Deborah J, additional

Published
2023
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33. Restricted visitation policies in acute care settings during the COVID-19 pandemic: a scoping review

Author

Moss, Stephana J., Krewulak, Karla D., Stelfox, Henry T., Ahmed, Sofia B., Anglin, Melanie C., Bagshaw, Sean M., Burns, Karen E. A., Cook, Deborah J., Doig, Christopher J., Fox-Robichaud, Alison, Fowler, Robert, Hernández, Laura, Kho, Michelle E., Kredentser, Maia, Makuk, Kira, Murthy, Srinivas, Niven, Daniel J., Olafson, Kendiss, Parhar, Ken Kuljit S., Patten, Scott B., Rewa, Oleksa G., Rochwerg, Bram, Sept, Bonnie, Soo, Andrea, Spence, Krista, Spence, Sean, Straus, Sharon, West, Andrew, Parsons Leigh, Jeanna, and Fiest, Kirsten M.

Published
2021
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39. Oxygen Saturation Target Range for Extremely Preterm Infants: A Systematic Review and Meta-analysis

Author

Manja, Veena, Lakshminrusimha, Satyan, and Cook, Deborah J

Subjects
Paediatrics, Biomedical and Clinical Sciences, Neurosciences, Clinical Research, Preterm, Low Birth Weight and Health of the Newborn, Pediatric, Prevention, Infant Mortality, Rare Diseases, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth, Good Health and Well Being, Bronchopulmonary Dysplasia, Developmental Disabilities, Enterocolitis, Necrotizing, Hearing Loss, Hospital Mortality, Humans, Infant, Infant, Extremely Premature, Infant, Low Birth Weight, Infant, Newborn, Oxygen, Oxygen Inhalation Therapy, Retinopathy of Prematurity
Abstract

ImportanceThe optimal oxygen saturation (SpO2) target for extremely preterm infants is unknown.ObjectiveTo systematically review evidence evaluating the effect of restricted vs liberal oxygen exposure on morbidity and mortality in extremely preterm infants.Data sourcesMEDLINE, PubMed, CENTRAL, and CINAHL databases from their inception to March 31, 2014, and abstracts submitted to Pediatric Academic Societies from 2000 to 2014.Study selectionAll published randomized trials evaluating the effect of restricted (SpO2, 85%-89%) vs liberal (SpO2, 91%-95%) oxygen exposure in preterm infants (

Published
2015

42. A Modified Delphi Process to Prioritize Experiences and Guidance Related to ICU Restricted Visitation Policies During the Coronavirus Disease 2019 Pandemic

Author

Fiest, Kirsten M., Krewulak, Karla D., Makuk, Kira, Jaworska, Natalia, Hernández, Laura, Bagshaw, Sean M., Burns, Karen E., Cook, Deborah J., Doig, Christopher J., Fox-Robichaud, Alison, Fowler, Robert A., Kho, Michelle E., Parhar, Ken Kuljit S., Rewa, Oleksa G., Rochwerg, Bram, Sept, Bonnie G., Soo, Andrea, Spence, Sean, West, Andrew, Stelfox, Henry T., and Parsons Leigh, Jeanna

Published
2021
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49. Critical Care Cycling to ImproveLowerExtremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients

Author

Kho, Michelle E, primary, Reid, Julie, additional, Molloy, Alexander J, additional, Herridge, Margaret S, additional, Seely, Andrew J, additional, Rudkowski, Jill C, additional, Buckingham, Lisa, additional, Heels-Ansdell, Diane, additional, Karachi, Tim, additional, Fox-Robichaud, Alison, additional, Ball, Ian M, additional, Burns, Karen E A, additional, Pellizzari, Joseph R, additional, Farley, Christopher, additional, Berney, Sue, additional, Pastva, Amy M, additional, Rochwerg, Bram, additional, D'Aragon, Frédérick, additional, Lamontagne, Francois, additional, Duan, Erick H, additional, Tsang, Jennifer L Y, additional, Archambault, Patrick, additional, English, Shane W, additional, Muscedere, John, additional, Serri, Karim, additional, Tarride, Jean-Eric, additional, Mehta, Sangeeta, additional, Verceles, Avelino C, additional, Reeve, Brenda, additional, O'Grady, Heather, additional, Kelly, Laurel, additional, Strong, Geoff, additional, Hurd, Abby H, additional, Thabane, Lehana, additional, and Cook, Deborah J, additional

Published
2023
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50. What counts as patient-important upper gastrointestinal bleeding in the ICU? A mixed-methods study protocol of patient and family perspectives

Author

Cook, Deborah J, primary, Swinton, Marilyn, additional, Krewulak, Karla D, additional, Fiest, Kirsten, additional, Dionne, Joanna, additional, Debigare, Sylvie, additional, Guyatt, Gordon, additional, Taneja, Shipra, additional, Alhazzani, Waleed, additional, Burns, Karen E A, additional, Marshall, John C, additional, Muscedere, John, additional, Gouskos, Audrey, additional, Finfer, Simon, additional, Deane, Adam M, additional, Myburgh, John, additional, Rochwerg, Bram, additional, Ball, Ian, additional, Mele, Tina, additional, Niven, Daniel, additional, English, Shane, additional, Verhovsek, Madeleine, additional, and Vanstone, Meredith, additional

Published
2023
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